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SERTAD2 Gene

protein-coding   GIFtS: 48
GCID: GC02M064858

SERTA Domain Containing 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SERTA Domain Containing 21 2     Sei-22
Transcriptional Regulator Interacting With The PHS-Bromodomain 21 2     SERTA Domain-Containing Protein 22
Transcriptional Regulator Interacting With The PHD-Bromodomain 22 3     KIAA01273
TRIP-Br22 3     

External Ids:    HGNC: 307841   Entrez Gene: 97922   Ensembl: ENSG000001798337   UniProtKB: Q141403   

Export aliases for SERTAD2 gene to outside databases

Previous GC identifers: GC02M064834 GC02M064770 GC02M064592


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERTAD2 Gene:
SERTAD2 (SERTA domain containing 2) is a protein-coding gene. Diseases associated with SERTAD2 include insulin resistance, and obesity. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is CDCA4.

UniProtKB/Swiss-Prot: SRTD2_HUMAN, Q14140
Function: Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or
bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and
E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression.
Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis,
thermogenesis and oxidative metabolism




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERTAD2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Olf-1   POU6F1 (c2)   Nkx3-1 v1   GATA-1   Evi-1   Nkx3-1 v2   GATA-6   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERTAD2 promoter sequence
   Search Chromatin IP Primers for SERTAD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERTAD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p14   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p15

SERTAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERTAD2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M064858:  view genomic region     (about GC identifiers)

Start:
64,858,755 bp from pter      End:
64,978,139 bp from pter
Size:
119,385 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRTD2_HUMAN, Q14140 (See protein sequence)
Recommended Name: SERTA domain-containing protein 2  
Size: 314 amino acids; 33897 Da
Subunit: Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation
activity of TFDP1/E2F complexes
Developmental stage: Transcript levels remain constant in all phases of the cell cycle. In contrast, protein
levels accumulate at the G1/S phase boundary and decrease progressively through S phase until G2/M phase is
reached, residual expression is observed in the G2/M and early G1 phases
Sequence caution: Sequence=BAA09476.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q53TS2

Explore the universe of human proteins at neXtProt for SERTAD2: NX_Q14140

Explore proteomics data for SERTAD2 at MOPED

Post-translational modifications: 

  • Polyubiquitinated, which promotes proteasomal degradation1
  • Modification sites at neXtProt

  • See SERTAD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055570.1  
    ENSEMBL proteins: 
     ENSP00000326933  

    SERTAD2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SERTAD2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009263 SERTA

    Graphical View of Domain Structure for InterPro Entry Q14140

    ProtoNet protein and cluster: Q14140

    1 Blocks protein domain: IPB009263 SERTA

    UniProtKB/Swiss-Prot: SRTD2_HUMAN, Q14140
    Similarity: Contains 1 SERTA domain


    SERTAD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRTD2_HUMAN, Q14140
    Function: Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or
    bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and
    E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression.
    Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis,
    thermogenesis and oxidative metabolism

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IEA--
    GO:0005515protein binding ----
         
    SERTAD2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SERTAD2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sertad2):
     adipose tissue  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system 

    SERTAD2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERTAD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SERTAD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERTAD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERTAD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SERTAD2:
    hsa-mir-151a-5p (MIRT019527), hsa-mir-296-3p (MIRT038482), hsa-mir-98-5p (MIRT027470), hsa-mir-375 (MIRT019769), hsa-mir-210-3p (MIRT003157), hsa-mir-340-5p (MIRT019555), hsa-mir-155-5p (MIRT005095), hsa-mir-124-3p (MIRT022235), hsa-mir-7-5p (MIRT025710), hsa-mir-93-5p (MIRT027995), hsa-mir-183-5p (MIRT025013), hsa-mir-33a-5p (MIRT028231)

    Block miRNA regulation of human, mouse, rat SERTAD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERTAD2 (see all 98):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-374a hsa-miR-3653 hsa-miR-502-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat SERTAD2

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    GenScript: all cDNA clones in your preferred vector: SERTAD2 (NM_014755)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERTAD2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERTAD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRTD2_HUMAN, Q14140: Nucleus. Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner.
    Once in the cytoplasm, is degraded by the proteasome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16098148
    GO:0005737cytoplasm IDA16098148

    SERTAD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERTAD2
    Interactions:

        GeneGlobe Interaction Network for SERTAD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for SERTAD2 (Q141403 ENSP000003269334) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM28Q132633, ENSP000002530244I2D: score=3 STRING: ENSP00000253024
    E2F1Q010943, ENSP000003455714I2D: score=2 STRING: ENSP00000345571
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    TFDP1Q141863, ENSP000003645194I2D: score=2 STRING: ENSP00000364519
    KAT2BQ928313, ENSP000002637544I2D: score=1 STRING: ENSP00000263754
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0030308negative regulation of cell growth IDA16098148
    GO:0045893positive regulation of transcription, DNA-templated IEA--

    SERTAD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERTAD2 (SRTD2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SERTAD2 gene: 
    NM_014755.2  

    Unigene Cluster for SERTAD2:

    SERTA domain containing 2
    Hs.591569  [show with all ESTs]
    Unigene Representative Sequence: NM_014755
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313349(uc002sde.2) ENST00000476805 ENST00000608423
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SERTAD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERTAD2 (see all 98):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-374a hsa-miR-3653 hsa-miR-502-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SERTAD2
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    GenScript: all cDNA clones in your preferred vector: SERTAD2 (NM_014755)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERTAD2
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    OriGene qPCR primer pairs and template standards for SERTAD2
    OriGene qSTAR qPCR primer pairs in human, mouse for SERTAD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERTAD2
      QuantiTect SYBR Green Assays in human, mouse, rat SERTAD2
      QuantiFast Probe-based Assays in human, mouse, rat SERTAD2

    Additional mRNA sequence: 

    AK311117.1 BC074788.2 BC074789.2 BC101639.1 BC101641.1 D50917.1 

    8 DOTS entries:

    DT.418700  DT.99982477  DT.87014249  DT.91754772  DT.100060546  DT.100681863  DT.75149815  DT.95366098 

    Selected AceView cDNA sequences (see all 206):

    AA810121 AA902590 AI675041 BQ014466 AI335745 BU150508 AA126268 AA126386 
    AA644291 BP341123 AA312838 BC074789 BG149922 AI589236 AI538863 BF061406 
    W58099 AI032472 H89683 AA283647 AI075890 W58085 BQ215809 D50917 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERTAD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SERTAD2 Expression
    About this image


    SERTAD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    SERTAD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERTAD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591569

    UniProtKB/Swiss-Prot: SRTD2_HUMAN, Q14140
    Tissue specificity: Expressed in adipose tissue

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SERTAD2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sertad21 , 5 SERTA domain containing 21, 5 87.4(n)1
    87.62(a)1
      11 (13.03 cM)5
    581721  NM_021372.21  NP_067347.21 
     205432535 
    chicken
    (Gallus gallus)
    Aves SERTAD21 SERTA domain containing 2 80.24(n)
    81.41(a)
      421276  NM_001031037.1  NP_001026208.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERTAD26
    SERTA domain containing 2
    80(a)
    1 ↔ 1
    1(124150447-124151406)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ087056.12   -- 87.72(n)    BJ087056.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sertad2b1 SERTA domain containing 2b 68.54(n)
    67.55(a)
      368888  NM_212794.1  NP_997959.1 


    ENSEMBL Gene Tree for SERTAD2 (if available)
    TreeFam Gene Tree for SERTAD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERTAD2 gene
    CDCA42  

    SERTAD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERTAD2 (see all 507)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1430918591,2
    C--64616546(+) CTTAAC/TGAGAC 1 -- us2k10--------
    rs1163682461,2
    F--64858259(+) CAAGCG/ATGGAG 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1809375601,2
    --64858278(+) TGAAGA/GCAACG 1 -- int10--------
    rs1413032111,2
    C--64858632(+) ACCAAC/TAGCAC 1 -- int10--------
    rs1169911561,2
    C,F--64858885(+) GGTTCC/TGATGT 1 -- ut311Minor allele frequency- T:0.03EA 120
    rs1123923941,2
    C--64858906(+) ATATTC/G/TCATAG 2 -- ut311CSA 1
    rs1852113661,2
    --64859030(+) TCGGTC/TATGCG 1 -- ut310--------
    rs1910543241,2
    --64859035(+) CATGCA/GCACAT 1 -- ut310--------
    rs1449756281,2
    --64859042(+) ACATAC/TGGCCT 1 -- ut310--------
    rs1836669111,2
    --64859239(+) GAAGGC/TAACCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SERTAD2 (64858755 - 64978139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SERTAD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820222CNV Loss19587683
    nsv2756CNV Loss18451855
    nsv7313OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SERTAD2
    DNA2.0 Custom Variant and Variant Library Synthesis for SERTAD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for SERTAD2:    
    About MalaCards
    insulin resistance    obesity


    SERTAD2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SERTAD2
    Human Genome Epidemiology (HuGE) Navigator: SERTAD2 (1 document)

    Export disorders for SERTAD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERTAD2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with SERTAD2)
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    1. TRIP-Br: a novel family of PHD zinc finger- and bromodomain- interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PubMed id 11331592)1, 2, 3 Hsu S.-I....Bonventre J.V. (EMBO J. 2001)
    2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
    3. CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. (PubMed id 18316374)1, 2, 9 Cheong J.K....Hsu S.I. (J. Biol. Chem. 2008)
    4. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. (PubMed id 23291629)1, 2 Liew C.W....Kulkarni R.N. (Nat. Med. 2013)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors. (PubMed id 19152710)1, 9 Cheong J.K....Hsu S.I. (J Transl Med 2009)
    9. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9792 HGNC: 30784 AceView: SERTAD2 Ensembl:ENSG00000179833 euGenes: HUgn9792
    ECgene: SERTAD2 H-InvDB: SERTAD2

    (According to HUGE)
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    HUGE: KIAA0127

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERTAD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERTAD2 gene:
    Search GeneIP for patents involving SERTAD2

    GeneCards and IP:
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