Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SESTD1 Gene

protein-coding GIFtS: 51
GCID: GC02M179966

SEC14 And Spectrin Domains 1

Search for SESTD1
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
SEC14 And Spectrin Domains 1¹ ²
Huntingtin-Interacting Protein-Like Protein² ³
Protein Solo² ³
SOLO² ³
SEC14 Domain And Spectrin Repeat-Containing Protein 1²

External Ids:	HGNC: 18379¹	Entrez Gene: 91404²	Ensembl: ENSG00000187231⁷	UniProtKB: Q86VW0³

Export aliases for SESTD1 gene to outside databases

Previous GC identifers: GC00U991235 GC02M180176 GC02M179799 GC02M179681 GC02M171835

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SESTD1 Gene:

SESTD1 (SEC14 and spectrin domains 1) is a protein-coding gene. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot: SESD1_HUMAN, Q86VW0

Function: May act as the primary docking protein directing membrane turnover and assembly of the transient receptor

potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates,

phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including

phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be

involved in the plasma membrane localization of CTNNB1

Gene Wiki entry for SESTD1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NT_005403.17 NC_018913.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SESTD1 gene promoter:
AML1a FOXO3 Meis-1b FOXO3b AREB6 FOXO4 FOXO3a POU2F1c Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SESTD1 promoter sequence

Search SABiosciences Chromatin IP Primers for SESTD1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SESTD1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.2 Ensembl cytogenetic band: 2q31.2 HGNC cytogenetic band: 2q31.3

SESTD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SESTD1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M179966: view genomic region (about GC identifiers)

Start:	179,966,419 bp from pter	End:	180,129,517 bp from pter
Size:	163,099 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SESD1_HUMAN, Q86VW0 (See protein sequence)

Recommended Name: SEC14 domain and spectrin repeat-containing protein 1

Size: 696 amino acids; 79348 Da

Subunit: Interacts (via the spectrin 1 repeat) with TRPC4 and TRPC5 (via CIRB domain). Interacts with CTNNB1

Miscellaneous: Called SOLO because the encoded protein is related to but shorter than DUO and TRIO

Sequence caution: Sequence=BAB71618.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q53R38 Q53SP3 Q5GM69 Q8N6M1 Q96LQ2

Explore the universe of human proteins at neXtProt for SESTD1: NX_Q86VW0

Explore proteomics data for SESTD1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q86VW0

SESTD1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_835224.3

ENSEMBL proteins:

ENSP00000415332 ENSP00000410632 ENSP00000334183 ENSP00000391000 ENSP00000416164

ENSP00000410286 ENSP00000387517

Human Recombinant Protein Products for SESTD1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for SESTD1 OriGene Protein Over-expression Lysate for SESTD1 OriGene MassSpec for SESTD1 OriGene Custom Protein Services for SESTD1
	GenScript Custom Purified and Recombinant Proteins Services for SESTD1
	Novus Biologicals SESTD1 Proteins Novus Biologicals SESTD1 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for SESTD1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0034704	colocalizes with calcium channel complex	IPI	--

SESTD1 for ontologies About GeneDecksing

SESTD1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for SESTD1 OriGene Custom Antibody Services for SESTD1
	GenScript Custom Superior Antibodies Services for SESTD1
	Novus Biologicals SESTD1 Antibodies
	Abcam antibodies for SESTD1
	Cloud-Clone Corp. Antibodies for SESTD1
	ThermoFisher Antibodies for SESTD1
	LSBio Antibodies in human, mouse, rat for SESTD1

Assay Products for SESTD1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SESTD1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SESTD1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SESTD1 Cloud-Clone Corp. CLIAs for SESTD1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro protein domains:

IPR001251 CRAL-TRIO_dom

IPR018159 Spectrin/alpha-actinin

Graphical View of Domain Structure for InterPro Entry Q86VW0

ProtoNet protein and cluster: Q86VW0

1 Blocks protein domain: IPB002017 Spectrin repeat

UniProtKB/Swiss-Prot: SESD1_HUMAN, Q86VW0

Similarity: Belongs to the SOLO family

Similarity: Contains 1 CRAL-TRIO domain

Similarity: Contains 3 spectrin repeats

SESTD1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SESD1_HUMAN, Q86VW0

Function: May act as the primary docking protein directing membrane turnover and assembly of the transient receptor

potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates,

phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including

phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be

involved in the plasma membrane localization of CTNNB1

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001786	NOT phosphatidylserine binding	IDA	--
GO:0005515	protein binding	IPI	--
GO:0005545	NOT 1-phosphatidylinositol binding	IDA	--
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IDA	--
GO:0010314	phosphatidylinositol-5-phosphate binding	IDA	--

SESTD1 for ontologies About GeneDecksing

Phenotypes:
5 GenomeRNAi human phenotypes for SESTD1:

Decreased p24 protein expressi	G0/1 arrest	Increased G1 DNA content	Increased cell size
Synthetic lethal with imatinib

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for SESTD1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SESTD1

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SESTD1
		8/150 QIAGEN miScript miRNA Assays for microRNAs that regulate SESTD1 (see all 150):
		hsa-miR-3938 hsa-miR-361-5p hsa-miR-1224-3p hsa-miR-1260b hsa-miR-938 hsa-miR-3074-3p hsa-miR-3622b-3p hsa-miR-642b

		SwitchGear 3'UTR luciferase reporter plasmid: SESTD1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SESTD1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SESTD1
		Sirion Biotech Custom design and validation of potent shRNA sequences against SESTD1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SESTD1
			Sirion Biotech Customized adenovirus for overexpression of SESTD1 Customized adenovirus for potent knockdown of SESTD1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for SESTD1 (see all 7) OriGene ORF clones in mouse, rat for SESTD1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SESTD1 (NM_178123)
		Sino Biological Human cDNA Clone for SESTD1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SESTD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESTD1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SESTD1
		Search LifeMap BioReagents cell lines for SESTD1
		Sirion Biotech Customized stable knockdown cell line services for SESTD1 Customized inducible knockdown cell line services for SESTD1 Customized stable overexpressing cell line services for SESTD1 Customized inducible overexpressing cell line services for SESTD1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESTD1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SESTD1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

5/10 Interacting proteins for SESTD1 (Q86VW0^{2, 3} ENSP00000415332⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DAXX	Q9UER7³	I2D: score=2
ENSG00000206206	Q9UER7³	I2D: score=2
ENSG00000206279	Q9UER7³	I2D: score=2
ENSG00000227046	Q9UER7³	I2D: score=2
ENSG00000231617	Q9UER7³	I2D: score=2

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SESTD1 (SESD1)

Search CenterWatch for drugs/clinical trials and news about SESTD1 / SESD1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SESTD1 gene:

NM_178123.4

Unigene Cluster for SESTD1:

SEC14 and spectrin domains 1

Hs.30977 [show with all ESTs]

Unigene Representative Sequence: NM_178123

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000428443(uc002unh.4 uc002uni.4) ENST00000446758 ENST00000335289

ENST00000426988 ENST00000489901 ENST00000440010 ENST00000435047 ENST00000486468

ENST00000452991

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SESTD1
		8/150 QIAGEN miScript miRNA Assays for microRNAs that regulate SESTD1 (see all 150):
		hsa-miR-3938 hsa-miR-361-5p hsa-miR-1224-3p hsa-miR-1260b hsa-miR-938 hsa-miR-3074-3p hsa-miR-3622b-3p hsa-miR-642b

		SwitchGear 3'UTR luciferase reporter plasmid: SESTD1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SESTD1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SESTD1
		Sirion Biotech Custom design and validation of potent shRNA sequences against SESTD1

Clone Products:		OriGene clones in human, mouse for SESTD1 (see all 7) OriGene ORF clones in mouse, rat for SESTD1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SESTD1 (NM_178123)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SESTD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESTD1

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SESTD1
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SESTD1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SESTD1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SESTD1

Additional mRNA sequence:

AK056075.1 AK096232.1 AY209190.1 BC029744.1 BC047578.1 BC053862.1 BC061918.1

10 DOTS entries:

DT.100746691 DT.95161122 DT.100777554 DT.40130743 DT.100777553 DT.120937289 DT.428630 DT.95210443

DT.95357485 DT.95126280

24/105 AceView cDNA sequences (see all 105):

BM703075 N34160 CD676524 AW137965 BX109488 AA634254 AI918846 BM968478

BU729284 BM679490 D82695 BI438940 AA635062 D82702 BU622168 AA912983

BX279671 AI246493 AA629517 AW409611 AI214831 AI281887 AK057944 BI438613

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SESTD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTTCGAGGCT

About this image

See SESTD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SESTD1

SOURCE GeneReport for Unigene cluster: Hs.30977

UniProtKB/Swiss-Prot: SESD1_HUMAN, Q86VW0

Tissue specificity: Broad expression. High expression in thalamus and brain. Significantly expressed in vasculature

SABiosciences Custom PCR Arrays for SESTD1

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SESTD1
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SESTD1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SESTD1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SESTD1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESTD1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SESTD1 gene from 7/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sestd1^{1 , 5}	SEC14 and spectrin domains 1^{1, 5}	88.79(n)¹ 98.28(a)¹		2 (45.92 cM)⁵ 228071¹ NM_175465.6¹ NP_780674.1¹ 77180340⁵
chicken (Gallus gallus)	Aves	SESTD1¹	SEC14 and spectrin domains 1	85.73(n) 95.4(a)		424125 XM_421978.3 XP_421978.1
lizard (Anolis carolinensis)	Reptilia	-- SESTD1⁶	Uncharacterized protein	94(a)	possible ortholog 1 ↔ 1	GL344614.1(950-10183) GL343320.1(314276-400252)
African clawed frog (Xenopus laevis)	Amphibia	BQ732041.1²	--	78.72(n)		BQ732041.1
zebrafish (Danio rerio)	Actinopterygii	sol²	solo	74.45(n)		360133 AB096104.1
fruit fly (Drosophila melanogaster)	Insecta	CG15822⁶ trio⁶	trio	9(a) 6(a)	possible ortholog 1 ↔ many	3L(2153201-2163863) 3L(995982-1034875)
worm (Caenorhabditis elegans)	Secernentea	CELE_F55D12.2¹	Protein F55D12.2	43.06(n) 27.94(a)		172558 NM_059778.4 NP_492179.2

ENSEMBL Gene Tree for SESTD1 (if available)
TreeFam Gene Tree for SESTD1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SESTD1 gene

5 SIMAP similar genes for SESTD1 using alignment to 9 protein entries: SESD1_HUMAN (see all proteins):

DKFZp434O0515 KALRN TRIO MCF2L MCF2L2

SESTD1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3217565^1,2	C	--	171850824(-)	`TATCT-/ATC T/TATCTGTTG`	1	--	int¹		1		CSA	2
rs61703699^1,2	C	--	179392628(+)	`AAAAA-/AAAAA /AAAAAATCCTT`	2	--	int¹ cds¹		1		NA	2
rs140597255^1,2		--	179965955(+)	`CAACTA/GTAGTC`	1	--	ds500¹		0	--	--	--	--
rs145721427^1,2		--	179965963(+)	`GTCCTC/TCTTCA`	1	--	ds500¹		0	--	--	--	--
rs145317862^1,2		--	179966090(+)	`TGGTAA/GGTCAG`	1	--	ds500¹		0	--	--	--	--
rs192014788^1,2		--	179966095(+)	`GGTCAA/GTTGTT`	1	--	ds500¹		0	--	--	--	--
rs149195104^1,2		--	179966138(+)	`TCTAGA/GTCATC`	1	--	ds500¹		0	--	--	--	--
rs184911940^1,2		--	179966155(+)	`TAGCTG/TGCATA`	1	--	ds500¹		0	--	--	--	--
rs189373462^1,2		--	179966189(+)	`GGACTA/GATTGC`	1	--	ds500¹		0	--	--	--	--
rs143371719^1,2		--	179966227(+)	`ATGTTC/TCCAGT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SESTD1 (179966419 - 180129517 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/25 variations for SESTD1 (see all 25): About this table

Variant ID	Type	Subtype	PubMed ID
nsv436303	CNV	Deletion	17901297
nsv820485	CNV	Deletion	20802225
esv2422030	CNV	Deletion	20811451
esv2721197	CNV	Deletion	23290073
esv989936	CNV	Deletion	20482838
esv2513814	CNV	Deletion	19546169
esv2671077	CNV	Deletion	23128226
nsv3060	CNV	Loss	18451855
nsv3061	CNV	Loss	18451855
nsv511167	CNV	Loss	21212237

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SESTD1

DNA2.0 Custom Variant and Variant Library Synthesis for SESTD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SESTD1 for disorders About MalaCards

SESTD1 for disorders About GeneDecksing

Genetic Association Database (GAD): SESTD1
Human Genome Epidemiology (HuGE) Navigator: SESTD1 (3 documents)

Export disorders for SESTD1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SESTD1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with SESTD1)

Utopia: connect your pdf to the dynamic
world of online information

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PubMed id 20164195)^{1, 2} Miehe S....Strubing C. (2010)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)^{1, 4} Trynka G....Wijmenga C. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Representational difference analysis, high-resolution physical mapping, and transcript identification of the zebrafish genomic region for a motor behavior. (PubMed id 12837271)^{1, 3} Sato T. and Mishina M. (2003)
Genome-wide association study of antiphospholipid anti bodies. (PubMed id 23509613)¹ Kamboh M.I....Demirci F.Y. (2013)
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)¹ Li S....Dorf M.E. (2011)
Genetic associations of variants in genes encoding HI V-dependency factors required for HIV-1 infection. (PubMed id 21083371)⁴ Chinn L.W....O'Brien S.J. (2010)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 91404	HGNC: 18379	AceView: SESTD1	Ensembl:ENSG00000187231	euGenes: HUgn91404
ECgene: SESTD1	H-InvDB: SESTD1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SESTD1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SESTD1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SESTD1 gene:
Search GeneIP for patents involving SESTD1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for SESTD1		OriGene RNAi products in human, mouse, rat for SESTD1
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for SESTD1
	OriGene MassSpec something-or-other for SESTD1		OriGene clones in human, mouse for SESTD1
	OriGene qSTAR qPCR primer pairs in human, mouse for SESTD1		OriGene Purified Protein for SESTD1
	OriGene ORF clones in mouse, rat for SESTD1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SESTD1		OriGene Custom Protein Services for SESTD1

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SESTD1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SESTD1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SESTD1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SESTD1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SESTD1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SESTD1

	GenScript Custom Purified and Recombinant Proteins Services for SESTD1		GenScript cDNA clones with any tag delivered in your preferred vector for SESTD1
	GenScript Custom Assay Services for SESTD1		GenScript Custom Superior Antibodies Services for SESTD1
	GenScript Custom overexpressing Cell Line Services for SESTD1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SESTD1 promoter
	Search Chromatin IP Primers for SESTD1
	RT² qPCR Primer Assay in human, mouse, rat SESTD1
	Search GNC Networks for SESTD1
	SABiosciences Custom PCR Arrays for SESTD1

Search Tocris compounds for SESTD1 (SESD1)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	cDNA Clones for SESTD1
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SESTD1 antibodies
	SESTD1 proteins
	SESTD1 lysates

	Antibodies for SESTD1
	See all of Abcam's Antibodies, Kits and Proteins for SESTD1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for SESTD1
	Antibodies for SESTD1
	ELISAs for SESTD1
	CLIAs for SESTD1

Search LifeMap BioReagents cell lines for SESTD1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESTD1

	SwitchGear 3'UTR luciferase reporter plasmids for SESTD1
	SwitchGear Promoter luciferase reporter plasmids for SESTD1

ThermoFisher Antibodies for SESTD1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESTD1

	inGenious Targeting Laboratory - Custom generated mouse model solutions for SESTD1
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SESTD1

Customized:

	stable knockdown cell line services for SESTD1
	inducible knockdown cell line services for SESTD1
	design and validation of potent shRNA sequences against SESTD1
	adenovirus for potent knockdown of SESTD1
	stable overexpressing cell line services for SESTD1
	inducible overexpressing cell line services for SESTD1
	adenovirus for overexpression of SESTD1

LSBio Antibodies in human, mouse, rat for SESTD1

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SESTD1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

SESTD1 Gene

SEC14 And Spectrin Domains 1

Aliases
for SESTD1 gene

Summaries
for SESTD1 gene

Genomic Views
for SESTD1 gene

Proteins
for SESTD1 gene

Protein Domains /
Families
for SESTD1 gene

Function
for SESTD1 gene

Pathways & Interactions
for SESTD1 gene

Drugs & Compounds
for SESTD1 gene

Transcripts
for SESTD1 gene

Expression
for SESTD1 gene

Orthologs
for SESTD1 gene

Paralogs
for SESTD1 gene

Genomic Variants
for SESTD1 gene

Disorders / Diseases
for SESTD1 gene

Publications
for SESTD1 gene

External Searches for SESTD1 gene

Genome Databases showing SESTD1 gene

Other Databases showing SESTD1 gene

Specialized Databases showing SESTD1 gene

Intellectual Property
for SESTD1 gene

Products
for SESTD1 gene

View Random Gene

Advanced Search

Export list of displayed genes

SESTD1 Gene

SEC14 And Spectrin Domains 1

Aliasesfor SESTD1 gene

Summariesfor SESTD1 gene

Genomic Viewsfor SESTD1 gene

Proteinsfor SESTD1 gene

Protein Domains /Familiesfor SESTD1 gene

Functionfor SESTD1 gene

Pathways & Interactionsfor SESTD1 gene

Drugs & Compoundsfor SESTD1 gene

Transcriptsfor SESTD1 gene

Expression for SESTD1 gene

Orthologsfor SESTD1 gene

Paralogsfor SESTD1 gene

Genomic Variantsfor SESTD1 gene

Disorders / Diseasesfor SESTD1 gene

Publicationsfor SESTD1 gene

External Searches for SESTD1 gene

Genome Databases showing SESTD1 gene

Other Databases showing SESTD1 gene

Specialized Databases showing SESTD1 gene

Intellectual Propertyfor SESTD1 gene

Productsfor SESTD1 gene

View Random Gene

Aliases
for SESTD1 gene

Summaries
for SESTD1 gene

Genomic Views
for SESTD1 gene

Proteins
for SESTD1 gene

Protein Domains /
Families
for SESTD1 gene

Function
for SESTD1 gene

Pathways & Interactions
for SESTD1 gene

Drugs & Compounds
for SESTD1 gene

Transcripts
for SESTD1 gene

Expression
for SESTD1 gene

Orthologs
for SESTD1 gene

Paralogs
for SESTD1 gene

Genomic Variants
for SESTD1 gene

Disorders / Diseases
for SESTD1 gene

Publications
for SESTD1 gene

Intellectual Property
for SESTD1 gene

Products
for SESTD1 gene