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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SERPINF2 Gene

protein-coding GIFtS: 63
GCID: GC17P001593

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin,...

(Previous names: serine (or cysteine) proteinase inhibitor, clade F (alpha-2...)
(Previous symbol: PLI)

Explore 76 diseases affiliated with
SERPINF2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 2¹ ²		Alpha-2-Plasmin Inhibitor² ³
PLI¹ ² ³ ⁵		Serpin F2² ³
AAP¹ ² ³		Alpha-2-AP³
A2AP¹ ²		Alpha-2-Antiplasmin¹
ALPHA-2-PI¹ ²		Alpha-2-AP³
API¹ ²		Alpha-2-PI³
Serine (Or Cysteine) Proteinase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 2¹ ²

External Ids:	HGNC: 9075¹	Entrez Gene: 5345²	Ensembl: ENSG00000167711⁷	OMIM: 613168⁵	UniProtKB: P08697³

Export aliases for SERPINF2 gene to outside databases

Previous GC identifers: GC17P001921 GC17P001982 GC17P001596 GC17P001852 GC17P001824

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SERPINF2:

This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of

plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major

role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency,

which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have

been found for this gene. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: A2AP_HUMAN, P08697

Function: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also

inactivates matriptase-3/TMPRSS7 and chymotrypsin

Gene Wiki entry for SERPINF2 (Alpha 2-antiplasmin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SERPINF2 gene promoter:
GR p53 GR-beta CUTL1 E2F E2F-1 STAT3 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SERPINF2 promoter sequence

Search SABiosciences Chromatin IP Primers for SERPINF2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3

SERPINF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINF2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P001593: view genomic region (about GC identifiers)

Start:	1,646,130 bp from pter	End:	1,658,562 bp from pter
Size:	12,433 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: A2AP_HUMAN, P08697 (See protein sequence)

Recommended Name: Alpha-2-antiplasmin precursor

Size: 491 amino acids; 54566 Da

Subunit: Forms protease inhibiting heterodimer with TMPRSS7

Subcellular location: Secreted

Secondary accessions: B4E1B7 Q8N5U7 Q9UCG2 Q9UCG3

Alternative splicing: 2 isoforms: P08697-1 P08697-2

Explore the universe of human proteins at neXtProt for SERPINF2: NX_P08697

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08697

SERPINF2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_000925.2 NP_001159392.1 NP_001159393.1

ENSEMBL proteins:

ENSP00000402286 ENSP00000403877 ENSP00000402056 ENSP00000371493 ENSP00000321853

Reactome Protein details: P08697
Human Recombinant Protein Products:

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	Novus Biologicals SERPINF2 Protein Novus Biologicals SERPINF2 Lysates
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	Uscn Proteins for SERPINF2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005577	fibrinogen complex	IDA	17317851
GO:0005615	extracellular space	IDA	6980881
GO:0031093	platelet alpha granule lumen	TAS	--

SERPINF2 for ontologies About GeneDecksing

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	ThermoFisher Antibody for SERPINF2

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	Uscn ELISAs and CLIAs for SERPINF2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SERPINF2 for domains About GeneDecksing

3 InterPro domains/families:

IPR023795 Protease_inhib_I4_serpin_CS

IPR023796 Serpin_dom

IPR000215 Serpin_fam

Graphical View of Domain Structure for InterPro Entry P08697

ProtoNet protein and cluster: P08697

1 Blocks protein family: IPB000215 Serpin

UniProtKB/Swiss-Prot: A2AP_HUMAN, P08697

Similarity: Belongs to the serpin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: A2AP_HUMAN, P08697

Function: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also

inactivates matriptase-3/TMPRSS7 and chymotrypsin

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SERPINF2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINF2
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINF2 (see all 18):
		hsa-miR-3934 hsa-miR-125a-3p hsa-miR-520d-5p hsa-miR-764 hsa-miR-449a hsa-miR-1276 hsa-miR-34b hsa-miR-548c-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SERPINF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINF2 (see all 7) OriGene shRNA RFP: SERPINF2 OriGene siRNA: SERPINF2
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINF2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IPI	17317851
GO:0004866	endopeptidase inhibitor activity	TAS	2830248
GO:0004867	serine-type endopeptidase inhibitor activity	NAS	12878203
GO:0005515	protein binding	IPI	14687906
GO:0042803	protein homodimerization activity	IPI	134998

SERPINF2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SERPINF2:

Decreased nuclei size in G2M

Animal Models:
Mouse knock-out Serpinf2^tm1Hrl for SERPINF2
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Serpinf2):

homeostasis/metabolism

SERPINF2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Platelet degranulation

Platelet degranulation

1.00

Response to elevated platelet cytosolic Ca2+

0.94

Complement and coagulation cascades

Complement and coagulation cascades

1.00

Complement and Coagulation Cascades

0.72

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Formation of Fibrin Clot (Clotting Cascade)

Blood Coagulation Signaling Pathways

0.51

Blood Clotting Cascade

0.36

Expression of PAI-1

Dissolution of Fibrin Clot

0.10

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for SERPINF2

Blood Coagulation Signaling Pathways

2 BioSystems Pathways for SERPINF2

	Blood Clotting Cascade
	Complement and Coagulation Cascades

5 Reactome Pathways for SERPINF2

	Hemostasis
	Platelet degranulation
	Dissolution of Fibrin Clot
	Platelet activation, signaling and aggregation
	Response to elevated platelet cytosolic Ca2+

1 Kegg Pathway (Kegg details for SERPINF2):

Complement and coagulation cascades

SERPINF2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SERPINF2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/53 Interacting proteins for SERPINF2 (P08697³ ENSP00000321853⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 53)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DEFA1	P59665³, ENSP00000372126⁴	I2D: score=1 STRING: ENSP00000372126
F13A1	P00488³, ENSP00000264870⁴	I2D: score=2 STRING: ENSP00000264870
DEFA1B	P59665³	I2D: score=1
FGA	P02671³, ENSP00000306361⁴	I2D: score=1 STRING: ENSP00000306361
PLG	P00747³, ENSP00000308938⁴	I2D: score=2 STRING: ENSP00000308938

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002034	regulation of blood vessel size by renin-angiotensin	ISS	--
GO:0002576	platelet degranulation	TAS	--
GO:0006953	acute-phase response	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0010033	response to organic substance	IEA	--

SERPINF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SERPINF2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SERPINF2
10/36 Novoseek chemical compound relationships for SERPINF2 gene (see all 36) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	89.8	248	18564219 (5), 2125758 (4), 7692999 (3), 7529848 (3) (see all 99)
epsilon aminocaproic acid	78.4	12	15915719 (3), 17100317 (1), 1939207 (1), 18613223 (1) (see all 6)
eaca	66.8	4	9156934 (1), 1377955 (1), 11435135 (1), 18613223 (1)
fibrinopeptide a	63.5	3	7516205 (1), 7952409 (1)
aprotinin	56.3	14	12891467 (3), 7539609 (2), 1716481 (1), 7540230 (1) (see all 10)
ristocetin	50	2	17586991 (1)
kininogen	49.3	6	1391957 (1), 8738592 (1), 1466361 (1), 8400086 (1) (see all 6)
heparin	45	9	8770836 (1), 2365816 (1), 1391957 (1), 17655281 (1) (see all 6)
lysine	41.7	8	19257897 (2), 7549063 (1), 1703440 (1), 9765841 (1)
serine	36.7	1	1377955 (1)

Search CenterWatch for drugs/clinical trials and news about SERPINF2 / A2AP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SERPINF2 gene (3 alternative transcripts):

NM_000934.3 NM_001165920.1 NM_001165921.1

Unigene Cluster for SERPINF2:

Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

Hs.159509 [show with all ESTs]

Unigene Representative Sequence: NM_001165920

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000453066 ENST00000450523 ENST00000453723 ENST00000382061(uc021tnm.1)

ENST00000324015(uc002ftk.1 uc010vqr.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINF2
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINF2 (see all 18):
		hsa-miR-3934 hsa-miR-125a-3p hsa-miR-520d-5p hsa-miR-764 hsa-miR-449a hsa-miR-1276 hsa-miR-34b hsa-miR-548c-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SERPINF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINF2 (see all 7) OriGene shRNA RFP: SERPINF2 OriGene siRNA: SERPINF2
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Additional cDNA sequence:

AK124987.1 AK303763.1 BC031592.1 D00116.1 D00174.1 J02654.1

6 DOTS entries:

DT.95156337 DT.215147 DT.92423531 DT.101961546 DT.75102485 DT.95184530

24/98 AceView cDNA sequences (see all 98):

BX107460 R83021 AA910278 R29277 R29305 AI081521 AL531258 CR617307

CB157447 D00116 CB157473 BM546658 BX448893 AL564001 AL564479 R83072

CB240641 AL579976 AA343040 BX452421 AU121395 AI133160 BX448892 CB156019

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINF2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b
SP1:																					-
SP2:
SP3:													-		-		-				-
SP4:

ECgene alternative splicing isoforms for SERPINF2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SERPINF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTCCTTAA

About this image

SERPINF2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See SERPINF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SERPINF2

SOURCE GeneReport for Unigene cluster: Hs.159509

UniProtKB/Swiss-Prot: A2AP_HUMAN, P08697

Tissue specificity: Expressed by the liver and secreted in plasma

SABiosciences Expression via Pathway-Focused PCR Array including SERPINF2:

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINF2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERPINF2 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SERPINF2¹	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, more	60.54(n) 54.42(a)		100857105 XM_003642399.1 XP_003642447.1
zebrafish (Danio rerio)	Actinopterygii	serpinf2a¹	serine (or cysteine) peptidase inhibitor, clade F, more	48.36(n) 42.35(a)		560308 XM_683705.4 XP_688797.1
fruit fly (Drosophila melanogaster)	Insecta	Spn1⁶ Spn3⁶ (see all 26)	Serine protease inhibitor 3 (see all 26)	27(a) 27(a) (see all 26)	possible ortholog possible ortholog (see all 26)	2R(2770786-2772378) 2L(20836621-20838179)
worm (Caenorhabditis elegans)	Secernentea	srp-1⁶ srp-3⁶ (see all 6)	SeRPin family member (srp-3) (see all 6)	25(a) 24(a) (see all 6)	possible ortholog possible ortholog (see all 6)	V(753335-755049) V(1908895-1910691)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G25240⁶ AT1G47710⁶ (see all 10)	serpin-ZX (see all 10)	24(a) 24(a) (see all 10)	many ↔ many many ↔ many (see all 10)	2(10751768-10753134) 1(17558209-17560269)
rice (Oryza sativa)	Liliopsida	-- -- (see all 16)	serpin domain containing protein, putative, expres... serpin domain containing protein, putative, expres... (see all 16)	25(a) 24(a) (see all 16)	many ↔ many many ↔ many (see all 16)	3(23053071-23066803) 1(32248927-32250581)

ENSEMBL Gene Tree for SERPINF2 (if available)
TreeFam Gene Tree for SERPINF2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SERPINF2 gene

SERPING1² SERPINA1² SERPINH1² SERPINA10² SERPINA11² SERPINA7² SERPINA12² SERPINA9²

SERPINA5² SERPINF1² SERPIND1² SERPINA4² SERPINA3² SERPINA6²

3 SIMAP similar genes for SERPINF2 using alignment to 3 protein entries: A2AP_HUMAN (see all proteins):

SERPINB1 SERPINB11 SERPINB9

SERPINF2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs55695984^1,2	C	--	1541514(+)	`GGGAGA/GCGGCC`	3	--	us2k¹		0	--	--	--	--
rs112874281^1,2	C	--	1541514(+)	`GGGAGA/GCGGCC`	3	--	us2k¹		0	--	--	--	--
rs76839251^1,2	C	--	1541583(+)	`GAGGCG/ACAGGA`	3	--	us2k¹		3		NA	6
rs60157812^1,2	C	--	1541672(+)	`TGAGGC/AGCAGG`	3	--	us2k¹		1		NA	2
rs12936651^1,2	C	--	1541717(+)	`TGAGGC/AGCAGG`	3	--	us2k¹		1		NA	2
rs12944285^1,2	C	--	1541741(+)	`GAAGGG/AGCCTG`	3	--	us2k¹		1		NA	2
rs12936944^1,2	C	--	1541762(+)	`TGAGGC/AGCAGG`	3	--	us2k¹		2		NA	4
rs61243169^1,2	C,F	--	1541807(+)	`TGAGGC/AGCCGG`	3	--	us2k¹		2		NA	4
rs12937184^1,2	C	--	1541810(+)	`GGAGCC/AGGACA`	3	--	us2k¹		1		NA	2
rs190818900^1,2		--	1644431(+)	`GGAGCA/CGGACA`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SERPINF2 (1646130 - 1658562 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SERPINF2
5 CNVs: 49826 32148 30021 49827 35433
Human Gene Mutation Database (HGMD): SERPINF2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SERPINF2 for disorders           About GeneDecksing

OMIM gene information: 613168
OMIM disorders: 262850
UniProtKB/Swiss-Prot: A2AP_HUMAN, P08697

Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID) [MIM:262850]. APLID is an

autosomal recessive disorder resulting in severe hemorrhagic diathesis

20/76 diseases for SERPINF2 (see all 76): About MalaCards

plasmin inhibitor deficiency alpha-1-antichymotrypsin deficiency disseminated intravascular coagulation miller-dieker syndrome

thrombotic thrombocytopenic purpura acute poststreptococcal glomerulonephritis hereditary cerebral hemorrhage with amyloidosis abdominal aortic aneurysm

blood clots acute myocardial infarction pulmonary embolism hypofibrinogenemia

aortic aneurysm coronary heart disease myocardial infarction protein c deficiency

bullous pemphigoid cerebral hemorrhage polycystic ovary syndrome venous thrombosis

4 diseases from the University of Copenhagen DISEASES database for SERPINF2:

Disseminated intravascular coagulation Periodontal disease Acute myocardial infarction Vascular disease

10/43 Novoseek disease relationships for SERPINF2 gene (see all 43) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
disseminated intravascular coagulation	58.3	3	2202206 (1), 8481516 (1), 8710052 (1)
coagulopathy	58.3	3	8328647 (1), 2315889 (1), 1693328 (1)
thrombosis	54.6	4	7692999 (1), 7495059 (1), 11474570 (1), 17883703 (1)
platelet aggregation, spontaneous	54	2	1603102 (1), 1758145 (1)
venous occlusion	51.5	6	7618616 (1), 8059288 (1), 1563856 (1), 8444504 (1)
bleeding tendency	50.3	3	1615471 (1), 7549066 (1)
acute myocardial infarction	50.2	2	8261210 (1), 1691750 (1)
bleeding	49.3	26	7682569 (4), 7865673 (2), 18613223 (2), 2240694 (2) (see all 15)
hypofibrinogenemia	43	2	8157787 (1), 8710052 (1)
thrombophilia	42	1	7514043 (1)

Human Genome Epidemiology (HuGE) Navigator: SERPINF2 (5 documents)

Export disorders for SERPINF2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SERPINF2 gene, integrated from 9 sources (see all 400):
(articles sorted by number of sources associating them with SERPINF2)

Utopia: connect your pdf to the dynamic
world of online information

Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties. (PubMed id 9169621)^{1, 2, 9} Christensen S....Enghild J.J. (1997)
Bovine alpha 2-antiplasmin. N-terminal and reactive site sequence. (PubMed id 1385210)^{1, 2, 9} Christensen S. and Sottrup-Jensen L. (1992)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. (PubMed id 15853774)^{1, 2} Szabo R....Bugge T.H. (2005)
A novel missense mutation in the human plasmin inhibitor (alpha2- antiplasmin) gene associated with a bleeding tendency. (PubMed id 10583218)^{1, 2} Lind B. and Thorsen S. (1999)
Different N-terminal forms of alpha 2-plasmin inhibitor in human plasma. (PubMed id 8484741)^{1, 2} Bangert K.... Thorsen S. (1993)
Hereditary alpha 2-plasmin inhibitor deficiency caused by a transport-deficient mutation (alpha 2-PI-Okinawa). Deletion of Glu137 by a trinucleotide deletion blocks intracellular transport. (PubMed id 2572590)^{1, 2} Miura O.... Aoki N. (1989)
Assignment of the human alpha 2-plasmin inhibitor gene (PLI) to chromosome region 18p11.1----q11.2 by in situ hybridization. (PubMed id 3416655)^{1, 3} Kato A....Aoki N. (1988)
Organization of the human alpha 2-plasmin inhibitor gene. (PubMed id 3166140)^{1, 2} Hirosawa S.... Aoki N. (1988)
Alpha-2-antiplasmin: a serpin with two separate but overlapping reactive sites. (PubMed id 2456616)^{1, 2} Potempa J.... Travis J. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5345	HGNC: 9075	AceView: SERPINF2	Ensembl:ENSG00000167711	euGenes: HUgn5345
ECgene: SERPINF2	Kegg: 5345	H-InvDB: SERPINF2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SERPINF2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SERPINF2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SERPINF2 gene:
Search GeneIP for patents involving SERPINF2

GeneCards and IP:
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