Aliases for SERPINE1 Gene
External Ids for SERPINE1 Gene
Previous HGNC Symbols for SERPINE1 Gene
Previous GeneCards Identifiers for SERPINE1 Gene
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for SERPINE1 Gene
SERPINE1 (Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1) is a Protein Coding gene. Diseases associated with SERPINE1 include plasminogen activator inhibitor-1 deficiency and congenital plasminogen activator inhibitor type 1 deficiency. Among its related pathways are Signaling by GPCR and Hemostasis. GO annotations related to this gene include receptor binding and protease binding. An important paralog of this gene is SERPINB12.
UniProtKB/Swiss-Prot for SERPINE1 Gene
Serine protease inhibitor. This inhibitor acts as bait for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.