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Aliases for SF3A3 Gene

Aliases for SF3A3 Gene

  • Splicing Factor 3a, Subunit 3, 60kDa 2 3
  • SF3a60 3 4 6
  • SAP61 3 4 6
  • Splicing Factor 3a, Subunit 3, 60kD 2 3
  • Spliceosome-Associated Protein 61 3 4
  • SAP 61 3 4
  • PRP9 3 6
  • Pre-MRNA Splicing Factor SF3a (60kD) 3
  • Spliceosome Associated Protein 61 3
  • Splicing Factor 3A Subunit 3 3
  • PRPF9 3

External Ids for SF3A3 Gene

Summaries for SF3A3 Gene

Entrez Gene Summary for SF3A3 Gene

  • This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. [provided by RefSeq, Jul 2008]

GeneCards Summary for SF3A3 Gene

SF3A3 (Splicing Factor 3a, Subunit 3, 60kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and Diurnally regulated genes with circadian orthologs. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SDE2.

UniProtKB/Swiss-Prot for SF3A3 Gene

  • Subunit of the splicing factor SF3A required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex

Gene Wiki entry for SF3A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SF3A3 Gene

Genomics for SF3A3 Gene

Genomic Location for SF3A3 Gene

Start:
37,956,975 bp from pter
End:
37,990,921 bp from pter
Size:
33,947 bases
Orientation:
Minus strand

Genomic View for SF3A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SF3A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SF3A3 Gene

Regulatory Elements for SF3A3 Gene

Proteins for SF3A3 Gene

  • Protein details for SF3A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12874-SF3A3_HUMAN
    Recommended name:
    Splicing factor 3A subunit 3
    Protein Accession:
    Q12874
    Secondary Accessions:
    • D3DPT5
    • Q15460
    • Q5VT87

    Protein attributes for SF3A3 Gene

    Size:
    501 amino acids
    Molecular mass:
    58849 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interacts with SF3A1, through its N-terminal region.

    Three dimensional structures from OCA and Proteopedia for SF3A3 Gene

neXtProt entry for SF3A3 Gene

Proteomics data for SF3A3 Gene at MOPED

Post-translational modifications for SF3A3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys201 and Lys390

Other Protein References for SF3A3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SF3A3 Gene

Domains for SF3A3 Gene

Protein Domains for SF3A3 Gene

UniProtKB/Swiss-Prot:

SF3A3_HUMAN
Family:
  • Belongs to the SF3A3 family.:
    • Q12874
Similarity:
  • Contains 1 matrin-type zinc finger.:
    • Q12874
genes like me logo Genes that share domains with SF3A3: view

No data available for Gene Families for SF3A3 Gene

Function for SF3A3 Gene

Molecular function for SF3A3 Gene

UniProtKB/Swiss-Prot Function: Subunit of the splicing factor SF3A required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex

Gene Ontology (GO) - Molecular Function for SF3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 22190034
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SF3A3: view
genes like me logo Genes that share phenotypes with SF3A3: view

miRNA for SF3A3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SF3A3 Gene

Localization for SF3A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SF3A3 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SF3A3 Gene COMPARTMENTS Subcellular localization image for SF3A3 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SF3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0016607 nuclear speck IEA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with SF3A3: view

Pathways for SF3A3 Gene

genes like me logo Genes that share pathways with SF3A3: view

Pathways by source for SF3A3 Gene

Gene Ontology (GO) - Biological Process for SF3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions TAS 7816610
GO:0000389 mRNA 3-splice site recognition TAS 15647371
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IMP 15647371
GO:0008380 RNA splicing TAS --
genes like me logo Genes that share ontologies with SF3A3: view

Transcripts for SF3A3 Gene

Unigene Clusters for SF3A3 Gene

Splicing factor 3a, subunit 3, 60kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SF3A3 Gene

No ASD Table

Relevant External Links for SF3A3 Gene

GeneLoc Exon Structure for
SF3A3
ECgene alternative splicing isoforms for
SF3A3

Expression for SF3A3 Gene

mRNA expression in normal human tissues for SF3A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SF3A3 Gene

SOURCE GeneReport for Unigene cluster for SF3A3 Gene Hs.77897

mRNA Expression by UniProt/SwissProt for SF3A3 Gene

Q12874-SF3A3_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with SF3A3: view

Orthologs for SF3A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SF3A3 36
  • 99.93 (n)
  • 100 (a)
SF3A3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SF3A3 36
  • 93.21 (n)
  • 99.6 (a)
SF3A3 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 100 (a)
OneToMany
-- 37
  • 100 (a)
OneToMany
SF3A3 36
  • 92.02 (n)
  • 99.8 (a)
mouse
(Mus musculus)
Mammalia Sf3a3 36
  • 91.28 (n)
  • 99.2 (a)
Sf3a3 16
Sf3a3 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 79 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SF3A3 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sf3a3 36
  • 91.88 (n)
  • 99.2 (a)
chicken
(Gallus gallus)
Aves SF3A3 36
  • 82.57 (n)
  • 97.01 (a)
SF3A3 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SF3A3 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.27314 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sf3a3 36
  • 80.57 (n)
  • 93.01 (a)
Str.78 36
zebrafish
(Danio rerio)
Actinopterygii sf3a3 36
  • 79.77 (n)
  • 91.02 (a)
sf3a3 37
  • 91 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta noi 36
  • 62.05 (n)
  • 65.46 (a)
noi 37
  • 65 (a)
OneToOne
noi 38
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea T13H5.4 36
  • 55.96 (n)
  • 52.61 (a)
T13H5.4 37
  • 52 (a)
OneToOne
T13H5.4 38
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP9 37
  • 22 (a)
OneToMany
PRP9 39
thale cress
(Arabidopsis thaliana)
eudicotyledons ATO 36
  • 52.12 (n)
  • 46.11 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3335 36
corn
(Zea mays)
Liliopsida Zm.6441 36
rice
(Oryza sativa)
Liliopsida Os.11669 36
Os03g0717600 36
  • 52 (n)
  • 45.42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1167 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 68 (a)
OneToOne
Species with no ortholog for SF3A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SF3A3 Gene

ENSEMBL:
Gene Tree for SF3A3 (if available)
TreeFam:
Gene Tree for SF3A3 (if available)

Paralogs for SF3A3 Gene

Paralogs for SF3A3 Gene

Pseudogenes.org Pseudogenes for SF3A3 Gene

genes like me logo Genes that share paralogs with SF3A3: view

Variants for SF3A3 Gene

Sequence variations from dbSNP and Humsavar for SF3A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9293 -- 37,958,181(-) GTGTT(C/G)AGGGA utr-variant-3-prime
rs9686 -- 37,957,278(-) ACTGG(A/T)GGGTC utr-variant-3-prime
rs1050257 -- 37,957,916(-) CTTAA(C/T)GCCTC utr-variant-3-prime
rs1802611 -- 37,969,374(-) CCAAA(G/T)CCTTC reference, missense
rs1802612 -- 37,958,069(-) GTCTA(G/T)CATGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SF3A3 Gene

Variant ID Type Subtype PubMed ID
nsv870730 CNV Gain 21882294
nsv822331 CNV Loss 20364138
esv267758 CNV Insertion 20981092

Relevant External Links for SF3A3 Gene

HapMap Linkage Disequilibrium report
SF3A3

Disorders for SF3A3 Gene

No disorders were found for SF3A3 Gene.

No data available for UniProtKB/Swiss-Prot for SF3A3 Gene

Publications for SF3A3 Gene

  1. Splicing factor SF3a60 is the mammalian homologue of PRP9 of S.cerevisiae: the conserved zinc finger-like motif is functionally exchangeable in vivo. (PMID: 7816610) Kraemer A. … Bilbe G. (Nucleic Acids Res. 1994) 2 3 4
  2. Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114. (PMID: 8022796) Chiara M.D. … Reed R. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4
  3. Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. (PMID: 11533230) Nesic D. … KrAomer A. (Mol. Cell. Biol. 2001) 3 23
  4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SF3A3 Gene

Sources for SF3A3 Gene

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