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Aliases for SF3B5 Gene

Aliases for SF3B5 Gene

  • Splicing Factor 3b Subunit 5 2 3 5
  • Pre-MRNA-Splicing Factor SF3b 10 KDa Subunit 3 4
  • Splicing Factor 3b, Subunit 5, 10kDa 2 3
  • SF3b10 3 4
  • SF3b5 4
  • Ysf3 3

External Ids for SF3B5 Gene

Previous GeneCards Identifiers for SF3B5 Gene

  • GC06M144351
  • GC06M144396
  • GC06M144457
  • GC06M141979
  • GC06M144416

Summaries for SF3B5 Gene

GeneCards Summary for SF3B5 Gene

SF3B5 (Splicing Factor 3b Subunit 5) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression.

Gene Wiki entry for SF3B5 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SF3B5 Gene

Genomics for SF3B5 Gene

Regulatory Elements for SF3B5 Gene

Enhancers for SF3B5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SF3B5 on UCSC Golden Path with GeneCards custom track

Promoters for SF3B5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SF3B5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SF3B5 Gene

144,094,881 bp from pter
144,095,617 bp from pter
737 bases
Minus strand

Genomic View for SF3B5 Gene

Genes around SF3B5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SF3B5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SF3B5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SF3B5 Gene

Proteins for SF3B5 Gene

  • Protein details for SF3B5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Splicing factor 3B subunit 5
    Protein Accession:
    Secondary Accessions:
    • B2R568
    • Q7RTV1

    Protein attributes for SF3B5 Gene

    86 amino acids
    Molecular mass:
    10135 Da
    Quaternary structure:
    • Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42/SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.

neXtProt entry for SF3B5 Gene

Proteomics data for SF3B5 Gene at MOPED

Post-translational modifications for SF3B5 Gene

  • Ubiquitination at Lys 17, Lys 28, and Lys 71
  • Modification sites at PhosphoSitePlus

Other Protein References for SF3B5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SF3B5 Gene

Domains & Families for SF3B5 Gene

Protein Domains for SF3B5 Gene

Suggested Antigen Peptide Sequences for SF3B5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SF3B5 family.
  • Belongs to the SF3B5 family.
genes like me logo Genes that share domains with SF3B5: view

No data available for Gene Families for SF3B5 Gene

Function for SF3B5 Gene

genes like me logo Genes that share phenotypes with SF3B5: view

Animal Model Products

miRNA for SF3B5 Gene

miRTarBase miRNAs that target SF3B5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SF3B5 Gene

Localization for SF3B5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SF3B5 Gene

Subcellular locations from

Jensen Localization Image for SF3B5 Gene COMPARTMENTS Subcellular localization image for SF3B5 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for SF3B5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005686 U2 snRNP IBA --
GO:0005689 U12-type spliceosomal complex IDA 15146077
genes like me logo Genes that share ontologies with SF3B5: view

Pathways & Interactions for SF3B5 Gene

genes like me logo Genes that share pathways with SF3B5: view

Pathways by source for SF3B5 Gene

1 KEGG pathway for SF3B5 Gene

Gene Ontology (GO) - Biological Process for SF3B5 Gene


No data available for SIGNOR curated interactions for SF3B5 Gene

Drugs & Compounds for SF3B5 Gene

No Compound Related Data Available

Transcripts for SF3B5 Gene

mRNA/cDNA for SF3B5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(451) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SF3B5 Gene

Splicing factor 3b, subunit 5, 10kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SF3B5 Gene

No ASD Table

Relevant External Links for SF3B5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SF3B5 Gene

mRNA expression in normal human tissues for SF3B5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SF3B5 Gene

This gene is overexpressed in Fetal testis (6.2) and NK cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SF3B5 Gene

SOURCE GeneReport for Unigene cluster for SF3B5 Gene Hs.110695

genes like me logo Genes that share expression patterns with SF3B5: view

Protein tissue co-expression partners for SF3B5 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SF3B5 Gene

Orthologs for SF3B5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3B5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SF3B5 35
  • 92.64 (n)
  • 100 (a)
SF3B5 36
  • 100 (a)
(Canis familiaris)
Mammalia SF3B5 35
  • 96.51 (n)
  • 100 (a)
SF3B5 36
  • 100 (a)
(Mus musculus)
Mammalia Sf3b5 35
  • 90.7 (n)
  • 98.84 (a)
Sf3b5 16
Sf3b5 36
  • 99 (a)
(Pan troglodytes)
Mammalia SF3B5 35
  • 100 (n)
  • 100 (a)
SF3B5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sf3b5 35
  • 88.76 (n)
  • 98.84 (a)
(Monodelphis domestica)
Mammalia SF3B5 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia SF3B5 36
  • 97 (a)
(Gallus gallus)
Aves SF3B5 35
  • 90.7 (n)
  • 97.67 (a)
(Anolis carolinensis)
Reptilia SF3B5 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sf3b5 35
  • 81.78 (n)
  • 95.35 (a)
Str.16 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8383 35
(Danio rerio)
Actinopterygii sf3b5 35
  • 85.1 (n)
  • 95.29 (a)
sf3b5 36
  • 94 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011907 35
  • 72.55 (n)
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11985 35
  • 74.9 (n)
  • 83.53 (a)
CG11985 36
  • 84 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G14342 35
  • 59.13 (n)
  • 63.1 (a)
(Oryza sativa)
Liliopsida Os08g0278966 35
  • 57.54 (n)
  • 60.71 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02000 35
  • 57.32 (n)
  • 57.32 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sab10 35
  • 52.74 (n)
  • 54.43 (a)
Species with no ortholog for SF3B5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SF3B5 Gene

Gene Tree for SF3B5 (if available)
Gene Tree for SF3B5 (if available)

Paralogs for SF3B5 Gene

No data available for Paralogs for SF3B5 Gene

Variants for SF3B5 Gene

Sequence variations from dbSNP and Humsavar for SF3B5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1053634 -- 144,095,311(+) AAGCG(A/C/G/T)GAGTC reference, synonymous-codon
rs1054615 -- 144,095,004(-) GTGAG(A/G)TCCTA utr-variant-3-prime
rs1054616 -- 144,094,995(-) TAGAG(C/T)CGGCG utr-variant-3-prime
rs9496860 -- 144,097,570(+) ctata(C/T)agtat upstream-variant-2KB
rs9689736 -- 144,097,174(+) TTTTT(A/T)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SF3B5 Gene

Variant ID Type Subtype PubMed ID
nsv886738 CNV Loss 21882294

Variation tolerance for SF3B5 Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SF3B5 Gene

Disorders for SF3B5 Gene

Relevant External Links for SF3B5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SF3B5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SF3B5 Gene

Publications for SF3B5 Gene

  1. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PMID: 12234937) Will C.L. … Luehrmann R. (EMBO J. 2002) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. (PMID: 26527279) Campos E.I. … Reinberg D. (Mol. Cell 2015) 3

Products for SF3B5 Gene

Sources for SF3B5 Gene