Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SETD2 Gene

protein-coding   GIFtS: 66
GCID: GC03M047033

SET Domain Containing 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SET Domain Containing 21 2     EC 2.1.1.433 8
HYPB2 3 5     HBP2312 5
SET22 3 5     KIAA17323 5
Huntingtin Yeast Partner B2 3     Histone-Lysine N-Methyltransferase SETD22
Huntingtin-Interacting Protein B2 3     Huntingtin Interacting Protein 12
Lysine N-Methyltransferase 3A2 3     HIF13
HIF-12 3     hSET23
HIP-12 3     Huntingtin-Interacting Protein 13
KMT3A2 3     SET Domain-Containing Protein 23
p231HBP2 3     

External Ids:    HGNC: 184201   Entrez Gene: 290722   Ensembl: ENSG000001815557   OMIM: 6127785   UniProtKB: Q9BYW23   

Export aliases for SETD2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SETD2 Gene:
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an
expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class
of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that
is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin.
This protein also contains a novel transcriptional activation domain and has been found associated with
hyperphosphorylated RNA polymerase II. (provided by RefSeq, Aug 2008)

GeneCards Summary for SETD2 Gene:
SETD2 (SET domain containing 2) is a protein-coding gene. Diseases associated with SETD2 include retinal ischemia, and endolymphatic sac tumor. GO annotations related to this gene include histone-lysine N-methyltransferase activity. An important paralog of this gene is NSD1.

UniProtKB/Swiss-Prot: SETD2_HUMAN, Q9BYW2
Function: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using
dimethylated 'Lys-36' (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for
epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by
coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key
regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6
subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated
allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an
essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A.
H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing
and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis. Recruited
to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression

Gene Wiki entry for SETD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SETD2 gene promoter:
         Sp1   NRSF form 1   AP-4   NRSF form 2   SREBP-1b   SREBP-1a   FOXO4   ARP-1   Sox9   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSETD2 promoter sequence
   Search Chromatin IP Primers for SETD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SETD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

SETD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETD2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M047033:  view genomic region     (about GC identifiers)

Start:
47,057,898 bp from pter      End:
47,205,467 bp from pter
Size:
147,570 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SETD2_HUMAN, Q9BYW2 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SETD2  
Size: 2564 amino acids; 287597 Da
Subunit: Specifically interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large
subunit (POLR2A): binds to CTD heptad repeats doubly phosphorylated on 'Ser-2' and 'Ser-5' of each heptad.
Interacts with HTT and IWS1. Interacts with p53/TP53; leading to regulate p53/TP53 target genes. Component of a
complex with HNRNPL
Sequence caution: Sequence=AAF29041.1; Type=Frameshift; Positions=Several; Sequence=AAH72440.1; Type=Erroneous
termination; Positions=463; Note=Translated as Glu; Sequence=AAI17163.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=AAI17165.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=AAT77612.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAT77613.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15367.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15367.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAC87131.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=CAC28349.1; Type=Erroneous termination;
Positions=385; Note=Translated as Arg; Sequence=CAD38601.2; Type=Erroneous initiation; Note=Translation
N-terminally extended;
3 PDB 3D structures from and Proteopedia for SETD2:
2A7O (3D)        4FMU (3D)        4H12 (3D)    
Secondary accessions: O75397 O75405 Q17RW8 Q5BKS9 Q5QGN2 Q69YI5 Q6IN64 Q6ZN53 Q6ZS25 Q8N3R0
Q8TCN0 Q9C0D1 Q9H696 Q9NZW9
Alternative splicing: 3 isoforms:  Q9BYW2-1   Q9BYW2-2   Q9BYW2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SETD2: NX_Q9BYW2

Explore proteomics data for SETD2 at MOPED

Post-translational modifications: 

  • May be automethylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for SETD2 (Q9BYW2)
     RFMNHSC  NHSCEPN 


    See SETD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054878.5  
    ENSEMBL proteins: 
     ENSP00000388349   ENSP00000332415   ENSP00000411901   ENSP00000386759   ENSP00000416401  

    SETD2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SETD2
    GenScript Custom Purified and Recombinant Proteins Services for SETD2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SETD2

    SETD2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SETD2
    Novus Biologicals SETD2 Antibodies
    Abcam antibodies for SETD2
    Cloud-Clone Corp. Antibodies for SETD2
    ThermoFisher Antibodies for SETD2
    LSBio Antibodies in human, mouse, rat for SETD2

    SETD2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SETD2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SETD2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SETD2
    Cloud-Clone Corp. CLIAs for SETD2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    KMT: Chromatin-modifying enzymes / K-methyltransferases

    5 InterPro protein domains:
     IPR001214 SET_dom
     IPR003616 Post-SET_dom
     IPR013257 SRI
     IPR001202 WW_dom
     IPR006560 AWS

    Graphical View of Domain Structure for InterPro Entry Q9BYW2

    ProtoNet protein and cluster: Q9BYW2

    1 Blocks protein domain: IPB001214 Nuclear protein SET

    UniProtKB/Swiss-Prot: SETD2_HUMAN, Q9BYW2
    Domain: The low charge region mediates the transcriptional activation activity (PubMed:16118227)
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. SET2 subfamily
    Similarity: Contains 1 AWS domain
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 SET domain
    Similarity: Contains 1 WW domain


    SETD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SETD2_HUMAN, Q9BYW2
    Function: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using
    dimethylated 'Lys-36' (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for
    epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by
    coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key
    regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6
    subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated
    allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an
    essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A.
    H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing
    and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis. Recruited
    to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]
    Enzyme regulation: Specifically inhibited by sinefungin derivatives. N-propyl sinefungin (Pr-SNF) interacts
    preferentially with SETD2
    Biophysicochemical properties: Kinetic parameters: KM=1.21 uM for S-adenosyl-L-methionine; KM=0.42 uM for histone
    H3; Note=Kcat is 0.14 min(-1);

         Enzyme Number (IUBMB): EC 2.1.1.431 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17500595
    GO:0018024histone-lysine N-methyltransferase activity IMP--
         
    SETD2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SETD2:
     G0/1 arrest  Increased G1 DNA content  Increased cell size 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Setd2):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  nervous system 

    SETD2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Setd2tm1Zhch for SETD2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SETD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SETD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SETD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SETD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SETD2:
    hsa-mir-26a-5p (MIRT050126), hsa-mir-106b-5p (MIRT044337)

    Block miRNA regulation of human, mouse, rat SETD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SETD2 (see all 29):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-548i hsa-miR-520d-5p hsa-miR-374a hsa-miR-374c hsa-miR-7-1* hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidSETD2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SETD2
    Predesigned siRNA for gene silencing in human, mouse, rat SETD2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SETD2

    Clone
    Products:
         
    OriGene clones in human, mouse for SETD2 (see all 8)
    OriGene ORF clones in mouse, rat for SETD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SETD2 (NM_014159)
    Sino Biological Human cDNA Clone for SETD2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SETD2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SETD2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SETD2_HUMAN, Q9BYW2: Nucleus (Probable). Chromosome (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005694chromosome IEA--

    SETD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SETD2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Lysine degradation
    Lysine degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for SETD2):
        Lysine degradation


    SETD2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SETD2: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SETD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SETD2 (Q9BYW21, 2, 3 ENSP000003867594) via UniProtKB, MINT, STRING, and/or I2D (see all 301)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001570vasculogenesis ----
    GO:0001763morphogenesis of a branching structure IEA--
    GO:0001843neural tube closure IEA--
    GO:0006298mismatch repair IMP--

    SETD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SETD2

    3 HMDB Compounds for SETD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Lysine(+)-S-Lysine (see all 25)56-87-1--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    Selected Novoseek inferred chemical compound relationships for SETD2 gene (see all 95)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 87.7 443 12070140 (7), 18305118 (5), 16491827 (5), 19959878 (5) (see all 99)
    cobalt chloride 81.8 17 19374849 (1), 19428442 (1), 10085152 (1), 16490744 (1) (see all 13)
    oxygen 79.5 361 16144688 (4), 19007879 (4), 12678687 (3), 17942596 (3) (see all 99)
    cocl2 72.2 11 9804609 (3), 17268062 (1), 18639543 (1), 16309584 (1) (see all 8)
    deferoxamine 70.2 30 9115299 (3), 9804609 (3), 18061585 (2), 12015365 (2) (see all 15)
    pimonidazole 65.9 2 19459851 (1), 17289019 (1)
    echinomycin 64.5 8 17916190 (4), 16772336 (1), 19671732 (1), 19996311 (1)
    ly294002 60.6 16 15631803 (2), 10749120 (1), 11457733 (1), 17576198 (1) (see all 9)
    alpha-ketoglutarate 59.5 10 16223732 (1), 16847457 (1), 18252725 (1), 16883594 (1) (see all 9)
    deguelin 59.4 2 18208562 (1)



    SETD2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SETD2 gene (2 alternative transcripts): 
    NM_014159.6  NM_012271.1  

    Unigene Cluster for SETD2:

    SET domain containing 2
    Hs.517941  [show with all ESTs]
    Unigene Representative Sequence: NM_014159
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431180(uc003cqr.3 uc003cqt.1) ENST00000330022 ENST00000445387
    ENST00000409792(uc003cqs.3 uc003cqv.3) ENST00000479832 ENST00000492397
    ENST00000484689 ENST00000412450
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SETD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SETD2 (see all 29):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-548i hsa-miR-520d-5p hsa-miR-374a hsa-miR-374c hsa-miR-7-1* hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidSETD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SETD2
    Predesigned siRNA for gene silencing in human, mouse, rat SETD2
    Clone
    Products:
         
    OriGene clones in human, mouse for SETD2 (see all 8)
    OriGene ORF clones in mouse, rat for SETD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SETD2 (NM_014159)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SETD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SETD2
      QuantiTect SYBR Green Assays in human, mouse, rat SETD2
      QuantiFast Probe-based Assays in human, mouse, rat SETD2

    Additional mRNA sequence: 

    AB051519.2 AF049103.1 AF049610.1 AF161554.1 AJ238403.1 AK026125.1 AK026837.1 AK091413.1 
    AK095494.1 AK127782.1 AK128096.1 AK131371.1 AL713692.1 AL833394.1 AY576987.1 BC072440.1 
    BC090954.1 BC117162.1 BC117164.1 BX649110.1 

    11 DOTS entries:

    DT.447505  DT.100823976  DT.97763312  DT.100823973  DT.120912104  DT.92442690  DT.311074  DT.91792863 
    DT.102832745  DT.95112638  DT.99969069 

    Selected AceView cDNA sequences (see all 356):

    AI868267 BX649110 AB051519 CB070242 AA044733 CK000213 BM783589 AL037842 
    BG762131 BE336938 AK128096 BQ778331 AK026837 BX112692 BQ882307 CR604129 
    BQ709669 CA776223 BI868651 AA705510 AK127782 BE740558 BM806385 AA831489 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SETD2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
    SP1:                    -                                   -                                                           -     -     -                           
    SP2:                                      -                 -                                                           -     -     -           -               
    SP3:                    -                                   -                                                           -     -     -           -               
    SP4:                                                                                                                    -     -     -           -               
    SP5:                                                                                                                    -     -                 -               

    ExUns: 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:  -     -                                             
    SP5:                                                      


    ECgene alternative splicing isoforms for SETD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SETD2 expression in normal human tissues (normalized intensities)      SETD2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATATTCC
    SETD2 Expression
    About this image


    SETD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Brain (Nervous System)
             Cerebral Cortex
    SETD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SETD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517941

    UniProtKB/Swiss-Prot: SETD2_HUMAN, Q9BYW2
    Tissue specificity: Ubiquitously expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including SETD2: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SETD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SETD2
    QuantiTect SYBR Green Assays in human, mouse, rat SETD2
    QuantiFast Probe-based Assays in human, mouse, rat SETD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SETD2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Setd21 , 5 SET domain containing 21, 5 87.27(n)1
    86.29(a)1
      9 (60.00 cM)5
    2356261  NM_001081340.21  NP_001074809.21 
     1105325975 
    chicken
    (Gallus gallus)
    Aves SETD21 SET domain containing 2 67.84(n)
    67.8(a)
      420404  XM_004939104.1  XP_004939161.1 
    lizard
    (Anolis carolinensis)
    Reptilia SETD26
    SET domain containing 2
    60(a)
    1 ↔ 1
    GL343918.1(47324-113132)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.261092 Xenopus laevis transcribed sequence with weak similarity more 73.12(n)    CD326773.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb97h092 Transcribed sequence with weak similarity to protein more 77.69(n)    57076336 
    fruit fly
    (Drosophila melanogaster)
    Insecta Set26
    Set2
    20(a)
    many ↔ many
    X(13307275-13315057)
    worm
    (Caenorhabditis elegans)
    Secernentea met-16
    Protein MET-1, isoform b (met-1) mRNA, complete cd...
    24(a)
    1 ↔ 1
    I(4254380-4264683) WBGene00016603
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SET2(YJL168C)4 Histone methyltransferase with a role in transcriptional more   --   10(104428-102227) 853271  NP_012367.1 


    ENSEMBL Gene Tree for SETD2 (if available)
    TreeFam Gene Tree for SETD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SETD2 gene
    NSD12  ASH1L2  WHSC12  WHSC1L12  SUV39H22  SETBP12  SETDB22  SUV39H12  
    EHMT12  EHMT22  SETMAR2  SETDB12  
    2 SIMAP similar genes for SETD2 using alignment to 5 protein entries:     SETD2_HUMAN (see all proteins):
    DKFZp686C08112    FP13812

    SETD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SETD2 (see all 2636)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs121076421,2
    C,A--46988372(+) CCCCCA/CAAAAA 1 -- ds50016Minor allele frequency- C:0.33NA WA 130
    rs750314831,2
    F--46988478(+) ATTTGC/ACTTTC 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1908032601,2
    --46988545(+) CTGCTG/TCTTTT 1 -- ds50010--------
    rs1834429341,2
    --46988869(+) AATTGC/GATAAA 1 -- ut310--------
    rs117082571,2
    C,F,A,H--46988952(+) GCTTTG/AGAATA 1 -- ut31 ese324Minor allele frequency- A:0.07NS EA NA WA CSA 2058
    rs1886211971,2
    --46988998(+) TTAAAC/TTGTCC 1 -- ut310--------
    rs1928107911,2
    --46989290(+) ACAACC/TAGGTA 1 -- ut310--------
    rs1999733301,2
    --46989585(+) CTCCAA/GGTCCT 2 L syn10--------
    rs1123086021,2
    F--46989692(+) AATTAC/TATGAG 1 -- int11Minor allele frequency- T:0.50CSA 4
    rs1484998351,2
    C,F--46990056(+) GTTGTG/AGTAAT 2 /T syn12Minor allele frequency- A:0.00NA EU 5873

    HapMap Linkage Disequilibrium report for SETD2 (47057898 - 47205467 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SETD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725239CNV Deletion23290073
    nsv3801CNV Loss18451855
    nsv876755CNV Loss21882294
    nsv428417CNV Loss18775914
    nsv876757CNV Loss21882294
    nsv876756CNV Gain21882294

    Human Gene Mutation Database (HGMD): SETD2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SETD2
    DNA2.0 Custom Variant and Variant Library Synthesis for SETD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612778    OMIM disorders: --

    UniProtKB/Swiss-Prot: SETD2_HUMAN, Q9BYW2
  • Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or
    hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear
    cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma,
    collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear
    cell renal cell carcinoma is the most common subtype. Note=The disease may be caused by mutations affecting the
    gene represented in this entry. Defects of SETD2 are associated with loss of DNA methylation at non-promoter
    regions (PubMed:23792563)

  • Selected diseases for SETD2 (see all 88):    About MalaCards
    retinal ischemia    endolymphatic sac tumor    huntington's disease    cerebral artery occlusion
    ankylosis    erythrocytosis    renal clear cell carcinoma    cellulitis
    ischemia    anoxia    von hippel-lindau disease    choroiditis
    headache    proliferative diabetic retinopathy    glioblastoma multiforme    fibrosarcoma
    hypoxia    malignant glioma    cervical cancer    hypoglycemia


    SETD2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for SETD2 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    solid tumor 70.3 27 19098000 (2), 12914934 (1), 15127725 (1), 19479945 (1) (see all 22)
    tumors 69.5 485 16098463 (7), 17280792 (5), 15141023 (5), 11868612 (4) (see all 99)
    cancer 66 247 16899626 (4), 15135470 (3), 15901372 (3), 19946328 (3) (see all 99)
    renal clear cell carcinoma 55.1 4 16515534 (1), 15220362 (1), 16510593 (1), 17551816 (1)
    neovascularization 53 11 19075673 (3), 20065104 (1), 10605934 (1), 18834862 (1) (see all 9)
    retinal ischemia 47.5 2 15728570 (1), 11328942 (1)
    metastasis 45.2 45 18635960 (2), 17933687 (2), 15930314 (1), 16861921 (1) (see all 42)
    oxygen deficiency 44.2 2 16596228 (1), 19671044 (1)
    retinal neovascularization 44.2 1 20008515 (1), 18704312 (1)
    carcinoma renal cell 41.5 10 17482131 (2), 17989922 (1), 20185296 (1), 16778202 (1) (see all 9)

    Genetic Association Database (GAD): SETD2
    Human Genome Epidemiology (HuGE) Navigator: SETD2 (1 document)

    Export disorders for SETD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SETD2 gene, integrated from 10 sources (see all 950):
    (articles sorted by number of sources associating them with SETD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel human histone H3 lysine 36 specific methyltransferase. (PubMed id 16118227)1, 2, 3 Sun X.-J.... Chen Z. (J. Biol. Chem. 2005)
    2. Identification of the full-length huntingtin-interacting protein p231HBP/HYPB as a DNA-binding factor. (PubMed id 11461154)1, 2, 3 Rega S.... Puetzer B.M. (Mol. Cell. Neurosci. 2001)
    3. Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription. (PubMed id 23325844)1, 2 Carvalho S....de Almeida S.F. (Nucleic Acids Res. 2013)
    4. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. (PubMed id 20054297)1, 2 Dalgliesh G.L....Futreal P.A. (Nature 2010)
    5. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    6. The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. (PubMed id 19141475)1, 2 Yoh S.M....Jones K.A. (amp 2008)
    7. Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes. (PubMed id 18585004)1, 2 Xie P....He F. (Cell. Signal. 2008)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1. (PubMed id 16314571)1, 2 Li M.... Zhou P. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29072 HGNC: 18420 AceView: HYPB Ensembl:ENSG00000181555 euGenes: HUgn29072
    ECgene: SETD2 Kegg: 29072 H-InvDB: SETD2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1732

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SETD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SETD2 gene:
    Search GeneIP for patents involving SETD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SETD2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SETD2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SETD2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SETD2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SETD2   OriGene Custom Protein Services for SETD2  

     
     
     Block miRNA regulation of human, mouse, rat SETD2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SETD2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SETD2 Predesigned siRNA for gene silencing in human, mouse, rat SETD2
     QuantiFast Probe-based Assays in human, mouse, rat SETD2 QuantiTect SYBR Green Assays in human, mouse, rat SETD2
     PCR Arrays including human, mouse, rat SETD2 Search Chromatin IP Primers for SETD2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SETD2  GeneGlobe Interaction Network for SETD2
     Regulatory tfbs in SETD2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SETD2 GenScript cDNA clones with any tag delivered in your preferred vector for SETD2
     GenScript Custom Assay Services for SETD2 GenScript Custom overexpressing Cell Line Services for SETD2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SETD2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SETD2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SETD2 antibodies
     Antibodies for SETD2
     See all of Abcam's Antibodies, Kits and Proteins for SETD2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SETD2
     Antibodies for SETD2
     ELISAs for SETD2
     CLIAs for SETD2



     Browse ESI BIO Cell Lines and PureStem Progenitors for SETD2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD2
     SwitchGear 3'UTR luciferase reporter plasmids for SETD2
     SwitchGear Promoter luciferase reporter plasmids for SETD2
     ThermoFisher Antibodies for SETD2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SETD2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SETD2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SETD2
     LSBio Antibodies in human, mouse, rat for SETD2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SETD2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4