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Aliases for SF3B3 Gene

Aliases for SF3B3 Gene

  • Splicing Factor 3b, Subunit 3, 130kDa 2 3
  • SF3b130 3 4 6
  • SAP130 3 4 6
  • Pre-MRNA-Splicing Factor SF3b 130 KDa Subunit 3 4
  • Splicing Factor 3b, Subunit 3, 130kD 2 3
  • Spliceosome-Associated Protein 130 3 4
  • SAP 130 3 4
  • STAF130 3 4
  • Pre-MRNA Splicing Factor SF3b, 130 KDa Subunit 3
  • Splicing Factor 3B Subunit 3 3
  • KIAA0017 4
  • RSE1 3

External Ids for SF3B3 Gene

Previous GeneCards Identifiers for SF3B3 Gene

  • GC16P061259
  • GC16P070978
  • GC16P070293
  • GC16P070333
  • GC16P069115
  • GC16P070557
  • GC16P056388

Summaries for SF3B3 Gene

Entrez Gene Summary for SF3B3 Gene

  • This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]

GeneCards Summary for SF3B3 Gene

SF3B3 (Splicing Factor 3b, Subunit 3, 130kDa) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is DDB1.

UniProtKB/Swiss-Prot for SF3B3 Gene

  • Subunit of the splicing factor SF3B required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron

Gene Wiki entry for SF3B3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SF3B3 Gene

Genomics for SF3B3 Gene

Regulatory Elements for SF3B3 Gene

Genomic Location for SF3B3 Gene

Start:
70,523,788 bp from pter
End:
70,577,670 bp from pter
Size:
53,883 bases
Orientation:
Plus strand

Genomic View for SF3B3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SF3B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SF3B3 Gene

Proteins for SF3B3 Gene

  • Protein details for SF3B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15393-SF3B3_HUMAN
    Recommended name:
    Splicing factor 3B subunit 3
    Protein Accession:
    Q15393
    Secondary Accessions:
    • Q6NTI8
    • Q96GC0
    • Q9BPY2
    • Q9UFX7
    • Q9UJ29

    Protein attributes for SF3B3 Gene

    Size:
    1217 amino acids
    Molecular mass:
    135577 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42/SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interaction between SF3B3 and SF3B1 is tighter than the interaction between SF3B3 and SF3B2. Associates with the STAGA transcription coactivator-HAT complex. Interacts with SUPT3H.
    SequenceCaution:
    • Sequence=BAA02805.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA32662.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SF3B3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SF3B3 Gene

Proteomics data for SF3B3 Gene at MOPED

Post-translational modifications for SF3B3 Gene

  • Ubiquitination at Lys109, Lys139, Lys546, Lys812, Lys936, Lys965, Lys1049, Lys1074, and Lys1171
  • Modification sites at PhosphoSitePlus

Other Protein References for SF3B3 Gene

Antibody Products

No data available for DME Specific Peptides for SF3B3 Gene

Domains for SF3B3 Gene

Protein Domains for SF3B3 Gene

Suggested Antigen Peptide Sequences for SF3B3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15393

UniProtKB/Swiss-Prot:

SF3B3_HUMAN :
  • Q15393
Family:
  • Belongs to the RSE1 family.
genes like me logo Genes that share domains with SF3B3: view

No data available for Gene Families for SF3B3 Gene

Function for SF3B3 Gene

Molecular function for SF3B3 Gene

UniProtKB/Swiss-Prot Function:
Subunit of the splicing factor SF3B required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron

Gene Ontology (GO) - Molecular Function for SF3B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IBA --
GO:0005515 protein binding IPI 25036637
genes like me logo Genes that share ontologies with SF3B3: view
genes like me logo Genes that share phenotypes with SF3B3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SF3B3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SF3B3 Gene

Localization for SF3B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SF3B3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SF3B3 Gene COMPARTMENTS Subcellular localization image for SF3B3 gene
Compartment Confidence
nucleus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SF3B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex TAS 10490618
GO:0005689 U12-type spliceosomal complex IDA 15146077
GO:0030532 small nuclear ribonucleoprotein complex TAS 10490618
genes like me logo Genes that share ontologies with SF3B3: view

Pathways for SF3B3 Gene

genes like me logo Genes that share pathways with SF3B3: view

Pathways by source for SF3B3 Gene

Gene Ontology (GO) - Biological Process for SF3B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions TAS 10490618
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing TAS 10490618
GO:0006461 protein complex assembly TAS 10490618
GO:0008380 RNA splicing TAS --
genes like me logo Genes that share ontologies with SF3B3: view

Transcripts for SF3B3 Gene

Unigene Clusters for SF3B3 Gene

Splicing factor 3b, subunit 3, 130kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SF3B3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SF3B3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a ·
SP1: - - -
SP2: -
SP3:
SP4: - - -
SP5: - -
SP6: - -
SP7: - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SF3B3 Gene

GeneLoc Exon Structure for
SF3B3
ECgene alternative splicing isoforms for
SF3B3

Expression for SF3B3 Gene

mRNA expression in normal human tissues for SF3B3 Gene

Protein differential expression in normal tissues for SF3B3 Gene

This gene is overexpressed in Lymph node (7.7) and Tlymphocyte (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SF3B3 Gene

SOURCE GeneReport for Unigene cluster for SF3B3 Gene Hs.514435

genes like me logo Genes that share expressions with SF3B3: view

Expression partners for SF3B3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SF3B3 Gene

Orthologs for SF3B3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3B3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SF3B3 35
  • 92.14 (n)
  • 100 (a)
SF3B3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SF3B3 35
  • 92.08 (n)
  • 99.92 (a)
SF3B3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sf3b3 35
  • 90.77 (n)
  • 99.92 (a)
Sf3b3 16
Sf3b3 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SF3B3 35
  • 99.67 (n)
  • 100 (a)
SF3B3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sf3b3 35
  • 90.91 (n)
  • 99.92 (a)
oppossum
(Monodelphis domestica)
Mammalia SF3B3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SF3B3 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SF3B3 35
  • 82.74 (n)
  • 99.18 (a)
SF3B3 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SF3B3 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sf3b3 35
  • 79.29 (n)
  • 96.71 (a)
Str.11469 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7617 35
zebrafish
(Danio rerio)
Actinopterygii LOC100334114 35
  • 78.61 (n)
  • 93.43 (a)
wufb81f05 35
sf3b3 36
  • 93 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2859 35
fruit fly
(Drosophila melanogaster)
Insecta CG13900 37
  • 75 (a)
CG13900 35
  • 66.56 (n)
  • 75.76 (a)
CG13900 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005549 35
  • 67.38 (n)
  • 78.21 (a)
worm
(Caenorhabditis elegans)
Secernentea K02F2.3 37
  • 60 (a)
teg-4 35
  • 59.46 (n)
  • 61.67 (a)
teg-4 36
  • 60 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSE1 36
  • 20 (a)
OneToMany
RSE1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G55200 35
  • 59.86 (n)
  • 59.13 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3072 35
rice
(Oryza sativa)
Liliopsida Os.17819 35
Os02g0137400 35
  • 57.68 (n)
  • 56.35 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5102 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00396 35
  • 53.8 (n)
  • 51.37 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp12 35
  • 50.7 (n)
  • 47.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.949 36
  • 73 (a)
OneToOne
Species with no ortholog for SF3B3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SF3B3 Gene

ENSEMBL:
Gene Tree for SF3B3 (if available)
TreeFam:
Gene Tree for SF3B3 (if available)

Paralogs for SF3B3 Gene

Paralogs for SF3B3 Gene

genes like me logo Genes that share paralogs with SF3B3: view

Variants for SF3B3 Gene

Sequence variations from dbSNP and Humsavar for SF3B3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs12909 -- 70,568,318(+) ACTAT(C/T)GGACA reference, synonymous-codon
rs1138424 -- 70,572,252(+) GTTCC(A/C/G)CTGCT utr-variant-3-prime
rs1801461 -- 70,572,076(+) CCCCA(A/T)TCCCC utr-variant-3-prime
rs2168606 -- 70,575,949(+) GGTGG(C/T)TCATG utr-variant-3-prime
rs2168607 -- 70,576,371(+) TCCCA(C/T)CTCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SF3B3 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv833272 CNV Loss 17160897
nsv103855 CNV Loss 16902084

Relevant External Links for SF3B3 Gene

HapMap Linkage Disequilibrium report
SF3B3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SF3B3 Gene

Disorders for SF3B3 Gene

Relevant External Links for SF3B3

Genetic Association Database (GAD)
SF3B3
Human Genome Epidemiology (HuGE) Navigator
SF3B3

No disorders were found for SF3B3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SF3B3 Gene

Publications for SF3B3 Gene

  1. Characterization of a protein complex containing spliceosomal proteins saps 49,130,145 and 155. (PMID: 10490618) Das B.K. … Reed R. (Mol. Cell. Biol. 1999) 2 3 4
  2. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. (PMID: 11406595) Brand M. … Tora L. (EMBO J. 2001) 3 23
  3. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 3 4
  4. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PMID: 11564863) Martinez E. … Roeder R.G. (Mol. Cell. Biol. 2001) 3 4
  5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4

Products for SF3B3 Gene

  • Addgene plasmids for SF3B3

Sources for SF3B3 Gene

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