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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SERPINE1 Gene

protein-coding GIFtS: 74
GCID: GC07P100770

serpin peptidase inhibitor, clade E (nexin, plasminogen...

(Previous names: serine (or cysteine) proteinase inhibitor, clade E (nexin,...)
(Previous symbols: PLANH1, PAI1)

Explore 299 diseases affiliated with
SERPINE1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1¹ ²		Endothelial Plasminogen Activator Inhibitor² ³
PAI1¹ ² ³ ⁵		Serpin E1² ³
PLANH1¹ ² ³ ⁵		PAI-1² ³
PAI¹ ² ³		Plasminogen Activator Inhibitor 1²
Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1¹ ²

External Ids:	HGNC: 8583¹	Entrez Gene: 5054²	Ensembl: ENSG00000106366⁷	OMIM: 173360⁵	UniProtKB: P05121³

Export aliases for SERPINE1 gene to outside databases

Previous GC identifers: GC07P099254 GC07P100316 GC07P100330 GC07P100363 GC07P100558 GC07P095363

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SERPINE1:

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal

inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis.

Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high

concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants

encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121

Function: Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein

C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of

fibrinolysis

Gene Wiki entry for SERPINE1 (Plasminogen activator inhibitor-1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SERPINE1 gene promoter:
AP-1 AML1a JunB AP-2gamma GATA-2 CREB HEN1 deltaCREB SEF-1 (1) ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): SERPINE1 promoter sequence

Search SABiosciences Chromatin IP Primers for SERPINE1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINE1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1

SERPINE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINE1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P100770: view genomic region (about GC identifiers)

Start:	100,770,370 bp from pter	End:	100,782,547 bp from pter
Size:	12,178 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 100,128,766-100,140,934

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121 (See protein sequence)

Recommended Name: Plasminogen activator inhibitor 1 precursor

Size: 402 amino acids; 45060 Da

Subunit: Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by

internalization and degradation

Subcellular location: Secreted

6/17 PDB 3D structures from and Proteopedia for SERPINE1 (see all 17):

1A7C (3D)

1B3K (3D)

1C5G (3D)

1DB2 (3D)

1DVM (3D)

1DVN (3D)

Secondary accessions: B7Z4S0 F8WD53

Alternative splicing: 2 isoforms: P05121-1 P05121-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SERPINE1: NX_P05121

Post-translational modifications:

Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-

-Met-370 bond¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05121

SERPINE1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000593.1 NP_001158885.1

ENSEMBL proteins:

ENSP00000223095 ENSP00000392435 ENSP00000396766

Reactome Protein details: P05121
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant SERPINE1 Protein
	R&D Systems Recombinant & Natural Proteins for SERPINE1 (Serpin E1/PAI-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SERPINE1 OriGene Protein Over-expression Lysate (see all 2): SERPINE1 OriGene Custom Protein Services for SERPINE1
	GenScript Custom Purified and Recombinant Proteins Services for SERPINE1
	Novus Biologicals SERPINE1 Proteins Novus Biologicals SERPINE1 Lysates
	Sino Biological Recombinant Protein for SERPINE1
	ProSpec Recombinant Protein for SERPINE1
	Uscn Proteins for SERPINE1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	18835034
GO:0005625	soluble fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0031012	extracellular matrix	IDA	1632457

SERPINE1 for ontologies About GeneDecksing

SERPINE1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SERPINE1
	R&D Systems Antibodies for SERPINE1 (Serpin E1/PAI-1)
	Cell Signaling Technology (CST) Antibodies for SERPINE1
	OriGene Antibodies (see all 2): SERPINE1 OriGene Custom Antibody Services for SERPINE1
	GenScript Custom Superior Antibodies Services for SERPINE1
	Novus Biologicals SERPINE1 Antibodies
	Abcam antibodies for SERPINE1
	Uscn Antibodies for SERPINE1
	ThermoFisher Antibodies for SERPINE1

Assay Products for SERPINE1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for SERPINE1 (Serpin E1/PAI-1) (see all)
	GenScript Custom Assay Services for SERPINE1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SERPINE1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SERPINE1 for domains About GeneDecksing

3 InterPro domains/families:

IPR023795 Protease_inhib_I4_serpin_CS

IPR023796 Serpin_dom

IPR000215 Serpin_fam

Graphical View of Domain Structure for InterPro Entry P05121

ProtoNet protein and cluster: P05121

1 Blocks protein family: IPB000215 Serpin

UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121

Similarity: Belongs to the serpin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121

Function: Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein

C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of

fibrinolysis

miRNA Products:		miRTarBase miRNAs that target SERPINE1: hsa-mir-99a (MIRT005973), hsa-mir-30c (MIRT005971), hsa-mir-204 (MIRT005844), hsa-mir-301a (MIRT005972)

		OriGene 3'-UTR Clone (see all 2): SERPINE1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINE1
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINE1 (see all 43):
		hsa-miR-3616-5p hsa-miR-624 hsa-miR-30d hsa-miR-342-3p hsa-miR-449a hsa-miR-30a hsa-miR-642b hsa-miR-3174

		SwitchGear 3'UTR luciferase reporter plasmid: SERPINE1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINE1 (see all 7) OriGene shRNA RFP: SERPINE1 OriGene siRNA: SERPINE1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINE1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SERPINE1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINE1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINE1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SERPINE1 (NM_000602)
		Sino Biological Human cDNA Clone for SERPINE1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINE1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINE1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SERPINE1
		LifeMap BioReagents: cell line associated with SERPINE1: PureStem ES-210, Ecto-ntu Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IPI	8626514
GO:0004867	serine-type endopeptidase inhibitor activity	IPI	8508955
GO:0005102	contributes to receptor binding	IPI	8626514
GO:0005515	protein binding	IPI	16272158

SERPINE1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SERPINE1:

Decreased melanin production

Increased HPV18 LCR reporter a

Animal Models:
Mouse knock-out Serpine1^tm1Mlg for SERPINE1
12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Serpine1):

adipose tissue	cardiovascular system	growth/size	hematopoietic system	homeostasis/metabolism
immune system	integument	liver/biliary system	mortality/aging	renal/urinary system
respiratory system	tumorigenesis

SERPINE1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Expression of PAI-1

	Expression of PAI-1	1.00			Dissolution of Fibrin Clot	0.10
	WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it	1.00

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	1.00			Signaling by TGF-beta Receptor Complex	0.61
	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.63

Immune response_IL-1 signaling pathway

Immune response_IL-1 signaling pathway

1.00

Immune response IL-1 signaling pathway

0.98

Development_TGF-beta receptor signaling

Development_TGF-beta receptor signaling

1.00

Development TGF-beta receptor signaling

0.96

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for SERPINE1

	Development Glucocorticoid receptor signaling
	Cell adhesion PLAU signaling
	Cell adhesion ECM remodeling
	Development TGF-beta receptor signaling
	Immune response IL-1 signaling pathway

1 R&D Systems Pathway for SERPINE1

Blood Coagulation Signaling Pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SERPINE1

UPA-UPAR Pathway

2 Cell Signaling Technology (CST) Pathways for SERPINE1

	Adhesion
	TGF-beta/Smad Signaling

5 GeneGo (Thomson Reuters) Pathways for SERPINE1

	Cell adhesion PLAU signaling
	Cell adhesion ECM remodeling
	Development TGF-beta receptor signaling
	Development Glucocorticoid receptor signaling
	Immune response IL-1 signaling pathway

5/12 BioSystems Pathways for SERPINE1 (see all 12)

	TGF Beta Signaling Pathway
	Blood Clotting Cascade
	Oncostatin M Signaling Pathway
	Senescence and Autophagy
	Adipogenesis

5/15 Reactome Pathways for SERPINE1 (see all 15)

	Hemostasis
	Circadian Clock
	Generic Transcription Pathway
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Response to elevated platelet cytosolic Ca2+

3 Kegg Pathways (Kegg details for SERPINE1):

	p53 signaling pathway
	Complement and coagulation cascades
	Chagas disease (American trypanosomiasis)

SERPINE1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SERPINE1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/75 Interacting proteins for SERPINE1 (P05121^{1, 2, 3} ENSP00000223095⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 75)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ORM1	P02763¹^,³, ENSP00000259396⁴	EBI-953978,EBI-976767 I2D: score=3 STRING: ENSP00000259396
PLAT	P00750²^,³, ENSP00000220809⁴	MINT-8309311 I2D: score=3 STRING: ENSP00000220809
PLAU	P00749²^,³, ENSP00000361850⁴	MINT-8309294 I2D: score=3 STRING: ENSP00000361850
VTN	P04004²^,³, ENSP00000226218⁴	MINT-24884 I2D: score=4 STRING: ENSP00000226218
UBQLN4	Q9NRR5²^,³, ENSP00000357292⁴	MINT-2861504 I2D: score=3 STRING: ENSP00000357292

About this table

Gene Ontology (GO): 5/45 biological process terms (GO ID links to tree view) (see all 45): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000302	response to reactive oxygen species	--	--
GO:0001300	chronological cell aging	IEP	18974388
GO:0001525	angiogenesis	IEP	11866539
GO:0002576	platelet degranulation	TAS	--
GO:0006351	transcription, DNA-dependent	TAS	--

SERPINE1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SERPINE1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for SERPINE1

Browse Tocris compounds for SERPINE1

3 HMDB Compounds for SERPINE1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Atorvastatin	Atorvastatin acid (see all 4)	134523-00-5	--
Dimethyl sulfoxide	(methylsulfinyl)methane;Dimethyl sulfoxide (see all 5)	67-68-5	--
Simvastatin	(+)-Simvastatin (see all 28)	79902-63-9	--

7 DrugBank Compounds for SERPINE1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Troglitazone	--	97322-87-7	target	antagonist	10770198 10418858 10831180 10768100 10871202
Urokinase	U-plasminogen activator (see all 3)	9039-53-6	target	--	12785198 12579271 12745435 12709915 12642587
Drotrecogin alfa	Anticoagulant protein C (see all 4)	60202-16-6	target	--	12004248 11259926 14515185 17566522
Tenecteplase	t- PA (see all 4)	191588-94-0	target	--	17963464 11163592 14564902
Alteplase	t-PA (see all 4)	105857-23-6	target	--	17963464
Anistreplase	t- PA (see all 4)	81669-57-0	target	--	17963464
Reteplase	t- PA (see all 4)	133652-38-7	target	--	17963464

10/130 Novoseek chemical compound relationships for SERPINE1 gene (see all 130) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	90.2	1414	11770837 (7), 9361687 (6), 9843166 (6), 18948960 (6) (see all 99)
cholesterol	68.8	409	8475477 (4), 12167171 (3), 20205861 (3), 15260879 (2) (see all 99)
homocysteine	65.7	248	15994914 (6), 10872824 (5), 16363254 (5), 10365747 (5) (see all 94)
glucose	64.2	559	17275007 (6), 7519664 (6), 15863881 (6), 16235542 (5) (see all 99)
serine	63.8	210	12848892 (4), 1901356 (2), 1601844 (2), 7498551 (2) (see all 99)
metformin	57.3	72	9109854 (5), 11158071 (4), 11953071 (3), 12669266 (3) (see all 34)
n-867	54.7	1	10634818 (1)
aprotinin	53.3	32	8857924 (2), 19521296 (2), 9130470 (2), 15668193 (2) (see all 21)
tgf beta1	51	53	17095240 (6), 11505481 (6), 15268802 (4), 16686283 (3) (see all 20)
tranexamic acid	51	10	18362590 (3), 8478593 (1), 19521296 (1), 8015955 (1) (see all 7)

3 PharmGKB related drug/compound annotations for SERPINE1 gene

Drug/compound	PharmGKB Annotation
antidepressants	CA
citalopram	CA
fluoxetine	CA

About this table

Search CenterWatch for drugs/clinical trials and news about SERPINE1 / PAI1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SERPINE1 gene (2 alternative transcripts):

NM_000602.4 NM_001165413.2

Unigene Clusters for SERPINE1:

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Hs.414795 [show with all ESTs], Hs.741440 [show with all ESTs]

Unigene Representative Sequences: NM_000602, BQ218834

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000223095(uc011kkj.2 uc003uxt.3) ENST00000441467 ENST00000445463(uc003uxu.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SERPINE1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINE1
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINE1 (see all 43):
		hsa-miR-3616-5p hsa-miR-624 hsa-miR-30d hsa-miR-342-3p hsa-miR-449a hsa-miR-30a hsa-miR-642b hsa-miR-3174

		SwitchGear 3'UTR luciferase reporter plasmid: SERPINE1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINE1 (see all 7) OriGene shRNA RFP: SERPINE1 OriGene siRNA: SERPINE1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINE1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINE1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINE1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SERPINE1 (NM_000602)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINE1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINE1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINE1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SERPINE1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINE1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINE1

Additional cDNA sequence: X04729.1

24/33 DOTS entries (see all 33):

DT.92398371 DT.95341219 DT.100889494 DT.455508 DT.100889484 DT.100889482 DT.100889505 DT.100044845

DT.121059724 DT.91779718 DT.97809442 DT.100889466 DT.75124115 DT.100889507 DT.92050306 DT.95252001

DT.120290 DT.121059737 DT.91926506 DT.100889475 DT.100889500 DT.121059641 DT.95252013 DT.97768277

21 AceView cDNA sequences:

CR604690 CR625802 CR605271 CR605789 NM_000602 CR603052 CR622616 M16006

BC020765 BC005927 CR614829 BC010860 M14083 X04744 X04429 X12701

BF107037 BG565637 X04729 X04731 BX649164

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINE1 About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8	^	9
SP1:
SP2:											-		-
SP3:			-
SP4:			-		-		-		-		-
SP5:							-		-		-		-		-		-

ECgene alternative splicing isoforms for SERPINE1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SERPINE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAAATGTT

About this image

SERPINE1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Mural Cells

Extraembryonic Tissues

Lateral Plate Mesoderm

Splanchnic Mesoderm

Mural Cells

Pericytes, Smooth Muscle

Placenta

Chorionic Villus

Villous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Placenta

Extravillous Cytotrophoblast Layer

Extravillous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Epicardium

Respiratory Bronchioles

Basal Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

Line H7 (WA07) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Adult human kidney epithelial cells (Primary Cell)

Kidney

See SERPINE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SERPINE1

SOURCE GeneReport for Unigene clusters: Hs.414795 Hs.741440

UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121

Tissue specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells

SABiosciences Expression via Pathway-Focused PCR Arrays including SERPINE1 (see all 23):

Insulin Signaling Pathway in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Wound Healing in human mouse rat

Hypoxia Signaling Pathway in human mouse rat

Stress & Toxicity PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINE1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SERPINE1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINE1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINE1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERPINE1 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	SERPINE1⁶	--	66(a)	1 ↔ 1	AAWZ02040481(991-5619)
African clawed frog (Xenopus laevis)	Amphibia	Xl.25094²	Xenopus laevis transcribed sequence with weak similarity more	76.56(n)		BJ079964.1
zebrafish (Danio rerio)	Actinopterygii	serpine1¹	serpin peptidase inhibitor, clade E (nexin, plasminogen more	56.55(n) 45.4(a)		100136840 NM_001114559.1 NP_001108031.1
fruit fly (Drosophila melanogaster)	Insecta	Spn1⁶ Spn6⁶ (see all 26)	Serine protease inhibitor 6 (see all 26)	26(a) 25(a) (see all 26)	possible ortholog possible ortholog (see all 26)	2R(2770786-2772378) 2R(14013810-14015715)
worm (Caenorhabditis elegans)	Secernentea	srp-7⁶ srp-6⁶ (see all 6)	SeRPin family member (srp-6) (see all 6)	23(a) 22(a) (see all 6)	possible ortholog possible ortholog (see all 6)	V(8179111-8183422) V(7384214-7386288)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G64010⁶ AT2G25240⁶ (see all 10)	serpin-Z10 (see all 10)	26(a) 25(a) (see all 10)	many ↔ many many ↔ many (see all 10)	1(23750884-23751441) 2(10751768-10753134)
rice (Oryza sativa)	Liliopsida	-- -- (see all 16)	serpin domain containing protein, putative serpin domain containing protein, putative, expres... (see all 16)	25(a) 25(a) (see all 16)	many ↔ many many ↔ many (see all 16)	11(6958994-6960308) 1(32248927-32250581)

ENSEMBL Gene Tree for SERPINE1 (if available)
TreeFam Gene Tree for SERPINE1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SERPINE1 gene

SERPINB7² SERPINB1² SERPINI1² SERPINB5² SERPINB12² SERPINI2² SERPINB2² SERPINB10²

SERPINB3² SERPINB4² SERPINE2² SERPINB6² SERPINC1² SERPINB9² SERPINE3² SERPINB13²

SERPINB8²

18/26 SIMAP similar genes for SERPINE1 using alignment to 2 protein entries: PAI1_HUMAN (see all proteins) (see all similar genes):

SERPINI1 SERPINE2 SERPINC1 SERPINI2 SERPINA1 SERPINA9

SERPINB4 SERPINA5 SERPINA6 SERPINB3 SERPINB8 SERPINB9

SERPINA10 SERPINA3 SERPINA4 SERPINB6 SERPINB7 SERPINB11

SERPINE1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6092^1,2	C,F,H,	pathogenic	100130104(+)	`GCCTGG/ACCCTT`	4	/T /A	mis¹ ese³		22		MN NA EA NS EU	9533
rs36228614^1,2	C,	--	100126816(+)	`CACACG/AGCCAA`	2	--	us2k¹		1		NA	2
rs36228272^1,2	C,	--	100126987(+)	`TTAGCC/TGGGCG`	2	--	us2k¹		0	--	--	--	--
rs2227629^1,2	C	--	100127361(+)	`TCACTC/TGCATT`	2	--	us2k¹		2		NS	94
rs2227630^1,2	C,F,	--	100127447(+)	`TGTTCA/TTGTGA`	2	--	us2k¹		3		NS WA	212
rs2227707^1,2	C,F,	--	100127673(+)	`CATCCC/TGAAAC`	2	--	us2k¹		3		NS NA	214
rs77874694^1,2	F,	--	100127770(+)	`CTATCG/AGTCAC`	2	--	us2k¹		1		NA	120
rs200945016^1,2	C	--	100128233(+)	`GGCTGG/TTGGGC`	2	--	us2k¹		0	--	--	--	--
rs2227632^1,2	C,F,H,	--	100128262(+)	`GGGGCG/ACTCTT`	2	--	us2k¹		9		NS EA NA CSA WA	630
rs33997895^1,2	C,	--	100128674(+)	`CAGACG/AGACTC`	2	--	us2k¹		2		NA	4

HapMap Linkage Disequilibrium report for SERPINE1 (100770370 - 100782547 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SERPINE1
1 CNV: 5245
Human Gene Mutation Database (HGMD): SERPINE1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINE1

DNA2.0 Custom Variant and Variant Library Synthesis for SERPINE1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SERPINE1 for disorders           About GeneDecksing

OMIM gene information: 173360
OMIM disorders: 613329
UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121

Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:613329]. It is

a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have

menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of

plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen

Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial

occlusions

20/299 diseases for SERPINE1 (see all 299): About MalaCards

transcription of plasminogen activator inhibitor, modulator of legg-calve-perthes disease plasminogen activator inhibitor type 1 deficiency carotid intimal medial thickness

thrombophilia open-angle glaucoma disseminated intravascular coagulation familial encephalopathy with neuroserpin inclusion bodies

severe pre-eclampsia heparin-induced thrombocytopenia deep vein thrombosis alpha 1-antitrypsin deficiency

pre-eclampsia spinal cord injury central serous chorioretinopathy carotid artery thrombosis

plasminogen activator deficiency retinal vein occlusion central retinal vein occlusion primary open angle glaucoma

11 diseases from the University of Copenhagen DISEASES database for SERPINE1:

Heart disease Diabetes mellitus Atherosclerosis Hypertension

Cerebrovascular accident Disseminated intravascular coagulation Kidney disease Hyperinsulinism

Hyperglycemia Lung disease Polycystic ovary syndrome

10/95 Novoseek disease relationships for SERPINE1 gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
insulin resistance	78.2	427	1916049 (5), 11849662 (5), 11719834 (5), 8862693 (4) (see all 99)
thrombophilia	78	35	14653439 (4), 11525850 (1), 8003387 (1), 8522567 (1) (see all 27)
thrombosis	76.6	210	8379599 (4), 9631870 (3), 17896948 (3), 15820196 (3) (see all 99)
cardiovascular diseases	75.2	192	18050673 (3), 9187410 (2), 10695479 (2), 16039281 (2) (see all 99)
atherosclerosis	72.2	179	14593385 (4), 9187938 (4), 9159836 (3), 10064006 (2) (see all 99)
venous occlusion	69.3	77	1631786 (6), 12067144 (3), 1783249 (2), 8259554 (2) (see all 43)
insulin sensitivity	68.3	96	8049187 (6), 9484991 (5), 8104834 (4), 9102176 (3) (see all 54)
obesity	66.4	305	11816701 (5), 10764686 (5), 16293162 (4), 18175742 (4) (see all 99)
niddm	64.1	175	8633110 (7), 8822587 (5), 9187410 (4), 9126661 (4) (see all 66)
hyperinsulinemia	64.1	75	10867719 (2), 8633110 (2), 8036449 (2), 8387542 (2) (see all 46)

Genetic Association Database (GAD): SERPINE1
Human Genome Epidemiology (HuGE) Navigator: SERPINE1 (508 documents)

Export disorders for SERPINE1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SERPINE1 gene, integrated from 9 sources (see all 3860):
(articles sorted by number of sources associating them with SERPINE1)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning of human plasminogen activator-inhibitor from endothelial cells. (PubMed id 3097076)^{1, 2, 3} Ginsburg D.... Gelehrter T.D. (1986)
The plasminogen activator inhibitor-1 (PAI-1) promoter haplotype is related to PAI-1 plasma concentrations in lean individuals. (PubMed id 16039281)^{1, 4, 9} Verschuur M....de Maat M.P. (2005)
Plasma PAI-1 levels in obese children--effect of weight loss and influence of PAI-1 promoter 4G/5G genotype. (PubMed id 11522017)^{1, 4, 9} Estelles A....Aznar J. (2001)
Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene. (PubMed id 9207454)^{1, 2, 9} Fay W.P....Shapiro A.D. (1997)
Plasminogen activator inhibitor-1 and outcome after femoropopliteal angioplasty: analysis of genotype and plasma levels. (PubMed id 14515194)^{1, 4, 9} Mlekusch W....Wagner O. (2003)
PAI-1 and homocysteine, but not lipoprotein (a) and thrombophilic polymorphisms, are independently associated with the occurrence of major adverse cardiac events after successful coronary stenting. (PubMed id 15994914)^{1, 4, 9} Marcucci R....Gensini G.F. (2006)
Tissue plasminogen activator and plasminogen activator inhibitor type 1 gene polymorphism in patients with gastric ulcer complicated with bleeding. (PubMed id 12589088)^{1, 4, 9} Kim H.S....Hong S.Y. (2003)
Elevated plasma activator inhibitor 1 is not related to insulin resistance and to gene polymorphism in healthy centenarians. (PubMed id 11849662)^{1, 4, 9} Rizzo M.R....Paolisso G. (2002)
Plasminogen activator inhibitor-1 4G/5G polymorphism in breast cancer patients and its association with tissue PAI-1 levels and tumor severity. (PubMed id 15907980)^{1, 4, 9} Castello R....Estelles A. (2006)
The PAI-1 gene 4G/5G polymorphism and deep vein thrombosis in patients with inherited thrombophilia. (PubMed id 14653439)^{1, 4, 9} Sartori M.T....Girolami A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5054	HGNC: 8583	AceView: SERPINE1	Ensembl:ENSG00000106366	euGenes: HUgn5054
ECgene: SERPINE1	Kegg: 5054	H-InvDB: SERPINE1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SERPINE1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SERPINE1	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SERPINE1
Wikipedia	http://en.wikipedia.org/wiki/Plasminogen_activator_inhibitor-1
SeattleSNPs	http://pga.gs.washington.edu/data/serpine1/

Intellectual Property for SERPINE1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SERPINE1 gene:
Search GeneIP for patents involving SERPINE1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Advanced Cell Diagnostics
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Cell Line associated with SERPINE1: PureStem ES-210, Ecto-ntu Progenitor

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PT PROLONGED
Fatty Liver
Hepatic Veno-Occlusive Disease
Microalbuminuria
Hyperinsulinemia
essential hypertension
sepsis
veno-occlusive disease
Peripheral Vascular Diseases
coagulopathy
Acute myocardial infarction
Hyperlipidemia
Glucose Intolerance
Hypertriglyceridemias Familial
insulin sensitivity
stage ovarian cancer
Myocardial Ischemia
Atherosclerosis
Purpura Thrombotic Thrombocytopenic
Breast Cancer
Deep vein thrombosis
Hypercholesterolemia
Hypofibrinogenemia
cell damage
Cancer
Coronary Atherosclerosis
Dyslipidemia
RENAL DISEASE
Cerebral Infarction
ARTERIAL THROMBOSIS
Protein C Deficiency
FIBRINOLYTIC DEFECT
Inflammation
glomerulosclerosis
Diabetic Nephropathies
Coronary Thrombosis
Hyperhomocysteinemia
Hyperglycemia
Severe pre-eclampsia
Tumors
Cardiovascular Diseases
HELLP Syndrome
Metastasis
Thrombosis
Necrosis
Fibrosarcoma
metabolic disorder
Carotid Atherosclerosis
Preeclampsia
Disseminated Intravascular Coagulation
Coronary Heart Disease
Shock Septic
BREAST CARCINOMA
APC Resistance
Pulmonary Fibrosis
OVARIAN TUMOR BENIGN
Chronic glomerulonephritis
Venous Thrombosis
Liver Fibrosis
atherosclerotic plaque
Carotid Artery Thrombosis
Systemic Inflammatory Response Syndrome
retinopathy
Diabetes Mellitus
Renal fibrosis
Hyperlipoproteinemia
VENOUS OCCLUSION
Diabetic Retinopathy
BLEEDING TENDENCY
Arteriosclerosis
Metabolic Syndrome X
Myocardial Infarction
Albuminuria
Multiple Organ Failure
Coronary Artery Disease
Response Acute Phase
Insulin Resistance
impaired glucose tolerance
Protein S Deficiency
stasis
Bleeding
Keloid
Hypertriglyceridemia
Thromboembolism Pulmonary
OBESITY
Polycystic Ovary Syndrome
restenosis
STROKE
Thrombophilia
Vascular Diseases
reactive hyperemia
Syndrome X
NIDDM
Peritoneal Adhesions
Thromboembolism

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SERPINE1 Gene

serpin peptidase inhibitor, clade E (nexin, plasminogen...

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