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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEZ6L Gene

protein-coding GIFtS: 53
GCID: GC22P026565

seizure related 6 homolog (mouse)-like

(Previous name: seizure related gene 6 (mouse)-like )

Explore 7 diseases affiliated with
SEZ6L via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Seizure Related 6 Homolog (Mouse)-Like¹ ²
Seizure Related Gene 6 (Mouse)-Like¹
Seizure 6-Like Protein²
Seizure Related Gene 6-Like²
KIAA0927³

External Ids:	HGNC: 10763¹	Entrez Gene: 23544²	Ensembl: ENSG00000100095⁷	OMIM: 607021⁵	UniProtKB: Q9BYH1³

Export aliases for SEZ6L gene to outside databases

Previous GC identifers: GC22P023261 GC22P023384 GC22P024890 GC22P024889 GC22P009512

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SE6L1_HUMAN, Q9BYH1

Function: May contribute to specialized endoplasmic reticulum functions in neurons (By similarity)

Gene Wiki entry for SEZ6L

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEZ6L gene promoter:
ER-alpha SRF GATA-3 p53 SRF (504 AA) FOXD3 GATA-2 GATA-1 YY1 POU2F1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SEZ6L promoter sequence

Search SABiosciences Chromatin IP Primers for SEZ6L

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEZ6L

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1 Ensembl cytogenetic band: 22q12.1 HGNC cytogenetic band: 22q12.1

SEZ6L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEZ6L gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P026565: view genomic region (about GC identifiers)

Start:	26,565,440 bp from pter	End:	26,779,563 bp from pter
Size:	214,124 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SE6L1_HUMAN, Q9BYH1 (See protein sequence)

Recommended Name: Seizure 6-like protein precursor

Size: 1024 amino acids; 111782 Da

Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity)

Sequence caution: Sequence=BAA76771.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

1 PDB 3D structure from and Proteopedia for SEZ6L:

2YRA (3D)

Secondary accessions: A0AUW7 B0QYG4 B0QYG5 B7ZLJ6 G8JLP3 O95917 Q5THY5 Q6IBZ4 Q6UXD4 Q9NUI3 Q9NUI4

Q9NUI5 Q9Y2E1 Q9Y3J6

Alternative splicing: 7 isoforms: Q9BYH1-1 Q9BYH1-2 Q9BYH1-3 Q9BYH1-4 Q9BYH1-5 Q9BYH1-6 Q9BYH1-7 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEZ6L: NX_Q9BYH1

Post-translational modifications:

O-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BYH1

SEZ6L Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001171702.1 NP_001171703.1 NP_001171704.1 NP_001171705.1 NP_001171706.1 NP_066938.2

ENSEMBL proteins:

ENSP00000384772 ENSP00000354185 ENSP00000248933 ENSP00000342661 ENSP00000384838

ENSP00000384733 ENSP00000437037 ENSP00000397274

Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SEZ6L OriGene Protein Over-expression Lysate (see all 2): SEZ6L OriGene Custom Protein Services for SEZ6L
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	Novus Biologicals SEZ6L Protein Novus Biologicals SEZ6L Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SEZ6L

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

SEZ6L for ontologies About GeneDecksing

SEZ6L Antibody Products:

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	Uscn Antibodies for SEZ6L
	ThermoFisher Antibodies for SEZ6L

Assay Products for SEZ6L:

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	GenScript Custom Assay Services for SEZ6L
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	Uscn ELISAs and CLIAs for SEZ6L

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEZ6L for domains About GeneDecksing

2 InterPro domains/families:

IPR000859 CUB_dom

IPR000436 Sushi_SCR_CCP

Graphical View of Domain Structure for InterPro Entry Q9BYH1

ProtoNet protein and cluster: Q9BYH1

2 Blocks protein families:

IPB000436 Sushi domain/SCR domain/CCP module

IPB000859 CUB domain

UniProtKB/Swiss-Prot: SE6L1_HUMAN, Q9BYH1

Similarity: Belongs to the SEZ6 family

Similarity: Contains 3 CUB domains

Similarity: Contains 5 Sushi (CCP/SCR) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SE6L1_HUMAN, Q9BYH1

Function: May contribute to specialized endoplasmic reticulum functions in neurons (By similarity)

Genatlas biochemistry entry for SEZ6L:

seizure related gene 6 (mouse)-like

miRNA Products:		OriGene 3'-UTR Clone: SEZ6L Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEZ6L
		8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate SEZ6L (see all 77):
		hsa-miR-3607-3p hsa-miR-300 hsa-miR-30d hsa-miR-578 hsa-miR-374a hsa-miR-30a hsa-miR-3613-3p hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: SEZ6L 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEZ6L (see all 7) OriGene shRNA RFP: SEZ6L OriGene siRNA: SEZ6L
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEZ6L

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SEZ6L

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEZ6L (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEZ6L (see all 7) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): SEZ6L (NM_001184775)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEZ6L
		Search LifeMap BioReagents cell lines for SEZ6L

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEZ6L

Animal Models:
Mouse knock-outs for SEZ6L: Sez6l^tm1Hta Sez6l^tm1Lex
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sez6l):

behavior/neurological

nervous system

SEZ6L for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEZ6L

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEZ6L
Search CenterWatch for drugs/clinical trials and news about SEZ6L / SE6L1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEZ6L gene (6 alternative transcripts):

NM_001184773.1 NM_001184774.1 NM_001184775.1 NM_001184776.1 NM_001184777.1 NM_021115.4

Unigene Cluster for SEZ6L:

Seizure related 6 homolog (mouse)-like

Hs.194766 [show with all ESTs]

Unigene Representative Sequence: NM_021115

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000404234 ENST00000360929 ENST00000248933 ENST00000343706 ENST00000403121(uc010gvc.1)

ENST00000402979(uc003acf.1) ENST00000483291 ENST00000494013 ENST00000529632(uc003acb.3 uc011akc.2 uc003acc.3 uc003acd.3 uc011akd.2 uc003ace.3 uc011ake.2)

ENST00000411842

miRNA Products:		OriGene 3'-UTR Clone: SEZ6L Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEZ6L
		8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate SEZ6L (see all 77):
		hsa-miR-3607-3p hsa-miR-300 hsa-miR-30d hsa-miR-578 hsa-miR-374a hsa-miR-30a hsa-miR-3613-3p hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: SEZ6L 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEZ6L (see all 7) OriGene shRNA RFP: SEZ6L OriGene siRNA: SEZ6L
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEZ6L

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEZ6L (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEZ6L (see all 7) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): SEZ6L (NM_001184775)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEZ6L
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEZ6L

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEZ6L Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEZ6L
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEZ6L
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEZ6L

Additional cDNA sequence:

AB023144.2 AB041736.1 AK294790.1 AL050253.1 AY358405.1 BC037846.2 BC126115.1 BC143851.1

BC143854.1 CR456574.1

7 DOTS entries:

DT.111922 DT.97838043 DT.102829718 DT.75132234 DT.91644521 DT.40271865 DT.97769534

24/100 AceView cDNA sequences (see all 100):

BI962863 BE503273 BI962921 CR456574 BE220403 BE222339 H55462 BM875435

AI363908 BF591700 AI360299 AI015798 AB041736 AI365630 Z38680 AI281980

N46729 F05756 AI360241 BF062276 AY358405 NM_021115 CK300001 AL119766

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SEZ6L (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	·	12c	^	13	^	14	^	15	^	16	^	17a	·	17b	·	17c	^
SP1:									-																												-		-
SP2:									-																												-		-
SP3:																																					-		-
SP4:									-																								-		-		-		-				-
SP5:									-																												-		-		-		-

ExUns:	18a	·	18b	·	18c	·	18d
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SEZ6L

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEZ6L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGAGTCATT

About this image

SEZ6L expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Endoderm progenitor-like cells (Generation and expan...)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SEZ6L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEZ6L

SOURCE GeneReport for Unigene cluster: Hs.194766

UniProtKB/Swiss-Prot: SE6L1_HUMAN, Q9BYH1

Tissue specificity: Widely expressed, including adult and fetal brains and lungs. Not expressed in all lung cancer cell

lines

SABiosciences Custom PCR Arrays for SEZ6L

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEZ6L

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEZ6L

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SEZ6L gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SEZ6L¹	seizure related 6 homolog (mouse)-like	77.12(n) 79.84(a)		416906 XM_415197.3 XP_415197.3
zebrafish (Danio rerio)	Actinopterygii	LOC100331987¹	seizure 6-like protein-like	65.64(n) 66.58(a)		100331987 XM_002663663.2 XP_002663709.2
worm (Caenorhabditis elegans)	Secernentea	T07H6.4⁶	Protein T07H6.4	8(a)	possible ortholog	X(6281881-6286136)

ENSEMBL Gene Tree for SEZ6L (if available)
TreeFam Gene Tree for SEZ6L (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEZ6L gene

CSMD1² SEZ6L2² SELP² C4BPA² CR2² SELL² CR1L² CSMD3²

SEZ6² SELE² CSMD2² CR1² CD55² CD46² SVEP1²

6 SIMAP similar genes for SEZ6L using alignment to 5 protein entries: SE6L1_HUMAN (see all proteins):

SEZ6 SEZ6L2 CUBN CD55 CSMD1 CSMD2

SEZ6L for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182319947^1,2		--	26563618(+)	`GAGGGA/CGAGGA`	6	--	us2k¹		0	--	--	--	--
rs17371907^1,2	C,	--	26563800(+)	`TTCGTT/CTTTCT`	6	--	us2k¹ trp³		4		NA EA	262
rs115962274^1,2	F,	--	26564053(+)	`TTCTTT/CATAAA`	6	--	us2k¹		1		WA	118
rs117966464^1,2	C,F,	--	26564158(+)	`TCTGGG/TCCTAT`	6	--	us2k¹		1		NA	120
rs187538480^1,2		--	26564194(+)	`GTTTGA/CGTGAG`	6	--	us2k¹		0	--	--	--	--
rs146956616^1,2		--	26564572(+)	`CTGTCA/CCCAAG`	6	--	us2k¹		0	--	--	--	--
rs148008719^1,2		--	26564760(+)	`GCTAGA/TGCCCT`	6	--	us2k¹		0	--	--	--	--
rs141608479^1,2		--	26564768(+)	`CCTGCC/TGGCAG`	6	--	us2k¹		0	--	--	--	--
rs192937704^1,2		--	26564956(+)	`TAGGTG/TATGGG`	6	--	us2k¹		0	--	--	--	--
rs134755^1,2	C,F,H,	--	26565156(+)	`CCTGGC/TCTGGC`	6	--	us2k¹		18		NS EA NA CSA WA	2334

HapMap Linkage Disequilibrium report for SEZ6L (26565440 - 26779563 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SEZ6L
1 CNV: 2273

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEZ6L

DNA2.0 Custom Variant and Variant Library Synthesis for SEZ6L

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SEZ6L for disorders           About GeneDecksing

OMIM gene information: 607021    OMIM disorders: --

7 diseases for SEZ6L:    About MalaCards

seizures coronary heart disease nephropathy colorectal cancer

lung cancer atherosclerosis neuronitis

Human Genome Epidemiology (HuGE) Navigator: SEZ6L (8 documents)

Export disorders for SEZ6L gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SEZ6L gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with SEZ6L)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line. (PubMed id 11175339)^{1, 2, 9} Nishioka M....Yokota J. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)^{1, 2} Collins J.E.... Dunham I. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. (PubMed id 11992124)^{1, 2} Suzuki H.... Baylin S.B. (2002)
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{1, 2} Nagase T.... Ohara O. (1999)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Seizure 6-like (SEZ6L) gene and risk for lung cancer. (PubMed id 17804757)^{1, 9} Gorlov I.P....Amos C.I. (2007)
LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)² Halim A.... Nilsson J. (2013)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23544	HGNC: 10763	AceView: SEZ6L	Ensembl:ENSG00000100095	euGenes: HUgn23544
ECgene: SEZ6L	H-InvDB: SEZ6L

(According to HUGE)
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HUGE: KIAA0927

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SEZ6L	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEZ6L gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SEZ6L gene:
Search GeneIP for patents involving SEZ6L

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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SEZ6L Gene

seizure related 6 homolog (mouse)-like

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SEZ6L Gene

seizure related 6 homolog (mouse)-like

Aliasesfor SEZ6L gene

Summariesfor SEZ6L gene

Genomic Viewsfor SEZ6L gene

Proteinsfor SEZ6L gene

Protein Domains /Familiesfor SEZ6L gene

Functionfor SEZ6L gene

Pathways & Interactionsfor SEZ6L gene

Drugs & Compoundsfor SEZ6L gene

Transcriptsfor SEZ6L gene

Expression for SEZ6L gene

Orthologsfor SEZ6L gene

Paralogsfor SEZ6L gene

Genomic Variantsfor SEZ6L gene

Disorders / Diseasesfor SEZ6L gene

Publicationsfor SEZ6L gene

External Searches for SEZ6L gene

Genome Databases showing SEZ6L gene

Other Databases showing SEZ6L gene

Specialized Databases showing SEZ6L gene

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Productsfor SEZ6L gene

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Aliases
for SEZ6L gene

Summaries
for SEZ6L gene

Genomic Views
for SEZ6L gene

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for SEZ6L gene

Protein Domains /
Families
for SEZ6L gene

Function
for SEZ6L gene

Pathways & Interactions
for SEZ6L gene

Drugs & Compounds
for SEZ6L gene

Transcripts
for SEZ6L gene

Expression
for SEZ6L gene

Orthologs
for SEZ6L gene

Paralogs
for SEZ6L gene

Genomic Variants
for SEZ6L gene

Disorders / Diseases
for SEZ6L gene

Publications
for SEZ6L gene

Intellectual Property
for SEZ6L gene

Products
for SEZ6L gene