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Aliases for SESN1 Gene

Aliases for SESN1 Gene

  • Sestrin 1 2 3 5
  • SEST1 3 4
  • PA26 3 4
  • P53 Regulated PA26 Nuclear Protein 3
  • P53-Regulated Protein PA26 4
  • P53 Activated Gene 26 3

External Ids for SESN1 Gene

Previous GeneCards Identifiers for SESN1 Gene

  • GC06M109307
  • GC06M109353
  • GC06M109414
  • GC06M106874

Summaries for SESN1 Gene

Entrez Gene Summary for SESN1 Gene

  • This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for SESN1 Gene

SESN1 (Sestrin 1) is a Protein Coding gene. Among its related pathways are Gene Expression and p53 signaling pathway. An important paralog of this gene is SESN2.

UniProtKB/Swiss-Prot for SESN1 Gene

  • Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth.

Gene Wiki entry for SESN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SESN1 Gene

Genomics for SESN1 Gene

Regulatory Elements for SESN1 Gene

Promoters for SESN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SESN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SESN1 Gene

Chromosome:
6
Start:
108,986,437 bp from pter
End:
109,094,819 bp from pter
Size:
108,383 bases
Orientation:
Minus strand

Genomic View for SESN1 Gene

Genes around SESN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SESN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SESN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SESN1 Gene

Proteins for SESN1 Gene

  • Protein details for SESN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6P5-SESN1_HUMAN
    Recommended name:
    Sestrin-1
    Protein Accession:
    Q9Y6P5
    Secondary Accessions:
    • Q2M2B7
    • Q5T316
    • Q9NV00
    • Q9UPD5
    • Q9Y6P6

    Protein attributes for SESN1 Gene

    Size:
    492 amino acids
    Molecular mass:
    56557 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SESN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SESN1 Gene

Proteomics data for SESN1 Gene at MOPED

Post-translational modifications for SESN1 Gene

  • Ubiquitination at Lys 337
  • Modification sites at PhosphoSitePlus

Other Protein References for SESN1 Gene

No data available for DME Specific Peptides for SESN1 Gene

Domains & Families for SESN1 Gene

Protein Domains for SESN1 Gene

Suggested Antigen Peptide Sequences for SESN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6P5

UniProtKB/Swiss-Prot:

SESN1_HUMAN :
  • Belongs to the sestrin family.
Family:
  • Belongs to the sestrin family.
genes like me logo Genes that share domains with SESN1: view

No data available for Gene Families for SESN1 Gene

Function for SESN1 Gene

Molecular function for SESN1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth.
UniProtKB/Swiss-Prot Induction:
Isoform T2 and isoform T3 are induced by genotoxic stress (UV, gamma-irradiation and cytotoxic drugs) in a p53/TP53-dependent manner. Isoform T1 is not induced by p53/TP53.
genes like me logo Genes that share phenotypes with SESN1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SESN1 Gene

Localization for SESN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SESN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SESN1 Gene COMPARTMENTS Subcellular localization image for SESN1 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for SESN1 Gene

Pathways & Interactions for SESN1 Gene

genes like me logo Genes that share pathways with SESN1: view

Pathways by source for SESN1 Gene

2 KEGG pathways for SESN1 Gene
1 R&D Systems pathway for SESN1 Gene

Gene Ontology (GO) - Biological Process for SESN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006974 cellular response to DNA damage stimulus TAS 9926927
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SESN1: view

No data available for SIGNOR curated interactions for SESN1 Gene

Drugs & Compounds for SESN1 Gene

No Compound Related Data Available

Transcripts for SESN1 Gene

Unigene Clusters for SESN1 Gene

Sestrin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SESN1 Gene

No ASD Table

Relevant External Links for SESN1 Gene

GeneLoc Exon Structure for
SESN1
ECgene alternative splicing isoforms for
SESN1

Expression for SESN1 Gene

mRNA expression in normal human tissues for SESN1 Gene

mRNA differential expression in normal tissues according to GTEx for SESN1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.5).

Protein differential expression in normal tissues from HIPED for SESN1 Gene

This gene is overexpressed in Testis (35.9) and Serum (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SESN1 Gene



SOURCE GeneReport for Unigene cluster for SESN1 Gene Hs.591336

mRNA Expression by UniProt/SwissProt for SESN1 Gene

Q9Y6P5-SESN1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SESN1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for SESN1 Gene

Orthologs for SESN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SESN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SESN1 36
  • 100 (a)
OneToOne
SESN1 35
  • 99.76 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia SESN1 36
  • 96 (a)
OneToOne
SESN1 35
  • 95.72 (n)
  • 97.82 (a)
dog
(Canis familiaris)
Mammalia SESN1 35
  • 93.28 (n)
  • 95.28 (a)
SESN1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sesn1 16
Sesn1 35
  • 88.87 (n)
  • 95.1 (a)
Sesn1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SESN1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SESN1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sesn1 35
  • 86.67 (n)
  • 92.69 (a)
chicken
(Gallus gallus)
Aves SESN1 35
  • 77.05 (n)
  • 84.07 (a)
SESN1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SESN1 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sesn1-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sesn1 35
  • 76.34 (n)
  • 84.84 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10916 35
zebrafish
(Danio rerio)
Actinopterygii sesn1 36
  • 74 (a)
OneToOne
sesn1 35
  • 70.82 (n)
  • 80.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sesn 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sesn-1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3472 36
  • 33 (a)
OneToMany
Species with no ortholog for SESN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SESN1 Gene

ENSEMBL:
Gene Tree for SESN1 (if available)
TreeFam:
Gene Tree for SESN1 (if available)

Paralogs for SESN1 Gene

Paralogs for SESN1 Gene

(2) SIMAP similar genes for SESN1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SESN1 Gene

genes like me logo Genes that share paralogs with SESN1: view

Variants for SESN1 Gene

Sequence variations from dbSNP and Humsavar for SESN1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2273668 - 109,002,316(+) TCCTA(G/T)TGGTC reference, missense, utr-variant-5-prime
rs440194 -- 109,006,469(+) acagg(C/G)cccgg intron-variant
rs720698 -- 109,058,811(+) CACTC(A/G)TATGA intron-variant
rs1146243 -- 109,073,819(+) ATGAA(C/T)AGAAA intron-variant
rs1260659 -- 109,077,276(+) AAAAA(A/G)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SESN1 Gene

Variant ID Type Subtype PubMed ID
nsv830768 CNV Gain 17160897
nsv886532 CNV Loss 21882294

Variation tolerance for SESN1 Gene

Residual Variation Intolerance Score: 5.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SESN1 Gene

HapMap Linkage Disequilibrium report
SESN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SESN1 Gene

Disorders for SESN1 Gene

Relevant External Links for SESN1

Genetic Association Database (GAD)
SESN1
Human Genome Epidemiology (HuGE) Navigator
SESN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SESN1

No disorders were found for SESN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SESN1 Gene

Publications for SESN1 Gene

  1. PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes. (PMID: 9926927) Velasco-Miguel S. … Kley N. (Oncogene 1999) 2 3 4 23 67
  2. Regulation of protein synthesis by ionizing radiation. (PMID: 19704005) Braunstein S. … Schneider R.J. (Mol. Cell. Biol. 2009) 3 23
  3. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. (PMID: 12607115) Peeters H. … Devriendt K. (Hum. Genet. 2003) 3 23
  4. Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes. (PMID: 7938006) Buckbinder L. … Kley N. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3
  5. Rapamycin attenuates endothelial apoptosis induced by low shear stress via mTOR and sestrin1 related redox regulation. (PMID: 24587596) Zhang J. … Chen S. (Mediators Inflamm. 2014) 3

Products for SESN1 Gene

Sources for SESN1 Gene

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