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Aliases for SF3B2 Gene

Aliases for SF3B2 Gene

  • Splicing Factor 3b, Subunit 2, 145kDa 2 3
  • SF3B145 3 4 6
  • SAP145 3 4 6
  • Pre-MRNA-Splicing Factor SF3b 145 KDa Subunit 3 4
  • Splicing Factor 3b, Subunit 2, 145kD 2 3
  • Spliceosome-Associated Protein 145 3 4
  • SAP 145 3 4
  • SF3b150 3 4
  • Pre-MRNA Splicing Factor SF3b 145 KDa Subunit 3
  • Spliceosome Associated Protein 145 3
  • Splicing Factor 3B Subunit 2 3
  • SF3b1 3
  • Cus1 3

External Ids for SF3B2 Gene

Previous GeneCards Identifiers for SF3B2 Gene

  • GC11P068353
  • GC11P067501
  • GC11P066069
  • GC11P065594
  • GC11P065576
  • GC11P065825
  • GC11P065827
  • GC11P062145

Summaries for SF3B2 Gene

Entrez Gene Summary for SF3B2 Gene

  • This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for SF3B2 Gene

SF3B2 (Splicing Factor 3b, Subunit 2, 145kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SF3B2 Gene

  • Subunit of the splicing factor SF3B required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron

Gene Wiki entry for SF3B2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SF3B2 Gene

Genomics for SF3B2 Gene

Regulatory Elements for SF3B2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SF3B2 Gene

Start:
66,050,729 bp from pter
End:
66,069,308 bp from pter
Size:
18,580 bases
Orientation:
Plus strand

Genomic View for SF3B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SF3B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SF3B2 Gene

Proteins for SF3B2 Gene

  • Protein details for SF3B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13435-SF3B2_HUMAN
    Recommended name:
    Splicing factor 3B subunit 2
    Protein Accession:
    Q13435
    Secondary Accessions:
    • A8K485
    • B4DT19
    • Q7L4T5
    • Q7Z627
    • Q969K1
    • Q96CM6
    • Q9BWD2

    Protein attributes for SF3B2 Gene

    Size:
    895 amino acids
    Molecular mass:
    100228 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155, SF3B2/SAP145/SF3B145, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). SF3B2 interacts directly with SF3B4. Interacts with HIV-1 Vpr.
    SequenceCaution:
    • Sequence=AAA97461.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA97461.1; Type=Frameshift; Positions=28; Evidence={ECO:0000305}; Sequence=AAH53577.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAG61831.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SF3B2 Gene

neXtProt entry for SF3B2 Gene

Proteomics data for SF3B2 Gene at MOPED

Post-translational modifications for SF3B2 Gene

  • Ubiquitination at Lys275, Lys280, Lys466, Lys486, Lys492, Lys529, Lys570, Lys577, and Lys790
  • Modification sites at PhosphoSitePlus

Other Protein References for SF3B2 Gene

No data available for DME Specific Peptides for SF3B2 Gene

Domains for SF3B2 Gene

Protein Domains for SF3B2 Gene

Suggested Antigen Peptide Sequences for SF3B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13435

UniProtKB/Swiss-Prot:

SF3B2_HUMAN :
  • Q13435
Domain:
  • Contains 1 SAP domain.
genes like me logo Genes that share domains with SF3B2: view

No data available for Gene Families for SF3B2 Gene

Function for SF3B2 Gene

Molecular function for SF3B2 Gene

UniProtKB/Swiss-Prot Function: Subunit of the splicing factor SF3B required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron

Gene Ontology (GO) - Molecular Function for SF3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SF3B2: view
genes like me logo Genes that share phenotypes with SF3B2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SF3B2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SF3B2 Gene

Localization for SF3B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SF3B2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SF3B2 Gene COMPARTMENTS Subcellular localization image for SF3B2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SF3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005689 U12-type spliceosomal complex IDA 15146077
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with SF3B2: view

Pathways for SF3B2 Gene

genes like me logo Genes that share pathways with SF3B2: view

Pathways by source for SF3B2 Gene

1 KEGG pathway for SF3B2 Gene

Gene Ontology (GO) - Biological Process for SF3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing TAS 8566756
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with SF3B2: view

Transcripts for SF3B2 Gene

Unigene Clusters for SF3B2 Gene

Splicing factor 3b, subunit 2, 145kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SF3B2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SF3B2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SF3B2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a ·
SP1: - - -
SP2: - - - - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - -
SP7:
SP8:
SP9:
SP10: -
SP11:

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SF3B2 Gene

GeneLoc Exon Structure for
SF3B2
ECgene alternative splicing isoforms for
SF3B2

Expression for SF3B2 Gene

mRNA expression in normal human tissues for SF3B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SF3B2 Gene

SOURCE GeneReport for Unigene cluster for SF3B2 Gene Hs.406423

genes like me logo Genes that share expressions with SF3B2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SF3B2 Gene

Orthologs for SF3B2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SF3B2 35
  • 99.81 (n)
  • 100 (a)
SF3B2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SF3B2 35
  • 91.52 (n)
  • 97.76 (a)
SF3B2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SF3B2 35
  • 92.86 (n)
  • 98.77 (a)
SF3B2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sf3b2 35
  • 89.67 (n)
  • 97.72 (a)
Sf3b2 16
Sf3b2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SF3B2 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sf3b2 35
  • 89.79 (n)
  • 98.18 (a)
lizard
(Anolis carolinensis)
Reptilia SF3B2 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6684 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sf3b2 35
  • 71.83 (n)
  • 80.6 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9085 35
zebrafish
(Danio rerio)
Actinopterygii sf3b2 35
  • 72.28 (n)
  • 78.66 (a)
sf3b2 36
  • 71 (a)
OneToOne
wufb53c07 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006240 35
  • 64.68 (n)
  • 66.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3605 35
  • 63.55 (n)
  • 64.77 (a)
CG3605 36
  • 51 (a)
OneToOne
CG3605 37
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_W03F9.10 35
  • 57.79 (n)
  • 54.83 (a)
W03F9.10 36
  • 49 (a)
OneToOne
W03F9.10 37
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CUS1 36
  • 30 (a)
OneToOne
CUS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G21660 35
  • 56.47 (n)
  • 53.52 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.9620 35
corn
(Zea mays)
Liliopsida Zm.837 35
rice
(Oryza sativa)
Liliopsida Os.26501 35
Os02g0827300 35
  • 55.92 (n)
  • 51.72 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.160 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10434 36
  • 62 (a)
OneToOne
Species with no ortholog for SF3B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SF3B2 Gene

ENSEMBL:
Gene Tree for SF3B2 (if available)
TreeFam:
Gene Tree for SF3B2 (if available)

Paralogs for SF3B2 Gene

Selected SIMAP similar genes for SF3B2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SF3B2: view

No data available for Paralogs for SF3B2 Gene

Variants for SF3B2 Gene

Sequence variations from dbSNP and Humsavar for SF3B2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs477280 -- 66,067,780(-) TGGGC(G/T)GGGGG intron-variant
rs491618 -- 66,058,480(-) TGAAC(A/T)CTTAC intron-variant
rs493320 -- 66,064,896(-) ataaa(G/T)aattt intron-variant
rs503156 -- 66,053,202(+) atgtg(A/G)caccc intron-variant
rs504742 -- 66,062,234(-) ATCTT(G/T)GTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SF3B2 Gene

Variant ID Type Subtype PubMed ID
dgv1186n71 CNV Loss 21882294
nsv897770 CNV Loss 21882294

Relevant External Links for SF3B2 Gene

HapMap Linkage Disequilibrium report
SF3B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SF3B2 Gene

Disorders for SF3B2 Gene

No disorders were found for SF3B2 Gene.

No data available for UniProtKB/Swiss-Prot for SF3B2 Gene

Publications for SF3B2 Gene

  1. Human immunodeficiency virus type 1 Vpr induces G2 checkpoint activation by interacting with the splicing factor SAP145. (PMID: 16923959) Terada Y. … Yasuda Y. (Mol. Cell. Biol. 2006) 3 4 23
  2. Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A. (PMID: 8566756) Gozani O. … Reed R. (Genes Dev. 1996) 2 3 4
  3. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. (PMID: 10882114) Das R. … Reed R. (Mol. Cell 2000) 3 4
  4. The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. (PMID: 7958871) Champion-Arnaud P. … Reed R. (Genes Dev. 1994) 3 23
  5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4

Products for SF3B2 Gene

Sources for SF3B2 Gene

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