Aliases for SERPINF1 Gene
- Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 2 3
- PEDF 3 4 6
- Serine (Or Cysteine) Proteinase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 2 3
- Cell Proliferation-Inducing Gene 35 Protein 3 4
- Pigment Epithelium-Derived Factor 2 3
- Serpin F1 3 4
External Ids for SERPINF1 Gene
Previous Symbols for SERPINF1 Gene
The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]
GeneCards Summary for SERPINF1 Gene
SERPINF1 (Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1) is a Protein Coding gene. Diseases associated with SERPINF1 include osteogenesis imperfecta, type vi and corneal neovascularization. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA10.
UniProtKB/Swiss-Prot for SERPINF1 Gene
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.