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Aliases for SETD9 Gene

Aliases for SETD9 Gene

  • SET Domain Containing 9 2 3
  • C5orf35 3 4
  • Chromosome 5 Open Reading Frame 35 2
  • SET Domain-Containing Protein 9 3
  • EC 2.1.1.- 4

External Ids for SETD9 Gene

Previous Symbols for SETD9 Gene

  • C5orf35

Summaries for SETD9 Gene

GeneCards Summary for SETD9 Gene

SETD9 (SET Domain Containing 9) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SETD9 Gene

Genomics for SETD9 Gene

Genomic Location for SETD9 Gene

56,909,260 bp from pter
56,925,532 bp from pter
16,273 bases
Plus strand

Genomic View for SETD9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SETD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SETD9 Gene

No data available for Regulatory Elements for SETD9 Gene

Proteins for SETD9 Gene

  • Protein details for SETD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SET domain-containing protein 9
    Protein Accession:
    Secondary Accessions:
    • F5H713

    Protein attributes for SETD9 Gene

    299 amino acids
    Molecular mass:
    34095 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SETD9 Gene


neXtProt entry for SETD9 Gene

Proteomics data for SETD9 Gene at MOPED

Post-translational modifications for SETD9 Gene

No Post-translational modifications

Other Protein References for SETD9 Gene

No data available for DME Specific Peptides for SETD9 Gene

Domains for SETD9 Gene

Protein Domains for SETD9 Gene



  • Contains 1 SET domain.:
    • Q8NE22
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.:
    • Q8NE22
genes like me logo Genes that share domains with SETD9: view

No data available for Gene Families for SETD9 Gene

Function for SETD9 Gene

Enzyme Numbers (IUBMB) for SETD9 Gene

Gene Ontology (GO) - Molecular Function for SETD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with SETD9: view

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SETD9 Gene

Localization for SETD9 Gene

No data available for Gene Ontology (GO) - Cellular Components for SETD9 Gene

Pathways for SETD9 Gene

SuperPathways for SETD9 Gene

No Data Available

Interacting Proteins for SETD9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000285947 for SETD9 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SETD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with SETD9: view

No data available for Pathways by source for SETD9 Gene

Transcripts for SETD9 Gene

Unigene Clusters for SETD9 Gene

SET domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SETD9 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - -

Relevant External Links for SETD9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SETD9 Gene

mRNA expression in normal human tissues for SETD9 Gene

mRNA differential expression in normal tissues according to GTEx for SETD9 Gene

This gene is overexpressed in Testis (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SETD9 Gene

SOURCE GeneReport for Unigene cluster for SETD9 Gene Hs.85950

genes like me logo Genes that share expressions with SETD9: view

Orthologs for SETD9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SETD9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SETD9 36
  • 99.89 (n)
  • 99.67 (a)
SETD9 37
  • 100 (a)
(Bos Taurus)
Mammalia SETD9 36
  • 92.87 (n)
  • 91.97 (a)
SETD9 37
  • 92 (a)
(Canis familiaris)
Mammalia SETD9 36
  • 93.31 (n)
  • 92.64 (a)
SETD9 37
  • 93 (a)
(Monodelphis domestica)
Mammalia SETD9 37
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia SETD9 37
  • 72 (a)
(Gallus gallus)
Aves CZH5ORF35 36
  • 67.12 (n)
  • 66.33 (a)
SETD9 37
  • 66 (a)
(Anolis carolinensis)
Reptilia SETD9 37
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia setd9 36
  • 65.86 (n)
  • 64.83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7120 36
(Danio rerio)
Actinopterygii Dr.16643 36
LOC793111 36
  • 59.64 (n)
  • 60.36 (a)
SETD9 37
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
Species with no ortholog for SETD9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SETD9 Gene

Gene Tree for SETD9 (if available)
Gene Tree for SETD9 (if available)

Paralogs for SETD9 Gene

No data available for Paralogs for SETD9 Gene

Variants for SETD9 Gene

Sequence variations from dbSNP and Humsavar for SETD9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs33317 -- 56,913,448(+) GTGCG(A/G)TCTCT intron-variant
rs33318 -- 56,912,587(-) ACTGG(A/C)AAAAG intron-variant
rs33319 -- 56,910,848(-) AGTGG(G/T)AGAGC intron-variant, upstream-variant-2KB
rs33320 -- 56,910,702(-) ACATC(A/G)TATAC intron-variant, upstream-variant-2KB
rs33321 -- 56,910,246(-) CCTGG(A/C)TTGGC intron-variant, utr-variant-5-prime, upstream-variant-2KB

Relevant External Links for SETD9 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Structural Variations from Database of Genomic Variants (DGV) for SETD9 Gene

Disorders for SETD9 Gene

No disorders were found for SETD9 Gene.

No data available for UniProtKB/Swiss-Prot for SETD9 Gene

Publications for SETD9 Gene

  1. Uncovering the human methyltransferasome. (PMID: 20930037) Petrossian T.C. … Clarke S.G. (Mol. Cell Proteomics 2011) 2 3
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for SETD9 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SETD9
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SETD9
    • Block miRNA regulation of SETD9 using miScript Target Protectors

    Sources for SETD9 Gene

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