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Aliases for SESN3 Gene

Aliases for SESN3 Gene

  • Sestrin 3 2 3 5
  • SEST3 3 4

External Ids for SESN3 Gene

Previous GeneCards Identifiers for SESN3 Gene

  • GC11M095090
  • GC11M094594
  • GC11M094545
  • GC11M094906
  • GC11M090971

Summaries for SESN3 Gene

Entrez Gene Summary for SESN3 Gene

  • This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

GeneCards Summary for SESN3 Gene

SESN3 (Sestrin 3) is a Protein Coding gene. Among its related pathways are Gene Expression and Longevity regulating pathway - multiple species. An important paralog of this gene is SESN2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SESN3 Gene

Genomics for SESN3 Gene

Regulatory Elements for SESN3 Gene

Promoters for SESN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SESN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SESN3 Gene

Chromosome:
11
Start:
95,165,513 bp from pter
End:
95,232,541 bp from pter
Size:
67,029 bases
Orientation:
Minus strand

Genomic View for SESN3 Gene

Genes around SESN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SESN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SESN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SESN3 Gene

Proteins for SESN3 Gene

  • Protein details for SESN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58005-SESN3_HUMAN
    Recommended name:
    Sestrin-3
    Protein Accession:
    P58005
    Secondary Accessions:
    • B7Z7P9
    • Q96AD1

    Protein attributes for SESN3 Gene

    Size:
    492 amino acids
    Molecular mass:
    57291 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SESN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SESN3 Gene

Proteomics data for SESN3 Gene at MOPED

Post-translational modifications for SESN3 Gene

  • Ubiquitination at Lys 378
  • Modification sites at PhosphoSitePlus

Other Protein References for SESN3 Gene

No data available for DME Specific Peptides for SESN3 Gene

Domains & Families for SESN3 Gene

Protein Domains for SESN3 Gene

Suggested Antigen Peptide Sequences for SESN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P58005

UniProtKB/Swiss-Prot:

SESN3_HUMAN :
  • Belongs to the sestrin family.
Family:
  • Belongs to the sestrin family.
genes like me logo Genes that share domains with SESN3: view

No data available for Gene Families for SESN3 Gene

Function for SESN3 Gene

genes like me logo Genes that share phenotypes with SESN3: view

Animal Models for SESN3 Gene

MGI Knock Outs for SESN3:

Animal Model Products

miRNA for SESN3 Gene

miRTarBase miRNAs that target SESN3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SESN3 Gene

Localization for SESN3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SESN3 Gene COMPARTMENTS Subcellular localization image for SESN3 gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SESN3 Gene

Pathways & Interactions for SESN3 Gene

genes like me logo Genes that share pathways with SESN3: view

Pathways by source for SESN3 Gene

Interacting Proteins for SESN3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000441927%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000356480%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: P58005-SESN3_HUMAN ENSP00000441927 for SESN3 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SESN3 Gene

None

No data available for SIGNOR curated interactions for SESN3 Gene

Drugs & Compounds for SESN3 Gene

No Compound Related Data Available

Transcripts for SESN3 Gene

Unigene Clusters for SESN3 Gene

Sestrin 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SESN3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for SESN3 Gene

GeneLoc Exon Structure for
SESN3
ECgene alternative splicing isoforms for
SESN3

Expression for SESN3 Gene

mRNA expression in normal human tissues for SESN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SESN3 Gene

This gene is overexpressed in Liver, secretome (49.9) and Gallbladder (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SESN3 Gene



SOURCE GeneReport for Unigene cluster for SESN3 Gene Hs.120633

mRNA Expression by UniProt/SwissProt for SESN3 Gene

P58005-SESN3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SESN3: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SESN3 Gene

Orthologs for SESN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SESN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SESN3 35
  • 94.04 (n)
  • 98.79 (a)
SESN3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SESN3 35
  • 94.85 (n)
  • 98.37 (a)
SESN3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sesn3 35
  • 88.48 (n)
  • 93.9 (a)
Sesn3 16
Sesn3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SESN3 35
  • 99.12 (n)
  • 98.91 (a)
SESN3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sesn3 35
  • 87.53 (n)
  • 94.51 (a)
oppossum
(Monodelphis domestica)
Mammalia SESN3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SESN3 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves SESN3 35
  • 84.43 (n)
  • 92.76 (a)
SESN3 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SESN3 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sesn3 35
  • 75.9 (n)
  • 81.46 (a)
Str.2876 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12344 35
zebrafish
(Danio rerio)
Actinopterygii Dr.5129 35
sesn3 35
  • 67.18 (n)
  • 69.58 (a)
sesn3 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007169 35
  • 52.67 (n)
  • 52.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sesn 35
  • 54.79 (n)
  • 51.84 (a)
Sesn 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sesn-1 35
  • 45.84 (n)
  • 31.51 (a)
sesn-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3472 36
  • 30 (a)
OneToMany
Species with no ortholog for SESN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SESN3 Gene

ENSEMBL:
Gene Tree for SESN3 (if available)
TreeFam:
Gene Tree for SESN3 (if available)

Paralogs for SESN3 Gene

Paralogs for SESN3 Gene

(2) SIMAP similar genes for SESN3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SESN3: view

Variants for SESN3 Gene

Sequence variations from dbSNP and Humsavar for SESN3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10160385 - 95,191,535(+) CAGAC(A/G)ACCGG reference, missense, utr-variant-5-prime
rs11021069 - 95,185,338(+) CTGAT(A/G)TTAGC reference, missense
rs497751 -- 95,193,233(-) ATACC(A/T)GATCA intron-variant
rs520287 -- 95,166,371(+) ATAAT(C/T)CTGTA utr-variant-3-prime
rs481057 -- 95,184,051(+) AAAAA(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SESN3 Gene

Variant ID Type Subtype PubMed ID
nsv447 CNV Loss 18451855
esv989063 CNV Deletion 20482838
esv994857 CNV Loss 20482838
esv2677596 CNV Deletion 23128226

Variation tolerance for SESN3 Gene

Residual Variation Intolerance Score: 22.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SESN3 Gene

HapMap Linkage Disequilibrium report
SESN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SESN3 Gene

Disorders for SESN3 Gene

Relevant External Links for SESN3

Genetic Association Database (GAD)
SESN3
Human Genome Epidemiology (HuGE) Navigator
SESN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SESN3

No disorders were found for SESN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SESN3 Gene

Publications for SESN3 Gene

  1. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. (PMID: 12607115) Peeters H. … Devriendt K. (Hum. Genet. 2003) 2 3 4 67
  2. Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability. (PMID: 17510393) Kopnin P.B. … Chumakov P.M. (Cancer Res. 2007) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury. (PMID: 24833709) Kang X. … Liangpunsakul S. (Am. J. Physiol. Gastrointest. Liver Physiol. 2014) 3

Products for SESN3 Gene

Sources for SESN3 Gene

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