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Aliases for SERPINF1 Gene

Aliases for SERPINF1 Gene

  • Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 2 3
  • PEDF 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 2 3
  • Cell Proliferation-Inducing Gene 35 Protein 3 4
  • Pigment Epithelium-Derived Factor 2 3
  • Serpin F1 3 4
  • EPC-1 3 4
  • OI6 3 6
  • Proliferation-Inducing Protein 35 2
  • PIG35 3
  • OI12 3

External Ids for SERPINF1 Gene

Previous Symbols for SERPINF1 Gene

  • PEDF

Summaries for SERPINF1 Gene

Entrez Gene Summary for SERPINF1 Gene

  • The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]

GeneCards Summary for SERPINF1 Gene

SERPINF1 (Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1) is a Protein Coding gene. Diseases associated with SERPINF1 include osteogenesis imperfecta, type vi and corneal neovascularization. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA10.

UniProtKB/Swiss-Prot for SERPINF1 Gene

  • Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Gene Wiki entry for SERPINF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINF1 Gene

Genomics for SERPINF1 Gene

Genomic Location for SERPINF1 Gene

1,761,959 bp from pter
1,777,574 bp from pter
15,616 bases
Plus strand

Genomic View for SERPINF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINF1 Gene

Regulatory Elements for SERPINF1 Gene

Proteins for SERPINF1 Gene

  • Protein details for SERPINF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pigment epithelium-derived factor
    Protein Accession:
    Secondary Accessions:
    • F1T092
    • Q13236
    • Q2TU83
    • Q96CT1
    • Q96R01
    • Q9BWA4

    Protein attributes for SERPINF1 Gene

    418 amino acids
    Molecular mass:
    46312 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA84914.1; Type=Frameshift; Positions=356; Evidence={ECO:0000305}; Sequence=AAA93524.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SERPINF1 Gene

neXtProt entry for SERPINF1 Gene

Proteomics data for SERPINF1 Gene at MOPED

Post-translational modifications for SERPINF1 Gene

  • N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn285

No data available for DME Specific Peptides for SERPINF1 Gene

Domains for SERPINF1 Gene

Gene Families for SERPINF1 Gene

  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINF1 Gene



  • The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity:
    • P36955
  • Belongs to the serpin family.:
    • P36955
genes like me logo Genes that share domains with SERPINF1: view

Function for SERPINF1 Gene

Molecular function for SERPINF1 Gene

UniProtKB/Swiss-Prot Function: Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Gene Ontology (GO) - Molecular Function for SERPINF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity TAS 8473338
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SERPINF1: view
genes like me logo Genes that share phenotypes with SERPINF1: view

miRNA for SERPINF1 Gene

miRTarBase miRNAs that target SERPINF1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SERPINF1 Gene

Localization for SERPINF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINF1 Gene

Secreted. Melanosome. Note=Enriched in stage I melanosomes.

Subcellular locations from

Jensen Localization Image for SERPINF1 Gene COMPARTMENTS Subcellular localization image for SERPINF1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
cytosol 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SERPINF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 12737624
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IDA 20551380
GO:0030424 axon --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
genes like me logo Genes that share ontologies with SERPINF1: view

Pathways for SERPINF1 Gene

genes like me logo Genes that share pathways with SERPINF1: view

Pathways by source for SERPINF1 Gene

2 Qiagen pathways for SERPINF1 Gene

Gene Ontology (GO) - Biological Process for SERPINF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0007275 multicellular organismal development TAS 8473338
GO:0007568 aging IEA --
GO:0007614 short-term memory IEA --
GO:0008283 cell proliferation TAS 8473338
genes like me logo Genes that share ontologies with SERPINF1: view

Compounds for SERPINF1 Gene

(28) Novoseek inferred chemical compound relationships for SERPINF1 Gene

Compound -log(P) Hits PubMed IDs
vegf 80.1 283
matrigel 46.7 2
verteporfin 44.8 1
serine 35.9 26
olmesartan 31.2 2
genes like me logo Genes that share compounds with SERPINF1: view

Transcripts for SERPINF1 Gene


Unigene Clusters for SERPINF1 Gene

Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6: - - - -
SP9: - -

Relevant External Links for SERPINF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERPINF1 Gene

mRNA expression in normal human tissues for SERPINF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERPINF1 Gene

SOURCE GeneReport for Unigene cluster for SERPINF1 Gene Hs.532768

mRNA Expression by UniProt/SwissProt for SERPINF1 Gene

Tissue specificity: Retinal pigment epithelial cells and blood plasma.
genes like me logo Genes that share expressions with SERPINF1: view

Orthologs for SERPINF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERPINF1 36
  • 99.04 (n)
  • 99.28 (a)
  • 99 (a)
(Bos Taurus)
Mammalia SERPINF1 36
  • 87.07 (n)
  • 87.95 (a)
  • 88 (a)
(Canis familiaris)
Mammalia SERPINF1 36
  • 87.46 (n)
  • 91.24 (a)
  • 90 (a)
(Mus musculus)
Mammalia Serpinf1 36
  • 84.5 (n)
  • 87.17 (a)
Serpinf1 16
Serpinf1 37
  • 86 (a)
(Monodelphis domestica)
Mammalia SERPINF1 37
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia SERPINF1 37
  • 77 (a)
(Rattus norvegicus)
Mammalia Serpinf1 36
  • 83.78 (n)
  • 84.02 (a)
(Gallus gallus)
Aves SERPINF1 36
  • 66.75 (n)
  • 63.29 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia SERPINF1 37
  • 58 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4797 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76294 36
serpinf1 36
  • 61.07 (n)
  • 56.79 (a)
(Danio rerio)
Actinopterygii serpinf1 36
  • 49.96 (n)
  • 41.6 (a)
serpinf1 37
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spn27A 37
  • 17 (a)
Spn5 37
  • 20 (a)
Spn88Eb 37
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 18 (a)
CSA.10120 37
  • 21 (a)
Species with no ortholog for SERPINF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINF1 Gene

Gene Tree for SERPINF1 (if available)
Gene Tree for SERPINF1 (if available)

Paralogs for SERPINF1 Gene

Selected SIMAP similar genes for SERPINF1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SERPINF1: view

Variants for SERPINF1 Gene

Sequence variations from dbSNP and Humsavar for SERPINF1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs6828 -- 1,776,708(+) AGTTA(C/G/T)GAAGG synonymous-codon, stop-gained, reference
rs9809 -- 1,777,378(+) TCTTC(A/G)TACTG missense, reference
rs1136287 - 1,769,982(+) CAGCA(C/T)GAGCC reference, missense
rs1804145 - 1,771,140(+) TGCCC(A/C/G)CCAGA missense, reference
rs1804146 -- 1,777,470(+) CAATA(C/T)CCTAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SERPINF1 Gene

Variant ID Type Subtype PubMed ID
nsv907511 CNV Loss 21882294
nsv9490 CNV Loss 18304495
dgv3033n71 CNV Loss 21882294
nsv833335 CNV Gain+Loss 17160897
nsv1946 CNV Insertion 18451855
nsv907521 CNV Gain 21882294

Relevant External Links for SERPINF1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

Disorders for SERPINF1 Gene

(1) OMIM Diseases for SERPINF1 Gene (172860)


  • Osteogenesis imperfecta 6 (OI6) [MIM:613982]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI6 is a severe, autosomal recessive form compatible with OI type III in the Sillence classification. {ECO:0000269 PubMed:21353196}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for SERPINF1 Gene

(61) Novoseek inferred disease relationships for SERPINF1 Gene

Disease -log(P) Hits PubMed IDs
proliferative diabetic retinopathy 81 20
choroidal neovascularization 76.1 19
diabetic retinopathy 72.8 49
neovascularization 71.5 25
retinal neovascularization 70.4 11

Relevant External Links for SERPINF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SERPINF1: view

Publications for SERPINF1 Gene

  1. Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family. (PMID: 8434014) Steele F.R. … Tombran-Tink J. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23
  2. Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop. (PMID: 7592790) Becerra S.P. … Notario V. (J. Biol. Chem. 1995) 3 4 23
  3. Overexpression of fetal human pigment epithelium-derived factor in Escherichia coli. A functionally active neurotrophic factor. (PMID: 8226833) Becerra S.P. … Chader G.J. (J. Biol. Chem. 1993) 3 4 23
  4. Four polymorphic variations in the PEDF gene identified during the mutation screening of patients with Leber congenital amaurosis. (PMID: 10398730) Koenekoop R. … Tombran-Tink J. (Mol. Vis. 1999) 3 4 23
  5. Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization. (PMID: 12737624) Petersen S.V. … Enghild J.J. (Biochem. J. 2003) 3 4 23

Products for SERPINF1 Gene

Sources for SERPINF1 Gene

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