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Aliases for SERPINE2 Gene

Aliases for SERPINE2 Gene

  • Serpin Family E Member 2 2 3
  • Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 2 2 3 5
  • Peptidase Inhibitor 7 3 4
  • Protease Nexin I 3 4
  • Serpin E2 3 4
  • PI-7 3 4
  • PN-1 3 4
  • PI7 3 4
  • GDN 3 4
  • PN1 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 2 2
  • Glial-Derived Neurite Promoting Factor 3
  • Glial-Derived Nexin 1 2
  • Protease Nexin 1 4
  • GDNPF 3
  • PNI 3

External Ids for SERPINE2 Gene

Previous HGNC Symbols for SERPINE2 Gene

  • PI7

Previous GeneCards Identifiers for SERPINE2 Gene

  • GC02M222862
  • GC02M223560
  • GC02M224803
  • GC02M225042
  • GC02M224665
  • GC02M224548
  • GC02M224839
  • GC02M216691

Summaries for SERPINE2 Gene

Entrez Gene Summary for SERPINE2 Gene

  • This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for SERPINE2 Gene

SERPINE2 (Serpin Family E Member 2) is a Protein Coding gene. Diseases associated with SERPINE2 include Alzheimer Disease and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Platelet activation, signaling and aggregation. GO annotations related to this gene include receptor binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINI1.

UniProtKB/Swiss-Prot for SERPINE2 Gene

  • Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Gene Wiki entry for SERPINE2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINE2 Gene

Genomics for SERPINE2 Gene

Regulatory Elements for SERPINE2 Gene

Enhancers for SERPINE2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SERPINE2 on UCSC Golden Path with GeneCards custom track

Promoters for SERPINE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SERPINE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERPINE2 Gene

Chromosome:
2
Start:
223,975,048 bp from pter
End:
224,039,319 bp from pter
Size:
64,272 bases
Orientation:
Minus strand

Genomic View for SERPINE2 Gene

Genes around SERPINE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINE2 Gene

Proteins for SERPINE2 Gene

  • Protein details for SERPINE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07093-GDN_HUMAN
    Recommended name:
    Glia-derived nexin
    Protein Accession:
    P07093
    Secondary Accessions:
    • B2R6A4
    • B4DIF2
    • Q53S15
    • Q5D0C4

    Protein attributes for SERPINE2 Gene

    Size:
    398 amino acids
    Molecular mass:
    44002 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SERPINE2 Gene

    Alternative splice isoforms for SERPINE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINE2 Gene

Proteomics data for SERPINE2 Gene at MOPED

Post-translational modifications for SERPINE2 Gene

  • Glycosylation at Asn 118 and Asn 159
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SERPINE2 (Serpin E2/PN1)

No data available for DME Specific Peptides for SERPINE2 Gene

Domains & Families for SERPINE2 Gene

Gene Families for SERPINE2 Gene

Protein Domains for SERPINE2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINE2 Gene

Graphical View of Domain Structure for InterPro Entry

P07093

UniProtKB/Swiss-Prot:

GDN_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINE2: view

Function for SERPINE2 Gene

Molecular function for SERPINE2 Gene

UniProtKB/Swiss-Prot Function:
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
genes like me logo Genes that share phenotypes with SERPINE2: view

Animal Models for SERPINE2 Gene

MGI Knock Outs for SERPINE2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SERPINE2

CRISPR Products

miRNA for SERPINE2 Gene

miRTarBase miRNAs that target SERPINE2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINE2 Gene

Localization for SERPINE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINE2 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINE2 Gene COMPARTMENTS Subcellular localization image for SERPINE2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SERPINE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0031091 platelet alpha granule IMP 19855083
genes like me logo Genes that share ontologies with SERPINE2: view

Pathways & Interactions for SERPINE2 Gene

genes like me logo Genes that share pathways with SERPINE2: view

Gene Ontology (GO) - Biological Process for SERPINE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007566 embryo implantation IEA --
GO:0007596 blood coagulation IEA,TAS --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0009314 response to radiation IEA --
GO:0009611 response to wounding IEA --
genes like me logo Genes that share ontologies with SERPINE2: view

No data available for SIGNOR curated interactions for SERPINE2 Gene

Drugs & Compounds for SERPINE2 Gene

(5) Drugs for SERPINE2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for SERPINE2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINE2: view

Transcripts for SERPINE2 Gene

Unigene Clusters for SERPINE2 Gene

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINE2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - -
SP2: - - - - - - - - - - -
SP3: -
SP4: - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - - - -
SP10: - - - - - - - - -

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for SERPINE2 Gene

GeneLoc Exon Structure for
SERPINE2
ECgene alternative splicing isoforms for
SERPINE2

Expression for SERPINE2 Gene

mRNA expression in normal human tissues for SERPINE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERPINE2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (15.7), Amniocyte (12.1), and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINE2 Gene



SOURCE GeneReport for Unigene cluster for SERPINE2 Gene Hs.38449

genes like me logo Genes that share expression patterns with SERPINE2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SERPINE2 Gene

Orthologs for SERPINE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SERPINE2 35
  • 88.16 (n)
  • 91.69 (a)
SERPINE2 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINE2 35
  • 86.6 (n)
  • 91.32 (a)
SERPINE2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpine2 35
  • 84.21 (n)
  • 85.39 (a)
Serpine2 16
Serpine2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERPINE2 35
  • 99.43 (n)
  • 99.51 (a)
SERPINE2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpine2 35
  • 83.29 (n)
  • 84.38 (a)
oppossum
(Monodelphis domestica)
Mammalia SERPINE2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINE2 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERPINE2 35
  • 76.46 (n)
  • 79.49 (a)
SERPINE2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERPINE2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76024 35
serpine2 35
  • 68.72 (n)
  • 72.75 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12045 35
zebrafish
(Danio rerio)
Actinopterygii serpine2 35
  • 59.15 (n)
  • 54.66 (a)
zgc55929 35
serpine2 36
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6921 35
fruit fly
(Drosophila melanogaster)
Insecta nec 37
  • 30 (a)
Species with no ortholog for SERPINE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINE2 Gene

ENSEMBL:
Gene Tree for SERPINE2 (if available)
TreeFam:
Gene Tree for SERPINE2 (if available)

Paralogs for SERPINE2 Gene

Paralogs for SERPINE2 Gene

Pseudogenes.org Pseudogenes for SERPINE2 Gene

genes like me logo Genes that share paralogs with SERPINE2: view

Variants for SERPINE2 Gene

Sequence variations from dbSNP and Humsavar for SERPINE2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_036027 A breast cancer sample
rs3795875 - 224,001,748(-) AACAT(C/G/T)GTGAT nc-transcript-variant, reference, synonymous-codon, missense
rs720634 -- 224,015,001(+) TTCAC(C/T)ACTAG intron-variant, upstream-variant-2KB
rs1550308 -- 224,026,230(+) acttc(A/G)ggctt intron-variant
rs729631 -- 223,980,202(-) AGGCA(C/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINE2 Gene

Variant ID Type Subtype PubMed ID
nsv875898 CNV Gain 21882294
nsv213199 CNV Loss 16902084

Variation tolerance for SERPINE2 Gene

Residual Variation Intolerance Score: 22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SERPINE2 Gene

Disorders for SERPINE2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SERPINE2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SERPINE2

Genetic Association Database (GAD)
SERPINE2
Human Genome Epidemiology (HuGE) Navigator
SERPINE2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINE2
genes like me logo Genes that share disorders with SERPINE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINE2 Gene

Publications for SERPINE2 Gene

  1. The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes. (PMID: 7665170) Carter R.E. … Festoff B.W. (Genomics 1995) 2 3 23 67
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  3. Anticoagulant and antithrombotic properties of platelet protease nexin-1. (PMID: 19855083) Boulaftali Y. … Bouton M.C. (Blood 2010) 3 23
  4. Genetic associations with hypoxemia and pulmonary arterial pressure in COPD. (PMID: 19017876) Castaldi P.J. … Silverman E.K. (Chest 2009) 3 23
  5. Specificity of binding of the low density lipoprotein receptor-related protein to different conformational states of the clade E serpins plasminogen activator inhibitor-1 and proteinase nexin-1. (PMID: 19439404) Jensen J.K. … Gettins P.G. (J. Biol. Chem. 2009) 3 23

Products for SERPINE2 Gene

Sources for SERPINE2 Gene

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