SERTAD1 Gene
protein-coding GIFtS: 50
GCID: GC19M040928
|
|
SERTA domain containing 1
| |
Aliases
for SERTAD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SERTA Domain Containing 11 2 | | SEI-12 3 | | SEI11 2 3 | | CDK4-Binding Protein P34SEI12 3 | | TRIP-Br11 2 3 | | CDK4-Binding Protein P34SEI2 | | Transcriptional Regulator Interacting With The PHD-Bromodomain 12 3 | | SERTA Domain-Containing Protein 12 |
Export aliases for SERTAD1 gene to outside databasesPrevious GC identifers: GC19M045621 GC19M045619 GC19M037363 |
Summaries
for SERTAD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SRTD1_HUMAN, Q9UHV2Function: Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containingtranscription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4resistant to the inhibitory effects of p16(INK4a)
Gene Wiki entry for SERTAD1
|
Genomic Views
for SERTAD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SERTAD1 gene promoter:
COUP-TF p53 COUP
Other transcription factors
Search SABiosciences Chromatin IP Primers for SERTAD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERTAD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.1-q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1-q13.2SERTAD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M040928: view genomic region
(about GC identifiers)
Start:
|
40,927,499 bp from pter |
End:
|
40,931,932 bp from pter |
Size:
|
4,434 bases |
Orientation:
|
minus strand |
|
Proteins
for SERTAD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SRTD1_HUMAN, Q9UHV2 (See
protein sequence)Recommended Name: SERTA domain-containing protein 1 Size: 236 amino acids; 24704 Da
Subunit: Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Binds to DP1. Also interacts with CDK4
Secondary accessions: Q9BUE7Explore the universe of human proteins at neXtProt for SERTAD1: NX_Q9UHV2
SERTAD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037508.2
ENSEMBL proteins: ENSP00000350633
Human Recombinant Protein Products:
SERTAD1 Antibody Products:
Assay Products for SERTAD1: |
Protein
Domains /
Families
for SERTAD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SERTAD1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UHV2ProtoNet protein and cluster: Q9UHV2 1 Blocks protein family: IPB009263 SERTA
UniProtKB/Swiss-Prot: SRTD1_HUMAN, Q9UHV2Similarity: Contains 1 SERTA domain |
Function
for SERTAD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SRTD1_HUMAN, Q9UHV2Function: Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containingtranscription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4resistant to the inhibitory effects of p16(INK4a)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERTAD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERTAD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SERTAD1 (NM_013376) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERTAD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERTAD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERTAD1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
SERTAD1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SERTAD1:
Animal Models:
Mouse knock-out Sertad1tm1Srn for SERTAD1
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Sertad1):
SERTAD1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SERTAD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERTAD1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/46 Interacting proteins for SERTAD1 (Q9UHV21, 2, 3 ENSP000003506334) via UniProtKB, MINT, STRING, and/or I2D (see all 46)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000079 | regulation of cyclin-dependent protein kinase activity |
TAS | 6434876 | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0008284 | positive regulation of cell proliferation |
TAS | 6434876 | | GO:0045893 | positive regulation of transcription, DNA-dependent |
IEA | -- |
SERTAD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SERTAD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SERTAD1
Search CenterWatch for drugs/clinical trials and news about SERTAD1 / SRTD1
|
Transcripts
for SERTAD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SERTAD1 gene: NM_013376.3 Unigene Cluster for SERTAD1: SERTA domain containing 1 Hs.269898 [show with all ESTs]Unigene Representative Sequence: AK0746521 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000357949(uc002ont.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERTAD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERTAD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SERTAD1 (NM_013376) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERTAD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERTAD1 |
Additional cDNA sequence: AF117959.1 AF366402.1 AK074652.1 AK222970.1 AK223011.1 BC002670.2 2 DOTS entries: DT.414100 DT.95316673 24/115 AceView cDNA sequences (see all 115): AI342377 BM973302 AA642241 BU633212 BQ182938 BU538362 AA928491 AK074652 BQ771685 AW957102 BU957131 BU078730 CB851800 BM673506 BU539198 CD364905 AI659129 AW071086 BU856974 AA719658 BU537987 BX101521 AI955492 BC002670
GeneLoc Exon Structure
|
Expression
for SERTAD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SERTAD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGTGCTGG
About this image
See SERTAD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SERTAD1
SOURCE GeneReport for Unigene cluster: Hs.269898
SABiosciences Expression via Pathway-Focused PCR Array including SERTAD1: | Cell Cycle in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERTAD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERTAD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERTAD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERTAD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERTAD1 |
Orthologs
for SERTAD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SERTAD1 gene from 2/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
50(a) |
1 → many |
LGf(2157487-2158176) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ059948.12 |
-- |
75.07(n) |
|
BJ059948.1 |
ENSEMBL Gene Tree for SERTAD1 (if available)
TreeFam Gene Tree for SERTAD1 (if available) |
Paralogs
for SERTAD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SERTAD1 gene
- SERTAD32
SERTAD1 for paralogs About GeneDecksing
|
Genomic Variants
for SERTAD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SERTAD1 (40927499 - 40931932 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SERTAD1: --
Human Gene Mutation Database (HGMD): SERTAD1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERTAD1 |
|
Disorders
/ Diseases
for SERTAD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SERTAD1 for disorders About GeneDecksing
5  diseases for SERTAD1: About MalaCardsesophageal cancer esophagitis colorectal cancer breast cancer
ataxia
Human Genome Epidemiology (HuGE) Navigator: SERTAD1 (2 documents)
Export disorders for SERTAD1 gene to outside databases
|
Publications
for SERTAD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SERTAD1 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with SERTAD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI- 1). (PubMed id 10580009)1, 2, 3, 9 Sugimoto M.... Hara E. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- TRIP-Br: a novel family of PHD zinc finger- and bromodomain- interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PubMed id 11331592)1, 2 Hsu S.-I....Bonventre J.V. (2001)
- Acid esterase deficiency: comparison of biochemical findings in infantile and adult forms. (PubMed id 6434876)1, 3 Besley G.T....Lawlor E. (1984)
- Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A). (PubMed id 16201750)1, 9 Li J....Tsai M.D. (2005)
- Effect of PP2A on p34SEI-1 expression in response to ionizing radiation in MCF-7 human breast cancer cells. (PubMed id 21344158)1 Jung S....Lee M.S. (2011)
- p34 (SEI-1) inhibits ROS-induced cell death through s uppression of ASK1. (PubMed id 21725208)1 Hong S.W....Lee W.K. (2011)
- Characterization of a novel mechanism of genomic inst ability involving the SEI1/SET/NM23H1 pathway in esophageal cancers. (PubMed id 20570897)1 Li Y....Guan X.Y. (2010)
- An integrative method for scoring candidate genes fro m association studies: application to warfarin dosing. (PubMed id 21044367)1 Tatonetti N.P....Altman R.B. (2010)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
|
External Searches for SERTAD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SERTAD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SERTAD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SERTAD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SERTAD1 | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/sei1/ |
|
| | |
About This Section
| Patent Information for SERTAD1 gene:
Search GeneIP for patents involving SERTAD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SERTAD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SERTAD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERTAD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERTAD1 | | | OriGene Protein Over-expression Lysate for SERTAD1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SERTAD1 | | OriGene 3'-UTR Clone for SERTAD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERTAD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERTAD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SERTAD1 | | OriGene Custom Protein Services for SERTAD1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERTAD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERTAD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERTAD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERTAD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERTAD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERTAD1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SERTAD1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SERTAD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERTAD1 |
|  |  |  | | | | ThermoFisher Antibodies for SERTAD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERTAD1 |
|
|
|
|
