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SETD6 Gene

protein-coding   GIFtS: 42
GCID: GC16P058549

SET Domain Containing 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SET Domain Containing 61 2
SET Domain-Containing Protein 62 3
N-Lysine Methyltransferase SETD62
EC 2.1.1.-3

External Ids:    HGNC: 261161   Entrez Gene: 799182   Ensembl: ENSG000001030377   UniProtKB: Q8TBK23   

Export aliases for SETD6 gene to outside databases

Previous GC identifers: GC16P057107 GC16P044417


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SETD6 Gene:
SETD6 (SET domain containing 6) is a protein-coding gene. GO annotations related to this gene include protein-lysine N-methyltransferase activity and NF-kappaB binding.

UniProtKB/Swiss-Prot: SETD6_HUMAN, Q8TBK2
Function: Protein-lysine N-methyltransferase that specifically monomethylates 'Lys-310' of the RELA subunit of
NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SETD6 gene promoter:
         GATA-3   AP-4   C/EBPalpha   YY1   Roaz   NF-AT4   PPAR-gamma1   NF-AT3   PPAR-gamma2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSETD6 promoter sequence
   Search Chromatin IP Primers for SETD6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SETD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q21

SETD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETD6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P058549:  view genomic region     (about GC identifiers)

Start:
58,549,383 bp from pter      End:
58,554,431 bp from pter
Size:
5,049 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SETD6_HUMAN, Q8TBK2 (See protein sequence)
Recommended Name: N-lysine methyltransferase SETD6  
Size: 473 amino acids; 53189 Da
2 PDB 3D structures from and Proteopedia for SETD6:
3QXY (3D)        3RC0 (3D)    
Secondary accessions: A8K380 B5ME38 Q9H787
Alternative splicing: 2 isoforms:  Q8TBK2-1   Q8TBK2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SETD6: NX_Q8TBK2

Explore proteomics data for SETD6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SETD6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153777.1  NP_079136.2  

    ENSEMBL proteins: 
     ENSP00000310082   ENSP00000377809   ENSP00000219315   ENSP00000398033   ENSP00000396437  
     ENSP00000412858  

    SETD6 Human Recombinant Protein Products:

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    Novus Biologicals SETD6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SETD6

     
    Search eBioscience for Proteins for SETD6 

    SETD6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cloud-Clone Corp. ELISAs for SETD6
    Cloud-Clone Corp. CLIAs for SETD6
    Search eBioscience for ELISAs for SETD6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011383 RuBisCo-cyt_methylase
     IPR001214 SET_dom
     IPR015353 Rubisco_LSMT_subst-bd

    Graphical View of Domain Structure for InterPro Entry Q8TBK2

    ProtoNet protein and cluster: Q8TBK2

    UniProtKB/Swiss-Prot: SETD6_HUMAN, Q8TBK2
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. SETD6 subfamily
    Similarity: Contains 1 SET domain


    Find genes that share domains with SETD6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SETD6_HUMAN, Q8TBK2
    Function: Protein-lysine N-methyltransferase that specifically monomethylates 'Lys-310' of the RELA subunit of
    NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0016279protein-lysine N-methyltransferase activity IDA--
    GO:0051059NF-kappaB binding IPI--
         
    Find genes that share ontologies with SETD6           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Setd6 (no phenotypes)

    Find genes that share phenotypes with SETD6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Setd6tm1(KOMP)Mbp for SETD6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SETD6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SETD6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SETD6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SETD6

    miRNA
    Products:
        
    miRTarBase miRNAs that target SETD6:
    hsa-mir-484 (MIRT042072)

    Block miRNA regulation of human, mouse, rat SETD6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SETD6 (see all 49):
    hsa-miR-411* hsa-miR-2052 hsa-miR-4307 hsa-miR-379* hsa-miR-199a-3p hsa-miR-15a hsa-miR-503 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidSETD6 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SETD6

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SETD6 (NM_024860)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SETD6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SETD6_HUMAN, Q8TBK2: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with SETD6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including SETD6: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SETD6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for SETD6 (Q8TBK21, 3 ENSP000003100824) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    KPNB1ENSP000002901584STRING: ENSP00000290158
    FBXO18ENSP000003693354STRING: ENSP00000369335
    RAD52ENSP000003512844STRING: ENSP00000351284
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018026peptidyl-lysine monomethylation IDA--
    GO:0032088negative regulation of NF-kappaB transcription factor activity IMP--
    GO:0050727regulation of inflammatory response IMP--

    Find genes that share ontologies with SETD6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SETD6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SETD6 gene (2 alternative transcripts): 
    NM_001160305.1  NM_024860.2  

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310682 ENST00000394266(uc002enr.3 uc002ens.3 uc010cdm.3)
    ENST00000219315(uc010vij.1 uc010cdl.2) ENST00000427443(uc021tjh.1)
    ENST00000470003 ENST00000492050 ENST00000447443 ENST00000468223 ENST00000418480
    ENST00000422445 ENST00000467320 ENST00000463954 ENST00000491587
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SETD6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SETD6 (see all 49):
    hsa-miR-411* hsa-miR-2052 hsa-miR-4307 hsa-miR-379* hsa-miR-199a-3p hsa-miR-15a hsa-miR-503 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidSETD6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SETD6
    Predesigned siRNA for gene silencing in human, mouse, rat SETD6
    Clone
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    OriGene clones in human, mouse for SETD6 (see all 13)
    OriGene ORF clones in mouse, rat for SETD6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SETD6 (NM_024860)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SETD6
    OriGene qSTAR qPCR primer pairs in human, mouse for SETD6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SETD6
      QuantiTect SYBR Green Assays in human, mouse, rat SETD6
      QuantiFast Probe-based Assays in human, mouse, rat SETD6

    Selected AceView cDNA sequences (see all 119):

    BG150157 AW294517 CR616142 BF981196 BM792634 BU677517 BM353722 BM053078 
    BQ428163 AI683799 BQ776520 BM353451 BM968443 BM823415 BG924338 BC022451 
    CK002963 AW439917 BG760858 BI669009 BM052780 BE549562 AI652179 BQ057751 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SETD6 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d · 10e
    SP1:                    -                             -                       -     -                                                   
    SP2:                                                  -                       -     -                                                   
    SP3:                          -                                                                                                         
    SP4:                    -                                                                                                               
    SP5:                                                  -     -     -     -     -     -     -     -                                       


    ECgene alternative splicing isoforms for SETD6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SETD6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SETD6 Expression
    About this image

    SETD6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SETD6 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including SETD6: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SETD6
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SETD6
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    QuantiFast Probe-based Assays in human, mouse, rat SETD6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SETD6 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Setd61 , 5 SET domain containing 61, 5 83.93(n)1
    82.37(a)1
      8 (47.17 cM)5
    660831  NM_001035123.31  NP_001030295.11 
     957159155 
    chicken
    (Gallus gallus)
    Aves SETD61 SET domain containing 6 71.41(n)
    68.62(a)
      101750922  XM_004944108.1  XP_004944165.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    63(a)
    59(a)
    many → 1
    many → 1
    AAWZ02039808(564-6894)
    AAWZ02038141(1691-12879)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.13972 Xenopus laevis transcribed sequence with weak similarity more 74.73(n)    CD098703.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb58f112 wufb58f11 71.89(n)   322348  BC044440.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RKM4(YDR257C)4 Ribosomal lysine methyltransferase specific for monomethylation more   --   4(971474-969990) 851844  NP_010543.1 


    ENSEMBL Gene Tree for SETD6 (if available)
    TreeFam Gene Tree for SETD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SETD6 gene

    Find genes that share paralogs with SETD6           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SETD6
    PGOHUM00000240242


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SETD6 (see all 221)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378801051,2
    --58548152(+) CCTCAC/TAAGAT 2 -- us2k10--------
    rs1423114911,2
    --58548169(+) TGGGCC/TACAGG 2 -- us2k10--------
    rs1138534121,2
    F--58548203(+) GGCTTC/TTAAAT 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs777599181,2
    C--58548362(+) CAGGC-/CGCGCG
            
    CGGTG
    2 -- us2k10--------
    rs1916604831,2
    C--58548387(+) TGTAAA/TCCTAG 2 -- us2k10--------
    rs355563131,2
    C,F--58548415(+) GCGGGG/AGGATT 2 -- us2k12Minor allele frequency- A:0.50NA 4
    rs2005168521,2
    C--58548670(+) AAAAAA/GGAAAA 2 -- us2k10--------
    rs2003943321,2
    C--58548672(+) AAAGG-/AAAAAAA 2 -- us2k10--------
    rs740231141,2
    C,F--58548847(+) TCCCTA/TCTATG 2 -- us2k12Minor allele frequency- T:0.09WA 120
    rs1837933231,2
    --58548913(+) GGCAAA/GTAAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SETD6 (58549383 - 58554431 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SETD6:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2876n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SETD6
    DNA2.0 Custom Variant and Variant Library Synthesis for SETD6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SETD6 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SETD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling. (PubMed id 21131967)1, 2 Levy D.... Gozani O. (Nat. Immunol. 2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. (PubMed id 23324626)1 Binda O....Richard S. (Epigenetics 2013)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. (PubMed id 21515635)1 Chang Y....Cheng X. (Nucleic Acids Res. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. (PubMed id 19416867)1 Kim Y.C....Wang S.M. (Proc. Natl. Acad. Sci. U.S.A. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79918 HGNC: 26116 AceView: FLJ21148 Ensembl:ENSG00000103037 euGenes: HUgn79918
    ECgene: SETD6 H-InvDB: SETD6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SETD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SETD6 gene:
    Search GeneIP for patents involving SETD6

    GeneCards and IP:
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