Aliases for SETD1A Gene
External Ids for SETD1A Gene
The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Jan 2015]
GeneCards Summary for SETD1A Gene
SETD1A (SET Domain Containing 1A) is a Protein Coding gene. Diseases associated with SETD1A include hemometra. Among its related pathways are Lysine degradation. GO annotations related to this gene include RNA binding and histone methyltransferase activity (H3-K4 specific). An important paralog of this gene is KMT2C.
UniProtKB/Swiss-Prot for SETD1A Gene
Histone methyltransferase that specifically methylates Lys-4 of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring Lys-9 residue is already methylated. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.