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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SESN1 Gene

protein-coding   GIFtS: 57
GCID: GC06M109353

Sestrin 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sestrin 11 2     P53 Regulated PA26 Nuclear Protein2
PA262 3 5     sestrin-12
SEST12 3 5     P53-Regulated Protein PA263
P53 Activated Gene 262     

External Ids:    HGNC: 215951   Entrez Gene: 272442   Ensembl: ENSG000000805467   OMIM: 6061035   UniProtKB: Q9Y6P53   

Export aliases for SESN1 gene to outside databases

Previous GC identifers: GC06M109307 GC06M109414 GC06M106874


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SESN1 Gene:
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and
play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53
inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the
mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by
regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to
radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Dec 2010)

GeneCards Summary for SESN1 Gene: 
SESN1 (sestrin 1) is a protein-coding gene. Diseases associated with SESN1 include chronic fatigue syndrome, and prostate cancer, and among its related super-pathways are DNA damage response. An important paralog of this gene is SESN2.

UniProtKB/Swiss-Prot: SESN1_HUMAN, Q9Y6P5
Function: Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth

Gene Wiki entry for SESN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SESN1 gene promoter:
         Sox5   Pax-5   Sp1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   POU2F1a   FOXO4   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): SESN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SESN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SESN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

SESN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SESN1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M109353:  view genomic region     (about GC identifiers)

Start:
109,307,640 bp from pter      End:
109,416,022 bp from pter
Size:
108,383 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SESN1_HUMAN, Q9Y6P5 (See protein sequence)
Recommended Name: Sestrin-1  
Size: 492 amino acids; 56557 Da
Subcellular location: Nucleus
Secondary accessions: Q2M2B7 Q5T316 Q9NV00 Q9UPD5 Q9Y6P6
Alternative splicing: 3 isoforms:  Q9Y6P5-1   Q9Y6P5-2   Q9Y6P5-3   

Explore the universe of human proteins at neXtProt for SESN1: NX_Q9Y6P5

Explore proteomics data for SESN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6P5

  • SESN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SESN1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001186862.1  NP_001186863.1  NP_055269.1  

    ENSEMBL proteins: 
     ENSP00000393762   ENSP00000306734   ENSP00000349061  

    Human Recombinant Protein Products for SESN1: 
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    OriGene Custom Protein Services for SESN1
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    Novus Biologicals SESN1 Proteins
    Novus Biologicals SESN1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SESN1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    SESN1 for ontologies           About GeneDecksing



    SESN1 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for SESN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006730 PA26

    Graphical View of Domain Structure for InterPro Entry Q9Y6P5

    ProtoNet protein and cluster: Q9Y6P5

    1 Blocks protein domain: IPB006730 PA26 p53-induced protein (sestrin)

    UniProtKB/Swiss-Prot: SESN1_HUMAN, Q9Y6P5
    Similarity: Belongs to the sestrin family


    SESN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SESN1_HUMAN, Q9Y6P5
    Function: Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth
    Induction: Isoform T2 and isoform T3 are induced by genotoxic stress (UV, gamma-irradiation and cytotoxic drugs)
    in a p53/TP53-dependent manner. Isoform T1 is not induced by p53/TP53

    Phenotypes:
         1 GenomeRNAi human phenotype for SESN1:

     Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SESN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SESN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SESN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SESN1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SESN1
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SESN1 (see all 17):
    hsa-miR-429 hsa-miR-3660 hsa-miR-15a hsa-miR-888* hsa-miR-424 hsa-miR-133a hsa-miR-200b hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidSESN1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SESN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    p53 signaling pathway0.41
    DNA damage response0.41
    2Direct p53 effectors
    Direct p53 effectors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SESN1
        DNA damage response
    Direct p53 effectors


    1         Kegg Pathway  (Kegg details for SESN1):
        p53 signaling pathway


    SESN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SESN1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SESN1 (Q9Y6P53 ENSP000003067344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRDX1Q068303, ENSP000002627464I2D: score=3 STRING: ENSP00000262746
    TP53ENSP000002693054STRING: ENSP00000269305
    PRDX6ENSP000003420264STRING: ENSP00000342026
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006974response to DNA damage stimulus TAS9926927
    GO:0007050cell cycle arrest IEA--
    GO:0008285negative regulation of cell proliferation TAS9926927

    SESN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SESN1

    Search CenterWatch for drugs/clinical trials and news about SESN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SESN1 gene (3 alternative transcripts): 
    NM_001199933.1  NM_001199934.1  NM_014454.2  

    Unigene Cluster for SESN1:

    Sestrin 1
    Hs.591336  [show with all ESTs]
    Unigene Representative Sequence: NM_014454
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436639(uc003psu.3) ENST00000302071(uc021zdp.1) ENST00000356644(uc003pst.4)
    ENST00000520364 ENST00000368971 ENST00000523632 ENST00000517548
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SESN1
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SESN1 (see all 17):
    hsa-miR-429 hsa-miR-3660 hsa-miR-15a hsa-miR-888* hsa-miR-424 hsa-miR-133a hsa-miR-200b hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidSESN1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene ORF clones in mouse, rat for SESN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SESN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESN1
    Sirion Biotech Customized lentivirus for stable overexpression of SESN1 
                         Customized lentivirus expression plasmids for stable overexpression of SESN1 
    Primer
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    OriGene qPCR primer pairs and template standards for SESN1
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SESN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SESN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SESN1

    Additional mRNA sequence: 

    AF033120.1 AF033121.1 AF033122.1 AJ420599.1 AK001886.1 AK290157.1 AK290551.1 AL133559.1 
    BC112036.1 BC113569.1 

    12 DOTS entries:

    DT.216690  DT.95376021  DT.40311689  DT.95376020  DT.100781046  DT.121323699  DT.216688  DT.40191861 
    DT.92456406  DT.103130  DT.91665570  DT.100641467 

    24/178 AceView cDNA sequences (see all 178):

    AA447661 AI360853 BU187483 AI572037 BM561543 AI364080 AI334018 BP374526 
    CB048608 BQ959573 AW149243 AA628206 CN479418 BP376528 BU790426 BF198062 
    AA236091 BU734412 BX100958 AW872833 AW627374 AI638732 AI654249 AU136283 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SESN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCTGTAGA
    SESN1 Expression
    About this image


    See SESN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SESN1

    SOURCE GeneReport for Unigene cluster: Hs.591336

    UniProtKB/Swiss-Prot: SESN1_HUMAN, Q9Y6P5
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for SESN1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SESN1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sesn11 , 5 sestrin 11, 5 88.87(n)1
    95.1(a)1
      10 (22.77 cM)5
    1407421  NM_001162908.11  NP_001156380.11 
     418105745 
    chicken
    (Gallus gallus)
    Aves SESN11 sestrin 1 77.05(n)
    84.43(a)
      421766  XM_419796.2  XP_419796.2 
    lizard
    (Anolis carolinensis)
    Reptilia SESN16
    sestrin 1
    80(a)
    1 ↔ 1
    1(190904840-190971352)
    African clawed frog
    (Xenopus laevis)
    Amphibia sesn1-A2 sestrin 1,nuclear factor XPA26-T2 78.43(n)    AB048259.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sesn11 sestrin 1 70.75(n)
    80.96(a)
      436933  NM_001002660.1  NP_001002660.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sesn6
    Sestrin
    39(a)
    1 → many
    2R(19601425-19620706)
    worm
    (Caenorhabditis elegans)
    Secernentea sesn-16
    Sestrin homolog
    22(a)
    1 → many
    I(27595-32482)


    ENSEMBL Gene Tree for SESN1 (if available)
    TreeFam Gene Tree for SESN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SESN1 gene
    SESN22  SESN32  
    2 SIMAP similar genes for SESN1 using alignment to 1 protein entry:     SESN1_HUMAN:
    SESN2    SESN3

    SESN1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SESN1
    PGOHUM00000240847


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1847 SNPs in SESN1 are shown (see all 1847)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs21809331,2
    H--109305551(+) GAGGAG/ATAACT 3 -- ds50014Minor allele frequency- A:0.00NS EA 418
    rs58790061,2
    C--109305566(+) GAGTTATC/-ATCAC 3 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1417134471,2
    --109305579(+) AACAGC/GTTCAG 3 -- ds50010--------
    rs1829496951,2
    --109305671(+) GTAATG/TCTTAA 3 -- ds50010--------
    rs1500271671,2
    C--109305858(+) TAGAT-/TAGA  
            
    AGAAA
    3 -- ds50010--------
    rs1435561951,2
    --109305993(+) ATTCAC/TGCTTC 3 -- ut310--------
    rs168221,2
    C,F,O,H--109305994(+) TTCACG/ACTTCC 3 -- ut3122Minor allele frequency- A:0.08MN EA NA NS CSA WA 2806
    rs1872450551,2
    --109306058(+) GTTAGC/TGTTTT 3 -- ut310--------
    rs1417861011,2
    --109306171(+) AGAGAC/TTGAAT 3 -- ut310--------
    rs1165931261,2
    C,F--109306190(+) GACTGC/TGCAGC 3 -- ut311Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for SESN1 (109307640 - 109416022 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SESN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv886532CNV Loss21882294
    nsv830768CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606103    OMIM disorders: --

    3 diseases for SESN1:    About MalaCards
    chronic fatigue syndrome    prostate cancer    prostatitis


    SESN1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SESN1
    Human Genome Epidemiology (HuGE) Navigator: SESN1 (2 documents)

    Export disorders for SESN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SESN1 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with SESN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes. (PubMed id 9926927)1, 2, 3, 9 Velasco-Miguel S.... Kley N. (1999)
    2. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. (PubMed id 12607115)1, 2, 9 Peeters H.... Devriendt K. (2003)
    3. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    4. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. (PubMed id 15105503)1, 2 Budanov A.V.... Chumakov P.M. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes. (PubMed id 7938006)1, 3 Buckbinder L....Kley N. (1994)
    7. Regulation of protein synthesis by ionizing radiation . (PubMed id 19704005)1, 9 Braunstein S....Schneider R.J. (2009)
    8. Identification of 23 new prostate cancer susceptibilit y loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (2013)
    9. Sestrins activate Nrf2 by promoting p62-dependent auto phagic degradation of Keap1 and prevent oxidative liver damage. (PubMed id 23274085)1 Bae S.H....Rhee S.G. (2013)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27244 HGNC: 21595 AceView: SESN1 Ensembl:ENSG00000080546 euGenes: HUgn27244
    ECgene: SESN1 Kegg: 27244 H-InvDB: SESN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SESN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SESN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SESN1 gene:
    Search GeneIP for patents involving SESN1

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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