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SERTAD3 Gene

protein-coding   GIFtS: 48
GCID: GC19M040946

SERTA Domain Containing 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SERTA Domain Containing 31 2
RPA-Binding Trans-Activator1 2 3
RBT12 3 5
Replication Protein-Binding Trans-Activator2 3
SERTA Domain-Containing Protein 32

External Ids:    HGNC: 179311   Entrez Gene: 299462   Ensembl: ENSG000001675657   OMIM: 6121255   UniProtKB: Q9UJW93   

Export aliases for SERTAD3 gene to outside databases

Previous GC identifers: GC19M045639 GC19M045640 GC19M037383


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SERTAD3 Gene:
The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human
replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in
cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional
co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same
protein, have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for SERTAD3 Gene:
SERTAD3 (SERTA domain containing 3) is a protein-coding gene. Diseases associated with SERTAD3 include transitional cell carcinoma.

UniProtKB/Swiss-Prot: SRTD3_HUMAN, Q9UJW9
Function: Strong transcriptional coactivator




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERTAD3 gene promoter:
         Bach1   IRF-2   p53   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERTAD3 promoter sequence
   Search Chromatin IP Primers for SERTAD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERTAD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

SERTAD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERTAD3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M040946:  view genomic region     (about GC identifiers)

Start:
40,946,748 bp from pter      End:
40,950,612 bp from pter
Size:
3,865 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SRTD3_HUMAN, Q9UJW9 (See protein sequence)
Recommended Name: SERTA domain-containing protein 3  
Size: 196 amino acids; 21769 Da
Subunit: Interacts with RPA2
Secondary accessions: B3KQB3 Q96CQ2

Explore the universe of human proteins at neXtProt for SERTAD3: NX_Q9UJW9

Explore proteomics data for SERTAD3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SERTAD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_037500.2  NP_976219.1  

    ENSEMBL proteins: 
     ENSP00000375882   ENSP00000325414   ENSP00000469245   ENSP00000472999  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009263 SERTA

    Graphical View of Domain Structure for InterPro Entry Q9UJW9

    ProtoNet protein and cluster: Q9UJW9

    UniProtKB/Swiss-Prot: SRTD3_HUMAN, Q9UJW9
    Similarity: Contains 1 SERTA domain


    SERTAD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRTD3_HUMAN, Q9UJW9
    Function: Strong transcriptional coactivator

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10982866
         
    SERTAD3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERTAD3
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    miRNA
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    miRTarBase miRNAs that target SERTAD3:
    hsa-mir-25-3p (MIRT050344), hsa-mir-92a-3p (MIRT049827), hsa-mir-18a-5p (MIRT031339), hsa-mir-7-5p (MIRT025961)

    Block miRNA regulation of human, mouse, rat SERTAD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERTAD3 (see all 20):
    hsa-miR-485-5p hsa-miR-3910 hsa-miR-125a-5p hsa-miR-25 hsa-miR-3190 hsa-miR-141* hsa-miR-124 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidSERTAD3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SERTAD3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERTAD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRTD3_HUMAN, Q9UJW9: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10982866

    SERTAD3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERTAD3
    Interactions:

        GeneGlobe Interaction Network for SERTAD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for SERTAD3 (Q9UJW91, 3 ENSP000003254144) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USHBP1Q8N6Y01, 3, ENSP000002525974EBI-748621,EBI-739895 I2D: score=4 STRING: ENSP00000252597
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    RPA2P159273, ENSP000003630214I2D: score=2 STRING: ENSP00000363021
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    IGHA1P018763, ENSP000003749894I2D: score=1 STRING: ENSP00000374989
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA10982866
    GO:0030308negative regulation of cell growth IDA16098148
    GO:0045893positive regulation of transcription, DNA-templated IEA--

    SERTAD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERTAD3 (SRTD3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SERTAD3 gene (2 alternative transcripts): 
    NM_013368.3  NM_203344.2  

    Unigene Cluster for SERTAD3:

    SERTA domain containing 3
    Hs.515412  [show with all ESTs]
    Unigene Representative Sequence: AF192529
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392028(uc002onu.4) ENST00000322354(uc002onv.4) ENST00000601217
    ENST00000599706 ENST00000596456
    miRNA
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    Block miRNA regulation of human, mouse, rat SERTAD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERTAD3 (see all 20):
    hsa-miR-485-5p hsa-miR-3910 hsa-miR-125a-5p hsa-miR-25 hsa-miR-3190 hsa-miR-141* hsa-miR-124 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidSERTAD3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): SERTAD3 (NM_203344)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERTAD3
    Primer
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    OriGene qPCR primer pairs and template standards for SERTAD3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERTAD3
      QuantiTect SYBR Green Assays in human, mouse, rat SERTAD3
      QuantiFast Probe-based Assays in human, mouse, rat SERTAD3

    Additional mRNA sequence: 

    AF192529.1 AK074604.1 BC014061.2 BC050643.2 

    4 DOTS entries:

    DT.91703917  DT.97815097  DT.97773080  DT.100639352 

    Selected AceView cDNA sequences (see all 83):

    BC014061 CR601245 BM848331 BM841068 CR605181 AI494186 BE745396 BU157342 
    NM_203344 AK074604 BM546306 BX113979 BC050643 BU149415 BG720189 AA482559 
    BX398356 BI223874 CB995481 BX362282 BX362283 AL043629 AF192529 BG105954 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
    SP1:                    -     -                                 
    SP2:                    -     -     -                           
    SP3:                    -     -     -     -                     
    SP4:                          -     -     -                     
    SP5:                                                            


    ECgene alternative splicing isoforms for SERTAD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERTAD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGGGTTATT
    SERTAD3 Expression
    About this image

    SERTAD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERTAD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515412
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERTAD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SERTAD3 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sertad31 , 5 SERTA domain containing 31, 5 83.76(n)1
    85.64(a)1
      7 (15.91 cM)5
    1707421  NM_133210.21  NP_573473.11 
     274738405 


    ENSEMBL Gene Tree for SERTAD3 (if available)
    TreeFam Gene Tree for SERTAD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERTAD3 (see all 78)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406804461,2
    --40946380(+) GCACTA/GATTTT 2 -- ds50010--------
    rs1456843171,2
    --40946424(+) GCTTAC/TTGCAG 2 -- ds50010--------
    rs2015152491,2
    --40946527(+) TTGTA-/GAG   
       GCAGT
    GTTTC
    2 -- ds50010--------
    rs1879920801,2
    --40946539(+) TGTTTC/TGCCAC 2 -- ds50010--------
    rs81095441,2
    C,F--40946557(+) aggctG/Agcctc 2 -- ds50013Minor allele frequency- A:0.17NA WA 6
    rs1383629171,2
    --40946568(+) AAGCAA/GATCCT 2 -- ds50010--------
    rs104191821,2
    C,A--40946682(+) TGGTGC/GTGATG 2 -- ds50010--------
    rs1495620301,2
    C--40946763(+) CAAAAC/TACTTT 2 -- ut310--------
    rs1129246891,2
    C--40946794(+) AATCC-/AAAAA 
            
    AAAAA
    2 -- ut311Minor allele frequency- AAAAA:0.00CSA 2
    rs559936981,2
    C--40946809(+) AAAAA-/A/AAAA
            
    GCCAC
    4 -- ut311NA 2

    HapMap Linkage Disequilibrium report for SERTAD3 (40946748 - 40950612 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SERTAD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819017CNV Loss19587683
    dgv3867n71CNV Loss21882294
    nsv911709CNV Loss21882294
    nsv833831CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612125    OMIM disorders: --

    1 disease for SERTAD3:    About MalaCards
    transitional cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for SERTAD3:
    Transitional cell carcinoma

    SERTAD3 for disorders           About GeneDecksing


    Export disorders for SERTAD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERTAD3 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with SERTAD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A. (PubMed id 10982866)1, 2, 3, 9 Cho J.M....Alaoui-Jamali M.A. (Nucleic Acids Res. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. TRIP-Br: a novel family of PHD zinc finger- and bromodomain- interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PubMed id 11331592)1, 3 Hsu S.-I....Bonventre J.V. (EMBO J. 2001)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
    6. Overexpression of SERTAD3, a putative oncogene located within the 19q13 amplicon, induces E2F activity and promotes tumor growth. (PubMed id 17260023)1 Darwish H....Alaoui-Jamali M.A. (Oncogene 2007)
    7. SEI family of nuclear factors regulates p53-dependent transcriptional activation. (PubMed id 16098148)1 Watanabe-Fukunaga R....Fukunaga R. (amp 2005)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. An investigation into the human serum &quot;interactome&quot;. (PubMed id 15174051)1 Zhou M....Conrads T.P. (Electrophoresis 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29946 HGNC: 17931 AceView: SERTAD3 Ensembl:ENSG00000167565 euGenes: HUgn29946
    ECgene: SERTAD3 H-InvDB: SERTAD3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERTAD3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERTAD3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERTAD3 gene:
    Search GeneIP for patents involving SERTAD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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