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Aliases for SESN1 Gene

Aliases for SESN1 Gene

  • Sestrin 1 2 3 5
  • SEST1 3 4
  • PA26 3 4
  • P53 Regulated PA26 Nuclear Protein 3
  • P53-Regulated Protein PA26 4
  • P53 Activated Gene 26 3
  • EC 1.11.1.15 4
  • Sestrin-1 3

External Ids for SESN1 Gene

Previous GeneCards Identifiers for SESN1 Gene

  • GC06M109307
  • GC06M109353
  • GC06M109414
  • GC06M106874

Summaries for SESN1 Gene

Entrez Gene Summary for SESN1 Gene

  • This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for SESN1 Gene

SESN1 (Sestrin 1) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and AMP-activated Protein Kinase (AMPK) Signaling. An important paralog of this gene is SESN3.

UniProtKB/Swiss-Prot for SESN1 Gene

  • Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity).

Gene Wiki entry for SESN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SESN1 Gene

Genomics for SESN1 Gene

Regulatory Elements for SESN1 Gene

Enhancers for SESN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G108555 1.9 FANTOM5 ENCODE dbSUPER 4 +533.2 533158 11.9 CREB3L1 AGO1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 ZBTB24 FOXO3 SMPD2 RNU6-653P ENSG00000271730 LINC00222 SESN1 OSTM1 PIR59886 GC06M108618
GH06G109481 1.5 FANTOM5 ENCODE dbSUPER 2.2 -388.6 -388587 3.1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 YY1 GLIS2 ELK1 ZNF207 SP3 SMPD2 ENSG00000260273 ZBTB24 PPIL6 MICAL1 SESN1 AK9
GH06G108871 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2 +221.1 221114 4.1 FOXA2 TBL1XR1 BMI1 RAD21 EGR1 CBX5 RELB ETV6 IKZF2 CREM ARMC2 RNU6-653P ARMC2-AS1 ZBTB24 SESN1 RPS12P13 ATP5J2P2
GH06G109092 1.4 ENCODE dbSUPER 0.7 +0.2 191 4.9 PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZBTB24 ENSG00000271730 SESN1 GC06M109088
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SESN1 on UCSC Golden Path with GeneCards custom track

Promoters for SESN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000200925 619 4401 PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B

Genomic Location for SESN1 Gene

Chromosome:
6
Start:
108,986,437 bp from pter
End:
109,094,819 bp from pter
Size:
108,383 bases
Orientation:
Minus strand

Genomic View for SESN1 Gene

Genes around SESN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SESN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SESN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SESN1 Gene

Proteins for SESN1 Gene

  • Protein details for SESN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6P5-SESN1_HUMAN
    Recommended name:
    Sestrin-1
    Protein Accession:
    Q9Y6P5
    Secondary Accessions:
    • Q2M2B7
    • Q5T316
    • Q9NV00
    • Q9UPD5
    • Q9Y6P6

    Protein attributes for SESN1 Gene

    Size:
    492 amino acids
    Molecular mass:
    56557 Da
    Quaternary structure:
    • Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by leucine (PubMed:25263562, PubMed:26449471). Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them (PubMed:25259925). Interacts with KEAP1, RBX1 and SQSTM1; in the SQSTM1-dependent autophagic degradation of KEAP1 (PubMed:23274085). May interact with PRDX1 (PubMed:15105503).

    Alternative splice isoforms for SESN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SESN1 Gene

Post-translational modifications for SESN1 Gene

  • Ubiquitination at isoforms=2, 3337
  • Modification sites at PhosphoSitePlus

Other Protein References for SESN1 Gene

No data available for DME Specific Peptides for SESN1 Gene

Domains & Families for SESN1 Gene

Protein Domains for SESN1 Gene

Suggested Antigen Peptide Sequences for SESN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6P5

UniProtKB/Swiss-Prot:

SESN1_HUMAN :
  • Composed of an N-terminal domain that has an alkylhydroperoxide reductase activity and a C-terminal domain that mediates interaction with GATOR2 through which it regulates TORC1 signaling.
  • Belongs to the sestrin family.
Domain:
  • Composed of an N-terminal domain that has an alkylhydroperoxide reductase activity and a C-terminal domain that mediates interaction with GATOR2 through which it regulates TORC1 signaling.
Family:
  • Belongs to the sestrin family.
genes like me logo Genes that share domains with SESN1: view

No data available for Gene Families for SESN1 Gene

Function for SESN1 Gene

Molecular function for SESN1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
UniProtKB/Swiss-Prot Function:
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity).
UniProtKB/Swiss-Prot Induction:
Isoform T2 and isoform T3 are induced by genotoxic stress (UV, gamma-irradiation and cytotoxic drugs) in a p53/TP53-dependent manner. Isoform T1 is not induced by p53/TP53.

Enzyme Numbers (IUBMB) for SESN1 Gene

Gene Ontology (GO) - Molecular Function for SESN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15105503
GO:0016491 oxidoreductase activity IEA --
GO:0051920 peroxiredoxin activity IEA --
GO:0070728 leucine binding IDA 26449471
genes like me logo Genes that share ontologies with SESN1: view
genes like me logo Genes that share phenotypes with SESN1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SESN1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SESN1 Gene

Localization for SESN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SESN1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SESN1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Gene Ontology (GO) - Cellular Components for SESN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA 9926927
GO:0005737 cytoplasm IEA,IDA 15105503
GO:0005829 cytosol TAS --
GO:0061700 colocalizes_with GATOR2 complex IDA 25263562
genes like me logo Genes that share ontologies with SESN1: view

Pathways & Interactions for SESN1 Gene

genes like me logo Genes that share pathways with SESN1: view

Pathways by source for SESN1 Gene

Gene Ontology (GO) - Biological Process for SESN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034198 cellular response to amino acid starvation IMP 25263562
GO:0042149 cellular response to glucose starvation IMP 25263562
GO:0055114 oxidation-reduction process IEA --
GO:0071230 cellular response to amino acid stimulus IMP --
GO:0072593 reactive oxygen species metabolic process IMP 15105503
genes like me logo Genes that share ontologies with SESN1: view

No data available for SIGNOR curated interactions for SESN1 Gene

Drugs & Compounds for SESN1 Gene

No Compound Related Data Available

Transcripts for SESN1 Gene

Unigene Clusters for SESN1 Gene

Sestrin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SESN1

Alternative Splicing Database (ASD) splice patterns (SP) for SESN1 Gene

No ASD Table

Relevant External Links for SESN1 Gene

GeneLoc Exon Structure for
SESN1
ECgene alternative splicing isoforms for
SESN1

Expression for SESN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SESN1 Gene

mRNA differential expression in normal tissues according to GTEx for SESN1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.5).

Protein differential expression in normal tissues from HIPED for SESN1 Gene

This gene is overexpressed in Testis (35.9) and Serum (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SESN1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SESN1 Gene:

SESN1

SOURCE GeneReport for Unigene cluster for SESN1 Gene:

Hs.591336

mRNA Expression by UniProt/SwissProt for SESN1 Gene:

Q9Y6P5-SESN1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SESN1 Gene

  • Lung(4.3)
  • Nervous system(3.9)
  • Muscle(2.6)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with SESN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SESN1 Gene

Orthologs for SESN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SESN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SESN1 34 35
  • 99.76 (n)
cow
(Bos Taurus)
Mammalia SESN1 34 35
  • 95.72 (n)
dog
(Canis familiaris)
Mammalia SESN1 34 35
  • 93.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SESN1 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sesn1 34 16 35
  • 88.87 (n)
rat
(Rattus norvegicus)
Mammalia Sesn1 34
  • 86.67 (n)
oppossum
(Monodelphis domestica)
Mammalia SESN1 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves SESN1 34 35
  • 77.05 (n)
lizard
(Anolis carolinensis)
Reptilia SESN1 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sesn1 34
  • 76.34 (n)
African clawed frog
(Xenopus laevis)
Amphibia sesn1-A 34
zebrafish
(Danio rerio)
Actinopterygii sesn1 34 35
  • 70.82 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10916 34
fruit fly
(Drosophila melanogaster)
Insecta Sesn 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sesn-1 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3472 35
  • 33 (a)
OneToMany
Species where no ortholog for SESN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SESN1 Gene

ENSEMBL:
Gene Tree for SESN1 (if available)
TreeFam:
Gene Tree for SESN1 (if available)

Paralogs for SESN1 Gene

Paralogs for SESN1 Gene

(2) SIMAP similar genes for SESN1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SESN1 Gene

genes like me logo Genes that share paralogs with SESN1: view

Variants for SESN1 Gene

Sequence variations from dbSNP and Humsavar for SESN1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000007652 -- 109,066,651(+) GTAGA(A/G)AAAAG intron-variant
rs1000024959 -- 109,020,925(+) CCTAA(A/C)AAAGG intron-variant
rs1000166344 -- 109,042,762(+) TCACT(-/G)GGATA intron-variant
rs1000166896 -- 109,051,822(+) TTGCT(A/G)TCTCC intron-variant
rs1000167234 -- 109,090,434(+) CCAAC(A/G)ATAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SESN1 Gene

Variant ID Type Subtype PubMed ID
nsv1017230 CNV gain 25217958
nsv1117662 CNV deletion 24896259
nsv830768 CNV gain 17160897
nsv950492 CNV duplication 24416366

Variation tolerance for SESN1 Gene

Residual Variation Intolerance Score: 5.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SESN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SESN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SESN1 Gene

Disorders for SESN1 Gene

Relevant External Links for SESN1

Genetic Association Database (GAD)
SESN1
Human Genome Epidemiology (HuGE) Navigator
SESN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SESN1

No disorders were found for SESN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SESN1 Gene

Publications for SESN1 Gene

  1. PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes. (PMID: 9926927) Velasco-Miguel S. … Kley N. (Oncogene 1999) 2 3 4 22 64
  2. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. (PMID: 12607115) Peeters H. … Devriendt K. (Hum. Genet. 2003) 3 4 22 64
  3. Sestrin2 is a leucine sensor for the mTORC1 pathway. (PMID: 26449471) Wolfson R.L. … Sabatini D.M. (Science 2016) 3 4 64
  4. The Sestrins interact with GATOR2 to negatively regulate the amino- acid-sensing pathway upstream of mTORC1. (PMID: 25263562) Chantranupong L. … Sabatini D.M. (Cell Rep. 2014) 3 4 64
  5. Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. (PMID: 23274085) Bae S.H. … Rhee S.G. (Cell Metab. 2013) 3 4 64

Products for SESN1 Gene

  • Addgene plasmids for SESN1

Sources for SESN1 Gene

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