Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SET Gene

protein-coding   GIFtS: 67
GCID: GC09P131445

SET Nuclear Oncogene

(Previous name: SET translocation (myeloid leukemia-associated))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SET Nuclear Oncogene1 2     Template-Activating Factor-I1
SET Translocation (Myeloid Leukemia-Associated)1 2     2PP2A2
Protein Phosphatase Type 2A Inhibitor1 2     I2PP2A2
Inhibitor Of Granzyme A-Activated DNase2 3     IPP2A22
Phosphatase 2A Inhibitor I2PP2A2 3     TAF-IBETA2
IGAAD2 3     Inhibitor-2 Of Protein Phosphatase-2A2
PHAPII2 3     Protein SET2
TAF-I2 3     Template-Activating Factor-I, Chromatin Remodelling Factor2
HLA-DR-Associated Protein II2 3     I-2PP2A3
Chromatin Remodelling Factor1     Template-Activating Factor I3

External Ids:    HGNC: 107601   Entrez Gene: 64182   Ensembl: ENSG000001193357   OMIM: 6009605   UniProtKB: Q011053   

Export aliases for SET gene to outside databases

Previous GC identifers: GC09P122566 GC09P123092 GC09P124900 GC09P126822 GC09P128525 GC09P130485 GC09P101055


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SET Gene:
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases
(HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the
consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the
endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T
lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for SET Gene: 
SET (SET nuclear oncogene) is a protein-coding gene. Diseases associated with SET include acute undifferentiated leukemia, and glucocorticoid resistance, and among its related super-pathways are Metabolism of RNA and Destabilization of mRNA by AUF1 (hnRNP D0). GO annotations related to this gene include histone binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is TSPY6P.

UniProtKB/Swiss-Prot: SET_HUMAN, Q01105
Function: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning.
Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of
cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing
NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2
inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking
the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4.
HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both
isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform
2 specific activity is higher

Gene Wiki entry for SET (Protein SET) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SET gene promoter:
         Max   AP-1   ATF-2   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSET promoter sequence
   Search SABiosciences Chromatin IP Primers for SET

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SET


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34

SET Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SET gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P131445:  view genomic region     (about GC identifiers)

Start:
131,445,703 bp from pter      End:
131,458,679 bp from pter
Size:
12,977 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SET_HUMAN, Q01105 (See protein sequence)
Recommended Name: Protein SET  
Size: 290 amino acids; 33489 Da
Subunit: Interacts with CHTOP (By similarity). Headphone-shaped homodimer. Isoform 1 and isoform 2 interact
directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex.
Isoform 1 and isoform 2 interact also with histones. Isoform 2 is a component of the SET complex, which also
contains ANP32A, APEX1, HMGB2 and NME1, but not NME2. Within this complex, directly interacts with NME1 and with
HMGB2. Interacts with SETBP1. Interacts with SGOL1. Interacts with APBB1
Subcellular location: Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. Note=In the cytoplasm,
found both in the cytosol and associated with the endoplasmic reticulum. Following CTL attack, moves rapidly to
the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus
is also observed for lymphocyte-activated killer cells after the addition of calcium. The SET complex is
associated with the endoplasmic reticulum
1 PDB 3D structure from and Proteopedia for SET:
2E50 (3D)    
Secondary accessions: A5A5H4 A6NGV1 B4DUE2 Q15541 Q5VXV1 Q5VXV2 Q6FHZ5
Alternative splicing: 4 isoforms:  Q01105-1   Q01105-2   Q01105-3   Q01105-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for SET: NX_Q01105

Explore proteomics data for SET at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform 2 is phosphorylated on Ser-15 and Thr-23
  • UniProtKB: Isoform 2 is acetylated on Lys-11
  • UniProtKB: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and
    results in a glycine chain on the gamma-carboxyl group (By similarity)
  • UniProtKB: N-terminus of isoform 1 is methylated by METTL11A/NTM1. Mainly trimethylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01105

  • SET Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SET Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001116293.1  NP_001234929.1  NP_001234930.1  NP_003002.2  

    ENSEMBL proteins: 
     ENSP00000410806   ENSP00000361777   ENSP00000387321   ENSP00000318012   ENSP00000361771  
     ENSP00000361773  
    Reactome Protein details: Q01105
    Human Recombinant Protein Products for SET: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SET
    OriGene Protein Over-expression Lysate for SET
    OriGene MassSpec for SET 
    OriGene Custom Protein Services for SET
    GenScript Custom Purified and Recombinant Proteins Services for SET
    Novus Biologicals SET Proteins
    Novus Biologicals SET Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SET 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11555662
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA11909973
    GO:0005783endoplasmic reticulum IDA11555662
    GO:0005829cytosol IEA--

    SET for ontologies           About GeneDecksing



    SET Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SET
    OriGene Custom Antibody Services for SET
    GenScript Superior Antibodies for SET
    Novus Biologicals SET Antibodies
    Abcam antibodies for SET
    Cloud-Clone Corp. Antibodies for SET 
    ThermoFisher Antibody for SET
    LSBio Antibodies in human, mouse, rat for SET 

    Assay Products for SET: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SET
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SET
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SET 
    Cloud-Clone Corp. CLIAs for SET


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002164 NAP_family

    Graphical View of Domain Structure for InterPro Entry Q01105

    ProtoNet protein and cluster: Q01105

    1 Blocks protein domain: IPB002164 Nucleosome assembly protein (NAP)

    UniProtKB/Swiss-Prot: SET_HUMAN, Q01105
    Domain: A long alpha helix in the N-terminus mediates dimerization, while the earmuff domain is responsible for
    core histone and dsDNA binding. The C-terminal acidic domain mediates the inhibition of histone
    acetyltransferases and is required for the DNA replication stimulatory activity
    Similarity: Belongs to the nucleosome assembly protein (NAP) family


    SET for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SET_HUMAN, Q01105
    Function: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning.
    Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of
    cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing
    NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2
    inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking
    the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4.
    HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both
    isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform
    2 specific activity is higher

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004864protein phosphatase inhibitor activity TAS8626647
    GO:0005515protein binding IPI11909973
    GO:0008601protein phosphatase type 2A regulator activity TAS11555662
    GO:0042393histone binding TAS11555662
         
    SET for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SET 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SET

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SET 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SET 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SET:
    hsa-mir-199b-5p (MIRT001112)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SET
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate SET (see all 40):
    hsa-miR-411 hsa-miR-128 hsa-let-7a-2* hsa-miR-371-5p hsa-miR-3921 hsa-miR-3171 hsa-miR-502-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSET 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SET
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SET

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SET
    Sirion Biotech Customized adenovirus for overexpression of SET

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SET (see all 12)
    OriGene ORF clones in mouse, rat for SET
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SET (NM_003011)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SET
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SET
    Sirion Biotech Customized lentivirus for stable overexpression of SET 
                         Customized lentivirus expression plasmids for stable overexpression of SET 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SET
    Search LifeMap BioReagents cell lines for SET
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SET


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SET About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    2CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.63
    3Generic Transcription Pathway
    Gene Expression0.47
    4Granzyme Pathway
    Granzyme Pathway0.42
    5Activation of DNA fragmentation factor
    Granzyme-A Pathway0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SET
        Granzyme-A Pathway
    Transcriptional Regulatory Network in Embryonic Stem Cell
    Granzyme Pathway

    5        Reactome Pathways for SET
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression
    Stabilization of mRNA by HuR



    SET for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SET

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/185 Interacting proteins for SET (Q011051, 2, 3 ENSP000003617774) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST4H4P628053, ENSP000003507674I2D: score=2 STRING: ENSP00000350767
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication TAS7753797
    GO:0006334nucleosome assembly IEA--
    GO:0006337nucleosome disassembly TAS11555662
    GO:0006913nucleocytoplasmic transport NAS11555662
    GO:0010467gene expression TAS--

    SET for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SET for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SET

    1 HMDB Compound for SET    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 Novoseek inferred chemical compound relationships for SET gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 34.5 4 17374386 (1), 17512990 (1), 12540855 (1), 15869391 (1)
    serine 30.5 3 8131851 (1), 9773788 (1), 12615323 (1)
    threonine 6.48 2 9773788 (1), 12615323 (1)
    estrogen 0 4 12511607 (3)

    Search CenterWatch for drugs/clinical trials and news about SET

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SET gene (4 alternative transcripts): 
    NM_001122821.1  NM_001248000.1  NM_001248001.1  NM_003011.3  

    Unigene Cluster for SET:

    SET nuclear oncogene
    Hs.436687  [show with all ESTs]
    Unigene Representative Sequence: NM_003011
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454747 ENST00000372692(uc004bvt.4 uc022bol.1 uc011mbj.2)
    ENST00000409104 ENST00000322030(uc004bvu.4) ENST00000372686 ENST00000466009
    ENST00000477806 ENST00000480217 ENST00000480536 ENST00000485056 ENST00000372688

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SET
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate SET (see all 40):
    hsa-miR-411 hsa-miR-128 hsa-let-7a-2* hsa-miR-371-5p hsa-miR-3921 hsa-miR-3171 hsa-miR-502-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSET 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SET
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SET
    Clone
    Products:
         
    OriGene clones in human, mouse for SET (see all 12)
    OriGene ORF clones in mouse, rat for SET
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SET (NM_003011)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SET
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SET
    Sirion Biotech Customized lentivirus for stable overexpression of SET 
                         Customized lentivirus expression plasmids for stable overexpression of SET 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SET
    OriGene qSTAR qPCR primer pairs in human, mouse for SET
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SET
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SET
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SET

    Additional mRNA sequence: 

    AK223556.1 AK300609.1 AK300794.1 AK311346.1 AK315313.1 AY349172.1 BC014567.2 BC032749.1 
    BC056245.1 CR536543.1 CR542050.1 D45198.1 EF534308.1 JF729356.1 M93651.1 U51924.1 
    X75091.1 Y16698.1 Y16700.1 Y16709.1 

    24/52 DOTS entries (see all 52):

    DT.455509  DT.100684565  DT.91848738  DT.97862088  DT.91782138  DT.100684573  DT.91782177  DT.100684566 
    DT.99929024  DT.100684562  DT.91782179  DT.100059799  DT.91717929  DT.97862793  DT.100684563  DT.100684575 
    DT.91962483  DT.102842660  DT.100684561  DT.102838783  DT.91782197  DT.100749036  DT.121201580  DT.121201495 

    24/1177 AceView cDNA sequences (see all 1177):

    BU620085 BM466187 BQ224235 N91494 T94433 BM550310 BQ030311 BU508841 
    AA372731 BE046796 BI064295 AA974669 BE644754 AI753939 BI495803 AI123422 
    BE164764 BP343325 BM313286 AA328882 CD558876 BQ433447 BX460648 BU848740 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SET (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
    SP1:        -     -     -     -     -     -                       -                                             
    SP2:              -     -     -     -     -                       -                                             
    SP3:                    -     -     -     -                       -                                             
    SP4:                          -     -     -                       -                                             
    SP5:                                      -                       -                                             


    ECgene alternative splicing isoforms for SET

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SET expression in normal human tissues (normalized intensities)      SET embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTGTCTA
    SET Expression
    About this image


    SET expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             ESI-049   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See SET Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SET

    SOURCE GeneReport for Unigene cluster: Hs.436687

    UniProtKB/Swiss-Prot: SET_HUMAN, Q01105
    Tissue specificity: Widely expressed. Low levels in quiescent cells during serum starvation, contact inhibition or
    differentiation. Highly expressed in Wilms' tumor

        SABiosciences Expression via Pathway-Focused PCR Array including SET: 
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SET
    OriGene qSTAR qPCR primer pairs in human, mouse for SET
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SET
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SET
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SET
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SET

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SET gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Set1 , 5 SET nuclear oncogene1, 5 91.46(n)1
    94.46(a)1
      2 (21.09 cM)5
    560861  NM_023871.41  NP_076360.11 
     300573785 
    chicken
    (Gallus gallus)
    Aves SET1 SET nuclear oncogene 87.72(n)
    96.24(a)
      417210  NM_001030691.2  NP_001025862.2 
    lizard
    (Anolis carolinensis)
    Reptilia SET6
    Uncharacterized protein
    77(a)
    1 ↔ 1
    AAWZ02037496(1699-2802)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056839.12   -- 82.07(n)    BC056839.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.282392 Danio rerio clone RK071A2C04 myeloid leukemia-associated more 77.72(n)    AY398416.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Set1 , 3 cyclin binding3
    CG4299-PA1
    65(a)3
    61.09(n)1
    61.48(a)1
      88E83
    418441  NM_142181.21  NP_650438.21 
    worm
    (Caenorhabditis elegans)
    Secernentea spr-21 , 3 SET protein3
    Protein SPR-21
    39(a)3
    55.7(n)1
    46.15(a)1
      IV(8891548-8892716)3
    1777041  NM_001026162.31  NP_001021333.11 
    rice
    (Oryza sativa)
    Liliopsida AK109192.12   -- 70.57(n)    AK109192.1 


    ENSEMBL Gene Tree for SET (if available)
    TreeFam Gene Tree for SET (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SET gene
    TSPY6P2  TSPYL12  TSPYL62  TSPY42  TSPY12  TSPY82  TSPYL22  TSPYL52  
    TSPYL42  TSPY102  TSPY22  TSPY32  
    12 SIMAP similar genes for SET using alignment to 3 protein entries:     SET_HUMAN (see all proteins):
    TSPY26P    TSPYL4    LOC728395    TSPYL    TSPYL5    TSPY10
    TSPY2    TSPY4    TSPY8    TSPY1    TSPY3    TSPY6P

    SET for paralogs           About GeneDecksing


    5/21 Pseudogenes.org Pseudogenes for SET (see all 21)
    PGOHUM00000242502 PGOHUM00000242834 PGOHUM00000239917 PGOHUM00000247729 PGOHUM00000248167


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/315 SNPs in SET are shown (see all 315)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460673281,2
    C--101059816(+) CTCCC-/GCCTG 
    TAATCCCA
    GCACT
    1 -- int10--------
    rs1500955911,2
    --131443937(+) CACCTC/TAGTTG 1 -- us2k10--------
    rs1454602911,2
    --131443951(+) CAATCC/TACCTT 1 -- us2k10--------
    rs2007944131,2
    C--131443984(-) TAAGGA/CAAAAA 1 -- us2k10--------
    rs1489132551,2
    --131444076(+) GGTTGA/GGTGCG 1 -- us2k10--------
    rs1455169091,2
    C--131444081(+) GGTGCA/GGTGGC 1 -- us2k10--------
    rs1864616251,2
    C--131444369(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1136181421,2
    F--131444395(+) CAATCT/CCCACT 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1920948411,2
    C--131444452(+) CCTCCC/GGAGTA 1 -- us2k10--------
    rs1835271501,2
    --131444528(+) TTCACC/TGTGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SET (131445703 - 131458679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SET:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv27225CNV Loss19812545
    nsv825097CNV Loss20364138
    nsv893900CNV Loss21882294
    dgv1237n67CNV Gain20364138
    nsv482132CNV Gain20164927
    nsv825106CNV Gain20364138


    Human Gene Mutation Database (HGMD): SET
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SET
    DNA2.0 Custom Variant and Variant Library Synthesis for SET

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600960    OMIM disorders: --

    UniProtKB/Swiss-Prot: SET_HUMAN, Q01105
  • Note=A chromosomal aberration involving SET is found in some cases of acute undifferentiated leukemia
    (AUL). Translocation t(6;9)(q21;q34.1) with NUP214/CAN

  • 20/26 diseases for SET (see all 26):    About MalaCards
    acute undifferentiated leukemia    glucocorticoid resistance    west nile virus    myeloid leukemia
    measles    wilms tumor    acute myeloid leukemia    acute lymphoblastic leukemia
    leukemia    oral squamous cell carcinoma    choroiditis    intrahepatic cholangiocarcinoma
    choriocarcinoma    medulloblastoma    cholangiocarcinoma    malaria
    non-hodgkin lymphoma    hodgkin's lymphoma    lymphoblastic leukemia    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for SET:
    Progressive myoclonus epilepsy

    SET for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for SET gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute undifferentiated leukemia 90.7 3 8131851 (2), 1384675 (1)
    leukemia 28.2 3 9353299 (1), 9473664 (1), 15931263 (1)
    tumors 0 4 16286244 (2), 16823850 (1), 12628186 (1)
    alzheimers disease 0 1 16162853 (1)

    Genatlas disease: SET
    acute undifferentiated leukemia (AUL);see also CAN

    Genetic Association Database (GAD): SET
    Human Genome Epidemiology (HuGE) Navigator: SET (1355 documents)
    Tumor Gene Database (TGDB): SET

    Export disorders for SET gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SET gene, integrated from 9 sources (see all 191):
    (articles sorted by number of sources associating them with SET)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. (PubMed id 8626647)1, 2, 3 Li M....Damuni Z. (1996)
    2. Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. (PubMed id 1630450)1, 2, 3 von Lindern M....Grosveld G. (1992)
    3. Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor. (PubMed id 9773788)1, 2, 9 Carlson S.G....Ballermann B.J. (1998)
    4. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL- mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. (PubMed id 12628186)1, 2, 9 Fan Z.... Lieberman J. (2003)
    5. Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis. (PubMed id 7753797)1, 2, 9 Nagata K.... Matsumoto K. (1995)
    6. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. (PubMed id 15642345)1, 2, 9 Tsujio I.... Iqbal K. (2005)
    7. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    8. FE65 binds Teashirt, inhibiting expression of the pri mate-specific caspase-4. (PubMed id 19343227)1, 2 Kajiwara Y....Buxbaum J.D. (2009)
    9. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
    10. Relationship between the structure of SET/TAF-Ibeta/INHAT and its histone chaperone activity. (PubMed id 17360516)1, 2 Muto S....Horikoshi M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6418 HGNC: 10760 AceView: SET Ensembl:ENSG00000119335 euGenes: HUgn6418
    ECgene: SET H-InvDB: SET

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SET Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SET Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SET gene:
    Search GeneIP for patents involving SET

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SET   OriGene RNAi products in human, mouse, rat for SET  
     OriGene qPCR primer pairs and template standards for SET   OriGene Protein Over-expression Lysate for SET  
     OriGene MassSpec something-or-other for SET   OriGene clones in human, mouse for SET  
     OriGene qSTAR qPCR primer pairs in human, mouse for SET   OriGene Purified Protein for SET  
     OriGene ORF clones in mouse, rat for SET   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SET   OriGene Custom Protein Services for SET  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SET
     QIAGEN SeqTarget long-range PCR primers for resequencing SET
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SET
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SET
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SET
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SET
     GenScript Custom Purified and Recombinant Proteins Services for SET GenScript cDNA clones with any tag delivered in your preferred vector for SET
     GenScript Custom Assay Services for SET GenScript Superior Antibodies for SET
     GenScript Custom overexpressing Cell Line Services for SET CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SET promoter
     Search Chromatin IP Primers for SET
     RT2 qPCR Primer Assay in human, mouse, rat SET
     GNC Network for SET
     SABiosciences PCR Arrays including human, mouse, rat SET
     Search Tocris compounds for SET
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SET antibodies
     SET proteins
     SET lysates
     Antibodies for SET
     See all of Abcam's Antibodies, Kits and Proteins for SET
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SET
     Antibodies for SET
     ELISAs for SET
     CLIAs for SET
     Search LifeMap BioReagents cell lines for SET
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SET
     SwitchGear 3'UTR luciferase reporter plasmids for SET
     SwitchGear Promoter luciferase reporter plasmids for SET
     ThermoFisher Antibody for SET
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SET
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SET
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SET
    Customized:
     lentivirus for stable overexpression of SET
     lentivirus expression plasmids for stable overexpression of SET
     adenovirus for overexpression of SET
     LSBio Antibodies in human, mouse, rat for SET
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SET gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4