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Aliases for SETMAR Gene

Aliases for SETMAR Gene

  • SET Domain And Mariner Transposase Fusion Gene 2 3 5
  • SET Domain And Mariner Transposase Fusion Protein 3 4
  • METNASE 3 4
  • SET Domain And Mariner Transposase Fusion Gene-Containing Protein 3
  • Histone-Lysine N-Methyltransferase SETMAR 3
  • EC 2.1.1.43 61
  • Mar1 3

External Ids for SETMAR Gene

Previous GeneCards Identifiers for SETMAR Gene

  • GC03P004273
  • GC03P004336
  • GC03P004320
  • GC03P004344

Summaries for SETMAR Gene

Entrez Gene Summary for SETMAR Gene

  • This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for SETMAR Gene

SETMAR (SET Domain And Mariner Transposase Fusion Gene) is a Protein Coding gene. Diseases associated with SETMAR include Mantle Cell Lymphoma. Among its related pathways are PKMTs methylate histone lysines and Lysine degradation. GO annotations related to this gene include protein homodimerization activity and single-stranded DNA binding. An important paralog of this gene is SETD2.

UniProtKB/Swiss-Prot for SETMAR Gene

  • Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates Lys-4 and Lys-36 of histone H3. Specifically mediates dimethylation of H3 Lys-36 at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750).

Gene Wiki entry for SETMAR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SETMAR Gene

Genomics for SETMAR Gene

Regulatory Elements for SETMAR Gene

Enhancers for SETMAR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F004491 1.1 ENCODE 22.7 +190.9 190857 5.0 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SETMAR SUMF1 ITPR1 EDEM1 LOC105376933
GH03F004302 0.2 ENCODE 18.6 +0.4 352 1.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF207 ZNF143 SETMAR SUMF1 PIR41698 PIR40718 GC03P004319
GH03F004466 0.7 ENCODE 13.7 +163.8 163788 1.5 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SETMAR SUMF1 EDEM1 ITPR1 MRPS10P2
GH03F005121 0.2 ENCODE 13.6 +820.2 820175 3.7 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 EDEM1 SETMAR ARL8B ENSG00000233912
GH03F004905 1 Ensembl ENCODE 12.5 +602.8 602832 1.7 PKNOX1 ZFP64 INSM2 FEZF1 ZNF680 ZNF654 ZBTB11 OVOL3 CEBPB ZNF645 UBTFL8 ENSG00000230944 SETMAR ITPR1-AS1 EDEM1 BHLHE40-AS1 ENSG00000235978 GC03M004976
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SETMAR on UCSC Golden Path with GeneCards custom track

Promoters for SETMAR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001476101 497 2000 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF207 ZNF143

Genomic Location for SETMAR Gene

Chromosome:
3
Start:
4,303,304 bp from pter
End:
4,317,567 bp from pter
Size:
14,264 bases
Orientation:
Plus strand

Genomic View for SETMAR Gene

Genes around SETMAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SETMAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SETMAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SETMAR Gene

Proteins for SETMAR Gene

  • Protein details for SETMAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53H47-SETMR_HUMAN
    Recommended name:
    Histone-lysine N-methyltransferase SETMAR
    Protein Accession:
    Q53H47
    Secondary Accessions:
    • B4DY74
    • E7EN68
    • Q13579
    • Q1G668
    • Q96F41

    Protein attributes for SETMAR Gene

    Size:
    684 amino acids
    Molecular mass:
    78034 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer (PubMed:20521842). Interacts with PRPF19; required for SETMAR recruitment to damaged DNA sites (PubMed:18263876). Interacts with PCNA (PubMed:20457750). Interacts with TOP2A; stimulates TOP2A topoisomerase activity (PubMed:18790802, PubMed:20457750). May interact with RAD9A and/or RAD9B (PubMed:20457750).
    Miscellaneous:
    • The mariner transposase region in only present in primates and appeared 40-58 million years ago, after the insertion of a transposon downstream of a preexisting SET gene, followed by the de novo exonization of previously non-coding sequence and the creation of a new intron.
    SequenceCaution:
    • Sequence=AAH11635.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAY29570.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96454.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SETMAR Gene

    Alternative splice isoforms for SETMAR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SETMAR Gene

Selected DME Specific Peptides for SETMAR Gene

Q53H47:
  • NHSCEPN
  • PFQYTPDHV

Post-translational modifications for SETMAR Gene

  • Methylated. Methylation regulates activity in DNA decatenation.
  • Phosphorylated at Ser-508 by CHEK1 and dephosphorylated by protein phosphatase 2A/PP2A. Phosphorylation at Ser-508 is enhanced by DNA damage and promotes recruitment to damaged DNA. It stimulates DNA repair and impairs replication fork restart.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for SETMAR
  • Santa Cruz Biotechnology (SCBT) Antibodies for SETMAR

Domains & Families for SETMAR Gene

Protein Domains for SETMAR Gene

Suggested Antigen Peptide Sequences for SETMAR Gene

Graphical View of Domain Structure for InterPro Entry

Q53H47

UniProtKB/Swiss-Prot:

SETMR_HUMAN :
  • The mariner transposase Hsmar1 region mediates DNA-binding. It has retained some of the nucleases activity but has lost its transposase activity because the active site contains an Asn in position 610 instead of an Asp residue.
  • In the N-terminal section; belongs to the class V-like SAM-binding methyltransferase superfamily.
Domain:
  • The mariner transposase Hsmar1 region mediates DNA-binding. It has retained some of the nucleases activity but has lost its transposase activity because the active site contains an Asn in position 610 instead of an Asp residue.
  • In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
  • Contains 1 post-SET domain.
  • Contains 1 pre-SET domain.
  • Contains 1 SET domain.
Family:
  • In the N-terminal section; belongs to the class V-like SAM-binding methyltransferase superfamily.
  • In the C-terminal section; belongs to the mariner transposase family.
genes like me logo Genes that share domains with SETMAR: view

No data available for Gene Families for SETMAR Gene

Function for SETMAR Gene

Molecular function for SETMAR Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
UniProtKB/Swiss-Prot Function:
Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates Lys-4 and Lys-36 of histone H3. Specifically mediates dimethylation of H3 Lys-36 at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750).

Enzyme Numbers (IUBMB) for SETMAR Gene

Gene Ontology (GO) - Molecular Function for SETMAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000014 single-stranded DNA endodeoxyribonuclease activity IMP 24573677
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding IMP 24573677
GO:0003697 single-stranded DNA binding IMP 24573677
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with SETMAR: view
genes like me logo Genes that share phenotypes with SETMAR: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SETMAR Gene

Localization for SETMAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for SETMAR Gene

Nucleus. Chromosome. Note=Recruited on damaged DNA at sites of double-strand breaks. {ECO:0000269 PubMed:18263876}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SETMAR Gene COMPARTMENTS Subcellular localization image for SETMAR gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SETMAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000793 colocalizes_with condensed chromosome IDA 18790802
GO:0005634 nucleus IDA 22231448
GO:0005694 chromosome IEA --
GO:0035861 site of double-strand break IMP 22231448
genes like me logo Genes that share ontologies with SETMAR: view

Pathways & Interactions for SETMAR Gene

genes like me logo Genes that share pathways with SETMAR: view

Pathways by source for SETMAR Gene

1 BioSystems pathway for SETMAR Gene
1 KEGG pathway for SETMAR Gene

Gene Ontology (GO) - Biological Process for SETMAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000729 DNA double-strand break processing IDA 21491884
GO:0000737 DNA catabolic process, endonucleolytic IMP 24573677
GO:0006281 DNA repair IEA --
GO:0006303 double-strand break repair via nonhomologous end joining IMP 18263876
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with SETMAR: view

No data available for SIGNOR curated interactions for SETMAR Gene

Drugs & Compounds for SETMAR Gene

(2) Drugs for SETMAR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with SETMAR: view

Transcripts for SETMAR Gene

Unigene Clusters for SETMAR Gene

SET domain and mariner transposase fusion gene:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SETMAR Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d
SP1: - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - - - - - -
SP8:

Relevant External Links for SETMAR Gene

GeneLoc Exon Structure for
SETMAR
ECgene alternative splicing isoforms for
SETMAR

Expression for SETMAR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SETMAR Gene

Protein differential expression in normal tissues from HIPED for SETMAR Gene

This gene is overexpressed in Heart (9.2), Pancreas (9.1), Fetal Brain (8.9), and Bone marrow mesenchymal stem cell (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SETMAR Gene



Protein tissue co-expression partners for SETMAR Gene

NURSA nuclear receptor signaling pathways regulating expression of SETMAR Gene:

SETMAR

SOURCE GeneReport for Unigene cluster for SETMAR Gene:

Hs.475300

mRNA Expression by UniProt/SwissProt for SETMAR Gene:

Q53H47-SETMR_HUMAN
Tissue specificity: Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle.
genes like me logo Genes that share expression patterns with SETMAR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SETMAR Gene

Orthologs for SETMAR Gene

This gene was present in the common ancestor of animals.

Orthologs for SETMAR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SETMAR 34
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia LOC534913 34
  • 90.76 (n)
SETMAR 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SETMAR 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Setmar 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SETMAR 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SETMAR 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101747682 34
  • 64.66 (n)
lizard
(Anolis carolinensis)
Reptilia SETMAR 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia setmar 34
  • 59.26 (n)
zebrafish
(Danio rerio)
Actinopterygii setmar 35
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4565 34
  • 54.36 (n)
G9a 35
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06B8.5 36
  • 43 (a)
C16C8.6 36
  • 43 (a)
C54H2.2 36
  • 43 (a)
F30B5.5 36
  • 43 (a)
K09E10.3 36
  • 43 (a)
T27E7.7 36
  • 43 (a)
Y49F6A.4 36
  • 43 (a)
Y73B3A.19 36
  • 43 (a)
Y73F8A.29 36
  • 43 (a)
ZC53.3 36
  • 43 (a)
ZK563.3 36
  • 43 (a)
B0564.5 36
  • 42 (a)
C14A6.4 36
  • 42 (a)
C29E6.6 36
  • 42 (a)
C30G4.1 36
  • 42 (a)
C31A11.2 36
  • 42 (a)
C33A12.5 36
  • 42 (a)
C36A4.7 36
  • 42 (a)
E03H4.1 36
  • 42 (a)
F11D11.9 36
  • 42 (a)
F15E11.6 36
  • 42 (a)
F16D3.5 36
  • 42 (a)
F27B3.4 36
  • 42 (a)
F35B3.2 36
  • 42 (a)
F35B3.6 36
  • 42 (a)
F47G9.5 36
  • 42 (a)
F56A4.8 36
  • 42 (a)
F56D5.7 36
  • 42 (a)
K07C6.12 36
  • 42 (a)
M01D1.4 36
  • 42 (a)
R05G6.2 36
  • 42 (a)
R07H5.5 36
  • 42 (a)
R08F11.6 36
  • 42 (a)
R10E4.8 36
  • 42 (a)
T06D8.4 36
  • 42 (a)
T12B5.6 36
  • 42 (a)
T26H8.1 36
  • 42 (a)
Y105C5B.22 36
  • 42 (a)
Y116A8B.2 36
  • 42 (a)
Y119D3A.5 36
  • 42 (a)
Y37A1A.1 36
  • 42 (a)
Y39A3A.1 36
  • 42 (a)
Y45F10C.5 36
  • 42 (a)
Y45G12C.13 36
  • 42 (a)
Y51H4A.8 36
  • 42 (a)
Y53F4B.34 36
  • 42 (a)
Y64G10A.5 36
  • 42 (a)
Y71D11A.4 36
  • 42 (a)
Y7A5A.4 36
  • 42 (a)
Y95B8A.3 36
  • 42 (a)
ZC132.1 36
  • 42 (a)
F44F4.8 36
  • 42 (a)
ZK546.8 36
  • 42 (a)
ZK1225.3 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToOne
Species where no ortholog for SETMAR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SETMAR Gene

ENSEMBL:
Gene Tree for SETMAR (if available)
TreeFam:
Gene Tree for SETMAR (if available)

Paralogs for SETMAR Gene

(3) SIMAP similar genes for SETMAR Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SETMAR Gene

genes like me logo Genes that share paralogs with SETMAR: view

Variants for SETMAR Gene

Sequence variations from dbSNP and Humsavar for SETMAR Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10049315 -- 4,302,575(+) GGGCA(A/T)AATGA intron-variant, upstream-variant-2KB
rs10510291 -- 4,306,872(+) ACAAG(C/G)ATATC intron-variant
rs10585687 -- 4,316,040(+) CGAGA(-/CT)CTGTC intron-variant
rs111284036 -- 4,312,734(+) TATTG(A/G)AGAGA intron-variant
rs111290130 -- 4,306,072(+) TACAA(C/G)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SETMAR Gene

Variant ID Type Subtype PubMed ID
dgv272n21 CNV loss 19592680
dgv8185n54 CNV loss 21841781
esv2759126 CNV loss 17122850
esv3575535 CNV gain 25503493
esv3893632 CNV loss 25118596
esv3893640 CNV loss 25118596
nsv1003234 CNV gain 25217958
nsv1006124 CNV loss 25217958
nsv469899 CNV loss 18288195
nsv589451 CNV loss 21841781
nsv997886 CNV gain 25217958

Variation tolerance for SETMAR Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.29; 76.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SETMAR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SETMAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SETMAR Gene

Disorders for SETMAR Gene

MalaCards: The human disease database

(1) MalaCards diseases for SETMAR Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mantle cell lymphoma
  • lymphoma, mantle cell
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SETMAR

Genetic Association Database (GAD)
SETMAR
Human Genome Epidemiology (HuGE) Navigator
SETMAR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SETMAR
genes like me logo Genes that share disorders with SETMAR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SETMAR Gene

Publications for SETMAR Gene

  1. Molecular evolution of an ancient mariner transposon, Hsmar1, in the human genome. (PMID: 9461395) Robertson H.M. … Zumpano K.L. (Gene 1997) 2 3 4 64
  2. The DDN catalytic motif is required for Metnase functions in non- homologous end joining (NHEJ) repair and replication restart. (PMID: 24573677) Kim H.S. … Lee S.H. (J. Biol. Chem. 2014) 3 4 64
  3. Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart. (PMID: 22231448) Hromas R. … Lee S.H. (Oncogene 2012) 3 4 64
  4. Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining. (PMID: 21187428) Fnu S. … Hromas R. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 64
  5. Metnase promotes restart and repair of stalled and collapsed replication forks. (PMID: 20457750) De Haro L.P. … Nickoloff J.A. (Nucleic Acids Res. 2010) 3 4 64

Products for SETMAR Gene

Sources for SETMAR Gene

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