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Aliases for SETD6 Gene

Aliases for SETD6 Gene

  • SET Domain Containing 6 2 3
  • SET Domain-Containing Protein 6 4
  • EC 2.1.1.- 4

External Ids for SETD6 Gene

Previous GeneCards Identifiers for SETD6 Gene

  • GC16P057107
  • GC16P058549
  • GC16P044417

Summaries for SETD6 Gene

GeneCards Summary for SETD6 Gene

SETD6 (SET Domain Containing 6) is a Protein Coding gene. GO annotations related to this gene include NF-kappaB binding and protein-lysine N-methyltransferase activity.

UniProtKB/Swiss-Prot for SETD6 Gene

  • Protein-lysine N-methyltransferase. Monomethylates Lys-310 of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity (PubMed:21131967). Monomethylates Lys-8 of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SETD6 Gene

Genomics for SETD6 Gene

Regulatory Elements for SETD6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SETD6 Gene

Chromosome:
16
Start:
58,515,479 bp from pter
End:
58,521,181 bp from pter
Size:
5,703 bases
Orientation:
Plus strand

Genomic View for SETD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SETD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SETD6 Gene

Proteins for SETD6 Gene

  • Protein details for SETD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBK2-SETD6_HUMAN
    Recommended name:
    N-lysine methyltransferase SETD6
    Protein Accession:
    Q8TBK2
    Secondary Accessions:
    • A8K380
    • B5ME38
    • Q9H787

    Protein attributes for SETD6 Gene

    Size:
    473 amino acids
    Molecular mass:
    53189 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SETD6 Gene

    Alternative splice isoforms for SETD6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SETD6 Gene

Proteomics data for SETD6 Gene at MOPED

Post-translational modifications for SETD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SETD6 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SETD6

No data available for DME Specific Peptides for SETD6 Gene

Domains & Families for SETD6 Gene

Protein Domains for SETD6 Gene

Suggested Antigen Peptide Sequences for SETD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBK2

UniProtKB/Swiss-Prot:

SETD6_HUMAN :
  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
Domain:
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
genes like me logo Genes that share domains with SETD6: view

No data available for Gene Families for SETD6 Gene

Function for SETD6 Gene

Molecular function for SETD6 Gene

UniProtKB/Swiss-Prot Function:
Protein-lysine N-methyltransferase. Monomethylates Lys-310 of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity (PubMed:21131967). Monomethylates Lys-8 of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity).

Enzyme Numbers (IUBMB) for SETD6 Gene

Gene Ontology (GO) - Molecular Function for SETD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21131967
GO:0016279 protein-lysine N-methyltransferase activity IDA 21131967
GO:0051059 NF-kappaB binding IPI 21131967
genes like me logo Genes that share ontologies with SETD6: view

Phenotypes for SETD6 Gene

GenomeRNAi human phenotypes for SETD6:
genes like me logo Genes that share phenotypes with SETD6: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SETD6

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SETD6 Gene

Localization for SETD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SETD6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SETD6 Gene COMPARTMENTS Subcellular localization image for SETD6 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SETD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21131967
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SETD6: view

Pathways & Interactions for SETD6 Gene

SuperPathways for SETD6 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SETD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018026 peptidyl-lysine monomethylation IDA 21131967
GO:0019827 stem cell population maintenance ISS --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP 21131967
GO:0034968 histone lysine methylation IDA 23324626
GO:0048863 stem cell differentiation ISS --
genes like me logo Genes that share ontologies with SETD6: view

No data available for Pathways by source and SIGNOR curated interactions for SETD6 Gene

Drugs & Compounds for SETD6 Gene

No Compound Related Data Available

Transcripts for SETD6 Gene

Unigene Clusters for SETD6 Gene

SET domain containing 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SETD6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SETD6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5: - - - - - - - -
SP6:
SP7:
SP8:

Relevant External Links for SETD6 Gene

GeneLoc Exon Structure for
SETD6
ECgene alternative splicing isoforms for
SETD6

Expression for SETD6 Gene

mRNA expression in normal human tissues for SETD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SETD6 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SETD6 Gene



SOURCE GeneReport for Unigene cluster for SETD6 Gene Hs.731691

genes like me logo Genes that share expression patterns with SETD6: view

Protein tissue co-expression partners for SETD6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SETD6 Gene

Orthologs for SETD6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SETD6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SETD6 35
  • 89.55 (n)
  • 89.8 (a)
SETD6 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SETD6 35
  • 89.51 (n)
  • 90.11 (a)
SETD6 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Setd6 35
  • 83.93 (n)
  • 82.37 (a)
Setd6 16
Setd6 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SETD6 35
  • 99.18 (n)
  • 98.89 (a)
SETD6 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Setd6 35
  • 83.41 (n)
  • 83.26 (a)
oppossum
(Monodelphis domestica)
Mammalia SETD6 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SETD6 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SETD6 35
  • 71.41 (n)
  • 68.62 (a)
-- 36
  • 64 (a)
OneToMany
SETD6 36
  • 68 (a)
OneToMany
SETD6 36
  • 68 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia setd6 35
  • 59.9 (n)
  • 56.7 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1397 35
zebrafish
(Danio rerio)
Actinopterygii setd6 35
  • 56.58 (n)
  • 50.67 (a)
wufb58f11 35
setd6 36
  • 47 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7724 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RKM4 36
  • 21 (a)
OneToOne
RKM4 38
bread mold
(Neurospora crassa)
Ascomycetes NCU09827 35
  • 44.21 (n)
  • 30.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for SETD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SETD6 Gene

ENSEMBL:
Gene Tree for SETD6 (if available)
TreeFam:
Gene Tree for SETD6 (if available)

Paralogs for SETD6 Gene

Pseudogenes.org Pseudogenes for SETD6 Gene

genes like me logo Genes that share paralogs with SETD6: view

No data available for Paralogs for SETD6 Gene

Variants for SETD6 Gene

Sequence variations from dbSNP and Humsavar for SETD6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3607 -- 58,519,017(-) GTCAG(C/T)TCCAA synonymous-codon, reference, nc-transcript-variant
rs37034 -- 58,517,456(-) AAAGT(C/G)GGAAA intron-variant
rs37035 -- 58,519,260(-) AAACA(A/C/G/T)CTGTA utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs37036 -- 58,519,444(-) CGAGT(A/G)CCAGT utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs1060858 -- 58,518,779(+) AGGGG(A/G)AGATG missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SETD6 Gene

Variant ID Type Subtype PubMed ID
dgv2876n71 CNV Loss 21882294

Variation tolerance for SETD6 Gene

Residual Variation Intolerance Score: 32.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SETD6 Gene

HapMap Linkage Disequilibrium report
SETD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SETD6 Gene

Disorders for SETD6 Gene

Relevant External Links for SETD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SETD6
genes like me logo Genes that share disorders with SETD6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SETD6 Gene

Publications for SETD6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. SETD6 controls the expression of estrogen-responsive genes and proliferation of breast carcinoma cells. (PMID: 24751716) O'Neill D.J. … Binda O. (Epigenetics 2014) 67
  3. SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. (PMID: 23324626) Binda O. … Richard S. (Epigenetics 2013) 67
  4. Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling. (PMID: 21131967) Levy D. … Gozani O. (Nat. Immunol. 2011) 67
  5. Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. (PMID: 21515635) Chang Y. … Cheng X. (Nucleic Acids Res. 2011) 67

Products for SETD6 Gene

Sources for SETD6 Gene

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