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SEZ6L Gene

protein-coding   GIFtS: 54
GCID: GC22P026565

Seizure Related 6 Homolog (Mouse)-Like

(Previous name: seizure related gene 6 (mouse)-like)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Seizure Related 6 Homolog (Mouse)-Like1 2
Seizure Related Gene 6 (Mouse)-Like1
Seizure 6-Like Protein2
Seizure Related Gene 6-Like2
KIAA09273

External Ids:    HGNC: 107631   Entrez Gene: 235442   Ensembl: ENSG000001000957   OMIM: 6070215   UniProtKB: Q9BYH13   

Export aliases for SEZ6L gene to outside databases

Previous GC identifers: GC22P023261 GC22P023384 GC22P024890 GC22P024889 GC22P009512


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SEZ6L Gene:
SEZ6L (seizure related 6 homolog (mouse)-like) is a protein-coding gene. Diseases associated with SEZ6L include diabetic nephropathy, and coronary heart disease. An important paralog of this gene is SEZ6L2.

UniProtKB/Swiss-Prot: SE6L1_HUMAN, Q9BYH1
Function: May contribute to specialized endoplasmic reticulum functions in neurons (By similarity)

Gene Wiki entry for SEZ6L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEZ6L gene promoter:
         ER-alpha   SRF   GATA-3   p53   SRF (504 AA)   FOXD3   GATA-2   GATA-1   YY1   POU2F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEZ6L promoter sequence
   Search Chromatin IP Primers for SEZ6L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEZ6L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1   Ensembl cytogenetic band:  22q12.1   HGNC cytogenetic band: 22q12.1

SEZ6L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEZ6L gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P026565:  view genomic region     (about GC identifiers)

Start:
26,565,440 bp from pter      End:
26,779,563 bp from pter
Size:
214,124 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SE6L1_HUMAN, Q9BYH1 (See protein sequence)
Recommended Name: Seizure 6-like protein precursor  
Size: 1024 amino acids; 111782 Da
Sequence caution: Sequence=BAA76771.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for SEZ6L:
2YRA (3D)    
Secondary accessions: A0AUW7 B0QYG4 B0QYG5 B7ZLJ6 G8JLP3 O95917 Q5THY5 Q6IBZ4 Q6UXD4 Q9NUI3
Q9NUI4 Q9NUI5 Q9Y2E1 Q9Y3J6
Alternative splicing: 7 isoforms:  Q9BYH1-1   Q9BYH1-2   Q9BYH1-3   Q9BYH1-4   Q9BYH1-5   Q9BYH1-6   Q9BYH1-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEZ6L: NX_Q9BYH1

Explore proteomics data for SEZ6L at MOPED

Post-translational modifications: 

  • O-glycosylated1
  • Glycosylation2 at Ser49, Asn311, Asn328, Asn350, Asn435, Asn458, Asn474, Asn514, Asn576, Asn618,
                                 Asn674, Asn742
  • Modification sites at PhosphoSitePlus

  • See SEZ6L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001171702.1  NP_001171703.1  NP_001171704.1  NP_001171705.1  NP_001171706.1  NP_066938.2  

    ENSEMBL proteins: 
     ENSP00000384772   ENSP00000354185   ENSP00000248933   ENSP00000342661   ENSP00000384838  
     ENSP00000384733   ENSP00000437037   ENSP00000397274  

    SEZ6L Human Recombinant Protein Products:

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    Novus Biologicals SEZ6L Protein
    Novus Biologicals SEZ6L Lysate
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    SEZ6L Assay Products:

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    Cloud-Clone Corp. CLIAs for SEZ6L


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000436 Sushi_SCR_CCP
     IPR000859 CUB_dom

    Graphical View of Domain Structure for InterPro Entry Q9BYH1

    ProtoNet protein and cluster: Q9BYH1

    2 Blocks protein domains:
    IPB000436 Sushi domain/SCR domain/CCP module
    IPB000859 CUB domain


    UniProtKB/Swiss-Prot: SE6L1_HUMAN, Q9BYH1
    Similarity: Belongs to the SEZ6 family
    Similarity: Contains 3 CUB domains
    Similarity: Contains 5 Sushi (CCP/SCR) domains


    SEZ6L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SE6L1_HUMAN, Q9BYH1
    Function: May contribute to specialized endoplasmic reticulum functions in neurons (By similarity)

         Genatlas biochemistry entry for SEZ6L:
    seizure related gene 6 (mouse)-like

    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sez6l):
     behavior/neurological  nervous system 

    SEZ6L for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SEZ6L: Sez6ltm1Hta Sez6ltm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEZ6L
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEZ6L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEZ6L

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SEZ6L (see all 77):
    hsa-miR-3607-3p hsa-miR-300 hsa-miR-30d hsa-miR-578 hsa-miR-374a hsa-miR-30a hsa-miR-3613-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSEZ6L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEZ6L
    Predesigned siRNA for gene silencing in human, mouse, rat SEZ6L

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 6): SEZ6L (NM_001184775)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEZ6L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEZ6L

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SEZ6L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEZ6L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SE6L1_HUMAN, Q9BYH1: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0043025neuronal cell body IEA--

    SEZ6L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEZ6L
    Interactions:

        Search GeneGlobe Interaction Network for SEZ6L

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SEZ6L (ENSP000002489334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNMT1ENSP000003525164STRING: ENSP00000352516
    EZH2ENSP000003201474STRING: ENSP00000320147
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008344adult locomotory behavior IEA--
    GO:0021680cerebellar Purkinje cell layer development IEA--
    GO:0060074synapse maturation IEA--
    GO:0090036regulation of protein kinase C signaling IEA--

    SEZ6L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEZ6L (SE6L1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SEZ6L gene (6 alternative transcripts): 
    NM_001184773.1  NM_001184774.1  NM_001184775.1  NM_001184776.1  NM_001184777.1  NM_021115.4  

    Unigene Cluster for SEZ6L:

    Seizure related 6 homolog (mouse)-like
    Hs.194766  [show with all ESTs]
    Unigene Representative Sequence: NM_021115
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404234 ENST00000360929 ENST00000248933 ENST00000343706 ENST00000403121(uc010gvc.1)
    ENST00000402979(uc003acf.1) ENST00000483291 ENST00000494013 ENST00000529632(uc003acb.3 uc011akc.2 uc003acc.3 uc003acd.3 uc011akd.2 uc003ace.3 uc011ake.2)
    ENST00000411842
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEZ6L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEZ6L (see all 77):
    hsa-miR-3607-3p hsa-miR-300 hsa-miR-30d hsa-miR-578 hsa-miR-374a hsa-miR-30a hsa-miR-3613-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSEZ6L 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SEZ6L
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): SEZ6L (NM_001184775)
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    Primer
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    OriGene qPCR primer pairs and template standards for SEZ6L
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEZ6L
      QuantiTect SYBR Green Assays in human, mouse, rat SEZ6L
      QuantiFast Probe-based Assays in human, mouse, rat SEZ6L

    Additional mRNA sequence: 

    AB023144.2 AB041736.1 AK294790.1 AL050253.1 AY358405.1 BC037846.2 BC126115.1 BC143851.1 
    BC143854.1 CR456574.1 

    7 DOTS entries:

    DT.111922  DT.97838043  DT.102829718  DT.75132234  DT.91644521  DT.40271865  DT.97769534 

    Selected AceView cDNA sequences (see all 100):

    BI962863 BI962921 BE503273 CR456574 BE222339 BE220403 H55462 BM875435 
    AI363908 BF591700 AI360299 AI015798 AB041736 AI281980 Z38680 AI365630 
    AY358405 N46729 F05756 AI360241 BF062276 NM_021115 AL119766 AI656870 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEZ6L (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^
    SP1:                          -                                                                                   -     -                                       
    SP2:                          -                                                                                   -     -                                       
    SP3:                                                                                                              -     -                                       
    SP4:                          -                                                                       -     -     -     -           -                           
    SP5:                          -                                                                                   -     -     -     -                           

    ExUns: 18a · 18b · 18c · 18d
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SEZ6L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEZ6L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGAGTCATT
    SEZ6L Expression
    About this image


    SEZ6L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Definitive endoderm-like cells
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
    SEZ6L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEZ6L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194766

    UniProtKB/Swiss-Prot: SE6L1_HUMAN, Q9BYH1
    Tissue specificity: Widely expressed, including adult and fetal brains and lungs. Not expressed in all lung cancer
    cell lines

        Custom PCR Arrays for SEZ6L
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    QuantiFast Probe-based Assays in human, mouse, rat SEZ6L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEZ6L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SEZ6L gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sez6l1 , 5 seizure related 6 homolog like1, 5 81.5(n)1
    85.03(a)1
      5 (54.72 cM)5
    567471  NM_001253916.11  NP_001240845.11 
     1124191515 
    chicken
    (Gallus gallus)
    Aves SEZ6L1 seizure related 6 homolog (mouse)-like 77.53(n)
    80.53(a)
      416906  XM_415197.4  XP_415197.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    26(a)
    many ↔ many
    GL343498.1(525521-556629)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sez6l1 seizure related 6 homolog (mouse)-like 69.33(n)
    75.33(a)
      100496825  XM_002932087.2  XP_002932133.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003319871 seizure 6-like protein-like 68.28(n)
    70.56(a)
      100331987  XM_005155435.1  XP_005155492.1 


    ENSEMBL Gene Tree for SEZ6L (if available)
    TreeFam Gene Tree for SEZ6L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEZ6L gene
    SEZ6L22  SEZ62  
    3 SIMAP similar genes for SEZ6L using alignment to 5 protein entries:     SE6L1_HUMAN (see all proteins):
    SEZ6    SEZ6L2    CUBN

    SEZ6L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEZ6L (see all 5068)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs711929051,2
    C--10520855(+) AAAAA-/A/GGAGGA 6 -- int11NA 2
    rs1823199471,2
    --26563618(+) GAGGGA/CGAGGA 6 -- us2k10--------
    rs3677510041,2
    C--26563733(+) CAAGTA/TCCCTG 6 -- us2k10--------
    rs173719071,2
    C,F--26563800(+) TTCGTT/CTTTCT 6 -- us2k1 trp34Minor allele frequency- C:0.01NA EA 262
    rs1159622741,2
    F--26564053(+) TTCTTT/CATAAA 6 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1179664641,2
    C,F--26564158(+) TCTGGG/TCCTAT 6 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1875384801,2
    --26564194(+) GTTTGA/CGTGAG 6 -- us2k10--------
    rs1469566161,2
    C--26564572(+) CTGTCA/CCCAAG 6 -- us2k10--------
    rs1480087191,2
    --26564760(+) GCTAGA/TGCCCT 6 -- us2k10--------
    rs1416084791,2
    C--26564768(+) CCTGCC/TGGCAG 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for SEZ6L (26565440 - 26779563 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SEZ6L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1931124CNV Deletion18987734
    nsv3582CNV Insertion18451855
    nsv829136CNV Loss20364138
    nsv469709CNV Loss16826518
    nsv3583CNV Loss18451855
    nsv829137CNV Loss20364138
    nsv834165CNV Gain+Loss17160897
    nsv7350OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEZ6L
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 607021    OMIM disorders: --

    8 diseases for SEZ6L:    
    About MalaCards
    diabetic nephropathy    coronary heart disease    coronary artery disease    insulin resistance
    atherosclerosis    lung cancer    colorectal cancer    neuronitis


    SEZ6L for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEZ6L
    Human Genome Epidemiology (HuGE) Navigator: SEZ6L (8 documents)

    Export disorders for SEZ6L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SEZ6L gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with SEZ6L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line. (PubMed id 11175339)1, 2, 9 Nishioka M....Yokota J. (Oncogene 2000)
    2. Seizure 6-like (SEZ6L) gene and risk for lung cancer. (PubMed id 17804757)1, 4, 9 Gorlov I.P....Amos C.I. (Cancer Res. 2007)
    3. Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study. (PubMed id 21901158)1, 4 Irvin M.R....Arnett D.K. (PLoS ONE 2011)
    4. Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study. (PubMed id 19955471)1, 4 Bressler J....Boerwinkle E. (Am. J. Epidemiol. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Incorporation of a genetic factor into an epidemiologic model for prediction of individual risk of lung cancer: the Liverpool Lung Project. (PubMed id 20424129)1, 4 Raji O.Y....Field J.K. (Cancer Prev Res (Phila) 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Genetic analysis of coronary artery disease single-nucleotide polymorphisms in diabetic nephropathy. (PubMed id 19336575)1, 4 McKnight A.J....Savage D.A. (Nephrol. Dial. Transplant. 2009)
    9. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1, 4 (Nature 2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 23544 HGNC: 10763 AceView: SEZ6L Ensembl:ENSG00000100095 euGenes: HUgn23544
    ECgene: SEZ6L H-InvDB: SEZ6L

    (According to HUGE)
    About This Section

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    HUGE: KIAA0927

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SEZ6L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SEZ6L gene:
    Search GeneIP for patents involving SEZ6L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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