Aliases for SERTAD2 Gene
Aliases for SERTAD2 Gene
External Ids for SERTAD2 Gene
- HGNC: 30784
- Entrez Gene: 9792
- Ensembl: ENSG00000179833
- UniProtKB: Q14140
Previous GeneCards Identifiers for SERTAD2 Gene
- GC02M064834
- GC02M064770
- GC02M064858
Summaries for SERTAD2 Gene
GeneCards Summary for SERTAD2 Gene
SERTAD2 (SERTA Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is CDCA4.
UniProtKB/Swiss-Prot for SERTAD2 Gene
-
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.
Additional gene information for SERTAD2 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERTAD2 Gene
Genomics for SERTAD2 Gene
GeneHancer (GH) Regulatory Elements for SERTAD2 Gene
Promoters and enhancers for SERTAD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SERTAD2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SERTAD2 Gene
Genomic Locations for SERTAD2 Gene
- chr2:64,631,621-64,751,091
- (GRCh38/hg38)
- Size:
- 119,471 bases
- Orientation:
- Minus strand
- chr2:64,858,755-64,978,139
- (GRCh37/hg19)
Genomic View for SERTAD2 Gene
Genes around SERTAD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p14 by Ensembl
- 2p14 by Entrez Gene
- 2p14 by HGNC
SERTAD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SERTAD2 Gene
Proteins for SERTAD2 Gene
-
Protein details for SERTAD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14140-SRTD2_HUMAN
- Recommended name:
- SERTA domain-containing protein 2
- Protein Accession:
- Q14140
- Q53TS2
Protein attributes for SERTAD2 Gene
- Size:
- 314 amino acids
- Molecular mass:
- 33897 Da
- Quaternary structure:
-
- Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes.
- SequenceCaution:
-
- Sequence=BAA09476.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Post-translational modifications for SERTAD2 Gene
- Polyubiquitinated, which promotes proteasomal degradation.
Other Protein References for SERTAD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SERTAD2
-
Abcam antibodies for SERTAD2
- Invitrogen Antibodies for SERTAD2
- GeneTex SERTAD2 antibody for SERTAD2
Protein Products
-
OriGene Purified Proteins for SERTAD2
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- antibodies-online: Search results for 4 available SERTAD2 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for SERTAD2
Assay Products
No data available for DME Specific Peptides for SERTAD2 Gene
Domains & Families for SERTAD2 Gene
Gene Families for SERTAD2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for SERTAD2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for SERTAD2 Gene
Function for SERTAD2 Gene
Molecular function for SERTAD2 Gene
- UniProtKB/Swiss-Prot Function:
- Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.
Phenotypes From GWAS Catalog for SERTAD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003713 | transcription coactivator activity | IEA | -- |
Phenotypes for SERTAD2 Gene
- MGI mutant phenotypes for SERTAD2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SERTAD2:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for SERTAD2 gene
-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERTAD2
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miRNA for SERTAD2 Gene
- miRTarBase miRNAs that target SERTAD2
-
- hsa-mir-210-3p (MIRT003157)
- hsa-mir-155-5p (MIRT005095)
- hsa-mir-151a-5p (MIRT019527)
- hsa-mir-340-5p (MIRT019555)
- hsa-mir-375 (MIRT019769)
- hsa-mir-124-3p (MIRT022235)
- hsa-mir-183-5p (MIRT025013)
- hsa-mir-7-5p (MIRT025710)
- hsa-mir-98-5p (MIRT027470)
- hsa-mir-93-5p (MIRT027995)
- hsa-mir-33a-5p (MIRT028231)
- hsa-mir-296-3p (MIRT038482)
- hsa-mir-6875-3p (MIRT089205)
- hsa-mir-324-5p (MIRT206988)
- hsa-mir-1277-5p (MIRT243203)
- hsa-mir-5011-5p (MIRT243207)
- hsa-mir-190a-3p (MIRT329165)
- hsa-mir-4778-3p (MIRT389212)
- hsa-mir-205-5p (MIRT439675)
- hsa-mir-6781-5p (MIRT468523)
- hsa-mir-4532 (MIRT468524)
- hsa-mir-6850-3p (MIRT468525)
- hsa-mir-1247-3p (MIRT468526)
- hsa-mir-4659b-3p (MIRT546529)
- hsa-mir-4659a-3p (MIRT546530)
- hsa-mir-4799-5p (MIRT546531)
- hsa-mir-4662a-3p (MIRT546532)
- hsa-mir-5692a (MIRT546533)
- hsa-mir-4531 (MIRT565753)
- hsa-mir-3911 (MIRT565754)
- hsa-mir-7847-3p (MIRT565755)
- hsa-mir-5703 (MIRT565756)
- hsa-mir-4516 (MIRT565757)
- hsa-mir-4434 (MIRT565758)
- hsa-mir-7153-5p (MIRT565759)
- hsa-mir-146b-5p (MIRT565760)
- hsa-mir-146a-5p (MIRT565761)
- hsa-mir-4302 (MIRT565762)
- hsa-mir-216a-3p (MIRT565763)
- hsa-mir-128-3p (MIRT565764)
- hsa-mir-3681-3p (MIRT565765)
- hsa-mir-92b-3p (MIRT726624)
- hsa-mir-32-5p (MIRT726625)
- hsa-mir-92a-3p (MIRT726626)
- hsa-mir-134-5p (MIRT737510)
- hsa-mir-3118 (MIRT739947)
- hsa-mir-3136-5p (MIRT740149)
- hsa-mir-31-5p (MIRT740504)
- hsa-mir-4427 (MIRT744298)
- hsa-mir-4439 (MIRT744510)
- hsa-mir-4468 (MIRT744937)
- hsa-mir-4513 (MIRT745690)
- hsa-mir-6809-5p (MIRT756637)
- hsa-mir-6855-3p (MIRT757683)
- hsa-mir-6857-3p (MIRT757750)
- hsa-mir-7151-5p (MIRT759187)
- hsa-mir-7855-5p (MIRT759959)
- hsa-mir-2681-5p (MIRT784349)
- hsa-mir-616-3p (MIRT788101)
- hsa-mir-924 (MIRT789949)
miRNA Products
- Search ViGene Biosciences for SERTAD2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SERTAD2
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- genomics-online: shRNA clones - Search results for available SERTAD2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SERTAD2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SERTAD2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SERTAD2 gene related products
- orf clones - Search results for available SERTAD2 gene related products
- Applied Biological Materials Clones for SERTAD2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SERTAD2
-
ViGene Biosciences adenoviral particle packaged cDNA for SERTAD2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SERTAD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SERTAD2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERTAD2 Gene
Localization for SERTAD2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SERTAD2 Gene
- Nucleus. Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 16098148 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA | 16098148 |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for SERTAD2 Gene
No Data Available
Interacting Proteins for SERTAD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0030308 | negative regulation of cell growth | IDA | 16098148 |
| GO:0045893 | positive regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SERTAD2 Gene
Transcripts for SERTAD2 Gene
mRNA/cDNA for SERTAD2 Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (206) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SERTAD2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SERTAD2
- genomics-online: gRNA clones - Search results for available SERTAD2 gene related products
- Applied Biological Materials CRISPR for SERTAD2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERTAD2
- GenScript: Design CRISPR guide RNA sequences for SERTAD2
miRNA Products
- Search ViGene Biosciences for SERTAD2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SERTAD2
- Browse OriGene Inhibitory RNA Products For SERTAD2
- genomics-online: shRNA clones - Search results for available SERTAD2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SERTAD2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SERTAD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SERTAD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SERTAD2 gene related products
- orf clones - Search results for available SERTAD2 gene related products
- Applied Biological Materials Clones for SERTAD2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SERTAD2 Gene
NURSA nuclear receptor signaling pathways regulating expression of SERTAD2 Gene:
SERTAD2SOURCE GeneReport for Unigene cluster for SERTAD2 Gene:
Hs.591569mRNA Expression by UniProt/SwissProt for SERTAD2 Gene:
Q14140-SRTD2_HUMAN
Tissue specificity:
Expressed in adipose tissue.
Evidence on tissue expression from TISSUES for SERTAD2 Gene
- Bone marrow(4.3)
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for SERTAD2
-
OriGene qPCR primer pairs and template standards for SERTAD2
- genomics-online: primer clones - Search results for available SERTAD2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERTAD2 Gene
Orthologs for SERTAD2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SERTAD2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Sertad2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Sertad2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SERTAD2 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SERTAD2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SERTAD2 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SERTAD2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SERTAD2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SERTAD2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sertad2 33 |
|
||
| Str.19163 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | sertad2b 33 34 |
|
- Species where no ortholog for SERTAD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SERTAD2 Gene
Variants for SERTAD2 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000021054 | -- | 64,689,849(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000043617 | -- | 64,658,830(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000051080 | -- | 64,654,065(-) | CCGGCCGCGGCCGC/ | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000112622 | -- | 64,738,416(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000123227 | -- | 64,686,353(-) | G/A | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.76;
16.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SERTAD2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SERTAD2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERTAD2 Gene
Disorders for SERTAD2 Gene
Additional Disease Information for SERTAD2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SERTAD2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERTAD2 Gene
Publications for SERTAD2 Gene
- CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. (PMID: 18316374) Cheong JK … Hsu SI (The Journal of biological chemistry 2008) 3 4 22 58
- TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PMID: 11331592) Hsu SI … Bonventre JV (The EMBO journal 2001) 2 3 4 58
- Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4 58
- Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. (PMID: 23291629) Liew CW … Kulkarni RN (Nature medicine 2013) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
Products for SERTAD2 Gene
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for SERTAD2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for SERTAD2
- VectorBuilder custom plasmid, inducible vectors for SERTAD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SERTAD2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 48 available SERTAD2 Antibodies ranked by validation data
- Compare Top SERTAD2 Antibodies
- antibodies-online: Search results for available SERTAD2 related products ranked by validation data
- antibodies-online: Search results for 4 available SERTAD2 Proteins ranked by validation data
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- Quality Products:
- GeneTex SERTAD2 antibody for SERTAD2
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- ViGene Biosciences adenoviral particle packaged cDNA for SERTAD2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SERTAD2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SERTAD2 gene
- Search ViGene Biosciences for SERTAD2
- Horizon Cell Lines for SERTAD2
- genomics-online: cdna clones - Search results for available SERTAD2 gene related products
- orf clones - Search results for available SERTAD2 gene related products
- genomics-online: gRNA clones - Search results for available SERTAD2 gene related products
- genomics-online: primer clones - Search results for available SERTAD2 gene related products
- genomics-online: shRNA clones - Search results for available SERTAD2 gene related products
Sources for SERTAD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
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