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Aliases for SERTAD4 Gene

Aliases for SERTAD4 Gene

  • SERTA Domain Containing 4 2 3 5
  • SERTA Domain-Containing Protein 4 3
  • DJ667H12.2 3

External Ids for SERTAD4 Gene

Previous GeneCards Identifiers for SERTAD4 Gene

  • GC01P207486
  • GC01P206794
  • GC01P208472
  • GC01P210406
  • GC01P181079

Summaries for SERTAD4 Gene

GeneCards Summary for SERTAD4 Gene

SERTAD4 (SERTA Domain Containing 4) is a Protein Coding gene.

Additional gene information for SERTAD4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERTAD4 Gene

Genomics for SERTAD4 Gene

Regulatory Elements for SERTAD4 Gene

Enhancers for SERTAD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H210371 1.4 Ensembl ENCODE 13.8 +140.9 140864 3 HNRNPUL1 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RCOR3 SERTAD4-AS1 SERTAD4 ST13P19 DIEXF HHAT GC01M210375 RNU5A-8P PIR50724
GH01H210259 1.1 VISTA Ensembl ENCODE 11.2 +29.1 29094 4 ZFHX2 POLR2A HLF ZSCAN4 ZNF600 EGR2 SERTAD4-AS1 SERTAD4 TRAF3IP3 IRF6 ST13P19 GC01P210243
GH01H210342 1.1 Ensembl ENCODE 10.9 +110.8 110790 1 HDGF PKNOX1 BMI1 YBX1 ZNF2 ZNF366 ATF7 IKZF2 EGR2 REST SERTAD4-AS1 TRAF3IP3 RCOR3 RNU5A-8P SERTAD4 HHAT PIR50724
GH01H210331 1.1 FANTOM5 ENCODE 9.8 +99.9 99877 1 PKNOX1 BATF SCRT2 ATF7 ETV6 RUNX3 IKZF2 CREM SP3 CBFB SERTAD4-AS1 HHAT SERTAD4 PIR50724
GH01H210328 1 ENCODE 9.8 +96.1 96147 1 HDGF ZNF133 SIN3A DMAP1 YY1 ZNF121 GLIS2 ZNF143 ZNF207 ATF7 SERTAD4-AS1 RCOR3 SERTAD4 HHAT PIR50724
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERTAD4 on UCSC Golden Path with GeneCards custom track

Promoters for SERTAD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000019455 401 2001 ZSCAN4 ZNF76 KLF17 ZNF2 ZEB1 GLIS2 EGR1 ZNF366 FOS RCOR1

Genomic Location for SERTAD4 Gene

Chromosome:
1
Start:
210,232,799 bp from pter
End:
210,246,858 bp from pter
Size:
14,060 bases
Orientation:
Plus strand

Genomic View for SERTAD4 Gene

Genes around SERTAD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERTAD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERTAD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTAD4 Gene

Proteins for SERTAD4 Gene

  • Protein details for SERTAD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUC0-SRTD4_HUMAN
    Recommended name:
    SERTA domain-containing protein 4
    Protein Accession:
    Q9NUC0
    Secondary Accessions:
    • B2RD32

    Protein attributes for SERTAD4 Gene

    Size:
    356 amino acids
    Molecular mass:
    39348 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERTAD4 Gene

Post-translational modifications for SERTAD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERTAD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERTAD4 Gene

Domains & Families for SERTAD4 Gene

Gene Families for SERTAD4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SERTAD4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERTAD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SERTAD4: view

No data available for UniProtKB/Swiss-Prot for SERTAD4 Gene

Function for SERTAD4 Gene

genes like me logo Genes that share phenotypes with SERTAD4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SERTAD4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERTAD4 Gene

Localization for SERTAD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERTAD4 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SERTAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SERTAD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SERTAD4 Gene

Pathways & Interactions for SERTAD4 Gene

SuperPathways for SERTAD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERTAD4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SERTAD4 Gene

Drugs & Compounds for SERTAD4 Gene

No Compound Related Data Available

Transcripts for SERTAD4 Gene

Unigene Clusters for SERTAD4 Gene

SERTA domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SERTAD4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: -
SP2: -
SP3:
SP4: - - -
SP5: -

Relevant External Links for SERTAD4 Gene

GeneLoc Exon Structure for
SERTAD4
ECgene alternative splicing isoforms for
SERTAD4

Expression for SERTAD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERTAD4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERTAD4 Gene:

SERTAD4

SOURCE GeneReport for Unigene cluster for SERTAD4 Gene:

Hs.600545

Evidence on tissue expression from TISSUES for SERTAD4 Gene

  • Kidney(4.4)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SERTAD4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERTAD4 Gene

Orthologs for SERTAD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERTAD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERTAD4 33 34
  • 93.04 (n)
dog
(Canis familiaris)
Mammalia SERTAD4 33 34
  • 92.77 (n)
cow
(Bos Taurus)
Mammalia SERTAD4 33 34
  • 92.52 (n)
mouse
(Mus musculus)
Mammalia Sertad4 33 16 34
  • 82.34 (n)
rat
(Rattus norvegicus)
Mammalia Sertad4 33
  • 81.87 (n)
oppossum
(Monodelphis domestica)
Mammalia SERTAD4 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERTAD4 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 86 (a)
OneToMany
SERTAD4 33
  • 71.1 (n)
-- 34
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SERTAD4 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sertad4 33
  • 65.86 (n)
zebrafish
(Danio rerio)
Actinopterygii SERTAD4 34
  • 32 (a)
OneToOne
Species where no ortholog for SERTAD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERTAD4 Gene

ENSEMBL:
Gene Tree for SERTAD4 (if available)
TreeFam:
Gene Tree for SERTAD4 (if available)

Paralogs for SERTAD4 Gene

Pseudogenes.org Pseudogenes for SERTAD4 Gene

genes like me logo Genes that share paralogs with SERTAD4: view

No data available for Paralogs for SERTAD4 Gene

Variants for SERTAD4 Gene

Sequence variations from dbSNP and Humsavar for SERTAD4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000007696 -- 210,245,529(+) GGGAC(A/G)TGGGA intron-variant, nc-transcript-variant
rs1000040339 -- 210,245,835(+) ATGAC(C/T)ATTAA nc-transcript-variant, reference, synonymous-codon
rs1000218512 -- 210,239,002(+) TTTTG(-/A)AAAAA intron-variant
rs1000315699 -- 210,233,107(+) GGGCA(C/G)CCACG intron-variant
rs1000507934 -- 210,240,526(+) AGTTC(A/C)CAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERTAD4 Gene

Variant ID Type Subtype PubMed ID
nsv1068469 CNV deletion 25765185
nsv1121788 CNV deletion 24896259
nsv8769 CNV gain 18304495

Variation tolerance for SERTAD4 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERTAD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERTAD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERTAD4 Gene

Disorders for SERTAD4 Gene

Relevant External Links for SERTAD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERTAD4

No disorders were found for SERTAD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERTAD4 Gene

Publications for SERTAD4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for SERTAD4 Gene

Sources for SERTAD4 Gene

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