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Set Analyses:

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SETD3 Gene

protein-coding GIFtS: 46
GCID: GC14M099864

SET Domain Containing 3

(Previous name: chromosome 14 open reading frame 154)
(Previous symbol: C14orf154)

Try our

MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
SET Domain Containing 3¹ ²
C14orf154¹ ² ³
SET Domain-Containing Protein 3² ³
Chromosome 14 Open Reading Frame 154¹
Histone-Lysine N-Methyltransferase Setd3²
EC 2.1.1.43³

External Ids:	HGNC: 20493¹	Entrez Gene: 84193²	Ensembl: ENSG00000183576⁷	OMIM: 615671⁵	UniProtKB: Q86TU7³

Export aliases for SETD3 gene to outside databases

Previous GC identifers: GC14M098934 GC14M080047

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SETD3 Gene:

SETD3 (SET domain containing 3) is a protein-coding gene. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and transcription coactivator activity. An important paralog of this gene is SETD4.

UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7

Function: Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation

represents a specific tag for epigenetic transcriptional activation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000014.8 NT_026437.13 NC_018925.2

Regulatory elements:

Regulatory transcription factor binding sites in the SETD3 gene promoter:
ER-alpha MAZR AML1a p53 POU6F1 (c2) Meis-1b FAC1 FOXO4 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SETD3 promoter sequence

Search Chromatin IP Primers for SETD3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SETD3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.2

SETD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETD3 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M099864: view genomic region (about GC identifiers)

Start:	99,864,083 bp from pter	End:	99,947,226 bp from pter
Size:	83,144 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7 (See protein sequence)

Recommended Name: Histone-lysine N-methyltransferase setd3

Size: 594 amino acids; 67257 Da

Sequence caution: Sequence=BAB15525.1; Type=Frameshift; Positions=486, 495;

1 PDB 3D structure from and Proteopedia for SETD3:

3SMT (3D)

Secondary accessions: A0PJU3 A5PLP0 B4DZE8 Q0VAQ2 Q659C0 Q86TU8 Q96GY9 Q9H5U5

Alternative splicing: 3 isoforms: Q86TU7-1 Q86TU7-2 Q86TU7-3

Explore the universe of human proteins at neXtProt for SETD3: NX_Q86TU7

Explore proteomics data for SETD3 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See SETD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_115609.2 NP_954574.1

ENSEMBL proteins:

ENSP00000327436 ENSP00000396870 ENSP00000398966 ENSP00000327910 ENSP00000408602

ENSP00000350174

SETD3 Human Recombinant Protein Products:

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	OriGene Purified Protein for SETD3 OriGene Protein Over-expression Lysate for SETD3 OriGene MassSpec for SETD3 OriGene Custom Protein Services for SETD3
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	Novus Biologicals SETD3 Protein Novus Biologicals SETD3 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for SETD3
	Search eBioscience for Proteins for SETD3
	Search GeneTex for Proteins for SETD3
	antibodies-online proteins for SETD3 (4 products)
	antibodies-online peptides for SETD3

SETD3 Antibody Products:

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	Novus Biologicals SETD3 Antibodies
	Abcam antibodies for SETD3
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	antibodies-online antibodies for SETD3 (15 products)

SETD3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SETD3
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	GenScript Custom Assay Services for SETD3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SETD3 Cloud-Clone Corp. CLIAs for SETD3
	Search eBioscience for ELISAs for SETD3
	antibodies-online kits for SETD3 (8 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

3 InterPro protein domains:

IPR001214 SET_dom

IPR015353 Rubisco_LSMT_subst-bd

IPR025785 Hist-Lys_N-MeTrfase_SETD3

Graphical View of Domain Structure for InterPro Entry Q86TU7

ProtoNet protein and cluster: Q86TU7

1 Blocks protein domain: IPB001214 Nuclear protein SET

UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7

Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine

methyltransferase family. SETD3 subfamily

Similarity: Contains 1 SET domain

Find genes that share domains with SETD3 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SETD3_HUMAN, Q86TU7

Function: Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation

represents a specific tag for epigenetic transcriptional activation (By similarity)

Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +

N(6)-methyl-L-lysine-[histone]

Enzyme Number (IUBMB): EC 2.1.1.43¹

Gene Ontology (GO): 5 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001102	RNA polymerase II activating transcription factor binding	IEA	--
GO:0003713	transcription coactivator activity	ISS	--
GO:0005515	protein binding	--	--
GO:0042800	histone methyltransferase activity (H3-K4 specific)	IEA	--
GO:0046975	histone methyltransferase activity (H3-K36 specific)	ISS	--

Find genes that share ontologies with SETD3 About GenesLikeMe

Phenotypes:
2 GenomeRNAi human phenotypes for SETD3:

G0/1 arrest

Increased G1 DNA content

1 MGI phenotypic allele

for Setd3 (no phenotypes)

Find genes that share phenotypes with SETD3 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for SETD3

miRNA Products:		miRTarBase miRNAs that target SETD3: hsa-mir-320a (MIRT044857), hsa-mir-34a-5p (MIRT025247)

		Block miRNA regulation of human, mouse, rat SETD3 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SETD3 (see all 21):
		hsa-miR-19b-2* hsa-miR-15a hsa-miR-216b hsa-miR-340 hsa-miR-877* hsa-miR-424 hsa-miR-7-1* hsa-miR-195

		SwitchGear 3'UTR luciferase reporter plasmid: SETD3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SETD3
		Predesigned siRNA for gene silencing in human, mouse, rat SETD3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SETD3

Clone Products:		OriGene clones in human, mouse for SETD3 (see all 11) OriGene ORF clones in mouse, rat for SETD3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SETD3 (NM_032233)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD3
		Addgene plasmids for SETD3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SETD3
		Browse ESI BIO Cell Lines and PureStem Progenitors for SETD3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

SETD3_HUMAN, Q86TU7: Nucleus (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
mitochondrion	2
nucleus	2
cytosol	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	IEA	--

Find genes that share ontologies with SETD3 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Pathway & Disease-focused RT² Profiler PCR Array including SETD3:

Epigenetic Chromatin Modification Enzymes in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for SETD3

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

Selected Interacting proteins for SETD3 (Q86TU7³ ENSP00000327436⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NR5A2	O00482³	I2D: score=5
RPL27	P61353³	I2D: score=5
MYOD1	ENSP00000250003⁴	STRING: ENSP00000250003
BCCIP	ENSP00000357748⁴	STRING: ENSP00000357748
KNCN	ENSP00000379607⁴	STRING: ENSP00000379607

About this table

Gene Ontology (GO): Selected biological process terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--
GO:0010452	histone H3-K36 methylation	ISS	--
GO:0018023	peptidyl-lysine trimethylation	ISS	--
GO:0018026	peptidyl-lysine monomethylation	ISS	--
GO:0018027	peptidyl-lysine dimethylation	ISS	--

Find genes that share ontologies with SETD3 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SETD3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for SETD3 gene (4 alternative transcripts):

NM_032233.2 NM_199123.1 XM_005268126.1 XM_005268127.1

Unigene Cluster for SETD3:

SET domain containing 3

Hs.510407 [show with all ESTs]

Unigene Representative Sequence: AK302882

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000331768(uc001ygc.3) ENST00000446066 ENST00000489770 ENST00000453764

ENST00000329331(uc001ygd.3 uc021sbn.1) ENST00000436070(uc001ygf.3)

ENST00000357563 ENST00000453938

miRNA Products:		Block miRNA regulation of human, mouse, rat SETD3 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SETD3 (see all 21):
		hsa-miR-19b-2* hsa-miR-15a hsa-miR-216b hsa-miR-340 hsa-miR-877* hsa-miR-424 hsa-miR-7-1* hsa-miR-195

		SwitchGear 3'UTR luciferase reporter plasmid: SETD3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SETD3
		Predesigned siRNA for gene silencing in human, mouse, rat SETD3

Clone Products:		OriGene clones in human, mouse for SETD3 (see all 11) OriGene ORF clones in mouse, rat for SETD3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SETD3 (NM_032233)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD3
		Addgene plasmids for SETD3

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SETD3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SETD3
		QuantiTect SYBR Green Assays in human, mouse, rat SETD3
		QuantiFast Probe-based Assays in human, mouse, rat SETD3

Additional mRNA sequence:

AK026680.1 AK302882.1 AL359581.2 BC009054.1 BC037395.1 BC066931.1 BC120967.1 BC120968.2

BC127624.1 BC127625.1 BC127644.1 BC142995.1 BC148251.1 BX161441.1 BX161471.1

18 DOTS entries:

DT.100848358 DT.409744 DT.98131677 DT.102827646 DT.456373 DT.91771725 DT.100841526 DT.95079238

DT.100044474 DT.100678063 DT.91771740 DT.97846885 DT.100658031 DT.100867385 DT.120788218 DT.120788279

DT.95079235 DT.95079228

Selected AceView cDNA sequences (see all 314):

AI216600 BC066931 AI628785 AA228022 AI024925 BF475988 CA307723 AI500313

BU618994 BX446097 BC009054 BQ000773 CB156875 BX359413 BM018617 AL359581

CD107577 N59259 AI399663 BC037395 W58691 BX161471 BM561712 BM910387

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for SETD3 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	·	15c
SP1:															-		-				-						-								-
SP2:															-		-				-
SP3:									-						-		-				-
SP4:															-
SP5:															-		-				-

ECgene alternative splicing isoforms for SETD3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SETD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

SETD3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SETD3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.510407

Pathway & Disease-focused RT² Profiler PCR Array including SETD3:

Epigenetic Chromatin Modification Enzymes in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SETD3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SETD3
		QuantiTect SYBR Green Assays in human, mouse, rat SETD3
		QuantiFast Probe-based Assays in human, mouse, rat SETD3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SETD3 gene from Selected species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Setd3^{1 , 5}	SET domain containing 3^{1, 5}	87.44(n)¹ 92.57(a)¹		12 (59.23 cM)⁵ 52690¹ NM_028262.3¹ NP_082538.2¹ 108106431⁵
chicken (Gallus gallus)	Aves	LOC100859337¹	histone-lysine N-methyltransferase setd3-like	79.73(n) 85.64(a)		100859337 XM_003641411.2 XP_003641459.2
lizard (Anolis carolinensis)	Reptilia	-- --	Uncharacterized protein	83(a) 80(a)	many → 1 many → 1	GL343270.1(1848650-1863404) 1(10231662-10240368)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15711²	Xenopus laevis transcribed sequence with moderate similarity to protein refNP_115609.1 (H.sapiens) hypothetical protein FLJ23027 [Homo sapiens] less	80.87(n)		BJ030987.1
zebrafish (Danio rerio)	Actinopterygii	wufb01d12²	wufb01d12	75.34(n)		337193 BC055261.1
fruit fly (Drosophila melanogaster)	Insecta	CG32732⁶	--	27(a)	1 ↔ 1	X(6852065-6862746)
worm (Caenorhabditis elegans)	Secernentea	set-27¹	set-27	45.37(n) 32.92(a)		190607 NM_065203.2 NP_497604.2

ENSEMBL Gene Tree for SETD3 (if available)
TreeFam Gene Tree for SETD3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for SETD3 gene

SETD4²

Find genes that share paralogs with SETD3 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs57508281^1,2	C	--	80856138(+)	`CTGAT-/GTAGCCC`	1	--	int¹		2		NA CSA	4
rs185088500^1,2		--	99863635(+)	`TCCCAC/GAGCAT`	1	--	ds500¹		0	--	--	--	--
rs143502021^1,2	C	--	99863680(+)	`AAACAC/GTTGGG`	1	--	ds500¹		0	--	--	--	--
rs80354630^1,2	C,F	--	99863740(+)	`CAATGT/CGAAAA`	1	--	ds500¹		1		WA	118
rs189601011^1,2		--	99863777(+)	`GTAAAA/CCTGAA`	1	--	ds500¹		0	--	--	--	--
rs183327501^1,2		--	99863798(+)	`AGAAGA/GAGACA`	1	--	ds500¹		0	--	--	--	--
rs77933447^1,2	C,F	--	99863869(+)	`CTCCTT/CTTCTT`	1	--	ds500¹		1		WA	118
rs188705871^1,2		--	99863942(+)	`CCCACA/GGCTAT`	1	--	ds500¹		0	--	--	--	--
rs138450972^1,2		--	99863968(+)	`AGGTTA/CGCACA`	1	--	ds500¹		0	--	--	--	--
rs191982487^1,2		--	99863972(+)	`TAGCAC/TAGCCC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SETD3 (99864083 - 99947226 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for SETD3: About this table

Variant ID	Type	Subtype	PubMed ID
nsv902217	CNV	Loss	21882294
nsv832872	CNV	Loss	17160897
nsv832871	CNV	Gain	17160897
esv997017	OTHER	Inversion	20482838

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SETD3

DNA2.0 Custom Variant and Variant Library Synthesis for SETD3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 615671 OMIM disorders: --

Find genes that share disorders with SETD3 About GenesLikeMe

Export disorders for SETD3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SETD3 gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with SETD3)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)¹ Varjosalo M....Gstaiger M. (Cell Rep 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
A cohesin-RAD21 interactome. (PubMed id 22145905)¹ Panigrahi A.K....Pati D. (Biochem. J. 2012)
Histone methyltransferase SETD3 regulates muscle differentiation. (PubMed id 21832073)¹ Eom G.H....Seo S.B. (J. Biol. Chem. 2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)
Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (Cell 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84193	HGNC: 20493	AceView: C14orf154	Ensembl:ENSG00000183576	euGenes: HUgn84193
ECgene: SETD3	H-InvDB: SETD3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SETD3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SETD3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SETD3 gene:
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GeneCards and IP:
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