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Aliases for SF3B6 Gene

Aliases for SF3B6 Gene

  • Splicing Factor 3b, Subunit 6, 14kDa 2 3 4
  • SF3B14 3 4 6
  • SAP14 3 4 6
  • Spliceosome-Associated Protein, 14-KDa 3 4
  • Pre MRNA Branch Site Protein P14 2 3
  • Pre-MRNA Branch Site Protein P14 3 4
  • SF3b 14 KDa Subunit 3 4
  • SF3B14a 3 4
  • P14 3 6
  • Spliceosome-Associated Protein, 14 KDa Subunit 3
  • Splicing Factor 3B, 14 KDa Subunit 3
  • Splicing Factor 3B Subunit 6 3
  • CGI-110 3
  • HSPC175 3
  • SAP14a 3
  • Ht006 3

External Ids for SF3B6 Gene

Previous GeneCards Identifiers for SF3B6 Gene

  • GC02M024291

Summaries for SF3B6 Gene

Entrez Gene Summary for SF3B6 Gene

  • This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008]

GeneCards Summary for SF3B6 Gene

SF3B6 (Splicing Factor 3b, Subunit 6, 14kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome.

UniProtKB/Swiss-Prot for SF3B6 Gene

  • Necessary for the splicing of pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively.

Gene Wiki entry for SF3B6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SF3B6 Gene

Genomics for SF3B6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SF3B6 Gene

Start:
24,067,584 bp from pter
End:
24,076,444 bp from pter
Size:
8,861 bases
Orientation:
Minus strand

Genomic View for SF3B6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SF3B6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SF3B6 Gene

No data available for Regulatory Elements for SF3B6 Gene

Proteins for SF3B6 Gene

  • Protein details for SF3B6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3B4-SF3B6_HUMAN
    Recommended name:
    Splicing factor 3B subunit 6
    Protein Accession:
    Q9Y3B4
    Secondary Accessions:
    • Q53TM1

    Protein attributes for SF3B6 Gene

    Size:
    125 amino acids
    Molecular mass:
    14585 Da
    Quaternary structure:
    • Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42/SF3B125. Interacts with SF3B1. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.

    Three dimensional structures from OCA and Proteopedia for SF3B6 Gene

neXtProt entry for SF3B6 Gene

Proteomics data for SF3B6 Gene at MOPED

Post-translational modifications for SF3B6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SF3B6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SF3B6 Gene

Domains for SF3B6 Gene

Protein Domains for SF3B6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3B4

UniProtKB/Swiss-Prot:

SF3B6_HUMAN :
  • Q9Y3B4
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the SF3B6 family.
genes like me logo Genes that share domains with SF3B6: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SF3B6 Gene

Function for SF3B6 Gene

Molecular function for SF3B6 Gene

UniProtKB/Swiss-Prot Function: Necessary for the splicing of pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively.

Gene Ontology (GO) - Molecular Function for SF3B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SF3B6: view
genes like me logo Genes that share phenotypes with SF3B6: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SF3B6 Gene

Localization for SF3B6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SF3B6 Gene

Gene Ontology (GO) - Cellular Components for SF3B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005689 U12-type spliceosomal complex IDA 15146077
genes like me logo Genes that share ontologies with SF3B6: view

No data available for Subcellular locations from COMPARTMENTS for SF3B6 Gene

Pathways for SF3B6 Gene

genes like me logo Genes that share pathways with SF3B6: view

Pathways by source for SF3B6 Gene

Gene Ontology (GO) - Biological Process for SF3B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SF3B6: view

Transcripts for SF3B6 Gene

mRNA/cDNA for SF3B6 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SF3B6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SF3B6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for SF3B6 Gene

GeneLoc Exon Structure for
SF3B6
ECgene alternative splicing isoforms for
SF3B6

Expression for SF3B6 Gene

mRNA expression in normal human tissues for SF3B6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SF3B6 Gene

genes like me logo Genes that share expressions with SF3B6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SF3B6 Gene

Orthologs for SF3B6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3B6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToOne
SF3B14 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia SF3B14 35
  • 97.6 (n)
  • 100 (a)
SF3B14 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 100 (a)
OneToOne
SF3B14 35
  • 97.07 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia 0610009D07Rik 35
  • 92 (n)
  • 100 (a)
0610009D07Rik 16
0610009D07Rik 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100365504 35
  • 91.47 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 100 (a)
OneToOne
SF3B14 35
  • 85.6 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68842 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sf3b14 35
  • 82.13 (n)
  • 99.2 (a)
Str.5936 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10259 35
zebrafish
(Danio rerio)
Actinopterygii sf3b14 36
  • 100 (a)
OneToOne
sf3b6 35
  • 81.87 (n)
  • 100 (a)
wufb78f04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002780 35
  • 66.39 (n)
  • 73.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13298 35
  • 67.83 (n)
  • 77.39 (a)
CG13298 36
  • 74 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C50D2.5 35
  • 61.87 (n)
  • 68 (a)
C50D2.5 36
  • 62 (a)
OneToOne
soybean
(Glycine max)
eudicotyledons Gma.8283 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G12190 35
  • 57.3 (n)
  • 63.64 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3044 35
rice
(Oryza sativa)
Liliopsida Os.5336 35
Os03g0811700 35
  • 61.02 (n)
  • 65.32 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.3276 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5237 35
Species with no ortholog for SF3B6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SF3B6 Gene

ENSEMBL:
Gene Tree for SF3B6 (if available)
TreeFam:
Gene Tree for SF3B6 (if available)

Paralogs for SF3B6 Gene

Pseudogenes.org Pseudogenes for SF3B6 Gene

genes like me logo Genes that share paralogs with SF3B6: view

No data available for Paralogs for SF3B6 Gene

Variants for SF3B6 Gene

Sequence variations from dbSNP and Humsavar for SF3B6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs736843 -- 24,073,472(+) TATGG(G/T)TAATG intron-variant
rs736844 -- 24,073,096(+) TATTT(C/T)CAGCT intron-variant
rs1247709 -- 24,071,270(+) acagg(C/T)gtgag intron-variant
rs1971074 -- 24,068,254(+) CACCG(C/T)GCCCG intron-variant
rs3769665 -- 24,073,736(-) ACACT(A/G)TGTTT intron-variant

Relevant External Links for SF3B6 Gene

HapMap Linkage Disequilibrium report
SF3B6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SF3B6 Gene

Disorders for SF3B6 Gene

No disorders were found for SF3B6 Gene.

No data available for UniProtKB/Swiss-Prot for SF3B6 Gene

Publications for SF3B6 Gene

  1. A novel U2 and U11/U12 snRNP protein that associates with the pre- mRNA branch site. (PMID: 11500380) Will C.L. … Query C.C. (EMBO J. 2001) 2 3 4 23
  2. Molecular architecture of the multiprotein splicing factor SF3b. (PMID: 12738865) Golas M.M. … Stark H. (Science 2003) 2 3 4 23
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4

Products for SF3B6 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SF3B6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SF3B6
    • Block miRNA regulation of SF3B6 using miScript Target Protectors

    Sources for SF3B6 Gene

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