SF3B4 Gene
protein-coding GIFtS: 60
GCID: GC01M149895
|
|
splicing factor 3b, subunit 4, 49kDa(Previous names: splicing factor 3b, subunit 4, 49kD )
| |
Aliases
for SF3B4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Splicing Factor 3b, Subunit 4, 49kDa1 2 | | SAP 492 3 | | SAP491 2 3 5 | | Splicing Factor 3b, Subunit 4, 49kD1 | | Hsh491 2 | | AFD12 | | SF3b491 2 | | Spliceosomal Protein2 | | Pre-MRNA-Splicing Factor SF3b 49 KDa Subunit2 3 | | Spliceosome-Associated Protein (U2 SnRNP)2 | | Spliceosome-Associated Protein 492 3 | | Splicing Factor 3B Subunit 42 | | SF3b502 3 | | SF3B495 |
Export aliases for SF3B4 gene to outside databasesPrevious GC identifers: GC01M147536 GC01M145637 GC01M146670 GC01M147111 GC01M146708 GC01M148161 GC01M121275 |
Summaries
for SF3B4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SF3B4:
This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to aregion in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A.It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity,this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This proteincontains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly topre-mRNA. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SF3B4_HUMAN, Q15427Function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of thebranch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E'complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome,which is involved in the splicing of rare class of nuclear pre-mRNA intron
Gene Wiki entry for SF3B4
|
Genomic Views
for SF3B4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SF3B4 gene promoter:
AP-1 SREBP-1c IRF-1 LCR-F1 C/EBPalpha SREBP-1b MEF-2A SREBP-1a aMEF-2 ZIC2/Zic2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SF3B4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SF3B4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.2 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21.2SF3B4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M149895: view genomic region
(about GC identifiers)
Start:
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149,895,209 bp from pter |
End:
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149,900,236 bp from pter |
Size:
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5,028 bases |
Orientation:
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minus strand |
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Proteins
for SF3B4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SF3B4_HUMAN, Q15427 (See
protein sequence)Recommended Name: Splicing factor 3B subunit 4 Size: 424 amino acids; 44386 Da
Subunit: Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155,SF3B2/SAP145/SF3B145, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125. SF3Bassociates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex(U2 snRNP). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. SF3B4 interacts directly withSF3B2
Subcellular location: Nucleus (By similarity)
2 PDB 3D structures from  and Proteopedia  for SF3B4:1X5T (3D)
1X5U (3D)
Secondary accessions: Q5SZ63Explore the universe of human proteins at neXtProt for SF3B4: NX_Q15427
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15427
SF3B4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005841.1
ENSEMBL proteins: ENSP00000271628 ENSP00000391114 Reactome Protein details: Q15427
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SF3B4 for ontologies About GeneDecksing
SF3B4 Antibody Products:
Assay Products for SF3B4: |
Protein
Domains /
Families
for SF3B4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SF3B4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15427ProtoNet protein and cluster: Q15427 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: SF3B4_HUMAN, Q15427Similarity: Belongs to the SF3B4 familySimilarity: Contains 2 RRM (RNA recognition motif) domains |
Function
for SF3B4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SF3B4_HUMAN, Q15427Function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of thebranch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E'complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome,which is involved in the splicing of rare class of nuclear pre-mRNA intron
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SF3B4 (NM_005850) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SF3B4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3B4 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SF3B4 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for SF3B4:
|
Pathways & Interactions
for SF3B4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | | | 2 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for SF3B4
5/6 
Reactome Pathways for SF3B4 (see all 6)
1 
Kegg Pathway (Kegg details for SF3B4):
SF3B4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SF3B4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/652 Interacting proteins for SF3B4 (Q154271, 2, 3 ENSP000002716284) via UniProtKB, MINT, STRING, and/or I2D (see all 652)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SF3B2 | Q134352, 3, ENSP000003188614 | MINT-7945693 MINT-8332328 MINT-8333515 I2D:
score=5 STRING: ENSP00000318861 | | STK19 | P498422, 3, ENSP000003644824 | MINT-62583 MINT-62681 MINT-62757 I2D:
score=4 STRING: ENSP00000364482 | | ABL1 | P005192, 3, ENSP000003614234 | MINT-8110743 I2D:
score=3 STRING: ENSP00000361423 | | GRB2 | P629931, 3, ENSP000003390074 | EBI-1047735,EBI-401755 I2D:
score=3 STRING: ENSP00000339007 | | SF3A2 | Q154282, 3, ENSP000002214944 | MINT-5205494 I2D:
score=2 STRING: ENSP00000221494 |
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
SF3B4 for ontologies About GeneDecksing
|
Drugs & Compounds
for SF3B4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SF3B4
Search CenterWatch for drugs/clinical trials and news about SF3B4
|
Transcripts
for SF3B4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SF3B4 gene: NM_005850.4 Unigene Cluster for SF3B4: Splicing factor 3b, subunit 4, 49kDa Hs.516160 [show with all ESTs]Unigene Representative Sequence: BC0908832 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000271628(uc009wll.1 uc001etk.2) ENST00000457312
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SF3B4 (NM_005850) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SF3B4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B4 |
Additional cDNA sequence: AK097315.1 AK223322.1 AK310495.1 BC004273.1 BC013886.2 BC090883.1 19 DOTS entries: DT.416381 DT.100674146 DT.100768025 DT.100674150 DT.121325704 DT.95170197 DT.100039443 DT.100674149 DT.100690113 DT.100772506 DT.100674151 DT.100674157 DT.100841135 DT.100846847 DT.121325760 DT.40233860 DT.95170195 DT.95170200 DT.120773233 24/539 AceView cDNA sequences (see all 539): CB130736 BE277459 BI861193 BM926980 BQ446006 BG024581 CR600971 CD358060 BU502757 CB154904 BQ218795 BI906225 BM464417 BC004273 BQ229586 AA380420 AA494427 BM762457 BM564412 BE890020 BX428757 BQ940959 BU160691 BM801183
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SF3B4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SF3B4
|
Expression
for SF3B4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SF3B4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATACACTGG
About this image
See SF3B4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SF3B4
SOURCE GeneReport for Unigene cluster: Hs.516160
SABiosciences Custom PCR Arrays for SF3B4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SF3B4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SF3B4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SF3B4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SF3B4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3B4 |
Orthologs
for SF3B4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SF3B4 gene from 9/35 species (see all 35) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SF3B41 |
splicing factor 3b, subunit 4, 49kDa |
77.7(n)
91.37(a) |
|
426042 XM_423721.3 XP_423721.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SF3B46 |
-- |
92(a) |
1 ↔ 1 |
GL344255.1(8955-25225) |
African clawed frog
(Xenopus laevis) |
Amphibia |
spx-prov2 |
splicing factor 3b, subunit 4, 49kD |
76.5(n) |
|
BC045264.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
sf3b42 |
splicing factor 3b, subunit 4 |
77.32(n) |
|
192318 BC056532.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Spx1 , 3 |
mRNA splicing RNA binding3
Spliceosomal protein on the X1 |
81(a)3
63.27(n)1
72.01(a)1 |
|
1 5E33
315581 NM_078503.41 NP_511058.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
sap-493 |
Poly(A) RNA binding protein |
73(a) |
|
II(8034428-8035787) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
HSH49(YOR319W)4
HSH491 |
U2-snRNP associated splicing factor with similarity more4
Hsh49p1 |
50.65(n)1
41.34(a)1 |
|
15(912822-913463)4
8544971, 4 NP_014964.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
emb24441 |
splicing factor 3B subunit 4 |
62.2(n)
64.58(a) |
|
816366 NM_127407.3 NP_179441.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.58662 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
74.33(n) |
|
AK060554.1 |
ENSEMBL Gene Tree for SF3B4 (if available)
TreeFam Gene Tree for SF3B4 (if available) |
Paralogs
for SF3B4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SF3B4 gene
- CPSF72 CPSF62 MAPK1IP1L2
12 SIMAP similar genes for SF3B4 using alignment to 2 protein entries: SF3B4_HUMAN (see all proteins):PABPC4L ELAVL1 TIA1 PABPC4 ELAVL2 HNRNPA1
PABPC1L2A PABPC1L2B PABPC3 PABPC1L PABPC1 SRSF5
SF3B4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SF3B4
PGOHUM00000257967
|
Genomic Variants
for SF3B4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SF3B4 (149895209 - 149900236 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SF3B4
2 CNVs: 3313 2326
Human Gene Mutation Database (HGMD): SF3B4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SF3B4 |
|
Disorders
/ Diseases
for SF3B4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SF3B4 for disorders About GeneDecksing
OMIM gene information: 605593
OMIM disorders: --
UniProtKB/Swiss-Prot: SF3B4_HUMAN, Q15427
Defects in SF3B4 are the cause of acrofacial dysostosis type 1 (AFD1) [MIM:154400]. AFD1 is a form ofacrofacial dysostosis, a group of disorders which are characterized by malformation of the craniofacial skeleton andthe limbs. The major facial features of AFD1 include downslanted palpebral fissures, midface retrusion, andmicrognathia, the latter of which often requires the placement of a tracheostomy in early childhood. Limb defectstypically involve the anterior (radial) elements of the upper limbs and manifest as small or absent thumbs,triphalangeal thumbs, radial hyoplasia or aplasia, and radioulnar synostosis. Phocomelia of the upper limbs and,occasionally, lower-limb defects have also been reported
7  diseases for SF3B4: About MalaCardsfanconi's anemia anemia pharyngitis immunodeficiency
malaria pancreatic cancer pancreatitis
Export disorders for SF3B4 gene to outside databases
|
Publications
for SF3B4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SF3B4 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with SF3B4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. (PubMed id 7958871)1, 2, 3, 9 Champion-Arnaud P. and Reed R. (1994)
- Haploinsufficiency of SF3B4, a component of the pre-mR NA spliceosomal complex, causes Nager syndrome. (PubMed id 22541558)1, 2 Bernier F.P....Parboosingh J.S. (2012)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular architecture of the multiprotein splicing factor SF3b. (PubMed id 12738865)1, 2 Golas M.M....Stark H. (2003)
- Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PubMed id 12234937)1, 2 Will C.L....Luhrmann R. (2002)
- Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. (PubMed id 10882114)1, 2 Das R.... Reed R. (2000)
- Splicing factor 3b subunit 4 binds BMPR-IA and inhibits osteochondral cell differentiation. (PubMed id 17513295)1, 9 Watanabe H....Watanabe H. (2007)
- Human immunodeficiency virus type 1 Vpr induces G2 checkpoint activation by interacting with the splicing factor SAP145. (PubMed id 16923959)1, 9 Terada Y. and Yasuda Y. (2006)
|
External Searches for SF3B4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SF3B4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SF3B4 gene
(According to HUGE)
About This Section
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Specialized Databases showing SF3B4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SF3B4 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SF3B4 gene:
Search GeneIP for patents involving SF3B4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SF3B4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for SF3B4 | | OriGene shRNA RFP for SF3B4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SF3B4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SF3B4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SF3B4 | | OriGene 3'-UTR Clone for SF3B4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SF3B4 | | OriGene Custom Protein Services for SF3B4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SF3B4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SF3B4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SF3B4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SF3B4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SF3B4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SF3B4 |
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| | | | Search Tocris compounds for SF3B4 |
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 | | | SF3B4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3B4 |
|  |  |  | | | | ThermoFisher Antibodies for SF3B4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B4 |
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