Aliases for SERPINE2 Gene
External Ids for SERPINE2 Gene
Previous Symbols for SERPINE2 Gene
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for SERPINE2 Gene
SERPINE2 (Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 2) is a Protein Coding gene. Among its related pathways are Hemostasis and Translation Insulin regulation of translation. GO annotations related to this gene include receptor binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.
UniProtKB/Swiss-Prot for SERPINE2 Gene
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin