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Aliases for SETD9 Gene

Aliases for SETD9 Gene

  • SET Domain Containing 9 2 3 5
  • C5orf35 3 4
  • Chromosome 5 Open Reading Frame 35 2
  • SET Domain-Containing Protein 9 3
  • EC 2.1.1.- 4

External Ids for SETD9 Gene

Previous HGNC Symbols for SETD9 Gene

  • C5orf35

Previous GeneCards Identifiers for SETD9 Gene

  • GC05P056206

Summaries for SETD9 Gene

GeneCards Summary for SETD9 Gene

SETD9 (SET Domain Containing 9) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of TP53 Activity. GO annotations related to this gene include methyltransferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SETD9 Gene

Genomics for SETD9 Gene

Regulatory Elements for SETD9 Gene

Enhancers for SETD9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F056908 1.1 ENCODE 70.4 +0.4 399 3.3 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SETD9 ENSG00000271828 LOC105378980
GH05F056826 1.7 FANTOM5 Ensembl ENCODE 44.3 -75.4 -75359 15.0 PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SETD9 GPBP1 HNRNPH1P3 ENSG00000237705 LINC01948 RNU6ATAC2P C5orf67 MAP3K1 GC05P056845 GC05P056846
GH05F056950 0.9 ENCODE 74 +42.3 42267 2.7 TBP ZNF76 FEZF1 ZBTB40 YY1 GLIS2 EGR1 ZNF366 SCRT2 EGR2 SETD9 LOC105378980 ENSG00000235635 MIER3
GH05F056847 1.1 Ensembl ENCODE 54.4 -57.6 -57559 9.0 PKNOX1 BMI1 THRB YY1 GATA2 ZNF366 ZNF263 HCFC1 CEBPB TBX21 SETD9 MAP3K1 LOC105378980 LINC01948 ENSG00000235635 MIER3 C5orf67 GC05P056845 GC05P056846 ENSG00000237705
GH05F056814 1.1 ENCODE 44.3 -92.5 -92500 6.3 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 SETD9 ENSG00000271828 C5orf67 MAP3K1 GC05P056845 GC05P056846
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SETD9 on UCSC Golden Path with GeneCards custom track

Promoters for SETD9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001280642 242 3000 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for SETD9 Gene

Chromosome:
5
Start:
56,909,259 bp from pter
End:
56,925,532 bp from pter
Size:
16,274 bases
Orientation:
Plus strand

Genomic View for SETD9 Gene

Genes around SETD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SETD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SETD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SETD9 Gene

Proteins for SETD9 Gene

  • Protein details for SETD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE22-SETD9_HUMAN
    Recommended name:
    SET domain-containing protein 9
    Protein Accession:
    Q8NE22
    Secondary Accessions:
    • F5H713

    Protein attributes for SETD9 Gene

    Size:
    299 amino acids
    Molecular mass:
    34095 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SETD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SETD9 Gene

Post-translational modifications for SETD9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SETD9 Gene

Domains & Families for SETD9 Gene

Protein Domains for SETD9 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NE22

UniProtKB/Swiss-Prot:

SETD9_HUMAN :
  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
Domain:
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
genes like me logo Genes that share domains with SETD9: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SETD9 Gene

Function for SETD9 Gene

Enzyme Numbers (IUBMB) for SETD9 Gene

Gene Ontology (GO) - Molecular Function for SETD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016278 lysine N-methyltransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SETD9: view
genes like me logo Genes that share phenotypes with SETD9: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SETD9 Gene

Localization for SETD9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SETD9 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 1

Gene Ontology (GO) - Cellular Components for SETD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with SETD9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SETD9 Gene

Pathways & Interactions for SETD9 Gene

genes like me logo Genes that share pathways with SETD9: view

Pathways by source for SETD9 Gene

Interacting Proteins for SETD9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000285947%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q8NE22-SETD9_HUMAN ENSP00000285947 for SETD9 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SETD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
GO:1901796 regulation of signal transduction by p53 class mediator TAS --
genes like me logo Genes that share ontologies with SETD9: view

No data available for SIGNOR curated interactions for SETD9 Gene

Transcripts for SETD9 Gene

Unigene Clusters for SETD9 Gene

SET domain containing 9:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SETD9 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP7:

Relevant External Links for SETD9 Gene

GeneLoc Exon Structure for
SETD9
ECgene alternative splicing isoforms for
SETD9

Expression for SETD9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SETD9 Gene

mRNA differential expression in normal tissues according to GTEx for SETD9 Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for SETD9 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SETD9 Gene



Protein tissue co-expression partners for SETD9 Gene

NURSA nuclear receptor signaling pathways regulating expression of SETD9 Gene:

SETD9

SOURCE GeneReport for Unigene cluster for SETD9 Gene:

Hs.85950
genes like me logo Genes that share expression patterns with SETD9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SETD9 Gene

Orthologs for SETD9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SETD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SETD9 34 35
  • 99.89 (n)
dog
(Canis familiaris)
Mammalia SETD9 34 35
  • 93.31 (n)
cow
(Bos Taurus)
Mammalia SETD9 34 35
  • 92.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SETD9 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SETD9 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH5ORF35 34
  • 67.12 (n)
SETD9 35
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SETD9 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia setd9 34
  • 65.86 (n)
zebrafish
(Danio rerio)
Actinopterygii SETD9 35
  • 60 (a)
OneToOne
LOC793111 34
  • 59.64 (n)
Dr.16643 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7120 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToOne
Species where no ortholog for SETD9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SETD9 Gene

ENSEMBL:
Gene Tree for SETD9 (if available)
TreeFam:
Gene Tree for SETD9 (if available)

Paralogs for SETD9 Gene

No data available for Paralogs for SETD9 Gene

Variants for SETD9 Gene

Sequence variations from dbSNP and Humsavar for SETD9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10042998 -- 56,909,472(+) TCAGG(A/G)AAGGG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs10045390 -- 56,921,514(+) TACTG(C/T)GTAAA intron-variant, utr-variant-3-prime
rs10054376 -- 56,921,418(+) GCTAT(A/C)CTTCA intron-variant, utr-variant-3-prime
rs10058209 -- 56,916,516(+) TATAA(C/T)GTCAT intron-variant
rs10061565 -- 56,928,351(+) ccatc(C/T)ttacc intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SETD9 Gene

Variant ID Type Subtype PubMed ID
nsv598210 CNV loss 21841781

Variation tolerance for SETD9 Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.04; 96.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SETD9 Gene

Human Gene Mutation Database (HGMD)
SETD9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SETD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SETD9 Gene

Disorders for SETD9 Gene

Relevant External Links for SETD9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SETD9

No disorders were found for SETD9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SETD9 Gene

Publications for SETD9 Gene

  1. Uncovering the human methyltransferasome. (PMID: 20930037) Petrossian T.C. … Clarke S.G. (Mol. Cell Proteomics 2011) 2 3 64
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 64

Products for SETD9 Gene

Sources for SETD9 Gene

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