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Aliases for SETD4 Gene

Aliases for SETD4 Gene

  • SET Domain Containing 4 2 3
  • C21orf18 3 4
  • C21orf27 3 4
  • Chromosome 21 Open Reading Frame 27 2
  • Chromosome 21 Open Reading Frame 18 2
  • SET Domain-Containing Protein 4 3
  • EC 2.1.1.- 4

External Ids for SETD4 Gene

Previous HGNC Symbols for SETD4 Gene

  • C21orf27
  • C21orf18

Previous GeneCards Identifiers for SETD4 Gene

  • GC21M036329
  • GC21M037406
  • GC21M022885

Summaries for SETD4 Gene

GeneCards Summary for SETD4 Gene

SETD4 (SET Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is SETD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SETD4 Gene

Genomics for SETD4 Gene

Regulatory Elements for SETD4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SETD4 Gene

Start:
36,034,541 bp from pter
End:
36,079,389 bp from pter
Size:
44,849 bases
Orientation:
Minus strand

Genomic View for SETD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SETD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SETD4 Gene

Proteins for SETD4 Gene

  • Protein details for SETD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVD3-SETD4_HUMAN
    Recommended name:
    SET domain-containing protein 4
    Protein Accession:
    Q9NVD3
    Secondary Accessions:
    • B4DT14
    • D3DSG2
    • D3DSG4
    • Q8NE19
    • Q9BU46

    Protein attributes for SETD4 Gene

    Size:
    440 amino acids
    Molecular mass:
    50416 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SETD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SETD4 Gene

Proteomics data for SETD4 Gene at MOPED

Post-translational modifications for SETD4 Gene

  • Ubiquitination at Lys127
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SETD4 Gene

Domains for SETD4 Gene

Protein Domains for SETD4 Gene

Suggested Antigen Peptide Sequences for SETD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVD3

UniProtKB/Swiss-Prot:

SETD4_HUMAN :
  • Q9NVD3
Domain:
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
genes like me logo Genes that share domains with SETD4: view

No data available for Gene Families for SETD4 Gene

Function for SETD4 Gene

Enzyme Numbers (IUBMB) for SETD4 Gene

Gene Ontology (GO) - Molecular Function for SETD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with SETD4: view

Phenotypes for SETD4 Gene

GenomeRNAi human phenotypes for SETD4:
genes like me logo Genes that share phenotypes with SETD4: view

Animal Model Products

CRISPR Products

miRNA for SETD4 Gene

miRTarBase miRNAs that target SETD4

No data available for Molecular function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SETD4 Gene

Localization for SETD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SETD4 Gene COMPARTMENTS Subcellular localization image for SETD4 gene
Compartment Confidence
nucleus 2
cytoskeleton 1
cytosol 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SETD4 Gene

Pathways for SETD4 Gene

SuperPathways for SETD4 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SETD4 Gene

Gene Ontology (GO) - Biological Process for SETD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with SETD4: view

No data available for Pathways by source for SETD4 Gene

Transcripts for SETD4 Gene

Unigene Clusters for SETD4 Gene

SET domain containing 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SETD4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SETD4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - -
SP10: - - - - -
SP11: -
SP12:
SP13: -
SP14:

ExUns: 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SETD4 Gene

GeneLoc Exon Structure for
SETD4
ECgene alternative splicing isoforms for
SETD4

Expression for SETD4 Gene

mRNA expression in normal human tissues for SETD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for SETD4 Gene Hs.606200

genes like me logo Genes that share expressions with SETD4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for SETD4 Gene

Orthologs for SETD4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SETD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SETD4 35
  • 99.55 (n)
  • 99.77 (a)
SETD4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SETD4 35
  • 84.47 (n)
  • 81.14 (a)
SETD4 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SETD4 35
  • 87.4 (n)
  • 84.74 (a)
SETD4 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Setd4 35
  • 78.28 (n)
  • 76.99 (a)
Setd4 16
Setd4 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SETD4 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SETD4 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Setd4 35
  • 78.16 (n)
  • 76.85 (a)
chicken
(Gallus gallus)
Aves SETD4 35
  • 67.51 (n)
  • 63.84 (a)
SETD4 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SETD4 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53706 35
tropical clawed frog
(Silurana tropicalis)
Amphibia setd4 35
  • 58.07 (n)
  • 55.02 (a)
zebrafish
(Danio rerio)
Actinopterygii setd4 35
  • 55.37 (n)
  • 49.53 (a)
setd4 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013401 35
  • 42.24 (n)
  • 31.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33230 35
  • 41.96 (n)
  • 30.07 (a)
CG33230 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea set-29 35
  • 42.97 (n)
  • 31.08 (a)
set-29 36
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EFM1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToOne
Species with no ortholog for SETD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SETD4 Gene

ENSEMBL:
Gene Tree for SETD4 (if available)
TreeFam:
Gene Tree for SETD4 (if available)

Paralogs for SETD4 Gene

Paralogs for SETD4 Gene

genes like me logo Genes that share paralogs with SETD4: view

Variants for SETD4 Gene

Sequence variations from dbSNP and Humsavar for SETD4 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs8738 -- 36,048,352(-) CTCAC(C/T)ACGGA reference, synonymous-codon, intron-variant, nc-transcript-variant
rs743422 -- 36,034,380(+) GATTG(G/T)GGGGC downstream-variant-500B
rs762360 -- 36,053,657(+) CCTAC(C/T)ATAAC intron-variant
rs762361 -- 36,053,673(+) GGTCC(C/T)AGAGA intron-variant
rs762364 -- 36,034,551(+) TCTGC(A/C/G)AAGTT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SETD4 Gene

Variant ID Type Subtype PubMed ID
nsv913730 CNV Gain 21882294
nsv470899 CNV Loss 18288195
nsv459247 CNV Loss 19166990
nsv3504 CNV Insertion 18451855
esv2665899 CNV Deletion 23128226
esv2723388 CNV Deletion 23290073
esv2723389 CNV Deletion 23290073
esv1004462 CNV Deletion 20482838

Relevant External Links for SETD4 Gene

HapMap Linkage Disequilibrium report
SETD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SETD4 Gene

Disorders for SETD4 Gene

No disorders were found for SETD4 Gene.

No data available for UniProtKB/Swiss-Prot for SETD4 Gene

Publications for SETD4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  5. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A. … Antonarakis S.E. (Genomics 2001) 3 4

Products for SETD4 Gene

Sources for SETD4 Gene

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