Aliases for SERTAD2 Gene
Aliases for SERTAD2 Gene
External Ids for SERTAD2 Gene
- HGNC: 30784
- Entrez Gene: 9792
- Ensembl: ENSG00000179833
- UniProtKB: Q14140
Previous GeneCards Identifiers for SERTAD2 Gene
- GC02M064834
- GC02M064770
- GC02M064858
Summaries for SERTAD2 Gene
GeneCards Summary for SERTAD2 Gene
SERTAD2 (SERTA Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is CDCA4.
UniProtKB/Swiss-Prot for SERTAD2 Gene
-
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERTAD2 Gene
Genomics for SERTAD2 Gene
Regulatory Elements for SERTAD2 Gene
Enhancers for SERTAD2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around SERTAD2 on UCSC Golden Path with GeneCards custom track
Promoters for SERTAD2 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around SERTAD2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SERTAD2 gene promoter:
Regulatory Element Products
Genomic Location for SERTAD2 Gene
- Chromosome:
- 2
- Start:
- 64,631,621 bp from pter
- End:
- 64,751,091 bp from pter
- Size:
- 119,471 bases
- Orientation:
- Minus strand
Genomic View for SERTAD2 Gene
Genes around SERTAD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p14 by Ensembl
- 2p14 by Entrez Gene
- 2p15 by HGNC
SERTAD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SERTAD2 Gene
Proteins for SERTAD2 Gene
-
Protein details for SERTAD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14140-SRTD2_HUMAN
- Recommended name:
- SERTA domain-containing protein 2
- Protein Accession:
- Q14140
- Q53TS2
Protein attributes for SERTAD2 Gene
- Size:
- 314 amino acids
- Molecular mass:
- 33897 Da
- Quaternary structure:
-
- Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes.
- SequenceCaution:
-
- Sequence=BAA09476.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Post-translational modifications for SERTAD2 Gene
- Polyubiquitinated, which promotes proteasomal degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SERTAD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SERTAD2
- Invitrogen Antibodies for SERTAD2
- antibodies-online Antibodies for SERTAD2: See all 42
- GeneTex SERTAD2 antibody for SERTAD2
-
Santa Cruz Biotechnology (SCBT) Antibodies for SERTAD2
Protein Products
-
OriGene Purified Proteins for SERTAD2
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- antibodies-online Proteins for SERTAD2: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SERTAD2
Assay Products
No data available for DME Specific Peptides for SERTAD2 Gene
Domains & Families for SERTAD2 Gene
Suggested Antigen Peptide Sequences for SERTAD2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14140- Domain:
-
- Contains 1 SERTA domain.
No data available for Gene Families for SERTAD2 Gene
Function for SERTAD2 Gene
Molecular function for SERTAD2 Gene
- UniProtKB/Swiss-Prot Function:
- Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.
Phenotypes for SERTAD2 Gene
- MGI mutant phenotypes for SERTAD2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SERTAD2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for SERTAD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SERTAD2 gene
- Search ViGene Biosciences for SERTAD2
CRISPR Products
-
OriGene CRISPR knockouts for SERTAD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERTAD2
- GenScript: Design CRISPR guide RNA sequences for SERTAD2
miRNA for SERTAD2 Gene
- miRTarBase miRNAs that target SERTAD2
-
- hsa-mir-210-3p (MIRT003157)
- hsa-mir-155-5p (MIRT005095)
- hsa-mir-151a-5p (MIRT019527)
- hsa-mir-340-5p (MIRT019555)
- hsa-mir-375 (MIRT019769)
- hsa-mir-124-3p (MIRT022235)
- hsa-mir-183-5p (MIRT025013)
- hsa-mir-7-5p (MIRT025710)
- hsa-mir-98-5p (MIRT027470)
- hsa-mir-93-5p (MIRT027995)
- hsa-mir-33a-5p (MIRT028231)
- hsa-mir-296-3p (MIRT038482)
- hsa-mir-6875-3p (MIRT089205)
- hsa-mir-324-5p (MIRT206988)
- hsa-mir-1277-5p (MIRT243203)
- hsa-mir-5011-5p (MIRT243207)
- hsa-mir-190a-3p (MIRT329165)
- hsa-mir-4778-3p (MIRT389212)
- hsa-mir-205-5p (MIRT439675)
- hsa-mir-6781-5p (MIRT468523)
- hsa-mir-4532 (MIRT468524)
- hsa-mir-6850-3p (MIRT468525)
- hsa-mir-1247-3p (MIRT468526)
- hsa-mir-4659b-3p (MIRT546529)
- hsa-mir-4659a-3p (MIRT546530)
- hsa-mir-4799-5p (MIRT546531)
- hsa-mir-4662a-3p (MIRT546532)
- hsa-mir-5692a (MIRT546533)
- hsa-mir-4531 (MIRT565753)
- hsa-mir-3911 (MIRT565754)
- hsa-mir-7847-3p (MIRT565755)
- hsa-mir-5703 (MIRT565756)
- hsa-mir-4516 (MIRT565757)
- hsa-mir-4434 (MIRT565758)
- hsa-mir-7153-5p (MIRT565759)
- hsa-mir-146b-5p (MIRT565760)
- hsa-mir-146a-5p (MIRT565761)
- hsa-mir-4302 (MIRT565762)
- hsa-mir-216a-3p (MIRT565763)
- hsa-mir-128-3p (MIRT565764)
- hsa-mir-3681-3p (MIRT565765)
- hsa-mir-92b-3p (MIRT726624)
- hsa-mir-32-5p (MIRT726625)
- hsa-mir-92a-3p (MIRT726626)
miRNA Products
- Search ViGene Biosciences for SERTAD2
Clone Products
- OriGene clones in human for SERTAD2
- OriGene ORF clones in human,mouse,rat for SERTAD2
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SERTAD2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SERTAD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SERTAD2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERTAD2 Gene
Localization for SERTAD2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SERTAD2 Gene
- Nucleus. Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
No data available for Gene Ontology (GO) - Cellular Components for SERTAD2 Gene
Pathways & Interactions for SERTAD2 Gene
More details on SuperPathways for SERTAD2
No Data Available
Interacting Proteins for SERTAD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030308 | negative regulation of cell growth | IDA | 16098148 |
| GO:0045893 | positive regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SERTAD2 Gene
Transcripts for SERTAD2 Gene
mRNA/cDNA for SERTAD2 Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (206) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SERTAD2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SERTAD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERTAD2
- GenScript: Design CRISPR guide RNA sequences for SERTAD2
miRNA Products
- Search ViGene Biosciences for SERTAD2
Clone Products
- OriGene clones in human for SERTAD2
- OriGene ORF clones in human,mouse,rat for SERTAD2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for SERTAD2 Gene
SOURCE GeneReport for Unigene cluster for SERTAD2 Gene Hs.591569
mRNA Expression by UniProt/SwissProt for SERTAD2 Gene
Q14140-SRTD2_HUMAN
Tissue specificity:
Expressed in adipose tissue.
Primer Products
-
OriGene qPCR primer pairs and template standards for SERTAD2
-
OriGene qPCR primer pairs for SERTAD2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SERTAD2 Gene
Orthologs for SERTAD2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | SERTAD2 35 |
|
||
| SERTAD2 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | SERTAD2 35 |
|
||
| SERTAD2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Sertad2 35 |
|
||
| Sertad2 16 |
|
||||
| Sertad2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | SERTAD2 35 |
|
||
| SERTAD2 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Sertad2 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SERTAD2 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SERTAD2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SERTAD2 35 |
|
||
| SERTAD2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | SERTAD2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sertad2 35 |
|
||
| Str.19163 35 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | sertad2b 35 |
|
||
| sertad2b 36 |
|
OneToOne |
- Species with no ortholog for SERTAD2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SERTAD2 Gene
Variants for SERTAD2 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1558703 | -- | 64,711,155(-) | GTGTG(A/T)CCCAG | intron-variant | |
| rs847815 | -- | 64,752,743(-) | CAGGA(C/T)TACTG | upstream-variant-2KB | |
| rs847816 | -- | 64,751,025(-) | GCTCA(C/G)CTCTT | utr-variant-5-prime | |
| rs847817 | -- | 64,750,119(-) | CTTCC(C/T)CCGCC | intron-variant | |
| rs1803493 | -- | 64,631,662(-) | TCTTA(A/C)TTTTG | utr-variant-3-prime |
Residual Variation Intolerance Score:
24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.76;
16.11% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SERTAD2 Gene
Disorders for SERTAD2 Gene
Relevant External Links for SERTAD2
No disorders were found for SERTAD2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERTAD2 Gene
Publications for SERTAD2 Gene
- TRIP-Br: a novel family of PHD zinc finger- and bromodomain- interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PMID: 11331592) Hsu S.-I. … Bonventre J.V. (EMBO J. 2001) 2 3 4 67
- TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors. (PMID: 19152710) Cheong J.K. … Hsu S.I. (J Transl Med 2009) 3 23
- CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. (PMID: 18316374) Cheong J.K. … Hsu S.I. (J. Biol. Chem. 2008) 3 23
- Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3
- Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. (PMID: 23291629) Liew C.W. … Kulkarni R.N. (Nat. Med. 2013) 3
Products for SERTAD2 Gene
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- OriGene Purified Proteins for SERTAD2
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- OriGene qPCR primer pairs for SERTAD2
- OriGene qPCR primer pairs and template standards for SERTAD2
- OriGene CRISPR knockouts for SERTAD2
- OriGene clones in human for SERTAD2
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- Novus Biologicals Antibodies for SERTAD2
- Novus Biologicals proteins and lysates for SERTAD2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for SERTAD2: See all 42
- Search antibodies-online for kits
- antibodies-online Proteins for SERTAD2: See all 5
- Search antibodies-online for peptides
- GeneTex SERTAD2 antibody for SERTAD2
- Search GeneTex for Proteins for SERTAD2
- ViGene Biosciences adenoviral particle packaged cDNA for SERTAD2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SERTAD2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SERTAD2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SERTAD2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SERTAD2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SERTAD2 gene
- Search ViGene Biosciences for SERTAD2
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- Santa Cruz Biotechnology (SCBT) Antibodies for SERTAD2
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- Santa Cruz Biotechnology (SCBT) CRISPR for SERTAD2
Sources for SERTAD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
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- (130) diseasecard
- (131) NIH Rare Diseases
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- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon