SERTAD2 Gene
protein-coding GIFtS: 47
GCID: GC02M064770
|
|
SERTA domain containing 2
| |
Aliases
for SERTAD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SERTA Domain Containing 21 2 | | Transcriptional Regulator Interacting With The PHD-Bromodomain 22 3 | | TRIP-Br21 2 3 | | SERTA Domain-Containing Protein 22 | | Sei-21 2 | | Transcriptional Regulator Interacting With The PHS-Bromodomain 22 | | KIAA01271 3 | | |
Export aliases for SERTAD2 gene to outside databasesPrevious GC identifers: GC02M064834 GC02M064592 |
Summaries
for SERTAD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SRTD2_HUMAN, Q14140Function: Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containingtranscription factors (By similarity)
|
Genomic Views
for SERTAD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SERTAD2 gene promoter:
Nkx3-1 Nkx3-1 v4 Olf-1 POU6F1 (c2) Nkx3-1 v1 GATA-1 Evi-1 Nkx3-1 v2 GATA-6 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for SERTAD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERTAD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p14 Ensembl cytogenetic band: 2p14 HGNC cytogenetic band: 2p15SERTAD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M064770: view genomic region
(about GC identifiers)
Start:
|
64,858,755 bp from pter |
End:
|
64,977,449 bp from pter |
Size:
|
118,695 bases |
Orientation:
|
minus strand |
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Proteins
for SERTAD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SRTD2_HUMAN, Q14140 (See
protein sequence)Recommended Name: SERTA domain-containing protein 2 Size: 314 amino acids; 33897 Da
Sequence caution: Sequence=BAA09476.2; Type=Erroneous initiation;
Secondary accessions: Q53TS2Explore the universe of human proteins at neXtProt for SERTAD2: NX_Q14140
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14140
SERTAD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055570.1
ENSEMBL proteins: ENSP00000326933
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SERTAD2 for ontologies About GeneDecksing
SERTAD2 Antibody Products:
Assay Products for SERTAD2: |
Protein
Domains /
Families
for SERTAD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SERTAD2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q14140ProtoNet protein and cluster: Q14140 1 Blocks protein family: IPB009263 SERTA
UniProtKB/Swiss-Prot: SRTD2_HUMAN, Q14140Similarity: Contains 1 SERTA domain |
Function
for SERTAD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SRTD2_HUMAN, Q14140Function: Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containingtranscription factors (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERTAD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERTAD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERTAD2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003713 | transcription coactivator activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
SERTAD2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for SERTAD2:
Animal Models:
1 MGI phenotypic allele  for Sertad2 (no phenotypes)
SERTAD2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SERTAD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERTAD2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/10 Interacting proteins for SERTAD2 (Q141403 ENSP000003269334) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0030308 | negative regulation of cell growth |
IDA | 16098148 | | GO:0045893 | positive regulation of transcription, DNA-dependent |
IEA | -- |
SERTAD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SERTAD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SERTAD2
Search CenterWatch for drugs/clinical trials and news about SERTAD2 / SRTD2
|
Transcripts
for SERTAD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SERTAD2 gene: NM_014755.2 Unigene Cluster for SERTAD2: SERTA domain containing 2 Hs.591569 [show with all ESTs]Unigene Representative Sequence: NM_0147552 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000313349(uc002sde.2) ENST00000476805
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERTAD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERTAD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SERTAD2 (NM_014755) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERTAD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERTAD2 |
Additional cDNA sequence: AK311117.1 BC074788.2 BC074789.2 BC101639.1 BC101641.1 D50917.1 8 DOTS entries: DT.418700 DT.99982477 DT.87014249 DT.95366098 DT.91754772 DT.100060546 DT.100681863 DT.75149815 24/206 AceView cDNA sequences (see all 206): BF061406 AI675041 W03762 AI032472 AU134908 BQ014466 AI538863 AA810121 AI075890 AA126386 AI167615 BE328016 AI276657 AA312838 D50917 AA902590 AA126268 BQ215809 H89759 AI335745 AA644291 AI589236 BU150508 AA283647
GeneLoc Exon Structure
|
Expression
for SERTAD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SERTAD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SERTAD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SERTAD2
SOURCE GeneReport for Unigene cluster: Hs.591569
SABiosciences Custom PCR Arrays for SERTAD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERTAD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERTAD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERTAD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERTAD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERTAD2 |
Orthologs
for SERTAD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SERTAD2 gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SERTAD21 |
SERTA domain containing 2 |
80.24(n)
81.41(a) |
|
421276 NM_001031037.1 NP_001026208.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SERTAD26 |
-- |
80(a) |
1 ↔ 1 |
1(124150447-124151406) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ087056.12 |
-- |
87.72(n) |
|
BJ087056.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
sertad2b1 |
SERTA domain containing 2b |
68.51(n)
67.1(a) |
|
368888 NM_212794.1 NP_997959.1 |
ENSEMBL Gene Tree for SERTAD2 (if available)
TreeFam Gene Tree for SERTAD2 (if available) |
Paralogs
for SERTAD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SERTAD2 gene
- CDCA42
SERTAD2 for paralogs About GeneDecksing
|
Genomic Variants
for SERTAD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SERTAD2 (64858755 - 64977449 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SERTAD2
1 CNV: 5025
1 Indel: 58997 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SERTAD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SERTAD2 for disorders About MalaCards
SERTAD2 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SERTAD2 (1 document)
Export disorders for SERTAD2 gene to outside databases
|
Publications
for SERTAD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SERTAD2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SERTAD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T....Nomura N. (1995)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- TRIP-Br: a novel family of PHD zinc finger- and bromodomain- interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PubMed id 11331592)1, 3 Hsu S.-I....Bonventre J.V. (2001)
- TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors. (PubMed id 19152710)1, 9 Cheong J.K....Hsu S.I. (2009)
- CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. (PubMed id 18316374)1, 9 Cheong J.K....Hsu S.I. (2008)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for SERTAD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SERTAD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SERTAD2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SERTAD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SERTAD2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SERTAD2 gene:
Search GeneIP for patents involving SERTAD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SERTAD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERTAD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERTAD2 | | | OriGene Protein Over-expression Lysate for SERTAD2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SERTAD2 | | OriGene 3'-UTR Clone for SERTAD2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERTAD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERTAD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SERTAD2 | | OriGene Custom Protein Services for SERTAD2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERTAD2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERTAD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERTAD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERTAD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERTAD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERTAD2 |
| |
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| |  |  |  |  | | | | |
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 | | | SERTAD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERTAD2 |
|  |  |  | | | | Search ThermoFisher Antibodies for SERTAD2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERTAD2 |
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