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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINE2 Gene

protein-coding   GIFtS: 61
GCID: GC02M224839

serpin peptidase inhibitor, clade E (nexin, plasminogen...

(Previous names: serine (or cysteine) proteinase inhibitor, clade E (nexin,...)
(Previous symbol: PI7)
 Explore 38 diseases affiliated with
SERPINE2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SERPINE2    

Aliases
for SERPINE2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor
Type 1), Member 21 2
     PI-72 3
PI71 2 3 5     PN-12 3
PN11 2 3 5     Nexin1
GDN1 2 3     Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen
Activator Inhibitor Type 1), Member 21
PNI1 2     GDNPF2
Peptidase Inhibitor 72 3     Glia-Derived Nexin2
Protease Nexin I2 3     Glial-Derived Neurite Promoting Factor2
Serpin E22 3     Protease Nexin 13

External Ids:    HGNC: 89511   Entrez Gene: 52702   Ensembl: ENSG000001359197   OMIM: 1770105   UniProtKB: P070933   

Export aliases for SERPINE2 gene to outside databases

Previous GC identifers: GC02M222862 GC02M223560 GC02M224803 GC02M225042 GC02M224665 GC02M224548 GC02M216691


Summaries
for SERPINE2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SERPINE2:
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases.
Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a
susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Aug 2012)

UniProtKB/Swiss-Prot: GDN_HUMAN, P07093
Function: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension
by inhibiting thrombin. Binds heparin

Gene Wiki entry for SERPINE2


Genomic Views
for SERPINE2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINE2 gene promoter:
         RORalpha1   Nkx3-1   FAC1   Chx10   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SERPINE2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINE2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q36.1

SERPINE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINE2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M224839:  view genomic region     (about GC identifiers)

Start:
 224,839,765 bp from pter      End:
 224,904,036 bp from pter
Size:
 64,272 bases      Orientation:
 minus strand

Proteins
for SERPINE2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GDN_HUMAN, P07093 (See protein sequence)
Recommended Name: Glia-derived nexin precursor  
Size: 398 amino acids; 44002 Da
Subcellular location: Secreted, extracellular space
2 PDB 3D structures from and Proteopedia for SERPINE2:
4DY0 (3D)        4DY7 (3D)    
Secondary accessions: B2R6A4 B4DIF2 Q53S15 Q5D0C4
Alternative splicing: 3 isoforms:  P07093-1   P07093-2   P07093-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SERPINE2: NX_P07093

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P07093

    • SERPINE2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001130000.1  NP_001130002.1  NP_006207.1  

    ENSEMBL proteins: 
     ENSP00000386412   ENSP00000258405   ENSP00000386969   ENSP00000415786   ENSP00000408452  
     ENSP00000399655   ENSP00000394518  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SERPINE2 (Serpin E2/PN1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SERPINE2
    OriGene Protein Over-expression Lysate: SERPINE2
    OriGene Custom Protein Services for SERPINE2 
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    Novus Biologicals SERPINE2 Proteins
    Novus Biologicals SERPINE2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SERPINE2

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA3997857
    GO:0005615extracellular space IBA--
    GO:0005624membrane fraction ----
    GO:0005829cytosol IDA19855083
    GO:0031012extracellular matrix IDA3279057


    SERPINE2 for ontologies           About GeneDecksing



    SERPINE2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SERPINE2 (Serpin E2/PN1)
    OriGene Antibodies (see all 6): SERPINE2
    OriGene Custom Antibody Services for SERPINE2 
    GenScript Custom Superior Antibodies Services for SERPINE2
    Novus Biologicals SERPINE2 Antibodies
    Abcam antibodies for SERPINE2 
    Uscn Antibodies for SERPINE2
    Search ThermoFisher Antibodies for SERPINE2

    Assay Products for SERPINE2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for SERPINE2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SERPINE2

    Protein Domains /
    Families
    for SERPINE2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SERPINE2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P07093

    ProtoNet protein and cluster: P07093

    1 Blocks protein family: IPB000215 Serpin

    UniProtKB/Swiss-Prot: GDN_HUMAN, P07093
    Similarity: Belongs to the serpin family


    Function
    for SERPINE2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GDN_HUMAN, P07093
    Function: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension
    by inhibiting thrombin. Binds heparin

    miRNA
    Products:            		miRTarBase miRNAs that target SERPINE2:
    hsa-mir-16 (MIRT001419)

    OriGene 3'-UTR Clone (see all 4): SERPINE2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINE2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINE2:
    hsa-miR-3606 hsa-miR-1244 hsa-miR-222* hsa-miR-199b-3p hsa-miR-936 hsa-miR-199a-3p hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SERPINE2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINE2 (see all 7)
    OriGene shRNA RFP: SERPINE2
    OriGene siRNA: SERPINE2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINE2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SERPINE2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINE2 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): SERPINE2 (NM_006216)
    Sino Biological Human cDNA Clone for SERPINE2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINE2 

    Cell Line
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    Search LifeMap BioReagents cell lines for SERPINE2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE2

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IMP19855083
    GO:0005102receptor binding IPI17379830
    GO:0005515protein binding IPI3279057
    GO:0005539glycosaminoglycan binding IDA19855083
    GO:0008201heparin binding IDA3997857


    SERPINE2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Serpine2tm1Dmn for SERPINE2
         8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Serpine2):
     behavior/neurological  cellular  endocrine/exocrine gland  homeostasis/metabolism  immune system 
     nervous system  no phenotypic analysis  reproductive system 

    SERPINE2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SERPINE2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_ECM remodeling
    		Cell adhesion_ECM remodeling1.00
    		Cell adhesion ECM remodeling1.00
    2Development_CNTF receptor signaling
    		Cell adhesion PLAU signaling0.35
    		Cell adhesion_PLAU signaling0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for SERPINE2
        Cell adhesion PLAU signaling
    Cell adhesion ECM remodeling


    2 GeneGo (Thomson Reuters) Pathways for SERPINE2
        Cell adhesion PLAU signaling
    Cell adhesion ECM remodeling



    SERPINE2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for SERPINE2 (P070933 ENSP000004157864) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLAUP007493, ENSP000003618504I2D: score=1 STRING: ENSP00000361850
    COL4A1P024623, ENSP000003649794I2D: score=1 STRING: ENSP00000364979
    COL4A2P085723, ENSP000003536544I2D: score=1 STRING: ENSP00000353654
    COL4A3Q019553, ENSP000003798234I2D: score=1 STRING: ENSP00000379823
    F2ENSP000003085414STRING: ENSP00000308541
    About this table

    Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007566embryo implantation ----
    GO:0007596blood coagulation IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0009314response to radiation ----
    GO:0009611response to wounding ----


    SERPINE2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SERPINE2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINE2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINE2
    10 Novoseek chemical compound relationships for SERPINE2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 74.2 49 1620346 (2), 12506347 (2), 8549675 (2), 7846074 (1) (see all 37)
    heparin 43.9 37 1554734 (6), 10867020 (3), 8216224 (2), 10973954 (2) (see all 10)
    cycloheximide 17.3 2 8360185 (2)
    glycosaminoglycan 16.2 2 8384402 (1), 9813026 (1)
    actinomycin d 12.9 1 8360185 (1)
    tetrodotoxin 10.7 1 8738754 (1)
    lipid 0 1 10867020 (1)
    calcium 0 1 16420559 (1)
    polysaccharide 0 3 16493483 (3)
    acetylcholine 0 2 7524091 (1)

    Search CenterWatch for drugs/clinical trials and news about SERPINE2 / GDN 

    Transcripts
    for SERPINE2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SERPINE2 gene (3 alternative transcripts): 
    NM_001136528.1  NM_001136530.1  NM_006216.3  

    Unigene Clusters for SERPINE2:

    Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
    Hs.38449  [show with all ESTs], Hs.708453  [show with all ESTs]
    Unigene Representative Sequences: NR_073116, DC427451
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409304(uc010zlr.1) ENST00000258405(uc002vnu.2 uc002vnv.2)
    ENST00000473202 ENST00000409840 ENST00000447280 ENST00000478966 ENST00000432738
    ENST00000489065 ENST00000454956 ENST00000423446

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): SERPINE2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINE2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINE2:
    hsa-miR-3606 hsa-miR-1244 hsa-miR-222* hsa-miR-199b-3p hsa-miR-936 hsa-miR-199a-3p hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SERPINE2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINE2 (see all 7)
    OriGene shRNA RFP: SERPINE2
    OriGene siRNA: SERPINE2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINE2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINE2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINE2 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): SERPINE2 (NM_006216)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINE2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINE2

    Additional cDNA sequence: AJ293400.1 

    16 DOTS entries:

    DT.40109604  DT.97855998  DT.100655728  DT.91978574  DT.120974424  DT.120974421  DT.120974425  DT.100655727 
    DT.101985307  DT.95181913  DT.100655724  DT.120974436  DT.95181888  DT.95181893  DT.95181910  DT.100034738 

    24/391 AceView cDNA sequences (see all 391):

    BU184307 CA432434 CR604360 AA650628 AA383786 BU153455 AW769819 CR592428 
    CD677652 T53495 CD515558 CF131696 BX398988 BU189529 CR592106 CR625696 
    BE277479 AL553882 AI919184 BI545330 CR623305 CR596542 BP353222 CB155858 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINE2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                                      -     -                 -     -                       -                 -                                             
    SP2:                    -     -     -     -     -     -     -     -     -                       -                 -                                             
    SP3:                                                                                            -                                                               
    SP4:                          -     -     -     -     -     -     -     -                       -                 -                                             
    SP5:                                                                                                                                                            

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SERPINE2

    Expression
    for SERPINE2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTCACTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SERPINE2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePerivenous HepatocytesLiver
    LungRespiratory BronchiolesBasal CellsLung
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BoneAutopod Long BoneBone
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    LimbAutopodLimb
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Endoderm-like cells (Generation of hepato...)
    Definitive endoderm-like cells (A scalable, suspensi...)

    See SERPINE2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINE2

    SOURCE GeneReport for Unigene clusters: Hs.38449 Hs.708453
        SABiosciences Custom PCR Arrays for SERPINE2
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINE2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE2

    Orthologs
    for SERPINE2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SERPINE2 gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SERPINE21 serpin peptidase inhibitor, clade E (nexin, plasminogen more 76.46(n)
    79.49(a)    		   424805  NM_001083920.1  NP_001077389.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SERPINE26
    		 --
    		 78(a)
    		 1 ↔ 1
    		 3(25000834-25013178)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.120452 Xenopus laevis transcribed sequence with weak similarity more 75.91(n)    BU916470.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc559292 similar to serine (or cysteine) proteinase inhibitor, more 71.44(n)   393153  BC045498.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta nec3 antifungal humoral response (sensu
    Invertebrata) more    		 30(a)   43A1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea srp-66
    srp-26
    (see all 6)    		 SeRPin family member (srp-2)
    (see all 6)    		 25(a)
    25(a)
    (see all 6)    		 possible ortholog
    possible ortholog
    (see all 6)    		 V(7384214-7386288)
    V(762735-764658)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G640106
    AT2G252406
    (see all 10)    		 serpin-Z10
    (see all 10)    		 26(a)
    25(a)
    (see all 10)    		 many ↔ many
    many ↔ many
    (see all 10)    		 1(23750884-23751441)
    2(10751768-10753134)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 16)    		 serpin domain containing protein, putative, expres...
    serpin domain containing protein, putative, expres...
    (see all 16)    		 24(a)
    23(a)
    (see all 16)    		 many ↔ many
    many ↔ many
    (see all 16)    		 3(23053071-23066803)
    1(32248927-32250581)


    ENSEMBL Gene Tree for SERPINE2 (if available)
    TreeFam Gene Tree for SERPINE2 (if available) 

    Paralogs
    for SERPINE2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINE2 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB32  SERPINB42  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINE32  SERPINB132  
    SERPINB82  
    18/19 SIMAP similar genes for SERPINE2 using alignment to 4 protein entries:     GDN_HUMAN (see all proteins) (see all similar genes):
    SERPINE1    SERPINI1    SERPINI2    SERPINA9    SERPINB11    SERPINB6
    SERPINB9    SERPINB1    SERPINB3    SERPINC1    SERPINB8    SERPINB4
    SCCA2    SERPINA10    SERPINB12    SERPINE3    SERPINB10    SERPINB13

    SERPINE2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SERPINE2
    PGOHUM00000247016


    Genomic Variants
    for SERPINE2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1314 NCBI SNPs in SERPINE2 are shown (see all 1314)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs567994191,2
    		C,F,--216692193(+) TGCATC/TGAGTC 4 -- nc-transcript-variantut311Minor allele frequency- T:0.06WA 118
    rs1128225501,2
    		--216692264(+) AAAGAG/TGCAGG 4 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.50CSA 2
    rs124683791,2
    		C,F,H,--216692543(+) agcatG/Agtagc 4 -- int19Minor allele frequency- A:0.03NS EA WA NA CSA 546
    rs2015088031,2
    		C--216693683(-) ATTTTG/TCTAGA 4 -- int10--------
    rs124707391,2
    		C,F,H,--216694780(+) GCCACC/TGCGCC 4 -- int13Minor allele frequency- T:0.50NA WA CSA 8
    rs786468851,2
    		--216694904(+) TGCACC/TGGAAT 4 -- int10--------
    rs784037911,2
    		F,--216694939(+) TACCTT/AATACT 4 -- int11Minor allele frequency- A:0.03EA 120
    rs124751171,2
    		C,F,H,--216695146(+) AAGTAT/CTGAAC 4 -- int124Minor allele frequency- C:0.15NS EA NA WA 2580
    rs168653881,2
    		C,F,H,--216696709(+) CCAATG/AAGTAT 4 -- int113Minor allele frequency- A:0.04NA NS EA WA 1444
    rs348765211,2
    		C,F,--216697320(+) GCTAGT/-TAGTG 4 -- int12Minor allele frequency- -:0.50NA CSA 4

    HapMap Linkage Disequilibrium report for SERPINE2 (224839765 - 224904036 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SERPINE2
         1 CNV: 6033

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    Disorders / Diseases
    for SERPINE2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SERPINE2 for disorders           About GeneDecksing

    OMIM gene information: 177010    OMIM disorders: --

    20/38 diseases for SERPINE2 (see all 38):    About MalaCards
    chronic obstructive pulmonary disease    pulmonary disease    emphysema    familial encephalopathy with neuroserpin inclusion bodies
    alpha 1-antitrypsin deficiency    primary ciliary dyskinesia    amyotrophic lateral sclerosis    ciliary dyskinesia
    lateral sclerosis    oral squamous cell carcinoma    kartagener syndrome    squamous cell carcinoma
    brain edema    hepatopulmonary syndrome    cystic fibrosis    cerebral infarction
    celiac disease    alzheimer's disease    testicular cancer    neurodegeneration

    1 disease from the University of Copenhagen DISEASES database for SERPINE2:
    Chronic obstructive pulmonary disease

    10 Novoseek disease relationships for SERPINE2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 34.8 9 10037469 (2), 7846074 (1), 1620346 (1), 2180485 (1) (see all 8)
    senile plaques 27.5 1 1620346 (1)
    astrocytoma 25.1 4 10037469 (2), 11814314 (1), 11939722 (1)
    amyotrophic lateral sclerosis 22.3 1 8549675 (1)
    glioblastoma 9.01 2 7506041 (1), 1987320 (1)
    glioma 7.88 2 8456423 (1), 8940166 (1)
    neurodegeneration 1.23 1 7670362 (1)
    necrosis 0 4 8429047 (2), 11814314 (1), 10228949 (1)
    atrophy 0 1 7846074 (1)
    tumors 0 12 16737540 (4), 8429047 (2), 2037625 (1), 2116223 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: SERPINE2 (18 documents)

    Export disorders for SERPINE2 gene to outside databases

    Publications
    for SERPINE2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINE2 gene, integrated from 9 sources (see all 160):
    (articles sorted by number of sources associating them with SERPINE2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes. (PubMed id 7665170)1, 3, 9 Carter R.E....Festoff B.W. (1995)
    2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily. (PubMed id 3427015)1, 2 Sommer J....Monard D. (1987)
    5. A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins. (PubMed id 2877744)1, 2 Gloor S.M.... Monard D. (1986)
    6. Protease nexin. Properties and a modified purification procedure. (PubMed id 3997857)1, 2 Scott R.W.... Baker J.B. (1985)
    7. Regulation of protease nexin-1 target protease specificity by collagen type IV. (PubMed id 8006028)1, 9 Donovan F.M....Cunningham D.D. (1994)
    8. Macrophages and platelets are the major source of protease nexin-1 in human atherosclerotic plaque. (PubMed id 18617644)1, 9 Mansilla S....Bouton M.C. (2008)
    9. Anticoagulant and antithrombotic properties of platel et protease nexin-1. (PubMed id 19855083)1, 9 Boulaftali Y....Bouton M.C. (2010)
    10. Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect. (PubMed id 17379830)1, 9 Bouton M.C....Jandrot-Perrus M. (2007)

    External Searches for SERPINE2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing SERPINE2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5270 HGNC: 8951 AceView: SERPINE2 Ensembl:ENSG00000135919 euGenes: HUgn5270
    ECgene: SERPINE2 H-InvDB: SERPINE2

    Other Databases showing SERPINE2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SERPINE2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINE2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SERPINE2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SERPINE2 gene:
    Search GeneIP for patents involving SERPINE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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