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Aliases for SETSIP Gene

Aliases for SETSIP Gene

  • SET-Like Protein 2 3
  • SET Similar Protein 2 3 4
  • SET Pseudogene Protein 18 3 4
  • SET Pseudogene 18 2 3
  • SETP18 3 4
  • Similar To SET Translocation Protein 4
  • SET Nuclear Oncogene Pseudogene 3
  • Protein SETSIP 3

External Ids for SETSIP Gene

Previous HGNC Symbols for SETSIP Gene

  • SETP18

Previous GeneCards Identifiers for SETSIP Gene

  • GC01M092543

Summaries for SETSIP Gene

GeneCards Summary for SETSIP Gene

SETSIP (SET-Like Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SETSIP Gene

  • Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SETSIP Gene

Genomics for SETSIP Gene

Genomic Location for SETSIP Gene

Start:
92,074,436 bp from pter
End:
92,075,472 bp from pter
Size:
1,037 bases
Orientation:
Minus strand

Genomic View for SETSIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SETSIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SETSIP Gene

No data available for Regulatory Elements for SETSIP Gene

Proteins for SETSIP Gene

  • Protein details for SETSIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DME0-SETLP_HUMAN
    Recommended name:
    Protein SETSIP
    Protein Accession:
    P0DME0
    Secondary Accessions:

    Protein attributes for SETSIP Gene

    Size:
    302 amino acids
    Molecular mass:
    34882 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Probable retrogene derived from SET transcript

neXtProt entry for SETSIP Gene

Proteomics data for SETSIP Gene at MOPED

Post-translational modifications for SETSIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SETSIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SETSIP Gene

Domains for SETSIP Gene

Protein Domains for SETSIP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0DME0

UniProtKB/Swiss-Prot:

SETLP_HUMAN :
  • P0DME0
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with SETSIP: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SETSIP Gene

Function for SETSIP Gene

Molecular function for SETSIP Gene

UniProtKB/Swiss-Prot Function: Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter.
UniProtKB/Swiss-Prot Induction: Up-regulated during protein-induced pluripotent stem (PiPS) endothelial cell differention. Up-regulated by VEGFA and POU2F1 (at protein level).

Gene Ontology (GO) - Molecular Function for SETSIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 22869753
genes like me logo Genes that share ontologies with SETSIP: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SETSIP Gene

Localization for SETSIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SETSIP Gene

Cytoplasm. Nucleus. Note=Translocated from the cytoplasm to the nucleus in protein-induced pluripotent stem (PiPS) endothelial cells.

Gene Ontology (GO) - Cellular Components for SETSIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22869753
GO:0005737 cytoplasm IDA 22869753
genes like me logo Genes that share ontologies with SETSIP: view

No data available for Subcellular locations from COMPARTMENTS for SETSIP Gene

Pathways for SETSIP Gene

SuperPathways for SETSIP Gene

No Data Available

Interacting Proteins for SETSIP Gene

Gene Ontology (GO) - Biological Process for SETSIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0045446 endothelial cell differentiation IDA 22869753
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 22869753
genes like me logo Genes that share ontologies with SETSIP: view

No data available for Pathways by source for SETSIP Gene

Transcripts for SETSIP Gene

mRNA/cDNA for SETSIP Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SETSIP Gene

No ASD Table

Relevant External Links for SETSIP Gene

GeneLoc Exon Structure for
SETSIP
ECgene alternative splicing isoforms for
SETSIP

Expression for SETSIP Gene

mRNA expression in normal human tissues for SETSIP Gene

mRNA differential expression in normal tissues according to GTEx for SETSIP Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.7).

mRNA Expression by UniProt/SwissProt for SETSIP Gene

P0DME0-SETLP_HUMAN
Tissue specificity: Expressed in endothelial cell (EC) and protein-induced pluripotent stem (PiPS) endothelial cell (EC) (at protein level).
genes like me logo Genes that share expressions with SETSIP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for SETSIP Gene

Orthologs for SETSIP Gene

This gene was present in the common ancestor of mammals.

Orthologs for SETSIP Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC403555 35
  • 89.5 (n)
  • 84.68 (a)
mouse
(Mus musculus)
Mammalia BC085271 16
rat
(Rattus norvegicus)
Mammalia Setl1 35
  • 87.34 (n)
  • 82.7 (a)
Species with no ortholog for SETSIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SETSIP Gene

ENSEMBL:
Gene Tree for SETSIP (if available)
TreeFam:
Gene Tree for SETSIP (if available)

Paralogs for SETSIP Gene

No data available for Paralogs for SETSIP Gene

Variants for SETSIP Gene

Sequence variations from dbSNP and Humsavar for SETSIP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12744052 -- 92,074,512(+) GAAGG(G/T)TGGAG utr-variant-3-prime
rs34594180 -- 92,074,260(+) CTTTT(-/T)CCCCA downstream-variant-500B
rs35336097 -- 92,076,087(+) GGCAT(-/T)GGTGG upstream-variant-2KB
rs35615991 -- 92,076,988(+) ATTAA(-/G)GGGAT upstream-variant-2KB
rs55828025 -- 92,074,734(+) TTTGG(C/T)CAAAT stop-gained, reference

Relevant External Links for SETSIP Gene

HapMap Linkage Disequilibrium report
SETSIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SETSIP Gene

Disorders for SETSIP Gene

No disorders were found for SETSIP Gene.

No data available for UniProtKB/Swiss-Prot for SETSIP Gene

Publications for SETSIP Gene

  1. Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels. (PMID: 22869753) Margariti A. … Xu Q. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  3. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. (PMID: 22354994) Teachenor R. … Murre C. (Mol. Cell. Biol. 2012) 3
  4. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3

Products for SETSIP Gene

Sources for SETSIP Gene

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