Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SESTD1 Gene

protein-coding   GIFtS: 51
GCID: GC02M179966

SEC14 And Spectrin Domains 1
  Search for SESTD1
at
MalaCards
 

Aliases
for SESTD1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
SEC14 And Spectrin Domains 11 2
Huntingtin-Interacting Protein-Like Protein2 3
Protein Solo2 3
SOLO2 3
SEC14 Domain And Spectrin Repeat-Containing Protein 12

External Ids:    HGNC: 183791   Entrez Gene: 914042   Ensembl: ENSG000001872317   UniProtKB: Q86VW03   

Export aliases for SESTD1 gene to outside databases

Previous GC identifers: GC00U991235 GC02M180176 GC02M179799 GC02M179681 GC02M171835


Summaries
for SESTD1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for SESTD1 Gene: 
SESTD1 (SEC14 and spectrin domains 1) is a protein-coding gene. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot: SESD1_HUMAN, Q86VW0
Function: May act as the primary docking protein directing membrane turnover and assembly of the transient
receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates,
phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including
phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent.
Might be involved in the plasma membrane localization of CTNNB1

Gene Wiki entry for SESTD1 Gene


Genomic Views
for SESTD1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SESTD1 gene promoter:
         AML1a   FOXO3   Meis-1b   FOXO3b   AREB6   FOXO4   FOXO3a   POU2F1c   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SESTD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SESTD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SESTD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.2   Ensembl cytogenetic band:  2q31.2   HGNC cytogenetic band: 2q31.3

SESTD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SESTD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M179966:  view genomic region     (about GC identifiers)

Start:
 179,966,419 bp from pter      End:
 180,129,517 bp from pter
Size:
 163,099 bases      Orientation:
 minus strand

Proteins
for SESTD1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: SESD1_HUMAN, Q86VW0 (See protein sequence)
Recommended Name: SEC14 domain and spectrin repeat-containing protein 1  
Size: 696 amino acids; 79348 Da
Subunit: Interacts (via the spectrin 1 repeat) with TRPC4 and TRPC5 (via CIRB domain). Interacts with CTNNB1
Miscellaneous: Called SOLO because the encoded protein is related to but shorter than DUO and TRIO
Sequence caution: Sequence=BAB71618.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q53R38 Q53SP3 Q5GM69 Q8N6M1 Q96LQ2

Explore the universe of human proteins at neXtProt for SESTD1: NX_Q86VW0

Explore proteomics data for SESTD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86VW0

    • SESTD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SESTD1 Protein Expression
    REFSEQ proteins: NP_835224.3  
    ENSEMBL proteins: 
     ENSP00000415332   ENSP00000410632   ENSP00000334183   ENSP00000391000   ENSP00000416164  
     ENSP00000410286   ENSP00000387517  

    Human Recombinant Protein Products for SESTD1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SESTD1
    OriGene Protein Over-expression Lysate for SESTD1
    OriGene MassSpec for SESTD1 
    OriGene Custom Protein Services for SESTD1
    GenScript Custom Purified and Recombinant Proteins Services for SESTD1
    Novus Biologicals SESTD1 Proteins
    Novus Biologicals SESTD1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SESTD1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034704colocalizes with calcium channel complex IPI--

    SESTD1 for ontologies           About GeneDecksing



    SESTD1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SESTD1
    OriGene Custom Antibody Services for SESTD1
    GenScript Custom Superior Antibodies Services for SESTD1
    Novus Biologicals SESTD1 Antibodies
    Abcam antibodies for SESTD1
    Cloud-Clone Corp. Antibodies for SESTD1 
    ThermoFisher Antibodies for SESTD1
    LSBio Antibodies in human, mouse, rat for SESTD1 

    Assay Products for SESTD1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SESTD1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SESTD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SESTD1 
    Cloud-Clone Corp. CLIAs for SESTD1

    Protein Domains /
    Families
    for SESTD1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 2 InterPro protein domains:
     IPR001251 CRAL-TRIO_dom
     IPR018159 Spectrin/alpha-actinin

    Graphical View of Domain Structure for InterPro Entry Q86VW0

    ProtoNet protein and cluster: Q86VW0

    1 Blocks protein domain: IPB002017 Spectrin repeat

    UniProtKB/Swiss-Prot: SESD1_HUMAN, Q86VW0
    Similarity: Belongs to the SOLO family
    Similarity: Contains 1 CRAL-TRIO domain
    Similarity: Contains 3 spectrin repeats


    SESTD1 for domains           About GeneDecksing


    Function
    for SESTD1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SESD1_HUMAN, Q86VW0
    Function: May act as the primary docking protein directing membrane turnover and assembly of the transient
    receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates,
    phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including
    phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent.
    Might be involved in the plasma membrane localization of CTNNB1

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001786NOT phosphatidylserine binding IDA--
    GO:0005515protein binding IPI--
    GO:0005545NOT 1-phosphatidylinositol binding IDA--
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding IDA--
    GO:0010314phosphatidylinositol-5-phosphate binding IDA--
         
    SESTD1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SESTD1:
     Decreased p24 protein expressi  G0/1 arrest  Increased G1 DNA content  Increased cell size 
     Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SESTD1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SESTD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SESTD1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SESTD1 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SESTD1
    8/150 QIAGEN miScript miRNA Assays for microRNAs that regulate SESTD1 (see all 150):
    hsa-miR-3938 hsa-miR-361-5p hsa-miR-1224-3p hsa-miR-1260b hsa-miR-938 hsa-miR-3074-3p hsa-miR-3622b-3p hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmid: SESTD1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SESTD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SESTD1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SESTD1
    Sirion Biotech Customized adenovirus for overexpression of SESTD1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SESTD1 (see all 7)
    OriGene ORF clones in mouse, rat for SESTD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SESTD1 (NM_178123)
    Sino Biological Human cDNA Clone for SESTD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SESTD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESTD1
    Sirion Biotech Customized lentivirus for stable overexpression of SESTD1 
                         Customized lentivirus expression plasmids for stable overexpression of SESTD1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SESTD1
    Search LifeMap BioReagents cell lines for SESTD1
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESTD1


    Pathways & Interactions
    for SESTD1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SESTD1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/10 Interacting proteins for SESTD1 (Q86VW02, 3 ENSP000004153324) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAXXQ9UER73I2D: score=2 
    ENSG00000206206Q9UER73I2D: score=2 
    ENSG00000206279Q9UER73I2D: score=2 
    ENSG00000227046Q9UER73I2D: score=2 
    ENSG00000231617Q9UER73I2D: score=2 
    About this table

    Drugs & Compounds
    for SESTD1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SESTD1 (SESD1)

    Search CenterWatch for drugs/clinical trials and news about SESTD1 / SESD1

    Transcripts
    for SESTD1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SESTD1 gene: 
    NM_178123.4  

    Unigene Cluster for SESTD1:

    SEC14 and spectrin domains 1
    Hs.30977  [show with all ESTs]
    Unigene Representative Sequence: NM_178123
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428443(uc002unh.4 uc002uni.4) ENST00000446758 ENST00000335289
    ENST00000426988 ENST00000489901 ENST00000440010 ENST00000435047 ENST00000486468
    ENST00000452991
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SESTD1
    8/150 QIAGEN miScript miRNA Assays for microRNAs that regulate SESTD1 (see all 150):
    hsa-miR-3938 hsa-miR-361-5p hsa-miR-1224-3p hsa-miR-1260b hsa-miR-938 hsa-miR-3074-3p hsa-miR-3622b-3p hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmid: SESTD1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SESTD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SESTD1
    Clone
    Products:             		 OriGene clones in human, mouse for SESTD1 (see all 7)
    OriGene ORF clones in mouse, rat for SESTD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SESTD1 (NM_178123)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SESTD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESTD1
    Sirion Biotech Customized lentivirus for stable overexpression of SESTD1 
                         Customized lentivirus expression plasmids for stable overexpression of SESTD1 
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for SESTD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SESTD1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SESTD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SESTD1

    Additional mRNA sequence: 

    AK056075.1 AK096232.1 AY209190.1 BC029744.1 BC047578.1 BC053862.1 BC061918.1 

    10 DOTS entries:

    DT.100746691  DT.95161122  DT.100777554  DT.40130743  DT.100777553  DT.120937289  DT.428630  DT.95210443 
    DT.95357485  DT.95126280 

    24/105 AceView cDNA sequences (see all 105):

    BM703075 N34160 CD676524 AW137965 BX109488 AA634254 AI918846 BM968478 
    BU729284 BM679490 D82695 BI438940 AA635062 D82702 BU622168 AA912983 
    BX279671 AI246493 AA629517 AW409611 AI214831 AI281887 AK057944 BI438613 

    GeneLoc Exon Structure


    Expression
    for SESTD1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SESTD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCGAGGCT
    SESTD1 Expression
    About this image


    See SESTD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SESTD1

    SOURCE GeneReport for Unigene cluster: Hs.30977

    UniProtKB/Swiss-Prot: SESD1_HUMAN, Q86VW0
    Tissue specificity: Broad expression. High expression in thalamus and brain. Significantly expressed in
    vasculature

        SABiosciences Custom PCR Arrays for SESTD1
    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for SESTD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SESTD1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SESTD1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SESTD1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESTD1

    Orthologs
    for SESTD1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SESTD1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sestd11 , 5 SEC14 and spectrin domains 11, 5 88.79(n)1
    98.28(a)1    		   2 (45.92 cM)5
    2280711  NM_175465.61  NP_780674.11 
     771803405 
    chicken
    (Gallus gallus)    		 Aves SESTD11 SEC14 and spectrin domains 1 85.73(n)
    95.4(a)    		   424125  XM_421978.3  XP_421978.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    SESTD16
    		 Uncharacterized protein
    94(a)
    		 possible ortholog
    1 ↔ 1
    		 GL344614.1(950-10183)
    GL343320.1(314276-400252)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BQ732041.12   -- 78.72(n)    BQ732041.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sol2 solo 74.45(n)   360133  AB096104.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG158226
    trio6
    		 trio
    		 9(a)
    6(a)
    		 possible ortholog
    1 ↔ many
    		 3L(2153201-2163863)
    3L(995982-1034875)
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_F55D12.21 Protein F55D12.2 43.06(n)
    27.94(a)    		   172558  NM_059778.4  NP_492179.2 


    ENSEMBL Gene Tree for SESTD1 (if available)
    TreeFam Gene Tree for SESTD1 (if available)

    Paralogs
    for SESTD1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SESTD1 gene
    5 SIMAP similar genes for SESTD1 using alignment to 9 protein entries:     SESD1_HUMAN (see all proteins):
    DKFZp434O0515    KALRN    TRIO    MCF2L    MCF2L2

    SESTD1 for paralogs           About GeneDecksing



    Genomic Variants
    for SESTD1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3268 SNPs in SESTD1 are shown (see all 3268)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs32175651,2
    		C--171850824(-) TATCT-/ATC   
      T    /TATC    TGTTG     		1 -- int11CSA 2
    rs617036991,2
    		C--179392628(+) AAAAA-/AAAAA 
         /AAAAAA    TCCTT     		2 -- int1 cds11NA 2
    rs1405972551,2
    		--179965955(+) CAACTA/GTAGTC 1 -- ds50010--------
    rs1457214271,2
    		--179965963(+) GTCCTC/TCTTCA 1 -- ds50010--------
    rs1453178621,2
    		--179966090(+) TGGTAA/GGTCAG 1 -- ds50010--------
    rs1920147881,2
    		--179966095(+) GGTCAA/GTTGTT 1 -- ds50010--------
    rs1491951041,2
    		--179966138(+) TCTAGA/GTCATC 1 -- ds50010--------
    rs1849119401,2
    		--179966155(+) TAGCTG/TGCATA 1 -- ds50010--------
    rs1893734621,2
    		--179966189(+) GGACTA/GATTGC 1 -- ds50010--------
    rs1433717191,2
    		--179966227(+) ATGTTC/TCCAGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SESTD1 (179966419 - 180129517 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for SESTD1 (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv436303CNV Deletion17901297
    nsv820485CNV Deletion20802225
    esv2422030CNV Deletion20811451
    esv2721197CNV Deletion23290073
    esv989936CNV Deletion20482838
    esv2513814CNV Deletion19546169
    esv2671077CNV Deletion23128226
    nsv3060CNV Loss18451855
    nsv3061CNV Loss18451855
    nsv511167CNV Loss21212237

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SESTD1
    DNA2.0 Custom Variant and Variant Library Synthesis for SESTD1

    Disorders / Diseases
    for SESTD1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SESTD1 for disorders           About MalaCards

    SESTD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SESTD1
    Human Genome Epidemiology (HuGE) Navigator: SESTD1 (3 documents)

    Export disorders for SESTD1 gene to outside databases

    Publications
    for SESTD1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SESTD1 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with SESTD1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PubMed id 20164195)1, 2 Miehe S....Strubing C. (2010)
    3. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Representational difference analysis, high-resolution physical mapping, and transcript identification of the zebrafish genomic region for a motor behavior. (PubMed id 12837271)1, 3 Sato T. and Mishina M. (2003)
    6. Genome-wide association study of antiphospholipid anti bodies. (PubMed id 23509613)1 Kamboh M.I....Demirci F.Y. (2013)
    7. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    8. Genetic associations of variants in genes encoding HI V-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (2010)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for SESTD1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SESTD1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91404 HGNC: 18379 AceView: SESTD1 Ensembl:ENSG00000187231 euGenes: HUgn91404
    ECgene: SESTD1 H-InvDB: SESTD1

    Other Databases showing SESTD1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SESTD1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SESTD1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SESTD1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SESTD1 gene:
    Search GeneIP for patents involving SESTD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SESTD1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SESTD1   OriGene RNAi products in human, mouse, rat for SESTD1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SESTD1  
     OriGene MassSpec something-or-other for SESTD1   OriGene clones in human, mouse for SESTD1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SESTD1   OriGene Purified Protein for SESTD1  
     OriGene ORF clones in mouse, rat for SESTD1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SESTD1   OriGene Custom Protein Services for SESTD1  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SESTD1
     QIAGEN SeqTarget long-range PCR primers for resequencing SESTD1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SESTD1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SESTD1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SESTD1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SESTD1
     GenScript Custom Purified and Recombinant Proteins Services for SESTD1 GenScript cDNA clones with any tag delivered in your preferred vector for SESTD1
     GenScript Custom Assay Services for SESTD1 GenScript Custom Superior Antibodies Services for SESTD1
     GenScript Custom overexpressing Cell Line Services for SESTD1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SESTD1 promoter
     Search Chromatin IP Primers for SESTD1
     RT2 qPCR Primer Assay in human, mouse, rat SESTD1
     Search GNC Networks for SESTD1
     SABiosciences Custom PCR Arrays for SESTD1
     Search Tocris compounds for SESTD1 (SESD1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SESTD1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SESTD1 antibodies
     SESTD1 proteins
     SESTD1 lysates
     Antibodies for SESTD1
     See all of Abcam's Antibodies, Kits and Proteins for SESTD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SESTD1
     Antibodies for SESTD1
     ELISAs for SESTD1
     CLIAs for SESTD1
     Search LifeMap BioReagents cell lines for SESTD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESTD1
     SwitchGear 3'UTR luciferase reporter plasmids for SESTD1
     SwitchGear Promoter luciferase reporter plasmids for SESTD1
     ThermoFisher Antibodies for SESTD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESTD1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SESTD1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SESTD1
    Customized:
     lentivirus for stable overexpression of SESTD1
     lentivirus expression plasmids for stable overexpression of SESTD1
     adenovirus for overexpression of SESTD1
     LSBio Antibodies in human, mouse, rat for SESTD1
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SESTD1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4