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SERPINE2 Gene

protein-coding   GIFtS: 62
GCID: GC02M224839

Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen...

(Previous names: serine (or cysteine) proteinase inhibitor, clade E (nexin,...)
(Previous symbol: PI7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator
Inhibitor Type 1), Member 21 2
     PN-12 3
PI71 2 3 5     Glial-Derived Nexin 11
PN12 3 5     Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen
Activator Inhibitor Type 1), Member 21
Peptidase Inhibitor 72 3     GDNPF2
Protease Nexin I2 3     PNI2
Serpin E22 3     Glia-Derived Nexin2
GDN2 3     Glial-Derived Neurite Promoting Factor2
PI-72 3     Protease Nexin 13

External Ids:    HGNC: 89511   Entrez Gene: 52702   Ensembl: ENSG000001359197   OMIM: 1770105   UniProtKB: P070933   

Export aliases for SERPINE2 gene to outside databases

Previous GC identifers: GC02M222862 GC02M223560 GC02M224803 GC02M225042 GC02M224665 GC02M224548 GC02M216691


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SERPINE2 Gene:
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases.
Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene
is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for SERPINE2 Gene:
SERPINE2 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2) is a protein-coding gene. Diseases associated with SERPINE2 include familial encephalopathy with neuroserpin inclusion bodies, and brain edema. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and receptor binding. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: GDN_HUMAN, P07093
Function: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite
extension by inhibiting thrombin. Binds heparin

Gene Wiki entry for SERPINE2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERPINE2 gene promoter:
         RORalpha1   Nkx3-1   FAC1   Chx10   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINE2 promoter sequence
   Search Chromatin IP Primers for SERPINE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERPINE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q36.1

SERPINE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINE2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M224839:  view genomic region     (about GC identifiers)

Start:
224,839,765 bp from pter      End:
224,904,036 bp from pter
Size:
64,272 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GDN_HUMAN, P07093 (See protein sequence)
Recommended Name: Glia-derived nexin precursor  
Size: 398 amino acids; 44002 Da
2 PDB 3D structures from and Proteopedia for SERPINE2:
4DY0 (3D)        4DY7 (3D)    
Secondary accessions: B2R6A4 B4DIF2 Q53S15 Q5D0C4
Alternative splicing: 3 isoforms:  P07093-1   P07093-2   P07093-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SERPINE2: NX_P07093

Explore proteomics data for SERPINE2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn118, Asn159
  • Modification sites at PhosphoSitePlus

  • See SERPINE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001130000.1  NP_001130002.1  NP_006207.1  

    ENSEMBL proteins: 
     ENSP00000386412   ENSP00000258405   ENSP00000386969   ENSP00000415786   ENSP00000408452  
     ENSP00000399655   ENSP00000394518  
    Reactome Protein details: P07093

    SERPINE2 Human Recombinant Protein Products:

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    Novus Biologicals SERPINE2 Proteins
    Novus Biologicals SERPINE2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SERPINE2 Antibody Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Serpin_CS
     IPR000215 Serpin_fam
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry P07093

    ProtoNet protein and cluster: P07093

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: GDN_HUMAN, P07093
    Similarity: Belongs to the serpin family


    SERPINE2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GDN_HUMAN, P07093
    Function: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite
    extension by inhibiting thrombin. Binds heparin

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IMP19855083
    GO:0005102receptor binding IPI17379830
    GO:0005515protein binding IPI19911255
    GO:0005539glycosaminoglycan binding IDA19855083
    GO:0008201heparin binding IDA1939253
         
    SERPINE2 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Serpine2):
     behavior/neurological  cellular  endocrine/exocrine gland  homeostasis/metabolism  immune system 
     nervous system  no phenotypic analysis  reproductive system 

    SERPINE2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Serpine2tm1Dmn for SERPINE2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERPINE2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SERPINE2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINE2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERPINE2

    miRNA
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    miRTarBase miRNAs that target SERPINE2:
    hsa-mir-30e-3p (MIRT044124), hsa-mir-16-5p (MIRT001419), hsa-mir-30a-5p (MIRT028560)

    Block miRNA regulation of human, mouse, rat SERPINE2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SERPINE2:
    hsa-miR-3606 hsa-miR-1244 hsa-miR-222* hsa-miR-199b-3p hsa-miR-936 hsa-miR-199a-3p hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmidSERPINE2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SERPINE2
    Predesigned siRNA for gene silencing in human, mouse, rat SERPINE2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): SERPINE2 (NM_006216)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINE2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SERPINE2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GDN_HUMAN, P07093: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol4
    plasma membrane4
    cytoskeleton2
    endosome2
    golgi apparatus1
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA19855083
    GO:0005615extracellular space IBA--
    GO:0005829cytosol IDA19855083
    GO:0031012extracellular matrix IDA3279057
    GO:0031091platelet alpha granule IMP19855083

    SERPINE2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SERPINE2 About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Translation Insulin regulation of translation
    Cell adhesion PLAU signaling0.35
    3Cell adhesion ECM remodeling
    Cell adhesion ECM remodeling0.31
    4Dissolution of Fibrin Clot
    Dissolution of Fibrin Clot

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for SERPINE2
        Cell adhesion PLAU signaling
    Cell adhesion ECM remodeling

    1 Reactome Pathway for SERPINE2
        Dissolution of Fibrin Clot



    SERPINE2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERPINE2
    Interactions:

        GeneGlobe Interaction Network for SERPINE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SERPINE2 (P070933 ENSP000004157864) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLAUP007493, ENSP000003618504I2D: score=1 STRING: ENSP00000361850
    COL4A1P024623, ENSP000003649794I2D: score=1 STRING: ENSP00000364979
    COL4A2P085723, ENSP000003536544I2D: score=1 STRING: ENSP00000353654
    COL4A3Q019553, ENSP000003798234I2D: score=1 STRING: ENSP00000379823
    F2ENSP000003085414STRING: ENSP00000308541
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0009611response to wounding ----
    GO:0010466negative regulation of peptidase activity ----
    GO:0010544negative regulation of platelet activation IEA--

    SERPINE2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERPINE2 (GDN)

    10 Novoseek inferred chemical compound relationships for SERPINE2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 74.2 49 1620346 (2), 12506347 (2), 8549675 (2), 7846074 (1) (see all 37)
    heparin 43.9 37 1554734 (6), 10867020 (3), 8216224 (2), 10973954 (2) (see all 10)
    cycloheximide 17.3 2 8360185 (2)
    glycosaminoglycan 16.2 2 8384402 (1), 9813026 (1)
    actinomycin d 12.9 1 8360185 (1)
    tetrodotoxin 10.7 1 8738754 (1)
    lipid 0 1 10867020 (1)
    calcium 0 1 16420559 (1)
    polysaccharide 0 3 16493483 (3)
    acetylcholine 0 2 7524091 (1)



    SERPINE2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SERPINE2 gene (3 alternative transcripts): 
    NM_001136528.1  NM_001136530.1  NM_006216.3  

    Unigene Cluster for SERPINE2:

    Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
    Hs.38449  [show with all ESTs]
    Unigene Representative Sequence: NR_073116
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409304(uc010zlr.1) ENST00000258405(uc002vnu.2 uc002vnv.2)
    ENST00000473202 ENST00000409840 ENST00000447280 ENST00000478966 ENST00000432738
    ENST00000489065 ENST00000454956 ENST00000423446
    miRNA
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    Block miRNA regulation of human, mouse, rat SERPINE2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SERPINE2:
    hsa-miR-3606 hsa-miR-1244 hsa-miR-222* hsa-miR-199b-3p hsa-miR-936 hsa-miR-199a-3p hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmidSERPINE2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SERPINE2
    Predesigned siRNA for gene silencing in human, mouse, rat SERPINE2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINE2
    Primer
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    OriGene qPCR primer pairs and template standards for SERPINE2
    OriGene qSTAR qPCR primer pairs in human, mouse for SERPINE2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERPINE2
      QuantiTect SYBR Green Assays in human, mouse, rat SERPINE2
      QuantiFast Probe-based Assays in human, mouse, rat SERPINE2

    Additional mRNA sequence: 

    AK225823.1 AK295564.1 AK297588.1 AK312499.1 BC015663.2 BC042628.1 M17783.1 NR_073116.1 

    16 DOTS entries:

    DT.40109604  DT.97855998  DT.100655728  DT.91978574  DT.120974424  DT.120974421  DT.120974425  DT.100655727 
    DT.101985307  DT.95181913  DT.100655724  DT.120974436  DT.95181893  DT.95181910  DT.100034738  DT.95181888 

    Selected AceView cDNA sequences (see all 391):

    BG680180 T53495 CR592106 BX398988 CD677652 CF131696 CR625696 BQ441079 
    CD515558 BQ214935 BI545330 CN482939 AI919184 CR623305 BP353222 AV703789 
    BE891001 BU189529 CB155858 CA432434 AA650628 AA383786 CR596542 CR592548 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SERPINE2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                                      -     -                 -     -                       -                 -                                             
    SP2:                    -     -     -     -     -     -     -     -     -                       -                 -                                             
    SP3:                                                                                            -                                                               
    SP4:                          -     -     -     -     -     -     -     -                       -                 -                                             
    SP5:                                                                                                                                                            

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SERPINE2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SERPINE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCACTAA
    SERPINE2 Expression
    About this image


    SERPINE2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Medulla Oblongata
     
     Endoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Endoderm-like cells
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
    SERPINE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERPINE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.38449
        Custom PCR Arrays for SERPINE2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINE2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpine21 , 5 serine (or cysteine) peptidase inhibitor, clade E, more1, 5 84.21(n)1
    85.39(a)1
      1 (40.97 cM)5
    207201  NM_009255.41  NP_033281.11 
     797941975 
    chicken
    (Gallus gallus)
    Aves SERPINE21 serpin peptidase inhibitor, clade E (nexin, plasminogen more 76.46(n)
    79.49(a)
      424805  NM_001083920.1  NP_001077389.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERPINE26
    serpin peptidase inhibitor, clade E (nexin, plasmi...
    78(a)
    1 ↔ 1
    3(24982669-25016225)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120452 Xenopus laevis transcribed sequence with weak similarity more 75.91(n)    BU916470.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559292 similar to serine (or cysteine) proteinase inhibitor, more 71.44(n)   393153  BC045498.1 


    ENSEMBL Gene Tree for SERPINE2 (if available)
    TreeFam Gene Tree for SERPINE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERPINE2 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB32  SERPINB42  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINB112  SERPINE32  
    SERPINB132  SERPINB82  
    Selected SIMAP similar genes for SERPINE2 using alignment to 4 protein entries:     GDN_HUMAN (see all proteins) (see all similar genes):
    SERPINE1    SERPINI1    SERPINI2    SERPINA9    SERPINB11    SERPINB6
    SERPINB9    SERPINB1    SERPINB3    SERPINC1    SERPINB8    SERPINB4
    SCCA2    SERPINA10    SERPINB12    SERPINE3    SERPINB10    SERPINB13

    SERPINE2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SERPINE2
    PGOHUM00000247016


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERPINE2 (see all 1582)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360274
    A breast cancer sample4--see VAR_0360272 K N mis40--------
    rs1381022541,2
    C--216718445(+) TCCCC-/CAGAT 
            
    AGAGA
    4 -- int10--------
    rs105457131,2
    C--216718446(+) ccccc-/AGAT  
            
    agaga
    4 -- int10--------
    rs557332451,2
    C--216718449(+) CCAGA-/TAGA  
            
    GACTC
    4 -- int10--------
    rs30800921,2
    C--216721502(+) tatatA/Tttata 4 -- int13Minor allele frequency- T:0.00NA 6
    rs2017860821,2
    C--216721515(+) ATATT-/ATATAT
    ATATATATA
    TATAT
    4 -- int10--------
    rs1117874821,2
    C--216721544(+) ATATAA/TAAAAC 4 -- int10--------
    rs757848601,2
    C--216721546(+) ATATAT/AAACAT 4 -- int11Minor allele frequency- A:0.00NA 2
    rs64364561,2
    C,F,A--216724407(+) TTTTTG/TCTTTG 4 -- int1 trp36Minor allele frequency- T:0.38NA WA EA 364
    rs64364571,2
    C,A--216724408(+) TTTTTT/CTTTGT 4 -- int1 trp35Minor allele frequency- C:0.37NA WA EA 362

    HapMap Linkage Disequilibrium report for SERPINE2 (224839765 - 224904036 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SERPINE2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv213199CNV Loss16902084
    nsv875898CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SERPINE2
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 177010    OMIM disorders: --

    Selected diseases for SERPINE2 (see all 36):    
    About MalaCards
    familial encephalopathy with neuroserpin inclusion bodies    brain edema    kartagener syndrome    alpha 1-antitrypsin deficiency
    hepatopulmonary syndrome    primary ciliary dyskinesia    pulmonary emphysema    testicular cancer
    lateral sclerosis    amyotrophic lateral sclerosis    rabies    astrocytoma
    scleroderma    celiac disease    prostate adenocarcinoma    lung cancer susceptibility
    alzheimer's disease    bronchiolitis    oral squamous cell carcinoma    cerebritis

    2 diseases from the University of Copenhagen DISEASES database for SERPINE2:
    Chronic obstructive pulmonary disease     Primary ciliary dyskinesia

    SERPINE2 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for SERPINE2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 34.8 9 10037469 (2), 7846074 (1), 1620346 (1), 2180485 (1) (see all 8)
    senile plaques 27.5 1 1620346 (1)
    astrocytoma 25.1 4 10037469 (2), 11814314 (1), 11939722 (1)
    amyotrophic lateral sclerosis 22.3 1 8549675 (1)
    glioblastoma 9.01 2 7506041 (1), 1987320 (1)
    glioma 7.88 2 8456423 (1), 8940166 (1)
    neurodegeneration 1.23 1 7670362 (1)
    necrosis 0 4 8429047 (2), 11814314 (1), 10228949 (1)
    atrophy 0 1 7846074 (1)
    tumors 0 12 16737540 (4), 8429047 (2), 2037625 (1), 2116223 (1) (see all 6)

    Genetic Association Database (GAD): SERPINE2
    Human Genome Epidemiology (HuGE) Navigator: SERPINE2 (18 documents)

    Export disorders for SERPINE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERPINE2 gene, integrated from 10 sources (see all 165):
    (articles sorted by number of sources associating them with SERPINE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes. (PubMed id 7665170)1, 3, 9 Carter R.E....Festoff B.W. (Genomics 1995)
    2. The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. (PubMed id 17446335)1, 4, 9 Zhu G....Pillai S.G. (Am. J. Respir. Crit. Care Med. 2007)
    3. Genetic associations with hypoxemia and pulmonary arterial pressure in COPD. (PubMed id 19017876)1, 4, 9 Castaldi P.J....Silverman E.K. (Chest 2009)
    4. Polymorphic variation in surfactant protein B is associated with COPD exacerbations. (PubMed id 18550614)1, 4, 9 Foreman M.G....Silverman E.K. (Eur. Respir. J. 2008)
    5. Update of the human and mouse SERPIN gene superfamily. (PubMed id 24172014)1, 3 Heit C....Vasiliou V. (Hum. Genomics 2013)
    6. Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation. (PubMed id 20233420)1, 4 Cho M.H....Silverman E.K. (Respir. Res. 2010)
    7. Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases. (PubMed id 21067581)1, 4 Fujimoto K....Sawabe M. (BMC Med. Genet. 2010)
    8. Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. (PubMed id 19111454)1, 4 Kim W.J....Silverman E.K. (Respir Med 2009)
    9. Absence of association between SERPINE2 genetic polymorphisms and chronic obstructive pulmonary disease in Han Chinese: a case-control cohort study. (PubMed id 19604412)1, 4 Zhong L....Zhang Y.P. (BMC Med. Genet. 2009)
    10. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5270 HGNC: 8951 AceView: SERPINE2 Ensembl:ENSG00000135919 euGenes: HUgn5270
    ECgene: SERPINE2 H-InvDB: SERPINE2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERPINE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERPINE2 gene:
    Search GeneIP for patents involving SERPINE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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