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Aliases for SETD9 Gene

Aliases for SETD9 Gene

  • SET Domain Containing 9 2 3 5
  • C5orf35 3 4
  • Chromosome 5 Open Reading Frame 35 2
  • EC 2.1.1.- 4

External Ids for SETD9 Gene

Previous HGNC Symbols for SETD9 Gene

  • C5orf35

Previous GeneCards Identifiers for SETD9 Gene

  • GC05P056206

Summaries for SETD9 Gene

GeneCards Summary for SETD9 Gene

SETD9 (SET Domain Containing 9) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of TP53 Activity. GO annotations related to this gene include methyltransferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SETD9 Gene

Genomics for SETD9 Gene

Regulatory Elements for SETD9 Gene

Enhancers for SETD9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SETD9 on UCSC Golden Path with GeneCards custom track

Promoters for SETD9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SETD9 on UCSC Golden Path with GeneCards custom track

Genomic Location for SETD9 Gene

56,909,259 bp from pter
56,925,532 bp from pter
16,274 bases
Plus strand

Genomic View for SETD9 Gene

Genes around SETD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SETD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SETD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SETD9 Gene

Proteins for SETD9 Gene

  • Protein details for SETD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SET domain-containing protein 9
    Protein Accession:
    Secondary Accessions:
    • F5H713

    Protein attributes for SETD9 Gene

    299 amino acids
    Molecular mass:
    34095 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SETD9 Gene


neXtProt entry for SETD9 Gene

Proteomics data for SETD9 Gene at MOPED

Post-translational modifications for SETD9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SETD9 Gene

Domains & Families for SETD9 Gene

Protein Domains for SETD9 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
genes like me logo Genes that share domains with SETD9: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SETD9 Gene

Function for SETD9 Gene

Enzyme Numbers (IUBMB) for SETD9 Gene

genes like me logo Genes that share phenotypes with SETD9: view

Animal Model Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SETD9 Gene

Localization for SETD9 Gene

Subcellular locations from

Jensen Localization Image for SETD9 Gene COMPARTMENTS Subcellular localization image for SETD9 gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SETD9 Gene

Pathways & Interactions for SETD9 Gene

genes like me logo Genes that share pathways with SETD9: view

Interacting Proteins for SETD9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000285947 for SETD9 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SETD9 Gene


No data available for SIGNOR curated interactions for SETD9 Gene

Drugs & Compounds for SETD9 Gene

No Compound Related Data Available

Transcripts for SETD9 Gene

Unigene Clusters for SETD9 Gene

SET domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SETD9 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - -

Relevant External Links for SETD9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SETD9 Gene

mRNA expression in normal human tissues for SETD9 Gene

mRNA differential expression in normal tissues according to GTEx for SETD9 Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for SETD9 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SETD9 Gene

SOURCE GeneReport for Unigene cluster for SETD9 Gene Hs.85950

genes like me logo Genes that share expression patterns with SETD9: view

Protein tissue co-expression partners for SETD9 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SETD9 Gene

Orthologs for SETD9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SETD9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SETD9 35
  • 92.87 (n)
  • 91.97 (a)
SETD9 36
  • 92 (a)
(Canis familiaris)
Mammalia SETD9 35
  • 93.31 (n)
  • 92.64 (a)
SETD9 36
  • 93 (a)
(Pan troglodytes)
Mammalia SETD9 35
  • 99.89 (n)
  • 99.67 (a)
SETD9 36
  • 100 (a)
(Monodelphis domestica)
Mammalia SETD9 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia SETD9 36
  • 72 (a)
(Gallus gallus)
Aves CZH5ORF35 35
  • 67.12 (n)
  • 66.33 (a)
SETD9 36
  • 66 (a)
(Anolis carolinensis)
Reptilia SETD9 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia setd9 35
  • 65.86 (n)
  • 64.83 (a)
(Danio rerio)
Actinopterygii Dr.16643 35
LOC793111 35
  • 59.64 (n)
  • 60.36 (a)
SETD9 36
  • 60 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7120 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for SETD9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SETD9 Gene

Gene Tree for SETD9 (if available)
Gene Tree for SETD9 (if available)

Paralogs for SETD9 Gene

No data available for Paralogs for SETD9 Gene

Variants for SETD9 Gene

Sequence variations from dbSNP and Humsavar for SETD9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_034875 -
rs40497 - 56,913,908(-) CATTT(C/T)TAAAG reference, missense
rs832534 -- 56,917,845(-) GGAGT(C/T)AGGTC intron-variant
rs832535 -- 56,917,507(-) GACAC(A/G)GGGAA intron-variant, downstream-variant-500B
rs832536 -- 56,916,768(-) TATAA(A/G)CTCAT intron-variant

Variation tolerance for SETD9 Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.04; 96.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SETD9 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SETD9 Gene

Disorders for SETD9 Gene

Relevant External Links for SETD9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SETD9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SETD9 Gene

Publications for SETD9 Gene

  1. Uncovering the human methyltransferasome. (PMID: 20930037) Petrossian T.C. … Clarke S.G. (Mol. Cell Proteomics 2011) 2 3 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SETD9 Gene

Sources for SETD9 Gene