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Aliases for SERPINE3 Gene

Aliases for SERPINE3 Gene

  • Serpin Family E Member 3 2 3 5
  • Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 3 2

External Ids for SERPINE3 Gene

Previous GeneCards Identifiers for SERPINE3 Gene

  • GC13P050814
  • GC13P051909
  • GC13P032704
  • GC13P051917

Summaries for SERPINE3 Gene

GeneCards Summary for SERPINE3 Gene

SERPINE3 (Serpin Family E Member 3) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINE2.

UniProtKB/Swiss-Prot for SERPINE3 Gene

  • Probable serine protease inhibitor.

Additional gene information for SERPINE3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINE3 Gene

Genomics for SERPINE3 Gene

Regulatory Elements for SERPINE3 Gene

Enhancers for SERPINE3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H051522 1.3 Ensembl ENCODE 12.5 +188.8 188778 3.7 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 GTF3C2 SLC30A9 ATF7 ALG11 SERPINE3 UTP14C RPS4XP16 INTS6 WDFY2 MIR4703 SNRPGP11
GH13H050526 1.5 FANTOM5 Ensembl ENCODE 10.7 -807.0 -807047 5 PKNOX1 INSM2 FEZF1 ZBTB40 RAD21 YY1 ZNF121 ZNF366 ZSCAN5C SCRT2 RPL34P26 SERPINE3 KCNRG RNASEH2B-AS1 RNASEH2B DLEU7 EBPL GC13P050529 GC13P050590
GH13H051450 1.4 ENCODE dbSUPER 10.8 +117.3 117285 5.6 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 MRPS31P5 CCDC70 LINC02333 SERPINE3 DHRS12 ENSG00000231856 ALG11 RPS4XP16 INTS6-AS1
GH13H050356 1.2 Ensembl ENCODE 11.6 -977.8 -977785 2.5 PKNOX1 ATF1 FEZF1 ZNF2 YY1 FOS ATF7 SP3 REST TSHZ1 SERPINE3 SETDB2 EBPL RPL34P26 GC13M050344
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERPINE3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SERPINE3 Gene

Genomic Locations for SERPINE3 Gene
29,682 bases
Plus strand

Genomic View for SERPINE3 Gene

Genes around SERPINE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINE3 Gene

Proteins for SERPINE3 Gene

  • Protein details for SERPINE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serpin E3
    Protein Accession:
    Secondary Accessions:
    • B1V8P3

    Protein attributes for SERPINE3 Gene

    424 amino acids
    Molecular mass:
    46963 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINE3 Gene


neXtProt entry for SERPINE3 Gene

Post-translational modifications for SERPINE3 Gene

  • Glycosylation at isoforms=246
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINE3 Gene

No data available for DME Specific Peptides for SERPINE3 Gene

Domains & Families for SERPINE3 Gene

Gene Families for SERPINE3 Gene

Protein Domains for SERPINE3 Gene

Suggested Antigen Peptide Sequences for SERPINE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serpin family.
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINE3: view

Function for SERPINE3 Gene

Molecular function for SERPINE3 Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease inhibitor.

Phenotypes From GWAS Catalog for SERPINE3 Gene

Gene Ontology (GO) - Molecular Function for SERPINE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINE3: view

Phenotypes for SERPINE3 Gene

GenomeRNAi human phenotypes for SERPINE3:
genes like me logo Genes that share phenotypes with SERPINE3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINE3 Gene

Localization for SERPINE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINE3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINE3 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for SERPINE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with SERPINE3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINE3 Gene

Pathways & Interactions for SERPINE3 Gene

SuperPathways for SERPINE3 Gene

No Data Available

Interacting Proteins for SERPINE3 Gene

Gene Ontology (GO) - Biological Process for SERPINE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SERPINE3: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINE3 Gene

Drugs & Compounds for SERPINE3 Gene

No Compound Related Data Available

Transcripts for SERPINE3 Gene


(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINE3 Gene

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINE3 Gene

No ASD Table

Relevant External Links for SERPINE3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERPINE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERPINE3 Gene

This gene is overexpressed in Thyroid (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINE3 Gene

Protein tissue co-expression partners for SERPINE3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERPINE3 Gene:


SOURCE GeneReport for Unigene cluster for SERPINE3 Gene:

genes like me logo Genes that share expression patterns with SERPINE3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINE3 Gene

Orthologs for SERPINE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINE3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERPINE3 33 34
  • 99.29 (n)
(Bos Taurus)
Mammalia SERPINE3 33 34
  • 79.62 (n)
(Rattus norvegicus)
Mammalia Serpine3 33
  • 76.66 (n)
(Mus musculus)
Mammalia Serpine3 33 16 34
  • 74.28 (n)
(Canis familiaris)
Mammalia SERPINE3 33 34
  • 72.76 (n)
(Monodelphis domestica)
Mammalia SERPINE3 34
  • 62 (a)
(Gallus gallus)
Aves SERPINE3 33 34
  • 61.37 (n)
(Anolis carolinensis)
Reptilia SERPINE3 34
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia serpine3 33
  • 61.04 (n)
(Danio rerio)
Actinopterygii serpine3 33 34
  • 54.35 (n)
Species where no ortholog for SERPINE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINE3 Gene

Gene Tree for SERPINE3 (if available)
Gene Tree for SERPINE3 (if available)

Paralogs for SERPINE3 Gene

(11) SIMAP similar genes for SERPINE3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SERPINE3: view

Variants for SERPINE3 Gene

Sequence variations from dbSNP and Humsavar for SERPINE3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000428063 -- 51,335,631(+) TTCCC(A/G/T)CACAG utr-variant-5-prime
rs1000526505 -- 51,359,654(+) TGATA(A/G)GGGGT intron-variant
rs1000643609 -- 51,341,645(+) AATAG(A/G)TTTCA intron-variant, utr-variant-5-prime
rs1000686907 -- 51,352,472(+) ATAGG(-/T)TTTTT intron-variant
rs1001172741 -- 51,353,532(+) TCAGG(A/C)ATTGG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SERPINE3 Gene

Variant ID Type Subtype PubMed ID
nsv832611 CNV loss 17160897
nsv561618 CNV loss 21841781
nsv1116727 CNV tandem duplication 24896259
nsv1041 CNV insertion 18451855
esv3424137 CNV duplication 20981092
dgv1000e59 CNV tandem duplication 20981092

Variation tolerance for SERPINE3 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINE3 Gene

Disorders for SERPINE3 Gene

Relevant External Links for SERPINE3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SERPINE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINE3 Gene

Publications for SERPINE3 Gene

  1. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3 60
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 60
  3. A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels. (PMID: 25240745) López S … Soria JM (Mitochondrion 2014) 3 60

Products for SERPINE3 Gene

Sources for SERPINE3 Gene

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