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SETD3 Gene

protein-coding   GIFtS: 46
GCID: GC14M099864

SET Domain Containing 3

(Previous name: chromosome 14 open reading frame 154)
(Previous symbol: C14orf154)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SET Domain Containing 31 2
C14orf1541 2 3
SET Domain-Containing Protein 32 3
Chromosome 14 Open Reading Frame 1541
Histone-Lysine N-Methyltransferase Setd32
EC 2.1.1.433

External Ids:    HGNC: 204931   Entrez Gene: 841932   Ensembl: ENSG000001835767   OMIM: 6156715   UniProtKB: Q86TU73   

Export aliases for SETD3 gene to outside databases

Previous GC identifers: GC14M098934 GC14M080047


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SETD3 Gene:
SETD3 (SET domain containing 3) is a protein-coding gene. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and transcription coactivator activity. An important paralog of this gene is SETD4.

UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7
Function: Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation
represents a specific tag for epigenetic transcriptional activation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SETD3 gene promoter:
         ER-alpha   MAZR   AML1a   p53   POU6F1 (c2)   Meis-1b   FAC1   FOXO4   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSETD3 promoter sequence
   Search Chromatin IP Primers for SETD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SETD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

SETD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETD3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M099864:  view genomic region     (about GC identifiers)

Start:
99,864,083 bp from pter      End:
99,947,226 bp from pter
Size:
83,144 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase setd3  
Size: 594 amino acids; 67257 Da
Sequence caution: Sequence=BAB15525.1; Type=Frameshift; Positions=486, 495;
1 PDB 3D structure from and Proteopedia for SETD3:
3SMT (3D)    
Secondary accessions: A0PJU3 A5PLP0 B4DZE8 Q0VAQ2 Q659C0 Q86TU8 Q96GY9 Q9H5U5
Alternative splicing: 3 isoforms:  Q86TU7-1   Q86TU7-2   Q86TU7-3   

Explore the universe of human proteins at neXtProt for SETD3: NX_Q86TU7

Explore proteomics data for SETD3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SETD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_115609.2  NP_954574.1  

    ENSEMBL proteins: 
     ENSP00000327436   ENSP00000396870   ENSP00000398966   ENSP00000327910   ENSP00000408602  
     ENSP00000350174  

    SETD3 Human Recombinant Protein Products:

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    OriGene Purified Protein for SETD3
    OriGene Protein Over-expression Lysate for SETD3
    OriGene MassSpec for SETD3
    OriGene Custom Protein Services for SETD3
    GenScript Custom Purified and Recombinant Proteins Services for SETD3
    Novus Biologicals SETD3 Protein
    Novus Biologicals SETD3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SETD3

     
    Search eBioscience for Proteins for SETD3 

     
    antibodies-online proteins for SETD3 (4 products) 

     
    antibodies-online peptides for SETD3

    SETD3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for SETD3 (15 products) 

    SETD3 Assay Products:

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    Cloud-Clone Corp. ELISAs for SETD3
    Cloud-Clone Corp. CLIAs for SETD3
    Search eBioscience for ELISAs for SETD3 
    antibodies-online kits for SETD3 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001214 SET_dom
     IPR015353 Rubisco_LSMT_subst-bd
     IPR025785 Hist-Lys_N-MeTrfase_SETD3

    Graphical View of Domain Structure for InterPro Entry Q86TU7

    ProtoNet protein and cluster: Q86TU7

    1 Blocks protein domain: IPB001214 Nuclear protein SET

    UniProtKB/Swiss-Prot: SETD3_HUMAN, Q86TU7
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. SETD3 subfamily
    Similarity: Contains 1 SET domain


    Find genes that share domains with SETD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SETD3_HUMAN, Q86TU7
    Function: Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation
    represents a specific tag for epigenetic transcriptional activation (By similarity)
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Number (IUBMB): EC 2.1.1.431

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001102RNA polymerase II activating transcription factor binding IEA--
    GO:0003713transcription coactivator activity ISS--
    GO:0005515protein binding ----
    GO:0042800histone methyltransferase activity (H3-K4 specific) IEA--
    GO:0046975histone methyltransferase activity (H3-K36 specific) ISS--
         
    Find genes that share ontologies with SETD3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SETD3:
     G0/1 arrest  Increased G1 DNA content 

         1 MGI phenotypic allele for Setd3 (no phenotypes)

    Find genes that share phenotypes with SETD3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SETD3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SETD3:
    hsa-mir-320a (MIRT044857), hsa-mir-34a-5p (MIRT025247)

    Block miRNA regulation of human, mouse, rat SETD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SETD3 (see all 21):
    hsa-miR-19b-2* hsa-miR-15a hsa-miR-216b hsa-miR-340 hsa-miR-877* hsa-miR-424 hsa-miR-7-1* hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidSETD3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SETD3
    Predesigned siRNA for gene silencing in human, mouse, rat SETD3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SETD3

    Clone
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    OriGene ORF clones in mouse, rat for SETD3
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    GenScript: all cDNA clones in your preferred vector (see all 2): SETD3 (NM_032233)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD3
    Addgene plasmids for SETD3 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SETD3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SETD3_HUMAN, Q86TU7: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    nucleus2
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--

    Find genes that share ontologies with SETD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including SETD3: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SETD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for SETD3 (Q86TU73 ENSP000003274364) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR5A2O004823I2D: score=5 
    RPL27P613533I2D: score=5 
    MYOD1ENSP000002500034STRING: ENSP00000250003
    BCCIPENSP000003577484STRING: ENSP00000357748
    KNCNENSP000003796074STRING: ENSP00000379607
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0010452histone H3-K36 methylation ISS--
    GO:0018023peptidyl-lysine trimethylation ISS--
    GO:0018026peptidyl-lysine monomethylation ISS--
    GO:0018027peptidyl-lysine dimethylation ISS--

    Find genes that share ontologies with SETD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SETD3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SETD3 gene (2 alternative transcripts): 
    NM_032233.2  NM_199123.1  

    Unigene Cluster for SETD3:

    SET domain containing 3
    Hs.510407  [show with all ESTs]
    Unigene Representative Sequence: AK302882
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331768(uc001ygc.3) ENST00000446066 ENST00000489770 ENST00000453764
    ENST00000329331(uc001ygd.3 uc021sbn.1) ENST00000436070(uc001ygf.3)
    ENST00000357563 ENST00000453938
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SETD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SETD3 (see all 21):
    hsa-miR-19b-2* hsa-miR-15a hsa-miR-216b hsa-miR-340 hsa-miR-877* hsa-miR-424 hsa-miR-7-1* hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidSETD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SETD3
    Predesigned siRNA for gene silencing in human, mouse, rat SETD3
    Clone
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    OriGene clones in human, mouse for SETD3 (see all 11)
    OriGene ORF clones in mouse, rat for SETD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SETD3 (NM_032233)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD3
    Addgene plasmids for SETD3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SETD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SETD3
      QuantiTect SYBR Green Assays in human, mouse, rat SETD3
      QuantiFast Probe-based Assays in human, mouse, rat SETD3

    Additional mRNA sequence: 

    AK026680.1 AK302882.1 AL359581.2 BC009054.1 BC037395.1 BC066931.1 BC120967.1 BC120968.2 
    BC127624.1 BC127625.1 BC127644.1 BC142995.1 BC148251.1 BX161441.1 BX161471.1 

    18 DOTS entries:

    DT.100848358  DT.409744  DT.98131677  DT.102827646  DT.456373  DT.91771725  DT.100841526  DT.95079238 
    DT.100044474  DT.100678063  DT.91771740  DT.97846885  DT.100658031  DT.100867385  DT.120788218  DT.120788279 
    DT.95079235  DT.95079228 

    Selected AceView cDNA sequences (see all 314):

    AI216600 BC066931 AI628785 AA228022 AI024925 BF475988 CA307723 AI500313 
    BU618994 BX446097 BC009054 BQ000773 CB156875 BX359413 BM018617 AL359581 
    CD107577 N59259 AI399663 BC037395 W58691 BX161471 BM561712 BM910387 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SETD3 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c
    SP1:                                            -     -           -                 -                       -                           
    SP2:                                            -     -           -                                                                     
    SP3:                          -                 -     -           -                                                                     
    SP4:                                            -                                                                                       
    SP5:                                            -     -           -                                                                     


    ECgene alternative splicing isoforms for SETD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SETD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SETD3 Expression
    About this image

    SETD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SETD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.510407
        Pathway & Disease-focused RT2 Profiler PCR Array including SETD3: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SETD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SETD3
    QuantiTect SYBR Green Assays in human, mouse, rat SETD3
    QuantiFast Probe-based Assays in human, mouse, rat SETD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SETD3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Setd31 , 5 SET domain containing 31, 5 87.44(n)1
    92.57(a)1
      12 (59.23 cM)5
    526901  NM_028262.31  NP_082538.21 
     1081064315 
    chicken
    (Gallus gallus)
    Aves LOC1008593371 histone-lysine N-methyltransferase setd3-like 79.73(n)
    85.64(a)
      100859337  XM_003641411.2  XP_003641459.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    83(a)
    80(a)
    many → 1
    many → 1
    GL343270.1(1848650-1863404)
    1(10231662-10240368)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.157112 Xenopus laevis transcribed sequence with moderate similarity more 80.87(n)    BJ030987.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb01d122 wufb01d12 75.34(n)   337193  BC055261.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG327326
    --
    27(a)
    1 ↔ 1
    X(6852065-6862746)
    worm
    (Caenorhabditis elegans)
    Secernentea set-271 set-27 45.37(n)
    32.92(a)
      190607  NM_065203.2  NP_497604.2 


    ENSEMBL Gene Tree for SETD3 (if available)
    TreeFam Gene Tree for SETD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SETD3 gene
    SETD42  

    Find genes that share paralogs with SETD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SETD3 (see all 1650)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs575082811,2
    C--80856138(+) CTGAT-/GTAGCCC 1 -- int12Minor allele frequency- GT:0.25NA CSA 4
    rs1850885001,2
    --99863635(+) TCCCAC/GAGCAT 1 -- ds50010--------
    rs1435020211,2
    C--99863680(+) AAACAC/GTTGGG 1 -- ds50010--------
    rs803546301,2
    C,F--99863740(+) CAATGT/CGAAAA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1896010111,2
    --99863777(+) GTAAAA/CCTGAA 1 -- ds50010--------
    rs1833275011,2
    --99863798(+) AGAAGA/GAGACA 1 -- ds50010--------
    rs779334471,2
    C,F--99863869(+) CTCCTT/CTTCTT 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1887058711,2
    --99863942(+) CCCACA/GGCTAT 1 -- ds50010--------
    rs1384509721,2
    --99863968(+) AGGTTA/CGCACA 1 -- ds50010--------
    rs1919824871,2
    --99863972(+) TAGCAC/TAGCCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SETD3 (99864083 - 99947226 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SETD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv902217CNV Loss21882294
    nsv832872CNV Loss17160897
    nsv832871CNV Gain17160897
    esv997017OTHER Inversion20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615671    OMIM disorders: --


    Find genes that share disorders with SETD3           About GenesLikeMe


    Export disorders for SETD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SETD3 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SETD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (Biochem. J. 2012)
    6. Histone methyltransferase SETD3 regulates muscle differentiation. (PubMed id 21832073)1 Eom G.H....Seo S.B. (J. Biol. Chem. 2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84193 HGNC: 20493 AceView: C14orf154 Ensembl:ENSG00000183576 euGenes: HUgn84193
    ECgene: SETD3 H-InvDB: SETD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SETD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SETD3 gene:
    Search GeneIP for patents involving SETD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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