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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SF3B5 Gene

protein-coding GIFtS: 50
GCID: GC06M144416

splicing factor 3b, subunit 5, 10kDa

Explore 1 disease affiliated with
SF3B5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Splicing Factor 3b, Subunit 5, 10kDa¹ ²		MGC3133¹
SF3b10¹ ²		Splicing Factor 3B Subunit 5²
Ysf3¹ ²		SF3B10³
Pre-MRNA-Splicing Factor SF3b 10 KDa Subunit² ³		SF3b5³

External Ids:	HGNC: 21083¹	Entrez Gene: 83443²	Ensembl: ENSG00000169976⁷	UniProtKB: Q9BWJ5³

Export aliases for SF3B5 gene to outside databases

Previous GC identifers: GC06M144351 GC06M144396 GC06M144457 GC06M141979

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for SF3B5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SF3B5 gene promoter:
ER-alpha GCNF XBP-1 LCR-F1 Nkx5-1 HNF-4alpha1 RORalpha2 GCNF-1 GCNF-2 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SF3B5 promoter sequence

Search SABiosciences Chromatin IP Primers for SF3B5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SF3B5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.2 Ensembl cytogenetic band: 6q24.2 HGNC cytogenetic band: 6q24.1

SF3B5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SF3B5 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M144416: view genomic region (about GC identifiers)

Start:	144,416,018 bp from pter	End:	144,416,754 bp from pter
Size:	737 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SF3B5_HUMAN, Q9BWJ5 (See protein sequence)

Recommended Name: Splicing factor 3B subunit 5

Size: 86 amino acids; 10135 Da

Subunit: Component of splicing factor SF3B which is composed of four subunits; SF3B4/SAP49, SF3B3/SAP130, SF3B2/SAP145,

SF3B1/SAP155. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear

ribonucleoproteins complex (U2 snRNP). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome

Subcellular location: Nucleus (By similarity)

Secondary accessions: B2R568 Q7RTV1

Explore the universe of human proteins at neXtProt for SF3B5: NX_Q9BWJ5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BWJ5

SF3B5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_112577.1

ENSEMBL proteins:

ENSP00000356541

Reactome Protein details: Q9BWJ5
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: SF3B5 OriGene Protein Over-expression Lysate: SF3B5 OriGene Custom Protein Services for SF3B5
	GenScript Custom Purified and Recombinant Proteins Services for SF3B5
	Novus Biologicals SF3B5 Protein Novus Biologicals SF3B5 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SF3B5

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005689	U12-type spliceosomal complex	IDA	15146077

SF3B5 for ontologies About GeneDecksing

SF3B5 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for SF3B5
	Novus Biologicals SF3B5 Antibody
	Search for Antibodies for SF3B5 at Abcam
	Uscn Antibodies for SF3B5
	Search ThermoFisher Antibodies for SF3B5

Assay Products for SF3B5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SF3B5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SF3B5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SF3B5 for domains About GeneDecksing

2 InterPro domains/families:

IPR017089 Splicing_factor_3B_subunit_5

IPR009846 SF3b5/RDS3-10

Graphical View of Domain Structure for InterPro Entry Q9BWJ5

ProtoNet protein and cluster: Q9BWJ5

1 Blocks protein family: IPB009846 Splicing factor 3B subunit 10

UniProtKB/Swiss-Prot: SF3B5_HUMAN, Q9BWJ5

Similarity: Belongs to the SF3B5 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		OriGene 3'-UTR Clone: SF3B5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SF3B5
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SF3B5
		SwitchGear 3'UTR luciferase reporter plasmid: SF3B5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SF3B5 (see all 7) OriGene shRNA RFP: SF3B5 OriGene siRNA: SF3B5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SF3B5

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SF3B5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B5 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SF3B5 (NM_031287)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SF3B5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SF3B5
		Search LifeMap BioReagents cell lines for SF3B5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3B5

3 GenomeRNAi human phenotypes for SF3B5:

Decreased viability

Increased gamma-H2AX phosphory

Increased number of cells in m

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing	1.00	mRNA processing	0.48
mRNA Splicing - Major Pathway	1.00	mRNA Splicing - Minor Pathway	0.40
Processing of Capped Intron-Containing Pre-mRNA	0.96	Spliceosome	0.31
mRNA Processing	0.82

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for SF3B5

mRNA processing

5/6 Reactome Pathways for SF3B5 (see all 6)

	mRNA Splicing - Major Pathway
	mRNA Splicing
	Gene Expression
	mRNA Processing
	mRNA Splicing - Minor Pathway

1 Kegg Pathway (Kegg details for SF3B5):

Spliceosome

SF3B5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SF3B5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/98 Interacting proteins for SF3B5 (Q9BWJ5^{2, 3} ENSP00000356541⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 98)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SF3A2	Q15428²^,³, ENSP00000221494⁴	MINT-5205521 I2D: score=2 STRING: ENSP00000221494
SF3B1	O75533³, ENSP00000335321⁴	I2D: score=1 STRING: ENSP00000335321
SRRM2	Q9UQ35³, ENSP00000301740⁴	I2D: score=1 STRING: ENSP00000301740
ALYREF	ENSP00000331817⁴	STRING: ENSP00000331817
CD2BP2	ENSP00000304903⁴	STRING: ENSP00000304903

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0008380	RNA splicing	TAS	--
GO:0010467	gene expression	TAS	--

SF3B5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SF3B5
Search CenterWatch for drugs/clinical trials and news about SF3B5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SF3B5 gene:

NM_031287.2

Unigene Cluster for SF3B5:

Splicing factor 3b, subunit 5, 10kDa

Hs.110695 [show with all ESTs]

Unigene Representative Sequence: BM467616

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000367569(uc003qkr.1)

miRNA Products:		OriGene 3'-UTR Clone: SF3B5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SF3B5
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SF3B5
		SwitchGear 3'UTR luciferase reporter plasmid: SF3B5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SF3B5 (see all 7) OriGene shRNA RFP: SF3B5 OriGene siRNA: SF3B5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SF3B5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B5 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SF3B5 (NM_031287)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SF3B5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SF3B5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SF3B5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SF3B5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SF3B5

Additional cDNA sequence:

AK074417.1 AK312079.1 BC000198.1

12 DOTS entries:

DT.120071 DT.92441334 DT.95242159 DT.121304831 DT.100826587 DT.92441330 DT.92441336 DT.100826586

DT.121304814 DT.121304819 DT.40121587 DT.100826585

24/451 AceView cDNA sequences (see all 451):

BI828680 BM692220 CD366304 AA938651 CB123296 CA411860 BM793979 AA338460

BM795220 CA414933 AI373551 CB124150 AI193539 BM887805 CD674339 BU069253

AI581557 W74221 BU579941 AA888967 BU786521 H04290 CA841729 AA341370

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SF3B5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGCTGGAGT

About this image

SF3B5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)

Bone, Cartilage, Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SF3B5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SF3B5

SOURCE GeneReport for Unigene cluster: Hs.110695

SABiosciences Custom PCR Arrays for SF3B5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SF3B5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SF3B5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SF3B5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SF3B5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3B5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3B5 gene from 8/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sf3b5^{1 , 5}	splicing factor 3b, subunit 5^{1, 5}	90.7(n)¹ 98.84(a)¹		10 (4.72 cM)⁵ 66125¹ NM_175102.4¹ NP_780311.2¹ 13005343⁵
chicken (Gallus gallus)	Aves	SF3B5¹	splicing factor 3b, subunit 5, 10kDa	90.7(n) 97.67(a)		769794 XM_001232552.2 XP_001232553.1
lizard (Anolis carolinensis)	Reptilia	SF3B5⁶	--	97(a)	1 ↔ 1	1(206065912-206066169)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8383²	Xenopus laevis transcribed sequence with strong similarity more	84.38(n)		BJ614545.1
zebrafish (Danio rerio)	Actinopterygii	BM534535.1²	--	85.38(n)		BM534535.1
fruit fly (Drosophila melanogaster)	Insecta	CG11985¹	CG11985	74.9(n) 83.53(a)		50007 NM_143932.2 NP_652189.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G14342¹	splicing factor 3B subunit 5	59.13(n) 63.1(a)		827077 NM_179048.2 NP_849379.1
rice (Oryza sativa)	Liliopsida	Os08g0278966¹	hypothetical protein	57.54(n) 60.71(a)		9272211 NM_001188564.1 NP_001175493.1

ENSEMBL Gene Tree for SF3B5 (if available)
TreeFam Gene Tree for SF3B5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17073339^1,2	C,F,H,	--	144415689(+)	`TTCTGG/TAGACA`	1	--	int¹		21		NA EA NS WA	2554
rs143226044^1,2		--	144415713(+)	`CCAAG-/AAAAAA`	1	--	int¹		0	--	--	--	--
rs77373980^1,2	C,F,	--	144415821(+)	`CAAATT/CTCAAT`	1	--	int¹		1		WA	118
rs202064464^1,2	C	--	144415882(-)	`TTAATC/TCCCCG`	1	--	int¹		0	--	--	--	--
rs191348516^1,2		--	144415941(+)	`CATGCC/GCTCCC`	1	--	int¹		0	--	--	--	--
rs147119083^1,2	C,	--	144416042(+)	`TTTAT-/GGAAAA`	1	--	ut3¹		0	--	--	--	--
rs116855210^1,2	F,	--	144416101(+)	`ACTCCA/CGCGCC`	1	--	ut3¹		1		EA	120
rs144500769^1,2		--	144416160(+)	`CAGTTC/TTCAGG`	1	--	ut3¹		0	--	--	--	--
rs115440792^1,2	F,	--	144416275(+)	`AGCCAT/AGGAGA`	1	--	ut3¹		1		WA	118
rs183215566^1,2		--	144416308(+)	`TACTTA/CAGAGG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SF3B5 (144416018 - 144416754 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SF3B5: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SF3B5

DNA2.0 Custom Variant and Variant Library Synthesis for SF3B5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SF3B5 for disorders About GeneDecksing

1 disease for SF3B5: About MalaCards

malaria

Export disorders for SF3B5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SF3B5 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with SF3B5)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PubMed id 12234937)^{1, 2, 3} Will C.L....Luhrmann R. (2002)
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)^{1, 2} Will C.L.... Luehrmann R. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)¹ Emanuele M.J....Elledge S.J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83443	HGNC: 21083	AceView: SF3B5	Ensembl:ENSG00000169976	euGenes: HUgn83443
ECgene: SF3B5	Kegg: 83443	H-InvDB: SF3B5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SF3B5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SF3B5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SF3B5 gene:
Search GeneIP for patents involving SF3B5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SF3B5
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SF3B5 gene at Home site.

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SF3B5 Gene

splicing factor 3b, subunit 5, 10kDa

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SF3B5 Gene

splicing factor 3b, subunit 5, 10kDa

Aliasesfor SF3B5 gene

Summariesfor SF3B5 gene

Genomic Viewsfor SF3B5 gene

Proteinsfor SF3B5 gene

Protein Domains /Familiesfor SF3B5 gene

Functionfor SF3B5 gene

Pathways & Interactionsfor SF3B5 gene

Drugs & Compoundsfor SF3B5 gene

Transcriptsfor SF3B5 gene

Expression for SF3B5 gene

Orthologsfor SF3B5 gene

Paralogsfor SF3B5 gene

Genomic Variantsfor SF3B5 gene

Disorders / Diseasesfor SF3B5 gene

Publicationsfor SF3B5 gene

External Searches for SF3B5 gene

Genome Databases showing SF3B5 gene

Other Databases showing SF3B5 gene

Specialized Databases showing SF3B5 gene

Intellectual Propertyfor SF3B5 gene

Productsfor SF3B5 gene

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Aliases
for SF3B5 gene

Summaries
for SF3B5 gene

Genomic Views
for SF3B5 gene

Proteins
for SF3B5 gene

Protein Domains /
Families
for SF3B5 gene

Function
for SF3B5 gene

Pathways & Interactions
for SF3B5 gene

Drugs & Compounds
for SF3B5 gene

Transcripts
for SF3B5 gene

Expression
for SF3B5 gene

Orthologs
for SF3B5 gene

Paralogs
for SF3B5 gene

Genomic Variants
for SF3B5 gene

Disorders / Diseases
for SF3B5 gene

Publications
for SF3B5 gene

Intellectual Property
for SF3B5 gene

Products
for SF3B5 gene