Aliases for SERPINE2 Gene
External Ids for SERPINE2 Gene
Previous HGNC Symbols for SERPINE2 Gene
Previous GeneCards Identifiers for SERPINE2 Gene
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for SERPINE2 Gene
SERPINE2 (Serpin Family E Member 2) is a Protein Coding gene. Diseases associated with SERPINE2 include alzheimer disease and amyotrophic lateral sclerosis 1. Among its related pathways are Platelet activation, signaling and aggregation and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include receptor binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINI1.
UniProtKB/Swiss-Prot for SERPINE2 Gene
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.