Aliases for SETD8 Gene
External Ids for SETD8 Gene
Previous GeneCards Identifiers for SETD8 Gene
GeneCards Summary for SETD8 Gene
SETD8 (SET Domain Containing (Lysine Methyltransferase) 8) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Mitotic Prophase. GO annotations related to this gene include transcription corepressor activity and histone-lysine N-methyltransferase activity.
UniProtKB/Swiss-Prot for SETD8 Gene
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates Lys-20 of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at Lys-382, leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.