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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SET Gene

protein-coding   GIFtS: 64
GCID: GC09P131445

SET nuclear oncogene

(Previous name: SET translocation (myeloid leukemia-associated) )
 Explore 27 diseases affiliated with
SET via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SET    

Aliases
for SET gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SET Nuclear Oncogene1 2     HLA-DR-Associated Protein II2 3
PHAPII1 2 3     I2PP2A2
2PP2A1 2     TAF-IBETA2
IPP2A21 2     Inhibitor-2 Of Protein Phosphatase-2A2
SET Translocation (Myeloid Leukemia-Associated)1 2     Protein Phosphatase Type 2A Inhibitor2
Inhibitor Of Granzyme A-Activated DNase2 3     Protein SET2
Phosphatase 2A Inhibitor I2PP2A2 3     Template-Activating Factor-I, Chromatin Remodelling Factor2
IGAAD2 3     I-2PP2A3
TAF-I2 3     Template-Activating Factor I3

External Ids:    HGNC: 107601   Entrez Gene: 64182   Ensembl: ENSG000001193357   OMIM: 6009605   UniProtKB: Q011053   

Export aliases for SET gene to outside databases

Previous GC identifers: GC09P122566 GC09P123092 GC09P124900 GC09P126822 GC09P128525 GC09P130485 GC09P101055


Summaries
for SET gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SET:
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases
(HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the
consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the
endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes.
This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: SET_HUMAN, Q01105
Function: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning.
Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of
cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1
inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit
EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the
accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT
inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms
stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific
activity is higher

Gene Wiki entry for SET (Protein SET)


Genomic Views
for SET gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SET gene promoter:
         Max   AP-1   ATF-2   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SET promoter sequence
   Search SABiosciences Chromatin IP Primers for SET

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SET


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34

SET Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SET gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P131445:  view genomic region     (about GC identifiers)

Start:
 131,445,703 bp from pter      End:
 131,458,679 bp from pter
Size:
 12,977 bases      Orientation:
 plus strand

Proteins
for SET gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SET_HUMAN, Q01105 (See protein sequence)
Recommended Name: Protein SET  
Size: 290 amino acids; 33489 Da
Subunit: Interacts with CHTOP (By similarity). Headphone-shaped homodimer. Isoform 1 and isoform 2 interact directly
with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex. Isoform 1 and
isoform 2 interact also with histones. Isoform 2 is a component of the SET complex, which also contains ANP32A, APEX1,
HMGB2 and NME1, but not NME2. Within this complex, directly interacts with NME1 and with HMGB2. Interacts with SETBP1.
Interacts with SGOL1. Interacts with APBB1
Subcellular location: Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. Note=In the cytoplasm, found
both in the cytosol and associated with the endoplasmic reticulum. Following CTL attack, moves rapidly to the nucleus,
where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed
for lymphocyte-activated killer cells after the addition of calcium. The SET complex is associated with the
endoplasmic reticulum
1 PDB 3D structure from and Proteopedia for SET:
2E50 (3D)    
Secondary accessions: A5A5H4 A6NGV1 B4DUE2 Q15541 Q5VXV1 Q6FHZ5
Alternative splicing: 3 isoforms:  Q01105-1   Q01105-2   Q01105-3   (Contains a phosphoserine at position 15. Variant in position: 4:P->Q (in dbSNP:rs1141138). Contains a N6-acetyllysine at position 11. Contains a phosphoserine at position 24)

Explore the universe of human proteins at neXtProt for SET: NX_Q01105

Post-translational modifications:

  • Isoform 2 is phosphorylated on Ser-15 and Thr-231
  • Isoform 2 is acetylated on Lys-111
  • Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results
    • in a glycine chain on the gamma-carboxyl group (By similarity)1
  • N-terminus of isoform 1 is methylated by METTL11A/NTM1. Mainly trimethylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01105

    • SET Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001116293.1  NP_001234929.1  NP_001234930.1  NP_003002.2  

    ENSEMBL proteins: 
     ENSP00000410806   ENSP00000361777   ENSP00000387321   ENSP00000318012   ENSP00000361771  
     ENSP00000361773  
    Reactome Protein details: Q01105
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SET
    OriGene Protein Over-expression Lysate: SET
    OriGene Custom Protein Services for SET 
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    Novus Biologicals SET Protein
    Novus Biologicals SET Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SET

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11555662
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA12524539
    GO:0005783endoplasmic reticulum IDA12524539
    GO:0005829cytosol IEA--


    SET for ontologies           About GeneDecksing



    SET Antibody Products: 
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    OriGene Antibodies (see all 2): SET
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    Novus Biologicals SET Antibodies
    Search for Antibodies for SET at Abcam  
    Uscn Antibodies for SET
    ThermoFisher Antibody for SET

    Assay Products for SET: 
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    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SET
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    Uscn ELISAs and CLIAs for SET

    Protein Domains /
    Families
    for SET gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SET for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002164 NAP_family

    Graphical View of Domain Structure for InterPro Entry Q01105

    ProtoNet protein and cluster: Q01105

    1 Blocks protein family: IPB002164 Nucleosome assembly protein (NAP)

    UniProtKB/Swiss-Prot: SET_HUMAN, Q01105
    Domain: A long alpha helix in the N-terminus mediates dimerization, while the earmuff domain is responsible for core
    histone and dsDNA binding. The C-terminal acidic domain mediates the inhibition of histone acetyltransferases and is
    required for the DNA replication stimulatory activity
    Similarity: Belongs to the nucleosome assembly protein (NAP) family


    Function
    for SET gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SET_HUMAN, Q01105
    Function: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning.
    Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of
    cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1
    inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit
    EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the
    accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT
    inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms
    stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific
    activity is higher

    miRNA
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    hsa-mir-199b-5p (MIRT001112)

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    hsa-miR-411 hsa-miR-128 hsa-let-7a-2* hsa-miR-371-5p hsa-miR-3921 hsa-miR-3171 hsa-miR-502-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SET 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SET
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SET (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SET (NM_003011)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SET 

    Cell Line
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    Search LifeMap BioReagents cell lines for SET

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SET

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004864protein phosphatase inhibitor activity TAS8626647
    GO:0005515protein binding IPI--
    GO:0008601protein phosphatase type 2A regulator activity TAS11555662
    GO:0042393histone binding TAS11555662


    SET for ontologies           About GeneDecksing



    Pathways & Interactions
    for SET gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Stabilization of mRNA by HuR
    		Stabilization of mRNA by HuR1.00
    		Export of HuR:mRNA Complex from the Nucleus to the Cytoplasm0.75
    2Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    3Transcriptional Regulatory Network in Embryonic Stem Cell
    		Transcriptional Regulatory Network in Embryonic Stem Cell1.00
    4Granzyme Pathway
    		Granzyme Pathway1.00
    5Ubiquitinated Orc1 is degraded by the proteasome
    		Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.55

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SET
        Granzyme-A Pathway
    Transcriptional Regulatory Network in Embryonic Stem Cell
    Granzyme Pathway

    5/6        Reactome Pathways for SET (see all 6)
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Metabolism of RNA
    Metabolism of mRNA
    Export of HuR:mRNA Complex from the Nucleus to the Cytoplasm
    Gene Expression



    SET for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SET

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/183 Interacting proteins for SET (Q011051, 2, 3 ENSP000003617774) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST4H4P628053, ENSP000003507674I2D: score=2 STRING: ENSP00000350767
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication TAS7753797
    GO:0006334nucleosome assembly IEA--
    GO:0006337nucleosome disassembly TAS11555662
    GO:0006913nucleocytoplasmic transport NAS11555662
    GO:0010467gene expression TAS--


    SET for ontologies           About GeneDecksing



    Drugs & Compounds
    for SET gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SET for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SET

    1 HMDB Compound for SET    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    4 Novoseek chemical compound relationships for SET gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 34.5 4 17374386 (1), 17512990 (1), 12540855 (1), 15869391 (1)
    serine 30.5 3 8131851 (1), 9773788 (1), 12615323 (1)
    threonine 6.48 2 9773788 (1), 12615323 (1)
    estrogen 0 4 12511607 (3)

    Search CenterWatch for drugs/clinical trials and news about SET 

    Transcripts
    for SET gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SET gene (4 alternative transcripts): 
    NM_001122821.1  NM_001248000.1  NM_001248001.1  NM_003011.3  

    Unigene Cluster for SET:

    SET nuclear oncogene
    Hs.436687  [show with all ESTs]
    Unigene Representative Sequence: NM_003011
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454747 ENST00000372692(uc004bvt.4 uc022bol.1 uc011mbj.2)
    ENST00000409104 ENST00000322030(uc004bvu.4) ENST00000494141 ENST00000372686
    ENST00000466009 ENST00000477806 ENST00000480217 ENST00000480536 ENST00000485056
    ENST00000372688

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SET
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate SET (see all 40):
    hsa-miR-411 hsa-miR-128 hsa-let-7a-2* hsa-miR-371-5p hsa-miR-3921 hsa-miR-3171 hsa-miR-502-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SET 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SET (see all 4)
    OriGene shRNA RFP: SET
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SET
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SET (NM_003011)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SET 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SET
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SET

    Additional cDNA sequence: 

    AK223556.1 AK300609.1 AK300794.1 AK311346.1 AK315313.1 AY349172.1 BC014567.2 BC032749.1 
    BC056245.1 CR536543.1 CR542050.1 D45198.1 EF534308.1 JF729356.1 M93651.1 U51924.1 
    X75091.1 

    24/44 DOTS entries (see all 44):

    DT.91848738  DT.100684565  DT.455509  DT.100684566  DT.100684562  DT.97862088  DT.91782138  DT.91782177 
    DT.100684573  DT.91782179  DT.97862793  DT.100684563  DT.100684575  DT.91717929  DT.99929024  DT.100059799 
    DT.100684561  DT.102842660  DT.102838783  DT.91782197  DT.100749036  DT.121201580  DT.91962483  DT.121201495 

    24/1177 AceView cDNA sequences (see all 1177):

    BQ004089 CA419483 AI309210 AI355458 BM825151 AA313621 BQ949329 CR602404 
    BM915046 AI635258 CA416851 AI676220 CR594714 BI093489 CA392110 BM993025 
    AW192632 BQ049563 BQ775736 BU500235 AA328882 BM838936 BF432079 CB119181 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SET (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
    SP1:        -     -     -     -     -     -                       -                                             
    SP2:              -     -     -     -     -                       -                                             
    SP3:                    -     -     -     -                       -                                             
    SP4:                          -     -     -                       -                                             
    SP5:                                      -                       -                                             


    ECgene alternative splicing isoforms for SET

    Expression
    for SET gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SET expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATCTGTCTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SET Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SET

    SOURCE GeneReport for Unigene cluster: Hs.436687

    UniProtKB/Swiss-Prot: SET_HUMAN, Q01105
    Tissue specificity: Widely expressed. Low levels in quiescent cells during serum starvation, contact inhibition or
    differentiation. Highly expressed in Wilms' tumor

        SABiosciences Expression via Pathway-Focused PCR Array including SET: 
              Tumor Metastasis in human mouse rat

    Primer
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    Orthologs
    for SET gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SET gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SET1 SET nuclear oncogene 87.72(n)
    96.24(a)    		   417210  NM_001030691.2  NP_001025862.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SET6
    		 --
    		 95(a)
    		 1 ↔ 1
    		 AAWZ02037496(1993-2339)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC056839.12   -- 82.07(n)    BC056839.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.282392 Danio rerio clone RK071A2C04 myeloid leukemia-associated more 77.72(n)    AY398416.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Set1 , 3 cyclin binding3
    CG4299-PA1    		 65(a)3
    61.09(n)1
    61.48(a)1    		   88E83
    418441  NM_142181.21  NP_650438.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea spr-21 , 3 SET protein3
    Protein SPR-21    		 39(a)3
    55.7(n)1
    46.15(a)1    		   IV(8891548-8892716)3
    1777041  NM_001026162.31  NP_001021333.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NRP26
    NRP16
    		 template-activating factor I
    		 38(a)
    33(a)
    		 many ↔ many
    many ↔ many
    		 1(6481113-6483596)
    1(28017584-28020049)
    rice
    (Oryza sativa)    		 Liliopsida AK109192.12   -- 70.57(n)    AK109192.1 


    ENSEMBL Gene Tree for SET (if available)
    TreeFam Gene Tree for SET (if available) 

    Paralogs
    for SET gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SET gene
    TSPYL12  TSPYL62  TSPY42  TSPY12  TSPY82  TSPYL22  TSPYL52  TSPYL42  
    TSPY102  TSPY22  TSPY32  
    12 SIMAP similar genes for SET using alignment to 4 protein entries:     SET_HUMAN (see all proteins):
    TSPY26P    TSPYL4    LOC728395    TSPYL    TSPYL5    TSPY10
    TSPY2    TSPY4    TSPY8    DKFZp434M235    TSPY1    TSPY3

    SET for paralogs           About GeneDecksing


    5/21 Pseudogenes.org Pseudogenes for SET (see all 21)
    PGOHUM00000242502 PGOHUM00000242834 PGOHUM00000239917 PGOHUM00000247729 PGOHUM00000248167


    Genomic Variants
    for SET gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/243 NCBI SNPs in SET are shown (see all 243)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1500955911,2
    		--131443937(+) CACCTC/TAGTTG 1 -- us2k10--------
    rs1454602911,2
    		--131443951(+) CAATCC/TACCTT 1 -- us2k10--------
    rs2007944131,2
    		C--131443984(-) TAAGGA/CAAAAA 1 -- us2k10--------
    rs1489132551,2
    		--131444076(+) GGTTGA/GGTGCG 1 -- us2k10--------
    rs1455169091,2
    		--131444081(+) GGTGCA/GGTGGC 1 -- us2k10--------
    rs1864616251,2
    		--131444369(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1136181421,2
    		--131444395(+) CAATCT/CCCACT 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1920948411,2
    		--131444452(+) CCTCCC/GGAGTA 1 -- us2k10--------
    rs1835271501,2
    		--131444528(+) TTCACC/TGTGTT 1 -- us2k10--------
    rs70269871,2
    		C,--131444763(+) CCAGCG/CTGGGC 1 -- us2k110Minor allele frequency- C:0.06WA NA CSA EA 372

    HapMap Linkage Disequilibrium report for SET (131445703 - 131458679 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for SET
         5 CNVs: 83194 83195 96311 96310 65526
         2 Indels: 83196 96312
    Human Gene Mutation Database (HGMD): SET

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    Disorders / Diseases
    for SET gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SET for disorders           About GeneDecksing

    OMIM gene information: 600960    OMIM disorders: --

    UniProtKB/Swiss-Prot: SET_HUMAN, Q01105
  • Note=A chromosomal aberration involving SET is found in some cases of acute undifferentiated leukemia (AUL).
    • Translocation t(6;9)(q21;q34.1) with NUP214/CAN

    20/27 diseases for SET (see all 27):    About MalaCards
    myeloid leukemia    west nile virus    leukemia    non-hodgkin lymphoma
    glucocorticoid resistance    oral squamous cell carcinoma    squamous cell carcinoma    hodgkin's lymphoma
    acute lymphoblastic leukemia    lymphoblastic leukemia    acute myeloid leukemia    intrahepatic cholangiocarcinoma
    epithelial ovarian cancer    wilms tumor    ovarian cancer    cholangiocarcinoma
    measles    choriocarcinoma    medulloblastoma    hepatocellular carcinoma

    4 Novoseek disease relationships for SET gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute undifferentiated leukemia 90.7 3 8131851 (2), 1384675 (1)
    leukemia 28.2 3 9353299 (1), 9473664 (1), 15931263 (1)
    tumors 0 4 16286244 (2), 16823850 (1), 12628186 (1)
    alzheimers disease 0 1 16162853 (1)

    Genatlas disease: SET
    acute undifferentiated leukemia (AUL);see also CAN

    Human Genome Epidemiology (HuGE) Navigator: SET (1355 documents)
    Tumor Gene Database (TGDB): SET

    Export disorders for SET gene to outside databases

    Publications
    for SET gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SET gene, integrated from 9 sources (see all 178):
    (articles sorted by number of sources associating them with SET)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. (PubMed id 8626647)1, 2, 3 Li M....Damuni Z. (1996)
    2. Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. (PubMed id 1630450)1, 2, 3 von Lindern M....Grosveld G. (1992)
    3. Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor. (PubMed id 9773788)1, 2, 9 Carlson S.G....Ballermann B.J. (1998)
    4. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL- mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. (PubMed id 12628186)1, 2, 9 Fan Z.... Lieberman J. (2003)
    5. Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis. (PubMed id 7753797)1, 2, 9 Nagata K.... Matsumoto K. (1995)
    6. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. (PubMed id 15642345)1, 2, 9 Tsujio I.... Iqbal K. (2005)
    7. FE65 binds Teashirt, inhibiting expression of the pri mate-specific caspase-4. (PubMed id 19343227)1, 2 Kajiwara Y....Buxbaum J.D. (2009)
    8. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
    9. Relationship between the structure of SET/TAF-Ibeta/INHAT and its histone chaperone activity. (PubMed id 17360516)1, 2 Muto S....Horikoshi M. (2007)
    10. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (2006)

    External Searches for SET gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SET gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6418 HGNC: 10760 AceView: SET Ensembl:ENSG00000119335 euGenes: HUgn6418
    ECgene: SET H-InvDB: SET

    Other Databases showing SET gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SET gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SET Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SET Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SET gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SET gene:
    Search GeneIP for patents involving SET

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SET gene

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    About This Section

     
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