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Aliases for SERTAD3 Gene

Aliases for SERTAD3 Gene

  • SERTA Domain Containing 3 2 3 5
  • RPA-Binding Trans-Activator 2 3 4
  • Replication Protein-Binding Trans-Activator 3 4
  • RBT1 3 4
  • SERTA Domain-Containing Protein 3 3

External Ids for SERTAD3 Gene

Previous GeneCards Identifiers for SERTAD3 Gene

  • GC19M045639
  • GC19M045640
  • GC19M040946
  • GC19M037383

Summaries for SERTAD3 Gene

Entrez Gene Summary for SERTAD3 Gene

  • The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SERTAD3 Gene

SERTAD3 (SERTA Domain Containing 3) is a Protein Coding gene. Diseases associated with SERTAD3 include Amyotrophic Lateral Sclerosis 1.

UniProtKB/Swiss-Prot for SERTAD3 Gene

  • Strong transcriptional coactivator.

Additional gene information for SERTAD3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERTAD3 Gene

Genomics for SERTAD3 Gene

Regulatory Elements for SERTAD3 Gene

Enhancers for SERTAD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H040420 2 FANTOM5 Ensembl ENCODE dbSUPER 30.6 +21.1 21128 6.6 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 HNRNPUL1 CCDC97 SERTAD3 ITPKC SNRPA FBL AKT2 ENSG00000269843 SUPT5H CYP2T1P
GH19H040441 1.4 ENCODE dbSUPER 37.8 +0.5 457 5.4 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 HNRNPUL1 SERTAD3 SNRPA ENSG00000269843 CYP2F2P CCDC97 FBL PSMC4 ZNF780B ENSG00000271299
GH19H040431 2 FANTOM5 Ensembl ENCODE dbSUPER 25.9 +11.0 10965 3.6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF548 SERTAD3 HNRNPUL1 ENSG00000269843 SNRPA SERTAD1 ENSG00000277453 LOC105372489
GH19H040462 1.5 FANTOM5 ENCODE 31.2 -20.5 -20508 4.5 FEZF1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC GLIS1 RCOR2 NBN ENSG00000269843 SNRPA HNRNPUL1 ZNF780B AKT2 SERTAD3 CYP2G1P CCDC97 FBL ITPKC
GH19H040415 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.5 +27.6 27614 2.8 HDGF PKNOX1 FOXA2 ARNT ARID4B ZNF143 FOS SP3 SP5 JUNB SNRPA HNRNPUL1 FBL CCDC97 ENSG00000269843 ITPKC AKT2 SERTAD3 PRX COQ8B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERTAD3 on UCSC Golden Path with GeneCards custom track

Promoters for SERTAD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109529 705 2401 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1

Genomic Locations for SERTAD3 Gene

Genomic Locations for SERTAD3 Gene
chr19:40,440,841-40,444,705
(GRCh38/hg38)
Size:
3,865 bases
Orientation:
Minus strand
chr19:40,946,748-40,950,612
(GRCh37/hg19)

Genomic View for SERTAD3 Gene

Genes around SERTAD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERTAD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERTAD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTAD3 Gene

Proteins for SERTAD3 Gene

  • Protein details for SERTAD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJW9-SRTD3_HUMAN
    Recommended name:
    SERTA domain-containing protein 3
    Protein Accession:
    Q9UJW9
    Secondary Accessions:
    • B3KQB3
    • Q96CQ2

    Protein attributes for SERTAD3 Gene

    Size:
    196 amino acids
    Molecular mass:
    21769 Da
    Quaternary structure:
    • Interacts with RPA2.

neXtProt entry for SERTAD3 Gene

Post-translational modifications for SERTAD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERTAD3 Gene

No data available for DME Specific Peptides for SERTAD3 Gene

Domains & Families for SERTAD3 Gene

Gene Families for SERTAD3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SERTAD3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERTAD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SERTAD3: view

No data available for UniProtKB/Swiss-Prot for SERTAD3 Gene

Function for SERTAD3 Gene

Molecular function for SERTAD3 Gene

UniProtKB/Swiss-Prot Function:
Strong transcriptional coactivator.

Phenotypes From GWAS Catalog for SERTAD3 Gene

Gene Ontology (GO) - Molecular Function for SERTAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10982866
genes like me logo Genes that share ontologies with SERTAD3: view
genes like me logo Genes that share phenotypes with SERTAD3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERTAD3 Gene

Localization for SERTAD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERTAD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERTAD3 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SERTAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 10982866
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SERTAD3: view

Pathways & Interactions for SERTAD3 Gene

SuperPathways for SERTAD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERTAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA,IEA 10982866
GO:0030308 negative regulation of cell growth IDA 16098148
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SERTAD3: view

No data available for Pathways by source and SIGNOR curated interactions for SERTAD3 Gene

Drugs & Compounds for SERTAD3 Gene

No Compound Related Data Available

Transcripts for SERTAD3 Gene

Unigene Clusters for SERTAD3 Gene

SERTA domain containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5:

Relevant External Links for SERTAD3 Gene

GeneLoc Exon Structure for
SERTAD3
ECgene alternative splicing isoforms for
SERTAD3

Expression for SERTAD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERTAD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERTAD3 Gene:

SERTAD3

SOURCE GeneReport for Unigene cluster for SERTAD3 Gene:

Hs.515412
genes like me logo Genes that share expression patterns with SERTAD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERTAD3 Gene

Orthologs for SERTAD3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SERTAD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERTAD3 33 34
  • 99.83 (n)
cow
(Bos Taurus)
Mammalia SERTAD3 33 34
  • 88.78 (n)
dog
(Canis familiaris)
Mammalia SERTAD3 33 34
  • 88.21 (n)
rat
(Rattus norvegicus)
Mammalia Sertad3 33
  • 84.1 (n)
mouse
(Mus musculus)
Mammalia Sertad3 33 16 34
  • 83.76 (n)
Species where no ortholog for SERTAD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERTAD3 Gene

ENSEMBL:
Gene Tree for SERTAD3 (if available)
TreeFam:
Gene Tree for SERTAD3 (if available)

Paralogs for SERTAD3 Gene

No data available for Paralogs for SERTAD3 Gene

Variants for SERTAD3 Gene

Sequence variations from dbSNP and Humsavar for SERTAD3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000655884 -- 40,441,150(+) CCCAG(-/CTTT)CTTTA utr-variant-3-prime
rs1000760729 -- 40,446,330(+) CAAAA(C/T)CTGCG upstream-variant-2KB
rs1001386106 -- 40,444,780(+) GAAGA(C/G)CAGCC intron-variant, upstream-variant-2KB
rs1001534190 -- 40,442,124(+) AGACA(C/T)CAGAC intron-variant, upstream-variant-2KB
rs1001560658 -- 40,441,832(+) CCCAG(A/G)AAGAG upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SERTAD3 Gene

Variant ID Type Subtype PubMed ID
nsv819017 CNV loss 19587683
nsv833831 CNV loss 17160897

Variation tolerance for SERTAD3 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERTAD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERTAD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERTAD3 Gene

Disorders for SERTAD3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SERTAD3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SERTAD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERTAD3
genes like me logo Genes that share disorders with SERTAD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERTAD3 Gene

Publications for SERTAD3 Gene

  1. RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A. (PMID: 10982866) Cho JM … Alaoui-Jamali MA (Nucleic acids research 2000) 2 3 4 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PMID: 11331592) Hsu SI … Bonventre JV (The EMBO journal 2001) 2 3 60
  4. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 60
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 60

Products for SERTAD3 Gene

Sources for SERTAD3 Gene

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