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Aliases for SERTAD3 Gene

Aliases for SERTAD3 Gene

  • SERTA Domain Containing 3 2 3
  • RPA-Binding Trans-Activator 2 3 4
  • RBT1 3 4 6
  • Replication Protein-Binding Trans-Activator 3 4
  • SERTA Domain-Containing Protein 3 3

External Ids for SERTAD3 Gene

Summaries for SERTAD3 Gene

Entrez Gene Summary for SERTAD3 Gene

  • The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SERTAD3 Gene

SERTAD3 (SERTA Domain Containing 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SERTAD3 Gene

  • Strong transcriptional coactivator.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERTAD3 Gene

Genomics for SERTAD3 Gene

Genomic Location for SERTAD3 Gene

Start:
40,440,841 bp from pter
End:
40,444,705 bp from pter
Size:
3,865 bases
Orientation:
Minus strand

Genomic View for SERTAD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERTAD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTAD3 Gene

Regulatory Elements for SERTAD3 Gene

Proteins for SERTAD3 Gene

  • Protein details for SERTAD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJW9-SRTD3_HUMAN
    Recommended name:
    SERTA domain-containing protein 3
    Protein Accession:
    Q9UJW9
    Secondary Accessions:
    • B3KQB3
    • Q96CQ2

    Protein attributes for SERTAD3 Gene

    Size:
    196 amino acids
    Molecular mass:
    21769 Da
    Quaternary structure:
    • Interacts with RPA2.

neXtProt entry for SERTAD3 Gene

Proteomics data for SERTAD3 Gene at MOPED

Post-translational modifications for SERTAD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERTAD3 Gene

No data available for DME Specific Peptides for SERTAD3 Gene

Domains for SERTAD3 Gene

Protein Domains for SERTAD3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SRTD3_HUMAN
Domain:
  • Contains 1 SERTA domain.:
    • Q9UJW9
genes like me logo Genes that share domains with SERTAD3: view

No data available for Gene Families for SERTAD3 Gene

Function for SERTAD3 Gene

Molecular function for SERTAD3 Gene

UniProtKB/Swiss-Prot Function: Strong transcriptional coactivator.

Gene Ontology (GO) - Molecular Function for SERTAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10982866
genes like me logo Genes that share ontologies with SERTAD3: view

miRNA for SERTAD3 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SERTAD3 Gene

Localization for SERTAD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERTAD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERTAD3 Gene COMPARTMENTS Subcellular localization image for SERTAD3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SERTAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10982866
genes like me logo Genes that share ontologies with SERTAD3: view

Pathways for SERTAD3 Gene

SuperPathways for SERTAD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERTAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 10982866
GO:0030308 negative regulation of cell growth IDA 16098148
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SERTAD3: view

No data available for Pathways by source for SERTAD3 Gene

Transcripts for SERTAD3 Gene

Unigene Clusters for SERTAD3 Gene

SERTA domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5:

Relevant External Links for SERTAD3 Gene

GeneLoc Exon Structure for
SERTAD3
ECgene alternative splicing isoforms for
SERTAD3

Expression for SERTAD3 Gene

mRNA expression in normal human tissues for SERTAD3 Gene

SOURCE GeneReport for Unigene cluster for SERTAD3 Gene Hs.515412

genes like me logo Genes that share expressions with SERTAD3: view

Orthologs for SERTAD3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SERTAD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERTAD3 36
  • 99.83 (n)
  • 100 (a)
SERTAD3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERTAD3 36
  • 88.78 (n)
  • 92.86 (a)
SERTAD3 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERTAD3 36
  • 88.21 (n)
  • 91.28 (a)
SERTAD3 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sertad3 36
  • 83.76 (n)
  • 85.64 (a)
Sertad3 16
Sertad3 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sertad3 36
  • 84.1 (n)
  • 84.1 (a)
Species with no ortholog for SERTAD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERTAD3 Gene

ENSEMBL:
Gene Tree for SERTAD3 (if available)
TreeFam:
Gene Tree for SERTAD3 (if available)

Paralogs for SERTAD3 Gene

No data available for Paralogs for SERTAD3 Gene

Variants for SERTAD3 Gene

Sequence variations from dbSNP and Humsavar for SERTAD3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs174865 -- 40,444,526(-) CGGAG(G/T)CGCTG upstream-variant-2KB
rs183852 -- 40,444,402(-) CGCGG(C/T)GGGCG upstream-variant-2KB
rs268689 -- 40,445,439(-) ttaca(A/G)gcgtg upstream-variant-2KB
rs268690 -- 40,444,902(-) AGGAC(C/G)TGCTG upstream-variant-2KB
rs268691 -- 40,443,765(-) GAAGG(A/G)GGTTG upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERTAD3 Gene

Variant ID Type Subtype PubMed ID
nsv833831 CNV Loss 17160897
dgv3867n71 CNV Loss 21882294
nsv911709 CNV Loss 21882294
nsv819017 CNV Loss 19587683

Relevant External Links for SERTAD3 Gene

HapMap Linkage Disequilibrium report
SERTAD3

Disorders for SERTAD3 Gene

(1) University of Copenhagen DISEASES for SERTAD3 Gene

genes like me logo Genes that share disorders with SERTAD3: view

No data available for UniProtKB/Swiss-Prot for SERTAD3 Gene

Publications for SERTAD3 Gene

  1. RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A. (PMID: 10982866) Cho J.M. … Alaoui-Jamali M.A. (Nucleic Acids Res. 2000) 2 3 4 23
  2. TRIP-Br: a novel family of PHD zinc finger- and bromodomain- interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PMID: 11331592) Hsu S.-I. … Bonventre J.V. (EMBO J. 2001) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. SEI family of nuclear factors regulates p53-dependent transcriptional activation. (PMID: 16098148) Watanabe-Fukunaga R. … Fukunaga R. (Genes Cells 2005) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for SERTAD3 Gene

Sources for SERTAD3 Gene

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