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Aliases for SF3B5 Gene

Aliases for SF3B5 Gene

  • Splicing Factor 3b, Subunit 5, 10kDa 2 3
  • Pre-MRNA-Splicing Factor SF3b 10 KDa Subunit 3 4
  • SF3b10 3 4
  • Splicing Factor 3B Subunit 5 3
  • SF3b5 4
  • Ysf3 3

External Ids for SF3B5 Gene

Previous GeneCards Identifiers for SF3B5 Gene

  • GC06M144351
  • GC06M144396
  • GC06M144457
  • GC06M141979
  • GC06M144416

Summaries for SF3B5 Gene

GeneCards Summary for SF3B5 Gene

SF3B5 (Splicing Factor 3b, Subunit 5, 10kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome.

Gene Wiki entry for SF3B5 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SF3B5 Gene

Genomics for SF3B5 Gene

Regulatory Elements for SF3B5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SF3B5 Gene

144,094,881 bp from pter
144,095,617 bp from pter
737 bases
Minus strand

Genomic View for SF3B5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SF3B5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SF3B5 Gene

Proteins for SF3B5 Gene

  • Protein details for SF3B5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Splicing factor 3B subunit 5
    Protein Accession:
    Secondary Accessions:
    • B2R568
    • Q7RTV1

    Protein attributes for SF3B5 Gene

    86 amino acids
    Molecular mass:
    10135 Da
    Quaternary structure:
    • Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42/SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.

neXtProt entry for SF3B5 Gene

Proteomics data for SF3B5 Gene at MOPED

Post-translational modifications for SF3B5 Gene

  • Ubiquitination at Lys17, Lys28, and Lys71
  • Modification sites at PhosphoSitePlus

Other Protein References for SF3B5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SF3B5 Gene

Domains for SF3B5 Gene

Protein Domains for SF3B5 Gene

Suggested Antigen Peptide Sequences for SF3B5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BWJ5
  • Belongs to the SF3B5 family.
genes like me logo Genes that share domains with SF3B5: view

No data available for Gene Families for SF3B5 Gene

Function for SF3B5 Gene

genes like me logo Genes that share phenotypes with SF3B5: view

Animal Model Products

miRNA for SF3B5 Gene

miRTarBase miRNAs that target SF3B5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SF3B5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SF3B5 Gene

Localization for SF3B5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SF3B5 Gene

Subcellular locations from

Jensen Localization Image for SF3B5 Gene COMPARTMENTS Subcellular localization image for SF3B5 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for SF3B5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005689 U12-type spliceosomal complex IDA 15146077
genes like me logo Genes that share ontologies with SF3B5: view

Pathways for SF3B5 Gene

genes like me logo Genes that share pathways with SF3B5: view

Pathways by source for SF3B5 Gene

1 KEGG pathway for SF3B5 Gene

Gene Ontology (GO) - Biological Process for SF3B5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SF3B5: view

Transcripts for SF3B5 Gene

mRNA/cDNA for SF3B5 Gene

(451) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SF3B5 Gene

Splicing factor 3b, subunit 5, 10kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SF3B5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SF3B5 Gene

No ASD Table

Relevant External Links for SF3B5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SF3B5 Gene

mRNA expression in normal human tissues for SF3B5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SF3B5 Gene

This gene is overexpressed in Fetal testis (6.2) and NK cells (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SF3B5 Gene

SOURCE GeneReport for Unigene cluster for SF3B5 Gene Hs.110695

genes like me logo Genes that share expressions with SF3B5: view

Expression partners for SF3B5 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SF3B5 Gene

Orthologs for SF3B5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3B5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SF3B5 35
  • 92.64 (n)
  • 100 (a)
SF3B5 36
  • 100 (a)
(Canis familiaris)
Mammalia SF3B5 35
  • 96.51 (n)
  • 100 (a)
SF3B5 36
  • 100 (a)
(Mus musculus)
Mammalia Sf3b5 35
  • 90.7 (n)
  • 98.84 (a)
Sf3b5 16
Sf3b5 36
  • 99 (a)
(Pan troglodytes)
Mammalia SF3B5 35
  • 100 (n)
  • 100 (a)
SF3B5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sf3b5 35
  • 88.76 (n)
  • 98.84 (a)
(Monodelphis domestica)
Mammalia SF3B5 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia SF3B5 36
  • 97 (a)
(Gallus gallus)
Aves SF3B5 35
  • 90.7 (n)
  • 97.67 (a)
(Anolis carolinensis)
Reptilia SF3B5 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sf3b5 35
  • 81.78 (n)
  • 95.35 (a)
Str.16 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8383 35
(Danio rerio)
Actinopterygii sf3b5 35
  • 85.1 (n)
  • 95.29 (a)
sf3b5 36
  • 94 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011907 35
  • 72.55 (n)
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11985 35
  • 74.9 (n)
  • 83.53 (a)
CG11985 36
  • 84 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G14342 35
  • 59.13 (n)
  • 63.1 (a)
(Oryza sativa)
Liliopsida Os08g0278966 35
  • 57.54 (n)
  • 60.71 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02000 35
  • 57.32 (n)
  • 57.32 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sab10 35
  • 52.74 (n)
  • 54.43 (a)
Species with no ortholog for SF3B5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SF3B5 Gene

Gene Tree for SF3B5 (if available)
Gene Tree for SF3B5 (if available)

Paralogs for SF3B5 Gene

No data available for Paralogs for SF3B5 Gene

Variants for SF3B5 Gene

Sequence variations from dbSNP and Humsavar for SF3B5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1053634 -- 144,095,311(-) AAGCG(A/C)GAGTC synonymous-codon, reference
rs1054615 -- 144,095,004(-) GTGAG(A/G)TCCTA utr-variant-3-prime
rs1054616 -- 144,094,994(-) TAGAT(C/T)TGGCG utr-variant-3-prime
rs3060743 -- 144,095,912(+) TGTTT(-/GTTT)AAGAC upstream-variant-2KB
rs3835227 -- 144,095,892(-) ACAAC(-/A/ACAA)CAGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SF3B5 Gene

Variant ID Type Subtype PubMed ID
nsv886738 CNV Loss 21882294

Relevant External Links for SF3B5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SF3B5 Gene

Disorders for SF3B5 Gene

No disorders were found for SF3B5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SF3B5 Gene

Publications for SF3B5 Gene

  1. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PMID: 12234937) Will C.L. … Luehrmann R. (EMBO J. 2002) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will C.L. … Luehrmann R. (RNA 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for SF3B5 Gene

Sources for SF3B5 Gene

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