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Aliases for SET Gene

Aliases for SET Gene

  • SET Nuclear Proto-Oncogene 2 3
  • SET Translocation (Myeloid Leukemia-Associated) 2 3
  • Inhibitor Of Granzyme A-Activated DNase 3 4
  • Protein Phosphatase Type 2A Inhibitor 2 3
  • Phosphatase 2A Inhibitor I2PP2A 3 4
  • HLA-DR-Associated Protein II 3 4
  • PHAPII 3 4
  • IGAAD 3 4
  • TAF-I 3 4
  • Template-Activating Factor-I, Chromatin Remodelling Factor 3
  • Inhibitor-2 Of Protein Phosphatase-2A 3
  • Template-Activating Factor-I 2
  • Chromatin Remodelling Factor 2
  • Template-Activating Factor I 4
  • SET Nuclear Oncogene 3
  • Protein SET 3
  • TAF-IBETA 3
  • I-2PP2A 4
  • I2PP2A 3
  • IPP2A2 3
  • 2PP2A 3

External Ids for SET Gene

Previous GeneCards Identifiers for SET Gene

  • GC09P122566
  • GC09P123092
  • GC09P124900
  • GC09P126822
  • GC09P128525
  • GC09P130485
  • GC09P131445
  • GC09P101055

Summaries for SET Gene

Entrez Gene Summary for SET Gene

  • The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SET Gene

SET (SET Nuclear Proto-Oncogene) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include histone binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is TSPY2.

UniProtKB/Swiss-Prot for SET Gene

  • Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.

Gene Wiki entry for SET Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SET Gene

Genomics for SET Gene

Regulatory Elements for SET Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SET Gene

Start:
128,683,424 bp from pter
End:
128,696,400 bp from pter
Size:
12,977 bases
Orientation:
Plus strand

Genomic View for SET Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SET Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SET Gene

Proteins for SET Gene

  • Protein details for SET Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01105-SET_HUMAN
    Recommended name:
    Protein SET
    Protein Accession:
    Q01105
    Secondary Accessions:
    • A5A5H4
    • A6NGV1
    • B4DUE2
    • Q15541
    • Q5VXV1
    • Q5VXV2
    • Q6FHZ5

    Protein attributes for SET Gene

    Size:
    290 amino acids
    Molecular mass:
    33489 Da
    Quaternary structure:
    • Headphone-shaped homodimer. Isoforms 1 and 2 interact directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex. Isoform 1 and isoform 2 interact also with histones. Isoform 2 is a component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1, but not NME2 or TREX2. Within this complex, directly interacts with ANP32A, NME1, HMGB2 and TREX1; the interaction with ANP32A is enhanced after cleavage. Interacts with APBB1, CHTOP, SETBP1, SGOL1. Interacts with herpes simplex virus 1 VP22.

    Three dimensional structures from OCA and Proteopedia for SET Gene

    Alternative splice isoforms for SET Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SET Gene

Proteomics data for SET Gene at MOPED

Post-translational modifications for SET Gene

  • Isoform 2 is acetylated on Lys-11
  • Isoform 2 is cleaved after Lys-176 by GZMA. The cleavage inhibits its nucelosome assembly activity and disrupts the inhibition on NME1.
  • Isoform 2 is phosphorylated on Ser-15 and Thr-23
  • N-terminus of isoform 1 is methylated by METTL11A/NTM1. Mainly trimethylated (By similarity).
  • Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).
  • Ubiquitination at Lys83, Lys132, Lys150, Lys154, Lys167, and Lys172
  • Modification sites at PhosphoSitePlus

Other Protein References for SET Gene

Antibody Products

No data available for DME Specific Peptides for SET Gene

Domains for SET Gene

Protein Domains for SET Gene

Graphical View of Domain Structure for InterPro Entry

Q01105

UniProtKB/Swiss-Prot:

SET_HUMAN :
  • Q01105
Domain:
  • A long alpha helix in the N-terminus mediates dimerization, while the earmuff domain is responsible for core histone and dsDNA binding. The C-terminal acidic domain mediates the inhibition of histone acetyltransferases and is required for the DNA replication stimulatory activity.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with SET: view

No data available for Gene Families for SET Gene

Function for SET Gene

Molecular function for SET Gene

UniProtKB/Swiss-Prot Function:
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.

Gene Ontology (GO) - Molecular Function for SET Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004864 protein phosphatase inhibitor activity TAS 8626647
GO:0005515 protein binding IPI 11909973
GO:0008601 protein phosphatase type 2A regulator activity TAS 11555662
GO:0042393 histone binding TAS 11555662
genes like me logo Genes that share ontologies with SET: view

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SET Gene

Localization for SET Gene

Subcellular locations from UniProtKB/Swiss-Prot for SET Gene

Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. Note=In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SET Gene COMPARTMENTS Subcellular localization image for SET gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SET Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 11909973
GO:0005783 endoplasmic reticulum IDA 11555662
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with SET: view

Pathways for SET Gene

genes like me logo Genes that share pathways with SET: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SET Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006260 DNA replication TAS 7753797
GO:0006334 nucleosome assembly IEA --
GO:0006337 nucleosome disassembly TAS 11555662
GO:0006913 nucleocytoplasmic transport NAS 11555662
genes like me logo Genes that share ontologies with SET: view

Compounds for SET Gene

(1) HMDB Compounds for SET Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(4) Novoseek inferred chemical compound relationships for SET Gene

Compound -log(P) Hits PubMed IDs
lysine 34.5 4
serine 30.5 3
threonine 6.48 2
estrogen 0 3
genes like me logo Genes that share compounds with SET: view

Transcripts for SET Gene

Unigene Clusters for SET Gene

SET nuclear oncogene:
Representative Sequences:

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SET Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for SET Gene

GeneLoc Exon Structure for
SET
ECgene alternative splicing isoforms for
SET

Expression for SET Gene

mRNA expression in normal human tissues for SET Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SET Gene

SOURCE GeneReport for Unigene cluster for SET Gene Hs.436687

mRNA Expression by UniProt/SwissProt for SET Gene

Q01105-SET_HUMAN
Tissue specificity: Widely expressed. Low levels in quiescent cells during serum starvation, contact inhibition or differentiation. Highly expressed in Wilms tumor
genes like me logo Genes that share expressions with SET: view

Expression partners for SET Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for SET Gene

Orthologs for SET Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SET Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SET 35
  • 95.67 (n)
  • 99.64 (a)
-- 36
  • 86 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
SET 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SET 35
  • 96.44 (n)
  • 100 (a)
-- 36
  • 45 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Set 35
  • 93.81 (n)
  • 98.42 (a)
Set 16
Set 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SET 35
  • 99.74 (n)
  • 100 (a)
SET 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Set 35
  • 94.83 (n)
  • 98.5 (a)
oppossum
(Monodelphis domestica)
Mammalia SET 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SET 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves SET 35
  • 90.97 (n)
  • 100 (a)
SET 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SET 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia set 35
  • 84.6 (n)
  • 98.65 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.28239 35
setb 35
  • 81.02 (n)
  • 95.96 (a)
seta 36
  • 83 (a)
OneToMany
setb 36
  • 87 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9243 35
fruit fly
(Drosophila melanogaster)
Insecta Set 37
  • 65 (a)
Set 35
  • 60.8 (n)
  • 63.43 (a)
Set 36
  • 59 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003598 35
  • 59.18 (n)
  • 60.71 (a)
worm
(Caenorhabditis elegans)
Secernentea spr-2 37
  • 39 (a)
spr-2 35
  • 52.72 (n)
  • 44.57 (a)
spr-2 36
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NRP1 35
  • 56.91 (n)
  • 45.74 (a)
rice
(Oryza sativa)
Liliopsida Os02g0576700 35
  • 56.81 (n)
  • 44.13 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3127 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4858 36
  • 63 (a)
OneToOne
Species with no ortholog for SET:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SET Gene

ENSEMBL:
Gene Tree for SET (if available)
TreeFam:
Gene Tree for SET (if available)

Paralogs for SET Gene

Selected SIMAP similar genes for SET Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SET: view

Variants for SET Gene

Sequence variations from dbSNP and Humsavar for SET Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1061240 -- 128,694,976(+) CCCTT(C/T)GCTCT utr-variant-3-prime
rs1141138 -- 128,689,593(+) GGCGC(A/C)GGCGG intron-variant, upstream-variant-2KB, missense, reference
rs1141306 -- 128,695,960(+) TGGCT(A/C)TATAA utr-variant-3-prime
rs3750330 -- 128,691,841(-) GAAAA(A/G)AGATG intron-variant
rs3750331 -- 128,691,724(-) CACCT(A/C)ATTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SET Gene

Variant ID Type Subtype PubMed ID
nsv825097 CNV Loss 20364138
dgv1237n67 CNV Gain 20364138
nsv893900 CNV Loss 21882294
nsv482132 CNV Gain 20164927
nsv825106 CNV Gain 20364138
esv27225 CNV Loss 19812545

Relevant External Links for SET Gene

HapMap Linkage Disequilibrium report
SET
Human Gene Mutation Database (HGMD)
SET

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SET Gene

Disorders for SET Gene

UniProtKB/Swiss-Prot

SET_HUMAN
  • Note=A chromosomal aberration involving SET is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with NUP214/CAN.

(1) University of Copenhagen DISEASES for SET Gene

(4) Novoseek inferred disease relationships for SET Gene

Disease -log(P) Hits PubMed IDs
acute undifferentiated leukemia 90.7 3
leukemia 28.2 3
tumors 0 4
alzheimers disease 0 1

Genatlas disease for SET Gene

acute undifferentiated leukemia (AUL);see also CAN

Relevant External Links for SET

Genetic Association Database (GAD)
SET
Human Genome Epidemiology (HuGE) Navigator
SET
Tumor Gene Database (TGDB):
SET
genes like me logo Genes that share disorders with SET: view

No data available for MalaCards and OMIM for SET Gene

Publications for SET Gene

  1. Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis. (PMID: 7753797) Nagata K. … Matsumoto K. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4 23
  2. Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor. (PMID: 9773788) Carlson S.G. … Ballermann B.J. (J. Am. Soc. Nephrol. 1998) 3 4 23
  3. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL- mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. (PMID: 12628186) Fan Z. … Lieberman J. (Cell 2003) 3 4 23
  4. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. (PMID: 15642345) Tsujio I. … Iqbal K. (FEBS Lett. 2005) 3 4 23
  5. Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. (PMID: 1630450) von Lindern M. … Grosveld G. (Mol. Cell. Biol. 1992) 2 3 4

Products for SET Gene

  • Addgene plasmids for SET

Sources for SET Gene

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