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SERPINE1 Gene

protein-coding   GIFtS: 72
GCID: GC07P100770

Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen...

(Previous names: serine (or cysteine) proteinase inhibitor, clade E (nexin,...)
(Previous symbols: PLANH1, PAI1)
  See SERPINE1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator
Inhibitor Type 1), Member 11 2
     PAI2 3
PAI11 2 3 5     PAI-12 3
PLANH11 2 3 5     Plasminogen Activator Inhibitor1
Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen
Activator Inhibitor Type 1), Member 11 2
     Type I1
Endothelial Plasminogen Activator Inhibitor2 3     Plasminogen Activator Inhibitor 12
Serpin E12 3     

External Ids:    HGNC: 85831   Entrez Gene: 50542   Ensembl: ENSG000001063667   OMIM: 1733605   UniProtKB: P051213   

Export aliases for SERPINE1 gene to outside databases

Previous GC identifers: GC07P099254 GC07P100316 GC07P100330 GC07P100363 GC07P100558 GC07P095363


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SERPINE1 Gene:
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal
inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis.
Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high
concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for SERPINE1 Gene:
SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1) is a protein-coding gene. Diseases associated with SERPINE1 include transcription of plasminogen activator inhibitor, modulator of, and central serous chorioretinopathy. GO annotations related to this gene include protease binding and receptor binding. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121
Function: Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase,
protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the
regulation of fibrinolysis

Gene Wiki entry for SERPINE1 (Plasminogen activator inhibitor-1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERPINE1 gene promoter:
         AP-1   AML1a   JunB   AP-2gamma   GATA-2   CREB   HEN1   deltaCREB   SEF-1 (1)   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): SERPINE1 promoter sequence
   Search Chromatin IP Primers for SERPINE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERPINE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

SERPINE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINE1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100770:  view genomic region     (about GC identifiers)

Start:
100,770,370 bp from pter      End:
100,782,547 bp from pter
Size:
12,178 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 100,128,766-100,140,934     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121 (See protein sequence)
Recommended Name: Plasminogen activator inhibitor 1 precursor  
Size: 402 amino acids; 45060 Da
Subunit: Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed
by internalization and degradation
Selected PDB 3D structures from and Proteopedia for SERPINE1 (see all 20):
1A7C (3D)        1B3K (3D)        1C5G (3D)        1DB2 (3D)        1DVM (3D)        1DVN (3D)    
Secondary accessions: B7Z4S0 F8WD53
Alternative splicing: 2 isoforms:  P05121-1   P05121-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SERPINE1: NX_P05121

Explore proteomics data for SERPINE1 at MOPED

Post-translational modifications: 

  • Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-
    -Met-370 bond1
  • Modification sites at neXtProt

  • See SERPINE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000593.1  
    ENSEMBL proteins: 
     ENSP00000223095   ENSP00000396766  
    Reactome Protein details: P05121

    SERPINE1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant SERPINE1 Protein
    R&D Systems Recombinant & Natural Proteins for SERPINE1 (Serpin E1/PAI-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SERPINE1
    OriGene Protein Over-expression Lysate for SERPINE1
    OriGene MassSpec for SERPINE1
    OriGene Custom Protein Services for SERPINE1
    GenScript Custom Purified and Recombinant Proteins Services for SERPINE1
    Novus Biologicals SERPINE1 Proteins
    Novus Biologicals SERPINE1 Lysates
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for SERPINE1
    ProSpec Recombinant Protein for SERPINE1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SERPINE1 

    SERPINE1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SERPINE1
    R&D Systems Antibodies for SERPINE1 (Serpin E1/PAI-1)
    Cell Signaling Technology (CST) Antibodies for SERPINE1 
    OriGene Antibodies for SERPINE1
    OriGene Custom Antibody Services for SERPINE1
    Novus Biologicals SERPINE1 Antibodies
    Abcam antibodies for SERPINE1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for SERPINE1
    LSBio Antibodies in human, mouse, rat for SERPINE1

    SERPINE1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SERPINE1
    R&D Systems ELISAs for SERPINE1 (Serpin E1/PAI-1)         (see first)
    R&D Systems Luminex Assays for SERPINE1 (Serpin E1/PAI-1)
    R&D Systems Proteome Profiler Antibody Arrays for SERPINE1 (Serpin E1/PAI-1)
    See all other biochemical assays at R&D Systems
    GenScript Custom Assay Services for SERPINE1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for SERPINE1:  
                        Human PAI-1 Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Serpin_CS
     IPR000215 Serpin_fam
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry P05121

    ProtoNet protein and cluster: P05121

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121
    Similarity: Belongs to the serpin family


    Find genes that share domains with SERPINE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAI1_HUMAN, P05121
    Function: Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase,
    protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the
    regulation of fibrinolysis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI12114510
    GO:0004867serine-type endopeptidase inhibitor activity IDA1695900
    GO:0005102contributes to receptor binding IPI8626514
    GO:0005515protein binding IPI16272158
         
    Find genes that share ontologies with SERPINE1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERPINE1:
     Decreased melanin production  Increased HPV18 LCR reporter a 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Serpine1):
     adipose tissue  cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  renal/urinary system 
     respiratory system  tumorigenesis 

    Find genes that share phenotypes with SERPINE1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Serpine1tm1Mlg for SERPINE1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERPINE1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SERPINE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERPINE1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SERPINE1:
    hsa-mir-124-3p (MIRT022189), hsa-mir-30c-5p (MIRT005971), hsa-mir-301a-3p (MIRT005972), hsa-mir-145-5p (MIRT006317), hsa-mir-143-3p (MIRT006316), hsa-mir-138-5p (MIRT021688), hsa-mir-99a-5p (MIRT005973), hsa-mir-204-5p (MIRT005844)

    Block miRNA regulation of human, mouse, rat SERPINE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERPINE1 (see all 43):
    hsa-miR-3616-5p hsa-miR-624 hsa-miR-30d hsa-miR-342-3p hsa-miR-449a hsa-miR-30a hsa-miR-642b hsa-miR-3174
    SwitchGear 3'UTR luciferase reporter plasmidSERPINE1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SERPINE1
    Predesigned siRNA for gene silencing in human, mouse, rat SERPINE1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SERPINE1

    Clone
    Products:
         
    OriGene clones in human, mouse for SERPINE1 (see all 13)
    OriGene ORF clones in mouse, rat for SERPINE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SERPINE1 (NM_000602)
    Sino Biological Human cDNA Clone for SERPINE1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINE1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SERPINE1
    ESI BIO PureStem Progenitor for SERPINE1: 
    PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA6-11249) for SERPINE1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAI1_HUMAN, P05121: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytoskeleton2
    nucleus2
    cytosol1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA1695900
    GO:0005886plasma membrane TAS--
    GO:0031012extracellular matrix IDA1632457
    GO:0031093platelet alpha granule lumen TAS--

    Find genes that share ontologies with SERPINE1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SERPINE1 About   (see all 34)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement and Coagulation Cascades0.71
    2Formation of Fibrin Clot (Clotting Cascade)
    Blood Coagulation Signaling Pathways0.51
    Blood Clotting Cascade0.42
    3Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    Signaling by TGF-beta Receptor Complex0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    4Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    5Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66


    Find genes that share SuperPaths with SERPINE1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for SERPINE1
        Blood Coagulation Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SERPINE1
        UPA-UPAR Pathway

    2 Cell Signaling Technology (CST) Pathways for SERPINE1
        Adhesion
    TGF-beta/Smad Signaling

    5 GeneGo (Thomson Reuters) Pathways for SERPINE1
        Cell adhesion PLAU signaling
    Cell adhesion ECM remodeling
    Development TGF-beta receptor signaling
    Development Glucocorticoid receptor signaling
    Immune response IL-1 signaling pathway

    Selected BioSystems Pathways for SERPINE1 (see all 12)
        TGF Beta Signaling Pathway
    Senescence and Autophagy
    Adipogenesis
    Blood Clotting Cascade
    Oncostatin M Signaling Pathway


    5 Reactome Pathways for SERPINE1
        ECM proteoglycans
    Platelet degranulation
    Dissolution of Fibrin Clot
    BMAL1:CLOCK,NPAS2 activates circadian gene expression
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription


    5 Kegg Pathways  (Kegg details for SERPINE1):
        HIF-1 signaling pathway
    p53 signaling pathway
    Hippo signaling pathway
    Complement and coagulation cascades
    Chagas disease (American trypanosomiasis)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SERPINE1 (see all 23): 
              Insulin Signaling Pathway in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Wound Healing in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SERPINE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SERPINE1 (P051211, 2, 3 ENSP000002230954) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ORM1P027631, 3, ENSP000002593964EBI-953978,EBI-976767 I2D: score=3 STRING: ENSP00000259396
    PLATP007502, 3, ENSP000002208094MINT-8309311 I2D: score=3 STRING: ENSP00000220809
    PLAUP007492, 3, ENSP000003618504MINT-8309294 I2D: score=3 STRING: ENSP00000361850
    VTNP040042, 3, ENSP000002262184MINT-24884 I2D: score=4 STRING: ENSP00000226218
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2861504 I2D: score=3 STRING: ENSP00000357292
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001300chronological cell aging IEP18974388
    GO:0001525angiogenesis IEP11866539
    GO:0002576platelet degranulation TAS--
    GO:0006351transcription, DNA-templated TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    Find genes that share ontologies with SERPINE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for SERPINE1
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERPINE1 (PAI1)

    3 HMDB Compounds for SERPINE1    About this table
    CompoundSynonyms CAS #PubMed Ids
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
    Dimethyl sulfoxide(methylsulfinyl)methane;Dimethyl sulfoxide (see all 5)67-68-5--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    7 DrugBank Compounds for SERPINE1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Troglitazone-- 97322-87-7targetantagonist10770198 10418858 10831180 10768100 10871202
    UrokinaseU-plasminogen activator (see all 3)9039-53-6target--12785198 12579271 12745435 12709915 12642587
    Drotrecogin alfaAnticoagulant protein C (see all 4)60202-16-6target--12004248 11259926 14515185 17566522
    Tenecteplaset- PA (see all 4)191588-94-0target--17963464 11163592 14564902
    Alteplaset-PA (see all 4)105857-23-6target--17963464
    Anistreplaset- PA (see all 4)81669-57-0target--17963464
    Reteplaset- PA (see all 4)133652-38-7target--17963464

    Selected Novoseek inferred chemical compound relationships for SERPINE1 gene (see all 130)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 90.2 1414 11770837 (7), 9361687 (6), 9843166 (6), 18948960 (6) (see all 99)
    cholesterol 68.8 409 8475477 (4), 12167171 (3), 20205861 (3), 15260879 (2) (see all 99)
    homocysteine 65.7 248 15994914 (6), 10872824 (5), 16363254 (5), 10365747 (5) (see all 94)
    glucose 64.2 559 17275007 (6), 7519664 (6), 15863881 (6), 16235542 (5) (see all 99)
    serine 63.8 210 12848892 (4), 1901356 (2), 1601844 (2), 7498551 (2) (see all 99)
    metformin 57.3 72 9109854 (5), 11158071 (4), 11953071 (3), 12669266 (3) (see all 34)
    n-867 54.7 1 10634818 (1)
    aprotinin 53.3 32 8857924 (2), 19521296 (2), 9130470 (2), 15668193 (2) (see all 21)
    tgf beta1 51 53 17095240 (6), 11505481 (6), 15268802 (4), 16686283 (3) (see all 20)
    tranexamic acid 51 10 18362590 (3), 8478593 (1), 19521296 (1), 8015955 (1) (see all 7)

    3 PharmGKB related drug/compound annotations for SERPINE1 gene    About this table
    Drug/compound PharmGKB Annotation
    antidepressantsCA  
    citalopramCA  
    fluoxetineCA  



    Find genes that share compounds with SERPINE1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SERPINE1 gene (2 alternative transcripts): 
    NM_000602.4  NM_001165413.2  

    Unigene Cluster for SERPINE1:

    Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    Hs.414795  [show with all ESTs]
    Unigene Representative Sequence: NM_000602
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223095(uc011kkj.2 uc003uxt.3) ENST00000445463(uc003uxu.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SERPINE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERPINE1 (see all 43):
    hsa-miR-3616-5p hsa-miR-624 hsa-miR-30d hsa-miR-342-3p hsa-miR-449a hsa-miR-30a hsa-miR-642b hsa-miR-3174
    SwitchGear 3'UTR luciferase reporter plasmidSERPINE1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SERPINE1
    Predesigned siRNA for gene silencing in human, mouse, rat SERPINE1
    Clone
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    OriGene clones in human, mouse for SERPINE1 (see all 13)
    OriGene ORF clones in mouse, rat for SERPINE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SERPINE1 (NM_000602)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINE1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SERPINE1
    OriGene qSTAR qPCR primer pairs in human, mouse for SERPINE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERPINE1
      QuantiTect SYBR Green Assays in human, mouse, rat SERPINE1
      QuantiFast Probe-based Assays in human, mouse, rat SERPINE1
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA6-11249) for SERPINE1 

    Additional mRNA sequence: 

    AK293248.1 AK297728.1 AK298048.1 AK316225.1 BC010860.1 M14083.1 M16006.1 X04429.1 
    X04731.1 X04744.1 X12701.1 

    Selected DOTS entries (see all 32):

    DT.92398371  DT.95341219  DT.100889494  DT.455508  DT.100889484  DT.100889482  DT.100889505  DT.100044845 
    DT.121059724  DT.91779718  DT.97809442  DT.100889466  DT.75124115  DT.100889507  DT.92050306  DT.95252001 
    DT.120290  DT.121059737  DT.91926506  DT.100889475  DT.100889500  DT.121059641  DT.95252013  DT.100700761 

    21 AceView cDNA sequences:

    CR605271 CR622616 CR605789 CR625802 CR604690 NM_000602 BC020765 CR614829 
    BC005927 BC010860 CR603052 M16006 X04429 M14083 BF107037 X04744 
    X12701 BG565637 X04729 X04731 BX649164 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINE1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
    SP1:                                                                                                
    SP2:                                -     -                                                         
    SP3:        -                                                                                       
    SP4:        -     -     -     -     -                                                               
    SP5:                    -     -     -     -     -     -                                             


    ECgene alternative splicing isoforms for SERPINE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SERPINE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAAATGTT
    SERPINE1 Expression
    About this image


    SERPINE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Line H9 (Naive)
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 3 entries
             Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells
             Placenta-derived mesenchymal stem cells (family)
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
    SERPINE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERPINE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.414795

    UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121
    Tissue specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SERPINE1 (see all 23): 
              Insulin Signaling Pathway in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Wound Healing in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for SERPINE1
    OriGene qSTAR qPCR primer pairs in human, mouse for SERPINE1
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    QuantiFast Probe-based Assays in human, mouse, rat SERPINE1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for SERPINE1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpine11 , 5 serine (or cysteine) peptidase inhibitor, clade E, more1, 5 80.76(n)1
    79.1(a)1
      5 (76.16 cM)5
    187871  NM_008871.21  NP_032897.21 
     1370615045 
    lizard
    (Anolis carolinensis)
    Reptilia SERPINE16
    serpin peptidase inhibitor, clade E (nexin, plasmi...
    66(a)
    1 ↔ 1
    AAWZ02040481(991-6819)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.250942 Xenopus laevis transcribed sequence with weak similarity more 76.56(n)    BJ079964.1 
    zebrafish
    (Danio rerio)
    Actinopterygii serpine11 serpin peptidase inhibitor, clade E (nexin, plasminogen more 56.55(n)
    45.4(a)
      100136840  NM_001114559.1  NP_001108031.1 
    mosquito
    (Anopheles gambiae)
    Insecta SRPN11 SRPN1 46.68(n)
    32.15(a)
      1270171  XM_308847.2  XP_308847.4 


    ENSEMBL Gene Tree for SERPINE1 (if available)
    TreeFam Gene Tree for SERPINE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for SERPINE1 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB32  SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINB112  SERPINE32  
    SERPINB132  SERPINB82  
    Selected SIMAP similar genes for SERPINE1 using alignment to 1 protein entry:     PAI1_HUMAN(see all similar genes):
    SERPINI1    SERPINE2    SERPINC1    SERPINI2    SERPINA1    SERPINA9
    SERPINB4    SERPINA5    SERPINA6    SERPINB3    SERPINB8    SERPINB9
    SERPINA10    SERPINA3    SERPINA4    SERPINB6    SERPINB7    SERPINB11

    Find genes that share paralogs with SERPINE1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SERPINE1 (see all 537)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60921,2,,4
    C,F,Hpathogenic1104137316(+) GCCTGG/ACCCTT 2 /T /A mis1 ese322Minor allele frequency- A:0.09MN NA EA NS EU 9533
    rs361723841,2
    C--95369770(+) TCTCA-/AAAC  
            
    AAACA
    1 -- int11Minor allele frequency- AAAC:0.00CSA 2
    rs2017446521,2
    C--100134393(+) CATTC-/AAAAA 
     AAAAAAA
    AAAAA
    1 -- int10--------
    rs602951751,2
    C--100134414(+) AAAAA-/A/AAAA
    AAAAAAAA
    GGATG
    2 -- int1 cds11NA 2
    rs676516511,2
    C--100138124(+) GAAAG-/AC/C  
      A
    /GAAA
    AAAGA
    1 -- int10--------
    rs58861631,2
    C--100138125(+) AAAGA-/AC/CA 
            
    AAGAA
    1 -- int1 trp30--------
    rs362282731,2
    C--100768755(+) AAAAA-/ACAAAA 1 -- us2k10--------
    rs17997621,2
    C,F--100769706(+) TGGGG-/GAGTCA 1 -- us2k14Minor allele frequency- G:0.47NS NA 282
    rs22276491,2
    C,F--100772243(+) GCTCAAA/-CGCCT 1 -- int12Minor allele frequency- -:0.04NS 92
    rs595022271,2
    C--100772942(+) AGAAA-/AGAA/GAAA/
    GAAACAAAGAAA
    CAAAG
    2 -- int1 cds11NA 2

    HapMap Linkage Disequilibrium report for SERPINE1 (100770370 - 100782547 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SERPINE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    esv2422376CNV Duplication17116639
    nsv831075CNV Loss17160897

    Human Gene Mutation Database (HGMD): SERPINE1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SERPINE1
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 173360   
    OMIM disorders: 613329  
    UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121
  • Plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:613329]: A hematologic disorder characterized
    by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is
    due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which
    inhibits tissue and urinary activators of plasminogen. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial
    occlusions

  • Selected diseases for SERPINE1 (see all 37):    
    About MalaCards
    transcription of plasminogen activator inhibitor, modulator of    central serous chorioretinopathy    plasminogen activator inhibitor type 1 deficiency    carotid artery thrombosis
    meckel's diverticulum    inferior vena cava interruption    chronic angina    amaurosis fugax
    neonatal stroke    hepatic vein thrombosis    proteus syndrome    coronary thrombosis
    paranasal sinus disease    metabolic syndrome x    angiodysplasia    renal fibrosis
    thromboembolism    thrombophilia    retinal artery occlusion    central retinal artery occlusion

    12 diseases from the University of Copenhagen DISEASES database for SERPINE1:
    Heart disease     Diabetes mellitus     Atherosclerosis     Hypertension
    Thrombophilia     Cerebrovascular accident     Kidney disease     Hyperinsulinism
    Hyperglycemia     Lung disease     Hemorrhagic disease     Polycystic ovary syndrome

    Find genes that share disorders with SERPINE1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SERPINE1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 78.2 427 1916049 (5), 11849662 (5), 11719834 (5), 8862693 (4) (see all 99)
    thrombophilia 78 35 14653439 (4), 11525850 (1), 8003387 (1), 8522567 (1) (see all 27)
    thrombosis 76.6 210 8379599 (4), 9631870 (3), 17896948 (3), 15820196 (3) (see all 99)
    cardiovascular diseases 75.2 192 18050673 (3), 9187410 (2), 10695479 (2), 16039281 (2) (see all 99)
    atherosclerosis 72.2 179 14593385 (4), 9187938 (4), 9159836 (3), 10064006 (2) (see all 99)
    venous occlusion 69.3 77 1631786 (6), 12067144 (3), 1783249 (2), 8259554 (2) (see all 43)
    insulin sensitivity 68.3 96 8049187 (6), 9484991 (5), 8104834 (4), 9102176 (3) (see all 54)
    obesity 66.4 305 11816701 (5), 10764686 (5), 16293162 (4), 18175742 (4) (see all 99)
    niddm 64.1 175 8633110 (7), 8822587 (5), 9187410 (4), 9126661 (4) (see all 66)
    hyperinsulinemia 64.1 75 10867719 (2), 8633110 (2), 8036449 (2), 8387542 (2) (see all 46)

    Genetic Association Database (GAD): SERPINE1
    Human Genome Epidemiology (HuGE) Navigator: SERPINE1 (508 documents)

    Export disorders for SERPINE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERPINE1 gene, integrated from 10 sources (see all 3921):
    (articles sorted by number of sources associating them with SERPINE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of human plasminogen activator-inhibitor from endothelial cells. (PubMed id 3097076)1, 2, 3 Ginsburg D.... Gelehrter T.D. (J. Clin. Invest. 1986)
    2. The plasminogen activator inhibitor-1 (PAI-1) promoter haplotype is related to PAI-1 plasma concentrations in lean individuals. (PubMed id 16039281)1, 4, 9 Verschuur M....de Maat M.P. (Atherosclerosis 2005)
    3. Plasminogen activator inhibitor activity, 4G5G polymorphism of the plasminogen activator inhibitor 1 gene, and first-trimester miscarriage in women with polycystic ovary syndrome. (PubMed id 16483878)1, 4, 9 Glueck C.J....Wang P. (Metab. Clin. Exp. 2006)
    4. Plasma PAI-1 levels in obese children--effect of weight loss and influence of PAI-1 promoter 4G/5G genotype. (PubMed id 11522017)1, 4, 9 EstellAcs A....Aznar J. (Thromb. Haemost. 2001)
    5. Investigation of SERPINE1 genetic polymorphism in Macedonian patients with occlusive artery disease and deep vein thrombosis. (PubMed id 20017074)1, 4, 9 Spiroski I....Spiroski M. (Kardiol Pol 2009)
    6. Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene. (PubMed id 9207454)1, 2, 9 Fay W.P.... Shapiro A.D. (Blood 1997)
    7. The -675 4G/5G polymorphism at the Plasminogen Activator Inhibitor 1 (PAI-1) gene modulates plasma Plasminogen Activator Inhibitor 1 concentrations in response to dietary fat consumption. (PubMed id 17903340)1, 4, 9 PAcrez-MartA-nez P....PAcrez-JimAcnez F. (Br. J. Nutr. 2008)
    8. Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. (PubMed id 17119035)1, 4, 9 Sternlicht M.D....Werb Z. (amp 2006)
    9. Plasminogen activator inhibitor-1 and outcome after femoropopliteal angioplasty: analysis of genotype and plasma levels. (PubMed id 14515194)1, 4, 9 Mlekusch W....Wagner O. (Thromb. Haemost. 2003)
    10. Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population. (PubMed id 18953568)1, 4, 9 Schoenhard J.A....Williams S.M. (Hum. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5054 HGNC: 8583 AceView: SERPINE1 Ensembl:ENSG00000106366 euGenes: HUgn5054
    ECgene: SERPINE1 Kegg: 5054 H-InvDB: SERPINE1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SERPINE1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERPINE1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=SERPINE1[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Plasminogen_activator_inhibitor-1
    SeattleSNPshttp://pga.gs.washington.edu/data/serpine1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERPINE1 gene:
    Search GeneIP for patents involving SERPINE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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