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SF3B6 Gene

protein-coding   GIFtS: 43
GCID: GC02M024291

Splicing Factor 3b, Subunit 6, 14kDa

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Splicing Factor 3b, Subunit 6, 14kDa1 2     Ht0062
Pre MRNA Branch Site Protein P141 2     SAP14a2
SF3b 14 KDa Subunit2 3     SF3B14a2
P142 5     Pre-MRNA Branch Site Protein P142
SAP142 5     Spliceosome-Associated Protein, 14 KDa Subunit2
SF3B142 5     Splicing Factor 3B, 14 KDa Subunit2
HSPC1752     

External Ids:    HGNC: 300961   Entrez Gene: 516392   Ensembl: ENSG000001151287   OMIM: 6078355   UniProtKB: Q9Y3B43   

Export aliases for SF3B6 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SF3B6 Gene:
This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with
both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein
interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly
with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SF3B6 Gene:
SF3B6 (splicing factor 3b, subunit 6, 14kDa) is a protein-coding gene.

UniProtKB/Swiss-Prot: PM14_HUMAN, Q9Y3B4
Function: Necessary for the splicing of pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the
first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of
the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may
facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively

Gene Wiki entry for SF3B6 (SF3B14) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SF3B6
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSF3B6 promoter sequence
   Search Chromatin IP Primers for SF3B6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SF3B6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23

SF3B6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SF3B6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M024291:  view genomic region     (about GC identifiers)

Start:
24,290,454 bp from pter      End:
24,299,314 bp from pter
Size:
8,861 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PM14_HUMAN, Q9Y3B4 (See protein sequence)
Recommended Name: Pre-mRNA branch site protein p14  
Size: 125 amino acids; 14585 Da
Subunit: Component of the splicing factor SF3b complex. Interacts with SF3B1/SF3b155. Component of the U11/U12
snRNPs that are part of the U12-type spliceosome
4 PDB 3D structures from and Proteopedia for SF3B6:
2F9D (3D)        2F9J (3D)        2FHO (3D)        3LQV (3D)    

Explore the universe of human proteins at neXtProt for SF3B6: NX_Q9Y3B4

Explore proteomics data for SF3B6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SF3B6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057131.1  
    ENSEMBL proteins: 
     ENSP00000233468  
    Reactome Protein details: Q9Y3B4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y3B4

    ProtoNet protein and cluster: Q9Y3B4

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: PM14_HUMAN, Q9Y3B4
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with SF3B6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PM14_HUMAN, Q9Y3B4
    Function: Necessary for the splicing of pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the
    first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of
    the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may
    facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SF3B6           About GenesLikeMe


    Phenotypes:
         10 GenomeRNAi human phenotypes for SF3B6:
     Abundance of large cells with   Cell division defect  Decreased cell number, increas  Decreased influenza A H1N1 (A/ 
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 
     Increased number of mitotic ce  Synthetic lethal with Ras 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PM14_HUMAN, Q9Y3B4: Nucleus (Potential)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005689U12-type spliceosomal complex IDA15146077

    Find genes that share ontologies with SF3B6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SF3B6 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome


    Find genes that share SuperPaths with SF3B6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SF3B6
        mRNA Splicing - Major Pathway
    mRNA Splicing - Minor Pathway


    1 Kegg Pathway  (Kegg details for SF3B6):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SF3B6
    Interactions:

        Search GeneGlobe Interaction Network for SF3B6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SF3B6 (Q9Y3B42, 3 ENSP000002334684) via UniProtKB, MINT, STRING, and/or I2D (see all 919)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3B1O755332, 3, ENSP000003353214MINT-7945693 MINT-6488590 MINT-7947479 MINT-8333471 I2D: score=3 STRING: ENSP00000335321
    SF3A2Q154282, 3, ENSP000002214944MINT-5205503 MINT-7947479 I2D: score=2 STRING: ENSP00000221494
    HNRNPFP525972, ENSP000003384774MINT-7945693 MINT-6488590 MINT-7947479 STRING: ENSP00000338477
    HNRNPUQ008392, ENSP000002831794MINT-7945693 MINT-6488590 MINT-7947479 STRING: ENSP00000283179
    SF3B3Q153932, ENSP000003057904MINT-7945693 MINT-6488590 MINT-7947479 STRING: ENSP00000305790
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with SF3B6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SF3B6 (PM14)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SF3B6 gene: 
    NM_016047.3  

    Unigene Cluster for SF3B6:

    Splicing factor 3B, 14 kDa subunit
    Hs.177861  [show with all ESTs]
    Unigene Representative Sequence: BU588343
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233468(uc002rev.3 uc010eyb.3) ENST00000478050
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SF3B6
      QuantiFast Probe-based Assays in human, mouse, rat SF3B6

    Additional mRNA sequence: 

    AF147425.1 AF151868.1 AF161523.1 AF184213.1 AF401310.1 AK000621.1 AK311118.1 AK311908.1 
    BC015463.1 

    9 DOTS entries:

    DT.87016196  DT.102827949  DT.205424  DT.95192179  DT.100036453  DT.100814888  DT.120954565  DT.99986087 
    DT.102827950 

    Selected AceView cDNA sequences (see all 143):

    BU522038 BQ421524 BQ436288 BQ420519 AV728319 CA942421 AI284469 AA314420 
    BQ270108 BU952103 NM_016047 AV726660 BQ286766 BU156831 BQ417065 BQ231342 
    AF184213 BP377558 AF147425 BQ416759 CK822483 CA867128 H47358 BM504699 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SF3B6    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                                            -           -                     
    SP2:                                      -     -           -                     
    SP3:                                -     -     -           -                     
    SP4:                                            -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for SF3B6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SF3B6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SF3B6 Expression
    About this image

    SF3B6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SF3B6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.177861
        Custom PCR Arrays for SF3B6
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SF3B6 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 0610009D07Rik1 , 5 RIKEN cDNA 0610009D07 gene1, 5 92(n)1
    100(a)1
      12 (2.09 cM)5
    660551  NM_025323.21  NP_079599.11 
     48176085 
    chicken
    (Gallus gallus)
    Aves SF3B141 splicing factor 3B, 14 kDa subunit 85.6(n)
    100(a)
      421976  XM_419986.3  XP_419986.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    100(a)
    1 ↔ 1
    1(140199310-140212359)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688422 hypothetical protein MGC68842 80.8(n)    BC057709.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb78f042 Transcribed sequence with strong similarity to protein more 82.29(n)    CB355525.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG132981 CG13298 67.83(n)
    77.39(a)
      38720  NM_139780.3  NP_648037.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C50D2.51 C50D2.5 61.87(n)
    68(a)
      173394  NM_061258.4  NP_493659.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G121901 AT5G12190 57.3(n)
    63.64(a)
      831092  NM_121257.2  NP_196780.1 
    rice
    (Oryza sativa)
    Liliopsida Os.53362 Oryza sativa (japonica cultivar-group) cDNA clone0 more 67.61(n)    AK121661.1 


    ENSEMBL Gene Tree for SF3B6 (if available)
    TreeFam Gene Tree for SF3B6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SF3B6 gene

    Find genes that share paralogs with SF3B6           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SF3B6
    PGOHUM00000237457


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SF3B6 (see all 214)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101883131,2
    C--24289969(+) AAAAAA/CCAATT 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs1407987651,2
    --24290198(+) TTTGGC/TTTCCT 1 -- ds50010--------
    rs763542601,2
    C,F--24290650(+) TCTGTG/ATTGAT 2 /N syn11Minor allele frequency- A:0.00NA 4542
    rs617421491,2
    C,F--24290671(+) TCCTTG/AAGAAG 2 /L syn14Minor allele frequency- A:0.08NS NA EU 6060
    rs1887042801,2
    --24290842(+) CTACAC/TTAATT 1 -- int10--------
    rs116863891,2
    A,H--24290919(+) gctccA/Cccccc 1 -- int10--------
    rs1468741861,2
    --24291046(+) GCCAGA/GATGGT 1 -- int10--------
    rs1811387311,2
    --24291076(+) GATCCA/GCCCAC 1 -- int10--------
    rs101940041,2
    C,F,A--24291080(+) CGCCCG/ACCTCG 1 -- int14Minor allele frequency- A:0.50NA CSA 8
    rs19710741,2
    C,F,A,H--24291124(+) CACCGC/TGCCCG 1 -- int14Minor allele frequency- T:0.42NA WA CSA 12

    HapMap Linkage Disequilibrium report for SF3B6 (24290454 - 24299314 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SF3B6: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SF3B6
    DNA2.0 Custom Variant and Variant Library Synthesis for SF3B6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607835    OMIM disorders: --


    Find genes that share disorders with SF3B6           About GenesLikeMe


    Export disorders for SF3B6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SF3B6 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with SF3B6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel U2 and U11/U12 snRNP protein that associates with the pre- mRNA branch site. (PubMed id 11500380)1, 2, 3, 9 Will C.L.... Query C.C. (EMBO J. 2001)
    2. Molecular architecture of the multiprotein splicing factor SF3b. (PubMed id 12738865)1, 2, 3, 9 Golas M.M.... Stark H. (Science 2003)
    3. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (RNA 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PubMed id 12234937)1, 2 Will C.L.... Luehrmann R. (EMBO J. 2002)
    6. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    8. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    9. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51639 HGNC: 30096 AceView: P14 Ensembl:ENSG00000115128 euGenes: HUgn51639
    ECgene: SF3B6 Kegg: 51639 H-InvDB: SF3B6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SF3B6 gene:
    Search GeneIP for patents involving SF3B6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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