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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERTAD2 Gene

protein-coding   GIFtS: 47
GCID: GC02M064770

SERTA Domain Containing 2

  Search for SERTAD2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SERTA Domain Containing 21 2     Sei-22
Transcriptional Regulator Interacting With The PHS-Bromodomain 21 2     SERTA Domain-Containing Protein 22
Transcriptional Regulator Interacting With The PHD-Bromodomain 22 3     KIAA01273
TRIP-Br22 3     

External Ids:    HGNC: 307841   Entrez Gene: 97922   Ensembl: ENSG000001798337   UniProtKB: Q141403   

Export aliases for SERTAD2 gene to outside databases

Previous GC identifers: GC02M064834 GC02M064592


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SERTAD2 Gene: 
SERTAD2 (SERTA domain containing 2) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is CDCA4.

UniProtKB/Swiss-Prot: SRTD2_HUMAN, Q14140
Function: Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing
transcription factors (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERTAD2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Olf-1   POU6F1 (c2)   Nkx3-1 v1   GATA-1   Evi-1   Nkx3-1 v2   GATA-6   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERTAD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERTAD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERTAD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p14   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p15

SERTAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERTAD2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M064770:  view genomic region     (about GC identifiers)

Start:
64,858,755 bp from pter      End:
64,977,449 bp from pter
Size:
118,695 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRTD2_HUMAN, Q14140 (See protein sequence)
Recommended Name: SERTA domain-containing protein 2  
Size: 314 amino acids; 33897 Da
Sequence caution: Sequence=BAA09476.2; Type=Erroneous initiation;
Secondary accessions: Q53TS2

Explore the universe of human proteins at neXtProt for SERTAD2: NX_Q14140

Explore proteomics data for SERTAD2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14140

  • SERTAD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERTAD2 Protein Expression
    REFSEQ proteins: NP_055570.1  
    ENSEMBL proteins: 
     ENSP00000326933  

    Human Recombinant Protein Products for SERTAD2: 
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    Cloud-Clone Corp. Proteins for SERTAD2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16098148
    GO:0005737cytoplasm IDA16098148

    SERTAD2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009263 SERTA

    Graphical View of Domain Structure for InterPro Entry Q14140

    ProtoNet protein and cluster: Q14140

    1 Blocks protein domain: IPB009263 SERTA

    UniProtKB/Swiss-Prot: SRTD2_HUMAN, Q14140
    Similarity: Contains 1 SERTA domain


    SERTAD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRTD2_HUMAN, Q14140
    Function: Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing
    transcription factors (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IEA--
    GO:0005515protein binding ----
         
    SERTAD2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SERTAD2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sertad2):
     adipose tissue  cellular  growth/size  homeostasis/metabolism  immune system 
     integument  liver/biliary system 

    SERTAD2 for phenotypes           About GeneDecksing

    Animal Models:
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    miRTarBase miRNAs that target SERTAD2:
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    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate SERTAD2 (see all 98):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-374a hsa-miR-3653 hsa-miR-502-3p
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERTAD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for SERTAD2 (Q141403 ENSP000003269334) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM28Q132633, ENSP000002530244I2D: score=3 STRING: ENSP00000253024
    E2F1Q010943, ENSP000003455714I2D: score=2 STRING: ENSP00000345571
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    TFDP1Q141863, ENSP000003645194I2D: score=2 STRING: ENSP00000364519
    KAT2BQ928313, ENSP000002637544I2D: score=1 STRING: ENSP00000263754
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0030308negative regulation of cell growth IDA16098148
    GO:0045893positive regulation of transcription, DNA-dependent IEA--

    SERTAD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERTAD2 (SRTD2)

    Search CenterWatch for drugs/clinical trials and news about SERTAD2 / SRTD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERTAD2 gene: 
    NM_014755.2  

    Unigene Cluster for SERTAD2:

    SERTA domain containing 2
    Hs.591569  [show with all ESTs]
    Unigene Representative Sequence: NM_014755
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313349(uc002sde.2) ENST00000476805
    miRNA
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    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate SERTAD2 (see all 98):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-374a hsa-miR-3653 hsa-miR-502-3p
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERTAD2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERTAD2

    Additional mRNA sequence: 

    AK311117.1 BC074788.2 BC074789.2 BC101639.1 BC101641.1 D50917.1 

    8 DOTS entries:

    DT.418700  DT.99982477  DT.87014249  DT.91754772  DT.100060546  DT.100681863  DT.75149815  DT.95366098 

    24/206 AceView cDNA sequences (see all 206):

    BQ014466 W58085 H89759 AI032472 AI075890 AA283647 AI589236 AU134908 
    AA644291 AI335745 BU150508 BG149922 BP341123 BF061406 BC074789 AI538863 
    AA902590 H89683 AA810121 BE328016 BC074788 W58099 W03762 AI276657 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERTAD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SERTAD2 Expression
    About this image


    See SERTAD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERTAD2

    SOURCE GeneReport for Unigene cluster: Hs.591569
        SABiosciences Custom PCR Arrays for SERTAD2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SERTAD2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sertad21 , 5 SERTA domain containing 21, 5 87.84(n)1
    88.27(a)1
      11 (13.03 cM)5
    581721  NM_001038625.11  NP_001033714.11 
     205432535 
    chicken
    (Gallus gallus)
    Aves SERTAD21 SERTA domain containing 2 80.24(n)
    81.41(a)
      421276  NM_001031037.1  NP_001026208.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERTAD26
    --
    Uncharacterized protein
    80(a)
    29(a)
    1 ↔ 1
    possible ortholog
    1(124150447-124151406)
    1(3610480-3611334)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ087056.12   -- 87.72(n)    BJ087056.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sertad2b1 SERTA domain containing 2b 68.51(n)
    67.1(a)
      368888  NM_212794.1  NP_997959.1 


    ENSEMBL Gene Tree for SERTAD2 (if available)
    TreeFam Gene Tree for SERTAD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERTAD2 gene
    CDCA42  

    SERTAD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/507 SNPs in SERTAD2 are shown (see all 507)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1430918591,2
    C--64616546(+) CTTAAC/TGAGAC 1 -- us2k10--------
    rs1163682461,2
    F--64858259(+) CAAGCG/ATGGAG 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1809375601,2
    --64858278(+) TGAAGA/GCAACG 1 -- int10--------
    rs1413032111,2
    C--64858632(+) ACCAAC/TAGCAC 1 -- int10--------
    rs1169911561,2
    C,F--64858885(+) GGTTCC/TGATGT 1 -- ut311Minor allele frequency- T:0.03EA 120
    rs1123923941,2
    C--64858906(+) ATATTC/G/TCATAG 2 -- ut311CSA 1
    rs1852113661,2
    --64859030(+) TCGGTC/TATGCG 1 -- ut310--------
    rs1910543241,2
    --64859035(+) CATGCA/GCACAT 1 -- ut310--------
    rs1449756281,2
    --64859042(+) ACATAC/TGGCCT 1 -- ut310--------
    rs1836669111,2
    --64859239(+) GAAGGC/TAACCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SERTAD2 (64858755 - 64977449 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SERTAD2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv820222CNV Loss19587683
    nsv2756CNV Loss18451855
    nsv7313OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SERTAD2 for disorders           About MalaCards

    SERTAD2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SERTAD2
    Human Genome Epidemiology (HuGE) Navigator: SERTAD2 (1 document)

    Export disorders for SERTAD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERTAD2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with SERTAD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T....Nomura N. (1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. TRIP-Br: a novel family of PHD zinc finger- and bromodomain- interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PubMed id 11331592)1, 3 Hsu S.-I....Bonventre J.V. (2001)
    6. TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors. (PubMed id 19152710)1, 9 Cheong J.K....Hsu S.I. (2009)
    7. CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. (PubMed id 18316374)1, 9 Cheong J.K....Hsu S.I. (2008)
    8. Ablation of TRIP-Br2, a regulator of fat lipolysis, th ermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. (PubMed id 23291629)1 Liew C.W....Kulkarni R.N. (2013)
    9. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9792 HGNC: 30784 AceView: SERTAD2 Ensembl:ENSG00000179833 euGenes: HUgn9792
    ECgene: SERTAD2 H-InvDB: SERTAD2

    (According to HUGE)
    About This Section
    HUGE: KIAA0127

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERTAD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERTAD2 gene:
    Search GeneIP for patents involving SERTAD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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