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Aliases for SETD3 Gene

Aliases for SETD3 Gene

  • SET Domain Containing 3 2 3
  • SET Domain-Containing Protein 3 3 4
  • C14orf154 3 4
  • Histone-Lysine N-Methyltransferase Setd3 3
  • Chromosome 14 Open Reading Frame 154 2
  • EC 4

External Ids for SETD3 Gene

Previous HGNC Symbols for SETD3 Gene

  • C14orf154

Previous GeneCards Identifiers for SETD3 Gene

  • GC14M098934
  • GC14M099864
  • GC14M080047

Summaries for SETD3 Gene

GeneCards Summary for SETD3 Gene

SETD3 (SET Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity and histone methyltransferase activity (H3-K4 specific). An important paralog of this gene is SETD4.

UniProtKB/Swiss-Prot for SETD3 Gene

  • Histone methyltransferase that methylates Lys-4 and Lys-36 of histone H3 (H3K4me and H3K36me). Acts as a transcriptional activator. Plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SETD3 Gene

Genomics for SETD3 Gene

Regulatory Elements for SETD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SETD3 Gene

99,397,746 bp from pter
99,480,891 bp from pter
83,146 bases
Minus strand

Genomic View for SETD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SETD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SETD3 Gene

Proteins for SETD3 Gene

  • Protein details for SETD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histone-lysine N-methyltransferase setd3
    Protein Accession:
    Secondary Accessions:
    • A0PJU3
    • A5PLP0
    • B4DZE8
    • Q0VAQ2
    • Q659C0
    • Q86TU8
    • Q96GY9
    • Q9H5U5

    Protein attributes for SETD3 Gene

    594 amino acids
    Molecular mass:
    67257 Da
    Quaternary structure:
    • Interacts with MYOD1.
    • Sequence=BAB15525.1; Type=Frameshift; Positions=486, 495; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SETD3 Gene

    Alternative splice isoforms for SETD3 Gene


neXtProt entry for SETD3 Gene

Proteomics data for SETD3 Gene at MOPED

Post-translational modifications for SETD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SETD3 Gene

No data available for DME Specific Peptides for SETD3 Gene

Domains for SETD3 Gene

Protein Domains for SETD3 Gene

Suggested Antigen Peptide Sequences for SETD3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q86TU7
  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD3 subfamily.
genes like me logo Genes that share domains with SETD3: view

No data available for Gene Families for SETD3 Gene

Function for SETD3 Gene

Molecular function for SETD3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
UniProtKB/Swiss-Prot Function: Histone methyltransferase that methylates Lys-4 and Lys-36 of histone H3 (H3K4me and H3K36me). Acts as a transcriptional activator. Plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1.

Enzyme Numbers (IUBMB) for SETD3 Gene

Gene Ontology (GO) - Molecular Function for SETD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding IEA --
GO:0003713 transcription coactivator activity ISS --
GO:0005515 protein binding --
GO:0042800 histone methyltransferase activity (H3-K4 specific) IEA --
GO:0046975 histone methyltransferase activity (H3-K36 specific) ISS --
genes like me logo Genes that share ontologies with SETD3: view

Phenotypes for SETD3 Gene

GenomeRNAi human phenotypes for SETD3:
genes like me logo Genes that share phenotypes with SETD3: view

Animal Model Products

CRISPR Products

miRNA for SETD3 Gene

miRTarBase miRNAs that target SETD3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SETD3 Gene

Localization for SETD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SETD3 Gene

Subcellular locations from

Jensen Localization Image for SETD3 Gene COMPARTMENTS Subcellular localization image for SETD3 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SETD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
genes like me logo Genes that share ontologies with SETD3: view

Pathways for SETD3 Gene

SuperPathways for SETD3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Modification Enzymes in human,mouse,rat

Gene Ontology (GO) - Biological Process for SETD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0010452 histone H3-K36 methylation ISS --
GO:0018022 peptidyl-lysine methylation --
GO:0018023 peptidyl-lysine trimethylation ISS --
GO:0018026 peptidyl-lysine monomethylation ISS --
genes like me logo Genes that share ontologies with SETD3: view

No data available for Pathways by source for SETD3 Gene

Transcripts for SETD3 Gene

Unigene Clusters for SETD3 Gene

SET domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SETD3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SETD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SETD3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - - -
SP7: - - - - -

Relevant External Links for SETD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SETD3 Gene

mRNA expression in normal human tissues for SETD3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SETD3 Gene

SOURCE GeneReport for Unigene cluster for SETD3 Gene Hs.510407

genes like me logo Genes that share expressions with SETD3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SETD3 Gene

Orthologs for SETD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SETD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SETD3 35
  • 99.49 (n)
  • 99.83 (a)
SETD3 36
  • 100 (a)
(Bos Taurus)
Mammalia SETD3 35
  • 86.58 (n)
  • 92.05 (a)
SETD3 36
  • 92 (a)
(Canis familiaris)
Mammalia SETD3 35
  • 86.6 (n)
  • 90.8 (a)
SETD3 36
  • 89 (a)
(Mus musculus)
Mammalia Setd3 35
  • 87.44 (n)
  • 92.57 (a)
Setd3 16
Setd3 36
  • 92 (a)
(Monodelphis domestica)
Mammalia SETD3 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
-- 36
  • 85 (a)
-- 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Setd3 35
  • 87.77 (n)
  • 92.09 (a)
(Gallus gallus)
Aves -- 36
  • 81 (a)
-- 36
  • 88 (a)
LOC100859337 35
  • 79.73 (n)
  • 85.64 (a)
SETD3 36
  • 78 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
-- 36
  • 83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15711 35
tropical clawed frog
(Silurana tropicalis)
Amphibia setd3 35
  • 74.48 (n)
  • 78.97 (a)
Str.4852 35
(Danio rerio)
Actinopterygii setd3 35
  • 69.03 (n)
  • 74.11 (a)
setd3 36
  • 71 (a)
wufb01d12 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002018 35
  • 45.15 (n)
  • 35.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32732 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea set-27 35
  • 45.37 (n)
  • 32.92 (a)
set-27 36
  • 23 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08733 35
  • 41.06 (n)
  • 27.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for SETD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SETD3 Gene

Gene Tree for SETD3 (if available)
Gene Tree for SETD3 (if available)

Paralogs for SETD3 Gene

Paralogs for SETD3 Gene

genes like me logo Genes that share paralogs with SETD3: view

Variants for SETD3 Gene

Sequence variations from dbSNP and Humsavar for SETD3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2943 -- 99,409,879(-) ATGAC(C/T)GGTAA intron-variant, utr-variant-3-prime
rs8402 -- 99,397,860(+) CACCA(A/C)CACGT utr-variant-3-prime
rs941552 -- 99,471,888(-) AGGTC(A/G)TGGGC intron-variant
rs941553 -- 99,457,883(-) ATTGA(C/T)AGTTA intron-variant
rs941554 -- 99,457,699(-) TTGAA(C/T)AGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SETD3 Gene

Variant ID Type Subtype PubMed ID
nsv832871 CNV Gain 17160897
nsv832872 CNV Loss 17160897
nsv902217 CNV Loss 21882294
esv997017 OTHER Inversion 20482838

Relevant External Links for SETD3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SETD3 Gene

Disorders for SETD3 Gene

No disorders were found for SETD3 Gene.

No data available for UniProtKB/Swiss-Prot for SETD3 Gene

Publications for SETD3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PMID: 16094384) Tao W.A. … Aebersold R. (Nat. Methods 2005) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for SETD3 Gene

Sources for SETD3 Gene

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