SF3B2 Gene
protein-coding GIFtS: 56
GCID: GC11P065827
|
|
splicing factor 3b, subunit 2, 145kDa(Previous names: splicing factor 3b, subunit 2, 145kD )
| |
Aliases
for SF3B2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Splicing Factor 3b, Subunit 2, 145kDa1 2 | | SF3b1502 3 | | SAP1451 2 3 5 | | SAP 1452 3 | | Cus11 2 | | SF3B1452 5 | | SF3b11 2 | | Splicing Factor 3b, Subunit 2, 145kD1 | | SF3b1451 3 | | Pre-MRNA Splicing Factor SF3b 145 KDa Subunit2 | | Pre-MRNA-Splicing Factor SF3b 145 KDa Subunit2 3 | | Spliceosome Associated Protein 1452 | | Spliceosome-Associated Protein 1452 3 | | Splicing Factor 3B Subunit 22 |
Export aliases for SF3B2 gene to outside databasesPrevious GC identifers: GC11P068353 GC11P067501 GC11P066069 GC11P065594 GC11P065576 GC11P065825 GC11P062145 |
Summaries
for SF3B2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SF3B2:
This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicingfactor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor theU2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly withsubunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminusand a glutamate-rich stretch in the C-terminus. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SF3B2_HUMAN, Q13435Function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of thebranch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E'complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class ofnuclear pre-mRNA intron
Gene Wiki entry for SF3B2
|
Genomic Views
for SF3B2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SF3B2 gene promoter:
Max1 RFX1 NF-1/L NF-1 Elk-1 Pax-5 AP-1 ATF-2 MIF-1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for SF3B2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SF3B2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13SF3B2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P065827: view genomic region
(about GC identifiers)
Start:
|
65,818,200 bp from pter |
End:
|
65,836,779 bp from pter |
Size:
|
18,580 bases |
Orientation:
|
plus strand |
|
Proteins
for SF3B2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SF3B2_HUMAN, Q13435 (See
protein sequence)Recommended Name: Splicing factor 3B subunit 2 Size: 895 amino acids; 100228 Da
Subunit: Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-typespliceosome. Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155,SF3B2/SAP145/SF3B145, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125. SF3Bassociates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex(U2 snRNP). SF3B2 interacts directly with SF3B4. Interacts with HIV-1 Vpr
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAA97461.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAA97461.1; Type=Frameshift; Positions=28; Sequence=AAH53577.1; Type=Miscellaneous discrepancy;Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAG61831.1; Type=Erroneous initiation;Note=Translation N-terminally extended;
1 PDB 3D structure from  and Proteopedia  for SF3B2:2DO5 (3D)
Secondary accessions: A8K485 B4DT19 Q7L4T5 Q7Z627 Q969K1 Q96CM6 Q9BWD2Explore the universe of human proteins at neXtProt for SF3B2: NX_Q13435
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13435
SF3B2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006833.2
ENSEMBL proteins: ENSP00000432655 ENSP00000318861 ENSP00000435495 ENSP00000431908 ENSP00000431520 ENSP00000435765 ENSP00000434288 ENSP00000436757 Reactome Protein details: Q13435
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
SF3B2 for ontologies About GeneDecksing
SF3B2 Antibody Products:
Assay Products for SF3B2: |
Protein
Domains /
Families
for SF3B2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SF3B2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13435ProtoNet protein and cluster: Q13435 2 Blocks protein families: IPB003034 DNA-binding SAP IPB006568 PSP
UniProtKB/Swiss-Prot: SF3B2_HUMAN, Q13435Similarity: Contains 1 SAP domain |
Function
for SF3B2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SF3B2_HUMAN, Q13435Function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of thebranch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E'complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class ofnuclear pre-mRNA intron
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SF3B2 (NM_006842) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SF3B2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3B2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
SF3B2 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for SF3B2:
|
Pathways & Interactions
for SF3B2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | | | 2 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for SF3B2
5/6 
Reactome Pathways for SF3B2 (see all 6)
1 
Kegg Pathway (Kegg details for SF3B2):
SF3B2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SF3B2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/893 Interacting proteins for SF3B2 (Q134352, 3 ENSP000003188614) via UniProtKB, MINT, STRING, and/or I2D (see all 893)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
SF3B2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SF3B2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SF3B2
Search CenterWatch for drugs/clinical trials and news about SF3B2
|
Transcripts
for SF3B2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SF3B2 gene: NM_006842.2 Unigene Cluster for SF3B2: Splicing factor 3b, subunit 2, 145kDa Hs.406423 [show with all ESTs]Unigene Representative Sequence: NM_00684216 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000529577 ENST00000534307 ENST00000528302 ENST00000322535(uc001ogx.1 uc001ogy.1)
ENST00000524627 ENST00000533595 ENST00000531041 ENST00000531589 ENST00000530322
ENST00000524475 ENST00000533421 ENST00000526653 ENST00000525207 ENST00000529994
ENST00000530981 ENST00000534765
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SF3B2 (NM_006842) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SF3B2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B2 |
Additional cDNA sequence: AK290850.1 AK300016.1 BC000401.2 BC007610.1 BC014125.2 BC051237.1 BC053577.1 BX537771.1 U41371.1 24/31 DOTS entries (see all 31): DT.99980629 DT.448681 DT.100059644 DT.100660663 DT.100660660 DT.95272329 DT.95310541 DT.95272343 DT.100660666 DT.102835748 DT.433578 DT.95272323 DT.86841098 DT.100660665 DT.95259573 DT.100803108 DT.100863040 DT.120715150 DT.91832863 DT.92391931 DT.95107061 DT.95180310 DT.95235736 DT.95272332 24/854 AceView cDNA sequences (see all 854): BM552774 AI299519 CD678819 BG940336 BQ944912 BM464626 BM549450 CB149641 BU535540 BQ227209 BE881494 CA307597 BF965868 BM781515 BM712981 BM809957 BM456112 CF125790 BU857145 CA425253 BM787595 BQ065980 AI133199 BU521492
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SF3B2 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 | ^ | 12 | ^ | 13a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | |
| ExUns: | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SF3B2
|
Expression
for SF3B2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SF3B2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTTATTTT
About this image
See SF3B2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SF3B2
SOURCE GeneReport for Unigene cluster: Hs.406423
SABiosciences Custom PCR Arrays for SF3B2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SF3B2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SF3B2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SF3B2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SF3B2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3B2 |
Orthologs
for SF3B2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SF3B2 gene from 8/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Sf3b21 , 5 |
splicing factor 3b, subunit 21, 5 |
89.67(n)1
97.72(a)1 |
|
19 (4.29 cM)5
3193221 NM_030109.21 NP_084385.21
52739235 |
lizard
(Anolis carolinensis) |
Reptilia |
SF3B26 |
-- |
67(a) |
1 ↔ 1 |
GL343832.1(8885-37047) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.66842 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.22(n) |
|
BU901097.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb53c072 |
wufb53c07 |
78.87(n) |
|
322210 CA471036.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG36051 , 3 |
mRNA splicing pre-mRNA splicing factor3
CG36051 |
64(a)3
62.63(n)1
62.69(a)1 |
|
23C53
335141 NM_134895.31 NP_608739.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
W03F9.103
CELE_W03F9.101 |
Protein W03F9.101 |
50(a)3
57.69(n)1
54.55(a)1 |
|
V(127982-129171)3
1785421 NM_070740.31 NP_503141.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G216601 |
splicing factor 3B subunit 2 |
54.36(n)
50.73(a) |
|
828253 NM_118286.3 NP_193897.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.265012 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
71.9(n) |
|
AK069159.1 |
ENSEMBL Gene Tree for SF3B2 (if available)
TreeFam Gene Tree for SF3B2 (if available) |
Paralogs
for SF3B2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SF3B2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SF3B2 (65818200 - 65836779 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SF3B2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SF3B2 |
|
Disorders
/ Diseases
for SF3B2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SF3B2 for disorders About GeneDecksing
OMIM gene information: 605591
OMIM disorders: --
4  diseases for SF3B2: About MalaCardsherpes simplex plague immunodeficiency malaria
Export disorders for SF3B2 gene to outside databases
|
Publications
for SF3B2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SF3B2 gene, integrated from 9 sources (see all 72):
(articles sorted by number of sources associating them with SF3B2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A. (PubMed id 8566756)1, 2, 3 Gozani O.... Reed R. (1996)
- Human immunodeficiency virus type 1 Vpr induces G2 checkpoint activation by interacting with the splicing factor SAP145. (PubMed id 16923959)1, 2, 9 Terada Y. and Yasuda Y. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (2004)
- Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
- Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PubMed id 12234937)1, 2 Will C.L....Luhrmann R. (2002)
- Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. (PubMed id 10882114)1, 2 Das R.... Reed R. (2000)
- The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. (PubMed id 7958871)1, 9 Champion-Arnaud P. and Reed R. (1994)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry. (PubMed id 22415777)1 Orr S.J....Thomas N.S. (2012)
|
External Searches for SF3B2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing SF3B2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SF3B2 gene
(According to HUGE)
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Specialized Databases showing SF3B2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for SF3B2 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for SF3B2 gene:
Search GeneIP for patents involving SF3B2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SF3B2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SF3B2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SF3B2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SF3B2 | | | OriGene Protein Over-expression Lysate for SF3B2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for SF3B2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SF3B2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SF3B2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SF3B2 | | OriGene Custom Protein Services for SF3B2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SF3B2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SF3B2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SF3B2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SF3B2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SF3B2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SF3B2 |
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| | | | Search Tocris compounds for SF3B2 |
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 | | | SF3B2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3B2 |
|  |  |  | | | | Search ThermoFisher Antibodies for SF3B2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B2 |
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