Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SETD4 Gene

protein-coding   GIFtS: 48
GCID: GC21M037406

SET Domain Containing 4

(Previous names: chromosome 21 open reading frame 27, chromosome 21 open...)
(Previous symbols: C21orf27, C21orf18)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
SET Domain Containing 41 2     Chromosome 21 Open Reading Frame 271
C21orf181 2 3     SET Domain-Containing Protein 42
C21orf271 2 3     EC 2.1.1.-3
Chromosome 21 Open Reading Frame 181     

External Ids:    HGNC: 12581   Entrez Gene: 540932   Ensembl: ENSG000001859177   UniProtKB: Q9NVD33   
ORGUL members:         
NONCODE14:n411619 n411618 n411617      

Export aliases for SETD4 gene to outside databases

Previous GC identifers: GC21M036329 GC21M022885


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SETD4 Gene: 
SETD4 (SET domain containing 4) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with SETD4 include down syndrome. An important paralog of this gene is SETD3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SETD4 gene promoter:
         Max   FOXD3   ARP-1   Ik-3   NF-E2 p45   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SETD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SETD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SETD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.13   Ensembl cytogenetic band:  21q22.12   HGNC cytogenetic band: 21q22.13

SETD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETD4 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M037406:  view genomic region     (about GC identifiers)

Start:
37,406,839 bp from pter      End:
37,451,687 bp from pter
Size:
44,849 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for SETD4

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SETD4_HUMAN, Q9NVD3 (See protein sequence)
Recommended Name: SET domain-containing protein 4  
Size: 440 amino acids; 50416 Da
Secondary accessions: B4DT14 D3DSG2 D3DSG4 Q8NE19 Q9BU46
Alternative splicing: 3 isoforms:  Q9NVD3-1   Q9NVD3-2   Q9NVD3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SETD4: NX_Q9NVD3

Explore proteomics data for SETD4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NVD3

  • SETD4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SETD4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001007260.1  NP_059134.1  

    ENSEMBL proteins: 
     ENSP00000382163   ENSP00000382161   ENSP00000329189   ENSP00000382156   ENSP00000382159  
     ENSP00000382152   ENSP00000382158   ENSP00000399998   ENSP00000396837   ENSP00000413318  
     ENSP00000394822   ENSP00000392463  

    Human Recombinant Protein Products for SETD4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SETD4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SETD4
    GenScript Custom Purified and Recombinant Proteins Services for SETD4
    Novus Biologicals SETD4 Protein
    Novus Biologicals SETD4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SETD4 


    SETD4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SETD4
    GenScript Custom Superior Antibodies Services for SETD4
    Novus Biologicals SETD4 Antibodies
    Abcam antibodies for SETD4
    Cloud-Clone Corp. Antibodies for SETD4 
    Search ThermoFisher Antibodies for SETD4
    LSBio Antibodies in human, mouse, rat for SETD4 

    Assay Products for SETD4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SETD4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SETD4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SETD4 
    Cloud-Clone Corp. CLIAs for SETD4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001214 SET_dom
     IPR016852 Lys_MTase_YDR198C_prd
     IPR015353 Rubisco_LSMT_subst-bd

    Graphical View of Domain Structure for InterPro Entry Q9NVD3

    ProtoNet protein and cluster: Q9NVD3

    1 Blocks protein domain: IPB001214 Nuclear protein SET

    UniProtKB/Swiss-Prot: SETD4_HUMAN, Q9NVD3
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily
    Similarity: Contains 1 SET domain


    SETD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008168methyltransferase activity IEA--
         
    SETD4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SETD4:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SETD4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SETD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SETD4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SETD4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SETD4:
    hsa-mir-346 (MIRT004226), hsa-mir-192 (MIRT004168)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SETD4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SETD4
    SwitchGear 3'UTR luciferase reporter plasmidSETD4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SETD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SETD4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SETD4
    Sirion Biotech Customized adenovirus for overexpression of SETD4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SETD4 (see all 14)
    OriGene ORF clones in mouse, rat for SETD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SETD4 (NM_017438)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD4
    Sirion Biotech Customized lentivirus for stable overexpression of SETD4 
                         Customized lentivirus expression plasmids for stable overexpression of SETD4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SETD4
    Search LifeMap BioReagents cell lines for SETD4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SETD4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SETD4 (ENSP000003291894) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SETD4

    Search CenterWatch for drugs/clinical trials and news about SETD4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SETD4 gene (6 alternative transcripts): 
    NM_001007258.1  NM_001007260.1  NM_001007261.1  NM_001007262.1  NM_001007259.1  NM_017438.3  

    Unigene Cluster for SETD4:

    SET domain containing 4
    Hs.606200  [show with all ESTs]
    Unigene Representative Sequence: AK095215
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399215(uc002yuw.2) ENST00000481477 ENST00000399212(uc002yux.2)
    ENST00000332131(uc021wiy.1 uc002yuu.3) ENST00000487297 ENST00000469482
    ENST00000399205(uc002yuz.3) ENST00000399208(uc002yuy.3) ENST00000399201(uc002yva.3)
    ENST00000399207 ENST00000424303 ENST00000429161 ENST00000485865 ENST00000446166
    ENST00000442559 ENST00000460704 ENST00000443703
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SETD4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SETD4
    SwitchGear 3'UTR luciferase reporter plasmidSETD4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SETD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SETD4
    Clone
    Products:
         
    OriGene clones in human, mouse for SETD4 (see all 14)
    OriGene ORF clones in mouse, rat for SETD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SETD4 (NM_017438)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD4
    Sirion Biotech Customized lentivirus for stable overexpression of SETD4 
                         Customized lentivirus expression plasmids for stable overexpression of SETD4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SETD4
    OriGene qSTAR qPCR primer pairs in human, mouse for SETD4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SETD4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SETD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SETD4

    Additional mRNA sequence: 

    AB004848.1 AB004849.1 AB004852.1 AB004853.1 AK001660.1 AK095215.1 AK124254.1 AK126368.1 
    AK300009.1 BC002898.2 BC036556.2 NR_040086.1 NR_040087.1 NR_040088.1 

    22 DOTS entries:

    DT.100745178  DT.97775398  DT.212719  DT.101974299  DT.121139261  DT.102829872  DT.121139198  DT.212720 
    DT.456043  DT.101969543  DT.97796067  DT.40285922  DT.86840972  DT.92060555  DT.100741466  DT.102829871 
    DT.121139243  DT.40126427  DT.40223430  DT.100643115  DT.101966741  DT.91997959 

    24/138 AceView cDNA sequences (see all 138):

    AI246570 AA083235 BV177463 BM705755 AK126368 BU076063 AI796888 BI819114 
    BX643841 BU684569 AB004848 CA778040 BM728275 AW009965 BE254199 BM701705 
    AI553961 NM_017438 R82132 BQ925201 AB004849 AK095215 AI636385 AF391112 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for SETD4 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^
    SP1:                          -     -                       -                 -                                               -     -     -                     
    SP2:                          -     -     -           -     -                 -                                               -     -     -                     
    SP3:                          -     -     -           -     -                 -     -     -                                   -     -     -                     
    SP4:                                -                       -                 -                                                                                 
    SP5:                          -     -     -                 -                 -                                                                                 

    ExUns: 16a · 16b ^ 17
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SETD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SETD4 expression in normal human tissues (normalized intensities)      SETD4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGGCTCC
    SETD4 Expression
    About this image


    SETD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Secondary follicles
             oocyte   
     
     Breast (Uncategorized)
             breast epithelium   
     
     Epithelium
             breast epithelium   

    See SETD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SETD4

    SOURCE GeneReport for Unigene cluster: Hs.606200
        SABiosciences Expression via Pathway-Focused PCR Array including SETD4: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SETD4
    OriGene qSTAR qPCR primer pairs in human, mouse for SETD4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SETD4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SETD4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SETD4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SETD4 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Setd41 , 5 SET domain containing 41, 5 78.28(n)1
    76.99(a)1
      16 (54.52 cM)5
    2244401  NM_145482.31  NP_663457.21 
     935834575 
    chicken
    (Gallus gallus)
    Aves SETD41 SET domain containing 4 67.82(n)
    64.29(a)
      418511  NM_001030794.1  NP_001025965.1 
    lizard
    (Anolis carolinensis)
    Reptilia SETD46
    Uncharacterized protein
    60(a)
    1 ↔ 1
    GL344111.1(22489-43572)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC537062 similar to chromosome 21 open reading frame 18 70.91(n)    BC046855.1 
    zebrafish
    (Danio rerio)
    Actinopterygii setd41 SET domain containing 4 55.3(n)
    49.53(a)
      564058  NM_001045562.1  NP_001039027.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG332301 CG33230 42.31(n)
    30.07(a)
      2768998  NM_206233.1  NP_995955.1 
    worm
    (Caenorhabditis elegans)
    Secernentea set-291 Protein SET-29 43.31(n)
    31.58(a)
      171705  NM_058448.4  NP_490849.4 


    ENSEMBL Gene Tree for SETD4 (if available)
    TreeFam Gene Tree for SETD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SETD4 gene
    SETD32  

    SETD4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/653 SNPs in SETD4 are shown (see all 653)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359884
    A colorectal cancer sample4--see VAR_0359882 E G mis40--------
    rs713306331,2
    C,F--37406342(+) TCTTCG/AAATAA 3 -- int1 ds50013Minor allele frequency- A:0.08NA 124
    rs1450291521,2
    --37406399(+) TGCAGA/TTCTGC 3 -- int1 ds50010--------
    rs733704311,2
    C,F--37406543(+) AGCACG/AATCCT 3 -- int1 ds50012Minor allele frequency- A:0.04WA 120
    rs1813185621,2
    --37406647(+) GCTCAC/TTTTTT 3 -- int1 ds50010--------
    rs7434221,2
    C,F,A--37406678(+) GATTGG/TGGGGC 3 -- int1 ds50018Minor allele frequency- T:0.34NA WA CSA EA 368
    rs8786061,2
    C,F,A--37406692(+) GGGACG/ACATTA 3 -- int1 ds50018Minor allele frequency- A:0.27NA WA CSA EA 372
    rs1388703321,2
    --37406753(+) GCCTCC/TCCTGA 3 -- int1 ds50010--------
    rs1143849201,2
    C,F--37406794(+) CCACTG/ACGCAG 3 -- int1 ds50011Minor allele frequency- A:0.02WA 118
    rs7623641,2
    C,F,O,A,H--37406849(+) TCTGCA/GAAGTT 3 -- ut31 nc-transcript-variantese335Minor allele frequency- N:0.00NA EA MN NS WA CSA 3425

    HapMap Linkage Disequilibrium report for SETD4 (37406839 - 37451687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SETD4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1004462CNV Deletion20482838
    esv2723388CNV Deletion23290073
    esv2665899CNV Deletion23128226
    esv2723389CNV Deletion23290073
    nsv3504CNV Insertion18451855
    nsv459247CNV Loss19166990
    nsv470899CNV Loss18288195
    nsv913730CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SETD4
    DNA2.0 Custom Variant and Variant Library Synthesis for SETD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SETD4:    About MalaCards
    down syndrome    


    SETD4 for disorders           About GeneDecksing


    Export disorders for SETD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SETD4 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with SETD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    4. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PubMed id 11707072)1, 2 Reymond A....Antonarakis S.E. (2001)
    5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54093 HGNC: 1258 AceView: C21orf18 Ensembl:ENSG00000185917 euGenes: HUgn54093
    ECgene: SETD4 H-InvDB: SETD4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SETD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SETD4 gene:
    Search GeneIP for patents involving SETD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SETD4  
     OriGene qPCR primer pairs and template standards for SETD4   OriGene Protein Over-expression Lysate for SETD4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SETD4  
     OriGene qSTAR qPCR primer pairs in human, mouse for SETD4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SETD4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SETD4   OriGene Custom Protein Services for SETD4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SETD4
     QIAGEN SeqTarget long-range PCR primers for resequencing SETD4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SETD4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SETD4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SETD4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SETD4
     GenScript Custom Purified and Recombinant Proteins Services for SETD4 GenScript cDNA clones with any tag delivered in your preferred vector for SETD4
     GenScript Custom Assay Services for SETD4 GenScript Custom Superior Antibodies Services for SETD4
     GenScript Custom overexpressing Cell Line Services for SETD4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SETD4 promoter
     Search Chromatin IP Primers for SETD4
     RT2 qPCR Primer Assay in human, mouse, rat SETD4
     Search GNC Networks for SETD4
     SABiosciences PCR Arrays including human, mouse, rat SETD4
     Search Tocris compounds for SETD4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SETD4 antibodies
     SETD4 proteins
     SETD4 lysates
     Antibodies for SETD4
     See all of Abcam's Antibodies, Kits and Proteins for SETD4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SETD4
     Antibodies for SETD4
     ELISAs for SETD4
     CLIAs for SETD4
     Search LifeMap BioReagents cell lines for SETD4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD4
     SwitchGear 3'UTR luciferase reporter plasmids for SETD4
     SwitchGear Promoter luciferase reporter plasmids for SETD4
     Search ThermoFisher Antibodies for SETD4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SETD4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SETD4
    Customized:
     lentivirus for stable overexpression of SETD4
     lentivirus expression plasmids for stable overexpression of SETD4
     adenovirus for overexpression of SETD4
     LSBio Antibodies in human, mouse, rat for SETD4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SETD4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4