SERTAD2 Gene

Aliases
for SERTAD2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC02M064834 GC02M064770 GC02M064592

Summaries
for SERTAD2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for SERTAD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000002.11  NT_022184.16  NC_018913.2  

SwitchGear Promoter luciferase reporter plasmid: SERTAD2 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERTAD2

SERTAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M064858:  view genomic region     (about GC identifiers)

Proteins
for SERTAD2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for SERTAD2: NX_Q14140

Explore proteomics data for SERTAD2 at MOPED

Post-translational modifications: 

SERTAD2 Human Recombinant Protein Products:

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	antibodies-online proteins for SERTAD2 (3 products)
	antibodies-online peptides for SERTAD2

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SERTAD2 Assay Products:

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Domains /
Families
for SERTAD2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q14140

Find genes that share domains with SERTAD2           About GenesLikeMe

Function
for SERTAD2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Sertad2)

genOway: Develop your customized and physiologically relevant rodent model for SERTAD2

miRNA Products:		miRTarBase miRNAs that target SERTAD2: hsa-mir-151a-5p (MIRT019527), hsa-mir-296-3p (MIRT038482), hsa-mir-98-5p (MIRT027470), hsa-mir-375 (MIRT019769), hsa-mir-210-3p (MIRT003157), hsa-mir-340-5p (MIRT019555), hsa-mir-155-5p (MIRT005095), hsa-mir-124-3p (MIRT022235), hsa-mir-7-5p (MIRT025710), hsa-mir-93-5p (MIRT027995), hsa-mir-183-5p (MIRT025013), hsa-mir-33a-5p (MIRT028231)
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		Selected qRT-PCR Assays for microRNAs that regulate SERTAD2 (see all 98):
		hsa-miR-3607-3p hsa-miR-607 hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-374a hsa-miR-3653 hsa-miR-502-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SERTAD2

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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERTAD2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERTAD2

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERTAD2

Localization
for SERTAD2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
cytosol	2

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for SERTAD2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for SERTAD2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for SERTAD2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for SERTAD2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SERTAD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Brain (Nervous System)    fully expand to see all 4 entries
Cerebral Cortex
Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast
Ovary (Reproductive System)
Oviduct
Testis (Reproductive System)
Leydig Cells Testis Interstitium
Liver (Hepatobiliary System)
Hepatocytes Liver Lobule

Primer Products:		OriGene qPCR primer pairs and template standards for SERTAD2 OriGene qSTAR qPCR primer pairs in human, mouse for SERTAD2
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERTAD2
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERTAD2

Orthologs
for SERTAD2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for SERTAD2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for SERTAD2 gene

CDCA4²  

Find genes that share paralogs with SERTAD2           About GenesLikeMe

Genomic Variants
for SERTAD2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SERTAD2 (see all 507)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1430918591,2	C	--	64616546(+)	CTTAAC/TGAGAC	1	--	us2k1		0	--	--	--	--
rs1163682461,2	F	--	64858259(+)	CAAGCG/ATGGAG	1	--	int1		1		WA	118
rs1809375601,2		--	64858278(+)	TGAAGA/GCAACG	1	--	int1		0	--	--	--	--
rs1413032111,2	C	--	64858632(+)	ACCAAC/TAGCAC	1	--	int1		0	--	--	--	--
rs1169911561,2	C,F	--	64858885(+)	GGTTCC/TGATGT	1	--	ut31		1		EA	120
rs1123923941,2	C	--	64858906(+)	ATATTC/G/TCATAG	2	--	ut31		1		CSA	1
rs1852113661,2		--	64859030(+)	TCGGTC/TATGCG	1	--	ut31		0	--	--	--	--
rs1910543241,2		--	64859035(+)	CATGCA/GCACAT	1	--	ut31		0	--	--	--	--
rs1449756281,2		--	64859042(+)	ACATAC/TGGCCT	1	--	ut31		0	--	--	--	--
rs1836669111,2		--	64859239(+)	GAAGGC/TAACCA	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for SERTAD2 (64858755 - 64978139 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for SERTAD2:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv820222	CNV	Loss	19587683
nsv2756	CNV	Loss	18451855
nsv7313	OTHER	Inversion	18451855

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing SERTAD2

DNA2.0 Custom Variant and Variant Library Synthesis for SERTAD2

Disorders / Diseases
for SERTAD2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for SERTAD2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. TRIP-Br: a novel family of PHD zinc finger- and bromodomain- interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PubMed id 11331592)^{1, 2, 3} Hsu S.-I....Bonventre J.V. (EMBO J. 2001)
2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)^{1, 2, 3} Nagase T.... Nomura N. (DNA Res. 1995)
3. CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. (PubMed id 18316374)^{1, 2, 9} Cheong J.K....Hsu S.I. (J. Biol. Chem. 2008)
4. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. (PubMed id 23291629)^{1, 2} Liew C.W....Kulkarni R.N. (Nat. Med. 2013)
5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W.... Wilson R.K. (Nature 2005)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
8. TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors. (PubMed id 19152710)^{1, 9} Cheong J.K....Hsu S.I. (J Transl Med 2009)
9. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)¹ Fox C.S....Borecki I.B. (PLoS Genet. 2012)
10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)

External Searches for SERTAD2 gene

Genome Databases showing SERTAD2 gene

Other Databases showing SERTAD2 gene

Specialized Databases showing SERTAD2 gene

Products
for SERTAD2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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