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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SETD1B Gene

protein-coding   GIFtS: 50
GCID: GC12P122243

SET domain containing 1B
 Explore 2 diseases affiliated with
SETD1B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SETD1B    

Aliases
for SETD1B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SET Domain Containing 1B1 2     SET Domain-Containing Protein 1B2 3
KMT2G1 2 3     EC 2.1.1.433 8
KIAA10761 3 5     SET1B3 5
Set1B1 2     Histone-Lysine N-Methyltransferase SETD1B2
Lysine N-Methyltransferase 2G2 3     EC 2.1.18
HSET1B1     

External Ids:    HGNC: 291871   Entrez Gene: 230672   Ensembl: ENSG000001397187   OMIM: 6110555   UniProtKB: Q9UPS63   

Export aliases for SETD1B gene to outside databases

Previous GC identifers: GC12P120726 GC12P119254


Summaries
for SETD1B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SETD1B:
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al.,
2007 (PubMed 17355966)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SET1B_HUMAN, Q9UPS6
Function: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone
methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4'
methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with
SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin
structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro




Genomic Views
for SETD1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SETD1B gene promoter:
         AhR   USF1   MyoD   Olf-1   Lmo2   Ik-3   AREB6   HOXA5   USF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SETD1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SETD1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

SETD1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETD1B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P122243:  view genomic region     (about GC identifiers)

Start:
 122,242,086 bp from pter      End:
 122,270,562 bp from pter
Size:
 28,477 bases      Orientation:
 plus strand

Proteins
for SETD1B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SET1B_HUMAN, Q9UPS6 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SETD1B  
Size: 1923 amino acids; 208732 Da
Subunit: Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82,
RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with HCFC1 and ASH2L/ASH2. Interacts (via the RRM domain)
with WDR82. Interacts (via the RRM domain) with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large
subunit (POLR2A) only in the presence of WDR82. Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of
each heptad
Subcellular location: Nucleus speckle. Chromosome. Note=Localizes to a largely non-overlapping set of euchromatic
nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes
2 PDB 3D structures from and Proteopedia for SETD1B:
3UVO (3D)        4ES0 (3D)    

Explore the universe of human proteins at neXtProt for SETD1B: NX_Q9UPS6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UPS6

    • 4/26 DME Specific Peptides for SETD1B (Q9UPS6) (see all 26)
     FDEWWDK  ISSSSSQ  TGCARSE  KLYRYDG 

    SETD1B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055863.1  
    ENSEMBL proteins: 
     ENSP00000442924   ENSP00000267197  

    Human Recombinant Protein Products: 
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    Uscn Proteins for SETD1B

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IEA--
    GO:0035097histone methyltransferase complex IDA17355966


    SETD1B for ontologies           About GeneDecksing



    SETD1B Antibody Products: 
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    Uscn Antibodies for SETD1B
    Search ThermoFisher Antibodies for SETD1B

    Assay Products for SETD1B: 
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    Uscn ELISAs and CLIAs for SETD1B

    Protein Domains /
    Families
    for SETD1B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SETD1B for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001214 SET_dom
     IPR003616 Post-SET_dom
     IPR024657 COMPASS_Set1_N-SET
     IPR015722 Histone-lysine_MeTfrase
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9UPS6

    ProtoNet protein and cluster: Q9UPS6

    1 Blocks protein family: IPB001214 Nuclear protein SET

    UniProtKB/Swiss-Prot: SET1B_HUMAN, Q9UPS6
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 1 SET domain


    Function
    for SETD1B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SET1B_HUMAN, Q9UPS6
    Function: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone
    methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4'
    methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with
    SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin
    structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

    Enzyme Numbers (IUBMB): EC 2.1.1.431 2 EC 2.1.12

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SETD1B
    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate SETD1B (see all 94):
    hsa-miR-548j hsa-miR-100* hsa-miR-3607-3p hsa-miR-15a hsa-miR-374a hsa-miR-30d hsa-miR-30a hsa-miR-3622b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SETD1B (see all 4)
    OriGene shRNA RFP: SETD1B
    OriGene siRNA: SETD1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SETD1B

    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI17998332
    GO:0042800contributes to histone methyltransferase activity (H3-K4 specific) IDA17355966


    SETD1B for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for SETD1B:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 


    Pathways & Interactions
    for SETD1B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lysine degradation
    		Lysine degradation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for SETD1B):
        Lysine degradation


    SETD1B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SETD1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/25 Interacting proteins for SETD1B (Q9UPS63 ENSP000002671974) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3EP684313, ENSP000003535814I2D: score=1 STRING: ENSP00000353581
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0051568histone H3-K4 methylation IDA17355966


    SETD1B for ontologies           About GeneDecksing



    Drugs & Compounds
    for SETD1B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SETD1B

    2 HMDB Compounds for SETD1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Search CenterWatch for drugs/clinical trials and news about SETD1B / SET1B 

    Transcripts
    for SETD1B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SETD1B gene: 
    NM_015048.1  

    Unigene Cluster for SETD1B:

    SET domain containing 1B
    Hs.507122  [show with all ESTs]
    Unigene Representative Sequence: NM_015048
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000542440(uc021rfg.1) ENST00000267197(uc001ubi.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SETD1B
    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate SETD1B (see all 94):
    hsa-miR-548j hsa-miR-100* hsa-miR-3607-3p hsa-miR-15a hsa-miR-374a hsa-miR-30d hsa-miR-30a hsa-miR-3622b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SETD1B (see all 4)
    OriGene shRNA RFP: SETD1B
    OriGene siRNA: SETD1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SETD1B
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SETD1B (see all 2)
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    GenScript: all cDNA clones in your preferred vector: SETD1B (NM_015048)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SETD1B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SETD1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SETD1B

    Additional cDNA sequence: 

    AB028999.1 AK000810.1 BC047909.1 BC080192.1 JF813787.1 

    7 DOTS entries:

    DT.97762576  DT.121178241  DT.91759659  DT.86851377  DT.121187263  DT.102832698  DT.433511 

    1 AceView cDNA sequence:

    BF195596 

    GeneLoc Exon Structure


    Expression
    for SETD1B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SETD1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACAGCCTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SETD1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SETD1B

    SOURCE GeneReport for Unigene cluster: Hs.507122
        SABiosciences Expression via Pathway-Focused PCR Array including SETD1B: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for SETD1B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SETD1B gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SETD1B1 SET domain containing 1B 66.41(n)
    68.61(a)    		   416851  NM_001030661.1  NP_001025832.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SETD1B6
    		 --
    		 57(a)
    		 1 ↔ 1
    		 GL343550.1(264690-307066)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.68022 Transcribed sequence with weak similarity to protein more 76.96(n)    BX758753.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii setd1ba1 SET domain containing 1B, a 60.16(n)
    56.86(a)    		   567970  NM_001045134.2  NP_001038599.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Set16
    		 --
    		 23(a)
    		 1 → many
    		 3LHet(593050-600636)
    worm
    (Caenorhabditis elegans)    		 Secernentea set-26
    		 Probable histone-lysine N-methyltransferase set-2
    		 18(a)
    		 1 → many
    		 III(4922835-4930170)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATX26
    SDG276
    (see all 3)    		 histone-lysine N-methyltransferase ATX1
    (see all 3)    		 9(a)
    9(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 1(1754244-1761817)
    2(13455272-13462181)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 SET domain containing protein, expressed
    (see all 3)    		 9(a)
    14(a)
    (see all 3)    		 possible ortholog
    1 ↔ many
    (see all 3)    		 9(2600650-2614934)
    12(25933830-25942444)


    ENSEMBL Gene Tree for SETD1B (if available)
    TreeFam Gene Tree for SETD1B (if available) 

    Paralogs
    for SETD1B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SETD1B gene
    MLL22  MLL42  MLL2  MLL32  SETD1A2  
    1 SIMAP similar gene for SETD1B using alignment to 2 protein entries:     SET1B_HUMAN (see all proteins):
    DKFZp686C08112

    SETD1B for paralogs           About GeneDecksing



    Genomic Variants
    for SETD1B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/411 NCBI SNPs in SETD1B are shown (see all 411)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1161017501,2
    		--122240864(+) GTTTTG/CAGATC 2 -- nc-transcript-variantus2k11Minor allele frequency- C:0.01WA 118
    rs1444481421,2
    		--122240958(+) CCACGA/GCCAAA 2 -- nc-transcript-variantus2k10--------
    rs125783401,2
    		H--122240959(+) CACGGC/GCAAAT 2 -- us2k1 nc-transcript-variant0--------
    rs1174888741,2
    		F,--122241003(+) CACCAG/ACTCCG 2 -- nc-transcript-variantus2k11Minor allele frequency- A:0.03EA 120
    rs1483911321,2
    		--122241041(+) CGGCCG/TCCAGA 2 -- nc-transcript-variantus2k10--------
    rs793458021,2
    		--122241506(+) CTCGGG/CCCCCC 2 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1928123021,2
    		--122242911(+) CGGCCA/CACTGT 2 -- int1 us2k10--------
    rs734137491,2
    		C,--122242969(+) GTCTGC/TCCATG 2 -- us2k1 int11Minor allele frequency- T:0.50WA 2
    rs1415891381,2
    		--122243167(+) CTCCCC/TGAGTT 2 -- int1 us2k10--------
    rs1463838941,2
    		--122243441(+) GACCCC/GGCAGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SETD1B (122242086 - 122270562 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SETD1B
         2 CNVs: 76169 48966

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    Disorders / Diseases
    for SETD1B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SETD1B for disorders           About GeneDecksing

    OMIM gene information: 611055    OMIM disorders: --

    2 diseases for SETD1B:    About MalaCards
    homocysteine    leukemia


    Export disorders for SETD1B gene to outside databases

    Publications
    for SETD1B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SETD1B gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SETD1B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of the human Set1B histone H3- Lys4 methyltransferase complex. (PubMed id 17355966)1, 2, 3 Lee J.-H.... Skalnik D.G. (2007)
    2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
    3. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. (PubMed id 18838538)1, 2 Wu M....Shilatifard A. (2008)
    4. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PubMed id 17998332)1, 2 Lee J.H. and Skalnik D.G. (2008)
    5. Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 m ethyltransferase via a SPOC domain that is required for cytokine-independent pro liferation. (PubMed id 22927943)1 Lee J.H. and Skalnik D.G. (2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. The plasticity of WDR5 peptide-binding cleft enables t he binding of the SET1 family of histone methyltransferases. (PubMed id 22266653)1 Zhang P....Couture J.F. (2012)
    8. Structural basis for WDR5 interaction (Win) motif reco gnition in human SET1 family histone methyltransferases. (PubMed id 22665483)1 Dharmarajan V....Cosgrove M.S. (2012)
    9. A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. (PubMed id 20305087)1 Mak A.B....Moffat J. (2010)
    10. Identification and characterization of a novel human PP1 phosphatase complex. (PubMed id 20516061)1 Lee J.H....Skalnik D.G. (2010)

    External Searches for SETD1B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    Genome Databases showing SETD1B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23067 HGNC: 29187 AceView: KIAA1076.3 Ensembl:ENSG00000139718 euGenes: HUgn23067
    ECgene: SETD1B Kegg: 23067 H-InvDB: SETD1B

    Other Databases showing SETD1B gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1076

    Specialized Databases showing SETD1B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SETD1B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SETD1B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SETD1B gene:
    Search GeneIP for patents involving SETD1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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