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SESN3 Gene

protein-coding   GIFtS: 56
GCID: GC11M094906

Sestrin 3

  See SESN3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sestrin 31 2
SEST32 3 5
sestrin-32

External Ids:    HGNC: 230601   Entrez Gene: 1436862   Ensembl: ENSG000001492127   OMIM: 6077685   UniProtKB: P580053   

Export aliases for SESN3 gene to outside databases

Previous GC identifers: GC11M095090 GC11M094594 GC11M094545 GC11M090971


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SESN3 Gene:
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the
levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha
serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal
regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Oct 2012)

GeneCards Summary for SESN3 Gene:
SESN3 (sestrin 3) is a protein-coding gene. Diseases associated with SESN3 include insulin resistance, and obesity. An important paralog of this gene is SESN1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the SESN3 gene promoter:
         USF1   SREBP-1c   NF-YA   NF-YB   CBF-A   CBF-B   USF-1   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSESN3 promoter sequence
   Search Chromatin IP Primers for SESN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SESN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21   Ensembl cytogenetic band:  11q21   HGNC cytogenetic band: 11q21

SESN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SESN3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M094906:  view genomic region     (about GC identifiers)

Start:
94,898,704 bp from pter      End:
94,965,705 bp from pter
Size:
67,002 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SESN3_HUMAN, P58005 (See protein sequence)
Recommended Name: Sestrin-3  
Size: 492 amino acids; 57291 Da
Caution: Positions 27 to 191 are in EST BF328700; positions 244 to 492 can be found in EST BG291497 but several
frameshifts need to be corrected to restore the correct sequence. Positions 412 to 492 are in AF086251 with no
conflicts
Secondary accessions: Q96AD1
Alternative splicing: 3 isoforms:  P58005-1   P58005-2   P58005-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SESN3: NX_P58005

Explore proteomics data for SESN3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys378
  • Modification sites at PhosphoSitePlus

  • See SESN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258523.1  NP_653266.2  

    ENSEMBL proteins: 
     ENSP00000441927   ENSP00000278499   ENSP00000407008   ENSP00000439580   ENSP00000376926  

    SESN3 Human Recombinant Protein Products:

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    Novus Biologicals SESN3 Proteins
    Novus Biologicals SESN3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SESN3

     
    Search eBioscience for Proteins for SESN3 

    SESN3 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SESN3

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    Cloud-Clone Corp. ELISAs for SESN3
    Cloud-Clone Corp. CLIAs for SESN3
    Search eBioscience for ELISAs for SESN3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006730 PA26

    Graphical View of Domain Structure for InterPro Entry P58005

    ProtoNet protein and cluster: P58005

    1 Blocks protein domain: IPB006730 PA26 p53-induced protein (sestrin)

    UniProtKB/Swiss-Prot: SESN3_HUMAN, P58005
    Similarity: Belongs to the sestrin family


    Find genes that share domains with SESN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sesn3):
     behavior/neurological  growth/size/body  homeostasis/metabolism  liver/biliary system 

    Find genes that share phenotypes with SESN3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SESN3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SESN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SESN3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SESN3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SESN3:
    hsa-mir-335-5p (MIRT017124), hsa-mir-590-3p (MIRT016230)

    Block miRNA regulation of human, mouse, rat SESN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SESN3 (see all 10):
    hsa-miR-4317 hsa-miR-92a hsa-miR-4268 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-514 hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmidSESN3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SESN3
    Predesigned siRNA for gene silencing in human, mouse, rat SESN3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SESN3

    Clone
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    OriGene clones in human, mouse for SESN3 (see all 6)
    OriGene ORF clones in mouse, rat for SESN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SESN3 (NM_144665)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESN3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SESN3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with SESN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SESN3 About    
    See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    p53 signaling pathway0.41


    Find genes that share SuperPaths with SESN3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SESN3):
        p53 signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SESN3
    Interactions:

        Search GeneGlobe Interaction Network for SESN3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for SESN3 (P580053 ENSP000002784994) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206379O759553I2D: score=3 
    ENSG00000206480O759553I2D: score=3 
    ENSG00000230143O759553I2D: score=3 
    ENSG00000232280O759553I2D: score=3 
    FLOT1O759553I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007050cell cycle arrest IEA--

    Find genes that share ontologies with SESN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SESN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SESN3 gene (2 alternative transcripts): 
    NM_001271594.1  NM_144665.3  

    Unigene Cluster for SESN3:

    Sestrin 3
    Hs.120633  [show with all ESTs]
    Unigene Representative Sequence: NM_144665
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536441(uc001pfk.1) ENST00000278499(uc010rug.1) ENST00000416495(uc001pfl.3)
    ENST00000542176 ENST00000537480 ENST00000393234
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SESN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SESN3 (see all 10):
    hsa-miR-4317 hsa-miR-92a hsa-miR-4268 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-514 hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmidSESN3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SESN3
    Predesigned siRNA for gene silencing in human, mouse, rat SESN3
    Clone
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    OriGene clones in human, mouse for SESN3 (see all 6)
    OriGene ORF clones in mouse, rat for SESN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SESN3 (NM_144665)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SESN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESN3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SESN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SESN3
      QuantiTect SYBR Green Assays in human, mouse, rat SESN3
      QuantiFast Probe-based Assays in human, mouse, rat SESN3

    Additional mRNA sequence: 

    AB072894.1 AF086251.1 AF086504.1 AK091132.1 AK096300.1 AK302366.1 AL832673.1 BC013939.1 
    BC017296.2 BC045700.1 BX649128.1 

    15 DOTS entries:

    DT.119784  DT.101974330  DT.95253550  DT.309177  DT.91917292  DT.120700737  DT.120700770  DT.100814636 
    DT.120700798  DT.100814639  DT.91850014  DT.91872509  DT.95126139  DT.120700800  DT.99980189 

    Selected AceView cDNA sequences (see all 305):

    AI377592 AU185628 Z39807 W95555 BM474307 AW089590 AI922209 N22249 
    AA827189 AW173255 AK096300 AA648303 BQ882905 N64382 AA461226 AA928759 
    BC017296 BU580688 R95457 AA333874 BP369602 BU161785 CA843411 BX951920 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SESN3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                    -     -                                                                           
    SP2:              -     -                                                                                 
    SP3:              -     -     -                                                                           
    SP4:                          -                                                                           


    ECgene alternative splicing isoforms for SESN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SESN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCTGGCGT
    SESN3 Expression
    About this image


    SESN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    SESN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SESN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.120633

    UniProtKB/Swiss-Prot: SESN3_HUMAN, P58005
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SESN3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sesn31 , 5 sestrin 31, 5 88.48(n)1
    93.9(a)1
      9 (3.89 cM)5
    757471  NM_030261.41  NP_084537.21 
     142763015 
    chicken
    (Gallus gallus)
    Aves SESN31 sestrin 3 84.43(n)
    92.76(a)
      428089  XM_004938846.1  XP_004938903.1 
    lizard
    (Anolis carolinensis)
    Reptilia SESN36
    sestrin 3
    87(a)
    1 ↔ 1
    3(195525628-195540762)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.123442 Xenopus laevis transcribed sequence with moderate similarity more 82.83(n)    BJ074225.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.51292 Danio rerio cDNA clone MGC56722 IMAGE2601412, complete more 73.07(n)    BC045518.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sesn1 Sestrin 54.79(n)
    51.84(a)
      37755  NM_001103968.1  NP_001097438.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sesn-11 sesn-1 45.84(n)
    31.51(a)
      171593  NM_058263.4  NP_490664.2 


    ENSEMBL Gene Tree for SESN3 (if available)
    TreeFam Gene Tree for SESN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SESN3 gene
    SESN12  SESN22  
    2 SIMAP similar genes for SESN3 using alignment to 3 protein entries:     SESN3_HUMAN (see all proteins):
    SESN1    SESN2

    Find genes that share paralogs with SESN3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SESN3 (see all 1040)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710363791,2
    C--91005893(-) CTGCT-/ATTAA 
            
    ATTAT
    2 -- int11Minor allele frequency- ATTAA:0.00NA 2
    rs1900207851,2
    --94898177(+) CATTCA/CAGCTC 2 -- ds50010--------
    rs1489005071,2
    --94898213(+) CATGAA/GTACAC 2 -- ds50010--------
    rs1811536801,2
    --94898223(+) CATCAC/GCTAAT 2 -- ds50010--------
    rs1175910531,2
    F--94898240(+) CCATCT/GCAAGA 2 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1851950011,2
    --94898313(+) AAGGTC/TGCAAA 2 -- ds50010--------
    rs1469957671,2
    --94898548(+) GTGAGA/TGATAA 2 -- ds50010--------
    rs1381159291,2
    --94898572(+) GAAACG/TGGGTC 2 -- ds50010--------
    rs1128858221,2
    F--94898994(+) CTAGAC/ATATTA 2 -- ut311Minor allele frequency- A:0.50CSA 2
    rs618936951,2
    C,F--94899042(+) ACTGTA/GAAATC 2 -- ut312Minor allele frequency- G:0.04NA 122

    HapMap Linkage Disequilibrium report for SESN3 (94898704 - 94965705 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SESN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv989063CNV Deletion20482838
    esv2677596CNV Deletion23128226
    nsv447CNV Loss18451855
    esv994857CNV Loss20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SESN3
    DNA2.0 Custom Variant and Variant Library Synthesis for SESN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607768    OMIM disorders: --

    2 diseases for SESN3:    
    About MalaCards
    insulin resistance    obesity


    Find genes that share disorders with SESN3           About GenesLikeMe

    Genetic Association Database (GAD): SESN3
    Human Genome Epidemiology (HuGE) Navigator: SESN3 (1 document)

    Export disorders for SESN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SESN3 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SESN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. (PubMed id 12607115)1, 2, 3 Peeters H.... Devriendt K. (Hum. Genet. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability. (PubMed id 17510393)1, 9 Kopnin P.B....Chumakov P.M. (Cancer Res. 2007)
    6. Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways. (PubMed id 23388456)1 Zamkova M....Kopnin P. (Cell Cycle 2013)
    7. Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle. (PubMed id 24129397)1 Nascimento E.B....Zierath J.R. (Am. J. Physiol. Endocrinol. Metab. 2013)
    8. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. (PubMed id 22958918)1 Lee J.H....Karin M. (Cell Metab. 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3. (PubMed id 22349704)1 Hagenbuchner J....Ausserlechner M.J. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 143686 HGNC: 23060 AceView: SESN3 Ensembl:ENSG00000149212 euGenes: HUgn143686
    ECgene: SESN3 Kegg: 143686 H-InvDB: SESN3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SESN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SESN3 gene:
    Search GeneIP for patents involving SESN3

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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