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Aliases for SERTAD4 Gene

Aliases for SERTAD4 Gene

  • SERTA Domain Containing 4 2 3 5
  • DJ667H12.2 3

External Ids for SERTAD4 Gene

Previous GeneCards Identifiers for SERTAD4 Gene

  • GC01P207486
  • GC01P206794
  • GC01P208472
  • GC01P210406
  • GC01P181079

Summaries for SERTAD4 Gene

GeneCards Summary for SERTAD4 Gene

SERTAD4 (SERTA Domain Containing 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERTAD4 Gene

Genomics for SERTAD4 Gene

Regulatory Elements for SERTAD4 Gene

Promoters for SERTAD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SERTAD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERTAD4 Gene

Chromosome:
1
Start:
210,232,799 bp from pter
End:
210,246,858 bp from pter
Size:
14,060 bases
Orientation:
Plus strand

Genomic View for SERTAD4 Gene

Genes around SERTAD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERTAD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERTAD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTAD4 Gene

Proteins for SERTAD4 Gene

  • Protein details for SERTAD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUC0-SRTD4_HUMAN
    Recommended name:
    SERTA domain-containing protein 4
    Protein Accession:
    Q9NUC0
    Secondary Accessions:
    • B2RD32

    Protein attributes for SERTAD4 Gene

    Size:
    356 amino acids
    Molecular mass:
    39348 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERTAD4 Gene

Proteomics data for SERTAD4 Gene at MOPED

Post-translational modifications for SERTAD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERTAD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERTAD4 Gene

Domains & Families for SERTAD4 Gene

Protein Domains for SERTAD4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERTAD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUC0

UniProtKB/Swiss-Prot:

SRTD4_HUMAN :
  • Contains 1 SERTA domain.
Domain:
  • Contains 1 SERTA domain.
genes like me logo Genes that share domains with SERTAD4: view

No data available for Gene Families for SERTAD4 Gene

Function for SERTAD4 Gene

Phenotypes for SERTAD4 Gene

genes like me logo Genes that share phenotypes with SERTAD4: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERTAD4 Gene

Localization for SERTAD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERTAD4 Gene COMPARTMENTS Subcellular localization image for SERTAD4 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SERTAD4 Gene

Pathways & Interactions for SERTAD4 Gene

SuperPathways for SERTAD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERTAD4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SERTAD4 Gene

Drugs & Compounds for SERTAD4 Gene

No Compound Related Data Available

Transcripts for SERTAD4 Gene

Unigene Clusters for SERTAD4 Gene

SERTA domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: -
SP2: -
SP3:
SP4: - - -
SP5: -

Relevant External Links for SERTAD4 Gene

GeneLoc Exon Structure for
SERTAD4
ECgene alternative splicing isoforms for
SERTAD4

Expression for SERTAD4 Gene

mRNA expression in normal human tissues for SERTAD4 Gene

SOURCE GeneReport for Unigene cluster for SERTAD4 Gene Hs.600545

genes like me logo Genes that share expression patterns with SERTAD4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SERTAD4 Gene

Orthologs for SERTAD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERTAD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERTAD4 35
  • 93.04 (n)
  • 92.17 (a)
SERTAD4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERTAD4 36
  • 95 (a)
OneToOne
SERTAD4 35
  • 92.52 (n)
  • 93.75 (a)
dog
(Canis familiaris)
Mammalia SERTAD4 35
  • 92.77 (n)
  • 92.11 (a)
SERTAD4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sertad4 16
Sertad4 36
  • 76 (a)
OneToOne
Sertad4 35
  • 82.34 (n)
  • 80.17 (a)
oppossum
(Monodelphis domestica)
Mammalia SERTAD4 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERTAD4 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sertad4 35
  • 81.87 (n)
  • 80.45 (a)
chicken
(Gallus gallus)
Aves SERTAD4 35
  • 71.1 (n)
  • 70.86 (a)
-- 36
  • 66 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SERTAD4 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sertad4 35
  • 65.86 (n)
  • 57.53 (a)
zebrafish
(Danio rerio)
Actinopterygii SERTAD4 36
  • 32 (a)
OneToOne
Species with no ortholog for SERTAD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERTAD4 Gene

ENSEMBL:
Gene Tree for SERTAD4 (if available)
TreeFam:
Gene Tree for SERTAD4 (if available)

Paralogs for SERTAD4 Gene

Pseudogenes.org Pseudogenes for SERTAD4 Gene

genes like me logo Genes that share paralogs with SERTAD4: view

No data available for Paralogs for SERTAD4 Gene

Variants for SERTAD4 Gene

Sequence variations from dbSNP and Humsavar for SERTAD4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs701944 -- 210,243,753(-) ACAGG(C/T)CCAAG intron-variant, nc-transcript-variant
rs845452 -- 210,244,516(+) CATTC(C/T)ATACA intron-variant, nc-transcript-variant
rs1338295 -- 210,239,658(-) TGTTA(A/C)TAAGT intron-variant
rs1342134 -- 210,247,193(-) CACTG(C/T)GTCTA downstream-variant-500B
rs4844982 -- 210,243,092(+) ACAGG(A/C)Caaaa intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SERTAD4 Gene

Variant ID Type Subtype PubMed ID
nsv8769 CNV Gain 18304495

Variation tolerance for SERTAD4 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERTAD4 Gene

HapMap Linkage Disequilibrium report
SERTAD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERTAD4 Gene

Disorders for SERTAD4 Gene

Relevant External Links for SERTAD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERTAD4

No disorders were found for SERTAD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERTAD4 Gene

Publications for SERTAD4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. (PMID: 20368287) Pilot-Storck F. … Goillot E. (Mol. Cell Proteomics 2010) 3
  5. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. (PMID: 19156129) Glatter T. … Gstaiger M. (Mol. Syst. Biol. 2009) 3

Products for SERTAD4 Gene

Sources for SERTAD4 Gene

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