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Aliases for SF3A2 Gene

Aliases for SF3A2 Gene

  • Splicing Factor 3a Subunit 2 2 3 5
  • Splicing Factor 3a, Subunit 2, 66kDa 2 3
  • Splicing Factor 3a, Subunit 2, 66kD 2 3
  • Spliceosome-Associated Protein 62 3 4
  • SAP 62 3 4
  • SF3a66 3 4
  • SAP62 3 4
  • Pre-MRNA Splicing Factor SF3A, Subunit 2 3
  • Spliceosome Associated Protein 62 3
  • PRPF11 3
  • PRP11 3

External Ids for SF3A2 Gene

Previous GeneCards Identifiers for SF3A2 Gene

  • GC19P002299
  • GC19P002176
  • GC19P002187
  • GC19P002174
  • GC19P002007

Summaries for SF3A2 Gene

Entrez Gene Summary for SF3A2 Gene

  • This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SF3A2 Gene

SF3A2 (Splicing Factor 3a Subunit 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding.

UniProtKB/Swiss-Prot for SF3A2 Gene

  • Subunit of the splicing factor SF3A required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex.

Gene Wiki entry for SF3A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SF3A2 Gene

Genomics for SF3A2 Gene

Regulatory Elements for SF3A2 Gene

Enhancers for SF3A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SF3A2 on UCSC Golden Path with GeneCards custom track

Promoters for SF3A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SF3A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SF3A2 Gene

Chromosome:
19
Start:
2,236,504 bp from pter
End:
2,248,679 bp from pter
Size:
12,176 bases
Orientation:
Plus strand

Genomic View for SF3A2 Gene

Genes around SF3A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SF3A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SF3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SF3A2 Gene

Proteins for SF3A2 Gene

  • Protein details for SF3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15428-SF3A2_HUMAN
    Recommended name:
    Splicing factor 3A subunit 2
    Protein Accession:
    Q15428
    Secondary Accessions:
    • B2RBU1
    • D6W605
    • O75245

    Protein attributes for SF3A2 Gene

    Size:
    464 amino acids
    Molecular mass:
    49256 Da
    Quaternary structure:
    • Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Identified in the spliceosome C complex. Interacts with HTATSF1.

neXtProt entry for SF3A2 Gene

Post-translational modifications for SF3A2 Gene

  • Ubiquitination at Lys 10, Lys 48, and Lys 194
  • Modification sites at PhosphoSitePlus

Other Protein References for SF3A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SF3A2 Gene

Domains & Families for SF3A2 Gene

Protein Domains for SF3A2 Gene

Suggested Antigen Peptide Sequences for SF3A2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15428

UniProtKB/Swiss-Prot:

SF3A2_HUMAN :
  • Belongs to the SF3A2 family.
  • Contains 1 matrin-type zinc finger.
Family:
  • Belongs to the SF3A2 family.
Similarity:
  • Contains 1 matrin-type zinc finger.
genes like me logo Genes that share domains with SF3A2: view

No data available for Gene Families for SF3A2 Gene

Function for SF3A2 Gene

Molecular function for SF3A2 Gene

UniProtKB/Swiss-Prot Function:
Subunit of the splicing factor SF3A required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex.

Gene Ontology (GO) - Molecular Function for SF3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17332742
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SF3A2: view
genes like me logo Genes that share phenotypes with SF3A2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SF3A2 Gene

Localization for SF3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SF3A2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SF3A2 Gene COMPARTMENTS Subcellular localization image for SF3A2 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SF3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005686 U2 snRNP IBA --
GO:0016607 nuclear speck IEA --
GO:0030532 small nuclear ribonucleoprotein complex TAS 8211113
genes like me logo Genes that share ontologies with SF3A2: view

Pathways & Interactions for SF3A2 Gene

genes like me logo Genes that share pathways with SF3A2: view

Pathways by source for SF3A2 Gene

1 KEGG pathway for SF3A2 Gene

Gene Ontology (GO) - Biological Process for SF3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000389 mRNA 3-splice site recognition TAS 15647371
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IMP 15647371
GO:0008380 RNA splicing TAS 8211113
GO:0010976 positive regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with SF3A2: view

No data available for SIGNOR curated interactions for SF3A2 Gene

Drugs & Compounds for SF3A2 Gene

No Compound Related Data Available

Transcripts for SF3A2 Gene

Unigene Clusters for SF3A2 Gene

Splicing factor 3a, subunit 2, 66kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SF3A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for SF3A2 Gene

GeneLoc Exon Structure for
SF3A2
ECgene alternative splicing isoforms for
SF3A2

Expression for SF3A2 Gene

mRNA expression in normal human tissues for SF3A2 Gene

Protein differential expression in normal tissues from HIPED for SF3A2 Gene

This gene is overexpressed in Nasal epithelium (10.3), Bone (8.6), and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SF3A2 Gene



Protein tissue co-expression partners for SF3A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SF3A2 Gene:

SF3A2

SOURCE GeneReport for Unigene cluster for SF3A2 Gene:

Hs.115232
genes like me logo Genes that share expression patterns with SF3A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SF3A2 Gene

Orthologs for SF3A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3A2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SF3A2 34
  • 87.83 (n)
  • 95.68 (a)
SF3A2 35
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SF3A2 34
  • 99.5 (n)
  • 100 (a)
SF3A2 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SF3A2 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SF3A2 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sf3a2 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SF3A2 35
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves SF3A2 35
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sf3a2-prov 34
zebrafish
(Danio rerio)
Actinopterygii zgc56097 34
sf3a2 35
  • 87 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.198 34
fruit fly
(Drosophila melanogaster)
Insecta CG10754 36
  • 84 (a)
CG10754 35
  • 78 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F11A10.2 36
  • 78 (a)
repo-1 35
  • 77 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP11 35
  • 27 (a)
OneToOne
PRP11 37
barley
(Hordeum vulgare)
Liliopsida Hv.954 34
rice
(Oryza sativa)
Liliopsida Os.5848 34
corn
(Zea mays)
Liliopsida Zm.8991 34
wheat
(Triticum aestivum)
Liliopsida Ta.8406 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2750 35
  • 62 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2164 34
Species where no ortholog for SF3A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for SF3A2 Gene

ENSEMBL:
Gene Tree for SF3A2 (if available)
TreeFam:
Gene Tree for SF3A2 (if available)

Paralogs for SF3A2 Gene

Pseudogenes.org Pseudogenes for SF3A2 Gene

genes like me logo Genes that share paralogs with SF3A2: view

No data available for Paralogs for SF3A2 Gene

Variants for SF3A2 Gene

Sequence variations from dbSNP and Humsavar for SF3A2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10425375 -- 2,247,088(+) TAGGC(C/T)GGGCA intron-variant
rs3761021 -- 2,241,053(-) ATCAC(C/T)GGTCT intron-variant
rs10518240 -- 2,239,967(+) GGGAT(A/T)CCCAT intron-variant
rs11557511 -- 2,243,463(+) GGGGG(C/T)GTGGC reference, synonymous-codon
rs78342093 -- 2,240,906(+) CAGGT(C/T)GCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SF3A2 Gene

Variant ID Type Subtype PubMed ID
dgv6218n54 CNV loss 21841781
esv1711865 CNV insertion 17803354
esv2717881 CNV deletion 23290073
nsv1110726 CNV insertion 24896259
nsv1125666 CNV tandem duplication 24896259
nsv2389 CNV insertion 18451855
nsv476713 CNV novel sequence insertion 20440878
nsv578382 CNV loss 21841781
nsv578383 CNV loss 21841781
nsv828396 CNV loss 20364138
nsv833706 CNV loss 17160897
nsv833707 CNV loss 17160897

Variation tolerance for SF3A2 Gene

Gene Damage Index Score: 1.21; 24.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SF3A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SF3A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SF3A2 Gene

Disorders for SF3A2 Gene

Relevant External Links for SF3A2

Genetic Association Database (GAD)
SF3A2
Human Genome Epidemiology (HuGE) Navigator
SF3A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SF3A2

No disorders were found for SF3A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SF3A2 Gene

Publications for SF3A2 Gene

  1. Correspondence between a mammalian spliceosome component and an essential yeast splicing factor. (PMID: 8211113) Bennett M. … Reed R. (Science 1993) 2 3 4 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 65
  4. The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein. (PMID: 15142036) Takenaka K. … Miki H. (Biochem. J. 2004) 3 22 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for SF3A2 Gene

Sources for SF3A2 Gene

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