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Aliases for SETD4 Gene

Aliases for SETD4 Gene

  • SET Domain Containing 4 2 3 5
  • C21orf18 3 4
  • C21orf27 3 4
  • Chromosome 21 Open Reading Frame 27 2
  • Chromosome 21 Open Reading Frame 18 2
  • EC 2.1.1.- 4

External Ids for SETD4 Gene

Previous HGNC Symbols for SETD4 Gene

  • C21orf27
  • C21orf18

Previous GeneCards Identifiers for SETD4 Gene

  • GC21M036329
  • GC21M037406
  • GC21M022885

Summaries for SETD4 Gene

GeneCards Summary for SETD4 Gene

SETD4 (SET Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is SETD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SETD4 Gene

Genomics for SETD4 Gene

Regulatory Elements for SETD4 Gene

Genomic Location for SETD4 Gene

Chromosome:
21
Start:
36,034,541 bp from pter
End:
36,079,389 bp from pter
Size:
44,849 bases
Orientation:
Minus strand

Genomic View for SETD4 Gene

Genes around SETD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SETD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SETD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SETD4 Gene

Proteins for SETD4 Gene

  • Protein details for SETD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVD3-SETD4_HUMAN
    Recommended name:
    SET domain-containing protein 4
    Protein Accession:
    Q9NVD3
    Secondary Accessions:
    • B4DT14
    • D3DSG2
    • D3DSG4
    • Q8NE19
    • Q9BU46

    Protein attributes for SETD4 Gene

    Size:
    440 amino acids
    Molecular mass:
    50416 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SETD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SETD4 Gene

Proteomics data for SETD4 Gene at MOPED

Post-translational modifications for SETD4 Gene

  • Ubiquitination at Lys 127
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SETD4 Gene

Domains & Families for SETD4 Gene

Protein Domains for SETD4 Gene

Suggested Antigen Peptide Sequences for SETD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVD3

UniProtKB/Swiss-Prot:

SETD4_HUMAN :
  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
Domain:
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
genes like me logo Genes that share domains with SETD4: view

No data available for Gene Families for SETD4 Gene

Function for SETD4 Gene

Enzyme Numbers (IUBMB) for SETD4 Gene

genes like me logo Genes that share phenotypes with SETD4: view

Animal Models for SETD4 Gene

MGI Knock Outs for SETD4:

Animal Model Products

miRNA for SETD4 Gene

miRTarBase miRNAs that target SETD4

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SETD4 Gene

Localization for SETD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SETD4 Gene COMPARTMENTS Subcellular localization image for SETD4 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SETD4 Gene

Pathways & Interactions for SETD4 Gene

SuperPathways for SETD4 Gene

No Data Available

Interacting Proteins for SETD4 Gene

Gene Ontology (GO) - Biological Process for SETD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018026 peptidyl-lysine monomethylation IBA --
genes like me logo Genes that share ontologies with SETD4: view

No data available for Pathways by source and SIGNOR curated interactions for SETD4 Gene

Drugs & Compounds for SETD4 Gene

No Compound Related Data Available

Transcripts for SETD4 Gene

Unigene Clusters for SETD4 Gene

SET domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SETD4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - -
SP10: - - - - -
SP11: -
SP12:
SP13: -
SP14:

ExUns: 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SETD4 Gene

GeneLoc Exon Structure for
SETD4
ECgene alternative splicing isoforms for
SETD4

Expression for SETD4 Gene

mRNA expression in normal human tissues for SETD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for SETD4 Gene Hs.606200

genes like me logo Genes that share expression patterns with SETD4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SETD4 Gene

Orthologs for SETD4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SETD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SETD4 35
  • 99.55 (n)
  • 99.77 (a)
SETD4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SETD4 36
  • 81 (a)
OneToOne
SETD4 35
  • 84.47 (n)
  • 81.14 (a)
dog
(Canis familiaris)
Mammalia SETD4 35
  • 87.4 (n)
  • 84.74 (a)
SETD4 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Setd4 36
  • 77 (a)
OneToOne
Setd4 16
Setd4 35
  • 78.28 (n)
  • 76.99 (a)
oppossum
(Monodelphis domestica)
Mammalia SETD4 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SETD4 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Setd4 35
  • 78.16 (n)
  • 76.85 (a)
chicken
(Gallus gallus)
Aves SETD4 36
  • 64 (a)
OneToOne
SETD4 35
  • 67.51 (n)
  • 63.84 (a)
lizard
(Anolis carolinensis)
Reptilia SETD4 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53706 35
tropical clawed frog
(Silurana tropicalis)
Amphibia setd4 35
  • 58.07 (n)
  • 55.02 (a)
zebrafish
(Danio rerio)
Actinopterygii setd4 36
  • 48 (a)
OneToOne
setd4 35
  • 55.37 (n)
  • 49.53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013401 35
  • 42.24 (n)
  • 31.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33230 36
  • 21 (a)
OneToOne
CG33230 35
  • 41.96 (n)
  • 30.07 (a)
worm
(Caenorhabditis elegans)
Secernentea set-29 35
  • 42.97 (n)
  • 31.08 (a)
set-29 36
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EFM1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToOne
Species with no ortholog for SETD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SETD4 Gene

ENSEMBL:
Gene Tree for SETD4 (if available)
TreeFam:
Gene Tree for SETD4 (if available)

Paralogs for SETD4 Gene

Paralogs for SETD4 Gene

genes like me logo Genes that share paralogs with SETD4: view

Variants for SETD4 Gene

Sequence variations from dbSNP and Humsavar for SETD4 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2835239 - 36,038,179(+) TTCTA(C/T)GAAAT nc-transcript-variant, reference, missense
VAR_035988 A colorectal cancer sample
rs743422 -- 36,034,380(+) GATTG(G/T)GGGGC downstream-variant-500B
rs762360 -- 36,053,657(+) CCTAC(C/T)ATAAC intron-variant
rs762361 -- 36,053,673(+) GGTCC(C/T)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SETD4 Gene

Variant ID Type Subtype PubMed ID
nsv913730 CNV Gain 21882294
nsv470899 CNV Loss 18288195
nsv459247 CNV Loss 19166990
nsv3504 CNV Insertion 18451855
esv2665899 CNV Deletion 23128226
esv2723388 CNV Deletion 23290073
esv2723389 CNV Deletion 23290073
esv1004462 CNV Deletion 20482838

Variation tolerance for SETD4 Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SETD4 Gene

HapMap Linkage Disequilibrium report
SETD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SETD4 Gene

Disorders for SETD4 Gene

Relevant External Links for SETD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SETD4

No disorders were found for SETD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SETD4 Gene

Publications for SETD4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SETD4 Gene

Sources for SETD4 Gene

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