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Aliases for SERTAD3 Gene

Aliases for SERTAD3 Gene

  • SERTA Domain Containing 3 2 3 5
  • RPA-Binding Trans-Activator 2 3 4
  • Replication Protein-Binding Trans-Activator 3 4
  • RBT1 3 4
  • SERTA Domain-Containing Protein 3 3

External Ids for SERTAD3 Gene

Previous GeneCards Identifiers for SERTAD3 Gene

  • GC19M045639
  • GC19M045640
  • GC19M040946
  • GC19M037383

Summaries for SERTAD3 Gene

Entrez Gene Summary for SERTAD3 Gene

  • The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SERTAD3 Gene

SERTAD3 (SERTA Domain Containing 3) is a Protein Coding gene. Diseases associated with SERTAD3 include Amyotrophic Lateral Sclerosis 1.

UniProtKB/Swiss-Prot for SERTAD3 Gene

  • Strong transcriptional coactivator.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERTAD3 Gene

Genomics for SERTAD3 Gene

Regulatory Elements for SERTAD3 Gene

Enhancers for SERTAD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G040441 1.4 ENCODE dbSUPER 37.8 +0.5 457 5.4 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC EID2B SERTAD3 ENSG00000205041 ENSG00000269069 SNRPA ENSG00000269843 ZNF546 HIPK4 FBL ITPKC
GH19G040431 2 FANTOM5 Ensembl ENCODE dbSUPER 25.9 +11.0 10965 3.6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF548 ENSG00000205041 SERTAD3 EID2B ENSG00000269843 SNRPA ENSG00000269069 NUMBL EID2 SERTAD1 LOC105372489
GH19G040462 1.5 FANTOM5 ENCODE 31.2 -20.5 -20508 4.5 CREB3L1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ENSG00000269843 SNRPA ENSG00000205041 SERTAD3 ENSG00000269069 SERTAD1 ITPKC FBL NUMBL COQ8B
GH19G040420 2 FANTOM5 Ensembl ENCODE dbSUPER 22.1 +21.1 21128 6.6 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SERTAD3 SNRPA PSMC4 FBL CCDC97 ITPKC ENSG00000269843 EID2B PRX SERTAD1
GH19G040415 2 FANTOM5 Ensembl ENCODE dbSUPER 16.5 +27.6 27614 2.8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 SNRPA SERTAD3 FBL PRX CCDC97 ITPKC ENSG00000269843 EID2B PSMC4 NUMBL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERTAD3 on UCSC Golden Path with GeneCards custom track

Promoters for SERTAD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109529 705 2401 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC

Genomic Location for SERTAD3 Gene

Chromosome:
19
Start:
40,440,841 bp from pter
End:
40,444,705 bp from pter
Size:
3,865 bases
Orientation:
Minus strand

Genomic View for SERTAD3 Gene

Genes around SERTAD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERTAD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERTAD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTAD3 Gene

Proteins for SERTAD3 Gene

  • Protein details for SERTAD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJW9-SRTD3_HUMAN
    Recommended name:
    SERTA domain-containing protein 3
    Protein Accession:
    Q9UJW9
    Secondary Accessions:
    • B3KQB3
    • Q96CQ2

    Protein attributes for SERTAD3 Gene

    Size:
    196 amino acids
    Molecular mass:
    21769 Da
    Quaternary structure:
    • Interacts with RPA2.

neXtProt entry for SERTAD3 Gene

Post-translational modifications for SERTAD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERTAD3 Gene

No data available for DME Specific Peptides for SERTAD3 Gene

Domains & Families for SERTAD3 Gene

Protein Domains for SERTAD3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERTAD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SERTAD3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SERTAD3 Gene

Function for SERTAD3 Gene

Molecular function for SERTAD3 Gene

UniProtKB/Swiss-Prot Function:
Strong transcriptional coactivator.

Gene Ontology (GO) - Molecular Function for SERTAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10982866
genes like me logo Genes that share ontologies with SERTAD3: view
genes like me logo Genes that share phenotypes with SERTAD3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERTAD3 Gene

Localization for SERTAD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERTAD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERTAD3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SERTAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 10982866
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SERTAD3: view

Pathways & Interactions for SERTAD3 Gene

SuperPathways for SERTAD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERTAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA,IEA 10982866
GO:0030308 negative regulation of cell growth IDA 16098148
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SERTAD3: view

No data available for Pathways by source and SIGNOR curated interactions for SERTAD3 Gene

Drugs & Compounds for SERTAD3 Gene

No Compound Related Data Available

Transcripts for SERTAD3 Gene

Unigene Clusters for SERTAD3 Gene

SERTA domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5:

Relevant External Links for SERTAD3 Gene

GeneLoc Exon Structure for
SERTAD3
ECgene alternative splicing isoforms for
SERTAD3

Expression for SERTAD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERTAD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERTAD3 Gene:

SERTAD3

SOURCE GeneReport for Unigene cluster for SERTAD3 Gene:

Hs.515412
genes like me logo Genes that share expression patterns with SERTAD3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERTAD3 Gene

Orthologs for SERTAD3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SERTAD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERTAD3 34 35
  • 99.83 (n)
cow
(Bos Taurus)
Mammalia SERTAD3 34 35
  • 88.78 (n)
dog
(Canis familiaris)
Mammalia SERTAD3 34 35
  • 88.21 (n)
rat
(Rattus norvegicus)
Mammalia Sertad3 34
  • 84.1 (n)
mouse
(Mus musculus)
Mammalia Sertad3 34 16 35
  • 83.76 (n)
Species where no ortholog for SERTAD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERTAD3 Gene

ENSEMBL:
Gene Tree for SERTAD3 (if available)
TreeFam:
Gene Tree for SERTAD3 (if available)

Paralogs for SERTAD3 Gene

No data available for Paralogs for SERTAD3 Gene

Variants for SERTAD3 Gene

Sequence variations from dbSNP and Humsavar for SERTAD3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000655884 -- 40,441,150(+) CCCAG(-/CTTT)CTTTA utr-variant-3-prime
rs1000760729 -- 40,446,330(+) CAAAA(C/T)CTGCG upstream-variant-2KB
rs1001386106 -- 40,444,780(+) GAAGA(C/G)CAGCC intron-variant, upstream-variant-2KB
rs1001534190 -- 40,442,124(+) AGACA(C/T)CAGAC intron-variant, upstream-variant-2KB
rs1001560658 -- 40,441,832(+) CCCAG(A/G)AAGAG upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SERTAD3 Gene

Variant ID Type Subtype PubMed ID
nsv819017 CNV loss 19587683
nsv833831 CNV loss 17160897

Variation tolerance for SERTAD3 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERTAD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERTAD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERTAD3 Gene

Disorders for SERTAD3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SERTAD3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SERTAD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERTAD3
genes like me logo Genes that share disorders with SERTAD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERTAD3 Gene

Publications for SERTAD3 Gene

  1. RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A. (PMID: 10982866) Cho J.M. … Alaoui-Jamali M.A. (Nucleic Acids Res. 2000) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. TRIP-Br: a novel family of PHD zinc finger- and bromodomain- interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PMID: 11331592) Hsu S.-I. … Bonventre J.V. (EMBO J. 2001) 2 3 64
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for SERTAD3 Gene

Sources for SERTAD3 Gene

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