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Set Analyses:

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SESTD1 Gene

protein-coding GIFtS: 52
GCID: GC02M179966

SEC14 And Spectrin Domains 1

Pneumococci & Pneumococcal Diseases Congress

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
SEC14 And Spectrin Domains 1¹ ²
Huntingtin-Interacting Protein-Like Protein² ³
Protein Solo² ³
SOLO² ³
SEC14 Domain And Spectrin Repeat-Containing Protein 1²

External Ids:	HGNC: 18379¹	Entrez Gene: 91404²	Ensembl: ENSG00000187231⁷	UniProtKB: Q86VW0³

Export aliases for SESTD1 gene to outside databases

Previous GC identifers: GC00U991235 GC02M180176 GC02M179799 GC02M179681 GC02M171835

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SESTD1 Gene:

SESTD1 (SEC14 and spectrin domains 1) is a protein-coding gene. Diseases associated with SESTD1 include hiv-1, and malaria. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot: SESD1_HUMAN, Q86VW0

Function: May act as the primary docking protein directing membrane turnover and assembly of the transient

receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates,

phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including

phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent.

Might be involved in the plasma membrane localization of CTNNB1

Gene Wiki entry for SESTD1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000002.12 NT_005403.18 NC_018913.2

Regulatory elements:

Regulatory transcription factor binding sites in the SESTD1 gene promoter:
AML1a FOXO3 Meis-1b FOXO3b AREB6 FOXO4 FOXO3a POU2F1c Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SESTD1 promoter sequence

Search Chromatin IP Primers for SESTD1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SESTD1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.2 Ensembl cytogenetic band: 2q31.2 HGNC cytogenetic band: 2q31.3

SESTD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SESTD1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M179966: view genomic region (about GC identifiers)

Start:	179,966,419 bp from pter	End:	180,129,517 bp from pter
Size:	163,099 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SESD1_HUMAN, Q86VW0 (See protein sequence)

Recommended Name: SEC14 domain and spectrin repeat-containing protein 1

Size: 696 amino acids; 79348 Da

Subunit: Interacts (via the spectrin 1 repeat) with TRPC4 and TRPC5 (via CIRB domain). Interacts with CTNNB1

Miscellaneous: Called SOLO because the encoded protein is related to but shorter than DUO and TRIO

Sequence caution: Sequence=BAB71618.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q53R38 Q53SP3 Q5GM69 Q8N6M1 Q96LQ2

Explore the universe of human proteins at neXtProt for SESTD1: NX_Q86VW0

Explore proteomics data for SESTD1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See SESTD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_835224.3

ENSEMBL proteins:

ENSP00000415332 ENSP00000410632 ENSP00000334183 ENSP00000391000 ENSP00000416164

ENSP00000410286 ENSP00000387517

SESTD1 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for SESTD1 OriGene Protein Over-expression Lysate for SESTD1 OriGene MassSpec for SESTD1 OriGene Custom Protein Services for SESTD1
	GenScript Custom Purified and Recombinant Proteins Services for SESTD1
	Novus Biologicals SESTD1 Proteins Novus Biologicals SESTD1 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for SESTD1

SESTD1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for SESTD1 OriGene Custom Antibody Services for SESTD1
	Novus Biologicals SESTD1 Antibodies
	Abcam antibodies for SESTD1
	Cloud-Clone Corp. Antibodies for SESTD1
	ThermoFisher Antibodies for SESTD1
	LSBio Antibodies in human, mouse, rat for SESTD1

SESTD1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SESTD1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SESTD1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SESTD1 Cloud-Clone Corp. CLIAs for SESTD1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:

IPR001251 CRAL-TRIO_dom

IPR018159 Spectrin/alpha-actinin

Graphical View of Domain Structure for InterPro Entry Q86VW0

ProtoNet protein and cluster: Q86VW0

1 Blocks protein domain: IPB002017 Spectrin repeat

UniProtKB/Swiss-Prot: SESD1_HUMAN, Q86VW0

Similarity: Belongs to the SOLO family

Similarity: Contains 1 CRAL-TRIO domain

Similarity: Contains 3 spectrin repeats

SESTD1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: SESD1_HUMAN, Q86VW0

Function: May act as the primary docking protein directing membrane turnover and assembly of the transient

receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates,

phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including

phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent.

Might be involved in the plasma membrane localization of CTNNB1

Gene Ontology (GO): Selected molecular function terms (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001786	NOT phosphatidylserine binding	IDA	--
GO:0005515	protein binding	IPI	--
GO:0005545	NOT 1-phosphatidylinositol binding	IDA	--
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IDA	--
GO:0010314	phosphatidylinositol-5-phosphate binding	IDA	--

SESTD1 for ontologies About GeneDecksing

Phenotypes:
5 GenomeRNAi human phenotypes for SESTD1:

Decreased p24 protein expressi	G0/1 arrest	Increased G1 DNA content	Increased cell size
Synthetic lethal with imatinib

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sestd1):

digestive/alimentary	embryogenesis	limbs/digits/tail	mortality/aging	nervous system
renal/urinary system	reproductive system

SESTD1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Sestd1^tm1.1Bnrc for SESTD1

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SESTD1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SESTD1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SESTD1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SESTD1

miRNA Products:		miRTarBase miRNAs that target SESTD1: hsa-mir-19b-3p (MIRT031094), hsa-mir-148b-3p (MIRT019309), hsa-mir-21-5p (MIRT030699), hsa-mir-130b-3p (MIRT020137), hsa-mir-148a-3p (MIRT026016)

		Block miRNA regulation of human, mouse, rat SESTD1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SESTD1 (see all 150):
		hsa-miR-3938 hsa-miR-361-5p hsa-miR-1224-3p hsa-miR-1260b hsa-miR-938 hsa-miR-3074-3p hsa-miR-3622b-3p hsa-miR-642b

		SwitchGear 3'UTR luciferase reporter plasmid: SESTD1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SESTD1
		Predesigned siRNA for gene silencing in human, mouse, rat SESTD1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SESTD1

Clone Products:		OriGene clones in human, mouse for SESTD1 (see all 6) OriGene ORF clones in mouse, rat for SESTD1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SESTD1 (NM_178123)
		Sino Biological Human cDNA Clone for SESTD1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SESTD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESTD1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SESTD1
		Browse ESI BIO Cell Lines and PureStem Progenitors for SESTD1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESTD1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	2
nucleus	2
endoplasmic reticulum	1

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Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0034704	colocalizes with calcium channel complex	IPI	--

SESTD1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for SESTD1
Interactions:

Search GeneGlobe Interaction Network for SESTD1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

Selected Interacting proteins for SESTD1 (Q86VW0^{2, 3} ENSP00000415332⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DAXX	Q9UER7³	I2D: score=2
ENSG00000206206	Q9UER7³	I2D: score=2
ENSG00000206279	Q9UER7³	I2D: score=2
ENSG00000227046	Q9UER7³	I2D: score=2
ENSG00000231617	Q9UER7³	I2D: score=2

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SESTD1 (SESD1)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SESTD1 gene:

NM_178123.4

Unigene Cluster for SESTD1:

SEC14 and spectrin domains 1

Hs.30977 [show with all ESTs]

Unigene Representative Sequence: NM_178123

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000428443(uc002unh.4 uc002uni.4) ENST00000446758 ENST00000335289

ENST00000426988 ENST00000489901 ENST00000440010 ENST00000435047 ENST00000486468

ENST00000452991

miRNA Products:		Block miRNA regulation of human, mouse, rat SESTD1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SESTD1 (see all 150):
		hsa-miR-3938 hsa-miR-361-5p hsa-miR-1224-3p hsa-miR-1260b hsa-miR-938 hsa-miR-3074-3p hsa-miR-3622b-3p hsa-miR-642b

		SwitchGear 3'UTR luciferase reporter plasmid: SESTD1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SESTD1
		Predesigned siRNA for gene silencing in human, mouse, rat SESTD1

Clone Products:		OriGene clones in human, mouse for SESTD1 (see all 6) OriGene ORF clones in mouse, rat for SESTD1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SESTD1 (NM_178123)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SESTD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESTD1

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SESTD1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SESTD1
		QuantiTect SYBR Green Assays in human, mouse, rat SESTD1
		QuantiFast Probe-based Assays in human, mouse, rat SESTD1

Additional mRNA sequence:

AK056075.1 AK096232.1 AY209190.1 BC029744.1 BC047578.1 BC053862.1 BC061918.1

10 DOTS entries:

DT.100746691 DT.95161122 DT.100777554 DT.40130743 DT.100777553 DT.120937289 DT.428630 DT.95210443

DT.95357485 DT.95126280

Selected AceView cDNA sequences (see all 105):

BU622168 BQ012480 BU608616 AW409611 AW236727 AA634254 AI246493 BX279671

BC053862 AI918846 BM679490 BX109488 BM968478 AI214831 AW137965 AA912984

C16477 AA912983 D82702 BM721062 AL122046 AA635062 BI438940 BU729284

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SESTD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTTCGAGGCT

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SESTD1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SESTD1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.30977

UniProtKB/Swiss-Prot: SESD1_HUMAN, Q86VW0

Tissue specificity: Broad expression. High expression in thalamus and brain. Significantly expressed in

vasculature

Custom PCR Arrays for SESTD1

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SESTD1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SESTD1
		QuantiTect SYBR Green Assays in human, mouse, rat SESTD1
		QuantiFast Probe-based Assays in human, mouse, rat SESTD1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESTD1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SESTD1 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sestd1^{1 , 5}	SEC14 and spectrin domains 1^{1, 5}	88.79(n)¹ 98.28(a)¹		2 (45.92 cM)⁵ 228071¹ NM_175465.6¹ NP_780674.1¹ 77180340⁵
chicken (Gallus gallus)	Aves	SESTD1¹	SEC14 and spectrin domains 1	85.73(n) 95.4(a)		424125 XM_004942695.1 XP_004942752.1
lizard (Anolis carolinensis)	Reptilia	SESTD1⁶	SEC14 and spectrin domains 1	94(a)	1 ↔ 1	GL343320.1(314276-400252)
African clawed frog (Xenopus laevis)	Amphibia	BQ732041.1²	--	78.72(n)		BQ732041.1
zebrafish (Danio rerio)	Actinopterygii	sol²	solo	74.45(n)		360133 AB096104.1
fruit fly (Drosophila melanogaster)	Insecta	CG15822¹	CG15822	39.44(n) 26.67(a)		38273 NM_139436.3 NP_647693.2
worm (Caenorhabditis elegans)	Secernentea	CELE_F55D12.2¹	CELE_F55D12.2	42.82(n) 28.11(a)		172558 NM_001263694.1 NP_001250623.1

ENSEMBL Gene Tree for SESTD1 (if available)
TreeFam Gene Tree for SESTD1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SESTD1 gene

5 SIMAP similar genes for SESTD1 using alignment to 9 protein entries: SESD1_HUMAN (see all proteins):

DKFZp434O0515 KALRN TRIO MCF2L MCF2L2

SESTD1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3217565^1,2	C	--	171850824(-)	`TATCT-/ATC T/TATCTGTTG`	1	--	int¹		1		CSA	2
rs61703699^1,2	C	--	179392628(+)	`AAAAA-/AAAAA /AAAAAATCCTT`	2	--	int¹ cds¹		1		NA	2
rs140597255^1,2		--	179965955(+)	`CAACTA/GTAGTC`	1	--	ds500¹		0	--	--	--	--
rs145721427^1,2		--	179965963(+)	`GTCCTC/TCTTCA`	1	--	ds500¹		0	--	--	--	--
rs145317862^1,2		--	179966090(+)	`TGGTAA/GGTCAG`	1	--	ds500¹		0	--	--	--	--
rs192014788^1,2		--	179966095(+)	`GGTCAA/GTTGTT`	1	--	ds500¹		0	--	--	--	--
rs149195104^1,2		--	179966138(+)	`TCTAGA/GTCATC`	1	--	ds500¹		0	--	--	--	--
rs184911940^1,2		--	179966155(+)	`TAGCTG/TGCATA`	1	--	ds500¹		0	--	--	--	--
rs189373462^1,2		--	179966189(+)	`GGACTA/GATTGC`	1	--	ds500¹		0	--	--	--	--
rs143371719^1,2		--	179966227(+)	`ATGTTC/TCCAGT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SESTD1 (179966419 - 180129517 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for SESTD1 (see all 25): About this table

Variant ID	Type	Subtype	PubMed ID
nsv436303	CNV	Deletion	17901297
nsv820485	CNV	Deletion	20802225
esv2422030	CNV	Deletion	20811451
esv2721197	CNV	Deletion	23290073
esv989936	CNV	Deletion	20482838
esv2513814	CNV	Deletion	19546169
esv2671077	CNV	Deletion	23128226
nsv3060	CNV	Loss	18451855
nsv3061	CNV	Loss	18451855
nsv511167	CNV	Loss	21212237

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SESTD1

DNA2.0 Custom Variant and Variant Library Synthesis for SESTD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases for SESTD1:
About MalaCards

hiv-1 malaria

SESTD1 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Genetic Association Database (GAD): SESTD1
Human Genome Epidemiology (HuGE) Navigator: SESTD1 (3 documents)

Export disorders for SESTD1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SESTD1 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with SESTD1)

Utopia: connect your pdf to the dynamic
world of online information

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PubMed id 20164195)^{1, 2} Miehe S....Strubing C. (J. Biol. Chem. 2010)
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)^{1, 4} Trynka G....Wijmenga C. (Gut 2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Representational difference analysis, high-resolution physical mapping, and transcript identification of the zebrafish genomic region for a motor behavior. (PubMed id 12837271)^{1, 3} Sato T. and Mishina M. (Genomics 2003)
Genome-wide association study of antiphospholipid antibodies. (PubMed id 23509613)¹ Kamboh M.I....Demirci F.Y. (Autoimmune Dis 2013)
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)¹ Li S.... Dorf M.E. (Immunity 2011)
Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)⁴ Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)¹ Brass A.L....Elledge S.J. (Science 2008)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W.... Wilson R.K. (Nature 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 91404	HGNC: 18379	AceView: SESTD1	Ensembl:ENSG00000187231	euGenes: HUgn91404
ECgene: SESTD1	H-InvDB: SESTD1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SESTD1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SESTD1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SESTD1 gene:
Search GeneIP for patents involving SESTD1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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SESTD1 Gene

SEC14 And Spectrin Domains 1

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SESTD1 Gene

SEC14 And Spectrin Domains 1

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