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Aliases for SF3A3 Gene

Aliases for SF3A3 Gene

  • Splicing Factor 3a Subunit 3 2 3 5
  • Splicing Factor 3a, Subunit 3, 60kDa 2 3
  • Splicing Factor 3a, Subunit 3, 60kD 2 3
  • Spliceosome-Associated Protein 61 3 4
  • SAP 61 3 4
  • SF3a60 3 4
  • SAP61 3 4
  • Pre-MRNA Splicing Factor SF3a (60kD) 3
  • Spliceosome Associated Protein 61 3
  • PRPF9 3
  • PRP9 3

External Ids for SF3A3 Gene

Previous GeneCards Identifiers for SF3A3 Gene

  • GC01P038261
  • GC01M037458
  • GC01M037835
  • GC01M037826
  • GC01M038091
  • GC01M038195
  • GC01M038422
  • GC01M036540

Summaries for SF3A3 Gene

Entrez Gene Summary for SF3A3 Gene

  • This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for SF3A3 Gene

SF3A3 (Splicing Factor 3a Subunit 3) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding. An important paralog of this gene is SDE2.

UniProtKB/Swiss-Prot for SF3A3 Gene

  • Subunit of the splicing factor SF3A required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex.

Gene Wiki entry for SF3A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SF3A3 Gene

Genomics for SF3A3 Gene

Regulatory Elements for SF3A3 Gene

Promoters for SF3A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SF3A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SF3A3 Gene

Chromosome:
1
Start:
37,956,975 bp from pter
End:
37,990,921 bp from pter
Size:
33,947 bases
Orientation:
Minus strand

Genomic View for SF3A3 Gene

Genes around SF3A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SF3A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SF3A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SF3A3 Gene

Proteins for SF3A3 Gene

  • Protein details for SF3A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12874-SF3A3_HUMAN
    Recommended name:
    Splicing factor 3A subunit 3
    Protein Accession:
    Q12874
    Secondary Accessions:
    • D3DPT5
    • Q15460
    • Q5VT87

    Protein attributes for SF3A3 Gene

    Size:
    501 amino acids
    Molecular mass:
    58849 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interacts with SF3A1, through its N-terminal region.

    Three dimensional structures from OCA and Proteopedia for SF3A3 Gene

neXtProt entry for SF3A3 Gene

Proteomics data for SF3A3 Gene at MOPED

Post-translational modifications for SF3A3 Gene

  • Ubiquitination at Lys 201 and Lys 390
  • Modification sites at PhosphoSitePlus

Other Protein References for SF3A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SF3A3 Gene

Domains & Families for SF3A3 Gene

Protein Domains for SF3A3 Gene

Suggested Antigen Peptide Sequences for SF3A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12874

UniProtKB/Swiss-Prot:

SF3A3_HUMAN :
  • Belongs to the SF3A3 family.
  • Contains 1 matrin-type zinc finger.
Family:
  • Belongs to the SF3A3 family.
Similarity:
  • Contains 1 matrin-type zinc finger.
genes like me logo Genes that share domains with SF3A3: view

No data available for Gene Families for SF3A3 Gene

Function for SF3A3 Gene

Molecular function for SF3A3 Gene

UniProtKB/Swiss-Prot Function:
Subunit of the splicing factor SF3A required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex.

Gene Ontology (GO) - Molecular Function for SF3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SF3A3: view
genes like me logo Genes that share phenotypes with SF3A3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SF3A3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SF3A3 Gene

Localization for SF3A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SF3A3 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SF3A3 Gene COMPARTMENTS Subcellular localization image for SF3A3 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SF3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with SF3A3: view

Pathways & Interactions for SF3A3 Gene

genes like me logo Genes that share pathways with SF3A3: view

Pathways by source for SF3A3 Gene

Gene Ontology (GO) - Biological Process for SF3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions TAS 7816610
genes like me logo Genes that share ontologies with SF3A3: view

No data available for SIGNOR curated interactions for SF3A3 Gene

Drugs & Compounds for SF3A3 Gene

No Compound Related Data Available

Transcripts for SF3A3 Gene

Unigene Clusters for SF3A3 Gene

Splicing factor 3a, subunit 3, 60kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SF3A3 Gene

No ASD Table

Relevant External Links for SF3A3 Gene

GeneLoc Exon Structure for
SF3A3
ECgene alternative splicing isoforms for
SF3A3

Expression for SF3A3 Gene

mRNA expression in normal human tissues for SF3A3 Gene

Protein differential expression in normal tissues from HIPED for SF3A3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9) and NK cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SF3A3 Gene



SOURCE GeneReport for Unigene cluster for SF3A3 Gene Hs.77897

mRNA Expression by UniProt/SwissProt for SF3A3 Gene

Q12874-SF3A3_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with SF3A3: view

Protein tissue co-expression partners for SF3A3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SF3A3 Gene

Orthologs for SF3A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SF3A3 35
  • 93.21 (n)
  • 99.6 (a)
SF3A3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SF3A3 35
  • 92.02 (n)
  • 99.8 (a)
-- 36
  • 100 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sf3a3 35
  • 91.28 (n)
  • 99.2 (a)
Sf3a3 16
Sf3a3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SF3A3 35
  • 99.93 (n)
  • 100 (a)
SF3A3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sf3a3 35
  • 91.88 (n)
  • 99.2 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SF3A3 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves SF3A3 35
  • 82.57 (n)
  • 97.01 (a)
SF3A3 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SF3A3 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sf3a3 35
  • 80.57 (n)
  • 93.01 (a)
Str.78 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.27314 35
zebrafish
(Danio rerio)
Actinopterygii sf3a3 35
  • 79.77 (n)
  • 91.02 (a)
sf3a3 36
  • 91 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta noi 37
  • 63 (a)
noi 35
  • 62.05 (n)
  • 65.46 (a)
noi 36
  • 65 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T13H5.4 37
  • 52 (a)
T13H5.4 35
  • 55.96 (n)
  • 52.61 (a)
T13H5.4 36
  • 52 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP9 36
  • 22 (a)
OneToMany
PRP9 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ATO 35
  • 52.12 (n)
  • 46.11 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3335 35
rice
(Oryza sativa)
Liliopsida Os.11669 35
Os03g0717600 35
  • 52 (n)
  • 45.42 (a)
corn
(Zea mays)
Liliopsida Zm.6441 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1167 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToOne
Species with no ortholog for SF3A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SF3A3 Gene

ENSEMBL:
Gene Tree for SF3A3 (if available)
TreeFam:
Gene Tree for SF3A3 (if available)

Paralogs for SF3A3 Gene

Paralogs for SF3A3 Gene

Pseudogenes.org Pseudogenes for SF3A3 Gene

genes like me logo Genes that share paralogs with SF3A3: view

Variants for SF3A3 Gene

Sequence variations from dbSNP and Humsavar for SF3A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9293 -- 37,958,181(-) GTGTT(C/G)AGGGA utr-variant-3-prime
rs9686 -- 37,957,278(-) ACTGG(A/T)GGGTC utr-variant-3-prime
rs1050257 -- 37,957,916(-) CTTAA(C/T)GCCTC utr-variant-3-prime
rs1802611 -- 37,969,374(-) CCAAA(G/T)CCTTC reference, missense
rs1802612 -- 37,958,069(-) GTCTA(G/T)CATGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SF3A3 Gene

Variant ID Type Subtype PubMed ID
nsv870730 CNV Gain 21882294
nsv822331 CNV Loss 20364138
esv267758 CNV Insertion 20981092

Variation tolerance for SF3A3 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SF3A3 Gene

HapMap Linkage Disequilibrium report
SF3A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SF3A3 Gene

Disorders for SF3A3 Gene

Relevant External Links for SF3A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SF3A3

No disorders were found for SF3A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SF3A3 Gene

Publications for SF3A3 Gene

  1. Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114. (PMID: 8022796) Chiara M.D. … Reed R. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 67
  2. Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. (PMID: 11533230) Nesic D. … KrAomer A. (Mol. Cell. Biol. 2001) 3 23
  3. Splicing factor SF3a60 is the mammalian homologue of PRP9 of S.cerevisiae: the conserved zinc finger-like motif is functionally exchangeable in vivo. (PMID: 7816610) Kraemer A. … Bilbe G. (Nucleic Acids Res. 1994) 2 3
  4. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  5. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3

Products for SF3A3 Gene

Sources for SF3A3 Gene

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