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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SETD3 Gene

protein-coding GIFtS: 44
GCID: GC14M099864

SET Domain Containing 3

(Previous name: chromosome 14 open reading frame 154)
(Previous symbol: C14orf154)

Search for SETD3
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
SET Domain Containing 3¹ ²
C14orf154¹ ² ³
SET Domain-Containing Protein 3² ³
Chromosome 14 Open Reading Frame 154¹
Histone-Lysine N-Methyltransferase Setd3²
EC 2.1.1.43³

External Ids:	HGNC: 20493¹	Entrez Gene: 84193²	Ensembl: ENSG00000183576⁷	UniProtKB: Q86TU7³

Export aliases for SETD3 gene to outside databases

Previous GC identifers: GC14M098934 GC14M080047

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SETD3 Gene:

SETD3 (SET domain containing 3) is a protein-coding gene. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and transcription coactivator activity. An important paralog of this gene is SETD4.

UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7

Function: Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation

represents a specific tag for epigenetic transcriptional activation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NT_026437.12 NC_018925.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SETD3 gene promoter:
ER-alpha MAZR AML1a p53 POU6F1 (c2) Meis-1b FAC1 FOXO4 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SETD3 promoter sequence

Search SABiosciences Chromatin IP Primers for SETD3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SETD3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.2

SETD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETD3 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M099864: view genomic region (about GC identifiers)

Start:	99,864,083 bp from pter	End:	99,947,226 bp from pter
Size:	83,144 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7 (See protein sequence)

Recommended Name: Histone-lysine N-methyltransferase setd3

Size: 594 amino acids; 67257 Da

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=BAB15525.1; Type=Frameshift; Positions=486, 495;

1 PDB 3D structure from and Proteopedia for SETD3:

3SMT (3D)

Secondary accessions: A0PJU3 A5PLP0 B4DZE8 Q0VAQ2 Q659C0 Q86TU8 Q96GY9 Q9H5U5

Alternative splicing: 3 isoforms: Q86TU7-1 Q86TU7-2 Q86TU7-3

Explore the universe of human proteins at neXtProt for SETD3: NX_Q86TU7

Explore proteomics data for SETD3 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q86TU7

SETD3 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_115609.2 NP_954574.1

ENSEMBL proteins:

ENSP00000327436 ENSP00000396870 ENSP00000398966 ENSP00000327910 ENSP00000408602

ENSP00000350174

Human Recombinant Protein Products for SETD3:

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	OriGene Purified Protein for SETD3 OriGene Protein Over-expression Lysate for SETD3 OriGene MassSpec for SETD3 OriGene Custom Protein Services for SETD3
	GenScript Custom Purified and Recombinant Proteins Services for SETD3
	Novus Biologicals SETD3 Protein Novus Biologicals SETD3 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for SETD3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	IEA	--

SETD3 for ontologies About GeneDecksing

SETD3 Antibody Products:

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	GenScript Custom Superior Antibodies Services for SETD3
	Novus Biologicals SETD3 Antibodies
	Abcam antibodies for SETD3
	Cloud-Clone Corp. Antibodies for SETD3
	Search ThermoFisher Antibodies for SETD3
	LSBio Antibodies in human, mouse, rat for SETD3

Assay Products for SETD3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SETD3
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	GenScript Custom Assay Services for SETD3
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	Cloud-Clone Corp. ELISAs for SETD3 Cloud-Clone Corp. CLIAs for SETD3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro protein domains:

IPR001214 SET_dom

IPR015353 Rubisco_LSMT_subst-bd

IPR025785 Hist-Lys_N-MeTrfase_SETD3

Graphical View of Domain Structure for InterPro Entry Q86TU7

ProtoNet protein and cluster: Q86TU7

1 Blocks protein domain: IPB001214 Nuclear protein SET

UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7

Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine

methyltransferase family. SETD3 subfamily

Similarity: Contains 1 SET domain

SETD3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SETD3_HUMAN, Q86TU7

Function: Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation

represents a specific tag for epigenetic transcriptional activation (By similarity)

Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +

N(6)-methyl-L-lysine-[histone]

Enzyme Number (IUBMB): EC 2.1.1.43¹

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001102	RNA polymerase II activating transcription factor binding	IEA	--
GO:0003713	transcription coactivator activity	ISS	--
GO:0005515	protein binding	--	--
GO:0042800	histone methyltransferase activity (H3-K4 specific)	IEA	--
GO:0046975	histone methyltransferase activity (H3-K36 specific)	ISS	--

SETD3 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for SETD3:

G0/1 arrest

Increased G1 DNA content

1 MGI phenotypic allele

for Setd3 (no phenotypes)

SETD3 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for SETD3

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SETD3

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SETD3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SETD3

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SETD3
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate SETD3 (see all 21):
		hsa-miR-19b-2* hsa-miR-15a hsa-miR-216b hsa-miR-340 hsa-miR-877* hsa-miR-424 hsa-miR-7-1* hsa-miR-195

		SwitchGear 3'UTR luciferase reporter plasmid: SETD3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SETD3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SETD3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SETD3
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): SETD3 (NM_032233)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SETD3
		Search LifeMap BioReagents cell lines for SETD3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SETD3

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5 Interacting proteins for SETD3 (Q86TU7³ ENSP00000327436⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NR5A2	O00482³	I2D: score=5
RPL27	P61353³	I2D: score=5
MYOD1	ENSP00000250003⁴	STRING: ENSP00000250003
KNCN	ENSP00000379607⁴	STRING: ENSP00000379607
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0010452	histone H3-K36 methylation	ISS	--
GO:0018023	peptidyl-lysine trimethylation	ISS	--
GO:0018026	peptidyl-lysine monomethylation	ISS	--
GO:0018027	peptidyl-lysine dimethylation	ISS	--

SETD3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SETD3

Search CenterWatch for drugs/clinical trials and news about SETD3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SETD3 gene (2 alternative transcripts):

NM_032233.2 NM_199123.1

Unigene Cluster for SETD3:

SET domain containing 3

Hs.510407 [show with all ESTs]

Unigene Representative Sequence: AK302882

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000331768(uc001ygc.3) ENST00000446066 ENST00000489770 ENST00000453764

ENST00000329331(uc001ygd.3 uc021sbn.1) ENST00000436070(uc001ygf.3)

ENST00000357563 ENST00000453938

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SETD3
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate SETD3 (see all 21):
		hsa-miR-19b-2* hsa-miR-15a hsa-miR-216b hsa-miR-340 hsa-miR-877* hsa-miR-424 hsa-miR-7-1* hsa-miR-195

		SwitchGear 3'UTR luciferase reporter plasmid: SETD3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SETD3

Clone Products:		OriGene clones in human, mouse for SETD3 (see all 13) OriGene ORF clones in mouse, rat for SETD3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SETD3 (NM_032233)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD3
		Sirion Biotech Customized lentivirus for stable overexpression of SETD3 Customized lentivirus expression plasmids for stable overexpression of SETD3

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SETD3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SETD3

Additional mRNA sequence:

AK026680.1 AK302882.1 AL359581.2 BC009054.1 BC037395.1 BC066931.1 BC120967.1 BC120968.2

BC127624.1 BC127625.1 BC127644.1 BC142995.1 BC148251.1 BX161441.1 BX161471.1

18 DOTS entries:

DT.100848358 DT.409744 DT.98131677 DT.102827646 DT.456373 DT.91771725 DT.100841526 DT.95079238

DT.100044474 DT.100678063 DT.91771740 DT.97846885 DT.100658031 DT.100867385 DT.120788218 DT.120788279

DT.95079235 DT.95079228

24/314 AceView cDNA sequences (see all 314):

AA300089 BF476562 AI272032 BF475988 AI243225 AI769265 BF436914 BG236066

CB217137 AA228022 AV652746 AW439607 BE645783 BX161471 BU754571 BM849756

AI024925 AA032045 BM910387 CB156875 BU628428 AI674466 AI262224 BE779641

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SETD3 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	·	15c
SP1:															-		-				-						-								-
SP2:															-		-				-
SP3:									-						-		-				-
SP4:															-
SP5:															-		-				-

ECgene alternative splicing isoforms for SETD3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SETD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

See SETD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SETD3

SOURCE GeneReport for Unigene cluster: Hs.510407

SABiosciences Expression via Pathway-Focused PCR Array including SETD3:

Epigenetic Chromatin Modification Enzymes in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SETD3 gene from 10/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Setd3^{1 , 5}	SET domain containing 3^{1, 5}	87.44(n)¹ 92.57(a)¹		12 (59.23 cM)⁵ 52690¹ NM_028262.3¹ NP_082538.2¹ 108106431⁵
chicken (Gallus gallus)	Aves	LOC100859337¹	histone-lysine N-methyltransferase setd3-like	79.73(n) 85.64(a)		100859337 XM_003641411.1 XP_003641459.1
lizard (Anolis carolinensis)	Reptilia	-- SETD3⁶	Uncharacterized protein	83(a) 80(a)	possible ortholog 1 ↔ 1	GL343270.1(1848650-1863404) 1(10231662-10240368)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15711²	Xenopus laevis transcribed sequence with moderate similarity to protein refNP_115609.1 (H.sapiens) hypothetical protein FLJ23027 [Homo sapiens] less	80.87(n)		BJ030987.1
zebrafish (Danio rerio)	Actinopterygii	wufb01d12²	wufb01d12	75.34(n)		337193 BC055261.1
fruit fly (Drosophila melanogaster)	Insecta	CG32732¹	CG32732	45.73(n) 36.75(a)		31638 NM_167100.2 NP_727144.1
worm (Caenorhabditis elegans)	Secernentea	set-27¹	Protein SET-27	45.17(n) 33.41(a)		190607 NM_065203.2 NP_497604.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RKM4⁶	Ribosomal lysine methyltransferase specific for mo...	15(a)	1 → many	IV(969990-971474)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G14030¹	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase less	43.04(n) 29.92(a)		837964 NM_101269.2 NP_172856.1
rice (Oryza sativa)	Liliopsida	Os09g0411650¹	hypothetical protein	44.27(n) 34.95(a)		9266797 NM_001188905.1 NP_001175834.1

ENSEMBL Gene Tree for SETD3 (if available)
TreeFam Gene Tree for SETD3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SETD3 gene

SETD4²

SETD3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs57508281^1,2	C	--	80856138(+)	`CTGAT-/GTAGCCC`	1	--	int¹		2		NA CSA	4
rs185088500^1,2		--	99863635(+)	`TCCCAC/GAGCAT`	1	--	ds500¹		0	--	--	--	--
rs143502021^1,2	C	--	99863680(+)	`AAACAC/GTTGGG`	1	--	ds500¹		0	--	--	--	--
rs80354630^1,2	C,F	--	99863740(+)	`CAATGT/CGAAAA`	1	--	ds500¹		1		WA	118
rs189601011^1,2		--	99863777(+)	`GTAAAA/CCTGAA`	1	--	ds500¹		0	--	--	--	--
rs183327501^1,2		--	99863798(+)	`AGAAGA/GAGACA`	1	--	ds500¹		0	--	--	--	--
rs77933447^1,2	C,F	--	99863869(+)	`CTCCTT/CTTCTT`	1	--	ds500¹		1		WA	118
rs188705871^1,2		--	99863942(+)	`CCCACA/GGCTAT`	1	--	ds500¹		0	--	--	--	--
rs138450972^1,2		--	99863968(+)	`AGGTTA/CGCACA`	1	--	ds500¹		0	--	--	--	--
rs191982487^1,2		--	99863972(+)	`TAGCAC/TAGCCC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SETD3 (99864083 - 99947226 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for SETD3: About this table

Variant ID	Type	Subtype	PubMed ID
nsv902217	CNV	Loss	21882294
nsv832872	CNV	Loss	17160897
nsv832871	CNV	Gain	17160897
esv997017	OTHER	Inversion	20482838

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing SETD3

DNA2.0 Custom Variant and Variant Library Synthesis for SETD3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SETD3 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with SETD3)

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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A cohesin-RAD21 interactome. (PubMed id 22145905)¹ Panigrahi A.K....Pati D. (2012)
Histone methyltransferase SETD3 regulates muscle diffe rentiation. (PubMed id 21832073)¹ Eom G.H....Seo S.B. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (2011)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84193	HGNC: 20493	AceView: C14orf154	Ensembl:ENSG00000183576	euGenes: HUgn84193
ECgene: SETD3	H-InvDB: SETD3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SETD3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SETD3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SETD3 gene:
Search GeneIP for patents involving SETD3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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