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Aliases for SERTAD1 Gene

Aliases for SERTAD1 Gene

  • SERTA Domain Containing 1 2 3 5
  • Transcriptional Regulator Interacting With The PHD-Bromodomain 1 2 3 4
  • CDK4-Binding Protein P34SEI1 3 4
  • CDK4-Binding Protein P34SEI 2 3
  • TRIP-Br1 3 4
  • SEI-1 3 4
  • SEI1 3 4
  • SERTA Domain-Containing Protein 1 3

External Ids for SERTAD1 Gene

Previous GeneCards Identifiers for SERTAD1 Gene

  • GC19M045621
  • GC19M045619
  • GC19M040928
  • GC19M037363

Summaries for SERTAD1 Gene

GeneCards Summary for SERTAD1 Gene

SERTAD1 (SERTA Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SERTAD1 Gene

  • Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.

Gene Wiki entry for SERTAD1 Gene

Additional gene information for SERTAD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERTAD1 Gene

Genomics for SERTAD1 Gene

GeneHancer (GH) Regulatory Elements for SERTAD1 Gene

Promoters and enhancers for SERTAD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I040420 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 552.1 +2.4 2448 6.6 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC ZNF610 SERTAD1 CCDC97 SERTAD3 ITPKC HNRNPUL1 SNRPA ENSG00000269843 FBL ZNF780B AKT2
GH19I040462 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 12 -39.2 -39187 4.5 CLOCK FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 BLVRB SPTBN4 ENSG00000269843 SNRPA HNRNPUL1 ZNF780B AKT2 CCDC97 FBL SERTAD3
GH19I040365 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.1 +59.0 59049 3.3 HDGF PKNOX1 ATF1 SIN3A POLR2B GLIS2 RUNX3 SP3 REST GLIS1 PLD3 ENSG00000206925 SERTAD1 SERTAD3 TTC9B HIPK4 PRX MIR6796 ENSG00000279759
GH19I041321 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -899.3 -899286 8.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF526 HNRNPUL1 SNRPA ENSG00000269843 CCDC97 TGFB1 CIC RPS19 NUMBL COQ8B
GH19I040054 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 8.9 +370.1 370066 2.3 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF302 E2F8 ZNF780B ZNF780A SNRPA ENSG00000269843 SERTAD3 SUPT5H COQ8B CYP2G1P PAK4 FBL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERTAD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERTAD1 gene promoter:

Genomic Locations for SERTAD1 Gene

Genomic Locations for SERTAD1 Gene
chr19:40,421,592-40,426,025
(GRCh38/hg38)
Size:
4,434 bases
Orientation:
Minus strand
chr19:40,927,499-40,931,932
(GRCh37/hg19)

Genomic View for SERTAD1 Gene

Genes around SERTAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERTAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERTAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTAD1 Gene

Proteins for SERTAD1 Gene

  • Protein details for SERTAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHV2-SRTD1_HUMAN
    Recommended name:
    SERTA domain-containing protein 1
    Protein Accession:
    Q9UHV2
    Secondary Accessions:
    • Q9BUE7

    Protein attributes for SERTAD1 Gene

    Size:
    236 amino acids
    Molecular mass:
    24704 Da
    Quaternary structure:
    • Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Interacts with E2F1 and TFDP1; modulates transactivation activity of TFDP1/E2F complexes. Also interacts with CDK4.

neXtProt entry for SERTAD1 Gene

Post-translational modifications for SERTAD1 Gene

Other Protein References for SERTAD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERTAD1 Gene

Domains & Families for SERTAD1 Gene

Gene Families for SERTAD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SERTAD1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SERTAD1: view

No data available for UniProtKB/Swiss-Prot for SERTAD1 Gene

Function for SERTAD1 Gene

Molecular function for SERTAD1 Gene

UniProtKB/Swiss-Prot Function:
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.

Phenotypes From GWAS Catalog for SERTAD1 Gene

Gene Ontology (GO) - Molecular Function for SERTAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SERTAD1: view
genes like me logo Genes that share phenotypes with SERTAD1: view

Animal Models for SERTAD1 Gene

MGI Knock Outs for SERTAD1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERTAD1 Gene

Localization for SERTAD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERTAD1 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SERTAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SERTAD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SERTAD1 Gene

Pathways & Interactions for SERTAD1 Gene

SuperPathways for SERTAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERTAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 6434876
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation TAS 6434876
GO:0030308 negative regulation of cell growth IDA --
genes like me logo Genes that share ontologies with SERTAD1: view

No data available for Pathways by source and SIGNOR curated interactions for SERTAD1 Gene

Drugs & Compounds for SERTAD1 Gene

No Compound Related Data Available

Transcripts for SERTAD1 Gene

mRNA/cDNA for SERTAD1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(115) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERTAD1 Gene

SERTA domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD1 Gene

No ASD Table

Relevant External Links for SERTAD1 Gene

GeneLoc Exon Structure for
SERTAD1
ECgene alternative splicing isoforms for
SERTAD1

Expression for SERTAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERTAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERTAD1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERTAD1 Gene



Protein tissue co-expression partners for SERTAD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERTAD1 Gene:

SERTAD1

SOURCE GeneReport for Unigene cluster for SERTAD1 Gene:

Hs.269898
genes like me logo Genes that share expression patterns with SERTAD1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERTAD1 Gene

Orthologs for SERTAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERTAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERTAD1 33 34
  • 98.45 (n)
dog
(Canis familiaris)
Mammalia SERTAD1 33 34
  • 88.28 (n)
cow
(Bos Taurus)
Mammalia SERTAD1 33 34
  • 87.29 (n)
mouse
(Mus musculus)
Mammalia Sertad1 33 16 34
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia Sertad1 33
  • 80.79 (n)
oppossum
(Monodelphis domestica)
Mammalia SERTAD1 34
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERTAD1 34
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERTAD1 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sertad1 33
  • 53.55 (n)
Species where no ortholog for SERTAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERTAD1 Gene

ENSEMBL:
Gene Tree for SERTAD1 (if available)
TreeFam:
Gene Tree for SERTAD1 (if available)

Paralogs for SERTAD1 Gene

No data available for Paralogs for SERTAD1 Gene

Variants for SERTAD1 Gene

Sequence variations from dbSNP and Humsavar for SERTAD1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000462710 -- 40,427,297(-) G/A upstream_transcript_variant
rs1000563814 -- 40,427,013(-) C/G upstream_transcript_variant
rs1000932809 -- 40,425,627(-) G/A intron_variant
rs1001006398 -- 40,425,803(-) C/G intron_variant
rs1001132506 -- 40,425,100(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERTAD1 Gene

Variant ID Type Subtype PubMed ID
nsv833831 CNV loss 17160897

Variation tolerance for SERTAD1 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERTAD1 Gene

Human Gene Mutation Database (HGMD)
SERTAD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERTAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERTAD1 Gene

Disorders for SERTAD1 Gene

Additional Disease Information for SERTAD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SERTAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERTAD1 Gene

Publications for SERTAD1 Gene

  1. Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). (PMID: 10580009) Sugimoto M … Hara E (Genes & development 1999) 2 3 4 22 58
  2. Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A). (PMID: 16201750) Li J … Tsai MD (Biochemistry 2005) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PMID: 11331592) Hsu SI … Bonventre JV (The EMBO journal 2001) 3 4 58
  5. Acid esterase deficiency: comparison of biochemical findings in infantile and adult forms. (PMID: 6434876) Besley GT … Lawlor E (Journal of inherited metabolic disease 1984) 2 3 58

Products for SERTAD1 Gene

Sources for SERTAD1 Gene

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