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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEZ6L2 Gene

protein-coding GIFtS: 51
GCID: GC16M029882

seizure related 6 homolog (mouse)-like 2

Explore 15 diseases affiliated with
SEZ6L2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Seizure Related 6 Homolog (Mouse)-Like 2¹ ²
PSK-1¹ ²
FLJ90517¹
Seizure 6-Like Protein 2²
Type I Transmembrane Receptor (Seizure-Related Protein)²
PSK³

External Ids:	HGNC: 30844¹	Entrez Gene: 26470²	Ensembl: ENSG00000174938⁷	UniProtKB: Q6UXD5³

Export aliases for SEZ6L2 gene to outside databases

Previous GC identifers: GC16M029789 GC16M027543

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEZ6L2:

This gene encodes a seizure-related protein that is localized on the cell surface. The gene is located in a region of

chromosome 16p11.2 that is thought to contain candidate genes for autism spectrum disorders (ASD), though there is no

evidence directly implicating this gene in ASD. Increased expression of this gene has been found in lung cancers, and

the protein is therefore considered to be a novel prognostic marker for lung cancer. Alternative splicing of this gene

results in multiple transcript variants. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: SE6L2_HUMAN, Q6UXD5

Function: May contribute to specialized endoplasmic reticulum functions in neurons (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEZ6L2 gene promoter:
RFX1 MAZR SREBP-1c Lmo2 SREBP-1b CP2 SREBP-1a HOXA5 c-Myb Zic3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SEZ6L2 promoter sequence

Search SABiosciences Chromatin IP Primers for SEZ6L2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEZ6L2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p12.1

SEZ6L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEZ6L2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M029882: view genomic region (about GC identifiers)

Start:	29,882,480 bp from pter	End:	29,910,868 bp from pter
Size:	28,389 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SE6L2_HUMAN, Q6UXD5 (See protein sequence)

Recommended Name: Seizure 6-like protein 2 precursor

Size: 910 amino acids; 97560 Da

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein (By similarity). Note=Detected on cell surface of lung-cancer

Miscellaneous: May serve as a prognostic marker for lung cancers

Secondary accessions: B7Z1N0 F5H293 H7BXQ6 Q9BW82 Q9UJ45 Q9UJ46 Q9UJ47

Alternative splicing: 6 isoforms: Q6UXD5-1 Q6UXD5-2 Q6UXD5-3 Q6UXD5-4 Q6UXD5-5 Q6UXD5-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEZ6L2: NX_Q6UXD5

Post-translational modifications:

O-glycosylated with core 1 or possibly core 8 glycans¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6UXD5

SEZ6L2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001107571.1 NP_001107572.1 NP_001230261.1 NP_001230262.1 NP_036542.1 NP_963869.2

ENSEMBL proteins:

ENSP00000319215 ENSP00000310206 ENSP00000312550 ENSP00000454654 ENSP00000458490

ENSP00000439412

Human Recombinant Protein Products for SEZ6L2:

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	Uscn Proteins for SEZ6L2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

SEZ6L2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SEZ6L2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEZ6L2 for domains About GeneDecksing

2 InterPro domains/families:

IPR000859 CUB_dom

IPR000436 Sushi_SCR_CCP

Graphical View of Domain Structure for InterPro Entry Q6UXD5

ProtoNet protein and cluster: Q6UXD5

2 Blocks protein families:

IPB000436 Sushi domain/SCR domain/CCP module

IPB000859 CUB domain

UniProtKB/Swiss-Prot: SE6L2_HUMAN, Q6UXD5

Similarity: Belongs to the SEZ6 family

Similarity: Contains 3 CUB domains

Similarity: Contains 5 Sushi (CCP/SCR) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SE6L2_HUMAN, Q6UXD5

Function: May contribute to specialized endoplasmic reticulum functions in neurons (By similarity)

Induction: Increased expression in the majority of primary lung cancers and lung-cell lines tested

Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sez6l2):

behavior/neurological

nervous system

normal

SEZ6L2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for SEZ6L2: Sez6l2^tm1Hta Sez6l2^tm1Lex

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SEZ6L2

miRNA Products:		OriGene 3'-UTR Clone (see all 4): SEZ6L2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEZ6L2
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate SEZ6L2 (see all 11):
		hsa-miR-299-5p hsa-miR-137 hsa-miR-196a* hsa-miR-1271 hsa-miR-29b-1* hsa-miR-373* hsa-miR-1253 hsa-miR-182

		SwitchGear 3'UTR luciferase reporter plasmid: SEZ6L2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEZ6L2 (see all 7) OriGene shRNA RFP: SEZ6L2 OriGene siRNA: SEZ6L2
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SEZ6L2
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEZ6L2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEZ6L2 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): SEZ6L2 (NM_001114099)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEZ6L2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEZ6L2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for SEZ6L2 (ENSP00000312550⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ETV5	ENSP00000306894⁴	STRING: ENSP00000306894
FOXA1	ENSP00000250448⁴	STRING: ENSP00000250448
OASL	ENSP00000257570⁴	STRING: ENSP00000257570
TK1	ENSP00000301634⁴	STRING: ENSP00000301634
UNG	ENSP00000242576⁴	STRING: ENSP00000242576

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SEZ6L2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEZ6L2
1 Novoseek chemical compound relationship for SEZ6L2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	0	1	14763144 (1)

Search CenterWatch for drugs/clinical trials and news about SEZ6L2 / SE6L2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEZ6L2 gene (6 alternative transcripts):

NM_001114099.2 NM_001114100.2 NM_001243332.1 NM_001243333.1 NM_012410.3 NM_201575.3

Unigene Cluster for SEZ6L2:

Seizure related 6 homolog (mouse)-like 2

Hs.6314 [show with all ESTs]

Unigene Representative Sequence: NM_001243332

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000346932 ENST00000350527 ENST00000308713(uc002dup.4 uc010vec.2 uc002dur.4 uc002duq.4 uc010ved.2 uc002dus.4)

ENST00000563118 ENST00000568407 ENST00000562159 ENST00000568380 ENST00000537485

miRNA Products:		OriGene 3'-UTR Clone (see all 4): SEZ6L2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEZ6L2
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate SEZ6L2 (see all 11):
		hsa-miR-299-5p hsa-miR-137 hsa-miR-196a* hsa-miR-1271 hsa-miR-29b-1* hsa-miR-373* hsa-miR-1253 hsa-miR-182

		SwitchGear 3'UTR luciferase reporter plasmid: SEZ6L2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEZ6L2 (see all 7) OriGene shRNA RFP: SEZ6L2 OriGene siRNA: SEZ6L2
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Additional cDNA sequence:

AF131749.1 AJ245820.1 AJ245822.1 AK027676.1 AK074998.1 AK293675.1 AK299103.1 AY358404.1

BC000567.2

19 DOTS entries:

DT.40261997 DT.100757029 DT.102841988 DT.40297021 DT.95371334 DT.120695212 DT.120696453 DT.120695756

DT.91830436 DT.100783439 DT.100783442 DT.95371332 DT.95371344 DT.100783441 DT.100783443 DT.95354175

DT.120695361 DT.120696712 DT.120697183

24/255 AceView cDNA sequences (see all 255):

Z99410 CB215429 CR622645 BQ953343 BM756096 CR619068 AA417872 AA632195

AI184600 CA454077 BC000567 AY358404 BQ639226 BM694287 BM757875 BQ576085

BX422736 AW004692 CK826238 AK027676 BQ549702 BM668886 BM699524 CA425885

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SEZ6L2 (see all 6) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	·	11c	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b
SP1:																			-
SP2:																			-																						-
SP3:									-		-								-
SP4:																			-				-
SP5:																							-

ECgene alternative splicing isoforms for SEZ6L2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEZ6L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCACCTGCT

About this image

SEZ6L2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Brain

Eye

Gut Tube

Neural Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

See SEZ6L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEZ6L2

SOURCE GeneReport for Unigene cluster: Hs.6314

SABiosciences Custom PCR Arrays for SEZ6L2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEZ6L2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SEZ6L2 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	SEZ6L2⁶	--	68(a)	1 ↔ 1	GL343279.1(5137-31014)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24635²	Xenopus laevis transcribed sequence with moderate similarity more	74.42(n)		CB180492.1
zebrafish (Danio rerio)	Actinopterygii	LOC557847¹	seizure protein 6 homolog	60.98(n) 57.5(a)		557847 XM_680990.3 XP_686082.3
worm (Caenorhabditis elegans)	Secernentea	T07H6.4⁶	Protein T07H6.4	7(a)	possible ortholog	X(6281881-6286136)

ENSEMBL Gene Tree for SEZ6L2 (if available)
TreeFam Gene Tree for SEZ6L2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEZ6L2 gene

CSMD1² SELP² C4BPA² CR2² SELL² CR1L² CSMD3² SEZ6²

SELE² SEZ6L² CSMD2² CR1² CD55² CD46² SVEP1²

3 SIMAP similar genes for SEZ6L2 using alignment to 3 protein entries: SE6L2_HUMAN (see all proteins):

SEZ6L SEZ6 CUBN

SEZ6L2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149149256^1,2	C	other	29891371(+)	`GCAGCG/AATCCT`	12	/R /C	mis¹		1		EU	703
rs139857443^1,2		--	29882209(+)	`TTCTCG/TCCCAT`	6	--	ds500¹		0	--	--	--	--
rs141561104^1,2		--	29882342(+)	`CCAGGC/TCCCCG`	6	--	ds500¹		0	--	--	--	--
rs200806898^1,2	C	--	29882402(-)	`GGGAAA/CAATTT`	6	--	ds500¹		0	--	--	--	--
rs187569399^1,2		--	29882459(+)	`CACCTC/TCCCAC`	6	--	ds500¹		0	--	--	--	--
rs78098570^1,2		--	29882472(+)	`TCCACC/TGGCCC`	6	--	ds500¹		1		WA	118
rs146189923^1,2		--	29882473(+)	`CCACCA/GGCCCA`	6	--	ds500¹		0	--	--	--	--
rs12917712^1,2	C,F,A,H	--	29882490(+)	`AGTGGC/TGATTT`	6	--	ut3¹		31		NS EA NA WA CSA	3197
rs73528395^1,2	C	--	29882543(+)	`AGAGAC/ATGTGG`	6	--	ut3¹		1		WA	2
rs138999626^1,2		--	29882668(+)	`CCTTCA/GTGGCC`	6	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SEZ6L2 (29882480 - 29910868 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SEZ6L2
2 CNVs: 35383 5820
Human Gene Mutation Database (HGMD): SEZ6L2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEZ6L2

DNA2.0 Custom Variant and Variant Library Synthesis for SEZ6L2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SEZ6L2 for disorders About GeneDecksing

15 diseases for SEZ6L2: About MalaCards

seizures autism spectrum disorder lung cancer systemic lupus erythematosus

lupus erythematosus adult t-cell leukemia leukemia/lymphoma folliculitis

seizure disorder t-cell leukemia lymphoblastic leukemia leukemia

alzheimer's disease colorectal cancer neuronitis

1 Novoseek disease relationship for SEZ6L2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	3	16863507 (2)

Human Genome Epidemiology (HuGE) Navigator: SEZ6L2 (3 documents)

Export disorders for SEZ6L2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SEZ6L2 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with SEZ6L2)

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The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
Characterization of SEZ6L2 cell-surface protein as a novel prognostic marker for lung cancer. (PubMed id 16863507)^{1, 2, 9} Ishikawa N....Nakamura Y. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Variations of the candidate SEZ6L2 gene on Chromosome 16p11.2 in patients with autism spectrum disorders and in human populations. (PubMed id 21394203)¹ Konyukh M....Bourgeron T. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Duplication 16p11.2 in a child with infantile seizure disorder. (PubMed id 20503337)¹ Bedoyan J.K....Martin D.M. (2010)
Enrichment of glycopeptides for glycan structure and attachment site identification. (PubMed id 19838169)² Nilsson J.... Larson G. (2009)
Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PubMed id 19260139)¹ Polasek O....Rudan I. (2009)
Association and mutation analyses of 16p11.2 autism candidate genes. (PubMed id 19242545)¹ Kumar R.A....Christian S.L. (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26470	HGNC: 30844	AceView: SEZ6L2	Ensembl:ENSG00000174938	euGenes: HUgn26470
ECgene: SEZ6L2	H-InvDB: SEZ6L2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SEZ6L2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SEZ6L2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SEZ6L2 gene
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Patent Information for SEZ6L2 gene:
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SEZ6L2 Gene

seizure related 6 homolog (mouse)-like 2

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SEZ6L2 Gene

seizure related 6 homolog (mouse)-like 2

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