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Aliases for SERPINI2 Gene

Aliases for SERPINI2 Gene

  • Serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2 2 3
  • PI14 3 4 6
  • MEPI 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade I (Neuroserpin), Member 2 2 3
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade I (Pancpin), Member 2 2 3
  • Myoepithelium-Derived Serine Protease Inhibitor 3 4
  • Pancreas-Specific Protein TSA2004 3 4
  • Peptidase Inhibitor 14 3 4
  • PANCPIN 3 4
  • Protease Inhibitor 14 3
  • Serpin I2 3
  • SERPIN12 6
  • TSA2004 3
  • PI-14 4

External Ids for SERPINI2 Gene

Previous HGNC Symbols for SERPINI2 Gene

  • PI14

Previous GeneCards Identifiers for SERPINI2 Gene

  • GC03M164449
  • GC03M168213
  • GC03M168561
  • GC03M168480
  • GC03M168642
  • GC03M167156

Summaries for SERPINI2 Gene

Entrez Gene Summary for SERPINI2 Gene

  • The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for SERPINI2 Gene

SERPINI2 (Serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

Gene Wiki entry for SERPINI2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINI2 Gene

Genomics for SERPINI2 Gene

Regulatory Elements for SERPINI2 Gene

Genomic Location for SERPINI2 Gene

167,441,789 bp from pter
167,479,004 bp from pter
37,216 bases
Minus strand

Genomic View for SERPINI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINI2 Gene

Proteins for SERPINI2 Gene

  • Protein details for SERPINI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serpin I2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SERPINI2 Gene

    405 amino acids
    Molecular mass:
    46145 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH27859.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SERPINI2 Gene

Proteomics data for SERPINI2 Gene at MOPED

Post-translational modifications for SERPINI2 Gene

  • Glycosylation at Asn202, Asn207, and Asn306
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINI2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SERPINI2

No data available for DME Specific Peptides for SERPINI2 Gene

Domains for SERPINI2 Gene

Gene Families for SERPINI2 Gene

  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINI2 Gene


Suggested Antigen Peptide Sequences for SERPINI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O75830
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINI2: view

Function for SERPINI2 Gene

Gene Ontology (GO) - Molecular Function for SERPINI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SERPINI2: view
genes like me logo Genes that share phenotypes with SERPINI2: view

Animal Model Products

CRISPR Products

miRNA for SERPINI2 Gene

miRTarBase miRNAs that target SERPINI2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINI2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SERPINI2 Gene

Localization for SERPINI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINI2 Gene


Subcellular locations from

Jensen Localization Image for SERPINI2 Gene COMPARTMENTS Subcellular localization image for SERPINI2 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SERPINI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SERPINI2: view

Pathways for SERPINI2 Gene

SuperPathways for SERPINI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERPINI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 10097100
GO:0010951 negative regulation of endopeptidase activity IBA --
GO:0030155 regulation of cell adhesion IEA --
GO:0030162 regulation of proteolysis --
genes like me logo Genes that share ontologies with SERPINI2: view

No data available for Pathways by source for SERPINI2 Gene

Transcripts for SERPINI2 Gene

Unigene Clusters for SERPINI2 Gene

Serpin peptidase inhibitor, clade I (pancpin), member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINI2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINI2 Gene

No ASD Table

Relevant External Links for SERPINI2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERPINI2 Gene

mRNA expression in normal human tissues for SERPINI2 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINI2 Gene

This gene is overexpressed in Pancreas (50.5).

Protein differential expression in normal tissues for SERPINI2 Gene

This gene is overexpressed in Pancreatic juice (32.1), Pancreas (24.8), and Fetal gut (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINI2 Gene

SOURCE GeneReport for Unigene cluster for SERPINI2 Gene Hs.445555

mRNA Expression by UniProt/SwissProt for SERPINI2 Gene

Tissue specificity: Expressed in pancreas and adipose tissues.
genes like me logo Genes that share expressions with SERPINI2: view

Expression partners for SERPINI2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SERPINI2 Gene

Orthologs for SERPINI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINI2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SERPINI2 35
  • 88.89 (n)
  • 84.94 (a)
  • 85 (a)
(Canis familiaris)
Mammalia SERPINI2 35
  • 89.47 (n)
  • 84.2 (a)
  • 79 (a)
(Mus musculus)
Mammalia Serpini2 35
  • 82.44 (n)
  • 76.73 (a)
Serpini2 16
Serpini2 36
  • 76 (a)
(Pan troglodytes)
Mammalia SERPINI2 35
  • 99.42 (n)
  • 99.26 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Serpini2 35
  • 83.46 (n)
  • 77.49 (a)
(Monodelphis domestica)
Mammalia SERPINI2 36
  • 65 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia serpini2 35
  • 67.96 (n)
  • 57.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta nec 37
  • 27 (a)
Spn2 37
  • 29 (a)
Spn43Aa 37
  • 28 (a)
Spn43Ab 37
  • 26 (a)
Spn6 37
  • 31 (a)
nec 36
  • 21 (a)
Spn1 36
  • 31 (a)
Spn2 36
  • 31 (a)
Spn28Da 36
  • 25 (a)
Spn28Db 36
  • 26 (a)
Spn3 36
  • 30 (a)
Spn4 36
  • 25 (a)
Spn42Db 36
  • 26 (a)
Spn42Dc 36
  • 24 (a)
Spn42De 36
  • 27 (a)
Spn43Aa 36
  • 26 (a)
Spn43Ab 36
  • 25 (a)
Spn47C 36
  • 23 (a)
Spn6 36
  • 29 (a)
Spn7 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea srp-1 37
  • 26 (a)
srp-6 37
  • 31 (a)
srp-7 37
  • 31 (a)
Species with no ortholog for SERPINI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINI2 Gene

Gene Tree for SERPINI2 (if available)
Gene Tree for SERPINI2 (if available)

Paralogs for SERPINI2 Gene

genes like me logo Genes that share paralogs with SERPINI2: view

Variants for SERPINI2 Gene

Sequence variations from dbSNP and Humsavar for SERPINI2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs961069 -- 167,460,905(+) ACAAC(A/C)GAAAC intron-variant
rs1104570 -- 167,450,209(+) TCACC(A/T)GTTAC intron-variant
rs1916350 -- 167,475,760(+) GCCAA(C/G)GTGTC upstream-variant-2KB
rs2272138 -- 167,446,399(+) GTTGG(A/G)TTATG synonymous-codon, reference
rs2272139 -- 167,446,531(+) ATCAG(A/T)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINI2 Gene

Variant ID Type Subtype PubMed ID
nsv877969 CNV Loss 21882294

Relevant External Links for SERPINI2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINI2 Gene

Disorders for SERPINI2 Gene

Relevant External Links for SERPINI2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SERPINI2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SERPINI2 Gene

Publications for SERPINI2 Gene

  1. Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells. (PMID: 9624529) Ozaki K. … Nakamura Y. (Genes Chromosomes Cancer 1998) 2 3 4 23
  2. Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26. (PMID: 10992299) Chang W.S. … Wu F.Y. (Genes Chromosomes Cancer 2000) 3 23
  3. Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells. (PMID: 10097100) Xiao G. … Shi Y.E. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 48

Products for SERPINI2 Gene

Sources for SERPINI2 Gene

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