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Aliases for SERTAD2 Gene

Aliases for SERTAD2 Gene

  • SERTA Domain Containing 2 2 3 5
  • Transcriptional Regulator Interacting With The PHS-Bromodomain 2 2 3
  • Transcriptional Regulator Interacting With The PHD-Bromodomain 2 3 4
  • TRIP-Br2 3 4
  • SERTA Domain-Containing Protein 2 3
  • KIAA0127 4
  • Sei-2 3

External Ids for SERTAD2 Gene

Previous GeneCards Identifiers for SERTAD2 Gene

  • GC02M064834
  • GC02M064770
  • GC02M064858

Summaries for SERTAD2 Gene

GeneCards Summary for SERTAD2 Gene

SERTAD2 (SERTA Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is CDCA4.

UniProtKB/Swiss-Prot for SERTAD2 Gene

  • Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERTAD2 Gene

Genomics for SERTAD2 Gene

Regulatory Elements for SERTAD2 Gene

Enhancers for SERTAD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F064830 1.8 FANTOM5 Ensembl ENCODE 24.5 -80.5 -80504 2.5 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF143 SERTAD2 RN7SL211P LOC102724233 SLC1A4 RAB1A LINC01800 ACTR2 AFTPH ENSG00000199964 GC02M064835
GH02F064635 1.5 FANTOM5 ENCODE 28.8 +103.1 103094 24.5 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 PPARGC1A SERTAD2 LOC102724233 AFTPH LOC105374775 RPS10P9
GH02F064857 1.5 FANTOM5 ENCODE 22.7 -110.8 -110794 8.7 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A ZNF143 ZNF263 PAF1 SP3 SERTAD2 ACTR2 AFTPH RAB1A SLC1A4 LINC01800 GC02P064841
GH02F064695 1.6 FANTOM5 Ensembl ENCODE 17.2 +52.9 52936 5.8 PKNOX1 ATF1 MLX ARID4B FEZF1 YY1 CBX5 ZNF143 FOS ZNF263 SERTAD2 SLC1A4 RAB1A PELI1 AFTPH GC02P064667
GH02F064665 1.4 FANTOM5 Ensembl ENCODE 17 +84.2 84184 3.8 SOX13 ELF3 SAP130 ARID4B RAD21 ZNF644 DNMT3B THRB RARA TEAD3 SERTAD2 AFTPH GC02P064667 RPS10P9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERTAD2 on UCSC Golden Path with GeneCards custom track

Promoters for SERTAD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001542986 691 3601 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for SERTAD2 Gene

Chromosome:
2
Start:
64,631,621 bp from pter
End:
64,751,091 bp from pter
Size:
119,471 bases
Orientation:
Minus strand

Genomic View for SERTAD2 Gene

Genes around SERTAD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERTAD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERTAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTAD2 Gene

Proteins for SERTAD2 Gene

  • Protein details for SERTAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14140-SRTD2_HUMAN
    Recommended name:
    SERTA domain-containing protein 2
    Protein Accession:
    Q14140
    Secondary Accessions:
    • Q53TS2

    Protein attributes for SERTAD2 Gene

    Size:
    314 amino acids
    Molecular mass:
    33897 Da
    Quaternary structure:
    • Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes.
    SequenceCaution:
    • Sequence=BAA09476.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SERTAD2 Gene

Post-translational modifications for SERTAD2 Gene

  • Polyubiquitinated, which promotes proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERTAD2 Gene

No data available for DME Specific Peptides for SERTAD2 Gene

Domains & Families for SERTAD2 Gene

Protein Domains for SERTAD2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERTAD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14140

UniProtKB/Swiss-Prot:

SRTD2_HUMAN :
  • Contains 1 SERTA domain.
Domain:
  • Contains 1 SERTA domain.
genes like me logo Genes that share domains with SERTAD2: view

No data available for Gene Families for SERTAD2 Gene

Function for SERTAD2 Gene

Molecular function for SERTAD2 Gene

UniProtKB/Swiss-Prot Function:
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.

Gene Ontology (GO) - Molecular Function for SERTAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IEA --
genes like me logo Genes that share ontologies with SERTAD2: view
genes like me logo Genes that share phenotypes with SERTAD2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERTAD2 Gene

Localization for SERTAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERTAD2 Gene

Nucleus. Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERTAD2 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for SERTAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16098148
GO:0005737 cytoplasm IDA 16098148
genes like me logo Genes that share ontologies with SERTAD2: view

Pathways & Interactions for SERTAD2 Gene

SuperPathways for SERTAD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERTAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030308 negative regulation of cell growth IDA 16098148
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SERTAD2: view

No data available for Pathways by source and SIGNOR curated interactions for SERTAD2 Gene

Transcripts for SERTAD2 Gene

Unigene Clusters for SERTAD2 Gene

SERTA domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD2 Gene

No ASD Table

Relevant External Links for SERTAD2 Gene

GeneLoc Exon Structure for
SERTAD2
ECgene alternative splicing isoforms for
SERTAD2

Expression for SERTAD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERTAD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERTAD2 Gene:

SERTAD2

SOURCE GeneReport for Unigene cluster for SERTAD2 Gene:

Hs.591569

mRNA Expression by UniProt/SwissProt for SERTAD2 Gene:

Q14140-SRTD2_HUMAN
Tissue specificity: Expressed in adipose tissue.
genes like me logo Genes that share expression patterns with SERTAD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SERTAD2 Gene

Orthologs for SERTAD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERTAD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERTAD2 34 35
  • 99.58 (n)
mouse
(Mus musculus)
Mammalia Sertad2 34 16 35
  • 87.4 (n)
rat
(Rattus norvegicus)
Mammalia Sertad2 34
  • 87.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SERTAD2 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERTAD2 34 35
  • 81.79 (n)
cow
(Bos Taurus)
Mammalia SERTAD2 34 35
  • 81 (n)
oppossum
(Monodelphis domestica)
Mammalia SERTAD2 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERTAD2 34 35
  • 80.24 (n)
lizard
(Anolis carolinensis)
Reptilia SERTAD2 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sertad2 34
  • 75.19 (n)
Str.19163 34
zebrafish
(Danio rerio)
Actinopterygii sertad2b 34 35
  • 68.54 (n)
Species where no ortholog for SERTAD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERTAD2 Gene

ENSEMBL:
Gene Tree for SERTAD2 (if available)
TreeFam:
Gene Tree for SERTAD2 (if available)

Paralogs for SERTAD2 Gene

Paralogs for SERTAD2 Gene

genes like me logo Genes that share paralogs with SERTAD2: view

Variants for SERTAD2 Gene

Sequence variations from dbSNP and Humsavar for SERTAD2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10164939 -- 64,740,385(+) aatat(A/T)tatat intron-variant
rs10165929 -- 64,675,154(+) ATCCC(A/C)AAAAA intron-variant
rs10168760 -- 64,653,883(+) CGGTA(C/G)GTCGT intron-variant, utr-variant-5-prime
rs10168939 -- 64,653,884(+) GGTAC(C/G)TCGTG intron-variant, utr-variant-5-prime
rs10178429 -- 64,737,052(+) AAAAA(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERTAD2 Gene

Variant ID Type Subtype PubMed ID
nsv820222 CNV loss 19587683
nsv7313 OTHER inversion 18451855
nsv582127 CNV gain 21841781
nsv2756 CNV deletion 18451855

Variation tolerance for SERTAD2 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERTAD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERTAD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERTAD2 Gene

Disorders for SERTAD2 Gene

Relevant External Links for SERTAD2

Genetic Association Database (GAD)
SERTAD2
Human Genome Epidemiology (HuGE) Navigator
SERTAD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERTAD2

No disorders were found for SERTAD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERTAD2 Gene

Publications for SERTAD2 Gene

  1. CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. (PMID: 18316374) Cheong J.K. … Hsu S.I. (J. Biol. Chem. 2008) 3 4 22 64
  2. TRIP-Br: a novel family of PHD zinc finger- and bromodomain- interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PMID: 11331592) Hsu S.-I. … Bonventre J.V. (EMBO J. 2001) 2 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4 64
  4. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. (PMID: 23291629) Liew C.W. … Kulkarni R.N. (Nat. Med. 2013) 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for SERTAD2 Gene

Sources for SERTAD2 Gene

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