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Aliases for SF3A2 Gene

Aliases for SF3A2 Gene

  • Splicing Factor 3a, Subunit 2, 66kDa 2 3
  • SAP62 3 4 6
  • Splicing Factor 3a, Subunit 2, 66kD 2 3
  • Spliceosome-Associated Protein 62 3 4
  • SAP 62 3 4
  • SF3a66 3 4
  • PRP11 3 6
  • Pre-MRNA Splicing Factor SF3A, Subunit 2 3
  • Spliceosome Associated Protein 62 3
  • Splicing Factor 3A Subunit 2 3
  • PRPF11 3

External Ids for SF3A2 Gene

Previous GeneCards Identifiers for SF3A2 Gene

  • GC19P002299
  • GC19P002176
  • GC19P002187
  • GC19P002174
  • GC19P002007

Summaries for SF3A2 Gene

Entrez Gene Summary for SF3A2 Gene

  • This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SF3A2 Gene

SF3A2 (Splicing Factor 3a, Subunit 2, 66kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SF3A2 Gene

  • Subunit of the splicing factor SF3A required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex

Gene Wiki entry for SF3A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SF3A2 Gene

Genomics for SF3A2 Gene

Regulatory Elements for SF3A2 Gene

Genomic Location for SF3A2 Gene

Start:
2,236,504 bp from pter
End:
2,248,679 bp from pter
Size:
12,176 bases
Orientation:
Plus strand

Genomic View for SF3A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SF3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SF3A2 Gene

Proteins for SF3A2 Gene

  • Protein details for SF3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15428-SF3A2_HUMAN
    Recommended name:
    Splicing factor 3A subunit 2
    Protein Accession:
    Q15428
    Secondary Accessions:
    • B2RBU1
    • D6W605
    • O75245

    Protein attributes for SF3A2 Gene

    Size:
    464 amino acids
    Molecular mass:
    49256 Da
    Quaternary structure:
    • Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Identified in the spliceosome C complex. Interacts with HTATSF1.

neXtProt entry for SF3A2 Gene

Proteomics data for SF3A2 Gene at MOPED

Post-translational modifications for SF3A2 Gene

  • Ubiquitination at Lys48 and Lys194
  • Modification sites at PhosphoSitePlus

Other Protein References for SF3A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SF3A2 Gene

Domains for SF3A2 Gene

Protein Domains for SF3A2 Gene

Suggested Antigen Peptide Sequences for SF3A2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15428

UniProtKB/Swiss-Prot:

SF3A2_HUMAN :
  • Q15428
Family:
  • Belongs to the SF3A2 family.
Similarity:
  • Contains 1 matrin-type zinc finger.
genes like me logo Genes that share domains with SF3A2: view

No data available for Gene Families for SF3A2 Gene

Function for SF3A2 Gene

Molecular function for SF3A2 Gene

UniProtKB/Swiss-Prot Function: Subunit of the splicing factor SF3A required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex

Gene Ontology (GO) - Molecular Function for SF3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 17332742
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SF3A2: view

Phenotypes for SF3A2 Gene

genes like me logo Genes that share phenotypes with SF3A2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SF3A2 Gene

Localization for SF3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SF3A2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SF3A2 Gene COMPARTMENTS Subcellular localization image for SF3A2 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SF3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0030532 small nuclear ribonucleoprotein complex TAS 8211113
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with SF3A2: view

Pathways for SF3A2 Gene

genes like me logo Genes that share pathways with SF3A2: view

Pathways by source for SF3A2 Gene

1 KEGG pathway for SF3A2 Gene

Gene Ontology (GO) - Biological Process for SF3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000389 mRNA 3-splice site recognition TAS 15647371
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IMP 15647371
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SF3A2: view

Transcripts for SF3A2 Gene

mRNA/cDNA for SF3A2 Gene

Unigene Clusters for SF3A2 Gene

Splicing factor 3a, subunit 2, 66kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SF3A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for SF3A2 Gene

GeneLoc Exon Structure for
SF3A2
ECgene alternative splicing isoforms for
SF3A2

Expression for SF3A2 Gene

mRNA expression in normal human tissues for SF3A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SF3A2 Gene

SOURCE GeneReport for Unigene cluster for SF3A2 Gene Hs.115232

genes like me logo Genes that share expressions with SF3A2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SF3A2 Gene

Orthologs for SF3A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SF3A2 35
  • 99.5 (n)
  • 100 (a)
SF3A2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SF3A2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SF3A2 35
  • 87.83 (n)
  • 95.68 (a)
SF3A2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sf3a2 16
Sf3a2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SF3A2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SF3A2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves SF3A2 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sf3a2-prov 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.198 35
zebrafish
(Danio rerio)
Actinopterygii sf3a2 36
  • 87 (a)
OneToOne
zgc56097 35
fruit fly
(Drosophila melanogaster)
Insecta CG10754 36
  • 78 (a)
OneToOne
CG10754 37
  • 84 (a)
worm
(Caenorhabditis elegans)
Secernentea repo-1 36
  • 77 (a)
OneToOne
F11A10.2 37
  • 78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP11 36
  • 27 (a)
OneToOne
PRP11 38
barley
(Hordeum vulgare)
Liliopsida Hv.954 35
corn
(Zea mays)
Liliopsida Zm.8991 35
rice
(Oryza sativa)
Liliopsida Os.5848 35
wheat
(Triticum aestivum)
Liliopsida Ta.8406 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2164 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2750 36
  • 62 (a)
OneToOne
Species with no ortholog for SF3A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for SF3A2 Gene

ENSEMBL:
Gene Tree for SF3A2 (if available)
TreeFam:
Gene Tree for SF3A2 (if available)

Paralogs for SF3A2 Gene

Pseudogenes.org Pseudogenes for SF3A2 Gene

genes like me logo Genes that share paralogs with SF3A2: view

No data available for Paralogs for SF3A2 Gene

Variants for SF3A2 Gene

Sequence variations from dbSNP and Humsavar for SF3A2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs733846 -- 2,241,328(+) GTTCG(G/T)TGCTG intron-variant
rs757595 -- 2,241,407(+) CTGCT(C/T)GCTGG intron-variant
rs1053975 -- 2,246,998(+) GCCGA(A/G)CCCTA synonymous-codon, reference
rs1990213 -- 2,242,142(+) CTGCC(A/G)CCACT intron-variant
rs1990214 -- 2,242,391(+) tgtgt(C/G)ccttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SF3A2 Gene

Variant ID Type Subtype PubMed ID
nsv910499 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
dgv3622n71 CNV Loss 21882294
dgv3626n71 CNV Loss 21882294
nsv910623 CNV Loss 21882294
dgv3629n71 CNV Loss 21882294
dgv3630n71 CNV Loss 21882294
nsv833706 CNV Loss 17160897
dgv3631n71 CNV Loss 21882294
nsv833707 CNV Loss 17160897
nsv2389 CNV Insertion 18451855
nsv910636 CNV Loss 21882294
dgv3632n71 CNV Loss 21882294
dgv3633n71 CNV Loss 21882294
nsv828396 CNV Loss 20364138
dgv3634n71 CNV Loss 21882294
esv2717881 CNV Deletion 23290073
esv1711865 CNV Insertion 17803354

Relevant External Links for SF3A2 Gene

HapMap Linkage Disequilibrium report
SF3A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SF3A2 Gene

Disorders for SF3A2 Gene

Relevant External Links for SF3A2

Genetic Association Database (GAD)
SF3A2
Human Genome Epidemiology (HuGE) Navigator
SF3A2
genes like me logo Genes that share disorders with SF3A2: view

No data available for UniProtKB/Swiss-Prot for SF3A2 Gene

Publications for SF3A2 Gene

  1. Correspondence between a mammalian spliceosome component and an essential yeast splicing factor. (PMID: 8211113) Bennett M. … Reed R. (Science 1993) 2 3 4
  2. The genes for a spliceosome protein (SAP62) and the anti-MA1llerian hormone (AMH) are contiguous. (PMID: 8541848) Dresser D.W. … Guerrier D. (Hum. Mol. Genet. 1995) 2 3
  3. Essential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution. (PMID: 8718683) Rain J.C. … Legrain P. (RNA 1996) 3 23
  4. Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. (PMID: 11533230) Nesic D. … KrAomer A. (Mol. Cell. Biol. 2001) 3 23
  5. An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH. (PMID: 11602354) Dresser D.W. … Guerrier D. (Gene 2001) 3 23

Products for SF3A2 Gene

Sources for SF3A2 Gene

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