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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SETD3 Gene

protein-coding   GIFtS: 44
GCID: GC14M099864

SET Domain Containing 3

(Previous name: chromosome 14 open reading frame 154)
(Previous symbol: C14orf154)
  Search for SETD3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SET Domain Containing 31 2
C14orf1541 2 3
SET Domain-Containing Protein 32 3
Chromosome 14 Open Reading Frame 1541
Histone-Lysine N-Methyltransferase Setd32
EC 2.1.1.433

External Ids:    HGNC: 204931   Entrez Gene: 841932   Ensembl: ENSG000001835767   UniProtKB: Q86TU73   

Export aliases for SETD3 gene to outside databases

Previous GC identifers: GC14M098934 GC14M080047


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SETD3 Gene: 
SETD3 (SET domain containing 3) is a protein-coding gene. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and transcription coactivator activity. An important paralog of this gene is SETD4.

UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7
Function: Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation
represents a specific tag for epigenetic transcriptional activation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SETD3 gene promoter:
         ER-alpha   MAZR   AML1a   p53   POU6F1 (c2)   Meis-1b   FAC1   FOXO4   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSETD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SETD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SETD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

SETD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETD3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M099864:  view genomic region     (about GC identifiers)

Start:
99,864,083 bp from pter      End:
99,947,226 bp from pter
Size:
83,144 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase setd3  
Size: 594 amino acids; 67257 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAB15525.1; Type=Frameshift; Positions=486, 495;
1 PDB 3D structure from and Proteopedia for SETD3:
3SMT (3D)    
Secondary accessions: A0PJU3 A5PLP0 B4DZE8 Q0VAQ2 Q659C0 Q86TU8 Q96GY9 Q9H5U5
Alternative splicing: 3 isoforms:  Q86TU7-1   Q86TU7-2   Q86TU7-3   

Explore the universe of human proteins at neXtProt for SETD3: NX_Q86TU7

Explore proteomics data for SETD3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86TU7

  • SETD3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SETD3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_115609.2  NP_954574.1  

    ENSEMBL proteins: 
     ENSP00000327436   ENSP00000396870   ENSP00000398966   ENSP00000327910   ENSP00000408602  
     ENSP00000350174  

    Human Recombinant Protein Products for SETD3: 
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    OriGene MassSpec for SETD3 
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    Novus Biologicals SETD3 Protein
    Novus Biologicals SETD3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SETD3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--

    SETD3 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for SETD3 

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    Cloud-Clone Corp. ELISAs for SETD3 
    Cloud-Clone Corp. CLIAs for SETD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001214 SET_dom
     IPR015353 Rubisco_LSMT_subst-bd
     IPR025785 Hist-Lys_N-MeTrfase_SETD3

    Graphical View of Domain Structure for InterPro Entry Q86TU7

    ProtoNet protein and cluster: Q86TU7

    1 Blocks protein domain: IPB001214 Nuclear protein SET

    UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. SETD3 subfamily
    Similarity: Contains 1 SET domain


    SETD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SETD3_HUMAN, Q86TU7
    Function: Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation
    represents a specific tag for epigenetic transcriptional activation (By similarity)
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Number (IUBMB): EC 2.1.1.431

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001102RNA polymerase II activating transcription factor binding IEA--
    GO:0003713transcription coactivator activity ISS--
    GO:0005515protein binding ----
    GO:0042800histone methyltransferase activity (H3-K4 specific) IEA--
    GO:0046975histone methyltransferase activity (H3-K36 specific) ISS--
         
    SETD3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SETD3:
     G0/1 arrest  Increased G1 DNA content 

         1 MGI phenotypic allele for Setd3 (no phenotypes)

    SETD3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SETD3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SETD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SETD3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SETD3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SETD3
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate SETD3 (see all 21):
    hsa-miR-19b-2* hsa-miR-15a hsa-miR-216b hsa-miR-340 hsa-miR-877* hsa-miR-424 hsa-miR-7-1* hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidSETD3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SETD3 (NM_032233)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD3
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                         Customized lentivirus expression plasmids for stable overexpression of SETD3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SETD3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for SETD3 (Q86TU73 ENSP000003274364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR5A2O004823I2D: score=5 
    RPL27P613533I2D: score=5 
    MYOD1ENSP000002500034STRING: ENSP00000250003
    KNCNENSP000003796074STRING: ENSP00000379607
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0010452histone H3-K36 methylation ISS--
    GO:0018023peptidyl-lysine trimethylation ISS--
    GO:0018026peptidyl-lysine monomethylation ISS--
    GO:0018027peptidyl-lysine dimethylation ISS--

    SETD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SETD3

    Search CenterWatch for drugs/clinical trials and news about SETD3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SETD3 gene (2 alternative transcripts): 
    NM_032233.2  NM_199123.1  

    Unigene Cluster for SETD3:

    SET domain containing 3
    Hs.510407  [show with all ESTs]
    Unigene Representative Sequence: AK302882
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331768(uc001ygc.3) ENST00000446066 ENST00000489770 ENST00000453764
    ENST00000329331(uc001ygd.3 uc021sbn.1) ENST00000436070(uc001ygf.3)
    ENST00000357563 ENST00000453938
    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate SETD3 (see all 21):
    hsa-miR-19b-2* hsa-miR-15a hsa-miR-216b hsa-miR-340 hsa-miR-877* hsa-miR-424 hsa-miR-7-1* hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidSETD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SETD3
    Clone
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    OriGene clones in human, mouse for SETD3 (see all 13)
    OriGene ORF clones in mouse, rat for SETD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SETD3 (NM_032233)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD3
    Sirion Biotech Customized lentivirus for stable overexpression of SETD3 
                         Customized lentivirus expression plasmids for stable overexpression of SETD3 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SETD3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SETD3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SETD3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SETD3

    Additional mRNA sequence: 

    AK026680.1 AK302882.1 AL359581.2 BC009054.1 BC037395.1 BC066931.1 BC120967.1 BC120968.2 
    BC127624.1 BC127625.1 BC127644.1 BC142995.1 BC148251.1 BX161441.1 BX161471.1 

    18 DOTS entries:

    DT.100848358  DT.409744  DT.98131677  DT.102827646  DT.456373  DT.91771725  DT.100841526  DT.95079238 
    DT.100044474  DT.100678063  DT.91771740  DT.97846885  DT.100658031  DT.100867385  DT.120788218  DT.120788279 
    DT.95079235  DT.95079228 

    24/314 AceView cDNA sequences (see all 314):

    AA300089 BF476562 AI272032 BF475988 AI243225 AI769265 BF436914 BG236066 
    CB217137 AA228022 AV652746 AW439607 BE645783 BX161471 BU754571 BM849756 
    AI024925 AA032045 BM910387 CB156875 BU628428 AI674466 AI262224 BE779641 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SETD3 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c
    SP1:                                            -     -           -                 -                       -                           
    SP2:                                            -     -           -                                                                     
    SP3:                          -                 -     -           -                                                                     
    SP4:                                            -                                                                                       
    SP5:                                            -     -           -                                                                     


    ECgene alternative splicing isoforms for SETD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SETD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SETD3 Expression
    About this image


    See SETD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SETD3

    SOURCE GeneReport for Unigene cluster: Hs.510407
        SABiosciences Expression via Pathway-Focused PCR Array including SETD3: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SETD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SETD3 gene from 10/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Setd31 , 5 SET domain containing 31, 5 87.44(n)1
    92.57(a)1
      12 (59.23 cM)5
    526901  NM_028262.31  NP_082538.21 
     1081064315 
    chicken
    (Gallus gallus)
    Aves LOC1008593371 histone-lysine N-methyltransferase setd3-like 79.73(n)
    85.64(a)
      100859337  XM_003641411.1  XP_003641459.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    SETD36
    Uncharacterized protein
    83(a)
    80(a)
    possible ortholog
    1 ↔ 1
    GL343270.1(1848650-1863404)
    1(10231662-10240368)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.157112 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_115609.1 (H.sapiens) hypothetical protein FLJ23027 [Homo sapiens] less 80.87(n)    BJ030987.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb01d122 wufb01d12 75.34(n)   337193  BC055261.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG327321 CG32732 45.73(n)
    36.75(a)
      31638  NM_167100.2  NP_727144.1 
    worm
    (Caenorhabditis elegans)
    Secernentea set-271 Protein SET-27 45.17(n)
    33.41(a)
      190607  NM_065203.2  NP_497604.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RKM46
    Ribosomal lysine methyltransferase specific for mo...
    15(a)
    1 → many
    IV(969990-971474)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G140301 [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase less 43.04(n)
    29.92(a)
      837964  NM_101269.2  NP_172856.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g04116501 hypothetical protein 44.27(n)
    34.95(a)
      9266797  NM_001188905.1  NP_001175834.1 


    ENSEMBL Gene Tree for SETD3 (if available)
    TreeFam Gene Tree for SETD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SETD3 gene
    SETD42  

    SETD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1650 SNPs in SETD3 are shown (see all 1650)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs575082811,2
    C--80856138(+) CTGAT-/GTAGCCC 1 -- int12Minor allele frequency- GT:0.25NA CSA 4
    rs1850885001,2
    --99863635(+) TCCCAC/GAGCAT 1 -- ds50010--------
    rs1435020211,2
    C--99863680(+) AAACAC/GTTGGG 1 -- ds50010--------
    rs803546301,2
    C,F--99863740(+) CAATGT/CGAAAA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1896010111,2
    --99863777(+) GTAAAA/CCTGAA 1 -- ds50010--------
    rs1833275011,2
    --99863798(+) AGAAGA/GAGACA 1 -- ds50010--------
    rs779334471,2
    C,F--99863869(+) CTCCTT/CTTCTT 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1887058711,2
    --99863942(+) CCCACA/GGCTAT 1 -- ds50010--------
    rs1384509721,2
    --99863968(+) AGGTTA/CGCACA 1 -- ds50010--------
    rs1919824871,2
    --99863972(+) TAGCAC/TAGCCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SETD3 (99864083 - 99947226 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SETD3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv902217CNV Loss21882294
    nsv832872CNV Loss17160897
    nsv832871CNV Gain17160897
    esv997017OTHER Inversion20482838

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SETD3 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SETD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
    5. Histone methyltransferase SETD3 regulates muscle diffe rentiation. (PubMed id 21832073)1 Eom G.H....Seo S.B. (2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84193 HGNC: 20493 AceView: C14orf154 Ensembl:ENSG00000183576 euGenes: HUgn84193
    ECgene: SETD3 H-InvDB: SETD3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SETD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SETD3 gene:
    Search GeneIP for patents involving SETD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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