Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SETD3 Gene

protein-coding   GIFtS: 43
GCID: GC14M099864

SET domain containing 3

(Previous name: chromosome 14 open reading frame 154 )
(Previous symbol: C14orf154)
 Explore 1 disease affiliated with
SETD3 via our new
 Human Malady Compendium 
Biological research products
for SETD3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
SET Domain Containing 31 2     Chromosome 14 Open Reading Frame 1541
C14orf1541 2 3     Histone-Lysine N-Methyltransferase Setd32
SET Domain-Containing Protein 32 3     EC 2.1.1.433
FLJ230271     

External Ids:    HGNC: 204931   Entrez Gene: 841932   Ensembl: ENSG000001835767   UniProtKB: Q86TU73   

Export aliases for SETD3 gene to outside databases

Previous GC identifers: GC14M098934 GC14M080047


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7
Function: Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation
represents a specific tag for epigenetic transcriptional activation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SETD3 gene promoter:
         ER-alpha   MAZR   AML1a   p53   POU6F1 (c2)   Meis-1b   FAC1   FOXO4   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSETD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SETD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SETD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

SETD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETD3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M099864:  view genomic region     (about GC identifiers)

Start:
99,864,083 bp from pter      End:
99,947,226 bp from pter
Size:
83,144 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase setd3  
Size: 594 amino acids; 67257 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAB15525.1; Type=Frameshift; Positions=486, 495;
1 PDB 3D structure from and Proteopedia for SETD3:
3SMT (3D)    
Secondary accessions: A0PJU3 A5PLP0 B4DZE8 Q0VAQ2 Q659C0 Q86TU8 Q96GY9 Q9H5U5
Alternative splicing: 3 isoforms:  Q86TU7-1   Q86TU7-2   Q86TU7-3   

Explore the universe of human proteins at neXtProt for SETD3: NX_Q86TU7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86TU7

  • SETD3 Protein expression data from MOPED and PaxDb:    About this image 
    SETD3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_115609.2  NP_954574.1  

    ENSEMBL proteins: 
     ENSP00000327436   ENSP00000396870   ENSP00000398966   ENSP00000327910   ENSP00000408602  
     ENSP00000350174  

    Human Recombinant Protein Products for SETD3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SETD3
    OriGene Protein Over-expression Lysate (see all 2): SETD3
    OriGene Custom Protein Services for SETD3 
    GenScript Custom Purified and Recombinant Proteins Services for SETD3
    Novus Biologicals SETD3 Protein
    Novus Biologicals SETD3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SETD3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus ----

    SETD3 for ontologies           About GeneDecksing



    SETD3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SETD3 
    GenScript Custom Superior Antibodies Services for SETD3
    Novus Biologicals SETD3 Antibodies
    Abcam antibodies for SETD3 
    Uscn Antibodies for SETD3
    Search ThermoFisher Antibodies for SETD3

    Assay Products for SETD3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SETD3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SETD3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SETD3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001214 SET_dom
     IPR015353 Rubisco_LSMT_subst-bd
     IPR025785 Hist-Lys_N-MeTrfase_SETD3

    Graphical View of Domain Structure for InterPro Entry Q86TU7

    ProtoNet protein and cluster: Q86TU7

    1 Blocks protein family: IPB001214 Nuclear protein SET

    UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7
    Similarity: Belongs to the SETD3 family
    Similarity: Contains 1 SET domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SETD3_HUMAN, Q86TU7
    Function: Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation
    represents a specific tag for epigenetic transcriptional activation (By similarity)
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Number (IUBMB): EC 2.1.1.431

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001102RNA polymerase II activating transcription factor binding IEA--
    GO:0003713transcription coactivator activity ISS--
    GO:0042800histone methyltransferase activity (H3-K4 specific) IEA--
    GO:0046975histone methyltransferase activity (H3-K36 specific) ISS--
         
    SETD3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SETD3:
     G0/1 arrest  Increased G1 DNA content 

         1 MGI phenotypic allele for Setd3 (no phenotypes)

    SETD3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SETD3 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): SETD3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SETD3
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate SETD3 (see all 21):
    hsa-miR-19b-2* hsa-miR-15a hsa-miR-216b hsa-miR-340 hsa-miR-877* hsa-miR-424 hsa-miR-7-1* hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidSETD3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SETD3 (see all 4)
    OriGene shRNA RFP: SETD3
    OriGene siRNA: SETD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SETD3
    Sirion Biotech Custom design and validation of potent shRNA sequences against SETD3 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SETD3
    Sirion Biotech Customized adenovirus for overexpression of SETD3 
    Sirion Biotech Customized adenovirus for potent knockdown of SETD3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SETD3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SETD3 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SETD3 (NM_032233)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SETD3
    Search LifeMap BioReagents cell lines for SETD3
    Sirion Biotech Customized stable knockdown cell line services for SETD3 
    Sirion Biotech Customized inducible knockdown cell line services for SETD3
    Sirion Biotech Customized stable overexpressing cell line services for SETD3
    Sirion Biotech Customized inducible overexpressing cell line services for SETD3

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SETD3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for SETD3 (Q86TU73 ENSP000003274364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR5A2O004823I2D: score=5 
    RPL27P613533I2D: score=5 
    MYOD1ENSP000002500034STRING: ENSP00000250003
    KNCNENSP000003796074STRING: ENSP00000379607
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0010452histone H3-K36 methylation ISS--
    GO:0018023peptidyl-lysine trimethylation ISS--
    GO:0018026peptidyl-lysine monomethylation ISS--
    GO:0018027peptidyl-lysine dimethylation ISS--

    SETD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SETD3
    Search CenterWatch for drugs/clinical trials and news about SETD3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SETD3 gene (2 alternative transcripts): 
    NM_032233.2  NM_199123.1  

    Unigene Cluster for SETD3:

    SET domain containing 3
    Hs.510407  [show with all ESTs]
    Unigene Representative Sequence: AK302882
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331768(uc001ygc.3) ENST00000446066 ENST00000489770 ENST00000453764
    ENST00000329331(uc001ygd.3 uc021sbn.1) ENST00000436070(uc001ygf.3)
    ENST00000357563 ENST00000453938

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): SETD3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SETD3
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate SETD3 (see all 21):
    hsa-miR-19b-2* hsa-miR-15a hsa-miR-216b hsa-miR-340 hsa-miR-877* hsa-miR-424 hsa-miR-7-1* hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidSETD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SETD3 (see all 4)
    OriGene shRNA RFP: SETD3
    OriGene siRNA: SETD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SETD3
    Sirion Biotech Custom design and validation of potent shRNA sequences against SETD3 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SETD3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SETD3 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SETD3 (NM_032233)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD3 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SETD3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SETD3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SETD3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SETD3

    Additional cDNA sequence: 

    AK026680.1 AK302882.1 AL359581.2 BC009054.1 BC037395.1 BC066931.1 BC120967.1 BC120968.2 
    BC127624.1 BC127625.1 BC127644.1 BC142995.1 BC148251.1 BX161441.1 BX161471.1 

    18 DOTS entries:

    DT.100848358  DT.409744  DT.98131677  DT.102827646  DT.456373  DT.91771725  DT.100841526  DT.95079238 
    DT.100044474  DT.100678063  DT.91771740  DT.97846885  DT.100658031  DT.100867385  DT.120788218  DT.120788279 
    DT.95079235  DT.95079228 

    24/314 AceView cDNA sequences (see all 314):

    AA032045 BP340301 AI000350 CB988965 BU683176 BF436914 CA423159 BG170266 
    BC066931 AI674466 BQ187137 AI262224 AW003651 BF476562 AI628785 N59017 
    AA233077 AV652746 AI500313 BP349478 BX360516 BQ896693 W58691 AI131092 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SETD3 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c
    SP1:                                            -     -           -                 -                       -                           
    SP2:                                            -     -           -                                                                     
    SP3:                          -                 -     -           -                                                                     
    SP4:                                            -                                                                                       
    SP5:                                            -     -           -                                                                     


    ECgene alternative splicing isoforms for SETD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SETD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    SETD3 Expression
    About this image
    See SETD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SETD3

    SOURCE GeneReport for Unigene cluster: Hs.510407
        SABiosciences Expression via Pathway-Focused PCR Array including SETD3: 

              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SETD3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SETD3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SETD3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SETD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SETD3 gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Setd31 , 5 SET domain containing 31, 5 87.44(n)1
    92.57(a)1
      12 (59.23 cM)5
    526901  NM_028262.31  NP_082538.21 
     1081064315 
    chicken
    (Gallus gallus)
    Aves LOC1008593371 histone-lysine N-methyltransferase setd3-like 79.73(n)
    85.64(a)
      100859337  XM_003641411.1  XP_003641459.1 
    lizard
    (Anolis carolinensis)
    Reptilia SETD36
    SETD36
    --
    86(a)
    80(a)
    possible ortholog
    1 ↔ 1
    GL343270.1(1848657-1853580)
    1(10231662-10240360)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.157112 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_115609.1 (H.sapiens) hypothetical protein FLJ23027 [Homo sapiens] less 80.87(n)    BJ030987.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb01d122 wufb01d12 75.34(n)   337193  BC055261.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG327321 CG32732 45.73(n)
    36.75(a)
      31638  NM_167100.2  NP_727144.1 
    worm
    (Caenorhabditis elegans)
    Secernentea set-271 Protein SET-27 45.17(n)
    33.41(a)
      190607  NM_065203.2  NP_497604.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G140301 [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase less 43.04(n)
    29.92(a)
      837964  NM_101269.2  NP_172856.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g04116501 hypothetical protein 44.27(n)
    34.95(a)
      9266797  NM_001188905.1  NP_001175834.1 


    ENSEMBL Gene Tree for SETD3 (if available)
    TreeFam Gene Tree for SETD3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SETD3 gene
    SETD62  

    SETD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1365 NCBI SNPs in SETD3 are shown (see all 1365    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs32156791,2
    C--80054333(-) TTATT-/GTTAACAC 1 -- int10--------
    rs1850885001,2
    --99863635(+) TCCCAC/GAGCAT 1 -- ds50010--------
    rs1435020211,2
    --99863680(+) AAACAC/GTTGGG 1 -- ds50010--------
    rs803546301,2
    F--99863740(+) CAATGT/CGAAAA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1896010111,2
    --99863777(+) GTAAAA/CCTGAA 1 -- ds50010--------
    rs1833275011,2
    --99863798(+) AGAAGA/GAGACA 1 -- ds50010--------
    rs779334471,2
    C,F--99863869(+) CTCCTT/CTTCTT 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1887058711,2
    --99863942(+) CCCACA/GGCTAT 1 -- ds50010--------
    rs1384509721,2
    --99863968(+) AGGTTA/CGCACA 1 -- ds50010--------
    rs1919824871,2
    --99863972(+) TAGCAC/TAGCCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SETD3 (99864083 - 99947226 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SETD3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SETD3
    DNA2.0 Custom Variant and Variant Library Synthesis for SETD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SETD3 for disorders           About GeneDecksing

    1 disease for SETD3:    About MalaCards
    homocysteine


    Export disorders for SETD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SETD3 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SETD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
    5. Histone methyltransferase SETD3 regulates muscle diffe rentiation. (PubMed id 21832073)1 Eom G.H....Seo S.B. (2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84193 HGNC: 20493 AceView: C14orf154 Ensembl:ENSG00000183576 euGenes: HUgn84193
    ECgene: SETD3 H-InvDB: SETD3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SETD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SETD3 gene:
    Search GeneIP for patents involving SETD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SETD3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SETD3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SETD3  
     OriGene Protein Over-expression Lysate for SETD3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SETD3   OriGene 3'-UTR Clone for SETD3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SETD3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SETD3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SETD3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SETD3   OriGene Custom Protein Services for SETD3  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SETD3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SETD3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SETD3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SETD3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SETD3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SETD3
     GenScript Custom Purified and Recombinant Proteins Services for SETD3 GenScript cDNA clones with any tag delivered in your preferred vector for SETD3
     GenScript Custom Assay Services for SETD3 GenScript Custom Superior Antibodies Services for SETD3
     GenScript Custom overexpressing Cell Line Services for SETD3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SETD3 promoter
     Search Chromatin IP Primers for SETD3
     RT2 qPCR Primer Assay in human, mouse, rat SETD3
     Search GNC Networks for SETD3
     SABiosciences PCR Arrays including human, mouse, rat SETD3
     Search Tocris compounds for SETD3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SETD3 antibodies
     SETD3 proteins
     SETD3 lysates
     Antibodies for SETD3
     See all of Abcam's Antibodies, Kits and Proteins for SETD3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SETD3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SETD3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD3
     SwitchGear 3'UTR luciferase reporter plasmids for SETD3
     SwitchGear Promoter luciferase reporter plasmids for SETD3
     Search ThermoFisher Antibodies for SETD3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD3
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SETD3
    Sirion Biotech Customized:
     stable knockdown cell line services for SETD3
     inducible knockdown cell line services for SETD3
     design and validation of potent shRNA sequences against SETD3
     adenovirus for potent knockdown of SETD3
     adenovirus for overexpression of SETD3
     stable overexpressing cell line services for SETD3
     inducible overexpressing cell line services for SETD3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SETD3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4