Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERPINF2 Gene

Aliases for SERPINF2 Gene

  • Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 2 2 3
  • Alpha-2-Plasmin Inhibitor 2 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 2 2 3
  • Alpha-2-Antiplasmin 2 3
  • ALPHA-2-PI 3 4
  • Alpha-2-AP 3 4
  • Serpin F2 3 4
  • PLI 3 4
  • AAP 3 4
  • A2AP 3
  • PLI, 6
  • API 3

External Ids for SERPINF2 Gene

Previous HGNC Symbols for SERPINF2 Gene

  • PLI

Previous GeneCards Identifiers for SERPINF2 Gene

  • GC17P001921
  • GC17P001982
  • GC17P001596
  • GC17P001852
  • GC17P001824
  • GC17P001593
  • GC17P001646

Summaries for SERPINF2 Gene

Entrez Gene Summary for SERPINF2 Gene

  • This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for SERPINF2 Gene

SERPINF2 (Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 2) is a Protein Coding gene. Diseases associated with SERPINF2 include alpha-2-plasmin inhibitor deficiency and congenital alpha2 antiplasmin deficiency. Among its related pathways are Hemostasis and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include protein homodimerization activity and protease binding. An important paralog of this gene is SERPINA10.

UniProtKB/Swiss-Prot for SERPINF2 Gene

  • Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.

Gene Wiki entry for SERPINF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINF2 Gene

Genomics for SERPINF2 Gene

Regulatory Elements for SERPINF2 Gene

Genomic Location for SERPINF2 Gene

Start:
1,742,721 bp from pter
End:
1,755,268 bp from pter
Size:
12,548 bases
Orientation:
Plus strand

Genomic View for SERPINF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINF2 Gene

Proteins for SERPINF2 Gene

  • Protein details for SERPINF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08697-A2AP_HUMAN
    Recommended name:
    Alpha-2-antiplasmin
    Protein Accession:
    P08697
    Secondary Accessions:
    • B4E1B7
    • Q8N5U7
    • Q9UCG2
    • Q9UCG3

    Protein attributes for SERPINF2 Gene

    Size:
    491 amino acids
    Molecular mass:
    54566 Da
    Quaternary structure:
    • Forms protease inhibiting heterodimer with TMPRSS7

    Alternative splice isoforms for SERPINF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINF2 Gene

Proteomics data for SERPINF2 Gene at MOPED

Post-translational modifications for SERPINF2 Gene

  • Proteolytically cleaved at Pro-39 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin.
  • Glycosylation at Asn126, Asn295, Asn309, and Asn316
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINF2 Gene

Antibody Products

  • R&D Systems Antibodies for SERPINF2 (Serpin F2/alpha 2-Antiplasmin)

No data available for DME Specific Peptides for SERPINF2 Gene

Domains for SERPINF2 Gene

Gene Families for SERPINF2 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINF2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINF2 Gene

Graphical View of Domain Structure for InterPro Entry

P08697

UniProtKB/Swiss-Prot:

A2AP_HUMAN :
  • P08697
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINF2: view

Function for SERPINF2 Gene

Molecular function for SERPINF2 Gene

UniProtKB/Swiss-Prot Function: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.

Gene Ontology (GO) - Molecular Function for SERPINF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 134998
GO:0004866 endopeptidase inhibitor activity TAS 2830248
GO:0004867 serine-type endopeptidase inhibitor activity NAS 12878203
GO:0005515 protein binding IPI 12878203
GO:0042803 protein homodimerization activity IPI 134998
genes like me logo Genes that share ontologies with SERPINF2: view

Phenotypes for SERPINF2 Gene

MGI mutant phenotypes for SERPINF2:
inferred from 1 alleles
GenomeRNAi human phenotypes for SERPINF2:
genes like me logo Genes that share phenotypes with SERPINF2: view

Animal Models for SERPINF2 Gene

MGI Knock Outs for SERPINF2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINF2 Gene

Localization for SERPINF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINF2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINF2 Gene COMPARTMENTS Subcellular localization image for SERPINF2 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SERPINF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005577 fibrinogen complex IDA 17317851
GO:0005615 extracellular space IDA 6980881
GO:0009986 cell surface IDA 17958745
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with SERPINF2: view

Pathways for SERPINF2 Gene

genes like me logo Genes that share pathways with SERPINF2: view

Pathways by source for SERPINF2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SERPINF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002034 regulation of blood vessel size by renin-angiotensin ISS --
GO:0002576 platelet degranulation TAS --
GO:0006953 acute-phase response IEA --
GO:0007596 blood coagulation TAS --
GO:0010033 response to organic substance IEA --
genes like me logo Genes that share ontologies with SERPINF2: view

Compounds for SERPINF2 Gene

(1) Drugbank Compounds for SERPINF2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ocriplasmin
1048016-9-6 target ligand

(36) Novoseek inferred chemical compound relationships for SERPINF2 Gene

Compound -log(P) Hits PubMed IDs
fibrinogen 89.8 143
epsilon aminocaproic acid 78.4 8
eaca 66.8 4
fibrinopeptide a 63.5 2
aprotinin 56.3 13
genes like me logo Genes that share compounds with SERPINF2: view

Transcripts for SERPINF2 Gene

Unigene Clusters for SERPINF2 Gene

Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: -
SP2:
SP3: - - - -
SP4:

Relevant External Links for SERPINF2 Gene

GeneLoc Exon Structure for
SERPINF2
ECgene alternative splicing isoforms for
SERPINF2

Expression for SERPINF2 Gene

mRNA expression in normal human tissues for SERPINF2 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINF2 Gene

This gene is overexpressed in Liver (40.4) and Kidney - Cortex (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINF2 Gene

SOURCE GeneReport for Unigene cluster for SERPINF2 Gene Hs.159509

mRNA Expression by UniProt/SwissProt for SERPINF2 Gene

P08697-A2AP_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expressions with SERPINF2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SERPINF2 Gene

Orthologs for SERPINF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINF2 35
  • 94.12 (n)
  • 93.5 (a)
SERPINF2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINF2 35
  • 85.53 (n)
  • 80.17 (a)
SERPINF2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINF2 35
  • 86.42 (n)
  • 81.67 (a)
SERPINF2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinf2 35
  • 81.19 (n)
  • 74.54 (a)
Serpinf2 16
Serpinf2 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERPINF2 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINF2 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpinf2 35
  • 81.19 (n)
  • 73.12 (a)
chicken
(Gallus gallus)
Aves SERPINF2 35
  • 60.54 (n)
  • 54.42 (a)
SERPINF2 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serpinf2 35
  • 56.16 (n)
  • 48.37 (a)
zebrafish
(Danio rerio)
Actinopterygii serpinf2a 35
  • 50.19 (n)
  • 44.44 (a)
serpinf2a 36
  • 36 (a)
OneToMany
serpinf2b 36
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Spn27A 36
  • 23 (a)
ManyToMany
Spn5 36
  • 22 (a)
ManyToMany
Spn88Eb 36
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
ManyToMany
CSA.10120 36
  • 23 (a)
ManyToMany
Species with no ortholog for SERPINF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINF2 Gene

ENSEMBL:
Gene Tree for SERPINF2 (if available)
TreeFam:
Gene Tree for SERPINF2 (if available)

Paralogs for SERPINF2 Gene

Selected SIMAP similar genes for SERPINF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SERPINF2: view

Variants for SERPINF2 Gene

Sequence variations from dbSNP and Humsavar for SERPINF2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3976 -- 1,749,797(-) TGGGC(C/T)CTTGT intron-variant
rs736060 -- 1,752,921(+) GGAGC(A/G)GGGAG intron-variant
rs1057335 - 1,754,359(+) CGTGA(A/G)GAACC missense, reference
rs1057355 -- 1,754,605(+) CAACC(G/T)GCTTT utr-variant-3-prime
rs1135399 -- 1,755,243(+) ATGCC(A/C)CCTGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SERPINF2 Gene

Variant ID Type Subtype PubMed ID
nsv907511 CNV Loss 21882294
nsv9490 CNV Loss 18304495
nsv470568 CNV Loss 18288195
nsv516886 CNV Loss 19592680
dgv3033n71 CNV Loss 21882294
nsv833335 CNV Gain+Loss 17160897
nsv1946 CNV Insertion 18451855
esv2663369 CNV Deletion 23128226
nsv907521 CNV Gain 21882294
esv2715481 CNV Deletion 23290073
esv2667330 CNV Deletion 23128226

Relevant External Links for SERPINF2 Gene

HapMap Linkage Disequilibrium report
SERPINF2
Human Gene Mutation Database (HGMD)
SERPINF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINF2 Gene

Disorders for SERPINF2 Gene

(1) OMIM Diseases for SERPINF2 Gene (613168)

UniProtKB/Swiss-Prot

A2AP_HUMAN
  • Alpha-2-plasmin inhibitor deficiency (APLID) [MIM:262850]: An autosomal recessive disorder resulting in severe hemorrhagic diathesis. {ECO:0000269 PubMed:10583218, ECO:0000269 PubMed:2572590}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(43) Novoseek inferred disease relationships for SERPINF2 Gene

Disease -log(P) Hits PubMed IDs
disseminated intravascular coagulation 58.3 3
coagulopathy 58.3 3
thrombosis 54.6 4
platelet aggregation, spontaneous 54 2
venous occlusion 51.5 4

Relevant External Links for SERPINF2

Genetic Association Database (GAD)
SERPINF2
Human Genome Epidemiology (HuGE) Navigator
SERPINF2
genes like me logo Genes that share disorders with SERPINF2: view

Publications for SERPINF2 Gene

  1. Bovine alpha 2-antiplasmin. N-terminal and reactive site sequence. (PMID: 1385210) Christensen S. … Sottrup-Jensen L. (FEBS Lett. 1992) 3 4 23
  2. Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties. (PMID: 9169621) Christensen S. … Enghild J.J. (Biochem. J. 1997) 3 4 23
  3. A novel missense mutation in the human plasmin inhibitor (alpha2- antiplasmin) gene associated with a bleeding tendency. (PMID: 10583218) Lind B. … Thorsen S. (Br. J. Haematol. 1999) 3 4 48
  4. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  5. Assignment of the human alpha 2-plasmin inhibitor gene (PLI) to chromosome region 18p11.1----q11.2 by in situ hybridization. (PMID: 3416655) Kato A. … Aoki N. (Cytogenet. Cell Genet. 1988) 2 3

Products for SERPINF2 Gene

Sources for SERPINF2 Gene

Back to Top

Content