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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINE3 Gene

protein-coding   GIFtS: 35
GCID: GC13P051917

Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen...

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator
Inhibitor Type 1), Member 31 2
Nexin-Related Serine Protease Inhibitor2
Serpin E32

External Ids:    HGNC: 247741   Entrez Gene: 6471742   Ensembl: ENSG000002533097   UniProtKB: A8MV233   

Export aliases for SERPINE3 gene to outside databases

Previous GC identifers: GC13P050814 GC13P051909 GC13P032704


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SERPINE3 Gene: 
SERPINE3 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3) is a protein-coding gene. Diseases associated with SERPINE3 include familial encephalopathy with neuroserpin inclusion bodies. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: SERP3_HUMAN, A8MV23
Function: Probable serine protease inhibitor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINE3 gene promoter:
         RP58   GCNF   AP-4   POU3F2   AREB6   PPAR-gamma1   GCNF-1   PPAR-gamma2   GCNF-2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SERPINE3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.3   HGNC cytogenetic band: 13q14.3

SERPINE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINE3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P051917:  view genomic region     (about GC identifiers)

Start:
51,909,909 bp from pter      End:
51,938,871 bp from pter
Size:
28,963 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SERP3_HUMAN, A8MV23 (See protein sequence)
Recommended Name: Serpin E3 precursor  
Size: 424 amino acids; 46963 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B1V8P3
Alternative splicing: 2 isoforms:  A8MV23-1   A8MV23-2   

Explore the universe of human proteins at neXtProt for SERPINE3: NX_A8MV23

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A8MV23

  • SERPINE3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001094790.1  
    ENSEMBL proteins: 
     ENSP00000430755   ENSP00000427824   ENSP00000428316   ENSP00000441468  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    SERPINE3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry A8MV23

    ProtoNet protein and cluster: A8MV23

    UniProtKB/Swiss-Prot: SERP3_HUMAN, A8MV23
    Similarity: Belongs to the serpin family


    SERPINE3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SERP3_HUMAN, A8MV23
    Function: Probable serine protease inhibitor (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--
         
    SERPINE3 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERPINE3

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--

    SERPINE3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about SERPINE3 / SERP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for SERPINE3 gene: 
    NM_001101320.1  

    Unigene Cluster for SERPINE3:

    Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
    Hs.685891  [show with all ESTs]
    Unigene Representative Sequence: NM_001101320
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524365 ENST00000419898 ENST00000521255(uc001vfh.2) ENST00000400389(uc010tgp.2)

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    Additional mRNA sequence: AM402969.1 

    2 DOTS entries:

    DT.100773965  DT.99981820 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINE3 expression in normal human tissues (normalized intensities)      SERPINE3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTTACCT
    SERPINE3 Expression
    About this image


    SERPINE3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
     
     Eye (Sensory Organs)
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   

    SOURCE GeneReport for Unigene cluster: Hs.685891
        SABiosciences Custom PCR Arrays for SERPINE3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SERPINE3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpine31 , 5 serpin peptidase inhibitor, clade E (nexin, plasminogen more1, 5 74.79(n)1
    67.51(a)1
      14 (33.23 cM)5
    3194331  NM_001199945.11  NP_001186874.11 
     626636675 
    chicken
    (Gallus gallus)
    Aves SERPINE31 serpin peptidase inhibitor, clade E (nexin, plasminogen more 61.27(n)
    52.66(a)
      418875  XM_417070.3  XP_417070.3 
    lizard
    (Anolis carolinensis)
    Reptilia SERPINE36
    Uncharacterized protein
    45(a)
    1 ↔ 1
    1(139981709-139997551)
    zebrafish
    (Danio rerio)
    Actinopterygii serpine31 serpin peptidase inhibitor, clade E (nexin, plasminogen more 54.4(n)
    44.91(a)
      556612  NM_001123237.1  NP_001116709.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spn16
    Spn26
    (see all 17)
    Serine protease inhibitor 2
    (see all 17)
    26(a)
    23(a)
    (see all 17)
    many ↔ many
    many ↔ many
    (see all 17)
    2R(2770786-2772378)
    2L(8240414-8241800)
    worm
    (Caenorhabditis elegans)
    Secernentea srp-26
    srp-76
    (see all 6)
    Protein SRP-7, isoform d
    (see all 6)
    25(a)
    23(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    V(762734-764657)
    V(8179131-8183442)


    ENSEMBL Gene Tree for SERPINE3 (if available)
    TreeFam Gene Tree for SERPINE3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINE3 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB32  SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINB112  
    SERPINB132  SERPINB82  
    11 SIMAP similar genes for SERPINE3 using alignment to 2 protein entries:     SERP3_HUMAN (see all proteins):
    DKFZp686D06190    AT3    DKFZp686O07189    SERPINB12    SERPINI1    SERPINI2
    SERPINE2    SERPINE1    SERPINB1    SERPINB11    SERPINB3

    SERPINE3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/347 SNPs in SERPINE3 are shown (see all 347)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs619569121,2
    C,F--51913202(+) ACATGG/ATCTCT 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1415739731,2
    --51913280(+) GTTACA/GTATAT 1 -- us2k10--------
    rs1509153631,2
    --51913334(+) ACCCTA/GCTCCG 1 -- us2k10--------
    rs1819231151,2
    --51913510(+) TCAGTA/GGAATT 1 -- us2k10--------
    rs95356461,2
    C,F,H--51913708(+) TGGACC/TGAGTG 1 -- us2k111Minor allele frequency- T:0.11NS EA NA 806
    rs1396767831,2
    --51913766(+) GCTGTC/TTTGTG 1 -- us2k10--------
    rs125861101,2
    C,F,H--51913860(+) ACGTGC/TAACAG 1 -- us2k19Minor allele frequency- T:0.03NS EA NA WA 664
    rs1127055151,2
    C,F--51913887(+) GAGTAC/TGTGGC 1 -- us2k12Minor allele frequency- T:0.08NA EA 122
    rs1858927371,2
    C--51913899(+) CATTCA/GAGGTG 1 -- us2k10--------
    rs1486008461,2
    C--51914045(+) CTGGG-/ACACACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SERPINE3 (51909909 - 51938871 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SERPINE3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1041CNV Insertion18451855
    nsv832611CNV Loss17160897
    esv259735OTHER Complex20981092
    esv259575OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SERPINE3:    About MalaCards
    familial encephalopathy with neuroserpin inclusion bodies    


    SERPINE3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SERPINE3

    Export disorders for SERPINE3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINE3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SERPINE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    2. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 647174 HGNC: 24774 Ensembl:ENSG00000253309 euGenes: HUgn647174 ECgene: SERPINE3
    H-InvDB: SERPINE3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINE3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERPINE3 gene:
    Search GeneIP for patents involving SERPINE3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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