Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SF3B2 Gene

protein-coding GIFtS: 58
GCID: GC11P065827

Splicing Factor 3b, Subunit 2, 145kDa

(Previous names: splicing factor 3b, subunit 2, 145kD)

2 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Splicing Factor 3b, Subunit 2, 145kDa¹ ²		Splicing Factor 3b, Subunit 2, 145kD¹
SAP145² ³ ⁵		Cus1²
Pre-MRNA-Splicing Factor SF3b 145 KDa Subunit² ³		SF3b1²
Spliceosome-Associated Protein 145² ³		Pre-MRNA Splicing Factor SF3b 145 KDa Subunit²
SF3b150² ³		Spliceosome Associated Protein 145²
SAP 145² ³		Splicing Factor 3B Subunit 2²
SF3B145² ⁵		SF3b145³

External Ids:	HGNC: 10769¹	Entrez Gene: 10992²	Ensembl: ENSG00000087365⁷	OMIM: 605591⁵	UniProtKB: Q13435³

Export aliases for SF3B2 gene to outside databases

Previous GC identifers: GC11P068353 GC11P067501 GC11P066069 GC11P065594 GC11P065576 GC11P065825 GC11P062145

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SF3B2 Gene:

This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing

factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor

3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the

U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2

associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with

subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus

and a glutamate-rich stretch in the C-terminus. (provided by RefSeq, Jul 2008)

GeneCards Summary for SF3B2 Gene:

SF3B2 (splicing factor 3b, subunit 2, 145kDa) is a protein-coding gene. Diseases associated with SF3B2 include leiomyoma, and herpes simplex, and among its related super-pathways are mRNA Processing and Generic Transcription Pathway. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot: SF3B2_HUMAN, Q13435

Function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2

snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the

branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E'

complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of

nuclear pre-mRNA intron

Gene Wiki entry for SF3B2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NT_167190.1 NC_018922.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SF3B2 gene promoter:
Max1 RFX1 NF-1/L NF-1 Elk-1 Pax-5 AP-1 ATF-2 MIF-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SF3B2 promoter sequence

Search SABiosciences Chromatin IP Primers for SF3B2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SF3B2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13

SF3B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SF3B2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P065827: view genomic region (about GC identifiers)

Start:	65,818,200 bp from pter	End:	65,836,779 bp from pter
Size:	18,580 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SF3B2_HUMAN, Q13435 (See protein sequence)

Recommended Name: Splicing factor 3B subunit 2

Size: 895 amino acids; 100228 Da

Subunit: Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type

spliceosome. Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155,

SF3B2/SAP145/SF3B145, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125. SF3B

associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex

(U2 snRNP). SF3B2 interacts directly with SF3B4. Interacts with HIV-1 Vpr

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=AAA97461.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAA97461.1; Type=Frameshift; Positions=28; Sequence=AAH53577.1; Type=Miscellaneous discrepancy;

Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAG61831.1; Type=Erroneous initiation;

Note=Translation N-terminally extended;

1 PDB 3D structure from and Proteopedia for SF3B2:

2DO5 (3D)

Secondary accessions: A8K485 B4DT19 Q7L4T5 Q7Z627 Q969K1 Q96CM6 Q9BWD2

Explore the universe of human proteins at neXtProt for SF3B2: NX_Q13435

Explore proteomics data for SF3B2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q13435

SF3B2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_006833.2

ENSEMBL proteins:

ENSP00000432655 ENSP00000318861 ENSP00000435495 ENSP00000431908 ENSP00000431520

ENSP00000435765 ENSP00000436757

Reactome Protein details: Q13435
Human Recombinant Protein Products for SF3B2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for SF3B2 OriGene Protein Over-expression Lysate for SF3B2 OriGene MassSpec for SF3B2 OriGene Custom Protein Services for SF3B2
	GenScript Custom Purified and Recombinant Proteins Services for SF3B2
	Novus Biologicals SF3B2 Proteins Novus Biologicals SF3B2 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for SF3B2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005681	spliceosomal complex	IDA	9731529
GO:0005689	U12-type spliceosomal complex	IDA	15146077
GO:0005730	NOT nucleolus	IDA	--

SF3B2 for ontologies About GeneDecksing

SF3B2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SF3B2
	GenScript Custom Superior Antibodies Services for SF3B2
	Novus Biologicals SF3B2 Antibodies
	Abcam antibodies for SF3B2
	Cloud-Clone Corp. Antibodies for SF3B2
	Search ThermoFisher Antibodies for SF3B2
	LSBio Antibodies in human, mouse, rat for SF3B2

Assay Products for SF3B2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SF3B2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SF3B2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SF3B2 Cloud-Clone Corp. CLIAs for SF3B2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro protein domains:

IPR006568 PSP

IPR007180 DUF382

IPR003034 SAP_dom

Graphical View of Domain Structure for InterPro Entry Q13435

ProtoNet protein and cluster: Q13435

2 Blocks protein domains:

IPB003034 DNA-binding SAP

IPB006568 PSP

UniProtKB/Swiss-Prot: SF3B2_HUMAN, Q13435

Similarity: Contains 1 SAP domain

SF3B2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SF3B2_HUMAN, Q13435

Function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2

snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the

branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E'

complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of

nuclear pre-mRNA intron

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0005515	protein binding	IPI	16189514

SF3B2 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for SF3B2:

Decreased influenza A virus in

Decreased viability

Decreased viability of wild-ty

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for SF3B2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SF3B2

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SF3B2
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate SF3B2:
		hsa-miR-4261 hsa-miR-520d-5p hsa-miR-130b* hsa-miR-524-5p hsa-miR-548b-3p
		SwitchGear 3'UTR luciferase reporter plasmid: SF3B2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SF3B2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SF3B2
		Sirion Biotech Custom design and validation of potent shRNA sequences against SF3B2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SF3B2
			Sirion Biotech Customized adenovirus for overexpression of SF3B2 Customized adenovirus for potent knockdown of SF3B2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for SF3B2 (see all 6) OriGene ORF clones in mouse, rat for SF3B2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SF3B2 (NM_006842)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SF3B2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SF3B2
		Search LifeMap BioReagents cell lines for SF3B2
		Sirion Biotech Customized stable knockdown cell line services for SF3B2 Customized inducible knockdown cell line services for SF3B2 Customized stable overexpressing cell line services for SF3B2 Customized inducible overexpressing cell line services for SF3B2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3B2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SF3B2 About

See pathways by source

SuperPath

Contained pathways About

mRNA Splicing - Major Pathway

Processing of Capped Intron-Containing Pre-mRNA	0.85	mRNA processing	0.46
mRNA Processing	0.85	mRNA Splicing - Minor Pathway	0.40
mRNA Splicing - Major Pathway	0.82	Spliceosome	0.31
mRNA Splicing	0.82

Generic Transcription Pathway

Gene Expression

0.47

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for SF3B2

mRNA processing

5/6 Reactome Pathways for SF3B2 (see all 6)

	mRNA Splicing - Major Pathway
	mRNA Splicing
	Gene Expression
	mRNA Processing
	mRNA Splicing - Minor Pathway

1 Kegg Pathway (Kegg details for SF3B2):

Spliceosome

SF3B2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SF3B2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/939 Interacting proteins for SF3B2 (Q13435^{2, 3} ENSP00000318861⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 939)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SF3B1	O75533²^,³, ENSP00000335321⁴	MINT-7945693 MINT-6488590 MINT-6489355 MINT-7947479 MINT-8207078 I2D: score=1 STRING: ENSP00000335321
SF3B4	Q15427²^,³, ENSP00000271628⁴	MINT-7945693 MINT-8332328 MINT-8333515 I2D: score=5 STRING: ENSP00000271628
SF3A2	Q15428²^,³, ENSP00000221494⁴	MINT-5205476 MINT-7947479 I2D: score=2 STRING: ENSP00000221494
SRRM1	Q8IYB3²^,³, ENSP00000326261⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000326261
EPS8L2	Q9H6S3²^,³	MINT-7945693 MINT-7947479 I2D: score=4

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0006397	mRNA processing	TAS	8566756
GO:0008380	RNA splicing	TAS	--
GO:0010467	gene expression	TAS	--
GO:0019048	modulation by virus of host morphology or physiology	IEA	--

SF3B2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SF3B2

Search CenterWatch for drugs/clinical trials and news about SF3B2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SF3B2 gene:

NM_006842.2

Unigene Cluster for SF3B2:

Splicing factor 3b, subunit 2, 145kDa

Hs.406423 [show with all ESTs]

Unigene Representative Sequence: NM_006842

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000529577 ENST00000534307 ENST00000528302 ENST00000322535(uc001ogx.1 uc001ogy.1)

ENST00000524627 ENST00000533595 ENST00000531041 ENST00000531589 ENST00000530322

ENST00000524475 ENST00000533421 ENST00000526653 ENST00000525207 ENST00000529994

ENST00000530981 ENST00000534765

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SF3B2
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate SF3B2:
		hsa-miR-4261 hsa-miR-520d-5p hsa-miR-130b* hsa-miR-524-5p hsa-miR-548b-3p
		SwitchGear 3'UTR luciferase reporter plasmid: SF3B2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SF3B2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SF3B2
		Sirion Biotech Custom design and validation of potent shRNA sequences against SF3B2

Clone Products:		OriGene clones in human, mouse for SF3B2 (see all 6) OriGene ORF clones in mouse, rat for SF3B2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SF3B2 (NM_006842)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SF3B2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SF3B2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SF3B2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SF3B2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SF3B2

Additional mRNA sequence:

AK290850.1 AK300016.1 BC000401.2 BC007610.1 BC014125.2 BC051237.1 BC053577.1 BX537771.1

U41371.1

24/31 DOTS entries (see all 31):

DT.99980629 DT.448681 DT.100059644 DT.100660663 DT.100660660 DT.95272329 DT.95310541 DT.95272343

DT.100660666 DT.102835748 DT.433578 DT.95272323 DT.86841098 DT.100660665 DT.95259573 DT.100803108

DT.100863040 DT.120715150 DT.91832863 DT.92391931 DT.95107061 DT.95180310 DT.95235736 DT.95272332

24/854 AceView cDNA sequences (see all 854):

BU682565 BI335917 BE881494 AW027815 BE894339 AA543090 BP429624 BM853129

BQ684749 BU157882 BM784265 BE395989 BE272502 BQ652198 BQ070055 BF684335

CB153050 AI589455 BU521492 BM844767 BE740982 BM541616 BE791803 CB155961

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SF3B2 (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	·	10d	^	11	^	12	^	13a	·
SP1:																					-																-		-
SP2:																					-						-		-		-		-				-		-
SP3:																					-
SP4:																					-
SP5:																					-																-		-

ExUns:	13b	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^	22a	·	22b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SF3B2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SF3B2 expression in normal human tissues (normalized intensities) SF3B2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTCTTATTTT

About this image

SF3B2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/31 selected tissues (see all 31) fully expand


Reproductive System (Reproductive System) fully expand to see all 8 entries
vagina ; squamous epithelial cells

Skin (Integumentary System) fully expand to see all 5 entries
skin ; keratinocytes

Testis (Reproductive System) fully expand to see all 4 entries
Leydig Cells Testis Interstitium
seminal vesicle ; glandular cells

Brain (Nervous System) fully expand to see all 4 entries
Hippocampus

Tonsil
tonsil ; squamous epithelial cells

See SF3B2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SF3B2

SOURCE GeneReport for Unigene cluster: Hs.406423

SABiosciences Custom PCR Arrays for SF3B2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SF3B2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SF3B2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SF3B2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SF3B2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3B2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3B2 gene from 9/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sf3b2^{1 , 5}	splicing factor 3b, subunit 2^{1, 5}	89.67(n)¹ 97.72(a)¹		19 (4.29 cM)⁵ 319322¹ NM_030109.2¹ NP_084385.2¹ 5273923⁵
lizard (Anolis carolinensis)	Reptilia	SF3B2⁶	Uncharacterized protein	67(a)	1 ↔ 1	GL343832.1(8885-37047)
African clawed frog (Xenopus laevis)	Amphibia	Xl.6684²	Xenopus laevis transcribed sequence with moderate similarity more	77.22(n)		BU901097.1
zebrafish (Danio rerio)	Actinopterygii	wufb53c07²	wufb53c07	78.87(n)		322210 CA471036.1
fruit fly (Drosophila melanogaster)	Insecta	CG3605^{1 , 3}	mRNA splicing pre-mRNA splicing factor³ CG3605¹	64(a)³ 62.63(n)¹ 62.69(a)¹		23C5³ 33514¹ NM_134895.3¹ NP_608739.1¹
worm (Caenorhabditis elegans)	Secernentea	W03F9.10³ CELE_W03F9.10¹	Protein W03F9.10¹	50(a)³ 57.69(n)¹ 54.55(a)¹		V(127982-129171)³ 178542¹ NM_070740.3¹ NP_503141.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CUS1(YMR240C)⁴	Protein required for assembly of U2 snRNP into the more	--		13(751240-749930) 855281 NP_013967.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G21660¹	splicing factor 3B subunit 2	54.36(n) 50.73(a)		828253 NM_118286.3 NP_193897.2
rice (Oryza sativa)	Liliopsida	Os.26501²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	71.9(n)		AK069159.1

ENSEMBL Gene Tree for SF3B2 (if available)
TreeFam Gene Tree for SF3B2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SF3B2 gene

1 SIMAP similar gene for SF3B2 using alignment to 7 protein entries: SF3B2_HUMAN (see all proteins):

DKFZp781L0540

SF3B2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs560105^1,2	C,F	--	65818832(-)	`AGAGGC/TAGAGA`	1	--	us2k¹		4		NA WA	124
rs139018715^1,2	C	--	65818888(+)	`GTGGGA/GCCCCC`	1	--	us2k¹		0	--	--	--	--
rs2241304^1,2	C,F,H	--	65819014(-)	`GCGTTC/TAAGAG`	1	--	us2k¹		6		NS EA WA	646
rs3217208^1,2	C	--	65819173(-)	`ATGTC-/GTC TTCTCCACTA`	1	--	us2k¹		0	--	--	--	--
rs75435957^1,2	F	--	65819193(+)	`GAGCCG/AGCCTG`	1	--	us2k¹		1		EA	120
rs72932682^1,2		--	65819281(+)	`TCTCCC/GGGCTT`	1	--	us2k¹		0	--	--	--	--
rs141956139^1,2		--	65819310(+)	`TTCATC/TCGGGC`	1	--	us2k¹		0	--	--	--	--
rs35878859^1,2	C	--	65819380(+)	`AGCCTC/TCCGCT`	1	--	us2k¹		1		NA	2
rs11299659^1,2	C	--	65819432(+)	`GGGAC-/TCCCTG`	1	--	us2k¹		0	--	--	--	--
rs146315015^1,2		--	65819444(+)	`GAGCGG/TAAGCG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SF3B2 (65818200 - 65836779 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for SF3B2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv897770	CNV	Loss	21882294
dgv1186n71	CNV	Loss	21882294

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SF3B2

DNA2.0 Custom Variant and Variant Library Synthesis for SF3B2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SF3B2 for disorders           About GeneDecksing

OMIM gene information: 605591    OMIM disorders: --

2 diseases for SF3B2:    About MalaCards

leiomyoma herpes simplex

Export disorders for SF3B2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SF3B2 gene, integrated from 9 sources (see all 84):
(articles sorted by number of sources associating them with SF3B2)

Utopia: connect your pdf to the dynamic
world of online information

Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A. (PubMed id 8566756)^{1, 2, 3} Gozani O.... Reed R. (1996)
Human immunodeficiency virus type 1 Vpr induces G2 checkpoint activation by interacting with the splicing factor SAP145. (PubMed id 16923959)^{1, 2, 9} Terada Y. and Yasuda Y. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)^{1, 2} Will C.L.... Luehrmann R. (2004)
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)^{1, 2} Jurica M.S.... Moore M.J. (2002)
Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PubMed id 12234937)^{1, 2} Will C.L....Luhrmann R. (2002)
Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. (PubMed id 10882114)^{1, 2} Das R.... Reed R. (2000)
The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. (PubMed id 7958871)^{1, 9} Champion-Arnaud P. and Reed R. (1994)
A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)¹ Weimann M.... Stelzl U. (2013)
Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)¹ Varjosalo M....Superti-Furga G. (2013)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10992	HGNC: 10769	AceView: SF3B2	Ensembl:ENSG00000087365	euGenes: HUgn10992
ECgene: SF3B2	Kegg: 10992	H-InvDB: SF3B2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SF3B2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SF3B2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SF3B2 gene:
Search GeneIP for patents involving SF3B2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for SF3B2
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for SF3B2
	OriGene MassSpec something-or-other for SF3B2		OriGene clones in human, mouse for SF3B2
	OriGene qSTAR qPCR primer pairs in human, mouse for SF3B2		OriGene Purified Protein for SF3B2
	OriGene ORF clones in mouse, rat for SF3B2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SF3B2		OriGene Custom Protein Services for SF3B2

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SF3B2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SF3B2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SF3B2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SF3B2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SF3B2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SF3B2

	GenScript Custom Purified and Recombinant Proteins Services for SF3B2		GenScript cDNA clones with any tag delivered in your preferred vector for SF3B2
	GenScript Custom Assay Services for SF3B2		GenScript Custom Superior Antibodies Services for SF3B2
	GenScript Custom overexpressing Cell Line Services for SF3B2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SF3B2 promoter
	Search Chromatin IP Primers for SF3B2
	RT² qPCR Primer Assay in human, mouse, rat SF3B2
	GNC Network for SF3B2
	SABiosciences Custom PCR Arrays for SF3B2

Search Tocris compounds for SF3B2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SF3B2 antibodies
	SF3B2 proteins
	SF3B2 lysates

	Antibodies for SF3B2
	See all of Abcam's Antibodies, Kits and Proteins for SF3B2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for SF3B2
	Antibodies for SF3B2
	ELISAs for SF3B2
	CLIAs for SF3B2

Search LifeMap BioReagents cell lines for SF3B2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3B2

	SwitchGear 3'UTR luciferase reporter plasmids for SF3B2
	SwitchGear Promoter luciferase reporter plasmids for SF3B2

Search ThermoFisher Antibodies for SF3B2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SF3B2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for SF3B2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SF3B2

Customized:

	stable knockdown cell line services for SF3B2
	inducible knockdown cell line services for SF3B2
	design and validation of potent shRNA sequences against SF3B2
	adenovirus for potent knockdown of SF3B2
	stable overexpressing cell line services for SF3B2
	inducible overexpressing cell line services for SF3B2
	adenovirus for overexpression of SF3B2

LSBio Antibodies in human, mouse, rat for SF3B2

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SF3B2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

SF3B2 Gene

Splicing Factor 3b, Subunit 2, 145kDa

Aliases
for SF3B2 gene

Summaries
for SF3B2 gene

Genomic Views
for SF3B2 gene

Proteins
for SF3B2 gene

Protein Domains /
Families
for SF3B2 gene

Function
for SF3B2 gene

Pathways & Interactions
for SF3B2 gene

Drugs & Compounds
for SF3B2 gene

Transcripts
for SF3B2 gene

Expression
for SF3B2 gene

Orthologs
for SF3B2 gene

Paralogs
for SF3B2 gene

Genomic Variants
for SF3B2 gene

Disorders / Diseases
for SF3B2 gene

Publications
for SF3B2 gene

External Searches for SF3B2 gene

Genome Databases showing SF3B2 gene

Other Databases showing SF3B2 gene

Specialized Databases showing SF3B2 gene

Intellectual Property
for SF3B2 gene

Products
for SF3B2 gene

View Random Gene

Advanced Search

Export list of displayed genes

SF3B2 Gene

Splicing Factor 3b, Subunit 2, 145kDa

Aliasesfor SF3B2 gene

Summariesfor SF3B2 gene

Genomic Viewsfor SF3B2 gene

Proteinsfor SF3B2 gene

Protein Domains /Familiesfor SF3B2 gene

Functionfor SF3B2 gene

Pathways & Interactionsfor SF3B2 gene

Drugs & Compoundsfor SF3B2 gene

Transcriptsfor SF3B2 gene

Expression for SF3B2 gene

Orthologsfor SF3B2 gene

Paralogsfor SF3B2 gene

Genomic Variantsfor SF3B2 gene

Disorders / Diseasesfor SF3B2 gene

Publicationsfor SF3B2 gene

External Searches for SF3B2 gene

Genome Databases showing SF3B2 gene

Other Databases showing SF3B2 gene

Specialized Databases showing SF3B2 gene

Intellectual Propertyfor SF3B2 gene

Productsfor SF3B2 gene

View Random Gene

Aliases
for SF3B2 gene

Summaries
for SF3B2 gene

Genomic Views
for SF3B2 gene

Proteins
for SF3B2 gene

Protein Domains /
Families
for SF3B2 gene

Function
for SF3B2 gene

Pathways & Interactions
for SF3B2 gene

Drugs & Compounds
for SF3B2 gene

Transcripts
for SF3B2 gene

Expression
for SF3B2 gene

Orthologs
for SF3B2 gene

Paralogs
for SF3B2 gene

Genomic Variants
for SF3B2 gene

Disorders / Diseases
for SF3B2 gene

Publications
for SF3B2 gene

Intellectual Property
for SF3B2 gene

Products
for SF3B2 gene