Aliases for SETD1B Gene
External Ids for SETD1B Gene
Previous GeneCards Identifiers for SETD1B Gene
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SETD1B Gene
SETD1B (SET Domain Containing 1B) is a Protein Coding gene. Among its related pathways are Lysine degradation. GO annotations related to this gene include RNA binding and histone methyltransferase activity (H3-K4 specific). An important paralog of this gene is KMT2C.
UniProtKB/Swiss-Prot for SETD1B Gene
Histone methyltransferase that specifically methylates Lys-4 of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring Lys-9 residue is already methylated. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates Lys-4 of histone H3 in vitro