SERPINE3 Gene
protein-coding GIFtS: 33
GCID: GC13P051917
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serpin peptidase inhibitor, clade E (nexin, plasminogen...
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Aliases
for SERPINE3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator InhibitorType 1), Member 31 2 | | Nexin-Related Serine Protease Inhibitor2 | | Serpin E32 |
Export aliases for SERPINE3 gene to outside databasesPrevious GC identifers: GC13P050814 GC13P051909 GC13P032704 |
Summaries
for SERPINE3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SERP3_HUMAN, A8MV23Function: Probable serine protease inhibitor (By similarity)
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Genomic Views
for SERPINE3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SERPINE3 gene promoter:
RP58 GCNF AP-4 POU3F2 AREB6 PPAR-gamma1 GCNF-1 PPAR-gamma2 GCNF-2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for SERPINE3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINE3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.3 HGNC cytogenetic band: 13q14.3SERPINE3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P051917: view genomic region
(about GC identifiers)
Start:
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51,909,909 bp from pter |
End:
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51,938,871 bp from pter |
Size:
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28,963 bases |
Orientation:
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plus strand |
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Proteins
for SERPINE3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SERP3_HUMAN, A8MV23 (See
protein sequence)Recommended Name: Serpin E3 precursor Size: 424 amino acids; 46963 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B1V8P3Alternative splicing: 2 isoforms: A8MV23-1 A8MV23-2 Explore the universe of human proteins at neXtProt for SERPINE3: NX_A8MV23
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A8MV23
SERPINE3 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001094790.1
ENSEMBL proteins: ENSP00000430755 ENSP00000427824 ENSP00000428316 ENSP00000441468
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005576 | extracellular region |
IEA | -- |
SERPINE3 for ontologies About GeneDecksing
SERPINE3 Antibody Products:
Assay Products for SERPINE3: |
Protein
Domains /
Families
for SERPINE3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SERPINE3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A8MV23ProtoNet protein and cluster: A8MV23 UniProtKB/Swiss-Prot: SERP3_HUMAN, A8MV23Similarity: Belongs to the serpin family |
Function
for SERPINE3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SERP3_HUMAN, A8MV23Function: Probable serine protease inhibitor (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINE3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINE3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SERPINE3 (NM_001101320) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERPINE3 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SERPINE3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity |
IBA | -- |
SERPINE3 for ontologies About GeneDecksing
|
Pathways & Interactions
for SERPINE3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERPINE3
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010951 | negative regulation of endopeptidase activity |
IBA | -- | | GO:0030162 | regulation of proteolysis |
IBA | -- |
SERPINE3 for ontologies About GeneDecksing
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Drugs & Compounds
for SERPINE3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SERPINE3
Search CenterWatch for drugs/clinical trials and news about SERPINE3 / SERP3
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Transcripts
for SERPINE3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SERPINE3 gene: NM_001101320.1 Unigene Cluster for SERPINE3: Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 Hs.685891 [show with all ESTs]Unigene Representative Sequence: NM_0011013204 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000524365 ENST00000419898 ENST00000521255(uc001vfh.2) ENST00000400389(uc010tgp.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINE3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINE3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SERPINE3 (NM_001101320) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERPINE3 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SERPINE3 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINE3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SERPINE3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINE3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINE3 |
Additional cDNA sequence: AM402969.1 2 DOTS entries: DT.99981820 DT.100773965
GeneLoc Exon Structure
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Expression
for SERPINE3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SERPINE3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTTACCT
About this image
SOURCE GeneReport for Unigene cluster: Hs.685891
SABiosciences Custom PCR Arrays for SERPINE3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINE3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SERPINE3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINE3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINE3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE3 |
Orthologs
for SERPINE3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for SERPINE3 gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for SERPINE3 (if available)
TreeFam Gene Tree for SERPINE3 (if available) |
Paralogs
for SERPINE3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SERPINE3 gene
- SERPINB72 SERPINB12 SERPINI12 SERPINB52 SERPINB122 SERPINI22 SERPINB22 SERPINB102
- SERPINB32 SERPINB42 SERPINE22 SERPINB62 SERPINC12 SERPINB92 SERPINE12 SERPINB132
- SERPINB82
11 SIMAP similar genes for SERPINE3 using alignment to 2 protein entries: SERP3_HUMAN (see all proteins):DKFZp686D06190 AT3 DKFZp686O07189 SERPINB12 SERPINI1 SERPINI2
SERPINE2 SERPINE1 SERPINB1 SERPINB11 SERPINB3
SERPINE3 for paralogs About GeneDecksing
|
Genomic Variants
for SERPINE3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SERPINE3 (51909909 - 51938871 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SERPINE3: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for SERPINE3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SERPINE3 for disorders About GeneDecksing
1  disease for SERPINE3: About MalaCardsfamilial encephalopathy with neuroserpin inclusion bodies
Export disorders for SERPINE3 gene to outside databases
|
Publications
for SERPINE3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SERPINE3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SERPINE3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for SERPINE3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SERPINE3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SERPINE3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SERPINE3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SERPINE3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SERPINE3 gene:
Search GeneIP for patents involving SERPINE3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SERPINE3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SERPINE3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINE3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINE3 | | | OriGene Protein Over-expression Lysate for SERPINE3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SERPINE3 | | OriGene 3'-UTR Clone for SERPINE3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINE3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINE3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SERPINE3 | | OriGene Custom Protein Services for SERPINE3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERPINE3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINE3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINE3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINE3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINE3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINE3 |
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 | | | SERPINE3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE3 |
|  |  |  | | | | Search ThermoFisher Antibodies for SERPINE3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SERPINE3 |
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