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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SETD7 Gene

protein-coding   GIFtS: 64
GCID: GC04M140417

SET Domain Containing (Lysine Methyltransferase) 7

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SET Domain Containing (Lysine Methyltransferase) 71 2     H3-K4-HMTase SETD72 3
SET72 3 5     SET Domain-Containing Protein 72 3
Histone H3-K4 Methyltransferase SETD72 3     KIAA17173 5
Lysine N-Methyltransferase 72 3     Histone H3-Lysine 4-Specific Methyltransferase2
KMT72 3     Histone-Lysine N-Methyltransferase SETD72
SET7/92 3     EC 2.1.1.433
SET92 3     

External Ids:    HGNC: 304121   Entrez Gene: 808542   Ensembl: ENSG000001453917   OMIM: 6065945   UniProtKB: Q8WTS63   

Export aliases for SETD7 gene to outside databases

Previous GC identifers: GC04M140646 GC04M136156


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SETD7 Gene: 
SETD7 (SET domain containing (lysine methyltransferase) 7) is a protein-coding gene. Diseases associated with SETD7 include hyperglycemia, and vasculitis, and among its related super-pathways are Signal transduction Activin A signaling regulation. GO annotations related to this gene include protein-lysine N-methyltransferase activity and p53 binding.

UniProtKB/Swiss-Prot: SETD7_HUMAN, Q8WTS6
Function: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation
represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional
activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to
activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10,
and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of
TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53,
stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation

Gene Wiki entry for SETD7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SETD7 gene promoter:
         c-Fos   AP-1   ATF-2   SEF-1 (1)   Nkx2-5   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSETD7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SETD7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SETD7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28   Ensembl cytogenetic band:  4q31.1   HGNC cytogenetic band: 4q31.1

SETD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETD7 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M140417:  view genomic region     (about GC identifiers)

Start:
140,417,095 bp from pter      End:
140,477,928 bp from pter
Size:
60,834 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SETD7_HUMAN, Q8WTS6 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SETD7  
Size: 366 amino acids; 40721 Da
Subunit: Interacts with IPF1/PDX-1
Subcellular location: Nucleus. Chromosome (Probable)
Miscellaneous: Monomethyltransferase activity is achieved by disrupting the formation at near-attack conformations
for the dimethylation reaction
Sequence caution: Sequence=BAB21808.1; Type=Erroneous initiation;
6/25 PDB 3D structures from and Proteopedia for SETD7 (see all 25):
1H3I (3D)        1MT6 (3D)        1MUF (3D)        1N6A (3D)        1N6C (3D)        1O9S (3D)    
Secondary accessions: B5WWL3 Q0VAH3 Q4W5A9 Q9C0E6

Explore the universe of human proteins at neXtProt for SETD7: NX_Q8WTS6

Explore proteomics data for SETD7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WTS6

  • SETD7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SETD7 Protein Expression
    REFSEQ proteins: NP_085151.1  
    ENSEMBL proteins: 
     ENSP00000427300   ENSP00000274031   ENSP00000385913   ENSP00000384336  

    Human Recombinant Protein Products for SETD7: 
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    Sino Biological Recombinant Protein for SETD7
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SETD7
    Cloud-Clone Corp. Proteins for SETD7 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005694chromosome IEA--

    SETD7 for ontologies           About GeneDecksing



    SETD7 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SETD7 

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SETD7 
    Cloud-Clone Corp. CLIAs for SETD7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KMT: Chromatin-modifying enzymes / K-methyltransferases

    3 InterPro protein domains:
     IPR001214 SET_dom
     IPR017155 Hist-Lys_N-MeTrfase_SET
     IPR003409 MORN

    Graphical View of Domain Structure for InterPro Entry Q8WTS6

    ProtoNet protein and cluster: Q8WTS6

    1 Blocks protein domain: IPB001214 Nuclear protein SET

    UniProtKB/Swiss-Prot: SETD7_HUMAN, Q8WTS6
    Domain: The SET domain is necessary but not sufficient for histone methyltransferase activity
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. SET7 subfamily
    Similarity: Contains 3 MORN repeats
    Similarity: Contains 1 SET domain


    SETD7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SETD7_HUMAN, Q8WTS6
    Function: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation
    represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional
    activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to
    activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10,
    and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of
    TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53,
    stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]
    Biophysicochemical properties: Kinetic parameters: KM=29 uM for histone H3; KM=12 uM for TAF10; KM=69 uM for
    p53/TP53;

         Enzyme Number (IUBMB): EC 2.1.1.431

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI17108971
    GO:0005515protein binding IPI12540855
    GO:0016279protein-lysine N-methyltransferase activity IDA16415881
    GO:0018024histone-lysine N-methyltransferase activity NAS12514135
         
    SETD7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SETD7:
     G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Setd7):
     cellular  homeostasis/metabolism  immune system  mortality/aging 

    SETD7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SETD7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SETD7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SETD7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SETD7 

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SETD7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Histone modification0.31
    2p53 pathway
    p53 pathway
    3Selected targets of ESR1
    Selected targets of ESR1
    4Lysine degradation
    Lysine degradation
    5Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for SETD7
        Selected targets of ESR1
    Histone modification


    1 Cell Signaling Technology (CST) Pathway for SETD7
        Chromatin Regulation / Acetylation

    1 BioSystems Pathway for SETD7
        p53 pathway



    1         Kegg Pathway  (Kegg details for SETD7):
        Lysine degradation


    SETD7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SETD7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for SETD7 (Q8WTS61, 2, 3 ENSP000002740314) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3BP684311, 3EBI-1268586,EBI-79722 I2D: score=2 
    HIST1H3CP684311, 3EBI-1268586,EBI-79722 I2D: score=2 
    HIST1H3DP684311, 3EBI-1268586,EBI-79722 I2D: score=2 
    HIST1H3EP684311, 3EBI-1268586,EBI-79722 I2D: score=2 
    HIST1H3FP684311, 3EBI-1268586,EBI-79722 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0016568chromatin modification NAS12514135
    GO:0018026peptidyl-lysine monomethylation IDA17108971
    GO:0018027peptidyl-lysine dimethylation IDA17108971

    SETD7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SETD7 for compounds           About GeneDecksing

    EMD Millipore small molecules for SETD7:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SETD7

    3 HMDB Compounds for SETD7    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Lysine(+)-S-Lysine (see all 25)56-87-1--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    1 DrugBank Compound for SETD7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S-Adenosyl-L-Homocysteine-- 979-92-0target----

    1 Novoseek inferred chemical compound relationship for SETD7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 58.8 1 19208907 (1), 17646389 (1), 18581285 (1)

    Search CenterWatch for drugs/clinical trials and news about SETD7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SETD7 gene: 
    NM_030648.2  

    Unigene Cluster for SETD7:

    SET domain containing (lysine methyltransferase) 7
    Hs.480792  [show with all ESTs]
    Unigene Representative Sequence: NM_030648
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506866 ENST00000515101 ENST00000274031(uc003ihw.3) ENST00000404104(uc003ihx.3)
    ENST00000406354
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/156 QIAGEN miScript miRNA Assays for microRNAs that regulate SETD7 (see all 156):
    hsa-miR-579 hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-342-3p hsa-miR-502-3p hsa-miR-149 hsa-miR-3170
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    Additional mRNA sequence: 

    AB051504.1 AF448510.1 AF462150.1 AK024846.1 AK310856.1 BC012784.2 BC040990.2 BC066361.1 
    BC110904.1 BC121055.1 BC121056.1 

    8 DOTS entries:

    DT.454652  DT.99986131  DT.65288295  DT.95362232  DT.95303625  DT.99938792  DT.121230141  DT.40247526 

    24/200 AceView cDNA sequences (see all 200):

    AI129266 AB051504 BG151531 AI658914 BQ685489 AW027264 AI802989 CD674192 
    AW779055 AA888010 BQ015519 Z38699 AA736788 BU685052 BM772289 AK024846 
    AA465638 AA888104 BM976627 BP363913 AA411643 AI094722 CK906166 NM_030648 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SETD7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:              -                 -     -                                 
    SP2:                                                                        
    SP3:              -                                                         


    ECgene alternative splicing isoforms for SETD7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SETD7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCAAGAGA
    SETD7 Expression
    About this image


    See SETD7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SETD7

    SOURCE GeneReport for Unigene cluster: Hs.480792

    UniProtKB/Swiss-Prot: SETD7_HUMAN, Q8WTS6
    Tissue specificity: Widely expressed. Expressed in pancreatic islets

        SABiosciences Expression via Pathway-Focused PCR Array including SETD7: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SETD7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SETD7 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Setd71 , 5 SET domain containing (lysine methyltransferase) 71, 5 87.98(n)1
    95.36(a)1
      3 (22.50 cM)5
    732511  NM_080793.51  NP_542983.31 
     515153195 
    chicken
    (Gallus gallus)
    Aves SETD71 SET domain containing (lysine methyltransferase) 7 80.97(n)
    88.25(a)
      422443  XM_420409.3  XP_420409.2 
    lizard
    (Anolis carolinensis)
    Reptilia SETD76
    Uncharacterized protein
    84(a)
    1 ↔ 1
    5(120205988-120227441)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.156872 Transcribed sequence with moderate similarity to protein more 77.52(n)    BX732798.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.128762 Transcribed sequence with moderate similarity to protein more 74.98(n)    BM534461.1 


    ENSEMBL Gene Tree for SETD7 (if available)
    TreeFam Gene Tree for SETD7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SETD7 gene
    4 SIMAP similar genes for SETD7 using alignment to 4 protein entries:     SETD7_HUMAN (see all proteins):
    MORN4    MORN2    LOC118812    MORN1

    SETD7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1054 SNPs in SETD7 are shown (see all 1054)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2003087751,2
    --140426748(+) AGATT-/AAAAAA 1 -- ds50010--------
    rs1141045741,2
    --140426772(+) TGACTA/GTGATT 1 -- ds50010--------
    rs1911279311,2
    --140426845(+) TACCAC/TAACGT 1 -- ds50010--------
    rs1832678691,2
    --140427093(+) AAAATA/GTAAAG 1 -- ds50010--------
    rs1509957391,2
    --140427236(+) GCGCAA/GTTATA 1 -- ut310--------
    rs116311,2
    C,F,H--140427495(+) TAACCG/ATGATG 1 -- ut31 ese38Minor allele frequency- A:0.06MN NS NA WA 1094
    rs1408771651,2
    --140427585(+) ATGTAC/TTTCAG 1 -- ut310--------
    rs1501689011,2
    --140427637(+) AGAAGA/GGAGCT 1 -- ut310--------
    rs1383552031,2
    C--140427757(+) TAGATA/GTGTTG 1 -- ut310--------
    rs1868290881,2
    --140427802(+) CACAGA/TGAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SETD7 (140417095 - 140477928 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SETD7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830085CNV Loss17160897
    esv27698CNV Loss19812545
    nsv819236CNV Gain19587683
    nsv830086CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606594    OMIM disorders: --

    9 diseases for SETD7:    About MalaCards
    hyperglycemia    vasculitis    acute leukemia    type 1 diabetes
    leukemia    hepatocellular carcinoma    pancreatitis    endotheliitis
    breast cancer


    SETD7 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SETD7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 56.8 4 18829457 (1), 19228930 (1), 20236312 (1)

    Genetic Association Database (GAD): SETD7
    Human Genome Epidemiology (HuGE) Navigator: SETD7 (1 document)

    Export disorders for SETD7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SETD7 gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with SETD7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. (PubMed id 11850410)1, 2, 3, 9 Nishioka K.... Reinberg D. (2002)
    2. Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. (PubMed id 11779497)1, 2, 3, 9 Wang H....Zhang Y. (2001)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Repression of p53 activity by Smyd2-mediated methylation. (PubMed id 17108971)1, 2 Huang J.... Berger S.L. (2006)
    5. Structural basis for the methylation site specificity of SET7/9. (PubMed id 16415881)1, 2 Couture J.-F.... Trievel R.C. (2006)
    6. Regulation of p53 activity through lysine methylation. (PubMed id 15525938)1, 2 Chuikov S....Reinberg D. (2004)
    7. Gene-specific modulation of TAF10 function by SET9-mediated methylation. (PubMed id 15099517)1, 2 Kouskouti A....Talianidis I. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Structure and catalytic mechanism of the human histone methyltransferase SET7/9. (PubMed id 12540855)1, 2 Xiao B.... Gamblin S.J. (2003)
    10. Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet. (PubMed id 12514135)1, 2 Kwon T.... Cho Y. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80854 HGNC: 30412 AceView: SET7 Ensembl:ENSG00000145391 euGenes: HUgn80854
    ECgene: SETD7 Kegg: 80854 H-InvDB: SETD7

    (According to HUGE)
    About This Section
    HUGE: KIAA1717

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SETD7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SETD7 gene:
    Search GeneIP for patents involving SETD7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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