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Aliases for SERPINE3 Gene

Aliases for SERPINE3 Gene

  • Serpin Family E Member 3 2 3 5
  • Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 3 2

External Ids for SERPINE3 Gene

Previous GeneCards Identifiers for SERPINE3 Gene

  • GC13P050814
  • GC13P051909
  • GC13P032704
  • GC13P051917

Summaries for SERPINE3 Gene

GeneCards Summary for SERPINE3 Gene

SERPINE3 (Serpin Family E Member 3) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINE2.

UniProtKB/Swiss-Prot for SERPINE3 Gene

  • Probable serine protease inhibitor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINE3 Gene

Genomics for SERPINE3 Gene

Regulatory Elements for SERPINE3 Gene

Enhancers for SERPINE3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F051618 1 Ensembl ENCODE 23.3 +284.2 284228 2.8 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ALG11 RPS4XP16 SERPINE3 UTP14C ATP5F1P1 PIR45932
GH13F050356 1.1 Ensembl ENCODE 22.7 -977.8 -977785 2.5 PKNOX1 ATF1 FEZF1 ZNF2 FOS SP3 ZHX2 REST TSHZ1 ZNF264 SERPINE3 TRIM13 KCNRG EBPL RPL34P26 GC13M050344
GH13F051450 0.5 ENCODE 22 +117.3 117285 5.6 PKNOX1 MLX ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 ZNF263 SERPINE3 ALG11 CCDC70 LOC103191607 RPS4XP16 DHRS12 ENSG00000231856 INTS6-AS1
GH13F051315 1 Ensembl ENCODE 21.2 -20.1 -20067 1.3 GFI1B MAX REST ZNF670 ZIC2 GLIS1 ZNF701 ZNF548 ZNF280C ALG11 SERPINE3 FAM124A GC13P051260
GH13F051635 1 Ensembl ENCODE 12.9 +301.3 301329 4.2 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ALG11 SERPINE3 RPS4XP16 WDFY2 DHRS12 ATP5F1P1 PIR45932
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SERPINE3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERPINE3 Gene

Chromosome:
13
Start:
51,335,773 bp from pter
End:
51,365,454 bp from pter
Size:
29,682 bases
Orientation:
Plus strand

Genomic View for SERPINE3 Gene

Genes around SERPINE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINE3 Gene

Proteins for SERPINE3 Gene

  • Protein details for SERPINE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MV23-SERP3_HUMAN
    Recommended name:
    Serpin E3
    Protein Accession:
    A8MV23
    Secondary Accessions:
    • B1V8P3

    Protein attributes for SERPINE3 Gene

    Size:
    424 amino acids
    Molecular mass:
    46963 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINE3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINE3 Gene

Post-translational modifications for SERPINE3 Gene

  • Glycosylation at Asn 46
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINE3 Gene

No data available for DME Specific Peptides for SERPINE3 Gene

Domains & Families for SERPINE3 Gene

Gene Families for SERPINE3 Gene

Protein Domains for SERPINE3 Gene

Suggested Antigen Peptide Sequences for SERPINE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MV23

UniProtKB/Swiss-Prot:

SERP3_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINE3: view

Function for SERPINE3 Gene

Molecular function for SERPINE3 Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease inhibitor.

Gene Ontology (GO) - Molecular Function for SERPINE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINE3: view

Phenotypes for SERPINE3 Gene

GenomeRNAi human phenotypes for SERPINE3:
genes like me logo Genes that share phenotypes with SERPINE3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINE3 Gene

Localization for SERPINE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINE3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINE3 Gene COMPARTMENTS Subcellular localization image for SERPINE3 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for SERPINE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IBA --
genes like me logo Genes that share ontologies with SERPINE3: view

Pathways & Interactions for SERPINE3 Gene

SuperPathways for SERPINE3 Gene

No Data Available

Interacting Proteins for SERPINE3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000428316%0d%0a9606.ENSP00000053867%0d%0a9606.ENSP00000342070%0d%0a
Selected Interacting proteins: ENSP00000428316 A8MV23-SERP3_HUMAN for SERPINE3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SERPINE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SERPINE3: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINE3 Gene

Transcripts for SERPINE3 Gene

mRNA/cDNA for SERPINE3 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINE3 Gene

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINE3 Gene

No ASD Table

Relevant External Links for SERPINE3 Gene

GeneLoc Exon Structure for
SERPINE3
ECgene alternative splicing isoforms for
SERPINE3

Expression for SERPINE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERPINE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERPINE3 Gene

This gene is overexpressed in Thyroid (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINE3 Gene



Protein tissue co-expression partners for SERPINE3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERPINE3 Gene:

SERPINE3

SOURCE GeneReport for Unigene cluster for SERPINE3 Gene:

Hs.685891
genes like me logo Genes that share expression patterns with SERPINE3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SERPINE3 Gene

Orthologs for SERPINE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINE3 34 35
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia SERPINE3 34 35
  • 79.62 (n)
rat
(Rattus norvegicus)
Mammalia Serpine3 34
  • 76.66 (n)
mouse
(Mus musculus)
Mammalia Serpine3 34 16 35
  • 74.28 (n)
dog
(Canis familiaris)
Mammalia SERPINE3 34 35
  • 72.76 (n)
oppossum
(Monodelphis domestica)
Mammalia SERPINE3 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERPINE3 34 35
  • 61.37 (n)
lizard
(Anolis carolinensis)
Reptilia SERPINE3 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serpine3 34
  • 61.04 (n)
zebrafish
(Danio rerio)
Actinopterygii serpine3 34 35
  • 54.35 (n)
Species where no ortholog for SERPINE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINE3 Gene

ENSEMBL:
Gene Tree for SERPINE3 (if available)
TreeFam:
Gene Tree for SERPINE3 (if available)

Paralogs for SERPINE3 Gene

Variants for SERPINE3 Gene

Sequence variations from dbSNP and Humsavar for SERPINE3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10454626 -- 51,357,017(+) TTTGT(A/G)AAGTT intron-variant
rs10563020 -- 51,356,783(+) AAACC(-/T)TTTTT intron-variant
rs10688052 -- 51,358,083(+) CCATA(-/CATA)GCCTA intron-variant
rs111371936 -- 51,354,641(+) TTTCT(C/G)AGGTA intron-variant
rs111664923 -- 51,345,552(+) ACTGC(A/G)TCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINE3 Gene

Variant ID Type Subtype PubMed ID
dgv1000e59 CNV tandem duplication 20981092
esv3424137 CNV duplication 20981092
nsv1041 CNV insertion 18451855
nsv1116727 CNV tandem duplication 24896259
nsv561618 CNV loss 21841781
nsv832611 CNV loss 17160897

Variation tolerance for SERPINE3 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINE3 Gene

Disorders for SERPINE3 Gene

Relevant External Links for SERPINE3

Genetic Association Database (GAD)
SERPINE3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINE3

No disorders were found for SERPINE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINE3 Gene

Publications for SERPINE3 Gene

  1. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3 64
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 64
  3. A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels. (PMID: 25240745) LA^pez S. … Soria J.M. (Mitochondrion 2014) 3 64

Products for SERPINE3 Gene

Sources for SERPINE3 Gene

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