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SF3A2 Gene

protein-coding   GIFtS: 61
GCID: GC19P002236

Splicing Factor 3a, Subunit 2, 66kDa

(Previous names: splicing factor 3a, subunit 2, 66kD)
  Search for SF3A2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Splicing Factor 3a, Subunit 2, 66kDa1 2     Splicing Factor 3a, Subunit 2, 66kD1
SAP622 3 5     PRPF112
Spliceosome-Associated Protein 622 3     Pre-MRNA Splicing Factor SF3A, Subunit 22
SF3a662 3     Spliceosome Associated Protein 622
SAP 622 3     Splicing Factor 3A Subunit 22
PRP112 5     

External Ids:    HGNC: 107661   Entrez Gene: 81752   Ensembl: ENSG000001048977   OMIM: 6007965   UniProtKB: Q154283   

Export aliases for SF3A2 gene to outside databases

Previous GC identifers: GC19P002299 GC19P002176 GC19P002187 GC19P002174 GC19P002007


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SF3A2 Gene:
This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer
includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S
particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the
single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also
function independently of its RNA splicing function as a microtubule-binding protein. (provided by RefSeq, Jul
2008)

GeneCards Summary for SF3A2 Gene:
SF3A2 (splicing factor 3a, subunit 2, 66kDa) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot: SF3A2_HUMAN, Q15428
Function: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2
snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream
of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of
the 'E' complex

Gene Wiki entry for SF3A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the SF3A2 gene promoter:
         Spz1   p53   AP-1   ATF-2   GATA-1   CREB   deltaCREB   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSF3A2 promoter sequence
   Search Chromatin IP Primers for SF3A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SF3A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

SF3A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SF3A2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P002236:  view genomic region     (about GC identifiers)

Start:
2,236,520 bp from pter      End:
2,248,678 bp from pter
Size:
12,159 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SF3A2_HUMAN, Q15428 (See protein sequence)
Recommended Name: Splicing factor 3A subunit 2  
Size: 464 amino acids; 49256 Da
Subunit: Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62,
SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear
ribonucleoproteins complex (U2 snRNP). Identified in the spliceosome C complex. Interacts with HTATSF1
Secondary accessions: B2RBU1 D6W605 O75245

Explore the universe of human proteins at neXtProt for SF3A2: NX_Q15428

Explore proteomics data for SF3A2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys48, Lys194
  • Modification sites at PhosphoSitePlus

  • See SF3A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009096.2  
    ENSEMBL proteins: 
     ENSP00000221494   ENSP00000466634  
    Reactome Protein details: Q15428

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003604 Znf_U1
     IPR015880 Znf_C2H2-like
     IPR000690 Znf_C2H2_matrin
     IPR019134 Cactin_C

    Graphical View of Domain Structure for InterPro Entry Q15428

    ProtoNet protein and cluster: Q15428

    1 Blocks protein domain: IPB003604 Zn-finger

    UniProtKB/Swiss-Prot: SF3A2_HUMAN, Q15428
    Similarity: Belongs to the SF3A2 family
    Similarity: Contains 1 matrin-type zinc finger


    Find genes that share domains with SF3A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SF3A2_HUMAN, Q15428
    Function: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2
    snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream
    of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of
    the 'E' complex

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI17332742
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SF3A2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SF3A2:
     Decreased viability of wild-ty  Increased mitotic index 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SF3A2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SF3A2_HUMAN, Q15428: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0030532small nuclear ribonucleoprotein complex TAS8211113
    GO:0071013catalytic step 2 spliceosome IDA11991638

    Find genes that share ontologies with SF3A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SF3A2 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome


    Find genes that share SuperPaths with SF3A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SF3A2
        mRNA processing

    1 Reactome Pathway for SF3A2
        mRNA Splicing - Major Pathway


    1 Kegg Pathway  (Kegg details for SF3A2):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SF3A2
    Interactions:

        GeneGlobe Interaction Network for SF3A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SF3A2 (Q154281, 2, 3 ENSP000002214944) via UniProtKB, MINT, STRING, and/or I2D (see all 720)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A1Q154591, 2, 3, ENSP000002157934EBI-2462271,EBI-1054743 MINT-5205440 MINT-8332317 MINT-7947479 MINT-8333383 I2D: score=5 STRING: ENSP00000215793
    DDX42Q86XP32, 3, ENSP000003523084MINT-5205620 MINT-7947479 I2D: score=2 STRING: ENSP00000352308
    RBM17Q96I252, 3, ENSP000003692184MINT-5205539 MINT-7947479 I2D: score=2 STRING: ENSP00000369218
    SF3B1O755332, 3, ENSP000003353214MINT-5205467 MINT-7947479 I2D: score=2 STRING: ENSP00000335321
    SF3B2Q134352, 3, ENSP000003188614MINT-5205476 MINT-7947479 I2D: score=2 STRING: ENSP00000318861
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000389mRNA 3'-splice site recognition TAS15647371
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing IMP15647371
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with SF3A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SF3A2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SF3A2 gene: 
    NM_007165.4  

    Unigene Cluster for SF3A2:

    Splicing factor 3a, subunit 2, 66kDa
    Hs.115232  [show with all ESTs]
    Unigene Representative Sequence: BM562780
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221494(uc002lvg.3) ENST00000592839 ENST00000592314 ENST00000586396
    ENST00000591121 ENST00000590034 ENST00000589118 ENST00000587637
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SF3A2
      QuantiFast Probe-based Assays in human, mouse, rat SF3A2

    Additional mRNA sequence: 

    AK314815.1 BC004434.1 BC009903.2 BC015804.1 

    Selected DOTS entries (see all 25):

    DT.100656077  DT.95355671  DT.403963  DT.97811329  DT.92445326  DT.92445324  DT.100701364  DT.40307359 
    DT.100713027  DT.100792678  DT.100792667  DT.121414594  DT.100792668  DT.95355677  DT.91950944  DT.99998968 
    DT.121414375  DT.100792675  DT.100792680  DT.102841008  DT.91948652  DT.97825635  DT.100805745  DT.121414720 

    Selected AceView cDNA sequences (see all 337):

    BQ448096 CA394998 BQ220299 AI702383 CR591027 CR618008 BQ898149 BU189483 
    BQ898980 BC015804 BU844913 BQ928455 BG912023 BE900620 AA588895 BQ428045 
    BM926753 BM763040 CR619415 AI702367 CR596440 BM846230 BM451960 CA398123 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SF3A2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
    SP1:                    -                             -     -           -                                       
    SP2:                    -                             -     -           -                                       
    SP3:                                                  -     -           -                                       
    SP4:                    -                             -     -                                                   
    SP5:                    -                                                                                       


    ECgene alternative splicing isoforms for SF3A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SF3A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCAATGC
    SF3A2 Expression
    About this image


    SF3A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    SF3A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SF3A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.115232
        Custom PCR Arrays for SF3A2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SF3A2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sf3a25 splicing factor 3a, subunit 2   --   10 (39.72 cM) 80798198 
    chicken
    (Gallus gallus)
    Aves SF3A26
    Gallus gallus splicing factor 3a, subunit 2, 66kDa...
    93(a)
    1 ↔ 1
    28(1962063-1966197)
    African clawed frog
    (Xenopus laevis)
    Amphibia sf3a2-prov2 splicing factor 3a, subunit 2, 66kDa 76.19(n)    BC041254.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560972 similar to splicing factor 3a, subunit 2, 66kDa 80.12(n)   394018  BC045907.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG107543 mRNA splicing pre-mRNA splicing factor 84(a)   69E4   --
    worm
    (Caenorhabditis elegans)
    Secernentea F11A10.23   -- 78(a)   IV(12084650-12085400)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP11(YDL043C)4 Subunit of the SF3a splicing factor complex, required more   --   4(376480-375680) 851518  NP_010241.1 
    rice
    (Oryza sativa)
    Liliopsida Os.58482 Oryza sativa (japonica cultivar-group) cDNA clone0 more 75.78(n)    NM_187526.1 


    ENSEMBL Gene Tree for SF3A2 (if available)
    TreeFam Gene Tree for SF3A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SF3A2 gene

    Find genes that share paralogs with SF3A2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SF3A2
    PGOHUM00000237752


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SF3A2 (see all 257)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394810701,2
    C--2238355(+) TTTACC/TAGGTT 1 -- int10--------
    rs1859974301,2
    --2238373(+) CTGTCC/GCCTGA 1 -- int10--------
    rs1500524321,2
    C--2238445(+) TGATTG/TCTTGT 1 -- int10--------
    rs2011708561,2
    --2238464(+) TTGAG-/ATCTTCTC 1 -- int10--------
    rs2010692501,2
    C--2238465(+) TTGAG-/TCTCTTCT 1 -- int10--------
    rs1461596981,2
    --2238633(+) CTATCC/TTCCCT 1 -- int10--------
    rs72531811,2
    C,F,A,H--2238667(+) ACCATT/GAGCCT 1 -- int124Minor allele frequency- G:0.36NS EA NA WA CSA 2353
    rs784814931,2
    C,F--2238719(+) CCCACC/ATCTCA 1 -- int12Minor allele frequency- A:0.03NA EA 240
    rs729854861,2
    C,F--2238730(+) CACACC/TTATCA 1 -- int11Minor allele frequency- T:0.01NA 120
    rs790997181,2
    C,F--2238905(+) CAGTGT/AGGTCA 1 -- int12Minor allele frequency- A:0.08CSA EA 122

    HapMap Linkage Disequilibrium report for SF3A2 (2236520 - 2248678 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SF3A2 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717881CNV Deletion23290073
    nsv2389CNV Insertion18451855
    esv1711865CNV Insertion17803354
    dgv3634n71CNV Loss21882294
    dgv3614n71CNV Loss21882294
    nsv910499CNV Loss21882294
    dgv3633n71CNV Loss21882294
    nsv833706CNV Loss17160897
    nsv910623CNV Loss21882294
    nsv833707CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600796    OMIM disorders: --


    Find genes that share disorders with SF3A2           About GenesLikeMe

    Genetic Association Database (GAD): SF3A2
    Human Genome Epidemiology (HuGE) Navigator: SF3A2 (1 document)

    Export disorders for SF3A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SF3A2 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with SF3A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Correspondence between a mammalian spliceosome component and an essential yeast splicing factor. (PubMed id 8211113)1, 2, 3 Bennett M. and Reed R. (Science 1993)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    6. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. (PubMed id 10882114)1, 2 Das R.... Reed R. (Mol. Cell 2000)
    7. CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif. (PubMed id 9710584)1, 2 Yan D.... Ares M. Jr. (Mol. Cell. Biol. 1998)
    8. The genes for a spliceosome protein (SAP62) and the anti-MA1llerian hormone (AMH) are contiguous. (PubMed id 8541848)1, 3 Dresser D.W....Guerrier D. (Hum. Mol. Genet. 1995)
    9. The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein. (PubMed id 15142036)1, 9 Takenaka K....Miki H. (Biochem. J. 2004)
    10. Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. (PubMed id 11533230)1, 9 Nesic D. and KrAomer A. (Mol. Cell. Biol. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8175 HGNC: 10766 AceView: AMHandSF3A2 Ensembl:ENSG00000104897 euGenes: HUgn8175
    ECgene: SF3A2 Kegg: 8175 H-InvDB: SF3A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SF3A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SF3A2 gene:
    Search GeneIP for patents involving SF3A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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