Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERTAD1 Gene

Aliases for SERTAD1 Gene

  • SERTA Domain Containing 1 2 3 5
  • Transcriptional Regulator Interacting With The PHD-Bromodomain 1 2 3 4
  • CDK4-Binding Protein P34SEI1 3 4
  • CDK4-Binding Protein P34SEI 2 3
  • TRIP-Br1 3 4
  • SEI-1 3 4
  • SEI1 3 4

External Ids for SERTAD1 Gene

Previous GeneCards Identifiers for SERTAD1 Gene

  • GC19M045621
  • GC19M045619
  • GC19M040928
  • GC19M037363

Summaries for SERTAD1 Gene

GeneCards Summary for SERTAD1 Gene

SERTAD1 (SERTA Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SERTAD1 Gene

  • Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.

Gene Wiki entry for SERTAD1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERTAD1 Gene

Genomics for SERTAD1 Gene

Regulatory Elements for SERTAD1 Gene

Enhancers for SERTAD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SERTAD1 on UCSC Golden Path with GeneCards custom track

Promoters for SERTAD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SERTAD1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SERTAD1 gene promoter:

Genomic Location for SERTAD1 Gene

Chromosome:
19
Start:
40,421,592 bp from pter
End:
40,426,025 bp from pter
Size:
4,434 bases
Orientation:
Minus strand

Genomic View for SERTAD1 Gene

Genes around SERTAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERTAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERTAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTAD1 Gene

Proteins for SERTAD1 Gene

  • Protein details for SERTAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHV2-SRTD1_HUMAN
    Recommended name:
    SERTA domain-containing protein 1
    Protein Accession:
    Q9UHV2
    Secondary Accessions:
    • Q9BUE7

    Protein attributes for SERTAD1 Gene

    Size:
    236 amino acids
    Molecular mass:
    24704 Da
    Quaternary structure:
    • Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Interacts with E2F1 and TFDP1; modulates transactivation activity of TFDP1/E2F complexes. Also interacts with CDK4.

neXtProt entry for SERTAD1 Gene

Proteomics data for SERTAD1 Gene at MOPED

Post-translational modifications for SERTAD1 Gene

Other Protein References for SERTAD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERTAD1 Gene

Domains & Families for SERTAD1 Gene

Protein Domains for SERTAD1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UHV2

UniProtKB/Swiss-Prot:

SRTD1_HUMAN :
  • Contains 1 SERTA domain.
Domain:
  • Contains 1 SERTA domain.
genes like me logo Genes that share domains with SERTAD1: view

No data available for Gene Families for SERTAD1 Gene

Function for SERTAD1 Gene

Molecular function for SERTAD1 Gene

UniProtKB/Swiss-Prot Function:
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.
genes like me logo Genes that share phenotypes with SERTAD1: view

Animal Models for SERTAD1 Gene

MGI Knock Outs for SERTAD1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SERTAD1 Gene

Localization for SERTAD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERTAD1 Gene COMPARTMENTS Subcellular localization image for SERTAD1 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SERTAD1 Gene

Pathways & Interactions for SERTAD1 Gene

SuperPathways for SERTAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERTAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 6434876
GO:0008284 positive regulation of cell proliferation TAS 6434876
GO:0045893 positive regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with SERTAD1: view

No data available for Pathways by source and SIGNOR curated interactions for SERTAD1 Gene

Drugs & Compounds for SERTAD1 Gene

No Compound Related Data Available

Transcripts for SERTAD1 Gene

mRNA/cDNA for SERTAD1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(115) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERTAD1 Gene

SERTA domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD1 Gene

No ASD Table

Relevant External Links for SERTAD1 Gene

GeneLoc Exon Structure for
SERTAD1
ECgene alternative splicing isoforms for
SERTAD1

Expression for SERTAD1 Gene

mRNA expression in normal human tissues for SERTAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERTAD1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERTAD1 Gene



SOURCE GeneReport for Unigene cluster for SERTAD1 Gene Hs.269898

genes like me logo Genes that share expression patterns with SERTAD1: view

Protein tissue co-expression partners for SERTAD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SERTAD1 Gene

Orthologs for SERTAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERTAD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SERTAD1 35
  • 87.29 (n)
  • 90.25 (a)
SERTAD1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERTAD1 35
  • 88.28 (n)
  • 91.1 (a)
SERTAD1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sertad1 35
  • 83.33 (n)
  • 86.44 (a)
Sertad1 16
Sertad1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERTAD1 35
  • 98.45 (n)
  • 97.88 (a)
SERTAD1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sertad1 35
  • 80.79 (n)
  • 83.9 (a)
oppossum
(Monodelphis domestica)
Mammalia SERTAD1 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERTAD1 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERTAD1 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sertad1 35
  • 53.55 (n)
  • 44.26 (a)
Species with no ortholog for SERTAD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERTAD1 Gene

ENSEMBL:
Gene Tree for SERTAD1 (if available)
TreeFam:
Gene Tree for SERTAD1 (if available)

Paralogs for SERTAD1 Gene

No data available for Paralogs for SERTAD1 Gene

Variants for SERTAD1 Gene

Sequence variations from dbSNP and Humsavar for SERTAD1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs268687 - 40,423,456(-) GCCAC(A/G)CAGCG reference, missense
rs8102079 -- 40,426,027(+) CTACC(C/T)TTAGC upstream-variant-2KB
rs8102098 -- 40,426,121(+) TTCTG(A/C)AGGAG upstream-variant-2KB
rs140122572 -- 40,423,291(+) CAGGG(C/T)AGCCG reference, missense
rs140827966 -- 40,422,005(+) TAGTC(A/G)GTCCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SERTAD1 Gene

Variant ID Type Subtype PubMed ID
nsv833831 CNV Loss 17160897
dgv3867n71 CNV Loss 21882294
nsv911709 CNV Loss 21882294

Variation tolerance for SERTAD1 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERTAD1 Gene

HapMap Linkage Disequilibrium report
SERTAD1
Human Gene Mutation Database (HGMD)
SERTAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERTAD1 Gene

Disorders for SERTAD1 Gene

Relevant External Links for SERTAD1

Genetic Association Database (GAD)
SERTAD1
Human Genome Epidemiology (HuGE) Navigator
SERTAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERTAD1

No disorders were found for SERTAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERTAD1 Gene

Publications for SERTAD1 Gene

  1. Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI- 1). (PMID: 10580009) Sugimoto M. … Hara E. (Genes Dev. 1999) 2 3 4 23 67
  2. Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A). (PMID: 16201750) Li J. … Tsai M.D. (Biochemistry 2005) 3 23
  3. Acid esterase deficiency: comparison of biochemical findings in infantile and adult forms. (PMID: 6434876) Besley G.T. … Lawlor E. (J. Inherit. Metab. Dis. 1984) 2 3
  4. Nutrient/serum starvation derived TRIP-Br3 down-regulation accelerates apoptosis by destabilizing XIAP. (PMID: 25691055) Li C. … Lee M.S. (Oncotarget 2015) 3
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3

Products for SERTAD1 Gene

Sources for SERTAD1 Gene

Content