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SF3B2 Gene

protein-coding   GIFtS: 59
GCID: GC11P065827

Splicing Factor 3b, Subunit 2, 145kDa

(Previous names: splicing factor 3b, subunit 2, 145kD)
  See related diseases
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Aliases
for SF3B2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Splicing Factor 3b, Subunit 2, 145kDa1 2     Splicing Factor 3b, Subunit 2, 145kD1
SAP1452 3 5     Cus12
Pre-MRNA-Splicing Factor SF3b 145 KDa Subunit2 3     SF3b12
Spliceosome-Associated Protein 1452 3     Pre-MRNA Splicing Factor SF3b 145 KDa Subunit2
SF3b1502 3     Spliceosome Associated Protein 1452
SAP 1452 3     Splicing Factor 3B Subunit 22
SF3B1452 5     SF3b1453

External Ids:    HGNC: 107691   Entrez Gene: 109922   Ensembl: ENSG000000873657   OMIM: 6055915   UniProtKB: Q134353   

Export aliases for SF3B2 gene to outside databases

Previous GC identifers: GC11P068353 GC11P067501 GC11P066069 GC11P065594 GC11P065576 GC11P065825 GC11P062145


Summaries
for SF3B2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SF3B2 Gene:
This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing
factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing
factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may
anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome.
Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts
directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a
proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. (provided by RefSeq, Jul 2008)

GeneCards Summary for SF3B2 Gene:
SF3B2 (splicing factor 3b, subunit 2, 145kDa) is a protein-coding gene. Diseases associated with SF3B2 include leiomyoma, and herpes simplex. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot: SF3B2_HUMAN, Q13435
Function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2
snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream
of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of
the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare
class of nuclear pre-mRNA intron

Gene Wiki entry for SF3B2 Gene


Genomic Views
for SF3B2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SF3B2 gene promoter:
         Max1   RFX1   NF-1/L   NF-1   Elk-1   Pax-5   AP-1   ATF-2   MIF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SF3B2 promoter sequence
   Search Chromatin IP Primers for SF3B2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SF3B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

SF3B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SF3B2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P065827:  view genomic region     (about GC identifiers)

Start:
 65,818,200 bp from pter      End:
 65,836,779 bp from pter
Size:
 18,580 bases      Orientation:
 plus strand

Proteins
for SF3B2 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SF3B2_HUMAN, Q13435 (See protein sequence)
Recommended Name: Splicing factor 3B subunit 2  
Size: 895 amino acids; 100228 Da
Subunit: Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type
spliceosome. Component of splicing factor SF3B which is composed of at least eight subunits;
SF3B1/SAP155/SF3B155, SF3B2/SAP145/SF3B145, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B,
SF3B10 and SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear
ribonucleoproteins complex (U2 snRNP). SF3B2 interacts directly with SF3B4. Interacts with HIV-1 Vpr
Sequence caution: Sequence=AAA97461.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA97461.1; Type=Frameshift; Positions=28; Sequence=AAH53577.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAG61831.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for SF3B2:
2DO5 (3D)    
Secondary accessions: A8K485 B4DT19 Q7L4T5 Q7Z627 Q969K1 Q96CM6 Q9BWD2

Explore the universe of human proteins at neXtProt for SF3B2: NX_Q13435

Explore proteomics data for SF3B2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys275, Lys280, Lys466, Lys486, Lys492, Lys529, Lys570, Lys577, Lys790
  • Modification sites at PhosphoSitePlus

    • See SF3B2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006833.2  
    ENSEMBL proteins: 
     ENSP00000432655   ENSP00000318861   ENSP00000435495   ENSP00000431908   ENSP00000431520  
     ENSP00000435765   ENSP00000436757  
    Reactome Protein details: Q13435

    SF3B2 Human Recombinant Protein Products:

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    Novus Biologicals SF3B2 Proteins
    Novus Biologicals SF3B2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SF3B2

    SF3B2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for SF3B2
    Cloud-Clone Corp. Antibodies for SF3B2
    Search ThermoFisher Antibodies for SF3B2
    LSBio Antibodies in human, mouse, rat for SF3B2

    SF3B2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for SF3B2
    Cloud-Clone Corp. CLIAs for SF3B2

    Domains /
    Families
    for SF3B2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 3 InterPro protein domains:
     IPR006568 PSP
     IPR007180 DUF382
     IPR003034 SAP_dom

    Graphical View of Domain Structure for InterPro Entry Q13435

    ProtoNet protein and cluster: Q13435

    2 Blocks protein domains:
    IPB003034 DNA-binding SAP
    IPB006568 PSP


    UniProtKB/Swiss-Prot: SF3B2_HUMAN, Q13435
    Similarity: Contains 1 SAP domain


    SF3B2 for domains           About GeneDecksing


    Function
    for SF3B2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SF3B2_HUMAN, Q13435
    Function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2
    snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream
    of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of
    the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare
    class of nuclear pre-mRNA intron

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI16189514
    GO:0044822poly(A) RNA binding IDA--
         
    SF3B2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for SF3B2:
     Decreased influenza A virus in  Decreased viability  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SF3B2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SF3B2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SF3B2

    miRNA
    Products:            		miRTarBase miRNAs that target SF3B2:
    hsa-mir-484 (MIRT041928), hsa-mir-331-3p (MIRT043563), hsa-mir-193b-3p (MIRT041282), hsa-mir-93-3p (MIRT038862), hsa-mir-324-5p (MIRT043182), hsa-mir-26b-5p (MIRT029398), hsa-mir-18a-3p (MIRT040893), hsa-mir-877-3p (MIRT036927), hsa-mir-615-3p (MIRT039791), hsa-mir-342-3p (MIRT043738)

    Block miRNA regulation of human, mouse, rat SF3B2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SF3B2:
    hsa-miR-4261 hsa-miR-520d-5p hsa-miR-130b* hsa-miR-524-5p hsa-miR-548b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SF3B2 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for SF3B2
    Predesigned siRNA for gene silencing in human, mouse, rat SF3B2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SF3B2

    Clone
    Products:             		 OriGene clones in human, mouse for SF3B2 (see all 8)
    OriGene ORF clones in mouse, rat for SF3B2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SF3B2 (NM_006842)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SF3B2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B2

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SF3B2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SF3B2 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3B2


    Localization
    for SF3B2 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    SF3B2_HUMAN, Q13435: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005689U12-type spliceosomal complex IDA15146077
    GO:0005730NOT nucleolus IDA--

    SF3B2 for ontologies           About GeneDecksing


    Pathways & Interactions
    for SF3B2 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    SuperPaths for SF3B2 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    		mRNA Splicing - Major Pathway0.78
    		mRNA processing0.44
    		Processing of Capped Intron-Containing Pre-mRNA0.78
    		mRNA Splicing - Minor Pathway0.38
    		mRNA Splicing0.78
    2Gene Expression
    		Gene Expression0.40
    3Spliceosome
    		Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SF3B2
        mRNA processing

    2 Reactome Pathways for SF3B2
        mRNA Splicing - Major Pathway
    mRNA Splicing - Minor Pathway


    1 Kegg Pathway  (Kegg details for SF3B2):
        Spliceosome


    SF3B2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SF3B2
    Interactions:

        GeneGlobe Interaction Network for SF3B2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SF3B2 (Q134351, 2, 3 ENSP000003188614) via UniProtKB, MINT, STRING, and/or I2D (see all 978)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3B4Q154271, 2, 3, ENSP000002716284EBI-749111,EBI-348469 MINT-7945693 MINT-8332328 MINT-8333515 I2D: score=5 STRING: ENSP00000271628
    SF3B1O755332, 3, ENSP000003353214MINT-7945693 MINT-6488590 MINT-6489355 MINT-7947479 MINT-8207078 I2D: score=1 STRING: ENSP00000335321
    PRPF8Q6P2Q91, 2, ENSP000003043504EBI-749111,EBI-538479 MINT-7945693 MINT-8333548 MINT-8331789 MINT-7947479 MINT-8332339 STRING: ENSP00000304350
    SF3A2Q154282, 3, ENSP000002214944MINT-5205476 MINT-7947479 I2D: score=2 STRING: ENSP00000221494
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000326261
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing TAS8566756
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--
    GO:0016032viral process IEA--

    SF3B2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SF3B2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SF3B2



    Transcripts
    for SF3B2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SF3B2 gene: 
    NM_006842.2  

    Unigene Cluster for SF3B2:

    Splicing factor 3b, subunit 2, 145kDa
    Hs.406423  [show with all ESTs]
    Unigene Representative Sequence: NM_006842
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529577 ENST00000534307 ENST00000528302 ENST00000322535(uc001ogx.1 uc001ogy.1)
    ENST00000524627 ENST00000533595 ENST00000531041 ENST00000531589 ENST00000530322
    ENST00000524475 ENST00000533421 ENST00000526653 ENST00000525207 ENST00000529994
    ENST00000530981 ENST00000534765
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat SF3B2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SF3B2:
    hsa-miR-4261 hsa-miR-520d-5p hsa-miR-130b* hsa-miR-524-5p hsa-miR-548b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SF3B2 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for SF3B2
    Predesigned siRNA for gene silencing in human, mouse, rat SF3B2
    Clone
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    OriGene ORF clones in mouse, rat for SF3B2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SF3B2 (NM_006842)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SF3B2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B2
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for SF3B2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SF3B2
      QuantiTect SYBR Green Assays in human, mouse, rat SF3B2
      QuantiFast Probe-based Assays in human, mouse, rat SF3B2

    Additional mRNA sequence: 

    AK290850.1 AK300016.1 BC000401.2 BC007610.1 BC014125.2 BC051237.1 BC053577.1 BX537771.1 
    U41371.1 

    Selected DOTS entries (see all 31):

    DT.99980629  DT.448681  DT.100059644  DT.100660663  DT.100660660  DT.95272329  DT.95310541  DT.95272343 
    DT.100660666  DT.102835748  DT.433578  DT.95272323  DT.86841098  DT.100660665  DT.95259573  DT.100803108 
    DT.100863040  DT.120715150  DT.91832863  DT.92391931  DT.95107061  DT.95180310  DT.95235736  DT.95272332 

    Selected AceView cDNA sequences (see all 854):

    BQ882957 BU618311 CA417860 U41371 BM993285 BM787595 BE891403 BQ070437 
    BU500428 BQ944912 BM564647 BM825401 BQ068595 BG940336 BQ679019 CD678819 
    CD244364 BU860388 BM844726 CF125790 BU165937 BU932073 BU539359 BQ650350 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SF3B2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a ·
    SP1:                                                              -                                               -     -                                       
    SP2:                                                              -                 -     -     -     -           -     -                                       
    SP3:                                                              -                                                                                             
    SP4:                                                              -                                                                                             
    SP5:                                                              -                                               -     -                                       

    ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for SF3B2

    Expression
    for SF3B2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SF3B2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTATTTT
    SF3B2 Expression
    About this image


    SF3B2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    SF3B2 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    SF3B2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406423
        Custom PCR Arrays for SF3B2
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    Orthologs
    for SF3B2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SF3B2 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sf3b21 , 5 splicing factor 3b, subunit 21, 5 89.67(n)1
    97.72(a)1    		   19 (4.29 cM)5
    3193221  NM_030109.21  NP_084385.21 
     52739235 
    lizard
    (Anolis carolinensis)    		 Reptilia SF3B26
    		 splicing factor 3b, subunit 2, 145kDa
    		 67(a)
    		 1 ↔ 1
    		 GL343832.1(8885-37047)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.66842 Xenopus laevis transcribed sequence with moderate similarity more 77.22(n)    BU901097.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb53c072 wufb53c07 78.87(n)   322210  CA471036.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG36051 , 3 mRNA splicing pre-mRNA splicing factor3
    CG36051    		 64(a)3
    63.55(n)1
    64.77(a)1    		   23C53
    335141  NM_134895.41  NP_608739.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea W03F9.103
    CELE_W03F9.101    		 CELE_W03F9.101 50(a)3
    57.79(n)1
    54.83(a)1    		   V(127982-129171)3
    1785421  NM_070740.41  NP_503141.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CUS1(YMR240C)4 Protein required for assembly of U2 snRNP into the more   --   13(751240-749930) 855281  NP_013967.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G216601 AT4G21660 56.47(n)
    53.52(a)    		   828253  NM_001203860.1  NP_001190789.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.265012 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.9(n)    AK069159.1 


    ENSEMBL Gene Tree for SF3B2 (if available)
    TreeFam Gene Tree for SF3B2 (if available)

    Paralogs
    for SF3B2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SF3B2 gene
    1 SIMAP similar gene for SF3B2 using alignment to 7 protein entries:     SF3B2_HUMAN (see all proteins):
    DKFZp781L0540

    SF3B2 for paralogs           About GeneDecksing



    Genomic Variants
    for SF3B2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SF3B2 (see all 393)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs5601051,2
    		C,F--65818832(-) AGAGGC/TAGAGA 1 -- us2k14Minor allele frequency- T:0.07NA WA 124
    rs1390187151,2
    		C--65818888(+) GTGGGA/GCCCCC 1 -- us2k10--------
    rs22413041,2
    		C,F,H--65819014(-) GCGTTC/TAAGAG 1 -- us2k16Minor allele frequency- T:0.11NS EA WA 646
    rs32172081,2
    		C--65819173(-) ATGTC-/GTC   
       TTCTC    CACTA     		1 -- us2k10--------
    rs754359571,2
    		F--65819193(+) GAGCCG/AGCCTG 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs729326821,2
    		--65819281(+) TCTCCC/GGGCTT 1 -- us2k10--------
    rs1419561391,2
    		--65819310(+) TTCATC/TCGGGC 1 -- us2k10--------
    rs358788591,2
    		C--65819380(+) AGCCTC/TCCGCT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs112996591,2
    		C--65819432(+) GGGAC-/TCCCTG 1 -- us2k10--------
    rs1463150151,2
    		--65819444(+) GAGCGG/TAAGCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SF3B2 (65818200 - 65836779 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SF3B2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897770CNV Loss21882294
    dgv1186n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    Disorders / Diseases
    for SF3B2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605591    OMIM disorders: --

    12 diseases for SF3B2:    
    About MalaCards
    leiomyoma    herpes simplex    bipolar disorder    tonsillitis
    hiv-1    multiple myeloma    myeloma    thyroiditis
    cerebritis    malaria    prostatitis    endotheliitis


    SF3B2 for disorders           About GeneDecksing


    Export disorders for SF3B2 gene to outside databases

    Publications
    for SF3B2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SF3B2 gene, integrated from 10 sources (see all 87):
    (articles sorted by number of sources associating them with SF3B2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A. (PubMed id 8566756)1, 2, 3 Gozani O.... Reed R. (Genes Dev. 1996)
    2. Human immunodeficiency virus type 1 Vpr induces G2 checkpoint activation by interacting with the splicing factor SAP145. (PubMed id 16923959)1, 2, 9 Terada Y. and Yasuda Y. (Mol. Cell. Biol. 2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (RNA 2004)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    6. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PubMed id 12234937)1, 2 Will C.L.... Luehrmann R. (EMBO J. 2002)
    7. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. (PubMed id 10882114)1, 2 Das R.... Reed R. (Mol. Cell 2000)
    8. The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. (PubMed id 7958871)1, 9 Champion-Arnaud P. and Reed R. (Genes Dev. 1994)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)

    External Searches for SF3B2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SF3B2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10992 HGNC: 10769 AceView: SF3B2 Ensembl:ENSG00000087365 euGenes: HUgn10992
    ECgene: SF3B2 Kegg: 10992 H-InvDB: SF3B2

    Other Databases showing SF3B2 gene

    (According to HUGE)
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    Specialized Databases showing SF3B2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SF3B2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SF3B2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for SF3B2 gene:
    Search GeneIP for patents involving SF3B2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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