Aliases for SESTD1 Gene
Aliases for SESTD1 Gene
External Ids for SESTD1 Gene
- HGNC: 18379
- Entrez Gene: 91404
- Ensembl: ENSG00000187231
- UniProtKB: Q86VW0
Previous GeneCards Identifiers for SESTD1 Gene
- GC00U991235
- GC02M180176
- GC02M179799
- GC02M179681
- GC02M179966
- GC02M171835
Summaries for SESTD1 Gene
GeneCards Summary for SESTD1 Gene
SESTD1 (SEC14 And Spectrin Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and phosphatidylserine binding.
UniProtKB/Swiss-Prot for SESTD1 Gene
-
May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SESTD1 Gene
Genomics for SESTD1 Gene
Regulatory Elements for SESTD1 Gene
Enhancers for SESTD1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G179237 | 1.4 | Ensembl ENCODE dbSUPER | 19 | +25.8 | 25761 | 3.8 | ELF3 FEZF1 ZBTB40 RAD21 ZNF48 RARA FOS ETV6 CREM MIXL1 | SESTD1 TTN GC02P179234 |
| GH02G179234 | 1 | Ensembl ENCODE | 18.9 | +29.5 | 29509 | 1.8 | SOX13 ZBTB21 CEBPG ZNF384 RARA ZNF366 SCRT2 ZNF600 NR2F6 MAFK | SESTD1 GC02P179234 |
| GH02G179180 | 1 | FANTOM5 ENCODE | 17.3 | +84.1 | 84052 | 1.4 | SOX5 SOX13 TFAP4 TEAD4 CEBPB CEBPG ZNF623 HNF1A HDAC2 ATF3 | SESTD1 GC02P179150 GC02P179231 |
| GH02G179030 | 1.3 | FANTOM5 Ensembl ENCODE | 10.2 | +232.9 | 232934 | 2.2 | TBP TBL1XR1 RELA ARID3A POLR2A CBX5 EED ZSCAN29 RELB ETV6 | SESTD1 CCDC141 GC02P179029 |
| GH02G178892 | 1 | ENCODE dbSUPER | 10.8 | +373.2 | 373242 | 0.2 | BCOR CTCF PKNOX1 ZNF654 RFX1 TRIM22 ZMYM3 CEBPG REST RAD21 | SESTD1 GC02P178916 RNU7-104P |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SESTD1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for SESTD1 Gene
- Chromosome:
- 2
- Start:
- 179,101,692 bp from pter
- End:
- 179,264,790 bp from pter
- Size:
- 163,099 bases
- Orientation:
- Minus strand
Genomic View for SESTD1 Gene
Genes around SESTD1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q31.2 by Ensembl
- 2q31.2 by Entrez Gene
- 2q31.2 by HGNC
SESTD1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SESTD1 Gene
Proteins for SESTD1 Gene
-
Protein details for SESTD1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86VW0-SESD1_HUMAN
- Recommended name:
- SEC14 domain and spectrin repeat-containing protein 1
- Protein Accession:
- Q86VW0
- Q53R38
- Q53SP3
- Q5GM69
- Q8N6M1
- Q96LQ2
Protein attributes for SESTD1 Gene
- Size:
- 696 amino acids
- Molecular mass:
- 79348 Da
- Quaternary structure:
-
- Interacts (via the spectrin 1 repeat) with TRPC4 and TRPC5 (via CIRB domain). Interacts with CTNNB1.
- Miscellaneous:
-
- Called SOLO because the encoded protein is related to but shorter than DUO and TRIO.
- SequenceCaution:
-
- Sequence=BAB71618.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for SESTD1 Gene
Post-translational modifications for SESTD1 Gene
Other Protein References for SESTD1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SESTD1
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- TA505938AM
- TA505938BM
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- TA505938HM
- TA505938JM
- Invitrogen Antibodies for SESTD1
- antibodies-online Antibodies for SESTD1: See all 21
- GeneTex SESTD1 antibody for SESTD1
-
Custom Antibody ServicesProSci Antibodies for SESTD1
Protein Products
-
OriGene Purified Proteins for SESTD1
- Search Origene for MassSpec and Protein Over-expression Lysates for SESTD1
- Origene Custom Protein Services for SESTD1
- antibodies-online Proteins for SESTD1: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SESTD1
No data available for DME Specific Peptides for SESTD1 Gene
Domains & Families for SESTD1 Gene
Protein Domains for SESTD1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SESTD1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86VW0- Family:
-
- Belongs to the SOLO family.
No data available for Gene Families for SESTD1 Gene
Function for SESTD1 Gene
Molecular function for SESTD1 Gene
- UniProtKB/Swiss-Prot Function:
- May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001786 | NOT phosphatidylserine binding | IDA | 20164195 |
| GO:0005515 | protein binding | IPI | 20164195 |
| GO:0005545 | NOT 1-phosphatidylinositol binding | IDA | 20164195 |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | IDA | 20164195 |
| GO:0010314 | phosphatidylinositol-5-phosphate binding | IDA | 20164195 |
Phenotypes for SESTD1 Gene
- MGI mutant phenotypes for SESTD1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SESTD1:
Animal Models for SESTD1 Gene
- MGI Knock Outs for SESTD1:
-
- Sestd1 tm1.1Bnrc
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SESTD1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SESTD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SESTD1 gene
- Search ViGene Biosciences for SESTD1
CRISPR Products
-
OriGene CRISPR knockouts for SESTD1
-
Applied Biological Materials CRISPR for SESTD1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SESTD1
- GenScript: Design CRISPR guide RNA sequences for SESTD1
miRNA for SESTD1 Gene
- miRTarBase miRNAs that target SESTD1
-
- hsa-mir-148b-3p (MIRT019309)
- hsa-mir-130b-3p (MIRT020137)
- hsa-mir-148a-3p (MIRT026016)
- hsa-mir-21-5p (MIRT030699)
- hsa-mir-19b-3p (MIRT031094)
- hsa-mir-4523 (MIRT441527)
- hsa-mir-4422 (MIRT441529)
- hsa-mir-1276 (MIRT441530)
- hsa-mir-548e-5p (MIRT441531)
- hsa-mir-3151-5p (MIRT486763)
- hsa-mir-92a-2-5p (MIRT486764)
- hsa-mir-3165 (MIRT486765)
- hsa-mir-6880-5p (MIRT486766)
- hsa-mir-8071 (MIRT486767)
- hsa-mir-4483 (MIRT486768)
- hsa-mir-1293 (MIRT486769)
- hsa-mir-6756-5p (MIRT486770)
- hsa-mir-6766-5p (MIRT486771)
- hsa-mir-608 (MIRT486772)
- hsa-mir-4651 (MIRT486773)
- hsa-mir-7110-5p (MIRT486774)
- hsa-mir-6842-5p (MIRT486775)
- hsa-mir-6752-5p (MIRT486776)
- hsa-mir-6816-5p (MIRT486777)
- hsa-mir-3196 (MIRT486778)
- hsa-mir-3180-3p (MIRT486779)
- hsa-mir-3180 (MIRT486780)
- hsa-mir-6782-5p (MIRT486781)
- hsa-mir-6732-5p (MIRT486782)
- hsa-mir-3936 (MIRT486783)
- hsa-mir-548s (MIRT505674)
- hsa-mir-374b-5p (MIRT505675)
- hsa-mir-374a-5p (MIRT505676)
- hsa-mir-4524b-5p (MIRT505677)
- hsa-mir-4524a-5p (MIRT505678)
- hsa-mir-3926 (MIRT505679)
- hsa-mir-103b (MIRT505680)
- hsa-mir-646 (MIRT505681)
- hsa-mir-5197-5p (MIRT505682)
- hsa-mir-503-5p (MIRT505683)
- hsa-mir-6838-5p (MIRT505684)
- hsa-mir-195-5p (MIRT505685)
- hsa-mir-15a-5p (MIRT505686)
- hsa-mir-15b-5p (MIRT505687)
- hsa-mir-497-5p (MIRT505688)
- hsa-mir-16-5p (MIRT505689)
- hsa-mir-424-5p (MIRT505690)
- hsa-mir-552-5p (MIRT699719)
- hsa-mir-4652-3p (MIRT699720)
- hsa-mir-4528 (MIRT699721)
- hsa-mir-3150b-5p (MIRT699722)
- hsa-mir-3150a-5p (MIRT699723)
- hsa-mir-4668-5p (MIRT716473)
- hsa-mir-371a-5p (MIRT716474)
- hsa-mir-4668-3p (MIRT716475)
- hsa-mir-548c-3p (MIRT716477)
miRNA Products
- Search ViGene Biosciences for SESTD1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for SESTD1
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-
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Clone Products
-
OriGene ORF clones in human for SESTD1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- VectorBuilder custom plasmid, inducible vectors for SESTD1
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for SESTD1
-
ViGene Biosciences adenoviral particle packaged cDNA for SESTD1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SESTD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SESTD1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SESTD1 Gene
Localization for SESTD1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0034704 | colocalizes_with calcium channel complex | IPI | 20164195 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for SESTD1 Gene
Pathways & Interactions for SESTD1 Gene
No Data Available
Interacting Proteins for SESTD1 Gene
Selected Interacting proteins:
ENSP00000415332
Q86VW0-SESD1_HUMAN
for SESTD1 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1904878 | negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | IMP | 20164195 |
No data available for Pathways by source and SIGNOR curated interactions for SESTD1 Gene
Transcripts for SESTD1 Gene
mRNA/cDNA for SESTD1 Gene
- (5) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (105) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SESTD1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SESTD1
-
Applied Biological Materials CRISPR for SESTD1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SESTD1
- GenScript: Design CRISPR guide RNA sequences for SESTD1
miRNA Products
- Search ViGene Biosciences for SESTD1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for SESTD1
- Browse OriGene Inhibitory RNA Products For SESTD1
-
ViGene Biosciences ready-to-package AAV shRNAs for SESTD1 gene
Clone Products
-
OriGene ORF clones in human for SESTD1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SESTD1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SESTD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SESTD1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for SESTD1 Gene
This gene is overexpressed in Bone (15.9), Fetal Brain (15.7), Frontal cortex (9.8), and Bone marrow stromal cell (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SESTD1 Gene
NURSA nuclear receptor signaling pathways regulating expression of SESTD1 Gene:
SESTD1SOURCE GeneReport for Unigene cluster for SESTD1 Gene:
Hs.30977mRNA Expression by UniProt/SwissProt for SESTD1 Gene:
Q86VW0-SESD1_HUMAN
Tissue specificity:
Broad expression. High expression in thalamus and brain. Significantly expressed in vasculature.
Evidence on tissue expression from TISSUES for SESTD1 Gene
- Nervous system(4.7)
Primer Products
-
OriGene qPCR primer pairs for SESTD1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SESTD1 Gene
Orthologs for SESTD1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SESTD1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SESTD1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | SESTD1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SESTD1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Sestd1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Sestd1 34 |
|
||
| chicken (Gallus gallus) |
Aves | SESTD1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SESTD1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sestd1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | sestd1 34 35 |
|
||
| sol 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007560 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG15822 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | CELE_F55D12.2 34 |
|
||
| F55D12.2 35 |
|
OneToOne |
- Species where no ortholog for SESTD1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SESTD1 Gene
(5) SIMAP similar genes for SESTD1 Gene using alignment to 9 proteins:
No data available for Paralogs for SESTD1 Gene
Variants for SESTD1 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000016803 | -- | 179,130,259(+) | TTCAC(C/T)GATCA | intron-variant | |
| rs1000017777 | -- | 179,101,656(+) | GTATT(-/AA)AAAGA | downstream-variant-500B | |
| rs1000029501 | -- | 179,185,389(+) | CATAT(C/T)GTATA | intron-variant | |
| rs1000033542 | -- | 179,219,177(+) | GCTGC(C/T)ATTAG | intron-variant | |
| rs1000092106 | -- | 179,163,967(+) | AACCT(A/G)CCACT | intron-variant |
Residual Variation Intolerance Score:
8.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.71;
32.47% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SESTD1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SESTD1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SESTD1 Gene
Disorders for SESTD1 Gene
Relevant External Links for SESTD1
No disorders were found for SESTD1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SESTD1 Gene
Publications for SESTD1 Gene
- The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PMID: 20164195) Miehe S. … Strubing C. (J. Biol. Chem. 2010) 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Representational difference analysis, high-resolution physical mapping, and transcript identification of the zebrafish genomic region for a motor behavior. (PMID: 12837271) Sato T. … Mishina M. (Genomics 2003) 2 3 64
Products for SESTD1 Gene
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- Invitrogen Antibodies for SESTD1
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- antibodies-online Antibodies for SESTD1: See all 21
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- antibodies-online Proteins for SESTD1: See all 5
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- ViGene Biosciences adenoviral particle packaged cDNA for SESTD1 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for SESTD1 gene
- Search ViGene Biosciences for SESTD1
- Custom Antibody ServicesProSci Antibodies for SESTD1
- Search for SESTD1 Proteins at ProSci
- Horizon Cell Lines for SESTD1
- Cyagen custom Knockout/knockin (KOKI) mouse models for SESTD1
- VectorBuilder custom plasmid, inducible vectors for SESTD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SESTD1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SESTD1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio