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Aliases for SERTAD2 Gene

Aliases for SERTAD2 Gene

  • SERTA Domain Containing 2 2 3
  • Transcriptional Regulator Interacting With The PHS-Bromodomain 2 2 3
  • Transcriptional Regulator Interacting With The PHD-Bromodomain 2 3 4
  • TRIP-Br2 3 4
  • SERTA Domain-Containing Protein 2 3
  • KIAA0127 4
  • Sei-2 3

External Ids for SERTAD2 Gene

Previous GeneCards Identifiers for SERTAD2 Gene

  • GC02M064834
  • GC02M064770
  • GC02M064858

Summaries for SERTAD2 Gene

GeneCards Summary for SERTAD2 Gene

SERTAD2 (SERTA Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is CDCA4.

UniProtKB/Swiss-Prot for SERTAD2 Gene

  • Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERTAD2 Gene

Genomics for SERTAD2 Gene

Regulatory Elements for SERTAD2 Gene

Genomic Location for SERTAD2 Gene

Start:
64,631,621 bp from pter
End:
64,751,005 bp from pter
Size:
119,385 bases
Orientation:
Minus strand

Genomic View for SERTAD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERTAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTAD2 Gene

Proteins for SERTAD2 Gene

  • Protein details for SERTAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14140-SRTD2_HUMAN
    Recommended name:
    SERTA domain-containing protein 2
    Protein Accession:
    Q14140
    Secondary Accessions:
    • Q53TS2

    Protein attributes for SERTAD2 Gene

    Size:
    314 amino acids
    Molecular mass:
    33897 Da
    Quaternary structure:
    • Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes.
    SequenceCaution:
    • Sequence=BAA09476.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SERTAD2 Gene

Proteomics data for SERTAD2 Gene at MOPED

Post-translational modifications for SERTAD2 Gene

  • Polyubiquitinated, which promotes proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERTAD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERTAD2 Gene

Domains for SERTAD2 Gene

Protein Domains for SERTAD2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERTAD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14140

UniProtKB/Swiss-Prot:

SRTD2_HUMAN :
  • Q14140
Domain:
  • Contains 1 SERTA domain.
genes like me logo Genes that share domains with SERTAD2: view

No data available for Gene Families for SERTAD2 Gene

Function for SERTAD2 Gene

Molecular function for SERTAD2 Gene

UniProtKB/Swiss-Prot Function: Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.

Gene Ontology (GO) - Molecular Function for SERTAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SERTAD2: view
genes like me logo Genes that share phenotypes with SERTAD2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SERTAD2 Gene

Localization for SERTAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERTAD2 Gene

Nucleus. Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERTAD2 Gene COMPARTMENTS Subcellular localization image for SERTAD2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SERTAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16098148
GO:0005737 cytoplasm IDA 16098148
genes like me logo Genes that share ontologies with SERTAD2: view

Pathways for SERTAD2 Gene

SuperPathways for SERTAD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERTAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0030308 negative regulation of cell growth IDA 16098148
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SERTAD2: view

No data available for Pathways by source for SERTAD2 Gene

Transcripts for SERTAD2 Gene

Unigene Clusters for SERTAD2 Gene

SERTA domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD2 Gene

No ASD Table

Relevant External Links for SERTAD2 Gene

GeneLoc Exon Structure for
SERTAD2
ECgene alternative splicing isoforms for
SERTAD2

Expression for SERTAD2 Gene

mRNA expression in normal human tissues for SERTAD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for SERTAD2 Gene Hs.591569

mRNA Expression by UniProt/SwissProt for SERTAD2 Gene

Q14140-SRTD2_HUMAN
Tissue specificity: Expressed in adipose tissue.
genes like me logo Genes that share expressions with SERTAD2: view

No data available for mRNA differential expression in normal tissues and Protein expression for SERTAD2 Gene

Orthologs for SERTAD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERTAD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERTAD2 35
  • 99.58 (n)
  • 99.04 (a)
SERTAD2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERTAD2 35
  • 81 (n)
  • 82.41 (a)
SERTAD2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERTAD2 35
  • 81.79 (n)
  • 86.11 (a)
SERTAD2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sertad2 35
  • 87.4 (n)
  • 87.62 (a)
Sertad2 16
Sertad2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERTAD2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERTAD2 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sertad2 35
  • 87.15 (n)
  • 86.94 (a)
chicken
(Gallus gallus)
Aves SERTAD2 35
  • 80.24 (n)
  • 81.41 (a)
SERTAD2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERTAD2 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sertad2 35
  • 75.19 (n)
  • 77.99 (a)
Str.19163 35
zebrafish
(Danio rerio)
Actinopterygii sertad2b 35
  • 68.54 (n)
  • 67.55 (a)
sertad2b 36
  • 53 (a)
OneToOne
Species with no ortholog for SERTAD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERTAD2 Gene

ENSEMBL:
Gene Tree for SERTAD2 (if available)
TreeFam:
Gene Tree for SERTAD2 (if available)

Paralogs for SERTAD2 Gene

Paralogs for SERTAD2 Gene

genes like me logo Genes that share paralogs with SERTAD2: view

Variants for SERTAD2 Gene

Sequence variations from dbSNP and Humsavar for SERTAD2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7451 -- 64,632,545(-) GAAGG(A/G)GCAAC utr-variant-3-prime
rs847815 -- 64,752,743(-) CAGGA(C/T)TACTG upstream-variant-2KB
rs847816 -- 64,751,025(-) GCTCA(C/G)CTCTT upstream-variant-2KB
rs847817 -- 64,750,119(-) CTTCC(C/T)CCGCC intron-variant
rs871433 -- 64,713,466(-) tctat(A/G)aacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERTAD2 Gene

Variant ID Type Subtype PubMed ID
nsv7313 OTHER Inversion 18451855
nsv2756 CNV Loss 18451855
nsv820222 CNV Loss 19587683

Relevant External Links for SERTAD2 Gene

HapMap Linkage Disequilibrium report
SERTAD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERTAD2 Gene

Disorders for SERTAD2 Gene

Relevant External Links for SERTAD2

Genetic Association Database (GAD)
SERTAD2
Human Genome Epidemiology (HuGE) Navigator
SERTAD2
genes like me logo Genes that share disorders with SERTAD2: view

No data available for UniProtKB/Swiss-Prot for SERTAD2 Gene

Publications for SERTAD2 Gene

  1. CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. (PMID: 18316374) Cheong J.K. … Hsu S.I. (J. Biol. Chem. 2008) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  3. TRIP-Br: a novel family of PHD zinc finger- and bromodomain- interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PMID: 11331592) Hsu S.-I. … Bonventre J.V. (EMBO J. 2001) 2 3 4
  4. TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors. (PMID: 19152710) Cheong J.K. … Hsu S.I. (J Transl Med 2009) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SERTAD2 Gene

Sources for SERTAD2 Gene

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