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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SESN3 Gene

protein-coding   GIFtS: 55
GCID: GC11M094906

Sestrin 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sestrin 31 2
SEST32 3 5
sestrin-32

External Ids:    HGNC: 230601   Entrez Gene: 1436862   Ensembl: ENSG000001492127   OMIM: 6077685   UniProtKB: P580053   

Export aliases for SESN3 gene to outside databases

Previous GC identifers: GC11M095090 GC11M094594 GC11M094545 GC11M090971


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SESN3 Gene:
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the
levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha
serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal
regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Oct 2012)

GeneCards Summary for SESN3 Gene: 
SESN3 (sestrin 3) is a protein-coding gene. Diseases associated with SESN3 include insulin resistance, and obesity, and among its related super-pathways are DNA damage response. An important paralog of this gene is SESN1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SESN3 gene promoter:
         USF1   SREBP-1c   NF-YA   NF-YB   CBF-A   CBF-B   USF-1   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSESN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SESN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SESN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21   Ensembl cytogenetic band:  11q21   HGNC cytogenetic band: 11q21

SESN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SESN3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M094906:  view genomic region     (about GC identifiers)

Start:
94,898,704 bp from pter      End:
94,965,705 bp from pter
Size:
67,002 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SESN3_HUMAN, P58005 (See protein sequence)
Recommended Name: Sestrin-3  
Size: 492 amino acids; 57291 Da
Caution: Positions 27 to 191 are in EST BF328700; positions 244 to 492 can be found in EST BG291497 but several
frameshifts need to be corrected to restore the correct sequence. Positions 412 to 492 are in AF086251 with no
conflicts
Secondary accessions: Q96AD1
Alternative splicing: 3 isoforms:  P58005-1   P58005-2   P58005-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SESN3: NX_P58005

Explore proteomics data for SESN3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P58005

  • SESN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SESN3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001258523.1  NP_653266.2  

    ENSEMBL proteins: 
     ENSP00000441927   ENSP00000278499   ENSP00000407008   ENSP00000439580   ENSP00000376926  

    Human Recombinant Protein Products for SESN3: 
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    Novus Biologicals SESN3 Proteins
    Novus Biologicals SESN3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SESN3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    SESN3 for ontologies           About GeneDecksing



    SESN3 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for SESN3 
    Cloud-Clone Corp. CLIAs for SESN3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006730 PA26

    Graphical View of Domain Structure for InterPro Entry P58005

    ProtoNet protein and cluster: P58005

    1 Blocks protein domain: IPB006730 PA26 p53-induced protein (sestrin)

    UniProtKB/Swiss-Prot: SESN3_HUMAN, P58005
    Similarity: Belongs to the sestrin family


    SESN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sesn3):
     behavior/neurological  growth/size  homeostasis/metabolism  liver/biliary system 

    SESN3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SESN3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SESN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SESN3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SESN3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SESN3
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SESN3 (see all 10):
    hsa-miR-4317 hsa-miR-92a hsa-miR-4268 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-514 hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmidSESN3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of SESN3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESN3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SESN3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    p53 signaling pathway0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for SESN3):
        p53 signaling pathway


    SESN3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SESN3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/6 Interacting proteins for SESN3 (P580053 ENSP000002784994) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206379O759553I2D: score=3 
    ENSG00000206480O759553I2D: score=3 
    ENSG00000230143O759553I2D: score=3 
    ENSG00000232280O759553I2D: score=3 
    FLOT1O759553I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007050cell cycle arrest IEA--

    SESN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SESN3

    Search CenterWatch for drugs/clinical trials and news about SESN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SESN3 gene (2 alternative transcripts): 
    NM_001271594.1  NM_144665.3  

    Unigene Cluster for SESN3:

    Sestrin 3
    Hs.120633  [show with all ESTs]
    Unigene Representative Sequence: NM_144665
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536441(uc001pfk.1) ENST00000278499(uc010rug.1) ENST00000416495(uc001pfl.3)
    ENST00000542176 ENST00000537480 ENST00000393234
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SESN3
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SESN3 (see all 10):
    hsa-miR-4317 hsa-miR-92a hsa-miR-4268 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-514 hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmidSESN3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SESN3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SESN3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESN3
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                         Customized lentivirus expression plasmids for stable overexpression of SESN3 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SESN3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SESN3

    Additional mRNA sequence: 

    AB072894.1 AF086251.1 AF086504.1 AK091132.1 AK096300.1 AK302366.1 AL832673.1 BC013939.1 
    BC017296.2 BC045700.1 BX649128.1 

    15 DOTS entries:

    DT.119784  DT.101974330  DT.95253550  DT.309177  DT.91917292  DT.120700737  DT.120700770  DT.100814636 
    DT.120700798  DT.100814639  DT.91850014  DT.91872509  DT.95126139  DT.120700800  DT.99980189 

    24/305 AceView cDNA sequences (see all 305):

    Z39807 AA707807 AI383586 BG261007 Z42328 BM696959 BX499854 BI962893 
    AI377592 BC017296 AW089590 BM454331 AW440825 AI888087 CA943604 AA452120 
    CK903926 CA843411 BU161785 BE221848 AL707857 AA926941 BM984875 BM052986 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SESN3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                    -     -                                                                           
    SP2:              -     -                                                                                 
    SP3:              -     -     -                                                                           
    SP4:                          -                                                                           


    ECgene alternative splicing isoforms for SESN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SESN3 expression in normal human tissues (normalized intensities)      SESN3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCTGGCGT
    SESN3 Expression
    About this image


    SESN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Endothelium (Cardiovascular System)
             Human corneal endothelial cells
     
     Eye (Sensory Organs)
             Human corneal endothelial cells
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   
     
     Testis (Reproductive System)

    See SESN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SESN3

    SOURCE GeneReport for Unigene cluster: Hs.120633

    UniProtKB/Swiss-Prot: SESN3_HUMAN, P58005
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for SESN3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SESN3 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sesn31 , 5 sestrin 31, 5 88.48(n)1
    93.9(a)1
      9 (3.89 cM)5
    757471  NM_030261.41  NP_084537.21 
     142763015 
    chicken
    (Gallus gallus)
    Aves SESN31 sestrin 3 84.38(n)
    92.19(a)
      428089  XM_425647.3  XP_425647.3 
    lizard
    (Anolis carolinensis)
    Reptilia SESN36
    Uncharacterized protein
    87(a)
    1 ↔ 1
    3(195525628-195540762)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.123442 Xenopus laevis transcribed sequence with moderate similarity to protein spP58005 (H.sapiens) SES3_HUMAN Sestrin 3 less 82.83(n)    BJ074225.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.51292 Danio rerio cDNA clone MGC56722 IMAGE2601412, complete cds less 73.07(n)    BC045518.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sesn1 Sestrin 54.69(n)
    51.1(a)
      37755  NM_137977.3  NP_611821.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sesn-11 Protein SESN-1 45.68(n)
    31.35(a)
      171593  NM_058263.3  NP_490664.2 


    ENSEMBL Gene Tree for SESN3 (if available)
    TreeFam Gene Tree for SESN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SESN3 gene
    SESN12  SESN22  
    2 SIMAP similar genes for SESN3 using alignment to 3 protein entries:     SESN3_HUMAN (see all proteins):
    SESN1    SESN2

    SESN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1040 SNPs in SESN3 are shown (see all 1040)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710363791,2
    C--91005893(-) CTGCT-/ATTAA 
            
    ATTAT
    2 -- int11Minor allele frequency- ATTAA:0.00NA 2
    rs1900207851,2
    --94898177(+) CATTCA/CAGCTC 2 -- ds50010--------
    rs1489005071,2
    --94898213(+) CATGAA/GTACAC 2 -- ds50010--------
    rs1811536801,2
    --94898223(+) CATCAC/GCTAAT 2 -- ds50010--------
    rs1175910531,2
    F--94898240(+) CCATCT/GCAAGA 2 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1851950011,2
    --94898313(+) AAGGTC/TGCAAA 2 -- ds50010--------
    rs1469957671,2
    --94898548(+) GTGAGA/TGATAA 2 -- ds50010--------
    rs1381159291,2
    --94898572(+) GAAACG/TGGGTC 2 -- ds50010--------
    rs1128858221,2
    F--94898994(+) CTAGAC/ATATTA 2 -- ut311Minor allele frequency- A:0.50CSA 2
    rs618936951,2
    C,F--94899042(+) ACTGTA/GAAATC 2 -- ut312Minor allele frequency- G:0.04NA 122

    HapMap Linkage Disequilibrium report for SESN3 (94898704 - 94965705 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SESN3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv989063CNV Deletion20482838
    esv2677596CNV Deletion23128226
    nsv447CNV Loss18451855
    esv994857CNV Loss20482838

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SESN3
    DNA2.0 Custom Variant and Variant Library Synthesis for SESN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607768    OMIM disorders: --

    2 diseases for SESN3:    About MalaCards
    insulin resistance    obesity


    SESN3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SESN3
    Human Genome Epidemiology (HuGE) Navigator: SESN3 (1 document)

    Export disorders for SESN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SESN3 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with SESN3)
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    1. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. (PubMed id 12607115)1, 2, 3 Peeters H.... Devriendt K. (2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability. (PubMed id 17510393)1, 9 Kopnin P.B....Chumakov P.M. (2007)
    6. Ras-induced ROS upregulation affecting cell proliferat ion is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways. (PubMed id 23388456)1 Zamkova M....Kopnin P. (2013)
    7. Maintenance of metabolic homeostasis by Sestrin2 and S estrin3. (PubMed id 22958918)1 Lee J.H....Karin M. (2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3. (PubMed id 22349704)1 Hagenbuchner J....Ausserlechner M.J. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 143686 HGNC: 23060 AceView: SESN3 Ensembl:ENSG00000149212 euGenes: HUgn143686
    ECgene: SESN3 Kegg: 143686 H-InvDB: SESN3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SESN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SESN3 gene:
    Search GeneIP for patents involving SESN3

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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