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SETD1B Gene

protein-coding   GIFtS: 50
GCID: GC12P122243

SET Domain Containing 1B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SET Domain Containing 1B1 2     KIAA10763 5
Lysine N-Methyltransferase 2G2 3     SET1B3 5
KMT2G2 3     Set1B2
hSET1B2 3     Histone-Lysine N-Methyltransferase SETD1B2
SET Domain-Containing Protein 1B2 3     EC 2.1.18
EC 2.1.1.433 8     

External Ids:    HGNC: 291871   Entrez Gene: 230672   Ensembl: ENSG000001397187   OMIM: 6110555   UniProtKB: Q9UPS63   

Export aliases for SETD1B gene to outside databases

Previous GC identifers: GC12P120726 GC12P119254


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SETD1B Gene:
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et
al., 2007 (PubMed 17355966)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SETD1B Gene:
SETD1B (SET domain containing 1B) is a protein-coding gene. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and RNA binding. An important paralog of this gene is KMT2D.

UniProtKB/Swiss-Prot: SET1B_HUMAN, Q9UPS6
Function: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1
histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3
'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping
localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic
control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SETD1B gene promoter:
         AhR   USF1   MyoD   Olf-1   Lmo2   Ik-3   AREB6   HOXA5   USF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SETD1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SETD1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

SETD1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETD1B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P122243:  view genomic region     (about GC identifiers)

Start:
122,242,086 bp from pter      End:
122,270,562 bp from pter
Size:
28,477 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SET1B_HUMAN, Q9UPS6 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SETD1B  
Size: 1966 amino acids; 212803 Da
Subunit: Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5,
WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with HCFC1 and ASH2L/ASH2. Interacts (via the
RRM domain) with WDR82. Interacts (via the RRM domain) with hyperphosphorylated C-terminal domain (CTD) of RNA
polymerase II large subunit (POLR2A) only in the presence of WDR82. Binds specifically to CTD heptad repeats
phosphorylated on 'Ser-5' of each heptad. Interacts with RBM15
2 PDB 3D structures from and Proteopedia for SETD1B:
3UVO (3D)        4ES0 (3D)    
Secondary accessions: F6MFW1
Alternative splicing: 2 isoforms:  Q9UPS6-1   Q9UPS6-2   

Explore the universe of human proteins at neXtProt for SETD1B: NX_Q9UPS6

Explore proteomics data for SETD1B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SETD1B (Q9UPS6) (see all 26)
     FDEWWDK  ISSSSSQ  TGCARSE  KLYRYDG 


    See SETD1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055863.1  
    ENSEMBL proteins: 
     ENSP00000474253   ENSP00000442924   ENSP00000267197  

    SETD1B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SETD1B

     
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    Cloud-Clone Corp. ELISAs for SETD1B
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    Search eBioscience for ELISAs for SETD1B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KMT: Chromatin-modifying enzymes / K-methyltransferases
    RBM: RNA binding motif (RRM) containing

    Selected InterPro protein domains (see all 6):
     IPR001214 SET_dom
     IPR003616 Post-SET_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR024657 COMPASS_Set1_N-SET
     IPR015722 Histone-lysine_MeTfrase

    Graphical View of Domain Structure for InterPro Entry Q9UPS6

    ProtoNet protein and cluster: Q9UPS6

    1 Blocks protein domain: IPB001214 Nuclear protein SET

    UniProtKB/Swiss-Prot: SET1B_HUMAN, Q9UPS6
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 1 SET domain


    Find genes that share domains with SETD1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SET1B_HUMAN, Q9UPS6
    Function: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1
    histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3
    'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping
    localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic
    control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Numbers (IUBMB): EC 2.1.1.431 2 EC 2.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI17998332
    GO:0018024histone-lysine N-methyltransferase activity ----
         
    Find genes that share ontologies with SETD1B           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SETD1B:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SETD1B
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    miRNA
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    miRTarBase miRNAs that target SETD1B:
    hsa-mir-92a-3p (MIRT049485), hsa-mir-151a-5p (MIRT019516), hsa-mir-25-3p (MIRT050342), hsa-mir-222-3p (MIRT046658), hsa-mir-484 (MIRT042094), hsa-mir-197-3p (MIRT048081), hsa-mir-7-5p (MIRT025865), hsa-mir-27a-3p (MIRT028695), hsa-mir-103a-3p (MIRT027194), hsa-mir-16-5p (MIRT031924)

    Block miRNA regulation of human, mouse, rat SETD1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SETD1B (see all 94):
    hsa-miR-548j hsa-miR-100* hsa-miR-3607-3p hsa-miR-15a hsa-miR-374a hsa-miR-30d hsa-miR-30a hsa-miR-3622b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat SETD1B

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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SETD1B
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SET1B_HUMAN, Q9UPS6: Nucleus speckle. Chromosome. Note=Localizes to a largely non-overlapping set of euchromatic
    nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IEA--
    GO:0035097histone methyltransferase complex IDA17355966

    Find genes that share ontologies with SETD1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SETD1B About    
    See pathways by source

    SuperPathContained pathways About
    1Lysine degradation
    Lysine degradation


    Find genes that share SuperPaths with SETD1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SETD1B):
        Lysine degradation

        Pathway & Disease-focused RT2 Profiler PCR Array including SETD1B: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SETD1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SETD1B (Q9UPS63 ENSP000002671974) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3EP684313, ENSP000003535814I2D: score=1 STRING: ENSP00000353581
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0051568histone H3-K4 methylation IDA17355966

    Find genes that share ontologies with SETD1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SETD1B (SET1B)

    2 HMDB Compounds for SETD1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SETD1B gene: 
    NM_015048.1  

    Unigene Cluster for SETD1B:

    SET domain containing 1B
    Hs.507122  [show with all ESTs]
    Unigene Representative Sequence: NM_015048
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000604567 ENST00000542440(uc021rfg.1) ENST00000267197(uc001ubi.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SETD1B (see all 94):
    hsa-miR-548j hsa-miR-100* hsa-miR-3607-3p hsa-miR-15a hsa-miR-374a hsa-miR-30d hsa-miR-30a hsa-miR-3622b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SETD1B
      QuantiFast Probe-based Assays in human, mouse, rat SETD1B

    Additional mRNA sequence: 

    AB028999.1 AK000810.1 BC047909.1 BC080192.1 JF813787.1 

    7 DOTS entries:

    DT.97762576  DT.121178241  DT.91759659  DT.86851377  DT.121187263  DT.102832698  DT.433511 

    1 AceView cDNA sequence:

    BF195596 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SETD1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGCCTCC
    SETD1B Expression
    About this image

    SETD1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SETD1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507122
        Pathway & Disease-focused RT2 Profiler PCR Array including SETD1B: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SETD1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SETD1B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Setd1b5 SET domain containing 1B   --   5 (62.80 cM) 123142193 
    chicken
    (Gallus gallus)
    Aves SETD1B6
    Gallus gallus SET domain containing 1B (SETD1B), m...
    60(a)
    1 ↔ 1
    15(5634231-5677257)
    lizard
    (Anolis carolinensis)
    Reptilia SETD1B6
    SET domain containing 1B
    58(a)
    1 ↔ 1
    GL343550.1(258329-307066)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.68022 Transcribed sequence with weak similarity to protein more 76.96(n)    BX758753.1 
    zebrafish
    (Danio rerio)
    Actinopterygii setd1ba6
    SET domain containing 1B, a
    51(a)
    1 ↔ 1
    10(43351810-43385465) ENSDARG00000060847
    fruit fly
    (Drosophila melanogaster)
    Insecta Set16
    --
    25(a)
    1 → many
    3LHet(593050-600636)
    worm
    (Caenorhabditis elegans)
    Secernentea set-26
    Protein SET-2, isoform a
    21(a)
    1 → many
    III(4922446-4930204) WBGene00004782
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SET16
    Histone methyltransferase, subunit of the COMPASS ...
    21(a)
    1 → many
    VIII(346043-349285) YHR119W


    ENSEMBL Gene Tree for SETD1B (if available)
    TreeFam Gene Tree for SETD1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SETD1B gene
    KMT2D2  EZH12  KMT2C2  KMT2A2  SETD1A2  EZH22  ENSG000002723332  

    Find genes that share paralogs with SETD1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SETD1B (see all 546)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1463838941,2
    C--122243441(+) GACCCC/GGCAGC 1 -- int10--------
    rs676052541,2
    C--122243596(+) AAAAA-/TTTTTTT 1 -- int11Minor allele frequency- TT:0.00NA 2
    rs30401181,2
    C,F--122243611(+) TTTTT-/T/TT  
            
    AATTT
    1 -- int12NA CSA 4
    rs1839604121,2
    --122243826(+) CCTGAA/GGGACA 2 K R mis10--------
    rs11686661,2
    C,F,A,H--122243905(-) TTGGCA/GATGCC 2 I syn124Minor allele frequency- G:0.29NS EA WA NA CSA 2430
    rs3756659661,2
    C--122244117(+) GGGAT-/CCCCCC 1 -- int10--------
    rs1886857691,2
    --122244124(+) CCCCCC/GCACAA 1 -- int10--------
    rs1397242651,2
    --122244143(+) CTTAGA/CCCCCT 1 -- int10--------
    rs1814652851,2
    --122244270(+) CCCCAC/TCGCTG 1 -- int10--------
    rs1465913661,2
    --122244319(+) GGGTTG/TAGACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SETD1B (122242086 - 122270562 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SETD1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520973CNV Loss19592680
    nsv899566CNV Loss21882294
    nsv911CNV Loss18451855
    nsv899567CNV Gain21882294
    nsv899568CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SETD1B
    DNA2.0 Custom Variant and Variant Library Synthesis for SETD1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611055    OMIM disorders: --


    Find genes that share disorders with SETD1B           About GenesLikeMe


    Export disorders for SETD1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SETD1B gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SETD1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of the human Set1B histone H3- Lys4 methyltransferase complex. (PubMed id 17355966)1, 2, 3 Lee J.-H.... Skalnik D.G. (J. Biol. Chem. 2007)
    2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R.... Ohara O. (DNA Res. 1999)
    3. Rbm15-Mkl1 Interacts with the Setd1b Histone H3-Lys4 Methyltransferase via a SPOC Domain That Is Required for Cytokine- Independent Proliferation. (PubMed id 22927943)1, 2 Lee J.H. and Skalnik D.G. (PLoS ONE 2012)
    4. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. (PubMed id 18838538)1, 2 Wu M....Shilatifard A. (Mol. Cell. Biol. 2008)
    5. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PubMed id 17998332)1, 2 Lee J.H. and Skalnik D.G. (Mol. Cell. Biol. 2008)
    6. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. (PubMed id 24026423)1 Shameer K....Kullo I.J. (Hum. Genet. 2014)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. (PubMed id 22266653)1 Zhang P....Couture J.F. (Nucleic Acids Res. 2012)
    9. Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. (PubMed id 22665483)1 Dharmarajan V....Cosgrove M.S. (J. Biol. Chem. 2012)
    10. A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. (PubMed id 20305087)1 Mak A.B....Moffat J. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23067 HGNC: 29187 AceView: KIAA1076.3 Ensembl:ENSG00000139718 euGenes: HUgn23067
    ECgene: SETD1B Kegg: 23067 H-InvDB: SETD1B

    (According to HUGE)
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    HUGE: KIAA1076

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SETD1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SETD1B gene:
    Search GeneIP for patents involving SETD1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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