SETD9 Gene
protein-coding GIFtS: 37
GCID: GC05P056206
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SET domain containing 9(Previous name: chromosome 5 open reading frame 35 )
(Previous symbol: C5orf35)
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Aliases
for SETD9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SET Domain Containing 91 2 | | C5orf351 2 3 | | MGC336481 | | Chromosome 5 Open Reading Frame 351 | | SET Domain-Containing Protein 92 |
Export aliases for SETD9 gene to outside databases |
Summaries
for SETD9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SETD9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SETD9
Other transcription factors
Search SABiosciences Chromatin IP Primers for SETD9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SETD9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2SETD9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P056206: view genomic region
(about GC identifiers)
Start:
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56,205,087 bp from pter |
End:
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56,221,359 bp from pter |
Size:
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16,273 bases |
Orientation:
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plus strand |
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Proteins
for SETD9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SETD9_HUMAN, Q8NE22 (See
protein sequence)Recommended Name: SET domain-containing protein 9 Size: 299 amino acids; 34095 Da
Secondary accessions: F5H713Alternative splicing: 2 isoforms: Q8NE22-1 Q8NE22-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SETD9: NX_Q8NE22
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NE22
SETD9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001165461.1 NP_714917.2
ENSEMBL proteins: ENSP00000285947 ENSP00000398449 ENSP00000406183 ENSP00000442886
Human Recombinant Protein Products:
SETD9 Antibody Products:
Assay Products for SETD9: |
Protein
Domains /
Families
for SETD9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SETD9 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NE22ProtoNet protein and cluster: Q8NE22 UniProtKB/Swiss-Prot: SETD9_HUMAN, Q8NE22Similarity: Contains 1 SET domain |
Function
for SETD9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SETD9 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SETD9 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for SETD9 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SETD9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD9 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD9 |
|
Pathways & Interactions
for SETD9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SETD9
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for SETD9 (ENSP000002859474) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
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Drugs & Compounds
for SETD9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SETD9
Search CenterWatch for drugs/clinical trials and news about SETD9
|
Transcripts
for SETD9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SETD9 gene (2 alternative transcripts): NM_001171990.1 NM_153706.3 Unigene Cluster for SETD9: SET domain containing 9 Hs.85950 [show with all ESTs]Unigene Representative Sequence: AK09314711 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000475908 ENST00000285947(uc003jqx.3) ENST00000498322 ENST00000418299
ENST00000480414 ENST00000463805 ENST00000472636 ENST00000423328 ENST00000477359
ENST00000497763 ENST00000541720(uc021xyu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SETD9 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SETD9 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SETD9 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SETD9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD9 |
Additional cDNA sequence: AK093147.1 AK309152.1 BC036528.1 5 DOTS entries: DT.105460 DT.70103748 DT.99942003 DT.206555 DT.97861281 24/45 AceView cDNA sequences (see all 45): CR625068 AK093147 AA758553 AI989350 AA621479 BP342016 BG574944 BC036528 BX094293 BG721885 BP336535 BQ429063 AF114126 BX394558 AW169924 AI082667 AI208292 BG719045 BG703195 BI093176 AI239728 AA194646 AA404649 AA314907
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SETD9 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
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| SP1: | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SETD9
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Expression
for SETD9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SETD9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAAAAGCTA
About this image
See SETD9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SETD9
SOURCE GeneReport for Unigene cluster: Hs.85950
SABiosciences Custom PCR Arrays for SETD9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SETD9
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SETD9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SETD9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SETD9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD9 |
Orthologs
for SETD9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SETD9 gene from 3/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SETD91 |
SET domain containing 9 |
67.12(n)
66.33(a) |
|
770222 XM_001233555.2 XP_001233556.2 |
lizard
(Anolis carolinensis) |
Reptilia |
C5orf356 |
-- |
68(a) |
1 ↔ 1 |
2(1876665-1885644) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.166432 |
Transcribed sequences |
73.03(n) |
|
BI979940.1 |
Species with no ortholog for SETD9
ENSEMBL Gene Tree for SETD9 (if available)
TreeFam Gene Tree for SETD9 (if available) |
Paralogs
for SETD9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SETD9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SETD9 (56205087 - 56221359 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SETD9: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SETD9 |
|
Disorders
/ Diseases
for SETD9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SETD9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SETD9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SETD9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Uncovering the human methyltransferasome. (PubMed id 20930037)1, 3 Petrossian T.C. and Clarke S.G. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SETD9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SETD9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SETD9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SETD9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SETD9 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SETD9 gene:
Search GeneIP for patents involving SETD9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SETD9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SETD9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SETD9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SETD9 | | | OriGene Protein Over-expression Lysate for SETD9 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SETD9 | | OriGene 3'-UTR Clone for SETD9 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SETD9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SETD9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SETD9 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SETD9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SETD9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SETD9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SETD9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SETD9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SETD9 |
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 |  |  |  | |
| | | | Search Tocris compounds for SETD9 |
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 | | | SETD9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD9 |
|  |  |  | | | | Search ThermoFisher Antibodies for SETD9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD9 |
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