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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SESN1 Gene

protein-coding GIFtS: 55
GCID: GC06M109353

sestrin 1

Explore 4 diseases affiliated with
SESN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sestrin 1¹ ²		P53 Regulated PA26 Nuclear Protein²
PA26¹ ² ³ ⁵		Sestrin-1¹
SEST1¹ ² ³ ⁵		P53-Regulated Protein PA26³
P53 Activated Gene 26²

External Ids:	HGNC: 21595¹	Entrez Gene: 27244²	Ensembl: ENSG00000080546⁷	OMIM: 606103⁵	UniProtKB: Q9Y6P5³

Export aliases for SESN1 gene to outside databases

Previous GC identifers: GC06M109307 GC06M109414 GC06M106874

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SESN1:

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a

role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell

growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of

rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized

peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced

transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: SESN1_HUMAN, Q9Y6P5

Function: Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth

Gene Wiki entry for SESN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SESN1 gene promoter:
Sox5 Pax-5 Sp1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 POU2F1a FOXO4 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): SESN1 promoter sequence

Search SABiosciences Chromatin IP Primers for SESN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SESN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21

SESN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SESN1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M109353: view genomic region (about GC identifiers)

Start:	109,307,640 bp from pter	End:	109,416,022 bp from pter
Size:	108,383 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SESN1_HUMAN, Q9Y6P5 (See protein sequence)

Recommended Name: Sestrin-1

Size: 492 amino acids; 56557 Da

Subcellular location: Nucleus

Secondary accessions: Q2M2B7 Q5T316 Q9NV00 Q9UPD5 Q9Y6P6

Alternative splicing: 3 isoforms: Q9Y6P5-1 Q9Y6P5-2 Q9Y6P5-3

Explore the universe of human proteins at neXtProt for SESN1: NX_Q9Y6P5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y6P5

SESN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001186862.1 NP_001186863.1 NP_055269.1

ENSEMBL proteins:

ENSP00000393762 ENSP00000306734 ENSP00000349061

Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for SESN1
	Novus Biologicals SESN1 Proteins Novus Biologicals SESN1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SESN1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

SESN1 for ontologies About GeneDecksing

SESN1 Antibody Products:

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	Novus Biologicals SESN1 Antibodies
	Abcam antibodies for SESN1
	Uscn Antibodies for SESN1
	ThermoFisher Antibodies for SESN1

Assay Products for SESN1:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SESN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SESN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SESN1 for domains About GeneDecksing

1 InterPro domain/family:

IPR006730 PA26

Graphical View of Domain Structure for InterPro Entry Q9Y6P5

ProtoNet protein and cluster: Q9Y6P5

1 Blocks protein family: IPB006730 PA26 p53-induced protein (sestrin)

UniProtKB/Swiss-Prot: SESN1_HUMAN, Q9Y6P5

Similarity: Belongs to the sestrin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SESN1_HUMAN, Q9Y6P5

Function: Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth

Induction: Isoform T2 and isoform T3 are induced by genotoxic stress (UV, gamma-irradiation and cytotoxic drugs) in a

p53/TP53-dependent manner. Isoform T1 is not induced by p53/TP53

miRNA Products:		OriGene 3'-UTR Clone: SESN1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SESN1
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SESN1 (see all 17):
		hsa-miR-429 hsa-miR-3660 hsa-miR-15a hsa-miR-888* hsa-miR-424 hsa-miR-133a hsa-miR-200b hsa-miR-24

		SwitchGear 3'UTR luciferase reporter plasmid: SESN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SESN1 (see all 7) OriGene shRNA RFP: SESN1 OriGene siRNA: SESN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SESN1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SESN1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SESN1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SESN1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SESN1 (NM_014454)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SESN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESN1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SESN1
		Search LifeMap BioReagents cell lines for SESN1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESN1

1 GenomeRNAi human phenotype for SESN1:

Decreased TP53 protein express

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

p53 signaling pathway

p53 signaling pathway

1.00

DNA damage response

0.40

Direct p53 effectors

Direct p53 effectors

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for SESN1

	DNA damage response
	Direct p53 effectors

1 Kegg Pathway (Kegg details for SESN1):

p53 signaling pathway

SESN1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SESN1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for SESN1 (Q9Y6P5³ ENSP00000306734⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRDX1	Q06830³, ENSP00000262746⁴	I2D: score=3 STRING: ENSP00000262746
TP53	ENSP00000269305⁴	STRING: ENSP00000269305
PRDX6	ENSP00000342026⁴	STRING: ENSP00000342026
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006974	response to DNA damage stimulus	TAS	9926927
GO:0007050	cell cycle arrest	IEA	--
GO:0008285	negative regulation of cell proliferation	TAS	9926927

SESN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SESN1
Search CenterWatch for drugs/clinical trials and news about SESN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SESN1 gene (3 alternative transcripts):

NM_001199933.1 NM_001199934.1 NM_014454.2

Unigene Cluster for SESN1:

Sestrin 1

Hs.591336 [show with all ESTs]

Unigene Representative Sequence: NM_014454

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000436639(uc003psu.3) ENST00000302071(uc021zdp.1) ENST00000356644(uc003pst.4)

ENST00000520364 ENST00000368971 ENST00000523632 ENST00000517548

miRNA Products:		OriGene 3'-UTR Clone: SESN1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SESN1
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SESN1 (see all 17):
		hsa-miR-429 hsa-miR-3660 hsa-miR-15a hsa-miR-888* hsa-miR-424 hsa-miR-133a hsa-miR-200b hsa-miR-24

		SwitchGear 3'UTR luciferase reporter plasmid: SESN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SESN1 (see all 7) OriGene shRNA RFP: SESN1 OriGene siRNA: SESN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SESN1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SESN1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SESN1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SESN1 (NM_014454)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SESN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESN1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SESN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SESN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SESN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SESN1

Additional cDNA sequence:

AF033120.1 AF033121.1 AF033122.1 AJ420599.1 AK001886.1 AK290157.1 AK290551.1 AL133559.1

BC112036.1 BC113569.1

12 DOTS entries:

DT.216690 DT.95376021 DT.40311689 DT.95376020 DT.100781046 DT.121323699 DT.216688 DT.40191861

DT.92456406 DT.103130 DT.91665570 DT.100641467

24/178 AceView cDNA sequences (see all 178):

BI869714 BF221560 BU187483 BQ959573 AU136283 BI091606 AI654249 BP374526

AI360853 AA628206 AA447661 AK001886 AA502272 AF033120 AI800727 BF804346

R77970 AW149243 AI364080 AI743159 BP376528 BU790426 AI380174 AW872833

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SESN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCTGTAGA

About this image

SESN1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Trachea

Basal Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SESN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SESN1

SOURCE GeneReport for Unigene cluster: Hs.591336

UniProtKB/Swiss-Prot: SESN1_HUMAN, Q9Y6P5

Tissue specificity: Widely expressed

SABiosciences Custom PCR Arrays for SESN1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SESN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SESN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SESN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SESN1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SESN1 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sesn1^{1 , 5}	sestrin 1^{1, 5}	88.87(n)¹ 95.1(a)¹		10 (22.77 cM)⁵ 140742¹ NM_001162908.1¹ NP_001156380.1¹ 41810574⁵
chicken (Gallus gallus)	Aves	SESN1¹	sestrin 1	77.05(n) 84.43(a)		421766 XM_419796.2 XP_419796.2
lizard (Anolis carolinensis)	Reptilia	SESN1⁶	--	85(a)	1 ↔ 1	1(190908202-190922857)
African clawed frog (Xenopus laevis)	Amphibia	sesn1-A²	sestrin 1,nuclear factor XPA26-T2	78.43(n)		AB048259.1
zebrafish (Danio rerio)	Actinopterygii	sesn1¹	sestrin 1	70.75(n) 80.96(a)		436933 NM_001002660.1 NP_001002660.1
fruit fly (Drosophila melanogaster)	Insecta	Sesn⁶	Sestrin	41(a)	1 → many	2R(19601425-19620706)
worm (Caenorhabditis elegans)	Secernentea	sesn-1⁶	Sestrin homolog	24(a)	1 → many	I(27595-32482)

ENSEMBL Gene Tree for SESN1 (if available)
TreeFam Gene Tree for SESN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SESN1 gene

SESN2² SESN3²

2 SIMAP similar genes for SESN1 using alignment to 1 protein entry: SESN1_HUMAN:

SESN2 SESN3

SESN1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SESN1
PGOHUM00000240847

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2180933^1,2	H	--	109307267(+)	`GAGGAG/ATAACT`	3	--	ds500¹		4		NS EA	418
rs5879006^1,2	C,	--	109307282(+)	`GAGTTATC/-ATCAC`	3	--	ds500¹		1		CSA	2
rs141713447^1,2		--	109307295(+)	`AACAGC/GTTCAG`	3	--	ds500¹		0	--	--	--	--
rs182949695^1,2		--	109307387(+)	`GTAATG/TCTTAA`	3	--	ds500¹		0	--	--	--	--
rs113443897^1,2	C,	--	109307573(+)	`GAAAGTAGA/- TAGAT`	3	--	ds500¹		1		CSA	2
rs3834318^1,2	C	--	109307581(+)	`ATAGA-/TAGA AACTC`	3	--	ds500¹		0	--	--	--	--
rs143556195^1,2		--	109307709(+)	`ATTCAC/TGCTTC`	3	--	ut3¹		0	--	--	--	--
rs16822^1,2	C,F,O,H,	--	109307710(+)	`TTCACG/ACTTCC`	3	--	ut3¹		22		MN EA NA NS CSA WA	2806
rs187245055^1,2		--	109307774(+)	`GTTAGC/TGTTTT`	3	--	ut3¹		0	--	--	--	--
rs141786101^1,2		--	109307887(+)	`AGAGAC/TTGAAT`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SESN1 (109307640 - 109416022 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SESN1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SESN1

DNA2.0 Custom Variant and Variant Library Synthesis for SESN1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SESN1 for disorders           About GeneDecksing

OMIM gene information: 606103    OMIM disorders: --

4 diseases for SESN1:    About MalaCards

chronic fatigue syndrome prostate cancer prostatitis carcinoma

Human Genome Epidemiology (HuGE) Navigator: SESN1 (2 documents)

Export disorders for SESN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SESN1 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with SESN1)

Utopia: connect your pdf to the dynamic
world of online information

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes. (PubMed id 9926927)^{1, 2, 3, 9} Velasco-Miguel S.... Kley N. (1999)
PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. (PubMed id 12607115)^{1, 2, 9} Peeters H.... Devriendt K. (2003)
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. (PubMed id 15105503)^{1, 2} Budanov A.V.... Chumakov P.M. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes. (PubMed id 7938006)^{1, 3} Buckbinder L....Kley N. (1994)
Regulation of protein synthesis by ionizing radiation . (PubMed id 19704005)^{1, 9} Braunstein S....Schneider R.J. (2009)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Gene expression following ionising radiation: identif ication of biomarkers for dose estimation and prediction of individual response . (PubMed id 21067298)¹ Kabacik S....Badie C. (2011)
Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)¹ Flachsbart F....Nebel A. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 27244	HGNC: 21595	AceView: SESN1	Ensembl:ENSG00000080546	euGenes: HUgn27244
ECgene: SESN1	Kegg: 27244	H-InvDB: SESN1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SESN1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SESN1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SESN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SESN1 gene:
Search GeneIP for patents involving SESN1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SESN1

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ThermoFisher Antibodies for SESN1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SESN1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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SESN1 Gene

sestrin 1

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SESN1 Gene

sestrin 1

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Specialized Databases showing SESN1 gene

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for SESN1 gene

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for SESN1 gene

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for SESN1 gene

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for SESN1 gene

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Families
for SESN1 gene

Function
for SESN1 gene

Pathways & Interactions
for SESN1 gene

Drugs & Compounds
for SESN1 gene

Transcripts
for SESN1 gene

Expression
for SESN1 gene

Orthologs
for SESN1 gene

Paralogs
for SESN1 gene

Genomic Variants
for SESN1 gene

Disorders / Diseases
for SESN1 gene

Publications
for SESN1 gene

Intellectual Property
for SESN1 gene

Products
for SESN1 gene