SESTD1 Gene

Aliases
for SESTD1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC00U991235 GC02M180176 GC02M179799 GC02M179681 GC02M171835

Summaries
for SESTD1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for SESTD1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000002.11  NT_005403.18  NC_018913.2  

SwitchGear Promoter luciferase reporter plasmid: SESTD1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SESTD1

SESTD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M179966:  view genomic region     (about GC identifiers)

Proteins
for SESTD1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for SESTD1: NX_Q86VW0

Explore proteomics data for SESTD1 at MOPED

Post-translational modifications: 

SESTD1 Human Recombinant Protein Products:

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	Search GeneTex for Proteins for SESTD1
	antibodies-online proteins for SESTD1 (3 products)
	antibodies-online peptides for SESTD1

SESTD1 Antibody Products:

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	antibodies-online antibodies for SESTD1 (16 products)

SESTD1 Assay Products:

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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SESTD1 Cloud-Clone Corp. CLIAs for SESTD1
	Search eBioscience for ELISAs for SESTD1
	antibodies-online kits for SESTD1 (4 products)

Domains /
Families
for SESTD1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q86VW0

Find genes that share domains with SESTD1           About GenesLikeMe

Function
for SESTD1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

(inferred from 1 allele) (MGI details for Sestd1)

genOway: Develop your customized and physiologically relevant rodent model for SESTD1

miRNA Products:		miRTarBase miRNAs that target SESTD1: hsa-mir-19b-3p (MIRT031094), hsa-mir-148b-3p (MIRT019309), hsa-mir-21-5p (MIRT030699), hsa-mir-130b-3p (MIRT020137), hsa-mir-148a-3p (MIRT026016)
		Block miRNA regulation of human, mouse, rat SESTD1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SESTD1 (see all 150):
		hsa-miR-3938 hsa-miR-361-5p hsa-miR-1224-3p hsa-miR-1260b hsa-miR-938 hsa-miR-3074-3p hsa-miR-3622b-3p hsa-miR-642b
		SwitchGear 3'UTR luciferase reporter plasmid: SESTD1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SESTD1
		Predesigned siRNA for gene silencing in human, mouse, rat SESTD1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SESTD1

Clone Products:		OriGene clones in human, mouse for SESTD1 (see all 6) OriGene ORF clones in mouse, rat for SESTD1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SESTD1 (NM_178123)
		Sino Biological Human cDNA Clone for SESTD1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SESTD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESTD1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SESTD1
		Browse ESI BIO Cell Lines and PureStem Progenitors for SESTD1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESTD1

Localization
for SESTD1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	2
nucleus	2
endoplasmic reticulum	1

About this image

Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for SESTD1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for SESTD1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for SESTD1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for SESTD1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SESTD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTTCGAGGCT

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SESTD1
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SESTD1
		QuantiTect SYBR Green Assays in human, mouse, rat SESTD1
		QuantiFast Probe-based Assays in human, mouse, rat SESTD1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESTD1

Orthologs
for SESTD1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for SESTD1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for SESTD1 gene

5 SIMAP similar genes for SESTD1 using alignment to 9 protein entries:     SESD1_HUMAN (see all proteins):

DKFZp434O0515    KALRN    TRIO    MCF2L    MCF2L2

Find genes that share paralogs with SESTD1           About GenesLikeMe

Genomic Variants
for SESTD1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SESTD1 (see all 3268)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs32175651,2	C	--	171850824(-)	TATCT-/ATC      T/TATCTGTTG	1	--	int1		1		CSA	2
rs617036991,2	C	--	179392628(+)	AAAAA-/AAAAA   /AAAAAATCCTT	2	--	int1 cds1		1		NA	2
rs1405972551,2		--	179965955(+)	CAACTA/GTAGTC	1	--	ds5001		0	--	--	--	--
rs1457214271,2		--	179965963(+)	GTCCTC/TCTTCA	1	--	ds5001		0	--	--	--	--
rs1453178621,2		--	179966090(+)	TGGTAA/GGTCAG	1	--	ds5001		0	--	--	--	--
rs1920147881,2		--	179966095(+)	GGTCAA/GTTGTT	1	--	ds5001		0	--	--	--	--
rs1491951041,2		--	179966138(+)	TCTAGA/GTCATC	1	--	ds5001		0	--	--	--	--
rs1849119401,2		--	179966155(+)	TAGCTG/TGCATA	1	--	ds5001		0	--	--	--	--
rs1893734621,2		--	179966189(+)	GGACTA/GATTGC	1	--	ds5001		0	--	--	--	--
rs1433717191,2		--	179966227(+)	ATGTTC/TCCAGT	1	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for SESTD1 (179966419 - 180129517 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for SESTD1 (see all 25):    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv436303	CNV	Deletion	17901297
nsv820485	CNV	Deletion	20802225
esv2422030	CNV	Deletion	20811451
esv2721197	CNV	Deletion	23290073
esv989936	CNV	Deletion	20482838
esv2513814	CNV	Deletion	19546169
esv2671077	CNV	Deletion	23128226
nsv3060	CNV	Loss	18451855
nsv3061	CNV	Loss	18451855
nsv511167	CNV	Loss	21212237

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SESTD1

DNA2.0 Custom Variant and Variant Library Synthesis for SESTD1

Disorders / Diseases
for SESTD1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for SESTD1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SESTD1 gene, integrated from 10 sources (see all 13): (articles sorted by number of sources associating them with SESTD1)

Utopia: connect your pdf to the dynamic world of online information

1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
2. The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PubMed id 20164195)^{1, 2} Miehe S....Strubing C. (J. Biol. Chem. 2010)
3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)^{1, 4} Trynka G....Wijmenga C. (Gut 2009)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
5. Representational difference analysis, high-resolution physical mapping, and transcript identification of the zebrafish genomic region for a motor behavior. (PubMed id 12837271)^{1, 3} Sato T. and Mishina M. (Genomics 2003)
6. Genome-wide association study of antiphospholipid antibodies. (PubMed id 23509613)¹ Kamboh M.I....Demirci F.Y. (Autoimmune Dis 2013)
7. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)¹ Li S.... Dorf M.E. (Immunity 2011)
8. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)⁴ Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
9. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)¹ Brass A.L....Elledge S.J. (Science 2008)
10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W.... Wilson R.K. (Nature 2005)

External Searches for SESTD1 gene

Genome Databases showing SESTD1 gene

Other Databases showing SESTD1 gene

Specialized Databases showing SESTD1 gene

Products
for SESTD1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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