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Aliases for SERTAD2 Gene

Aliases for SERTAD2 Gene

  • SERTA Domain Containing 2 2 3 5
  • Transcriptional Regulator Interacting With The PHS-Bromodomain 2 2 3
  • Transcriptional Regulator Interacting With The PHD-Bromodomain 2 3 4
  • TRIP-Br2 3 4
  • KIAA0127 4
  • Sei-2 3

External Ids for SERTAD2 Gene

Previous GeneCards Identifiers for SERTAD2 Gene

  • GC02M064834
  • GC02M064770
  • GC02M064858

Summaries for SERTAD2 Gene

GeneCards Summary for SERTAD2 Gene

SERTAD2 (SERTA Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is CDCA4.

UniProtKB/Swiss-Prot for SERTAD2 Gene

  • Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERTAD2 Gene

Genomics for SERTAD2 Gene

Regulatory Elements for SERTAD2 Gene

Promoters for SERTAD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SERTAD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERTAD2 Gene

Chromosome:
2
Start:
64,631,621 bp from pter
End:
64,751,091 bp from pter
Size:
119,471 bases
Orientation:
Minus strand

Genomic View for SERTAD2 Gene

Genes around SERTAD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERTAD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERTAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTAD2 Gene

Proteins for SERTAD2 Gene

  • Protein details for SERTAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14140-SRTD2_HUMAN
    Recommended name:
    SERTA domain-containing protein 2
    Protein Accession:
    Q14140
    Secondary Accessions:
    • Q53TS2

    Protein attributes for SERTAD2 Gene

    Size:
    314 amino acids
    Molecular mass:
    33897 Da
    Quaternary structure:
    • Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes.
    SequenceCaution:
    • Sequence=BAA09476.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SERTAD2 Gene

Proteomics data for SERTAD2 Gene at MOPED

Post-translational modifications for SERTAD2 Gene

  • Polyubiquitinated, which promotes proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERTAD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERTAD2 Gene

Domains & Families for SERTAD2 Gene

Protein Domains for SERTAD2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERTAD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14140

UniProtKB/Swiss-Prot:

SRTD2_HUMAN :
  • Contains 1 SERTA domain.
Domain:
  • Contains 1 SERTA domain.
genes like me logo Genes that share domains with SERTAD2: view

No data available for Gene Families for SERTAD2 Gene

Function for SERTAD2 Gene

Molecular function for SERTAD2 Gene

UniProtKB/Swiss-Prot Function:
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.
genes like me logo Genes that share phenotypes with SERTAD2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERTAD2 Gene

Localization for SERTAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERTAD2 Gene

Nucleus. Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERTAD2 Gene COMPARTMENTS Subcellular localization image for SERTAD2 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for SERTAD2 Gene

Pathways & Interactions for SERTAD2 Gene

SuperPathways for SERTAD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERTAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth IDA 16098148
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SERTAD2: view

No data available for Pathways by source and SIGNOR curated interactions for SERTAD2 Gene

Drugs & Compounds for SERTAD2 Gene

No Compound Related Data Available

Transcripts for SERTAD2 Gene

Unigene Clusters for SERTAD2 Gene

SERTA domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD2 Gene

No ASD Table

Relevant External Links for SERTAD2 Gene

GeneLoc Exon Structure for
SERTAD2
ECgene alternative splicing isoforms for
SERTAD2

Expression for SERTAD2 Gene

mRNA expression in normal human tissues for SERTAD2 Gene

SOURCE GeneReport for Unigene cluster for SERTAD2 Gene Hs.591569

mRNA Expression by UniProt/SwissProt for SERTAD2 Gene

Q14140-SRTD2_HUMAN
Tissue specificity: Expressed in adipose tissue.
genes like me logo Genes that share expression patterns with SERTAD2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SERTAD2 Gene

Orthologs for SERTAD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERTAD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERTAD2 35
  • 99.58 (n)
  • 99.04 (a)
SERTAD2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERTAD2 36
  • 81 (a)
OneToOne
SERTAD2 35
  • 81 (n)
  • 82.41 (a)
dog
(Canis familiaris)
Mammalia SERTAD2 35
  • 81.79 (n)
  • 86.11 (a)
SERTAD2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sertad2 16
Sertad2 36
  • 87 (a)
OneToOne
Sertad2 35
  • 87.4 (n)
  • 87.62 (a)
oppossum
(Monodelphis domestica)
Mammalia SERTAD2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERTAD2 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sertad2 35
  • 87.15 (n)
  • 86.94 (a)
chicken
(Gallus gallus)
Aves SERTAD2 35
  • 80.24 (n)
  • 81.41 (a)
SERTAD2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERTAD2 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sertad2 35
  • 75.19 (n)
  • 77.99 (a)
Str.19163 35
zebrafish
(Danio rerio)
Actinopterygii sertad2b 36
  • 53 (a)
OneToOne
sertad2b 35
  • 68.54 (n)
  • 67.55 (a)
Species with no ortholog for SERTAD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERTAD2 Gene

ENSEMBL:
Gene Tree for SERTAD2 (if available)
TreeFam:
Gene Tree for SERTAD2 (if available)

Paralogs for SERTAD2 Gene

Paralogs for SERTAD2 Gene

genes like me logo Genes that share paralogs with SERTAD2: view

Variants for SERTAD2 Gene

Sequence variations from dbSNP and Humsavar for SERTAD2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs847817 -- 64,750,119(-) CTTCC(C/T)CCGCC intron-variant
rs954680 -- 64,685,911(+) TTGGG(C/G)AGAGA intron-variant
rs954681 -- 64,686,057(+) GATTT(C/G)AGCTG intron-variant
rs871433 -- 64,713,466(-) tctat(A/G)aacag intron-variant
rs997539 -- 64,743,997(+) CATTC(C/T)GGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERTAD2 Gene

Variant ID Type Subtype PubMed ID
nsv7313 OTHER Inversion 18451855
nsv2756 CNV Loss 18451855
nsv820222 CNV Loss 19587683

Variation tolerance for SERTAD2 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERTAD2 Gene

HapMap Linkage Disequilibrium report
SERTAD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERTAD2 Gene

Disorders for SERTAD2 Gene

Relevant External Links for SERTAD2

Genetic Association Database (GAD)
SERTAD2
Human Genome Epidemiology (HuGE) Navigator
SERTAD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERTAD2

No disorders were found for SERTAD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERTAD2 Gene

Publications for SERTAD2 Gene

  1. TRIP-Br: a novel family of PHD zinc finger- and bromodomain- interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PMID: 11331592) Hsu S.-I. … Bonventre J.V. (EMBO J. 2001) 2 3 4 67
  2. TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors. (PMID: 19152710) Cheong J.K. … Hsu S.I. (J Transl Med 2009) 3 23
  3. CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. (PMID: 18316374) Cheong J.K. … Hsu S.I. (J. Biol. Chem. 2008) 3 23
  4. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3
  5. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. (PMID: 23291629) Liew C.W. … Kulkarni R.N. (Nat. Med. 2013) 3

Products for SERTAD2 Gene

Sources for SERTAD2 Gene

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