Aliases for SF3B2 Gene
Aliases for SF3B2 Gene
External Ids for SF3B2 Gene
- HGNC: 10769
- Entrez Gene: 10992
- Ensembl: ENSG00000087365
- OMIM: 605591
- UniProtKB: Q13435
Previous GeneCards Identifiers for SF3B2 Gene
- GC11P068353
- GC11P067501
- GC11P066069
- GC11P065594
- GC11P065576
- GC11P065825
- GC11P065827
- GC11P062145
Summaries for SF3B2 Gene
-
This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]
GeneCards Summary for SF3B2 Gene
SF3B2 (Splicing Factor 3b Subunit 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.
UniProtKB/Swiss-Prot for SF3B2 Gene
-
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the E complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).
Additional gene information for SF3B2 Gene
- Monarch Initiative
- Search for SF3B2 at DataMed
- Search for SF3B2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SF3B2 Gene
Genomics for SF3B2 Gene
GeneHancer (GH) Regulatory Elements for SF3B2 Gene
Promoters and enhancers for SF3B2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SF3B2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SF3B2 Gene
Genomic Locations for SF3B2 Gene
- chr11:66,050,729-66,069,308
- (GRCh38/hg38)
- Size:
- 18,580 bases
- Orientation:
- Plus strand
- chr11:65,818,200-65,836,779
- (GRCh37/hg19)
Genomic View for SF3B2 Gene
Genes around SF3B2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
SF3B2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SF3B2 Gene
Proteins for SF3B2 Gene
-
Protein details for SF3B2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13435-SF3B2_HUMAN
- Recommended name:
- Splicing factor 3B subunit 2
- Protein Accession:
- Q13435
- A8K485
- B4DT19
- Q7L4T5
- Q7Z627
- Q969K1
- Q96CM6
- Q9BWD2
Protein attributes for SF3B2 Gene
- Size:
- 895 amino acids
- Molecular mass:
- 100228 Da
- Quaternary structure:
-
- Identified in the spliceosome C complex (PubMed:11991638). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077). Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A and DDX42 (PubMed:12234937, PubMed:12738865, PubMed:27720643, PubMed:28541300). SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP) (PubMed:12234937). Interacts directly with SF3B4 (PubMed:25737013). The SF3B complex composed of SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6 and PHF5A interacts with U2AF2 (PubMed:27720643). Found in a complex with PRMT9, SF3B2 and SF3B4 (PubMed:25737013). Interacts with HIV-1 Vpr (PubMed:16923959). Interacts (Arg-508-methylated form) with SMN1 (via Tudor domain) (PubMed:25737013). Interacts with RBM7 (PubMed:27905398).
- SequenceCaution:
-
- Sequence=AAA97461.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA97461.1; Type=Frameshift; Positions=28; Evidence={ECO:0000305}; Sequence=AAH53577.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAG61831.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for SF3B2 Gene
Post-translational modifications for SF3B2 Gene
- Methylation at Arg-508 by PRMT9 is required for the interaction with SMN1.
- Ubiquitination at isoforms=280, posLast=466466, posLast=486486, posLast=492492, posLast=529529, posLast=570570, isoforms=577, and isoforms=790
Other Protein References for SF3B2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SF3B2
- Novus Biologicals Antibodies for SF3B2
-
Abcam antibodies for SF3B2
- Invitrogen Antibodies for SF3B2
- Search GeneTex for Antibodies for SF3B2
-
Santa Cruz Biotechnology (SCBT) Antibodies for SF3B2
Protein Products
-
OriGene Purified Proteins for SF3B2
- Search Origene for MassSpec and Protein Over-expression Lysates for SF3B2
- Origene Custom Protein Services for SF3B2
- antibodies-online: Search results for 4 available SF3B2 Proteins ranked by validation data
- Compare Top SF3B2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for SF3B2
-
Abcam proteins for SF3B2
Assay Products
No data available for DME Specific Peptides for SF3B2 Gene
Domains & Families for SF3B2 Gene
Gene Families for SF3B2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SF3B2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SF3B2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for SF3B2 Gene
Function for SF3B2 Gene
Molecular function for SF3B2 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the E complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).
Phenotypes From GWAS Catalog for SF3B2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA,IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for SF3B2 Gene
- GenomeRNAi human phenotypes for SF3B2:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased NF-kappaB reporter expression
- Resistant to vaccinia virus (VACV-A4L) infection
- FOXO1 nuclear localization
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Decreased shRNA abundance
- Decreased influenza A virus infection
- Decreased viability of wild-type and TP53 knockout cells
- Decreased HIV-1 infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SF3B2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SF3B2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SF3B2 gene
- Search ViGene Biosciences for SF3B2
CRISPR Products
-
OriGene CRISPR knockouts for SF3B2
- genomics-online: gRNA clones - Search results for available SF3B2 gene related products
- Applied Biological Materials CRISPR for SF3B2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SF3B2
- GenScript: Design CRISPR guide RNA sequences for SF3B2
miRNA for SF3B2 Gene
- miRTarBase miRNAs that target SF3B2
-
- hsa-mir-26b-5p (MIRT029398)
- hsa-mir-877-3p (MIRT036927)
- hsa-mir-93-3p (MIRT038862)
- hsa-mir-615-3p (MIRT039791)
- hsa-mir-18a-3p (MIRT040893)
- hsa-mir-193b-3p (MIRT041282)
- hsa-mir-484 (MIRT041928)
- hsa-mir-324-5p (MIRT043182)
- hsa-mir-331-3p (MIRT043563)
- hsa-mir-342-3p (MIRT043738)
- hsa-mir-3189-3p (MIRT731218)
miRNA Products
- Search ViGene Biosciences for SF3B2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SF3B2
- Browse OriGene Inhibitory RNA Products For SF3B2
- genomics-online: shRNA clones - Search results for available SF3B2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SF3B2 gene
Clone Products
- Sino Biological Human cDNA Clone for SF3B2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SF3B2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SF3B2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SF3B2
- genomics-online: cdna clones - Search results for available SF3B2 gene related products
- orf clones - Search results for available SF3B2 gene related products
- Applied Biological Materials Clones for SF3B2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SF3B2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SF3B2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SF3B2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SF3B2 Gene
Localization for SF3B2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SF3B2 Gene
- Nucleus. Nucleus speckle.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nuclear speckles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IDA | 9731529 |
| GO:0005684 | U2-type spliceosomal complex | IBA | -- |
| GO:0005686 | U2 snRNP | IBA | -- |
Pathways & Interactions for SF3B2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.50
.41
|
| 2 | Gene Expression |
.48
|
|
| 3 | mRNA Splicing - Minor Pathway | ||
Pathways by source for SF3B2 Gene
1 BioSystems pathway for SF3B2 Gene
5 Reactome pathways for SF3B2 Gene
1 KEGG pathway for SF3B2 Gene
Interacting Proteins for SF3B2 Gene
Selected Interacting proteins:
Q13435-SF3B2_HUMAN
ENSP00000318861
for SF3B2 Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006397 | mRNA processing | TAS | 8566756 |
| GO:0008380 | RNA splicing | TAS | 8566756 |
| GO:0016032 | viral process | IEA | -- |
No data available for SIGNOR curated interactions for SF3B2 Gene
Transcripts for SF3B2 Gene
mRNA/cDNA for SF3B2 Gene
- (4) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (854) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SF3B2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SF3B2
- genomics-online: gRNA clones - Search results for available SF3B2 gene related products
- Applied Biological Materials CRISPR for SF3B2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SF3B2
- GenScript: Design CRISPR guide RNA sequences for SF3B2
miRNA Products
- Search ViGene Biosciences for SF3B2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SF3B2
- Browse OriGene Inhibitory RNA Products For SF3B2
- genomics-online: shRNA clones - Search results for available SF3B2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SF3B2 gene
Clone Products
- Sino Biological Human cDNA Clone for SF3B2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SF3B2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SF3B2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SF3B2
- genomics-online: cdna clones - Search results for available SF3B2 gene related products
- orf clones - Search results for available SF3B2 gene related products
- Applied Biological Materials Clones for SF3B2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 | ^ | 12 | ^ | 13a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||
| SP11: |
Expression for SF3B2 Gene
This gene is overexpressed in Nasal epithelium (9.2) and Peripheral blood mononuclear cells (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SF3B2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SF3B2 Gene:
SF3B2SOURCE GeneReport for Unigene cluster for SF3B2 Gene:
Hs.406423Evidence on tissue expression from TISSUES for SF3B2 Gene
- Eye(4.8)
- Lung(4.8)
- Liver(4.6)
- Blood(4.5)
- Kidney(4.4)
- Nervous system(4.3)
- Intestine(2.8)
- Skin(2.8)
- Thyroid gland(2.7)
- Pancreas(2.5)
- Heart(2.1)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs for SF3B2
- genomics-online: primer clones - Search results for available SF3B2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SF3B2 Gene
Orthologs for SF3B2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SF3B2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SF3B2 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | SF3B2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Sf3b2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Sf3b2 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SF3B2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SF3B2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sf3b2 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6684 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | sf3b2 33 34 |
|
||
| wufb53c07 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9085 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006240 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG3605 35 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | CELE_W03F9.10 33 |
|
||
| W03F9.10 35 34 |
|
||||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CUS1 34 36 |
|
OneToOne | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G21660 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0827300 33 |
|
||
| Os.26501 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.9620 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.837 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10434 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.160 33 |
|
- Species where no ortholog for SF3B2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SF3B2 Gene
(1) SIMAP similar genes for SF3B2 Gene using alignment to 7 proteins:
No data available for Paralogs for SF3B2 Gene
Variants for SF3B2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057519959 | likely-pathogenic, Malignant melanoma of skin, Chronic lymphocytic leukemia, Hepatocellular carcinoma, Neoplasm of the breast | 66,063,028(+) | A/C | coding_sequence_variant, missense_variant | |
| rs1057519960 | likely-pathogenic, Chronic lymphocytic leukemia, Myelodysplastic syndrome, Pancreatic adenocarcinoma, Neoplasm of the breast, Acute myeloid leukemia, Medulloblastoma, Renal cell carcinoma | 66,063,413(+) | A/G | coding_sequence_variant, missense_variant | |
| rs1000004252 | -- | 66,065,633(+) | C/T | intron_variant | |
| rs1000119972 | -- | 66,065,308(+) | C/T | intron_variant | |
| rs1000122418 | -- | 66,054,829(+) | C/T | intron_variant |
Residual Variation Intolerance Score:
4.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.60;
56.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SF3B2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SF3B2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SF3B2 Gene
Disorders for SF3B2 Gene
Additional Disease Information for SF3B2
No disorders were found for SF3B2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SF3B2 Gene
Publications for SF3B2 Gene
- Human immunodeficiency virus type 1 Vpr induces G2 checkpoint activation by interacting with the splicing factor SAP145. (PMID: 16923959) Terada Y … Yasuda Y (Molecular and cellular biology 2006) 3 4 22 58
- Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A. (PMID: 8566756) Gozani O … Reed R (Genes & development 1996) 2 3 4 58
- Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. (PMID: 27905398) Falk S … Conti E (Nature communications 2016) 3 4 58
- PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. (PMID: 25737013) Yang Y … Bedford MT (Nature communications 2015) 3 4 58
- Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. (PMID: 25979344) Hadjikyriacou A … Clarke SG (The Journal of biological chemistry 2015) 3 4 58
Products for SF3B2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for SF3B2
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- OriGene Purified Proteins for SF3B2
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- GenScript: Next-day shipping of latest version cDNA ORF clones for SF3B2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for SF3B2
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- GenScript Custom overexpressing Cell Line Services for SF3B2
- GenScript: Design CRISPR guide RNA sequences for SF3B2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- Sino Biological Human cDNA Clone for SF3B2
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- Novus Biologicals Antibodies for SF3B2
- Novus Biologicals lysates and proteins for SF3B2
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- Novus Biologicals Tissue Microarrays
- Abcam antibodies for SF3B2
- Abcam proteins for SF3B2
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for SF3B2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for SF3B2
- VectorBuilder custom plasmid, inducible vectors for SF3B2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SF3B2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SF3B2
- antibodies-online: Search results for 54 available SF3B2 Antibodies ranked by validation data
- Compare Top SF3B2 Antibodies
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- antibodies-online: Search results for available SF3B2 related products ranked by validation data
- antibodies-online: Search results for 4 available SF3B2 Proteins ranked by validation data
- Compare Top SF3B2 Proteins
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- Search GeneTex for Antibodies for SF3B2
- Search GeneTex for Proteins for SF3B2
- ViGene Biosciences adenoviral particle packaged cDNA for SF3B2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SF3B2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SF3B2 gene
- Search ViGene Biosciences for SF3B2
- Santa Cruz Biotechnology (SCBT) Antibodies for SF3B2
- Search Santa Cruz Biotechnology (SCBT) for SF3B2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SF3B2
- genomics-online: cdna clones - Search results for available SF3B2 gene related products
- orf clones - Search results for available SF3B2 gene related products
- genomics-online: gRNA clones - Search results for available SF3B2 gene related products
- genomics-online: primer clones - Search results for available SF3B2 gene related products
- genomics-online: shRNA clones - Search results for available SF3B2 gene related products
Sources for SF3B2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew