Aliases for SESN1 Gene
External Ids for SESN1 Gene
Previous GeneCards Identifiers for SESN1 Gene
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for SESN1 Gene
UniProtKB/Swiss-Prot for SESN1 Gene
Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth.