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SETMAR Gene

protein-coding   GIFtS: 59
GCID: GC03P004344

SET Domain And Mariner Transposase Fusion Gene

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SET Domain And Mariner Transposase Fusion Gene1 2     Mar12
HsMar12 3     Histone-Lysine N-Methyltransferase SETMAR2
SET Domain And Mariner Transposase Fusion Gene-Containing Protein2 3     Metnase3
METNASE2 5     EC 2.1.1.438

External Ids:    HGNC: 107621   Entrez Gene: 64192   Ensembl: ENSG000001703647   OMIM: 6098345   UniProtKB: Q53H473   

Export aliases for SETMAR gene to outside databases

Previous GC identifers: GC03P004273 GC03P004336 GC03P004320


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SETMAR Gene:
This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a
C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities
including non-homologous end joining and double strand break repair. The SET domain portion of this protein
specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid
primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, Jan 2013)

GeneCards Summary for SETMAR Gene:
SETMAR (SET domain and mariner transposase fusion gene) is a protein-coding gene. GO annotations related to this gene include protein homodimerization activity and histone-lysine N-methyltransferase activity. An important paralog of this gene is NSD1.

UniProtKB/Swiss-Prot: SETMR_HUMAN, Q53H47
Function: Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for
epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific
DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1
element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of
foreign DNA

Gene Wiki entry for SETMAR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SETMAR gene promoter:
         TBP   LHX3b/Lhx3b   MyoD   LHX3a/Lhx3a   AP-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSETMAR promoter sequence
   Search Chromatin IP Primers for SETMAR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SETMAR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p26.1   Ensembl cytogenetic band:  3p26.1   HGNC cytogenetic band: 3p26.2

SETMAR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETMAR gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P004344:  view genomic region     (about GC identifiers)

Start:
4,344,988 bp from pter      End:
4,359,251 bp from pter
Size:
14,264 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SETMR_HUMAN, Q53H47 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SETMAR  
Size: 671 amino acids; 76669 Da
Cofactor: Binds 1 magnesium ion per subunit
Miscellaneous: The mariner transposase region in only present in primates and appeared 40-58 million years ago,
after the insertion of a transposon downstream of a preexisting SET gene, followed by the de novo exonization of
previously non-coding sequence and the creation of a new intron
4 PDB 3D structures from and Proteopedia for SETMAR:
3BO5 (3D)        3F2K (3D)        3K9J (3D)        3K9K (3D)    
Secondary accessions: Q13579 Q1G668 Q96F41
Alternative splicing: 2 isoforms:  Q53H47-1   Q53H47-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SETMAR: NX_Q53H47

Explore proteomics data for SETMAR at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for SETMAR (Q53H47)
     NHSCEPN  PFQYTPDHV 


    See SETMAR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230652.1  NP_001263254.1  NP_006506.3  

    ENSEMBL proteins: 
     ENSP00000373354   ENSP00000393044   ENSP00000397463   ENSP00000403000   ENSP00000403145  
     ENSP00000369673  

    SETMAR Human Recombinant Protein Products:

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    Novus Biologicals SETMAR Protein
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    Cloud-Clone Corp. Proteins for SETMAR

     
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    antibodies-online proteins for SETMAR (4 products) 

     
    antibodies-online peptides for SETMAR

    SETMAR Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SETMAR
    antibodies-online antibodies for SETMAR (19 products) 

    SETMAR Assay Products:

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    Cloud-Clone Corp. ELISAs for SETMAR
    Cloud-Clone Corp. CLIAs for SETMAR
    Search eBioscience for ELISAs for SETMAR 
    antibodies-online kits for SETMAR (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR001214 SET_dom
     IPR003616 Post-SET_dom
     IPR003606 Pre-SET_Zn-bd_sub
     IPR001888 Transposase_1
     IPR002492 Transposase_Tc1-like

    Graphical View of Domain Structure for InterPro Entry Q53H47

    ProtoNet protein and cluster: Q53H47

    2 Blocks protein domains:
    IPB001214 Nuclear protein SET
    IPB003616 SET-related region


    UniProtKB/Swiss-Prot: SETMR_HUMAN, Q53H47
    Domain: The mariner transposase Hsmar1 region mediates DNA-binding. It has no transposase activity because the
    active site contains an Asn in position 610 instead of a Asp residue
    Similarity: In the N-terminal section; belongs to the class V-like SAM-binding methyltransferase superfamily
    Similarity: In the C-terminal section; belongs to the mariner transposase family
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 pre-SET domain
    Similarity: Contains 1 SET domain


    Find genes that share domains with SETMAR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SETMR_HUMAN, Q53H47
    Function: Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for
    epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific
    DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1
    element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of
    foreign DNA
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Number (IUBMB): EC 2.1.1.432

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0004519endonuclease activity IDA--
    GO:0004803transposase activity TAS--
    GO:0005515protein binding IPI19390626
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with SETMAR           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for SETMAR:
     Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SETMAR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SETMAR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SETMAR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SETMAR

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    GenScript: all cDNA clones in your preferred vector: SETMAR (NM_006515)
    Sino Biological Human cDNA Clone for SETMAR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETMAR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETMAR
    Addgene plasmids for SETMAR 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETMAR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SETMR_HUMAN, Q53H47: Nucleus (Probable). Chromosome (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    plasma membrane2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC--
    GO:0005694chromosome IEA--

    Find genes that share ontologies with SETMAR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SETMAR About    
    See pathways by source

    SuperPathContained pathways About
    1Lysine degradation
    Lysine degradation


    Find genes that share SuperPaths with SETMAR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for SETMAR):
        Lysine degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SETMAR
    Interactions:

        Search GeneGlobe Interaction Network for SETMAR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for SETMAR (Q53H473 ENSP000003733544) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120043, ENSP000003684384I2D: score=1 STRING: ENSP00000368438
    RAD9AQ996383, ENSP000003113604I2D: score=1 STRING: ENSP00000311360
    TOP2AP113883, ENSP000004115324I2D: score=1 STRING: ENSP00000411532
    PRPF19Q9UMS43, ENSP000002275244I2D: score=1 STRING: ENSP00000227524
    XRCC4Q134263, ENSP000003420114I2D: score=1 STRING: ENSP00000342011
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000729DNA double-strand break processing IDA--
    GO:0000737DNA catabolic process, endonucleolytic IDA--
    GO:0006313transposition, DNA-mediated TAS9461395
    GO:0015074DNA integration IEA--
    GO:0034968histone lysine methylation ----

    Find genes that share ontologies with SETMAR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SETMAR (SETMR)

    2 HMDB Compounds for SETMAR    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SETMAR gene (3 alternative transcripts): 
    NM_001243723.1  NM_001276325.1  NM_006515.3  

    Unigene Cluster for SETMAR:

    SET domain and mariner transposase fusion gene
    Hs.475300  [show with all ESTs]
    Unigene Representative Sequence: AK122967
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358065(uc011asp.2 uc011asq.2 uc003bpy.4 uc011asr.2 uc010hbx.3)
    ENST00000413809 ENST00000425046 ENST00000430981(uc003bpw.4) ENST00000425863
    ENST00000358950 ENST00000490691 ENST00000462115
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SETMAR
    Clone
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    GenScript: all cDNA clones in your preferred vector: SETMAR (NM_006515)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETMAR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETMAR
    Addgene plasmids for SETMAR 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SETMAR
      QuantiTect SYBR Green Assays in human, mouse, rat SETMAR
      QuantiFast Probe-based Assays in human, mouse, rat SETMAR

    Additional mRNA sequence: 

    AF054989.1 AK122967.1 AK222734.1 AK297865.1 AK302296.1 AK307537.1 AK311418.1 AY952295.1 
    BC008931.2 BC011635.2 NR_024022.1 NR_075073.1 U80776.1 

    9 DOTS entries:

    DT.408364  DT.203631  DT.120874334  DT.91657404  DT.100692925  DT.95078066  DT.102842711  DT.100802930 
    DT.434190 

    Selected AceView cDNA sequences (see all 81):

    AA972798 T16607 BM677483 BX388110 AA236558 BU164805 CR600492 CD367822 
    BQ650846 AL515729 AW583590 BC011635 AA234618 CD366647 BQ651111 BX451998 
    CA313648 BM723028 BP377589 W93323 BC008931 AF054989 BE890511 BX451999 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SETMAR (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d
    SP1:                    -     -     -                       -                                             
    SP2:                    -     -     -     -     -     -                       -                           
    SP3:                    -     -     -                                         -                           
    SP4:                                -     -     -     -                       -                           
    SP5:                    -     -     -                                                                     


    ECgene alternative splicing isoforms for SETMAR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SETMAR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCACAACC
    SETMAR Expression
    About this image

    SETMAR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SETMAR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.475300

    UniProtKB/Swiss-Prot: SETMR_HUMAN, Q53H47
    Tissue specificity: Widely expressed, with highest expression in placenta and ovary and lowest expression in
    skeletal muscle

        Custom PCR Arrays for SETMAR
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETMAR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SETMAR gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1017476821 histone-lysine N-methyltransferase SETMAR-like 64.66(n)
    67.84(a)
      101747682  XM_004944733.1  XP_004944790.1 
    lizard
    (Anolis carolinensis)
    Reptilia SETMAR6
    SET domain and mariner transposase fusion gene
    62(a)
    1 ↔ 1
    2(173660193-173660990)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia setmar1 SET domain and mariner transposase fusion gene 59.26(n)
    53.33(a)
      100135741  NM_001114263.1  NP_001107735.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AL919348.12   -- 75.35(n)    AL919348.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG45651 CG4565 54.36(n)
    46.59(a)
      41303  NM_001104273.2  NP_001097743.1 
            Species with no ortholog for SETMAR

    ENSEMBL Gene Tree for SETMAR (if available)
    TreeFam Gene Tree for SETMAR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SETMAR gene
    NSD12  ASH1L2  WHSC12  WHSC1L12  SUV39H22  SETBP12  SETDB22  SUV39H12  
    SETD22  EHMT12  EHMT22  SETDB12  
    3 SIMAP similar genes for SETMAR using alignment to 7 protein entries:     SETMR_HUMAN (see all proteins):
    BCL7C    FP13812    EHMT1

    Find genes that share paralogs with SETMAR           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SETMAR
    PGOHUM00000247563


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SETMAR (see all 462)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1499448241,2
    C--4343005(+) CAGCAA/GAAGAG 4 -- us2k10--------
    rs1922995711,2
    --4343008(+) CAAAAC/GAGACC 4 -- us2k10--------
    rs738069911,2
    C,F--4343117(+) AAATAT/CAATAA 4 -- us2k13Minor allele frequency- C:0.21WA CSA 121
    rs1441386561,2
    --4343156(+) AGCAGC/TGGCAG 4 -- us2k10--------
    rs1485185041,2
    --4343157(+) GCAGCA/GGCAGT 4 -- us2k10--------
    rs1453417341,2
    C--4343158(+) CAGCGA/GCAGTA 4 -- us2k10--------
    rs763729211,2
    --4343161(+) CGGCAG/TTAAGG 4 -- us2k10--------
    rs124957991,2
    H--4343338(+) GTGAAA/GGAATA 5 -- us2k10--------
    rs1132536961,2
    F--4343352(+) AGTAAC/TTGGTT 5 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1448377371,2
    C--4343374(+) TGGCTC/TTGTAG 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for SETMAR (4344988 - 4359251 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SETMAR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876463CNV Loss21882294
    nsv469899CNV Loss18288195
    nsv876429CNV Loss21882294
    nsv876462CNV Loss21882294
    dgv272n21CNV Loss19592680
    nsv876461CNV Gain21882294
    dgv1431e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609834    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SETMAR:
    Situs inversus

    Find genes that share disorders with SETMAR           About GenesLikeMe

    Genetic Association Database (GAD): SETMAR
    Human Genome Epidemiology (HuGE) Navigator: SETMAR (1 document)

    Export disorders for SETMAR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SETMAR gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with SETMAR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular evolution of an ancient mariner transposon, Hsmar1, in the human genome. (PubMed id 9461395)1, 2, 3 Robertson H.M. and Zumpano K.L. (Gene 1997)
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    3. Biochemical characterization of a SET and transposase fusion protein, Metnase: its DNA binding and DNA cleavage activity. (PubMed id 17877369)1, 2 Roman Y.... Lee S.H. (Biochemistry 2007)
    4. The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends. (PubMed id 17403897)1, 2 Miskey C....Ivics Z. (Mol. Cell. Biol. 2007)
    5. Birth of a chimeric primate gene by capture of the transposase gene from a mobile element. (PubMed id 16672366)1, 2 Cordaux R.... Feschotte C. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    6. The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair. (PubMed id 16332963)1, 2 Lee S.-H.... Hromas R. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    9. Genome-wide association study of chronic periodontitis in a general German population. (PubMed id 24024966)1 Teumer A....Kocher T. (J. Clin. Periodontol. 2013)
    10. Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart. (PubMed id 22231448)1 Hromas R....Lee S.H. (Oncogene 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6419 HGNC: 10762 AceView: SETMAR Ensembl:ENSG00000170364 euGenes: HUgn6419
    ECgene: SETMAR Kegg: 6419 H-InvDB: SETMAR

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SETMAR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SETMAR gene:
    Search GeneIP for patents involving SETMAR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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