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SF3B3 Gene

protein-coding   GIFtS: 65
GCID: GC16P070557

Splicing Factor 3b, Subunit 3, 130kDa

(Previous names: splicing factor 3b, subunit 3, 130kD)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Splicing Factor 3b, Subunit 3, 130kDa1 2     Splicing Factor 3b, Subunit 3, 130kD1
SAP1302 3 5     RSE12
Pre-MRNA-Splicing Factor SF3b 130 KDa Subunit2 3     Pre-MRNA Splicing Factor SF3b, 130 KDa Subunit2
Spliceosome-Associated Protein 1302 3     Splicing Factor 3B Subunit 32
SF3b1302 3     KIAA00173
STAF1302 3     SF3B1305
SAP 1302 3     

External Ids:    HGNC: 107701   Entrez Gene: 234502   Ensembl: ENSG000001890917   OMIM: 6055925   UniProtKB: Q153933   

Export aliases for SF3B3 gene to outside databases

Previous GC identifers: GC16P061259 GC16P070978 GC16P070293 GC16P070333 GC16P069115 GC16P056388


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SF3B3 Gene:
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing
factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing
factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may
anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome.
Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription
coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing
complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SF3B3 Gene:
SF3B3 (splicing factor 3b, subunit 3, 130kDa) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is DDB1.

UniProtKB/Swiss-Prot: SF3B3_HUMAN, Q15393
Function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2
snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream
of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of
the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare
class of nuclear pre-mRNA intron

Gene Wiki entry for SF3B3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SF3B3 gene promoter:
         RFX1   FOXF2   AP-4   XBP-1   POU6F1 (c2)   E4BP4   RORalpha2   AREB6   FOXC1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSF3B3 promoter sequence
   Search Chromatin IP Primers for SF3B3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SF3B3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22

SF3B3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SF3B3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P070557:  view genomic region     (about GC identifiers)

Start:
70,557,691 bp from pter      End:
70,611,571 bp from pter
Size:
53,881 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SF3B3_HUMAN, Q15393 (See protein sequence)
Recommended Name: Splicing factor 3B subunit 3  
Size: 1217 amino acids; 135577 Da
Subunit: Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type
spliceosome. Component of splicing factor SF3B which is composed of at least eight subunits;
SF3B1/SAP155/SF3B155, SF3B2/SAP145/SF3B145, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B,
SF3B10 and SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear
ribonucleoproteins complex (U2 snRNP). Interaction between SF3B3 and SF3B1 is tighter than the interaction
between SF3B3 and SF3B2. Associates with the STAGA transcription coactivator-HAT complex. Interacts with SUPT3H
Sequence caution: Sequence=BAA02805.1; Type=Erroneous initiation; Sequence=BAA32662.2; Type=Erroneous initiation;
Secondary accessions: Q6NTI8 Q96GC0 Q9BPY2 Q9UFX7 Q9UJ29
Alternative splicing: 3 isoforms:  Q15393-1   Q15393-2   Q15393-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SF3B3: NX_Q15393

Explore proteomics data for SF3B3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys109, Lys139, Lys546, Lys812, Lys936, Lys965, Lys1049, Lys1074, Lys1171
  • Modification sites at PhosphoSitePlus

  • See SF3B3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036558.3  
    ENSEMBL proteins: 
     ENSP00000305790   ENSP00000454308   ENSP00000461236   ENSP00000463359   ENSP00000461342  
     ENSP00000464126   ENSP00000463253  
    Reactome Protein details: Q15393

    SF3B3 Human Recombinant Protein Products:

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    Novus Biologicals SF3B3 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SF3B3

     
    Search eBioscience for Proteins for SF3B3 

     
    antibodies-online proteins for SF3B3 (2 products) 

     
    antibodies-online peptides for SF3B3

    SF3B3 Antibody Products:

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    antibodies-online antibodies for SF3B3 (45 products) 

    SF3B3 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004871 Cleavage/polyA-sp_fac_asu_C
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q15393

    ProtoNet protein and cluster: Q15393

    1 Blocks protein domain: IPB004871 CPSF A subunit C-terminal

    UniProtKB/Swiss-Prot: SF3B3_HUMAN, Q15393
    Similarity: Belongs to the RSE1 family


    Find genes that share domains with SF3B3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SF3B3_HUMAN, Q15393
    Function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2
    snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream
    of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of
    the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare
    class of nuclear pre-mRNA intron

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SF3B3           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for SF3B3:
     Decreased cell number, increas  Decreased influenza A virus in  Decreased number of cells in m  Decreased viability 
     Decreased viability of wild-ty  G2 arrest  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SF3B3

    miRNA
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    miRTarBase miRNAs that target SF3B3:
    hsa-mir-10a-5p (MIRT047659), hsa-mir-221-3p (MIRT046961), hsa-mir-615-3p (MIRT039913), hsa-mir-15b-5p (MIRT046492), hsa-mir-342-3p (MIRT043737), hsa-mir-423-5p (MIRT038171), hsa-mir-484 (MIRT041733), hsa-mir-100-5p (MIRT048571), hsa-mir-30a-3p (MIRT049912), hsa-mir-222-3p (MIRT046744), hsa-mir-92a-3p (MIRT049223), hsa-mir-320a (MIRT044771), hsa-mir-30a-5p (MIRT028585), hsa-mir-26b-5p (MIRT029634), hsa-mir-193b-3p (MIRT041279), hsa-mir-423-3p (MIRT042599), hsa-mir-16-5p (MIRT051145), hsa-mir-324-3p (MIRT042941), hsa-mir-503-5p (MIRT041126)

    Block miRNA regulation of human, mouse, rat SF3B3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SF3B3 (see all 65):
    hsa-miR-26a-2* hsa-miR-411 hsa-miR-1260b hsa-miR-1243 hsa-miR-3649 hsa-miR-510 hsa-miR-30b* hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidSF3B3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SF3B3
    Predesigned siRNA for gene silencing in human, mouse, rat SF3B3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SF3B3 (NM_012426)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SF3B3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B3
    Addgene plasmids for SF3B3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3B3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SF3B3_HUMAN, Q15393: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex TAS10490618
    GO:0005689U12-type spliceosomal complex IDA15146077
    GO:0030532small nuclear ribonucleoprotein complex TAS10490618

    Find genes that share ontologies with SF3B3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SF3B3 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA processing0.44
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    mRNA Splicing0.78
    2Gene Expression
    Gene Expression0.40
    3Packaging Of Telomere Ends
    Histone modification0.31
    4Spliceosome
    Spliceosome


    Find genes that share SuperPaths with SF3B3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SF3B3
        mRNA processing

    2 Reactome Pathways for SF3B3
        mRNA Splicing - Major Pathway
    mRNA Splicing - Minor Pathway


    1 Kegg Pathway  (Kegg details for SF3B3):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SF3B3
    Interactions:

        Search GeneGlobe Interaction Network for SF3B3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SF3B3 (Q153932, 3 ENSP000003057904) via UniProtKB, MINT, STRING, and/or I2D (see all 1147)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3B1O755332, 3, ENSP000003353214MINT-7945693 MINT-6488590 MINT-6489355 MINT-7947479 MINT-8207078 MINT-6488791 I2D: score=8 STRING: ENSP00000335321
    EEF1A1P681042, 3MINT-6542674 MINT-7945693 MINT-6489539 MINT-6488590 MINT-6489355 MINT-7947479 MINT-6488791 I2D: score=1 
    PRPF8Q6P2Q92, 3, ENSP000003043504MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000304350
    SNRPD3P623182, 3, ENSP000002158294MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000215829
    NCOR1O753762, 3, ENSP000002687124MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000268712
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000375RNA splicing, via transesterification reactions TAS10490618
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing TAS10490618
    GO:0006461protein complex assembly TAS10490618
    GO:0008380RNA splicing TAS--

    Find genes that share ontologies with SF3B3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SF3B3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SF3B3 gene: 
    NM_012426.4  

    Unigene Cluster for SF3B3:

    Splicing factor 3b, subunit 3, 130kDa
    Hs.514435  [show with all ESTs]
    Unigene Representative Sequence: NM_012426
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302516(uc002ezf.3) ENST00000566095 ENST00000577085 ENST00000567654
    ENST00000564899 ENST00000569687 ENST00000572365 ENST00000567635 ENST00000567250
    ENST00000568291 ENST00000568539 ENST00000563739 ENST00000562722 ENST00000565990

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SF3B3 (see all 65):
    hsa-miR-26a-2* hsa-miR-411 hsa-miR-1260b hsa-miR-1243 hsa-miR-3649 hsa-miR-510 hsa-miR-30b* hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidSF3B3 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: SF3B3 (NM_012426)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SF3B3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B3
    Addgene plasmids for SF3B3 
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SF3B3
      QuantiFast Probe-based Assays in human, mouse, rat SF3B3

    Additional mRNA sequence: 

    AJ001443.1 AK001297.1 AK074933.1 AK291768.1 AL110251.1 BC000463.1 BC003146.1 BC009780.1 
    BC068974.1 D13642.1 D87686.1 

    Selected DOTS entries (see all 34):

    DT.100664337  DT.91726090  DT.219320  DT.100664338  DT.100664336  DT.95162443  DT.92456004  DT.95327493 
    DT.97823642  DT.100664340  DT.91752651  DT.99961658  DT.100664333  DT.102835122  DT.40193413  DT.75167598 
    DT.92455989  DT.95325424  DT.100664334  DT.100673181  DT.101956378  DT.101957658  DT.120690605  DT.120690645 

    Selected AceView cDNA sequences (see all 624):

    BM764965 T28698 CB105577 BE889958 BU553203 AV718134 CA390621 BU557244 
    BU196819 AA588793 AL041351 AA429221 CA436724 BG286418 CR622673 BQ958437 
    BM852294 BQ070756 BQ070068 AW205423 AA293721 CB105593 AA331459 BM663355 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SF3B3 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a ·
    SP1:              -     -                 -                                                                                                                     
    SP2:                                                                                                                                                        -   
    SP3:                                                                                                                                                            
    SP4:              -     -                 -                                                                                                                     
    SP5:              -                       -                                                                                                                     

    ExUns: 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b
    SP1:  -           -                 -                                                           -           -                           
    SP2:  -     -     -     -     -     -                                                                                                   
    SP3:  -           -     -     -     -                                                                                                   
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for SF3B3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SF3B3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCCAGGTT
    SF3B3 Expression
    About this image

    SF3B3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SF3B3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514435
        Custom PCR Arrays for SF3B3
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SF3B3 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sf3b31 , 5 splicing factor 3b, subunit 31, 5 90.77(n)1
    99.92(a)1
      8 (57.73 cM)5
    1019431  NM_133953.21  NP_598714.11 
     1108104925 
    chicken
    (Gallus gallus)
    Aves SF3B31 splicing factor 3b, subunit 3, 130kDa 82.74(n)
    99.18(a)
      415680  XM_004944119.1  XP_004944176.1 
    lizard
    (Anolis carolinensis)
    Reptilia SF3B36
    splicing factor 3b, subunit 3, 130kDa
    99(a)
    1 ↔ 1
    GL343539.1(79562-108340)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76172 Xenopus laevis transcribed sequence with moderate similarity more 78.62(n)    BU911752.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb81f052 Danio rerio mRNA similar to splicing factor 3b, subunit more 78.85(n)    BC047171.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG139001 , 3 mRNA splicing damaged DNA binding3
    CG139001
    75(a)3
    66.56(n)1
    75.76(a)1
      61D23
    380931  NM_167842.21  NP_728546.11 
    worm
    (Caenorhabditis elegans)
    Secernentea K02F2.33
    teg-41
    teg-41 60(a)3
    59.46(n)1
    61.67(a)1
      I(6822596-6842468)3
    1724061  NM_059552.31  NP_491953.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSE1(YML049C)4 Protein involved in pre-mRNA splicing; component of more   --   13(178305-174220) 854956  NP_013663.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G552001 AT3G55200 59.86(n)
    59.13(a)
      824686  NM_115378.3  NP_567015.1 
    rice
    (Oryza sativa)
    Liliopsida Os.178192 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.55(n)    AK068480.1 


    ENSEMBL Gene Tree for SF3B3 (if available)
    TreeFam Gene Tree for SF3B3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SF3B3 gene
    DDB12  

    Find genes that share paralogs with SF3B3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SF3B3 (see all 992)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80496411,2
    C,F,A,H--70559548(+) GTTTTC/ACTGTG 1 -- int123Minor allele frequency- A:0.39NS EA NA WA CSA 2480
    rs1506128461,2
    --70559585(+) AGTCTA/GTGGGC 1 -- int10--------
    rs348909621,2
    C,F--70559666(-) GTCTCC/GATCTC 1 -- int13Minor allele frequency- G:0.40NA CSA 5
    rs80501961,2
    C--70559882(+) aaaaaT/Aaggaa 1 -- int1 trp31Minor allele frequency- A:0.00WA 2
    rs2014538371,2
    C--70559896(-) TATATC/TTTTTT 1 -- int10--------
    rs1446709811,2
    --70559968(+) TCTTGC/TCACCC 1 -- int10--------
    rs80520311,2
    C,A--70560121(+) TATTTA/TTTTTT 1 -- int1 trp36Minor allele frequency- T:0.37WA CSA NA EA 363
    rs1479056391,2
    C--70560236(+) CTCCCG/TAGTAG 1 -- int10--------
    rs1417143311,2
    --70560253(+) CTACAG/TGCGCA 1 -- int10--------
    rs1468297451,2
    C--70560308(+) GTTTCA/GCTGTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for SF3B3 (70557691 - 70611571 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SF3B3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833272CNV Loss17160897
    nsv103855CNV Loss16902084
    nsv7285OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SF3B3
    DNA2.0 Custom Variant and Variant Library Synthesis for SF3B3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605592    OMIM disorders: --


    Find genes that share disorders with SF3B3           About GenesLikeMe

    Genetic Association Database (GAD): SF3B3
    Human Genome Epidemiology (HuGE) Navigator: SF3B3 (1 document)

    Export disorders for SF3B3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SF3B3 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with SF3B3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a protein complex containing spliceosomal proteins saps 49,130,145 and 155. (PubMed id 10490618)1, 2, 3 Das B.K.... Reed R. (Mol. Cell. Biol. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (RNA 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    6. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PubMed id 12234937)1, 2 Will C.L.... Luehrmann R. (EMBO J. 2002)
    7. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)1, 2 Martinez E.... Roeder R.G. (Mol. Cell. Biol. 2001)
    8. The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger. (PubMed id 11438666)1, 2 Gangloff Y.G.... Davidson I. (Mol. Cell. Biol. 2001)
    9. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    10. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. (PubMed id 11406595)1, 9 Brand M....Tora L. (EMBO J. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23450 HGNC: 10770 AceView: SF3B3 Ensembl:ENSG00000189091 euGenes: HUgn23450
    ECgene: SF3B3 Kegg: 23450 H-InvDB: SF3B3

    (According to HUGE)
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    HUGE: KIAA0017

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SF3B3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SF3B3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SF3B3 gene:
    Search GeneIP for patents involving SF3B3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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