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Aliases for SERPINE2 Gene

Aliases for SERPINE2 Gene

  • Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 2 2 3
  • PI7 3 4 6
  • Peptidase Inhibitor 7 3 4
  • Protease Nexin I 3 4
  • Serpin E2 3 4
  • PI-7 3 4
  • PN-1 3 4
  • GDN 3 4
  • PN1 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 2 2
  • Glial-Derived Neurite Promoting Factor 3
  • Glial-Derived Nexin 1 2
  • Glia-Derived Nexin 3
  • Protease Nexin 1 4
  • GDNPF 3
  • PN1, 6
  • PNI 3

External Ids for SERPINE2 Gene

Previous Symbols for SERPINE2 Gene

  • PI7

Summaries for SERPINE2 Gene

Entrez Gene Summary for SERPINE2 Gene

  • This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for SERPINE2 Gene

SERPINE2 (Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 2) is a Protein Coding gene. Among its related pathways are Hemostasis and Translation Insulin regulation of translation. GO annotations related to this gene include receptor binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINE2 Gene

  • Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin

Gene Wiki entry for SERPINE2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINE2 Gene

Genomics for SERPINE2 Gene

Genomic Location for SERPINE2 Gene

Start:
223,975,048 bp from pter
End:
224,039,319 bp from pter
Size:
64,272 bases
Orientation:
Minus strand

Genomic View for SERPINE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINE2 Gene

Regulatory Elements for SERPINE2 Gene

Proteins for SERPINE2 Gene

  • Protein details for SERPINE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07093-GDN_HUMAN
    Recommended name:
    Glia-derived nexin
    Protein Accession:
    P07093
    Secondary Accessions:
    • B2R6A4
    • B4DIF2
    • Q53S15
    • Q5D0C4

    Protein attributes for SERPINE2 Gene

    Size:
    398 amino acids
    Molecular mass:
    44002 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SERPINE2 Gene

    Alternative splice isoforms for SERPINE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINE2 Gene

Proteomics data for SERPINE2 Gene at MOPED

Post-translational modifications for SERPINE2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn118 and Asn159

Other Protein References for SERPINE2 Gene

No data available for DME Specific Peptides for SERPINE2 Gene

Domains for SERPINE2 Gene

Gene Families for SERPINE2 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINE2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

GDN_HUMAN
Family:
  • Belongs to the serpin family.:
    • P07093
genes like me logo Genes that share domains with SERPINE2: view

Function for SERPINE2 Gene

Molecular function for SERPINE2 Gene

UniProtKB/Swiss-Prot Function: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin

Gene Ontology (GO) - Molecular Function for SERPINE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IMP 19855083
GO:0005102 receptor binding IPI 17379830
GO:0005515 protein binding IPI 19911255
GO:0005539 glycosaminoglycan binding IDA 19855083
GO:0008201 heparin binding IDA 1939253
genes like me logo Genes that share ontologies with SERPINE2: view
genes like me logo Genes that share phenotypes with SERPINE2: view

Animal Models for SERPINE2 Gene

MGI Knock Outs for SERPINE2:

miRNA for SERPINE2 Gene

miRTarBase miRNAs that target SERPINE2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SERPINE2 Gene

Localization for SERPINE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINE2 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINE2 Gene COMPARTMENTS Subcellular localization image for SERPINE2 gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 4
cytoskeleton 2
endosome 2
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SERPINE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005829 cytosol IDA 19855083
GO:0031012 extracellular matrix IDA 3279057
GO:0031091 platelet alpha granule IMP 19855083
genes like me logo Genes that share ontologies with SERPINE2: view

Pathways for SERPINE2 Gene

genes like me logo Genes that share pathways with SERPINE2: view

Pathways by source for SERPINE2 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for SERPINE2 Gene
2 Reactome pathways for SERPINE2 Gene

Gene Ontology (GO) - Biological Process for SERPINE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0009611 response to wounding --
GO:0010466 negative regulation of peptidase activity --
GO:0010544 negative regulation of platelet activation --
genes like me logo Genes that share ontologies with SERPINE2: view

Compounds for SERPINE2 Gene

(10) Novoseek inferred chemical compound relationships for SERPINE2 Gene

Compound -log(P) Hits PubMed IDs
serine 74.2 40
heparin 43.9 21
cycloheximide 17.3 2
glycosaminoglycan 16.2 2
actinomycin d 12.9 1
genes like me logo Genes that share compounds with SERPINE2: view

Transcripts for SERPINE2 Gene

Unigene Clusters for SERPINE2 Gene

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINE2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - -
SP2: - - - - - - - - - - -
SP3: -
SP4: - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - - - -
SP10: - - - - - - - - -

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for SERPINE2 Gene

GeneLoc Exon Structure for
SERPINE2
ECgene alternative splicing isoforms for
SERPINE2

Expression for SERPINE2 Gene

mRNA expression in normal human tissues for SERPINE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINE2 Gene

SOURCE GeneReport for Unigene cluster for SERPINE2 Gene Hs.38449

genes like me logo Genes that share expressions with SERPINE2: view

Orthologs for SERPINE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINE2 36
  • 99.43 (n)
  • 99.51 (a)
SERPINE2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINE2 36
  • 88.16 (n)
  • 91.69 (a)
SERPINE2 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINE2 36
  • 86.6 (n)
  • 91.32 (a)
SERPINE2 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpine2 36
  • 84.21 (n)
  • 85.39 (a)
Serpine2 16
Serpine2 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERPINE2 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINE2 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpine2 36
  • 83.29 (n)
  • 84.38 (a)
chicken
(Gallus gallus)
Aves SERPINE2 36
  • 76.46 (n)
  • 79.49 (a)
SERPINE2 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERPINE2 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12045 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76024 36
serpine2 36
  • 68.72 (n)
  • 72.75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6921 36
zebrafish
(Danio rerio)
Actinopterygii serpine2 36
  • 59.15 (n)
  • 54.66 (a)
serpine2 37
  • 53 (a)
OneToOne
zgc55929 36
fruit fly
(Drosophila melanogaster)
Insecta nec 38
  • 30 (a)
Species with no ortholog for SERPINE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINE2 Gene

ENSEMBL:
Gene Tree for SERPINE2 (if available)
TreeFam:
Gene Tree for SERPINE2 (if available)

Paralogs for SERPINE2 Gene

Pseudogenes.org Pseudogenes for SERPINE2 Gene

genes like me logo Genes that share paralogs with SERPINE2: view

Variants for SERPINE2 Gene

Sequence variations from dbSNP and Humsavar for SERPINE2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs12138 -- 224,001,670(-) CAGCT(A/C/T)GCCAT synonymous-codon, reference, nc-transcript-variant
rs12436 -- 224,001,859(-) GTGAC(G/T)CTGCC reference, synonymous-codon, nc-transcript-variant
rs12457 -- 223,998,125(-) AAAAA(C/T)GAAAC synonymous-codon, reference, nc-transcript-variant
rs720634 -- 224,015,001(+) TTCAC(C/T)ACTAG intron-variant
rs729631 -- 223,980,202(-) AGGCA(C/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINE2 Gene

Variant ID Type Subtype PubMed ID
nsv875898 CNV Gain 21882294
nsv213199 CNV Loss 16902084

Relevant External Links for SERPINE2 Gene

HapMap Linkage Disequilibrium report
SERPINE2

Disorders for SERPINE2 Gene

(2) University of Copenhagen DISEASES for SERPINE2 Gene

(10) Novoseek inferred disease relationships for SERPINE2 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 34.8 9
senile plaques 27.5 1
astrocytoma 25.1 4
amyotrophic lateral sclerosis 22.3 1
glioblastoma 9.01 2

Relevant External Links for SERPINE2

Genetic Association Database (GAD)
SERPINE2
Human Genome Epidemiology (HuGE) Navigator
SERPINE2
genes like me logo Genes that share disorders with SERPINE2: view

No data available for UniProtKB/Swiss-Prot for SERPINE2 Gene

Publications for SERPINE2 Gene

  1. The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes. (PMID: 7665170) Carter R.E. … Festoff B.W. (Genomics 1995) 2 3 23
  2. The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. (PMID: 17446335) Zhu G. … Pillai S.G. (Am. J. Respir. Crit. Care Med. 2007) 3 23 49
  3. Genetic associations with hypoxemia and pulmonary arterial pressure in COPD. (PMID: 19017876) Castaldi P.J. … Silverman E.K. (Chest 2009) 3 23 49
  4. Polymorphic variation in surfactant protein B is associated with COPD exacerbations. (PMID: 18550614) Foreman M.G. … Silverman E.K. (Eur. Respir. J. 2008) 3 23 49
  5. Macrophages and platelets are the major source of protease nexin-1 in human atherosclerotic plaque. (PMID: 18617644) Mansilla S. … Bouton M.C. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 23

Products for SERPINE2 Gene

Sources for SERPINE2 Gene

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