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SF3A3 Gene

protein-coding   GIFtS: 57
GCID: GC01M038422

Splicing Factor 3a, Subunit 3, 60kDa

(Previous names: splicing factor 3a, subunit 3, 60kD)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Splicing Factor 3a, Subunit 3, 60kDa1 2     Splicing Factor 3a, Subunit 3, 60kD1
SAP612 3 5     PRPF92
Spliceosome-Associated Protein 612 3     Pre-MRNA Splicing Factor SF3a (60kD)2
SF3a602 3     Spliceosome Associated Protein 612
SAP 612 3     Splicing Factor 3A Subunit 32
PRP92 5     SF3A605

External Ids:    HGNC: 107671   Entrez Gene: 109462   Ensembl: ENSG000001834317   OMIM: 6055965   UniProtKB: Q128743   

Export aliases for SF3A3 gene to outside databases

Previous GC identifers: GC01P038261 GC01M037458 GC01M037886 GC01M037835 GC01M037826 GC01M038091 GC01M038195 GC01M036540


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SF3A3 Gene:
This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer
includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S
particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the
zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on
chromosome 20. (provided by RefSeq, Jul 2008)

GeneCards Summary for SF3A3 Gene:
SF3A3 (splicing factor 3a, subunit 3, 60kDa) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SDE2.

UniProtKB/Swiss-Prot: SF3A3_HUMAN, Q12874
Function: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2
snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream
of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of
the 'E' complex

Gene Wiki entry for SF3A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SF3A3 gene promoter:
         E2F-4   Bach1   E2F-3a   STAT1   E2F-5   E2F-2   C/EBPalpha   E47   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSF3A3 promoter sequence
   Search Chromatin IP Primers for SF3A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SF3A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

SF3A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SF3A3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M038422:  view genomic region     (about GC identifiers)

Start:
38,422,647 bp from pter      End:
38,456,593 bp from pter
Size:
33,947 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SF3A3_HUMAN, Q12874 (See protein sequence)
Recommended Name: Splicing factor 3A subunit 3  
Size: 501 amino acids; 58849 Da
Subunit: Identified in the spliceosome C complex. Component of splicing factor SF3A which is composed of three
subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA
unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interacts with SF3A1, through its
N-terminal region
1 PDB 3D structure from and Proteopedia for SF3A3:
2DT7 (3D)    
Secondary accessions: D3DPT5 Q15460 Q5VT87

Explore the universe of human proteins at neXtProt for SF3A3: NX_Q12874

Explore proteomics data for SF3A3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys201, Lys390
  • Modification sites at PhosphoSitePlus

  • See SF3A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006793.1  
    ENSEMBL proteins: 
     ENSP00000362110   ENSP00000392027  
    Reactome Protein details: Q12874

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR000690 Znf_C2H2_matrin
     IPR021966 SF3a60_bindingd
     IPR024598 DUF3449

    Graphical View of Domain Structure for InterPro Entry Q12874

    ProtoNet protein and cluster: Q12874

    UniProtKB/Swiss-Prot: SF3A3_HUMAN, Q12874
    Similarity: Belongs to the SF3A3 family
    Similarity: Contains 1 matrin-type zinc finger


    Find genes that share domains with SF3A3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SF3A3_HUMAN, Q12874
    Function: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2
    snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream
    of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of
    the 'E' complex

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SF3A3           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for SF3A3:
     Cell division defect  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 
     Decreased viability of wild-ty  Increased G2M DNA content  Increased gamma-H2AX phosphory  Increased mitotic index 
     Increased number of mitotic ce 

    Animal Models:
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    miRTarBase miRNAs that target SF3A3:
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    Selected qRT-PCR Assays for microRNAs that regulate SF3A3 (see all 16):
    hsa-miR-3194-5p hsa-miR-3146 hsa-miR-539 hsa-miR-2110 hsa-miR-532-5p hsa-miR-3121-3p hsa-miR-577 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidSF3A3 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SF3A3_HUMAN, Q12874: Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with SF3A3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SF3A3 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome
    4Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    Find genes that share SuperPaths with SF3A3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SF3A3
        Diurnally regulated genes with circadian orthologs
    mRNA processing


    1 Reactome Pathway for SF3A3
        mRNA Splicing - Major Pathway


    1 Kegg Pathway  (Kegg details for SF3A3):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SF3A3
    Interactions:

        GeneGlobe Interaction Network for SF3A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SF3A3 (Q128741, 2, 3 ENSP000003621104) via UniProtKB, MINT, STRING, and/or I2D (see all 969)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A1Q154591, 2, 3, ENSP000002157934EBI-1051880,EBI-1054743 MINT-8332306 MINT-8333394 MINT-7945693 MINT-7947479 I2D: score=5 STRING: ENSP00000215793
    SF3A2Q154282, 3, ENSP000002214944MINT-5205458 MINT-7947479 I2D: score=2 STRING: ENSP00000221494
    USO1O607632, 3MINT-7947479 I2D: score=4 
    PRPF40AO754002, 3MINT-7945693 I2D: score=2 
    U2AF1Q010812, 3, ENSP000002915524MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000291552
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000375RNA splicing, via transesterification reactions TAS7816610
    GO:0000389mRNA 3'-splice site recognition TAS15647371
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing IMP15647371
    GO:0008380RNA splicing TAS--

    Find genes that share ontologies with SF3A3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SF3A3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SF3A3 gene: 
    NM_006802.2  

    Unigene Cluster for SF3A3:

    Splicing factor 3a, subunit 3, 60kDa
    Hs.77897  [show with all ESTs]
    Unigene Representative Sequence: AK128438
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373019(uc001cci.3 uc010oik.2) ENST00000487062 ENST00000460925
    ENST00000489537 ENST00000461869 ENST00000470585 ENST00000488934 ENST00000462258
    ENST00000448721
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    hsa-miR-3194-5p hsa-miR-3146 hsa-miR-539 hsa-miR-2110 hsa-miR-532-5p hsa-miR-3121-3p hsa-miR-577 hsa-miR-3163
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    Additional mRNA sequence: 

    AK026887.1 AK128438.1 AK222554.1 AK291181.1 AK292116.1 AK301424.1 BC002395.2 BC011523.1 
    U08815.1 

    Selected DOTS entries (see all 31):

    DT.87017051  DT.95163258  DT.100671034  DT.91960453  DT.99932270  DT.97869217  DT.121443161  DT.100671022 
    DT.100641586  DT.121443195  DT.40116561  DT.100671023  DT.100671052  DT.121443156  DT.121443194  DT.92408106 
    DT.100671039  DT.120737471  DT.95101879  DT.100671032  DT.100671050  DT.95163257  DT.100671030  DT.101971451 

    Selected AceView cDNA sequences (see all 521):

    CR614728 AU130806 AU121563 CR610905 AI872485 CN485333 BE795571 AI982570 
    AI624327 BU181308 AU120298 BX417955 AA443032 BM702776 BM921950 AI492054 
    BM845155 BE243512 AU133806 AA302396 CR603079 BF797185 BG944892 CB160564 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SF3A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCAGATT
    SF3A3 Expression
    About this image


    SF3A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    SF3A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SF3A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77897

    UniProtKB/Swiss-Prot: SF3A3_HUMAN, Q12874
    Tissue specificity: Ubiquitous

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SF3A3 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sf3a31 , 5 splicing factor 3a, subunit 31, 5 91.28(n)1
    99.2(a)1
      4 (57.88 cM)5
    750621  NM_029157.31  NP_083433.11 
     1247147765 
    chicken
    (Gallus gallus)
    Aves SF3A31 splicing factor 3a, subunit 3, 60kDa 82.57(n)
    97.01(a)
      419608  XM_001232934.3  XP_001232935.1 
    lizard
    (Anolis carolinensis)
    Reptilia SF3A36
    splicing factor 3a, subunit 3, 60kDa
    96(a)
    1 ↔ 1
    GL343426.1(602827-610392)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.273142 Xenopus laevis transcribed sequence with moderate similarity more 81.56(n)    CA972483.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sf3a31 splicing factor 3a, subunit 3 79.77(n)
    91.02(a)
      446168  NM_001004289.1  NP_001004289.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta noi1 , 3 mRNA splicing pre-mRNA splicing factor3
    noisette1
    63(a)3
    62.05(n)1
    65.46(a)1
      83B43
    406781  NM_057766.51  NP_477114.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T13H5.41 , 3 PRP9 like protein3
    T13H5.41
    52(a)3
    55.96(n)1
    52.61(a)1
      II(8523543-8525316)3
    1743641  NM_063398.51  NP_495799.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP9(YDL030W)4 Subunit of the SF3a splicing factor complex, required more   --   4(397537-399129) 851531  NP_010254.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATO1 ATO 52.12(n)
    46.11(a)
      830503  NM_120698.4  NP_196234.3 
    rice
    (Oryza sativa)
    Liliopsida Os.116692 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.62(n)    AK069120.1 


    ENSEMBL Gene Tree for SF3A3 (if available)
    TreeFam Gene Tree for SF3A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SF3A3 gene
    SDE22  

    Find genes that share paralogs with SF3A3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SF3A3
    PGOHUM00000242518 PGOHUM00000247429


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SF3A3 (see all 831)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358575761,2
    C--38422237(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- ds50011NA 2
    rs1918795721,2
    --38422245(+) GACGGA/CGTCTC 1 -- ds50010--------
    rs121207371,2
    C,F,H--38422544(+) AGATAT/CATTAG 1 -- ds500123Minor allele frequency- C:0.38NS EA NA WA 2488
    rs121214501,2
    C,F,H--38422571(+) TGGGAC/TGAGTG 1 -- ds500117Minor allele frequency- T:0.05NS EA NA WA CSA 796
    rs121214561,2
    C,H--38422593(+) CTTGGC/TAGGTT 1 -- ds500117Minor allele frequency- T:0.00NS EA NA WA CSA 800
    rs1847361171,2
    --38422612(+) AATAAG/TATATA 1 -- ds50010--------
    rs1891870341,2
    --38422627(+) TGTAAC/TATAAA 1 -- ds50010--------
    rs1998361831,2
    --38422663(+) AGTAG-/ATTT  
            
    ATTAA
    1 -- ut310--------
    rs1491456301,2
    --38422666(+) AGATTA/TATTAA 1 -- ut310--------
    rs1432294351,2
    --38422884(+) GAGAAA/CATGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SF3A3 (38422647 - 38456593 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SF3A3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv267758CNV Insertion20981092
    nsv822331CNV Loss20364138
    nsv870730CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SF3A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SF3A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605596    OMIM disorders: --


    Find genes that share disorders with SF3A3           About GenesLikeMe


    Export disorders for SF3A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SF3A3 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with SF3A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Splicing factor SF3a60 is the mammalian homologue of PRP9 of S.cerevisiae: the conserved zinc finger-like motif is functionally exchangeable in vivo. (PubMed id 7816610)1, 2, 3 Kraemer A.... Bilbe G. (Nucleic Acids Res. 1994)
    2. Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114. (PubMed id 8022796)1, 2, 3 Chiara M.D.... Reed R. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    3. Solution structures of the SURP domains and the subunit-assembly mechanism within the splicing factor SF3a complex in 17S U2 snRNP. (PubMed id 17098193)1, 2 Kuwasako K.... Yokoyama S. (Structure 2006)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    8. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. (PubMed id 10882114)1, 2 Das R.... Reed R. (Mol. Cell 2000)
    9. Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. (PubMed id 11533230)1, 9 Nesic D. and KrAomer A. (Mol. Cell. Biol. 2001)
    10. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10946 HGNC: 10767 AceView: SF3A3 Ensembl:ENSG00000183431 euGenes: HUgn10946
    ECgene: SF3A3 Kegg: 10946 H-InvDB: SF3A3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SF3A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SF3A3 gene:
    Search GeneIP for patents involving SF3A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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