Aliases for SETD1A Gene
External Ids for SETD1A Gene
Previous GeneCards Identifiers for SETD1A Gene
The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Dec 2016]
GeneCards Summary for SETD1A Gene
SETD1A (SET Domain Containing 1A) is a Protein Coding gene. Diseases associated with SETD1A include Schizophrenia and Cerebritis. Among its related pathways are Chromatin organization and PKMTs methylate histone lysines. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SETD1B.
UniProtKB/Swiss-Prot for SETD1A Gene
Histone methyltransferase that specifically methylates Lys-4 of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring Lys-9 residue is already methylated. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.