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Aliases for SERPINE1 Gene

Aliases for SERPINE1 Gene

  • Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 2 3
  • PAI1 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 2 3
  • Endothelial Plasminogen Activator Inhibitor 3 4
  • Serpin E1 3 4
  • PLANH1 3 4
  • PAI-1 3 4
  • PAI 3 4
  • Plasminogen Activator Inhibitor 1 3
  • Plasminogen Activator Inhibitor 2
  • PLANH1, 6
  • Type I 2

External Ids for SERPINE1 Gene

Previous Symbols for SERPINE1 Gene

  • PLANH1
  • PAI1

Summaries for SERPINE1 Gene

Entrez Gene Summary for SERPINE1 Gene

  • This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for SERPINE1 Gene

SERPINE1 (Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1) is a Protein Coding gene. Diseases associated with SERPINE1 include plasminogen activator inhibitor-1 deficiency and central serous chorioretinopathy. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include receptor binding and protease binding. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINE1 Gene

  • Serine protease inhibitor. This inhibitor acts as bait for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.

Gene Wiki entry for SERPINE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINE1 Gene

Genomics for SERPINE1 Gene

Genomic Location for SERPINE1 Gene

Start:
101,127,089 bp from pter
End:
101,139,266 bp from pter
Size:
12,178 bases
Orientation:
Plus strand

Genomic View for SERPINE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINE1 Gene

Regulatory Elements for SERPINE1 Gene

Proteins for SERPINE1 Gene

  • Protein details for SERPINE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05121-PAI1_HUMAN
    Recommended name:
    Plasminogen activator inhibitor 1
    Protein Accession:
    P05121
    Secondary Accessions:
    • B7Z4S0
    • F8WD53

    Protein attributes for SERPINE1 Gene

    Size:
    402 amino acids
    Molecular mass:
    45060 Da
    Quaternary structure:
    • Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation.

    Three dimensional structures from OCA and Proteopedia for SERPINE1 Gene

    Alternative splice isoforms for SERPINE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINE1 Gene

Proteomics data for SERPINE1 Gene at MOPED

Post-translational modifications for SERPINE1 Gene

  • Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg- -Met-370 bond

Other Protein References for SERPINE1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINE1 Gene

Domains for SERPINE1 Gene

Gene Families for SERPINE1 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINE1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PAI1_HUMAN
Family:
  • Belongs to the serpin family.:
    • P05121
genes like me logo Genes that share domains with SERPINE1: view

Function for SERPINE1 Gene

Molecular function for SERPINE1 Gene

UniProtKB/Swiss-Prot Function: Serine protease inhibitor. This inhibitor acts as bait for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.

Gene Ontology (GO) - Molecular Function for SERPINE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 12114510
GO:0004867 serine-type endopeptidase inhibitor activity IDA 1695900
GO:0005102 receptor binding IPI 8626514
GO:0005515 protein binding IPI 16272158
genes like me logo Genes that share ontologies with SERPINE1: view
genes like me logo Genes that share phenotypes with SERPINE1: view

Animal Models for SERPINE1 Gene

MGI Knock Outs for SERPINE1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SERPINE1 Gene

Localization for SERPINE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINE1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINE1 Gene COMPARTMENTS Subcellular localization image for SERPINE1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2
nucleus 2
cytosol 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SERPINE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 1695900
GO:0005886 plasma membrane TAS --
GO:0031012 extracellular matrix IDA 1632457
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with SERPINE1: view

Pathways for SERPINE1 Gene

genes like me logo Genes that share pathways with SERPINE1: view

Gene Ontology (GO) - Biological Process for SERPINE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001300 chronological cell aging IEP 18974388
GO:0001525 angiogenesis IEP 11866539
GO:0002576 platelet degranulation TAS --
GO:0006351 transcription, DNA-templated TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with SERPINE1: view

Compounds for SERPINE1 Gene

(3) HMDB Compounds for SERPINE1 Gene

Compound Synonyms Cas Number PubMed IDs
Atorvastatin
  • Atorvastatin acid
134523-00-5
Dimethyl sulfoxide
  • (methylsulfinyl)methane
67-68-5
Simvastatin
  • (+)-Simvastatin
79902-63-9

(7) Drugbank Compounds for SERPINE1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alteplase
  • t-PA
105857-23-6 target
Anistreplase
  • t- PA
81669-57-0 target
Drotrecogin alfa
  • Anticoagulant protein C
60202-16-6 target
Reteplase
  • t- PA
133652-38-7 target
Tenecteplase
  • t- PA
191588-94-0 target

(130) Novoseek inferred chemical compound relationships for SERPINE1 Gene

Compound -log(P) Hits PubMed IDs
fibrinogen 90.2 319
cholesterol 68.8 118
homocysteine 65.7 142
glucose 64.2 205
serine 63.8 112

(3) PharmGKB related drug/compound annotations for SERPINE1 Gene

Drug/compound Annotation
antidepressants CA
citalopram CA
fluoxetine CA
genes like me logo Genes that share compounds with SERPINE1: view

Transcripts for SERPINE1 Gene

mRNA/cDNA for SERPINE1 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINE1 Gene

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINE1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
SP1:
SP2: - -
SP3: -
SP4: - - - - -
SP5: - - - - - -

Relevant External Links for SERPINE1 Gene

GeneLoc Exon Structure for
SERPINE1
ECgene alternative splicing isoforms for
SERPINE1

Expression for SERPINE1 Gene

mRNA expression in normal human tissues for SERPINE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINE1 Gene

This gene is overexpressed in Artery - Aorta (8.2), Artery - Coronary (6.6), and Liver (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERPINE1 Gene

SOURCE GeneReport for Unigene cluster for SERPINE1 Gene Hs.414795

mRNA Expression by UniProt/SwissProt for SERPINE1 Gene

P05121-PAI1_HUMAN
Tissue specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells
genes like me logo Genes that share expressions with SERPINE1: view

Orthologs for SERPINE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINE1 36
  • 99.83 (n)
  • 99.5 (a)
SERPINE1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINE1 36
  • 86.48 (n)
  • 85.32 (a)
SERPINE1 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAI-1 37
  • 86 (a)
OneToOne
SERPINE1 36
  • 85.32 (n)
  • 86.07 (a)
mouse
(Mus musculus)
Mammalia Serpine1 36
  • 80.76 (n)
  • 79.1 (a)
Serpine1 16
Serpine1 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERPINE1 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpine1 36
  • 81.51 (n)
  • 80.85 (a)
lizard
(Anolis carolinensis)
Reptilia SERPINE1 37
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25094 36
tropical clawed frog
(Silurana tropicalis)
Amphibia serpine1 36
  • 57.98 (n)
  • 51.88 (a)
zebrafish
(Danio rerio)
Actinopterygii serpine1 36
  • 56.55 (n)
  • 45.4 (a)
serpine1 37
  • 42 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta SRPN1 36
  • 46.68 (n)
  • 32.15 (a)
Species with no ortholog for SERPINE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINE1 Gene

ENSEMBL:
Gene Tree for SERPINE1 (if available)
TreeFam:
Gene Tree for SERPINE1 (if available)

Paralogs for SERPINE1 Gene

genes like me logo Genes that share paralogs with SERPINE1: view

Variants for SERPINE1 Gene

Sequence variations from dbSNP and Humsavar for SERPINE1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs6089 -- 101,137,104(+) CATCA(C/T)GTTCC intron-variant
rs6090 - 101,128,442(+) CCCTT(A/G)TCTTT missense, reference
rs6091 -- 101,130,506(+) GACGC(A/G)ATCTT synonymous-codon, reference
rs6092 Pathogenic, - 101,128,436(+) GCCTG(A/G)CCCTT missense, reference
rs7241 -- 101,138,132(+) NTGCT(C/T)CCTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SERPINE1 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831075 CNV Loss 17160897
esv2422376 CNV Duplication 17116639

Relevant External Links for SERPINE1 Gene

HapMap Linkage Disequilibrium report
SERPINE1
Human Gene Mutation Database (HGMD)
SERPINE1

Disorders for SERPINE1 Gene

(1) OMIM Diseases for SERPINE1 Gene (173360)

UniProtKB/Swiss-Prot

PAI1_HUMAN
  • Plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:613329]: A hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen. {ECO:0000269 PubMed:9207454}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.

(95) Novoseek inferred disease relationships for SERPINE1 Gene

Disease -log(P) Hits PubMed IDs
insulin resistance 78.2 190
thrombophilia 78 30
thrombosis 76.6 114
cardiovascular diseases 75.2 113
atherosclerosis 72.2 116

Relevant External Links for SERPINE1

Genetic Association Database (GAD)
SERPINE1
Human Genome Epidemiology (HuGE) Navigator
SERPINE1
genes like me logo Genes that share disorders with SERPINE1: view

Publications for SERPINE1 Gene

  1. Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1. (PMID: 7552714) Aertgeerts K. … Declerck P.J. (Nat. Struct. Biol. 1995) 3 4 23
  2. Identification of a PAI-1 binding site in vitronectin. (PMID: 7522053) Sigurdardottir O. … Wiman B. (Biochim. Biophys. Acta 1994) 3 4 23
  3. Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction. (PMID: 7892190) Eriksson P. … Hamsten A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 23 49
  4. Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide. (PMID: 9634700) Xue Y. … Deinum J. (Structure 1998) 3 4 23
  5. The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion. (PMID: 10368279) Sharp A.M. … Read R.J. (Structure 1999) 3 4 23

Products for SERPINE1 Gene

Sources for SERPINE1 Gene

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