Aliases for SERPINF2 Gene
- Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 2 2 3
- Alpha-2-Plasmin Inhibitor 2 3 4
- Serine (Or Cysteine) Proteinase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 2 2 3
- Alpha-2-Antiplasmin 2 3
- ALPHA-2-PI 3 4
- Alpha-2-AP 3 4
- Serpin F2 3 4
External Ids for SERPINF2 Gene
Previous HGNC Symbols for SERPINF2 Gene
Previous GeneCards Identifiers for SERPINF2 Gene
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for SERPINF2 Gene
SERPINF2 (Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 2) is a Protein Coding gene. Diseases associated with SERPINF2 include alpha-2-plasmin inhibitor deficiency and congenital alpha2 antiplasmin deficiency. Among its related pathways are Hemostasis and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include protein homodimerization activity and protease binding. An important paralog of this gene is SERPINA10.
UniProtKB/Swiss-Prot for SERPINF2 Gene
Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.