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Aliases for SF3A2 Gene

Aliases for SF3A2 Gene

  • Splicing Factor 3a Subunit 2 2 3 5
  • Splicing Factor 3a, Subunit 2, 66kDa 2 3
  • Splicing Factor 3a, Subunit 2, 66kD 2 3
  • SAP 62 3 4
  • SF3a66 3 4
  • SAP62 3 4
  • Pre-MRNA Splicing Factor SF3A, Subunit 2 3
  • Spliceosome Associated Protein 62 3
  • Spliceosome-Associated Protein 62 4
  • PRPF11 3
  • PRP11 3

External Ids for SF3A2 Gene

Previous GeneCards Identifiers for SF3A2 Gene

  • GC19P002299
  • GC19P002176
  • GC19P002187
  • GC19P002174
  • GC19P002007

Summaries for SF3A2 Gene

Entrez Gene Summary for SF3A2 Gene

  • This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SF3A2 Gene

SF3A2 (Splicing Factor 3a Subunit 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SF3A2 Gene

  • Subunit of the splicing factor SF3A required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex.

Gene Wiki entry for SF3A2 Gene

Additional gene information for SF3A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SF3A2 Gene

Genomics for SF3A2 Gene

GeneHancer (GH) Regulatory Elements for SF3A2 Gene

Promoters and enhancers for SF3A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I002234 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 597.5 +3.0 3011 10.6 CLOCK MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SF3A2 PLEKHJ1 DAZAP1 ZNF77 AMH LOC100288123 TCF3 ENSG00000267317 DOT1L GNA11
GH19I001382 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 119.1 -852.5 -852478 2.2 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NDUFS7 PIR43938 PIR60227 TRF-GAA1-6 TRN-GTT2-6 CIRBP SF3A2 TMEM259 MUM1 TCF3
GH19I001236 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 104.9 -979.6 -979645 41.1 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 CIRBP C19orf24 MIDN CBARP ATP5F1D SF3A2 TCF3 TMEM259 LOC100288123 PTBP1
GH19I001437 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 80.9 -797.0 -797021 4.3 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC RPS15 ENSG00000268798 SF3A2 TCF3 TMEM259 LOC100288123 PTBP1 DAZAP1 MED16 ENSG00000267317
GH19I001406 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 49.4 -823.7 -823674 13.5 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D DAZAP1 TCF3 SF3A2 TMEM259 PTBP1 LOC100288123 GRIN3B RPS15 ENSG00000267317 CIRBP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SF3A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SF3A2 gene promoter:

Genomic Locations for SF3A2 Gene

Genomic Locations for SF3A2 Gene
chr19:2,236,504-2,248,679
(GRCh38/hg38)
Size:
12,176 bases
Orientation:
Plus strand
chr19:2,236,520-2,248,678
(GRCh37/hg19)

Genomic View for SF3A2 Gene

Genes around SF3A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SF3A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SF3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SF3A2 Gene

Proteins for SF3A2 Gene

  • Protein details for SF3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15428-SF3A2_HUMAN
    Recommended name:
    Splicing factor 3A subunit 2
    Protein Accession:
    Q15428
    Secondary Accessions:
    • B2RBU1
    • D6W605
    • O75245

    Protein attributes for SF3A2 Gene

    Size:
    464 amino acids
    Molecular mass:
    49256 Da
    Quaternary structure:
    • Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Identified in the spliceosome C complex. Interacts with HTATSF1.

neXtProt entry for SF3A2 Gene

Post-translational modifications for SF3A2 Gene

  • Ubiquitination at posLast=1010, posLast=4848, and isoforms=194

Other Protein References for SF3A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SF3A2 Gene

Domains & Families for SF3A2 Gene

Gene Families for SF3A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SF3A2 Gene

Suggested Antigen Peptide Sequences for SF3A2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15428

UniProtKB/Swiss-Prot:

SF3A2_HUMAN :
  • Belongs to the SF3A2 family.
Family:
  • Belongs to the SF3A2 family.
genes like me logo Genes that share domains with SF3A2: view

Function for SF3A2 Gene

Molecular function for SF3A2 Gene

UniProtKB/Swiss-Prot Function:
Subunit of the splicing factor SF3A required for A complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the E complex.

Phenotypes From GWAS Catalog for SF3A2 Gene

Gene Ontology (GO) - Molecular Function for SF3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA --
GO:0005515 protein binding IPI 17332742
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SF3A2: view
genes like me logo Genes that share phenotypes with SF3A2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SF3A2 Gene

Localization for SF3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SF3A2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SF3A2 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SF3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005686 U2 snRNP IBA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with SF3A2: view

Pathways & Interactions for SF3A2 Gene

genes like me logo Genes that share pathways with SF3A2: view

Pathways by source for SF3A2 Gene

1 KEGG pathway for SF3A2 Gene

Gene Ontology (GO) - Biological Process for SF3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000389 mRNA 3-splice site recognition TAS 15647371
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IMP 15647371
GO:0008380 RNA splicing TAS 8211113
GO:0010976 positive regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with SF3A2: view

No data available for SIGNOR curated interactions for SF3A2 Gene

Drugs & Compounds for SF3A2 Gene

(1) Drugs for SF3A2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202
genes like me logo Genes that share compounds with SF3A2: view

Transcripts for SF3A2 Gene

Unigene Clusters for SF3A2 Gene

Splicing factor 3a, subunit 2, 66kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SF3A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for SF3A2 Gene

GeneLoc Exon Structure for
SF3A2
ECgene alternative splicing isoforms for
SF3A2

Expression for SF3A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SF3A2 Gene

Protein differential expression in normal tissues from HIPED for SF3A2 Gene

This gene is overexpressed in Nasal epithelium (10.3), Bone (8.6), and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SF3A2 Gene



Protein tissue co-expression partners for SF3A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SF3A2 Gene:

SF3A2

SOURCE GeneReport for Unigene cluster for SF3A2 Gene:

Hs.115232

Evidence on tissue expression from TISSUES for SF3A2 Gene

  • Blood(4.2)
  • Lung(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with SF3A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SF3A2 Gene

Orthologs for SF3A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SF3A2 33 34
  • 99.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SF3A2 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SF3A2 34
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SF3A2 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sf3a2 34
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SF3A2 33 34
  • 87.83 (n)
chicken
(Gallus gallus)
Aves SF3A2 34
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sf3a2-prov 33
zebrafish
(Danio rerio)
Actinopterygii sf3a2 34
  • 87 (a)
OneToOne
zgc56097 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.198 33
fruit fly
(Drosophila melanogaster)
Insecta CG10754 35 34
  • 84 (a)
worm
(Caenorhabditis elegans)
Secernentea F11A10.2 35
  • 78 (a)
repo-1 34
  • 77 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP11 34 36
  • 27 (a)
OneToOne
barley
(Hordeum vulgare)
Liliopsida Hv.954 33
rice
(Oryza sativa)
Liliopsida Os.5848 33
wheat
(Triticum aestivum)
Liliopsida Ta.8406 33
corn
(Zea mays)
Liliopsida Zm.8991 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2750 34
  • 62 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2164 33
Species where no ortholog for SF3A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for SF3A2 Gene

ENSEMBL:
Gene Tree for SF3A2 (if available)
TreeFam:
Gene Tree for SF3A2 (if available)

Paralogs for SF3A2 Gene

Pseudogenes.org Pseudogenes for SF3A2 Gene

genes like me logo Genes that share paralogs with SF3A2: view

No data available for Paralogs for SF3A2 Gene

Variants for SF3A2 Gene

Sequence variations from dbSNP and Humsavar for SF3A2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000550001 -- 2,241,422(+) G/T intron_variant
rs1000622553 -- 2,238,022(+) G/C intron_variant
rs1000720009 -- 2,237,005(+) G/C intron_variant
rs1000948863 -- 2,247,231(+) G/A intron_variant
rs1000979992 -- 2,237,137(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SF3A2 Gene

Variant ID Type Subtype PubMed ID
dgv6218n54 CNV loss 21841781
esv1711865 CNV insertion 17803354
esv2717881 CNV deletion 23290073
nsv1110726 CNV insertion 24896259
nsv1125666 CNV tandem duplication 24896259
nsv2389 CNV insertion 18451855
nsv476713 CNV novel sequence insertion 20440878
nsv578382 CNV loss 21841781
nsv578383 CNV loss 21841781
nsv828396 CNV loss 20364138
nsv833706 CNV loss 17160897
nsv833707 CNV loss 17160897

Variation tolerance for SF3A2 Gene

Gene Damage Index Score: 1.21; 24.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SF3A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SF3A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SF3A2 Gene

Disorders for SF3A2 Gene

Additional Disease Information for SF3A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SF3A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SF3A2 Gene

Publications for SF3A2 Gene

  1. Correspondence between a mammalian spliceosome component and an essential yeast splicing factor. (PMID: 8211113) Bennett M … Reed R (Science (New York, N.Y.) 1993) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein. (PMID: 15142036) Takenaka K … Miki H (The Biochemical journal 2004) 3 22 58

Products for SF3A2 Gene

Sources for SF3A2 Gene

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