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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SETD1A Gene

protein-coding   GIFtS: 56
GCID: GC16P030968

SET domain containing 1A
 Explore 5 diseases affiliated with
SETD1A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SETD1A    

Aliases
for SETD1A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SET Domain Containing 1A1 2     SET Domain-Containing Protein 1A2 3
KMT2F1 2 3     EC 2.1.1.433 8
KIAA03391 3 5     SET13 5
Set11 2     SET1A3 5
Lysine N-Methyltransferase 2F2 3     Set1A2
Set1/Ash2 Histone Methyltransferase Complex Subunit SET12 3     Histone-Lysine N-Methyltransferase SETD1A2
HSET1A1     

External Ids:    HGNC: 290101   Entrez Gene: 97392   Ensembl: ENSG000000993817   OMIM: 6110525   UniProtKB: O150473   

Export aliases for SETD1A gene to outside databases

Previous GC identifers: GC16P030877 GC16P030878 GC16P028531


Summaries
for SETD1A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SETD1A:
SET1A is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone
H3 at Lys4. The complex is the analog of the S. cerevisiae Set1/COMPASS complex (Lee and Skalnik, 2005 (PubMed
16253997)). Also see SET1B (MIM 611055).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SET1A_HUMAN, O15047
Function: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone
methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4'
methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with
SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin
structure and gene expression




Genomic Views
for SETD1A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SETD1A gene promoter:
         E2F-4   E2F-3a   E2F-5   HTF   CUTL1   E2F-2   MZF-1   E2F   E2F-1   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SETD1A promoter sequence
   Search SABiosciences Chromatin IP Primers for SETD1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SETD1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SETD1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SETD1A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P030968:  view genomic region     (about GC identifiers)

Start:
 30,968,615 bp from pter      End:
 30,996,437 bp from pter
Size:
 27,823 bases      Orientation:
 plus strand

Proteins
for SETD1A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SET1A_HUMAN, O15047 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SETD1A  
Size: 1707 amino acids; 186034 Da
Subunit: Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82,
RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with HCFC1. Interacts with ASH2/ASH2L, CXXC1/CFP1, WDR5 and
RBBP5. Interacts (via the RRM domain) with WDR82. Interacts (via the RRM domain) with hyperphosphorylated C-terminal
domain (CTD) of RNA polymerase II large subunit (POLR2A) only in the presence of WDR82. Binds specifically to CTD
heptad repeats phosphorylated on 'Ser-5' of each heptad
Subcellular location: Nucleus speckle. Chromosome. Note=Localizes to a largely non-overlapping set of euchromatic
nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes
Sequence caution: Sequence=AAH35795.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence; Sequence=BAA20797.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for SETD1A:
3S8S (3D)        3UVN (3D)        4EWR (3D)    
Secondary accessions: A6NP62 Q6PIF3 Q8TAJ6

Explore the universe of human proteins at neXtProt for SETD1A: NX_O15047

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15047

    • 4/10 DME Specific Peptides for SETD1A (O15047) (see all 10)
     IGSSYLF  CGTESCR  PNCYAKV  ARFINHCC 

    SETD1A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055527.1  
    ENSEMBL proteins: 
     ENSP00000262519   ENSP00000391408  

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    OriGene Protein Over-expression Lysate: SETD1A
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    Uscn Proteins for SETD1A

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IEA--
    GO:0035097histone methyltransferase complex IDA17500065


    SETD1A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SETD1A

    Protein Domains /
    Families
    for SETD1A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SETD1A for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001214 SET_dom
     IPR003616 Post-SET_dom
     IPR024657 COMPASS_Set1_N-SET
     IPR015722 Histone-lysine_MeTfrase
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O15047

    ProtoNet protein and cluster: O15047

    2 Blocks protein families:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001214 Nuclear protein SET


    UniProtKB/Swiss-Prot: SET1A_HUMAN, O15047
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 1 SET domain


    Function
    for SETD1A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SET1A_HUMAN, O15047
    Function: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone
    methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4'
    methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with
    SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin
    structure and gene expression
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

    Enzyme Number (IUBMB): EC 2.1.1.431 2

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate SETD1A (see all 28):
    hsa-miR-142-5p hsa-miR-1914* hsa-let-7a-2* hsa-miR-340 hsa-miR-3692 hsa-miR-23b* hsa-let-7g* hsa-miR-34b
    SwitchGear 3'UTR luciferase reporter plasmid: SETD1A 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SETD1A

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI12670868
    GO:0042800histone methyltransferase activity (H3-K4 specific) IDA--


    SETD1A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SETD1A:
     Increased G1 DNA content 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Setd1a):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     skeleton 

    SETD1A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SETD1A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lysine degradation
    		Lysine degradation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for SETD1A):
        Lysine degradation


    SETD1A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SETD1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/23 Interacting proteins for SETD1A (O150471, 3 ENSP000002625194) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCFC1P516101, 3, ENSP000003095554EBI-540779,EBI-2832627 I2D: score=3 STRING: ENSP00000309555
    ASH2LQ9UBL33, ENSP000003408964I2D: score=1 STRING: ENSP00000340896
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    CXXC1Q9P0U43, ENSP000003904754I2D: score=1 STRING: ENSP00000390475
    MYBP102423, ENSP000003399924I2D: score=1 STRING: ENSP00000339992
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0051568histone H3-K4 methylation IDA--


    SETD1A for ontologies           About GeneDecksing



    Drugs & Compounds
    for SETD1A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SETD1A

    2 HMDB Compounds for SETD1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Search CenterWatch for drugs/clinical trials and news about SETD1A / SET1A 

    Transcripts
    for SETD1A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SETD1A gene: 
    NM_014712.1  

    Unigene Cluster for SETD1A:

    SET domain containing 1A
    Hs.297483  [show with all ESTs]
    Unigene Representative Sequence: NM_014712
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262519(uc002eae.1 uc002ead.1) ENST00000452917

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate SETD1A (see all 28):
    hsa-miR-142-5p hsa-miR-1914* hsa-let-7a-2* hsa-miR-340 hsa-miR-3692 hsa-miR-23b* hsa-let-7g* hsa-miR-34b
    SwitchGear 3'UTR luciferase reporter plasmid: SETD1A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SETD1A (see all 4)
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SETD1A
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    Additional cDNA sequence: 

    AB002337.2 BC027450.1 BC035795.2 

    6 DOTS entries:

    DT.95162069  DT.97843351  DT.95273550  DT.91762705  DT.95094180  DT.100048179 

    24/125 AceView cDNA sequences (see all 125):

    BM973083 CD360042 BQ923219 BG912869 AB002337 BE727774 BG752701 AL044881 
    BF591347 BU181062 BQ420749 BE302430 CK429872 AA860173 BE743024 AI206377 
    BE207359 BU944676 BQ073607 AI860292 CK430507 BM679865 BU845167 BM725789 

    GeneLoc Exon Structure


    Expression
    for SETD1A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SETD1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCTCCCCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SETD1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SETD1A

    SOURCE GeneReport for Unigene cluster: Hs.297483
        SABiosciences Expression via Pathway-Focused PCR Array including SETD1A: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    In Situ
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    Orthologs
    for SETD1A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SETD1A gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia SETD1A6
    		 --
    		 53(a)
    		 1 ↔ 1
    		 GL343220.1(1879858-1900385)
    zebrafish
    (Danio rerio)    		 Actinopterygii setd1a1 SET domain containing 1A 55.23(n)
    50.56(a)    		   556535  XM_001920817.3  XP_001920852.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Set16
    		 --
    		 21(a)
    		 1 → many
    		 3LHet(593050-600636)
    worm
    (Caenorhabditis elegans)    		 Secernentea set-26
    		 Probable histone-lysine N-methyltransferase set-2
    		 19(a)
    		 1 → many
    		 III(4922835-4930170)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATX26
    SDG276
    (see all 3)    		 histone-lysine N-methyltransferase ATX1
    (see all 3)    		 8(a)
    8(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 1(1754244-1761817)
    2(13455272-13462181)
    rice
    (Oryza sativa)    		 Liliopsida Os.88202 Oryza sativa (japonica cultivar-group) cDNA cloneJ023073B16, full insert sequence less 68.69(n)    AK068250.1 


    ENSEMBL Gene Tree for SETD1A (if available)
    TreeFam Gene Tree for SETD1A (if available) 

    Paralogs
    for SETD1A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SETD1A gene
    MLL22  MLL42  MLL2  SETD1B2  MLL32  
    1 SIMAP similar gene for SETD1A using alignment to 3 protein entries:     SET1A_HUMAN (see all proteins):
    DKFZp686C08112

    SETD1A for paralogs           About GeneDecksing



    Genomic Variants
    for SETD1A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/544 NCBI SNPs in SETD1A are shown (see all 544)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs766173951,2
    		C,F,--28557114(+) TCCGGG/AACCCC 3 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1121125031,2
    		F,--28557206(+) TAGAAC/TGGCCA 3 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs755863651,2
    		C,--28558819(+) TCAGCC/TCACTC 3 -- us2k12Minor allele frequency- T:0.09NA 122
    rs1884931381,2
    		--30966901(+) CGGCTA/CACTGC 1 -- us2k10--------
    rs1921561401,2
    		--30966911(+) CAAGCA/GCCGCC 1 -- us2k10--------
    rs1847860491,2
    		--30966968(+) GATTAC/TAGGTG 1 -- us2k10--------
    rs1895246091,2
    		--30966986(+) CCACGA/CTCGGC 1 -- us2k10--------
    rs1808028651,2
    		--30967032(+) TTCACC/TGTGTT 1 -- us2k10--------
    rs1137359521,2
    		C,--30967210(+) GGCTCG/ATGAGC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs2005314241,2
    		--30967271(+) CCAGC-/TAAT  
                TAATT     		1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SETD1A (30968615 - 30996437 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SETD1A
         3 CNVs: 4942 4941 7104

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    Disorders / Diseases
    for SETD1A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SETD1A for disorders           About GeneDecksing

    OMIM gene information: 611052    OMIM disorders: --

    5 diseases for SETD1A:    About MalaCards
    anus neoplasm    hemometra    herpes simplex    homocysteine
    leukemia

    1 disease from the University of Copenhagen DISEASES database for SETD1A:
    Hemometra
    Human Genome Epidemiology (HuGE) Navigator: SETD1A (1 document)

    Export disorders for SETD1A gene to outside databases

    Publications
    for SETD1A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SETD1A gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with SETD1A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1. (PubMed id 12670868)1, 2, 3 Wysocka J.... Herr W. (2003)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    3. CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. (PubMed id 16253997)1, 2, 9 Lee J.-H. and Skalnik D.G. (2005)
    4. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PubMed id 17998332)1, 2 Lee J.H. and Skalnik D.G. (2008)
    5. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. (PubMed id 18838538)1, 2 Wu M....Shilatifard A. (2008)
    6. Identification and characterization of the human Set1B histone H3- Lys4 methyltransferase complex. (PubMed id 17355966)1, 2 Lee J.-H.... Skalnik D.G. (2007)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Structural basis for WDR5 interaction (Win) motif reco gnition in human SET1 family histone methyltransferases. (PubMed id 22665483)1 Dharmarajan V....Cosgrove M.S. (2012)

    External Searches for SETD1A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    Genome Databases showing SETD1A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9739 HGNC: 29010 AceView: KIAA0339 Ensembl:ENSG00000099381 euGenes: HUgn9739
    ECgene: SETD1A Kegg: 9739 H-InvDB: SETD1A

    Other Databases showing SETD1A gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0339

    Specialized Databases showing SETD1A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SETD1A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SETD1A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SETD1A gene:
    Search GeneIP for patents involving SETD1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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