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SET Gene

protein-coding   GIFtS: 68
GCID: GC09P131445

SET Nuclear Oncogene

(Previous name: SET translocation (myeloid leukemia-associated))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SET Nuclear Oncogene1 2     Template-Activating Factor-I1
SET Translocation (Myeloid Leukemia-Associated)1 2     2PP2A2
Protein Phosphatase Type 2A Inhibitor1 2     I2PP2A2
Inhibitor Of Granzyme A-Activated DNase2 3     IPP2A22
Phosphatase 2A Inhibitor I2PP2A2 3     TAF-IBETA2
IGAAD2 3     Inhibitor-2 Of Protein Phosphatase-2A2
PHAPII2 3     Protein SET2
TAF-I2 3     Template-Activating Factor-I, Chromatin Remodelling Factor2
HLA-DR-Associated Protein II2 3     I-2PP2A3
Chromatin Remodelling Factor1     Template-Activating Factor I3

External Ids:    HGNC: 107601   Entrez Gene: 64182   Ensembl: ENSG000001193357   OMIM: 6009605   UniProtKB: Q011053   

Export aliases for SET gene to outside databases

Previous GC identifers: GC09P122566 GC09P123092 GC09P124900 GC09P126822 GC09P128525 GC09P130485 GC09P101055


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SET Gene:
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases
(HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the
consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the
endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T
lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for SET Gene:
SET (SET nuclear oncogene) is a protein-coding gene. GO annotations related to this gene include histone binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is TSPY6P.

UniProtKB/Swiss-Prot: SET_HUMAN, Q01105
Function: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning.
Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of
cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing
NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2
inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking
the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4.
HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both
isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform
2 specific activity is higher

Gene Wiki entry for SET (Protein SET) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SET gene promoter:
         Max   AP-1   ATF-2   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSET promoter sequence
   Search Chromatin IP Primers for SET

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SET


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34

SET Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SET gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P131445:  view genomic region     (about GC identifiers)

Start:
131,445,703 bp from pter      End:
131,458,679 bp from pter
Size:
12,977 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SET_HUMAN, Q01105 (See protein sequence)
Recommended Name: Protein SET  
Size: 290 amino acids; 33489 Da
Subunit: Interacts with CHTOP (By similarity). Headphone-shaped homodimer. Isoform 1 and isoform 2 interact
directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex.
Isoform 1 and isoform 2 interact also with histones. Isoform 2 is a component of the SET complex, which also
contains ANP32A, APEX1, HMGB2 and NME1, but not NME2. Within this complex, directly interacts with NME1 and with
HMGB2. Interacts with SETBP1. Interacts with SGOL1. Interacts with APBB1
1 PDB 3D structure from and Proteopedia for SET:
2E50 (3D)    
Secondary accessions: A5A5H4 A6NGV1 B4DUE2 Q15541 Q5VXV1 Q5VXV2 Q6FHZ5
Alternative splicing: 4 isoforms:  Q01105-1   Q01105-2   Q01105-3   Q01105-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for SET: NX_Q01105

Explore proteomics data for SET at MOPED

Post-translational modifications: 

  • Isoform 2 is phosphorylated on Ser-15 and Thr-231
  • Isoform 2 is acetylated on Lys-111
  • Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and
    results in a glycine chain on the gamma-carboxyl group (By similarity)1
  • N-terminus of isoform 1 is methylated by METTL11A/NTM1. Mainly trimethylated (By similarity)1
  • Ubiquitination2 at Lys83, Lys132, Lys150, Lys154, Lys167, Lys172
  • Modification sites at PhosphoSitePlus

  • See SET Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001116293.1  NP_001234929.1  NP_001234930.1  NP_003002.2  

    ENSEMBL proteins: 
     ENSP00000410806   ENSP00000361777   ENSP00000387321   ENSP00000318012   ENSP00000361771  
     ENSP00000361773  
    Reactome Protein details: Q01105

    SET Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for SET
    Novus Biologicals SET Proteins
    Novus Biologicals SET Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SET
    Cloud-Clone Corp. Proteins for SET

     
    Search eBioscience for Proteins for SET 

     
    antibodies-online proteins for SET (2 products) 

     
    antibodies-online peptides for SET

    SET Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for SET
    Cloud-Clone Corp. Antibodies for SET
    ThermoFisher Antibody for SET
    antibodies-online antibodies for SET (60 products) 

    SET Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SET
    Cloud-Clone Corp. CLIAs for SET
    Search eBioscience for ELISAs for SET 
    antibodies-online kits for SET (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002164 NAP_family

    Graphical View of Domain Structure for InterPro Entry Q01105

    ProtoNet protein and cluster: Q01105

    1 Blocks protein domain: IPB002164 Nucleosome assembly protein (NAP)

    UniProtKB/Swiss-Prot: SET_HUMAN, Q01105
    Domain: A long alpha helix in the N-terminus mediates dimerization, while the earmuff domain is responsible for
    core histone and dsDNA binding. The C-terminal acidic domain mediates the inhibition of histone
    acetyltransferases and is required for the DNA replication stimulatory activity
    Similarity: Belongs to the nucleosome assembly protein (NAP) family


    Find genes that share domains with SET           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SET_HUMAN, Q01105
    Function: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning.
    Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of
    cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing
    NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2
    inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking
    the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4.
    HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both
    isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform
    2 specific activity is higher

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004864protein phosphatase inhibitor activity TAS8626647
    GO:0005515protein binding IPI11909973
    GO:0008601protein phosphatase type 2A regulator activity TAS11555662
    GO:0042393histone binding TAS11555662
         
    Find genes that share ontologies with SET           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SET

    miRNA
    Products:
        
    miRTarBase miRNAs that target SET:
    hsa-mir-100-5p (MIRT048527), hsa-mir-26a-5p (MIRT050146), hsa-mir-199b-5p (MIRT001112), hsa-mir-18a-3p (MIRT040796), hsa-mir-1260b (MIRT052765), hsa-mir-484 (MIRT041853), hsa-mir-423-3p (MIRT042555), hsa-mir-93-5p (MIRT048741), hsa-mir-375 (MIRT019832), hsa-mir-505-5p (MIRT037978), hsa-mir-296-3p (MIRT038454), hsa-mir-185-5p (MIRT045377), hsa-mir-122-5p (MIRT023293), hsa-mir-378a-5p (MIRT044003), hsa-mir-877-3p (MIRT036919)

    Block miRNA regulation of human, mouse, rat SET using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SET (see all 40):
    hsa-miR-411 hsa-miR-128 hsa-let-7a-2* hsa-miR-371-5p hsa-miR-3921 hsa-miR-3171 hsa-miR-502-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSET 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SET

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SET

    Clone
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    OriGene ORF clones in mouse, rat for SET
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SET (NM_003011)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SET
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SET
    Addgene plasmids for SET 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SET 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SET


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SET_HUMAN, Q01105: Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. Note=In the cytoplasm,
    found both in the cytosol and associated with the endoplasmic reticulum. Following CTL attack, moves rapidly to
    the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus
    is also observed for lymphocyte-activated killer cells after the addition of calcium. The SET complex is
    associated with the endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    nucleus5
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11555662
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA11909973
    GO:0005783endoplasmic reticulum IDA11555662
    GO:0005829cytosol IEA--

    Find genes that share ontologies with SET           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SET About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2RNA Polymerase I Promoter Opening
    Condensation of Prophase Chromosomes0.78
    Mitotic Prophase0.56
    3CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
    Stabilization of mRNA by HuR0.00
    4Gene Expression
    Gene Expression0.40
    5Activation of DNA fragmentation factor
    Granzyme-A Pathway0.32


    Find genes that share SuperPaths with SET           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SET
        Granzyme-A Pathway
    Transcriptional Regulatory Network in Embryonic Stem Cell
    Granzyme Pathway

    2 Reactome Pathways for SET
        Condensation of Prophase Chromosomes
    HuR stabilizes mRNA


        Pathway & Disease-focused RT2 Profiler PCR Array including SET: 
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SET

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SET (Q011051, 2, 3 ENSP000003617774) via UniProtKB, MINT, STRING, and/or I2D (see all 224)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST4H4P628053, ENSP000003507674I2D: score=2 STRING: ENSP00000350767
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS7753797
    GO:0006334nucleosome assembly IEA--
    GO:0006337nucleosome disassembly TAS11555662
    GO:0006913nucleocytoplasmic transport NAS11555662

    Find genes that share ontologies with SET           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SET

    1 HMDB Compound for SET    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 Novoseek inferred chemical compound relationships for SET gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 34.5 4 17374386 (1), 17512990 (1), 12540855 (1), 15869391 (1)
    serine 30.5 3 8131851 (1), 9773788 (1), 12615323 (1)
    threonine 6.48 2 9773788 (1), 12615323 (1)
    estrogen 0 4 12511607 (3)



    Find genes that share compounds with SET           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SET gene (4 alternative transcripts): 
    NM_001122821.1  NM_001248000.1  NM_001248001.1  NM_003011.3  

    Unigene Cluster for SET:

    SET nuclear oncogene
    Hs.436687  [show with all ESTs]
    Unigene Representative Sequence: NM_003011
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454747 ENST00000372692(uc004bvt.4 uc022bol.1 uc011mbj.2)
    ENST00000409104 ENST00000322030(uc004bvu.4) ENST00000372686 ENST00000466009
    ENST00000477806 ENST00000480217 ENST00000480536 ENST00000485056 ENST00000372688

    miRNA
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    Block miRNA regulation of human, mouse, rat SET using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SET (see all 40):
    hsa-miR-411 hsa-miR-128 hsa-let-7a-2* hsa-miR-371-5p hsa-miR-3921 hsa-miR-3171 hsa-miR-502-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSET 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SET
    Clone
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    OriGene ORF clones in mouse, rat for SET
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SET (NM_003011)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SET
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SET
    Addgene plasmids for SET 
    Primer
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    OriGene qPCR primer pairs and template standards for SET
    OriGene qSTAR qPCR primer pairs in human, mouse for SET
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SET
      QuantiTect SYBR Green Assays in human, mouse, rat SET
      QuantiFast Probe-based Assays in human, mouse, rat SET

    Additional mRNA sequence: 

    AK223556.1 AK300609.1 AK300794.1 AK311346.1 AK315313.1 AY349172.1 BC014567.2 BC032749.1 
    BC056245.1 CR536543.1 CR542050.1 D45198.1 EF534308.1 JF729356.1 M93651.1 U51924.1 
    X75091.1 Y16698.1 Y16700.1 Y16709.1 

    Selected DOTS entries (see all 52):

    DT.455509  DT.100684565  DT.91848738  DT.97862088  DT.91782138  DT.100684573  DT.91782177  DT.100684566 
    DT.99929024  DT.100684562  DT.91782179  DT.100059799  DT.91717929  DT.97862793  DT.100684563  DT.100684575 
    DT.91962483  DT.102842660  DT.100684561  DT.102838783  DT.91782197  DT.100749036  DT.121201580  DT.121201495 

    Selected AceView cDNA sequences (see all 1177):

    BE046796 BU631610 W25683 AA477960 T64740 CB115277 BQ774097 BQ674715 
    AI580115 AA460676 BU619135 CA418376 N41803 AI968676 BU153603 CA392110 
    AA634910 CB133792 CB112493 AI123422 BX094596 BM915046 BQ957528 AA564466 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SET (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
    SP1:        -     -     -     -     -     -                       -                                             
    SP2:              -     -     -     -     -                       -                                             
    SP3:                    -     -     -     -                       -                                             
    SP4:                          -     -     -                       -                                             
    SP5:                                      -                       -                                             


    ECgene alternative splicing isoforms for SET

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SET expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTGTCTA
    SET Expression
    About this image


    SET expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    SET Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SET Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436687

    UniProtKB/Swiss-Prot: SET_HUMAN, Q01105
    Tissue specificity: Widely expressed. Low levels in quiescent cells during serum starvation, contact inhibition or
    differentiation. Highly expressed in Wilms' tumor

        Pathway & Disease-focused RT2 Profiler PCR Array including SET: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SET gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Set1 , 5 SET nuclear oncogene1, 5 93.81(n)1
    98.42(a)1
      2 (21.09 cM)5
    560861  NM_023871.41  NP_076360.11 
     300573785 
    chicken
    (Gallus gallus)
    Aves SET1 SET nuclear oncogene 90.97(n)
    100(a)
      417210  NM_001030691.2  NP_001025862.2 
    lizard
    (Anolis carolinensis)
    Reptilia SET6
    SET nuclear oncogene
    74(a)
    1 ↔ 1
    AAWZ02037496(1699-2802)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056839.12   -- 82.07(n)    BC056839.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.282392 Danio rerio clone RK071A2C04 myeloid leukemia-associated more 77.72(n)    AY398416.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Set1 , 3 cyclin binding3
    Set1
    65(a)3
    60.8(n)1
    63.43(a)1
      88E83
    418441  NM_142181.31  NP_650438.21 
    worm
    (Caenorhabditis elegans)
    Secernentea spr-21 , 3 SET protein3
    spr-21
    39(a)3
    52.72(n)1
    44.57(a)1
      IV(8891548-8892716)3
    1777041  NM_001026162.41  NP_001021333.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NRP11 NRP1 56.91(n)
    45.74(a)
      843797  NM_001036205.2  NP_001031282.1 
    rice
    (Oryza sativa)
    Liliopsida AK109192.12   -- 70.57(n)    AK109192.1 


    ENSEMBL Gene Tree for SET (if available)
    TreeFam Gene Tree for SET (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SET gene
    TSPY6P2  TSPYL12  TSPYL62  TSPY42  TSPY12  TSPY82  TSPYL22  TSPYL52  
    TSPYL42  TSPY102  TSPY22  TSPY32  
    12 SIMAP similar genes for SET using alignment to 3 protein entries:     SET_HUMAN (see all proteins):
    TSPY26P    TSPYL4    LOC728395    TSPYL    TSPYL5    TSPY10
    TSPY2    TSPY4    TSPY8    TSPY1    TSPY3    TSPY6P

    Find genes that share paralogs with SET           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for SET (see all 21)
    PGOHUM00000242502 PGOHUM00000242834 PGOHUM00000239917 PGOHUM00000247729 PGOHUM00000248167


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SET (see all 315)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460673281,2
    C--101059816(+) CTCCC-/GCCTG 
    TAATCCCA
    GCACT
    1 -- int10--------
    rs1500955911,2
    --131443937(+) CACCTC/TAGTTG 1 -- us2k10--------
    rs1454602911,2
    --131443951(+) CAATCC/TACCTT 1 -- us2k10--------
    rs2007944131,2
    C--131443984(-) TAAGGA/CAAAAA 1 -- us2k10--------
    rs1489132551,2
    --131444076(+) GGTTGA/GGTGCG 1 -- us2k10--------
    rs1455169091,2
    C--131444081(+) GGTGCA/GGTGGC 1 -- us2k10--------
    rs1864616251,2
    C--131444369(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1136181421,2
    F--131444395(+) CAATCT/CCCACT 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1920948411,2
    C--131444452(+) CCTCCC/GGAGTA 1 -- us2k10--------
    rs1835271501,2
    --131444528(+) TTCACC/TGTGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SET (131445703 - 131458679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SET:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv27225CNV Loss19812545
    nsv825097CNV Loss20364138
    nsv893900CNV Loss21882294
    dgv1237n67CNV Gain20364138
    nsv482132CNV Gain20164927
    nsv825106CNV Gain20364138

    Human Gene Mutation Database (HGMD): SET
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SET
    DNA2.0 Custom Variant and Variant Library Synthesis for SET

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600960    OMIM disorders: --

    UniProtKB/Swiss-Prot: SET_HUMAN, Q01105
  • Note=A chromosomal aberration involving SET is found in some cases of acute undifferentiated leukemia
    (AUL). Translocation t(6;9)(q21;q34.1) with NUP214/CAN

  • 1 disease from the University of Copenhagen DISEASES database for SET:
    Progressive myoclonus epilepsy

    Find genes that share disorders with SET           About GenesLikeMe

    4 Novoseek inferred disease relationships for SET gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute undifferentiated leukemia 90.7 3 8131851 (2), 1384675 (1)
    leukemia 28.2 3 9353299 (1), 9473664 (1), 15931263 (1)
    tumors 0 4 16286244 (2), 16823850 (1), 12628186 (1)
    alzheimers disease 0 1 16162853 (1)

    Genatlas disease: SET
    acute undifferentiated leukemia (AUL);see also CAN

    Genetic Association Database (GAD): SET
    Human Genome Epidemiology (HuGE) Navigator: SET (1355 documents)
    Tumor Gene Database (TGDB): SET

    Export disorders for SET gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SET gene, integrated from 10 sources (see all 195):
    (articles sorted by number of sources associating them with SET)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. (PubMed id 8626647)1, 2, 3 Li M.... Damuni Z. (J. Biol. Chem. 1996)
    2. Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. (PubMed id 1630450)1, 2, 3 von Lindern M....Grosveld G. (Mol. Cell. Biol. 1992)
    3. Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor. (PubMed id 9773788)1, 2, 9 Carlson S.G....Ballermann B.J. (J. Am. Soc. Nephrol. 1998)
    4. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL- mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. (PubMed id 12628186)1, 2, 9 Fan Z.... Lieberman J. (Cell 2003)
    5. Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis. (PubMed id 7753797)1, 2, 9 Nagata K.... Matsumoto K. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    6. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. (PubMed id 15642345)1, 2, 9 Tsujio I.... Iqbal K. (FEBS Lett. 2005)
    7. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    8. FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. (PubMed id 19343227)1, 2 Kajiwara Y.... Buxbaum J.D. (PLoS ONE 2009)
    9. Relationship between the structure of SET/TAF-Ibeta/INHAT and its histone chaperone activity. (PubMed id 17360516)1, 2 Muto S....Horikoshi M. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    10. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6418 HGNC: 10760 AceView: SET Ensembl:ENSG00000119335 euGenes: HUgn6418
    ECgene: SET H-InvDB: SET

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SET Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SET Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SET gene:
    Search GeneIP for patents involving SET

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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