Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SESN2 Gene

Aliases for SESN2 Gene

  • Sestrin 2 2 3 5
  • SEST2 3 4
  • HI95 3 4
  • Hypoxia Induced Gene 95 3
  • Ses2 3

External Ids for SESN2 Gene

Previous GeneCards Identifiers for SESN2 Gene

  • GC01P027819
  • GC01P028190
  • GC01P028458
  • GC01P028586
  • GC01P026842

Summaries for SESN2 Gene

Entrez Gene Summary for SESN2 Gene

  • This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]

GeneCards Summary for SESN2 Gene

SESN2 (Sestrin 2) is a Protein Coding gene. Diseases associated with SESN2 include Pulmonary Emphysema. Among its related pathways are p53 Pathway (RnD) and Gene Expression. An important paralog of this gene is SESN3.

UniProtKB/Swiss-Prot for SESN2 Gene

  • Involved in the reduction of peroxiredoxins.

Gene Wiki entry for SESN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SESN2 Gene

Genomics for SESN2 Gene

Regulatory Elements for SESN2 Gene

Enhancers for SESN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SESN2 on UCSC Golden Path with GeneCards custom track

Promoters for SESN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SESN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SESN2 Gene

Chromosome:
1
Start:
28,259,452 bp from pter
End:
28,282,491 bp from pter
Size:
23,040 bases
Orientation:
Plus strand

Genomic View for SESN2 Gene

Genes around SESN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SESN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SESN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SESN2 Gene

Proteins for SESN2 Gene

  • Protein details for SESN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58004-SESN2_HUMAN
    Recommended name:
    Sestrin-2
    Protein Accession:
    P58004
    Secondary Accessions:
    • Q5T7D0
    • Q96SI5

    Protein attributes for SESN2 Gene

    Size:
    480 amino acids
    Molecular mass:
    54494 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55438.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SESN2 Gene

neXtProt entry for SESN2 Gene

Proteomics data for SESN2 Gene at MOPED

Post-translational modifications for SESN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SESN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SESN2 (SESN2)
  • Abcam antibodies for SESN2

No data available for DME Specific Peptides for SESN2 Gene

Domains & Families for SESN2 Gene

Protein Domains for SESN2 Gene

Suggested Antigen Peptide Sequences for SESN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P58004

UniProtKB/Swiss-Prot:

SESN2_HUMAN :
  • Belongs to the sestrin family.
Family:
  • Belongs to the sestrin family.
genes like me logo Genes that share domains with SESN2: view

No data available for Gene Families for SESN2 Gene

Function for SESN2 Gene

Molecular function for SESN2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the reduction of peroxiredoxins.
genes like me logo Genes that share phenotypes with SESN2: view

Animal Model Products

miRNA for SESN2 Gene

miRTarBase miRNAs that target SESN2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SESN2 Gene

Localization for SESN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SESN2 Gene COMPARTMENTS Subcellular localization image for SESN2 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 3
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SESN2 Gene

Pathways & Interactions for SESN2 Gene

genes like me logo Genes that share pathways with SESN2: view

Pathways by source for SESN2 Gene

1 Cell Signaling Technology pathway for SESN2 Gene
2 KEGG pathways for SESN2 Gene
1 R&D Systems pathway for SESN2 Gene

Gene Ontology (GO) - Biological Process for SESN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007005 mitochondrion organization IEA --
GO:0009749 response to glucose IEA --
GO:0010467 gene expression TAS --
GO:0032042 mitochondrial DNA metabolic process IEA --
GO:0042593 glucose homeostasis IEA --
genes like me logo Genes that share ontologies with SESN2: view

No data available for SIGNOR curated interactions for SESN2 Gene

Drugs & Compounds for SESN2 Gene

No Compound Related Data Available

Transcripts for SESN2 Gene

mRNA/cDNA for SESN2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(225) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SESN2 Gene

Sestrin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SESN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2: -

Relevant External Links for SESN2 Gene

GeneLoc Exon Structure for
SESN2
ECgene alternative splicing isoforms for
SESN2

Expression for SESN2 Gene

mRNA expression in normal human tissues for SESN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SESN2 Gene

This gene is overexpressed in Liver (20.9), Testis (15.0), Islet of Langerhans (11.5), and Pancreas (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SESN2 Gene



SOURCE GeneReport for Unigene cluster for SESN2 Gene Hs.469543

mRNA Expression by UniProt/SwissProt for SESN2 Gene

P58004-SESN2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SESN2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SESN2 Gene

Orthologs for SESN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SESN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SESN2 35
  • 90.51 (n)
  • 93.72 (a)
SESN2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SESN2 35
  • 90.42 (n)
  • 94.79 (a)
SESN2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sesn2 35
  • 88.06 (n)
  • 91.46 (a)
Sesn2 16
Sesn2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SESN2 35
  • 99.36 (n)
  • 100 (a)
SESN2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sesn2 35
  • 87.85 (n)
  • 91.87 (a)
oppossum
(Monodelphis domestica)
Mammalia SESN2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SESN2 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves SESN2 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SESN2 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sesn2 35
  • 63.16 (n)
  • 65.28 (a)
zebrafish
(Danio rerio)
Actinopterygii sesn2 35
  • 63.55 (n)
  • 63.55 (a)
sesn2 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sesn 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sesn-1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3472 36
  • 30 (a)
OneToMany
Species with no ortholog for SESN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SESN2 Gene

ENSEMBL:
Gene Tree for SESN2 (if available)
TreeFam:
Gene Tree for SESN2 (if available)

Paralogs for SESN2 Gene

Paralogs for SESN2 Gene

(2) SIMAP similar genes for SESN2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SESN2: view

Variants for SESN2 Gene

Sequence variations from dbSNP and Humsavar for SESN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2274848 - 28,274,096(-) GAAAG(C/T)AGGGT nc-transcript-variant, reference, missense
rs13886 -- 28,282,287(-) AGGCC(G/T)GAAGG nc-transcript-variant, utr-variant-3-prime
rs476243 -- 28,264,331(-) ttttt(C/T)ctttt intron-variant
rs487437 -- 28,271,509(-) TCAAT(A/G)AATAC intron-variant
rs379590 -- 28,266,934(-) GAGCT(C/T)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SESN2 Gene

Variant ID Type Subtype PubMed ID
nsv871151 CNV Gain 21882294
dgv208n71 CNV Gain 21882294
esv994212 CNV Deletion 20482838

Variation tolerance for SESN2 Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SESN2 Gene

Human Gene Mutation Database (HGMD)
SESN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SESN2 Gene

Disorders for SESN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SESN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pulmonary emphysema
- elite association - COSMIC cancer census association via MalaCards
Search SESN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SESN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SESN2
genes like me logo Genes that share disorders with SESN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SESN2 Gene

Publications for SESN2 Gene

  1. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. (PMID: 12607115) Peeters H. … Devriendt K. (Hum. Genet. 2003) 2 3 4 67
  2. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. (PMID: 15105503) Budanov A.V. … Chumakov P.M. (Science 2004) 3 23
  3. Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. (PMID: 12203114) Budanov A.V. … Feinstein E. (Oncogene 2002) 2 3
  4. Sestrin2 is a leucine sensor for the mTORC1 pathway. (PMID: 26449471) Wolfson R.L. … Sabatini D.M. (Science 2016) 3
  5. Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. (PMID: 26586190) Saxton R.A. … Sabatini D.M. (Science 2016) 3

Products for SESN2 Gene

Sources for SESN2 Gene

Content