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Aliases for SETD6 Gene

Aliases for SETD6 Gene

  • SET Domain Containing 6 2 3
  • SET Domain-Containing Protein 6 4
  • EC 2.1.1.- 4

External Ids for SETD6 Gene

Summaries for SETD6 Gene

GeneCards Summary for SETD6 Gene

SETD6 (SET Domain Containing 6) is a Protein Coding gene. GO annotations related to this gene include NF-kappaB binding and protein-lysine N-methyltransferase activity.

UniProtKB/Swiss-Prot for SETD6 Gene

  • Protein-lysine N-methyltransferase that specifically monomethylates Lys-310 of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SETD6 Gene

Genomics for SETD6 Gene

Genomic Location for SETD6 Gene

58,514,781 bp from pter
58,521,181 bp from pter
6,401 bases
Plus strand

Genomic View for SETD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SETD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SETD6 Gene

Regulatory Elements for SETD6 Gene

Proteins for SETD6 Gene

  • Protein details for SETD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-lysine methyltransferase SETD6
    Protein Accession:
    Secondary Accessions:
    • A8K380
    • B5ME38
    • Q9H787

    Protein attributes for SETD6 Gene

    473 amino acids
    Molecular mass:
    53189 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SETD6 Gene

    Alternative splice isoforms for SETD6 Gene


neXtProt entry for SETD6 Gene

Proteomics data for SETD6 Gene at MOPED

Post-translational modifications for SETD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SETD6 Gene

No data available for DME Specific Peptides for SETD6 Gene

Domains for SETD6 Gene

Protein Domains for SETD6 Gene


  • Contains 1 SET domain.:
    • Q8TBK2
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.:
    • Q8TBK2
genes like me logo Genes that share domains with SETD6: view

No data available for Gene Families for SETD6 Gene

Function for SETD6 Gene

Molecular function for SETD6 Gene

UniProtKB/Swiss-Prot Function: Protein-lysine N-methyltransferase that specifically monomethylates Lys-310 of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity.

Enzyme Numbers (IUBMB) for SETD6 Gene

Gene Ontology (GO) - Molecular Function for SETD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21131967
GO:0016279 protein-lysine N-methyltransferase activity IDA 21131967
GO:0051059 NF-kappaB binding IPI 21131967
genes like me logo Genes that share ontologies with SETD6: view

miRNA for SETD6 Gene

miRTarBase miRNAs that target SETD6

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SETD6 Gene

Localization for SETD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SETD6 Gene

Subcellular locations from

Jensen Localization Image for SETD6 Gene COMPARTMENTS Subcellular localization image for SETD6 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SETD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SETD6: view

Pathways for SETD6 Gene

SuperPathways for SETD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SETD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018026 peptidyl-lysine monomethylation IDA 21131967
GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP 21131967
GO:0050727 regulation of inflammatory response IMP 21131967
genes like me logo Genes that share ontologies with SETD6: view

No data available for Pathways by source for SETD6 Gene

Transcripts for SETD6 Gene

Unigene Clusters for SETD6 Gene

SET domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SETD6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5: - - - - - - - -

Relevant External Links for SETD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SETD6 Gene

mRNA expression in normal human tissues for SETD6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SETD6 Gene

SOURCE GeneReport for Unigene cluster for SETD6 Gene Hs.731691

genes like me logo Genes that share expressions with SETD6: view

Orthologs for SETD6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SETD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SETD6 36
  • 99.18 (n)
  • 98.89 (a)
SETD6 37
  • 98 (a)
(Bos Taurus)
Mammalia SETD6 36
  • 89.55 (n)
  • 89.8 (a)
SETD6 37
  • 88 (a)
(Canis familiaris)
Mammalia SETD6 36
  • 89.51 (n)
  • 90.11 (a)
SETD6 37
  • 84 (a)
(Mus musculus)
Mammalia Setd6 36
  • 83.93 (n)
  • 82.37 (a)
Setd6 16
Setd6 37
  • 78 (a)
(Monodelphis domestica)
Mammalia SETD6 37
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia SETD6 37
  • 68 (a)
(Rattus norvegicus)
Mammalia Setd6 36
  • 83.41 (n)
  • 83.26 (a)
(Gallus gallus)
Aves -- 37
  • 64 (a)
SETD6 36
  • 71.41 (n)
  • 68.62 (a)
SETD6 37
  • 68 (a)
SETD6 37
  • 68 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 59 (a)
-- 37
  • 63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1397 36
tropical clawed frog
(Silurana tropicalis)
Amphibia setd6 36
  • 59.9 (n)
  • 56.7 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7724 36
(Danio rerio)
Actinopterygii setd6 36
  • 56.58 (n)
  • 50.67 (a)
setd6 37
  • 47 (a)
wufb58f11 36
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RKM4 37
  • 21 (a)
RKM4 39
bread mold
(Neurospora crassa)
Ascomycetes NCU09827 36
  • 44.21 (n)
  • 30.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 31 (a)
Species with no ortholog for SETD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SETD6 Gene

Gene Tree for SETD6 (if available)
Gene Tree for SETD6 (if available)

Paralogs for SETD6 Gene Pseudogenes for SETD6 Gene

genes like me logo Genes that share paralogs with SETD6: view

No data available for Paralogs for SETD6 Gene

Variants for SETD6 Gene

Sequence variations from dbSNP and Humsavar for SETD6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3607 -- 58,519,017(-) GTCAG(C/T)TCCAA synonymous-codon, reference, nc-transcript-variant
rs37034 -- 58,517,456(-) AAAGT(C/G)GGAAA intron-variant
rs37035 -- 58,519,260(-) AAACA(A/C/G/T)CTGTA utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs37036 -- 58,519,444(-) CGAGT(A/G)CCAGT utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs1060858 -- 58,518,779(+) AGGGG(A/G)AGATG missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SETD6 Gene

Variant ID Type Subtype PubMed ID
dgv2876n71 CNV Loss 21882294

Relevant External Links for SETD6 Gene

HapMap Linkage Disequilibrium report

Disorders for SETD6 Gene

No disorders were found for SETD6 Gene.

No data available for UniProtKB/Swiss-Prot for SETD6 Gene

Publications for SETD6 Gene

  1. Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling. (PMID: 21131967) Levy D. … Gozani O. (Nat. Immunol. 2011) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for SETD6 Gene

Sources for SETD6 Gene

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