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SERPINI2 Gene

protein-coding   GIFtS: 58
GCID: GC03M167156

Serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2

(Previous names: serine (or cysteine) proteinase inhibitor, clade I (neuroserpin),...)
(Previous symbol: PI14)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serpin Peptidase Inhibitor, Clade I (Pancpin), Member 21 2     PANCPIN2
PI141 2 3 5     TSA20042
MEPI2 3 5     Protease Inhibitor 142
Serine (Or Cysteine) Proteinase Inhibitor, Clade I (Neuroserpin), Member 21 2     Serpin I22
Serine (Or Cysteine) Proteinase Inhibitor, Clade I (Pancpin), Member 21 2     PI-143
Myoepithelium-Derived Serine Protease Inhibitor2 3     Pancpin3
Pancreas-Specific Protein TSA20042 3     SERPIN125
Peptidase Inhibitor 142 3     

External Ids:    HGNC: 89451   Entrez Gene: 52762   Ensembl: ENSG000001142047   OMIM: 6055875   UniProtKB: O758303   

Export aliases for SERPINI2 gene to outside databases

Previous GC identifers: GC03M164449 GC03M168213 GC03M168561 GC03M168480 GC03M168642


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SERPINI2 Gene:
The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins
function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis,
development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during
pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. (provided
by RefSeq, Jan 2013)

GeneCards Summary for SERPINI2 Gene:
SERPINI2 (serpin peptidase inhibitor, clade I (pancpin), member 2) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB7.

Gene Wiki entry for SERPINI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERPINI2 gene promoter:
         E2F-3a   E2F-4   E2F-5   CUTL1   E2F-2   GATA-1   E2F-1   E2F   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINI2 promoter sequence
   Search Chromatin IP Primers for SERPINI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERPINI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.1   Ensembl cytogenetic band:  3q26.1   HGNC cytogenetic band: 3q26.1

SERPINI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINI2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M167156:  view genomic region     (about GC identifiers)

Start:
167,159,577 bp from pter      End:
167,196,792 bp from pter
Size:
37,216 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPI2_HUMAN, O75830 (See protein sequence)
Recommended Name: Serpin I2 precursor  
Size: 405 amino acids; 46145 Da
Sequence caution: Sequence=AAH27859.2; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for SERPINI2: NX_O75830

Explore proteomics data for SERPINI2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn202, Asn207, Asn306
  • Modification sites at PhosphoSitePlus

  • See SERPINI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001012303.1  NP_006208.1  

    ENSEMBL proteins: 
     ENSP00000420621   ENSP00000417692   ENSP00000419407   ENSP00000417752   ENSP00000419255  
     ENSP00000264677  

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    Sino Biological Cell Lysate for SERPINI2
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    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Serpin_CS
     IPR000215 Serpin_fam
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry O75830

    ProtoNet protein and cluster: O75830

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: SPI2_HUMAN, O75830
    Similarity: Belongs to the serpin family


    Find genes that share domains with SERPINI2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with SERPINI2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERPINI2:
     Increased G2M DNA content, inc  Increased cell death HMECs cel 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Serpini2):
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system  immune system 
     mortality/aging 

    Find genes that share phenotypes with SERPINI2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERPINI2
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    miRNA
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    miRTarBase miRNAs that target SERPINI2:
    hsa-mir-26b-5p (MIRT029774)

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    1 qRT-PCR Assays for microRNA that regulate SERPINI2:
    hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidSERPINI2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPI2_HUMAN, O75830: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with SERPINI2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERPINI2
    Interactions:

        Search GeneGlobe Interaction Network for SERPINI2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for SERPINI2 (O758301, 2, 3 ENSP000002646774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN1Q9UMX01, 2, 3, ENSP000003655764EBI-750144,EBI-741480 MINT-67715 I2D: score=6 STRING: ENSP00000365576
    HBP1O603812, 3, ENSP000002225744MINT-2861759 I2D: score=1 STRING: ENSP00000222574
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2861740 I2D: score=3 STRING: ENSP00000357292
    SGTBQ96EQ03I2D: score=1 
    UBQLN2ENSP000003451954STRING: ENSP00000345195
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    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS10097100
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030155regulation of cell adhesion IEA--
    GO:0030162regulation of proteolysis IBA--

    Find genes that share ontologies with SERPINI2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERPINI2 (SPI2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SERPINI2 gene (2 alternative transcripts): 
    NM_001012303.2  NM_006217.4  

    Unigene Cluster for SERPINI2:

    Serpin peptidase inhibitor, clade I (pancpin), member 2
    Hs.445555  [show with all ESTs]
    Unigene Representative Sequence: NM_001012303
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476257 ENST00000461846(uc003fes.1) ENST00000471111 ENST00000495108
    ENST00000466903 ENST00000467583 ENST00000465031 ENST00000264677(uc003fer.1 uc003fet.1)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SERPINI2:
    hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidSERPINI2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB006423.1 AK226025.1 AK293391.1 BC027859.2 

    5 DOTS entries:

    DT.92420101  DT.100755123  DT.99933672  DT.100000999  DT.95159510 

    Selected AceView cDNA sequences (see all 34):

    BM091057 NM_006217 BM091362 BC027859 BX497612 BX497698 CA772296 BM353733 
    BM353460 BU580945 BI835563 BU580484 CA503150 AF130470 AB006423 BX496933 
    AL696968 BI834396 CA772010 BX497611 BX498583 AI972199 BG192641 BM983763 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERPINI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCTGGCTC
    SERPINI2 Expression
    About this image

    SERPINI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERPINI2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445555

    UniProtKB/Swiss-Prot: SPI2_HUMAN, O75830
    Tissue specificity: Expressed in pancreas and adipose tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SERPINI2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpini21 , 5 serine (or cysteine) peptidase inhibitor, clade I, more1, 5 82.44(n)1
    76.73(a)1
      3 (33.74 cM)5
    679311  NM_026460.31  NP_080736.21 
     752423705 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    many ↔ many
    GL343247.1(1727253-1737245)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia serpini21 serpin peptidase inhibitor, clade I (pancpin), member more 67.96(n)
    57.99(a)
      548471  NM_001015754.1  NP_001015754.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spn63 serpin 31(a)
    (best of 5)
      55B7   --


    ENSEMBL Gene Tree for SERPINI2 (if available)
    TreeFam Gene Tree for SERPINI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERPINI2 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINB22  SERPINB102  SERPINB32  
    SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINB112  SERPINE32  
    SERPINB132  SERPINB82  
    Selected SIMAP similar genes for SERPINI2 using alignment to 3 protein entries:     SPI2_HUMAN (see all proteins) (see all similar genes):
    SCCA1    SERPINI1    SERPINB11    SERPINB3    SERPINA2    SERPINA5
    SERPINB1    SERPINB5    SERPINB6    SERPINA1    SERPINA3    SERPINA9
    SERPINE2    SCCA2    SERPINA11    SERPINB13    SERPINB7    SERPINE1

    Find genes that share paralogs with SERPINI2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERPINI2 (see all 794)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1180402031,2
    F--167159081(+) ATGAAG/CTAATA 2 -- ds50011Minor allele frequency- C:0.01EA 120
    rs1144836031,2
    C,F--167159141(+) TTCAAG/AGGAAG 2 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1867142481,2
    C--167159167(+) CTTTAC/TAGTGC 2 -- ds50010--------
    rs738812161,2
    C,F--167159203(+) GGCTCG/AGTATT 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1150411661,2
    C,F--167159209(+) GTATTG/ATAAAA 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1165358741,2
    F--167159301(+) TCAGCA/CTTTCT 2 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1810740101,2
    C--167159311(+) TATGTC/TGTGTA 2 -- ds50010--------
    rs771783241,2
    F--167159450(+) TGCAAG/AGAATA 2 -- ds50011Minor allele frequency- A:0.07NA 120
    rs124947031,2
    C,F,H--167159568(+) TAGTCT/GAGTAT 2 -- ds50017Minor allele frequency- G:0.05EA NS WA NA 530
    rs1460101181,2
    C--167159657(+) GAATGC/GTAATA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SERPINI2 (167159577 - 167196792 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SERPINI2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877969CNV Loss21882294

    Human Gene Mutation Database (HGMD): SERPINI2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SERPINI2
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605587    OMIM disorders: --


    Find genes that share disorders with SERPINI2           About GenesLikeMe

    Genetic Association Database (GAD): SERPINI2
    Human Genome Epidemiology (HuGE) Navigator: SERPINI2 (1 document)

    Export disorders for SERPINI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERPINI2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with SERPINI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells. (PubMed id 9624529)1, 2, 3, 9 Ozaki K.... Nakamura Y. (Genes Chromosomes Cancer 1998)
    2. Update of the human and mouse SERPIN gene superfamily. (PubMed id 24172014)1, 3 Heit C....Vasiliou V. (Hum. Genomics 2013)
    3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells. (PubMed id 10097100)1, 2 Xiao G....Shi Y.E. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    6. Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26. (PubMed id 10992299)1, 9 Chang W.S....Wu F.Y. (amp 2000)
    7. Common polymorphisms in the SERPINI2 gene are associated with refractive error in the 1958 British Birth Cohort. (PubMed id 22110064)1 Hysi P.G....Rahi J.S. (amp 2012)
    8. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
    9. Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia. (PubMed id 19641524)1 Farfsing A....Pscherer A. (Leukemia 2009)
    10. The role of serpins in the surveillance of the secretory pathway. (PubMed id 17668148)1 Ragg H. (Cell. Mol. Life Sci. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5276 HGNC: 8945 AceView: SERPINI2 Ensembl:ENSG00000114204 euGenes: HUgn5276
    ECgene: SERPINI2 H-InvDB: SERPINI2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERPINI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERPINI2 Genetics and Cytogenetics in Oncology and Haematology

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    Patent Information for SERPINI2 gene:
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