Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SESN3 Gene

protein-coding GIFtS: 52
GCID: GC11M094906

sestrin 3

Search for SESN3
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sestrin 3¹ ²
SEST3¹ ² ³ ⁵
MGC29667¹
Sestrin-3¹

External Ids:	HGNC: 23060¹	Entrez Gene: 143686²	Ensembl: ENSG00000149212⁷	OMIM: 607768⁵	UniProtKB: P58005³

Export aliases for SESN3 gene to outside databases

Previous GC identifers: GC11M095090 GC11M094594 GC11M094545 GC11M090971

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SESN3:

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of

intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase

(Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin

resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.

(provided by RefSeq, Oct 2012)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SESN3 gene promoter:
USF1 SREBP-1c NF-YA NF-YB CBF-A CBF-B USF-1 CP1A NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SESN3 promoter sequence

Search SABiosciences Chromatin IP Primers for SESN3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SESN3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21 Ensembl cytogenetic band: 11q21 HGNC cytogenetic band: 11q21

SESN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SESN3 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M094906: view genomic region (about GC identifiers)

Start:	94,898,704 bp from pter	End:	94,965,705 bp from pter
Size:	67,002 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SESN3_HUMAN, P58005 (See protein sequence)

Recommended Name: Sestrin-3

Size: 492 amino acids; 57291 Da

Caution: Positions 27 to 191 are in EST BF328700; positions 244 to 492 can be found in EST BG291497 but several

frameshifts need to be corrected to restore the correct sequence. Positions 412 to 492 are in AF086251 with no

conflicts

Secondary accessions: Q96AD1

Alternative splicing: 3 isoforms: P58005-1 P58005-2 P58005-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SESN3: NX_P58005

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P58005

SESN3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001258523.1 NP_653266.2

ENSEMBL proteins:

ENSP00000441927 ENSP00000278499 ENSP00000407008 ENSP00000439580 ENSP00000376926

Human Recombinant Protein Products for SESN3:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SESN3 OriGene Custom Protein Services for SESN3
	GenScript Custom Purified and Recombinant Proteins Services for SESN3
	Novus Biologicals SESN3 Proteins Novus Biologicals SESN3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SESN3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

SESN3 for ontologies About GeneDecksing

SESN3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: SESN3 OriGene Custom Antibody Services for SESN3
	GenScript Custom Superior Antibodies Services for SESN3
	Novus Biologicals SESN3 Antibodies
	Abcam antibodies for SESN3
	Uscn Antibodies for SESN3
	ThermoFisher Antibodies for SESN3

Assay Products for SESN3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SESN3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SESN3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SESN3 for domains About GeneDecksing

1 InterPro domain/family:

IPR006730 PA26

Graphical View of Domain Structure for InterPro Entry P58005

ProtoNet protein and cluster: P58005

1 Blocks protein family: IPB006730 PA26 p53-induced protein (sestrin)

UniProtKB/Swiss-Prot: SESN3_HUMAN, P58005

Similarity: Belongs to the sestrin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sesn3):

behavior/neurological

growth/size

homeostasis/metabolism

liver/biliary system

SESN3 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SESN3

miRNA Products:		OriGene 3'-UTR Clone: SESN3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SESN3
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SESN3 (see all 10):
		hsa-miR-4317 hsa-miR-92a hsa-miR-4268 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-514 hsa-miR-363

		SwitchGear 3'UTR luciferase reporter plasmid: SESN3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SESN3 (see all 7) OriGene shRNA RFP: SESN3 OriGene siRNA: SESN3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SESN3
		Sirion Biotech Custom design and validation of potent shRNA sequences against SESN3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SESN3
			Sirion Biotech Customized adenovirus for overexpression of SESN3 Sirion Biotech Customized adenovirus for potent knockdown of SESN3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SESN3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SESN3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SESN3 (NM_144665)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SESN3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESN3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SESN3
		Search LifeMap BioReagents cell lines for SESN3
		Sirion Biotech Customized stable knockdown cell line services for SESN3 Sirion Biotech Customized inducible knockdown cell line services for SESN3 Sirion Biotech Customized stable overexpressing cell line services for SESN3 Sirion Biotech Customized inducible overexpressing cell line services for SESN3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESN3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

p53 signaling pathway

p53 signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for SESN3):

p53 signaling pathway

SESN3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SESN3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for SESN3 (P58005³ ENSP00000278499⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FLOT1	O75955³	I2D: score=3
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007050	cell cycle arrest	IEA	--

SESN3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SESN3
Search CenterWatch for drugs/clinical trials and news about SESN3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SESN3 gene (2 alternative transcripts):

NM_001271594.1 NM_144665.3

Unigene Cluster for SESN3:

Sestrin 3

Hs.120633 [show with all ESTs]

Unigene Representative Sequence: NM_144665

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000536441(uc001pfk.1) ENST00000278499(uc010rug.1) ENST00000416495(uc001pfl.3)

ENST00000542176 ENST00000537480 ENST00000393234

miRNA Products:		OriGene 3'-UTR Clone: SESN3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SESN3
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SESN3 (see all 10):
		hsa-miR-4317 hsa-miR-92a hsa-miR-4268 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-514 hsa-miR-363

		SwitchGear 3'UTR luciferase reporter plasmid: SESN3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SESN3 (see all 7) OriGene shRNA RFP: SESN3 OriGene siRNA: SESN3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SESN3
		Sirion Biotech Custom design and validation of potent shRNA sequences against SESN3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SESN3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SESN3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SESN3 (NM_144665)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SESN3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESN3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SESN3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SESN3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SESN3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SESN3

Additional cDNA sequence:

AB072894.1 AF086251.1 AF086504.1 AK091132.1 AK096300.1 AK302366.1 AL832673.1 BC013939.1

BC017296.2 BC045700.1 BX649128.1

15 DOTS entries:

DT.119784 DT.101974330 DT.95253550 DT.309177 DT.91917292 DT.120700737 DT.120700770 DT.100814636

DT.120700798 DT.100814639 DT.91850014 DT.91872509 DT.95126139 DT.120700800 DT.99980189

24/305 AceView cDNA sequences (see all 305):

Z42328 BM454331 BC017296 AV652246 CK903926 AU185628 BG261007 BM052709

W95555 AI373842 BX951920 CA445199 N22249 BU161785 BM052986 BG697235

AI460355 AA905500 NM_144665 AA827189 BM984875 BP369602 AA928759 BQ002853

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SESN3 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13
SP1:							-		-
SP2:					-		-
SP3:					-		-		-
SP4:									-

ECgene alternative splicing isoforms for SESN3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SESN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCTGGCGT

About this image

SESN3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

Trophoblast-like cells (Generation of tropho...)

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SESN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SESN3

SOURCE GeneReport for Unigene cluster: Hs.120633

UniProtKB/Swiss-Prot: SESN3_HUMAN, P58005

Tissue specificity: Widely expressed

SABiosciences Custom PCR Arrays for SESN3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SESN3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SESN3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SESN3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SESN3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESN3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SESN3 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SESN3¹	sestrin 3	84.38(n) 92.19(a)		428089 XM_425647.3 XP_425647.3
lizard (Anolis carolinensis)	Reptilia	SESN3⁶	--	87(a)	1 ↔ 1	3(195525628-195540762)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12344²	Xenopus laevis transcribed sequence with moderate similarity more	82.83(n)		BJ074225.1
zebrafish (Danio rerio)	Actinopterygii	Dr.5129²	Danio rerio cDNA clone MGC56722 IMAGE2601412, complete more	73.07(n)		BC045518.1
fruit fly (Drosophila melanogaster)	Insecta	Sesn¹	Sestrin	54.69(n) 51.1(a)		37755 NM_137977.3 NP_611821.1
worm (Caenorhabditis elegans)	Secernentea	sesn-1¹	Protein SESN-1	45.68(n) 31.35(a)		171593 NM_058263.3 NP_490664.2

ENSEMBL Gene Tree for SESN3 (if available)
TreeFam Gene Tree for SESN3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SESN3 gene

SESN1² SESN2²

2 SIMAP similar genes for SESN3 using alignment to 3 protein entries: SESN3_HUMAN (see all proteins):

SESN1 SESN2

SESN3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74343992^1,2	F	--	91028217(+)	`CAACAC/GGGGGG`	1	--	us2k¹		1		WA	118
rs10831321^1,2	C,F,A,H	--	91029302(+)	`CCACCG/ACCGCC`	1	--	us2k¹		4		NA CSA	7
rs77749449^1,2	F	--	91029531(+)	`AGGCTC/AGGAAC`	1	--	us2k¹		1		EA	120
rs11827047^1,2	C,F,A,H	--	91029620(+)	`TGTGTC/TATATG`	1	--	nc-transcript-varianttfbs³		2		NA WA	122
rs73530853^1,2	C	--	91029837(+)	`TAGGCC/TTTCTC`	1	--	int¹		1		WA	2
rs73530857^1,2	C	--	91030319(+)	`TAGCGT/CCCACG`	1	--	int¹		2		WA	120
rs12278685^1,2	C	--	91030618(+)	`CACCCG/AGCCAT`	1	--	int¹		1		WA	2
rs190020785^1,2		--	94898177(+)	`CATTCA/CAGCTC`	2	--	ds500¹		0	--	--	--	--
rs148900507^1,2		--	94898213(+)	`CATGAA/GTACAC`	2	--	ds500¹		0	--	--	--	--
rs181153680^1,2		--	94898223(+)	`CATCAC/GCTAAT`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SESN3 (94898704 - 94965705 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SESN3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SESN3

DNA2.0 Custom Variant and Variant Library Synthesis for SESN3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SESN3 for disorders About MalaCards

SESN3 for disorders About GeneDecksing

OMIM gene information: 607768 OMIM disorders: --

Human Genome Epidemiology (HuGE) Navigator: SESN3 (1 document)

Export disorders for SESN3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SESN3 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with SESN3)

Utopia: connect your pdf to the dynamic
world of online information

PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. (PubMed id 12607115)^{1, 2, 3} Peeters H.... Devriendt K. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability. (PubMed id 17510393)^{1, 9} Kopnin P.B....Chumakov P.M. (2007)
Maintenance of metabolic homeostasis by Sestrin2 and S estrin3. (PubMed id 22958918)¹ Lee J.H....Karin M. (2012)
FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3. (PubMed id 22349704)¹ Hagenbuchner J....Ausserlechner M.J. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. (PubMed id 20412774)¹ Chen C.C....Hay N. (2010)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 143686	HGNC: 23060	AceView: SESN3	Ensembl:ENSG00000149212	euGenes: HUgn143686
ECgene: SESN3	Kegg: 143686	H-InvDB: SESN3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SESN3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SESN3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SESN3 gene:
Search GeneIP for patents involving SESN3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for SESN3		OriGene shRNA RFP for SESN3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SESN3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SESN3
	OriGene Protein Over-expression Lysate for SESN3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SESN3		OriGene 3'-UTR Clone for SESN3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SESN3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SESN3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SESN3		OriGene Custom Protein Services for SESN3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SESN3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SESN3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SESN3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SESN3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SESN3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SESN3

	GenScript Custom Purified and Recombinant Proteins Services for SESN3		GenScript cDNA clones with any tag delivered in your preferred vector for SESN3
	GenScript Custom Assay Services for SESN3		GenScript Custom Superior Antibodies Services for SESN3
	GenScript Custom overexpressing Cell Line Services for SESN3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SESN3 promoter
	Search Chromatin IP Primers for SESN3
	RT² qPCR Primer Assay in human, mouse, rat SESN3
	Search GNC Networks for SESN3
	SABiosciences Custom PCR Arrays for SESN3

Search Tocris compounds for SESN3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SESN3 antibodies
	SESN3 proteins
	SESN3 lysates

	Antibodies for SESN3
	See all of Abcam's Antibodies, Kits and Proteins for SESN3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SESN3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SESN3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESN3

	SwitchGear 3'UTR luciferase reporter plasmids for SESN3
	SwitchGear Promoter luciferase reporter plasmids for SESN3

ThermoFisher Antibodies for SESN3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESN3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SESN3

Sirion Biotech Customized:

	stable knockdown cell line services for SESN3
	inducible knockdown cell line services for SESN3
	design and validation of potent shRNA sequences against SESN3
	adenovirus for potent knockdown of SESN3
	adenovirus for overexpression of SESN3
	stable overexpressing cell line services for SESN3
	inducible overexpressing cell line services for SESN3

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SESN3 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

SESN3 Gene

sestrin 3

Aliases
for SESN3 gene

Summaries
for SESN3 gene

Genomic Views
for SESN3 gene

Proteins
for SESN3 gene

Protein Domains /
Families
for SESN3 gene

Function
for SESN3 gene

Pathways & Interactions
for SESN3 gene

Drugs & Compounds
for SESN3 gene

Transcripts
for SESN3 gene

Expression
for SESN3 gene

Orthologs
for SESN3 gene

Paralogs
for SESN3 gene

Genomic Variants
for SESN3 gene

Disorders / Diseases
for SESN3 gene

Publications
for SESN3 gene

External Searches for SESN3 gene

Genome Databases showing SESN3 gene

Other Databases showing SESN3 gene

Specialized Databases showing SESN3 gene

Intellectual Property
for SESN3 gene

Products
for SESN3 gene

View Random Gene

Advanced Search

Export list of displayed genes

SESN3 Gene

sestrin 3

Aliasesfor SESN3 gene

Summariesfor SESN3 gene

Genomic Viewsfor SESN3 gene

Proteinsfor SESN3 gene

Protein Domains /Familiesfor SESN3 gene

Functionfor SESN3 gene

Pathways & Interactionsfor SESN3 gene

Drugs & Compoundsfor SESN3 gene

Transcriptsfor SESN3 gene

Expression for SESN3 gene

Orthologsfor SESN3 gene

Paralogsfor SESN3 gene

Genomic Variantsfor SESN3 gene

Disorders / Diseasesfor SESN3 gene

Publicationsfor SESN3 gene

External Searches for SESN3 gene

Genome Databases showing SESN3 gene

Other Databases showing SESN3 gene

Specialized Databases showing SESN3 gene

Intellectual Propertyfor SESN3 gene

Productsfor SESN3 gene

View Random Gene

Aliases
for SESN3 gene

Summaries
for SESN3 gene

Genomic Views
for SESN3 gene

Proteins
for SESN3 gene

Protein Domains /
Families
for SESN3 gene

Function
for SESN3 gene

Pathways & Interactions
for SESN3 gene

Drugs & Compounds
for SESN3 gene

Transcripts
for SESN3 gene

Expression
for SESN3 gene

Orthologs
for SESN3 gene

Paralogs
for SESN3 gene

Genomic Variants
for SESN3 gene

Disorders / Diseases
for SESN3 gene

Publications
for SESN3 gene

Intellectual Property
for SESN3 gene

Products
for SESN3 gene