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Aliases for SESN2 Gene

Aliases for SESN2 Gene

  • Sestrin 2 2 3
  • SEST2 3 4 6
  • HI95 3 4 6
  • Hypoxia Induced Gene 95 3
  • Sestrin-2 3
  • Ses2 3

External Ids for SESN2 Gene

Previous GeneCards Identifiers for SESN2 Gene

  • GC01P027819
  • GC01P028190
  • GC01P028458
  • GC01P028586
  • GC01P026842

Summaries for SESN2 Gene

Entrez Gene Summary for SESN2 Gene

  • This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]

GeneCards Summary for SESN2 Gene

SESN2 (Sestrin 2) is a Protein Coding gene. Among its related pathways are Cell Cycle / Checkpoint Control and Cell Cycle / Checkpoint Control. An important paralog of this gene is SESN3.

UniProtKB/Swiss-Prot for SESN2 Gene

  • Involved in the reduction of peroxiredoxins.

Gene Wiki entry for SESN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SESN2 Gene

Genomics for SESN2 Gene

Regulatory Elements for SESN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SESN2 Gene

28,259,452 bp from pter
28,282,491 bp from pter
23,040 bases
Plus strand

Genomic View for SESN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SESN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SESN2 Gene

Proteins for SESN2 Gene

  • Protein details for SESN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5T7D0
    • Q96SI5

    Protein attributes for SESN2 Gene

    480 amino acids
    Molecular mass:
    54494 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB55438.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SESN2 Gene

Proteomics data for SESN2 Gene at MOPED

Post-translational modifications for SESN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SESN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SESN2 (SESN2)

No data available for DME Specific Peptides for SESN2 Gene

Domains for SESN2 Gene

Protein Domains for SESN2 Gene

Suggested Antigen Peptide Sequences for SESN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P58004
  • Belongs to the sestrin family.
genes like me logo Genes that share domains with SESN2: view

No data available for Gene Families for SESN2 Gene

Function for SESN2 Gene

Molecular function for SESN2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the reduction of peroxiredoxins.

Gene Ontology (GO) - Molecular Function for SESN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25040165
genes like me logo Genes that share ontologies with SESN2: view
genes like me logo Genes that share phenotypes with SESN2: view

Animal Model Products

miRNA for SESN2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SESN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SESN2 Gene

Localization for SESN2 Gene

Subcellular locations from

Jensen Localization Image for SESN2 Gene COMPARTMENTS Subcellular localization image for SESN2 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SESN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SESN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SESN2 Gene

Pathways for SESN2 Gene

genes like me logo Genes that share pathways with SESN2: view

Pathways by source for SESN2 Gene

2 Cell Signaling Technology pathways for SESN2 Gene
1 KEGG pathway for SESN2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SESN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006635 fatty acid beta-oxidation IEA --
GO:0006914 autophagy IEA --
GO:0007005 mitochondrion organization --
genes like me logo Genes that share ontologies with SESN2: view

Transcripts for SESN2 Gene

mRNA/cDNA for SESN2 Gene

(225) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SESN2 Gene

Sestrin 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SESN2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SESN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP2: -

Relevant External Links for SESN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SESN2 Gene

mRNA expression in normal human tissues for SESN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SESN2 Gene

This gene is overexpressed in Liver (20.9), Testis (15.0), Islet of Langerhans (11.5), and Pancreas (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SESN2 Gene

SOURCE GeneReport for Unigene cluster for SESN2 Gene Hs.469543

mRNA Expression by UniProt/SwissProt for SESN2 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with SESN2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for SESN2 Gene

Orthologs for SESN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SESN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SESN2 35
  • 90.51 (n)
  • 93.72 (a)
SESN2 36
  • 85 (a)
(Canis familiaris)
Mammalia SESN2 35
  • 90.42 (n)
  • 94.79 (a)
SESN2 36
  • 94 (a)
(Mus musculus)
Mammalia Sesn2 35
  • 88.06 (n)
  • 91.46 (a)
Sesn2 16
Sesn2 36
  • 91 (a)
(Pan troglodytes)
Mammalia SESN2 35
  • 99.36 (n)
  • 100 (a)
SESN2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sesn2 35
  • 87.85 (n)
  • 91.87 (a)
(Monodelphis domestica)
Mammalia SESN2 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SESN2 36
  • 59 (a)
(Gallus gallus)
Aves SESN2 36
  • 62 (a)
(Anolis carolinensis)
Reptilia SESN2 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sesn2 35
  • 63.16 (n)
  • 65.28 (a)
(Danio rerio)
Actinopterygii sesn2 35
  • 63.55 (n)
  • 63.55 (a)
sesn2 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sesn 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea sesn-1 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3472 36
  • 30 (a)
Species with no ortholog for SESN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SESN2 Gene

Gene Tree for SESN2 (if available)
Gene Tree for SESN2 (if available)

Paralogs for SESN2 Gene

Paralogs for SESN2 Gene

Selected SIMAP similar genes for SESN2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SESN2: view

Variants for SESN2 Gene

Sequence variations from dbSNP and Humsavar for SESN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13886 -- 28,282,287(-) AGGCC(G/T)GAAGG utr-variant-3-prime
rs379590 -- 28,266,934(-) GAGCT(C/T)TAAGT intron-variant
rs405336 -- 28,266,964(-) AAAAT(C/T)TGACC intron-variant
rs476243 -- 28,264,331(-) ttttt(C/T)ctttt intron-variant
rs487437 -- 28,271,509(-) TCAAT(A/G)AATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SESN2 Gene

Variant ID Type Subtype PubMed ID
nsv871151 CNV Gain 21882294
dgv208n71 CNV Gain 21882294
esv994212 CNV Deletion 20482838

Relevant External Links for SESN2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SESN2 Gene

Disorders for SESN2 Gene

No disorders were found for SESN2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SESN2 Gene

Publications for SESN2 Gene

  1. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. (PMID: 12607115) Peeters H. … Devriendt K. (Hum. Genet. 2003) 2 3 4
  2. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. (PMID: 15105503) Budanov A.V. … Chumakov P.M. (Science 2004) 3 4 23
  3. Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. (PMID: 12203114) Budanov A.V. … Feinstein E. (Oncogene 2002) 2 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SESN2 Gene

  • Addgene plasmids for SESN2

Sources for SESN2 Gene

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