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SETD4 Gene

protein-coding   GIFtS: 48
GCID: GC21M037406

SET Domain Containing 4

(Previous names: chromosome 21 open reading frame 27, chromosome 21 open...)
(Previous symbols: C21orf27, C21orf18)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SET Domain Containing 41 2     Chromosome 21 Open Reading Frame 271
C21orf181 2 3     SET Domain-Containing Protein 42
C21orf271 2 3     EC 2.1.1.-3
Chromosome 21 Open Reading Frame 181     

External Ids:    HGNC: 12581   Entrez Gene: 540932   Ensembl: ENSG000001859177   UniProtKB: Q9NVD33   

Export aliases for SETD4 gene to outside databases

Previous GC identifers: GC21M036329 GC21M022885


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SETD4 Gene:
SETD4 (SET domain containing 4) is a protein-coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is SETD3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SETD4 gene promoter:
         Max   FOXD3   ARP-1   Ik-3   NF-E2 p45   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SETD4 promoter sequence
   Search Chromatin IP Primers for SETD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SETD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.13   Ensembl cytogenetic band:  21q22.12   HGNC cytogenetic band: 21q22.13

SETD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETD4 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M037406:  view genomic region     (about GC identifiers)

Start:
37,406,839 bp from pter      End:
37,451,687 bp from pter
Size:
44,849 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for SETD4

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SETD4_HUMAN, Q9NVD3 (See protein sequence)
Recommended Name: SET domain-containing protein 4  
Size: 440 amino acids; 50416 Da
Secondary accessions: B4DT14 D3DSG2 D3DSG4 Q8NE19 Q9BU46
Alternative splicing: 3 isoforms:  Q9NVD3-1   Q9NVD3-2   Q9NVD3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SETD4: NX_Q9NVD3

Explore proteomics data for SETD4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys127
  • Modification sites at PhosphoSitePlus

  • See SETD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001007260.1  NP_001007262.1  NP_001273681.1  NP_059134.1  

    ENSEMBL proteins: 
     ENSP00000382163   ENSP00000382161   ENSP00000329189   ENSP00000382156   ENSP00000382159  
     ENSP00000382152   ENSP00000382158   ENSP00000399998   ENSP00000396837   ENSP00000413318  
     ENSP00000394822   ENSP00000392463  

    SETD4 Human Recombinant Protein Products:

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    Novus Biologicals SETD4 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SETD4

     
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    antibodies-online proteins for SETD4 (3 products) 

     
    antibodies-online peptides for SETD4

    SETD4 Antibody Products:

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    antibodies-online antibodies for SETD4 (16 products) 

    SETD4 Assay Products:

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    Cloud-Clone Corp. ELISAs for SETD4
    Cloud-Clone Corp. CLIAs for SETD4
    Search eBioscience for ELISAs for SETD4 
    antibodies-online kits for SETD4 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001214 SET_dom
     IPR015353 Rubisco_LSMT_subst-bd
     IPR016852 Lys_MTase_YDR198C_prd

    Graphical View of Domain Structure for InterPro Entry Q9NVD3

    ProtoNet protein and cluster: Q9NVD3

    1 Blocks protein domain: IPB001214 Nuclear protein SET

    UniProtKB/Swiss-Prot: SETD4_HUMAN, Q9NVD3
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily
    Similarity: Contains 1 SET domain


    Find genes that share domains with SETD4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008168methyltransferase activity IEA--
         
    Find genes that share ontologies with SETD4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SETD4:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SETD4

    miRNA
    Products:
        
    miRTarBase miRNAs that target SETD4:
    hsa-mir-346 (MIRT004226), hsa-let-7a-3p (MIRT038999), hsa-mir-192-5p (MIRT004168)

    Block miRNA regulation of human, mouse, rat SETD4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SETD4
    SwitchGear 3'UTR luciferase reporter plasmidSETD4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SETD4
    Predesigned siRNA for gene silencing in human, mouse, rat SETD4

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SETD4 (see all 12)
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    GenScript: all cDNA clones in your preferred vector (see all 2): SETD4 (NM_017438)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD4

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SETD4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytoskeleton1
    cytosol1
    mitochondrion1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including SETD4: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SETD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for SETD4 (ENSP000003291894) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCCIPENSP000003577484STRING: ENSP00000357748
    GAPDHENSP000002292394STRING: ENSP00000229239
    GAPDHSENSP000002222864STRING: ENSP00000222286
    PFDN5ENSP000003341884STRING: ENSP00000334188
    RPL23ENSP000003778654STRING: ENSP00000377865
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SETD4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SETD4 gene (7 alternative transcripts): 
    NM_001007258.1  NM_001007260.1  NM_001007262.1  NM_001007259.2  NM_001007261.2  NM_001286752.1  NM_017438.4  

    Unigene Cluster for SETD4:

    SET domain containing 4
    Hs.606200  [show with all ESTs]
    Unigene Representative Sequence: AK095215
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399215(uc002yuw.2) ENST00000481477 ENST00000399212(uc002yux.2)
    ENST00000332131(uc021wiy.1 uc002yuu.3) ENST00000487297 ENST00000469482
    ENST00000399205(uc002yuz.3) ENST00000399208(uc002yuy.3) ENST00000399201(uc002yva.3)
    ENST00000399207 ENST00000424303 ENST00000429161 ENST00000485865 ENST00000446166
    ENST00000442559 ENST00000460704 ENST00000443703
    miRNA
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    Block miRNA regulation of human, mouse, rat SETD4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SETD4
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    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SETD4
    Predesigned siRNA for gene silencing in human, mouse, rat SETD4
    Clone
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    OriGene clones in human, mouse for SETD4 (see all 12)
    OriGene ORF clones in mouse, rat for SETD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SETD4 (NM_017438)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD4
    Primer
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    OriGene qPCR primer pairs and template standards for SETD4
    OriGene qSTAR qPCR primer pairs in human, mouse for SETD4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SETD4
      QuantiTect SYBR Green Assays in human, mouse, rat SETD4
      QuantiFast Probe-based Assays in human, mouse, rat SETD4

    Additional mRNA sequence: 

    AB004848.1 AB004849.1 AB004852.1 AB004853.1 AK001660.1 AK095215.1 AK124254.1 AK126368.1 
    AK300009.1 BC002898.2 BC036556.2 NR_040086.1 NR_040087.1 NR_040088.1 

    22 DOTS entries:

    DT.100745178  DT.97775398  DT.212719  DT.101974299  DT.121139261  DT.102829872  DT.121139198  DT.212720 
    DT.456043  DT.101969543  DT.97796067  DT.40285922  DT.86840972  DT.92060555  DT.100741466  DT.102829871 
    DT.121139243  DT.40126427  DT.40223430  DT.100643115  DT.101966741  DT.91997959 

    Selected AceView cDNA sequences (see all 138):

    AA083235 AB004849 BX643841 BQ925201 BC036556 AU132850 AI246570 AA811472 
    AW009965 AA887484 BU076063 AK095215 BM705755 AK001660 BV177463 BE254199 
    AI553961 AF391112 CA778040 AI636385 AA830451 AK126368 AB004853 AB004848 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SETD4 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^
    SP1:                          -     -                       -                 -                                               -     -     -                     
    SP2:                          -     -     -           -     -                 -                                               -     -     -                     
    SP3:                          -     -     -           -     -                 -     -     -                                   -     -     -                     
    SP4:                                -                       -                 -                                                                                 
    SP5:                          -     -     -                 -                 -                                                                                 

    ExUns: 16a · 16b ^ 17
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SETD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SETD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGGCTCC
    SETD4 Expression
    About this image


    SETD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)
             Secondary follicles
    SETD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SETD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.606200
        Pathway & Disease-focused RT2 Profiler PCR Array including SETD4: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat SETD4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SETD4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Setd41 , 5 SET domain containing 41, 5 78.28(n)1
    76.99(a)1
      16 (54.52 cM)5
    2244401  NM_145482.31  NP_663457.21 
     935834575 
    chicken
    (Gallus gallus)
    Aves SETD41 SET domain containing 4 67.51(n)
    63.84(a)
      418511  NM_001030794.2  NP_001025965.1 
    lizard
    (Anolis carolinensis)
    Reptilia SETD46
    SET domain containing 4
    60(a)
    1 ↔ 1
    GL344111.1(22489-43572)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC537062 similar to chromosome 21 open reading frame 18 70.91(n)    BC046855.1 
    zebrafish
    (Danio rerio)
    Actinopterygii setd41 SET domain containing 4 55.37(n)
    49.53(a)
      564058  NM_001045562.1  NP_001039027.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG332301 CG33230 41.96(n)
    30.07(a)
      2768998  NM_206233.2  NP_995955.1 
    worm
    (Caenorhabditis elegans)
    Secernentea set-291 set-29 42.97(n)
    31.08(a)
      171705  NM_058448.5  NP_490849.4 


    ENSEMBL Gene Tree for SETD4 (if available)
    TreeFam Gene Tree for SETD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SETD4 gene
    SETD32  

    Find genes that share paralogs with SETD4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SETD4 (see all 653)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359884
    A colorectal cancer sample4--see VAR_0359882 E G mis40--------
    rs713306331,2
    C,F--37406342(+) TCTTCG/AAATAA 3 -- int1 ds50013Minor allele frequency- A:0.08NA 124
    rs1450291521,2
    --37406399(+) TGCAGA/TTCTGC 3 -- int1 ds50010--------
    rs733704311,2
    C,F--37406543(+) AGCACG/AATCCT 3 -- int1 ds50012Minor allele frequency- A:0.04WA 120
    rs1813185621,2
    --37406647(+) GCTCAC/TTTTTT 3 -- int1 ds50010--------
    rs7434221,2
    C,F,A--37406678(+) GATTGG/TGGGGC 3 -- int1 ds50018Minor allele frequency- T:0.34NA WA CSA EA 368
    rs8786061,2
    C,F,A--37406692(+) GGGACG/ACATTA 3 -- int1 ds50018Minor allele frequency- A:0.27NA WA CSA EA 372
    rs1388703321,2
    --37406753(+) GCCTCC/TCCTGA 3 -- int1 ds50010--------
    rs1143849201,2
    C,F--37406794(+) CCACTG/ACGCAG 3 -- int1 ds50011Minor allele frequency- A:0.02WA 118
    rs7623641,2
    C,F,O,A,H--37406849(+) TCTGCA/GAAGTT 3 -- ut31 nc-transcript-variantese335Minor allele frequency- N:0.00NA EA MN NS WA CSA 3425

    HapMap Linkage Disequilibrium report for SETD4 (37406839 - 37451687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SETD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1004462CNV Deletion20482838
    esv2723388CNV Deletion23290073
    esv2665899CNV Deletion23128226
    esv2723389CNV Deletion23290073
    nsv3504CNV Insertion18451855
    nsv459247CNV Loss19166990
    nsv470899CNV Loss18288195
    nsv913730CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SETD4
    DNA2.0 Custom Variant and Variant Library Synthesis for SETD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SETD4 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with SETD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    4. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PubMed id 11707072)1, 2 Reymond A....Antonarakis S.E. (Genomics 2001)
    5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54093 HGNC: 1258 AceView: C21orf18 Ensembl:ENSG00000185917 euGenes: HUgn54093
    ECgene: SETD4 H-InvDB: SETD4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SETD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SETD4 gene:
    Search GeneIP for patents involving SETD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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