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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINE1 Gene

protein-coding   GIFtS: 73
GCID: GC07P100770

Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen...

(Previous names: serine (or cysteine) proteinase inhibitor, clade E (nexin,...)
(Previous symbols: PLANH1, PAI1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator
Inhibitor Type 1), Member 11 2
     PAI2 3
PAI11 2 3 5     PAI-12 3
PLANH11 2 3 5     Plasminogen Activator Inhibitor1
Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen
Activator Inhibitor Type 1), Member 11 2
     Type I1
Endothelial Plasminogen Activator Inhibitor2 3     Plasminogen Activator Inhibitor 12
Serpin E12 3     

External Ids:    HGNC: 85831   Entrez Gene: 50542   Ensembl: ENSG000001063667   OMIM: 1733605   UniProtKB: P051213   

Export aliases for SERPINE1 gene to outside databases

Previous GC identifers: GC07P099254 GC07P100316 GC07P100330 GC07P100363 GC07P100558 GC07P095363


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SERPINE1 Gene:
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal
inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis.
Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high
concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for SERPINE1 Gene: 
SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1) is a protein-coding gene. Diseases associated with SERPINE1 include central serous chorioretinopathy, and plasminogen activator inhibitor type 1 deficiency, and among its related super-pathways are Complement and Coagulation Cascades and Blood Coagulation Signaling Pathways. GO annotations related to this gene include protease binding and receptor binding. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121
Function: Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase,
protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the
regulation of fibrinolysis

Gene Wiki entry for SERPINE1 (Plasminogen activator inhibitor-1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINE1 gene promoter:
         AP-1   AML1a   JunB   AP-2gamma   GATA-2   CREB   HEN1   deltaCREB   SEF-1 (1)   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): SERPINE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

SERPINE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINE1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100770:  view genomic region     (about GC identifiers)

Start:
100,770,370 bp from pter      End:
100,782,547 bp from pter
Size:
12,178 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 100,128,766-100,140,934     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121 (See protein sequence)
Recommended Name: Plasminogen activator inhibitor 1 precursor  
Size: 402 amino acids; 45060 Da
Subunit: Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed
by internalization and degradation
Subcellular location: Secreted
6/17 PDB 3D structures from and Proteopedia for SERPINE1 (see all 17):
1A7C (3D)        1B3K (3D)        1C5G (3D)        1DB2 (3D)        1DVM (3D)        1DVN (3D)    
Secondary accessions: B7Z4S0 F8WD53
Alternative splicing: 2 isoforms:  P05121-1   P05121-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SERPINE1: NX_P05121

Explore proteomics data for SERPINE1 at MOPED 

Post-translational modifications:

  • UniProtKB: Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-
    -Met-370 bond
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05121

  • SERPINE1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERPINE1 Protein Expression
    REFSEQ proteins: NP_000593.1  
    ENSEMBL proteins: 
     ENSP00000223095   ENSP00000396766  
    Reactome Protein details: P05121
    Human Recombinant Protein Products for SERPINE1: 
    EMD Millipore Purified and/or Recombinant SERPINE1 Protein
    R&D Systems Recombinant & Natural Proteins for SERPINE1 (Serpin E1/PAI-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SERPINE1
    OriGene Protein Over-expression Lysate for SERPINE1
    OriGene MassSpec for SERPINE1 
    OriGene Custom Protein Services for SERPINE1
    GenScript Custom Purified and Recombinant Proteins Services for SERPINE1
    Novus Biologicals SERPINE1 Proteins
    Novus Biologicals SERPINE1 Lysates
    Sino Biological Recombinant Protein for SERPINE1
    Sino Biological Cell Lysate for SERPINE1 
    ProSpec Recombinant Protein for SERPINE1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA1695900
    GO:0005886plasma membrane TAS--
    GO:0031012extracellular matrix IDA1632457
    GO:0031093platelet alpha granule lumen TAS--

    SERPINE1 for ontologies           About GeneDecksing



    SERPINE1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SERPINE1
    R&D Systems Antibodies for SERPINE1 (Serpin E1/PAI-1)
    Cell Signaling Technology (CST) Antibodies for SERPINE1 
    OriGene Antibodies for SERPINE1
    OriGene Custom Antibody Services for SERPINE1
    GenScript Custom Superior Antibodies Services for SERPINE1
    Novus Biologicals SERPINE1 Antibodies
    Abcam antibodies for SERPINE1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for SERPINE1
    LSBio Antibodies in human, mouse, rat for SERPINE1 

    Assay Products for SERPINE1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SERPINE1
    R&D Systems ELISAs for SERPINE1 (Serpin E1/PAI-1)         (see all)
    GenScript Custom Assay Services for SERPINE1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P05121

    ProtoNet protein and cluster: P05121

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121
    Similarity: Belongs to the serpin family


    SERPINE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAI1_HUMAN, P05121
    Function: Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase,
    protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the
    regulation of fibrinolysis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI12114510
    GO:0004867serine-type endopeptidase inhibitor activity IDA1695900
    GO:0005102contributes to receptor binding IPI8626514
    GO:0005515protein binding IPI16272158
         
    SERPINE1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERPINE1:
     Decreased melanin production  Increased HPV18 LCR reporter a 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Serpine1):
     adipose tissue  cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  renal/urinary system 
     respiratory system  tumorigenesis 

    SERPINE1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Serpine1tm1Mlg for SERPINE1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SERPINE1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERPINE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINE1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERPINE1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SERPINE1:
    hsa-mir-99a (MIRT005973), hsa-mir-30c (MIRT005971), hsa-mir-204 (MIRT005844), hsa-mir-301a (MIRT005972)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINE1
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINE1 (see all 43):
    hsa-miR-3616-5p hsa-miR-624 hsa-miR-30d hsa-miR-342-3p hsa-miR-449a hsa-miR-30a hsa-miR-642b hsa-miR-3174
    SwitchGear 3'UTR luciferase reporter plasmidSERPINE1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SERPINE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINE1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SERPINE1
    Sirion Biotech Customized adenovirus for overexpression of SERPINE1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SERPINE1 (see all 14)
    OriGene ORF clones in mouse, rat for SERPINE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SERPINE1 (NM_000602)
    Sino Biological Human cDNA Clone for SERPINE1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINE1
    Sirion Biotech Customized lentivirus for stable overexpression of SERPINE1 
                         Customized lentivirus expression plasmids for stable overexpression of SERPINE1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SERPINE1
    LifeMap BioReagents: cell line associated with SERPINE1: PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SERPINE1 About   (see all 33)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    2Formation of Fibrin Clot (Clotting Cascade)
    Blood Coagulation Signaling Pathways0.51
    Blood Clotting Cascade0.42
    3Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer0.63
    Signaling by TGF-beta Receptor Complex0.61
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription0.63
    4Platelet degranulation
    Platelet degranulation 0.94
    Response to elevated platelet cytosolic Ca2+0.94
    5Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for SERPINE1
        Development Glucocorticoid receptor signaling
    Cell adhesion PLAU signaling
    Cell adhesion ECM remodeling
    Development TGF-beta receptor signaling
    Immune response IL-1 signaling pathway

    1 R&D Systems Pathway for SERPINE1
        Blood Coagulation Signaling Pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SERPINE1
        UPA-UPAR Pathway

    2 Cell Signaling Technology (CST) Pathways for SERPINE1
        Adhesion
    TGF-beta/Smad Signaling

    5 GeneGo (Thomson Reuters) Pathways for SERPINE1
        Cell adhesion PLAU signaling
    Cell adhesion ECM remodeling
    Development TGF-beta receptor signaling
    Development Glucocorticoid receptor signaling
    Immune response IL-1 signaling pathway

    5/12 BioSystems Pathways for SERPINE1 (see all 12)
        Senescence and Autophagy
    TGF Beta Signaling Pathway
    Blood Clotting Cascade
    Adipogenesis
    Oncostatin M Signaling Pathway


    5/15        Reactome Pathways for SERPINE1 (see all 15)
        Hemostasis
    Circadian Clock
    Generic Transcription Pathway
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Response to elevated platelet cytosolic Ca2+


    5         Kegg Pathways  (Kegg details for SERPINE1):
        HIF-1 signaling pathway
    p53 signaling pathway
    Hippo signaling pathway
    Complement and coagulation cascades
    Chagas disease (American trypanosomiasis)


    SERPINE1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/75 Interacting proteins for SERPINE1 (P051211, 2, 3 ENSP000002230954) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ORM1P027631, 3, ENSP000002593964EBI-953978,EBI-976767 I2D: score=3 STRING: ENSP00000259396
    PLATP007502, 3, ENSP000002208094MINT-8309311 I2D: score=3 STRING: ENSP00000220809
    PLAUP007492, 3, ENSP000003618504MINT-8309294 I2D: score=3 STRING: ENSP00000361850
    VTNP040042, 3, ENSP000002262184MINT-24884 I2D: score=4 STRING: ENSP00000226218
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2861504 I2D: score=3 STRING: ENSP00000357292
    About this table

    Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001300chronological cell aging IEP18974388
    GO:0001525angiogenesis IEP11866539
    GO:0002576platelet degranulation TAS--
    GO:0006351transcription, DNA-dependent TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    SERPINE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINE1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for SERPINE1

    Browse Tocris compounds for SERPINE1 (PAI1)

    3 HMDB Compounds for SERPINE1    About this table
    CompoundSynonyms CAS #PubMed Ids
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
    Dimethyl sulfoxide(methylsulfinyl)methane;Dimethyl sulfoxide (see all 5)67-68-5--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    7 DrugBank Compounds for SERPINE1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Troglitazone-- 97322-87-7targetantagonist10770198 10418858 10831180 10768100 10871202
    UrokinaseU-plasminogen activator (see all 3)9039-53-6target--12785198 12579271 12745435 12709915 12642587
    Drotrecogin alfaAnticoagulant protein C (see all 4)60202-16-6target--12004248 11259926 14515185 17566522
    Tenecteplaset- PA (see all 4)191588-94-0target--17963464 11163592 14564902
    Alteplaset-PA (see all 4)105857-23-6target--17963464
    Anistreplaset- PA (see all 4)81669-57-0target--17963464
    Reteplaset- PA (see all 4)133652-38-7target--17963464

    10/130 Novoseek inferred chemical compound relationships for SERPINE1 gene (see all 130)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 90.2 1414 11770837 (7), 9361687 (6), 9843166 (6), 18948960 (6) (see all 99)
    cholesterol 68.8 409 8475477 (4), 12167171 (3), 20205861 (3), 15260879 (2) (see all 99)
    homocysteine 65.7 248 15994914 (6), 10872824 (5), 16363254 (5), 10365747 (5) (see all 94)
    glucose 64.2 559 17275007 (6), 7519664 (6), 15863881 (6), 16235542 (5) (see all 99)
    serine 63.8 210 12848892 (4), 1901356 (2), 1601844 (2), 7498551 (2) (see all 99)
    metformin 57.3 72 9109854 (5), 11158071 (4), 11953071 (3), 12669266 (3) (see all 34)
    n-867 54.7 1 10634818 (1)
    aprotinin 53.3 32 8857924 (2), 19521296 (2), 9130470 (2), 15668193 (2) (see all 21)
    tgf beta1 51 53 17095240 (6), 11505481 (6), 15268802 (4), 16686283 (3) (see all 20)
    tranexamic acid 51 10 18362590 (3), 8478593 (1), 19521296 (1), 8015955 (1) (see all 7)

    3 PharmGKB related drug/compound annotations for SERPINE1 gene    About this table
    Drug/compound PharmGKB Annotation
    antidepressantsCA  
    citalopramCA  
    fluoxetineCA  

    Search CenterWatch for drugs/clinical trials and news about SERPINE1 / PAI1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERPINE1 gene (2 alternative transcripts): 
    NM_000602.4  NM_001165413.2  

    Unigene Clusters for SERPINE1:

    Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    Hs.414795  [show with all ESTs], Hs.741440  [show with all ESTs]
    Unigene Representative Sequences: NM_000602, BX360178
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223095(uc011kkj.2 uc003uxt.3) ENST00000445463(uc003uxu.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINE1
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINE1 (see all 43):
    hsa-miR-3616-5p hsa-miR-624 hsa-miR-30d hsa-miR-342-3p hsa-miR-449a hsa-miR-30a hsa-miR-642b hsa-miR-3174
    SwitchGear 3'UTR luciferase reporter plasmidSERPINE1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SERPINE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINE1
    Clone
    Products:
         
    OriGene clones in human, mouse for SERPINE1 (see all 14)
    OriGene ORF clones in mouse, rat for SERPINE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SERPINE1 (NM_000602)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINE1
    Sirion Biotech Customized lentivirus for stable overexpression of SERPINE1 
                         Customized lentivirus expression plasmids for stable overexpression of SERPINE1 
    Primer
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    OriGene qPCR primer pairs and template standards for SERPINE1
    OriGene qSTAR qPCR primer pairs in human, mouse for SERPINE1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERPINE1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINE1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINE1

    Additional mRNA sequence: X04729.1 

    24/33 DOTS entries (see all 33):

    DT.92398371  DT.95341219  DT.100889494  DT.455508  DT.100889484  DT.100889482  DT.100889505  DT.100044845 
    DT.121059724  DT.91779718  DT.97809442  DT.100889466  DT.75124115  DT.100889507  DT.92050306  DT.95252001 
    DT.120290  DT.121059737  DT.91926506  DT.100889475  DT.100889500  DT.121059641  DT.95252013  DT.97768277 

    21 AceView cDNA sequences:

    BC010860 CR605271 CR605789 BC005927 CR625802 NM_000602 CR604690 CR603052 
    CR622616 M16006 CR614829 BC020765 X04429 M14083 X12701 X04744 
    BF107037 X04731 X04729 BG565637 BX649164 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINE1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
    SP1:                                                                                                
    SP2:                                -     -                                                         
    SP3:        -                                                                                       
    SP4:        -     -     -     -     -                                                               
    SP5:                    -     -     -     -     -     -                                             


    ECgene alternative splicing isoforms for SERPINE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINE1 expression in normal human tissues (normalized intensities)      SERPINE1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAAATGTT
    SERPINE1 Expression
    About this image


    SERPINE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Fibroblast
             Detroit 551
             Human Prostate Fibroblasts (HPrF)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 5 entries
             Wharton's jelly-derived stem cells
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mural Cells Splanchnic Mesoderm
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Peripheral blood-derived endothelial progenitor cells
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Basal Cells Respiratory Bronchioles
             Human Pulmonary Artery Smooth Muscle Cells (HPASMC)   

    See SERPINE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINE1

    SOURCE GeneReport for Unigene clusters: Hs.414795 Hs.741440

    UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121
    Tissue specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including SERPINE1 (see all 23): 
              Insulin Signaling Pathway in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Wound Healing in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINE1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SERPINE1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpine11 , 5 serine (or cysteine) peptidase inhibitor, clade E, more1, 5 80.76(n)1
    79.1(a)1
      5 (76.16 cM)5
    187871  NM_008871.21  NP_032897.21 
     1370615045 
    lizard
    (Anolis carolinensis)
    Reptilia SERPINE16
    Uncharacterized protein
    66(a)
    1 ↔ 1
    AAWZ02040481(991-6819)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.250942 Xenopus laevis transcribed sequence with weak similarity more 76.56(n)    BJ079964.1 
    zebrafish
    (Danio rerio)
    Actinopterygii serpine11 serpin peptidase inhibitor, clade E (nexin, plasminogen more 56.55(n)
    45.4(a)
      100136840  NM_001114559.1  NP_001108031.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spn66
    Spn16
    (see all 17)
    Serine protease inhibitor 1
    (see all 17)
    29(a)
    28(a)
    (see all 17)
    many ↔ many
    many ↔ many
    (see all 17)
    2R(14013810-14015715)
    2R(2770786-2772378)
    worm
    (Caenorhabditis elegans)
    Secernentea srp-66
    srp-76
    (see all 6)
    Protein SRP-7, isoform d
    (see all 6)
    25(a)
    25(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    V(7384232-7386306)
    V(8179131-8183442)


    ENSEMBL Gene Tree for SERPINE1 (if available)
    TreeFam Gene Tree for SERPINE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINE1 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB32  SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINB112  SERPINE32  
    SERPINB132  SERPINB82  
    18/26 SIMAP similar genes for SERPINE1 using alignment to 1 protein entry:     PAI1_HUMAN(see all similar genes):
    SERPINI1    SERPINE2    SERPINC1    SERPINI2    SERPINA1    SERPINA9
    SERPINB4    SERPINA5    SERPINA6    SERPINB3    SERPINB8    SERPINB9
    SERPINA10    SERPINA3    SERPINA4    SERPINB6    SERPINB7    SERPINB11

    SERPINE1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/537 SNPs in SERPINE1 are shown (see all 537)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60921,2,4
    C,F,Hpathogenic1104137316(+) GCCTGG/ACCCTT 2 /T /A mis1 ese322Minor allele frequency- A:0.09MN NA EA NS EU 9533
    rs361723841,2
    C--95369770(+) TCTCA-/AAAC  
            
    AAACA
    1 -- int11Minor allele frequency- AAAC:0.00CSA 2
    rs2017446521,2
    C--100134393(+) CATTC-/AAAAA 
     AAAAAAA
    AAAAA
    1 -- int10--------
    rs602951751,2
    C--100134414(+) AAAAA-/A/AAAA
    AAAAAAAA
    GGATG
    2 -- int1 cds11NA 2
    rs676516511,2
    C--100138124(+) GAAAG-/AC/C  
      A
    /GAAA
    AAAGA
    1 -- int10--------
    rs58861631,2
    C--100138125(+) AAAGA-/AC/CA 
            
    AAGAA
    1 -- int1 trp30--------
    rs362282731,2
    C--100768755(+) AAAAA-/ACAAAA 1 -- us2k10--------
    rs17997621,2
    C,F--100769706(+) TGGGG-/GAGTCA 1 -- us2k14Minor allele frequency- G:0.47NS NA 282
    rs22276491,2
    C,F--100772243(+) GCTCAAA/-CGCCT 1 -- int12Minor allele frequency- -:0.04NS 92
    rs595022271,2
    C--100772942(+) AGAAA-/AGAA/GAAA/
    GAAACAAAGAAA
    CAAAG
    2 -- int1 cds11NA 2

    HapMap Linkage Disequilibrium report for SERPINE1 (100770370 - 100782547 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SERPINE1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    esv2422376CNV Duplication17116639
    nsv831075CNV Loss17160897


    Human Gene Mutation Database (HGMD): SERPINE1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SERPINE1
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 173360   
    OMIM disorders: 613329  
    UniProtKB/Swiss-Prot: PAI1_HUMAN, P05121
  • Plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:613329]: A hematologic disorder characterized
    by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is
    due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which
    inhibits tissue and urinary activators of plasminogen. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial
    occlusions

  • 20/262 diseases for SERPINE1 (see all 262):    About MalaCards
    central serous chorioretinopathy    plasminogen activator inhibitor type 1 deficiency    prediabetes syndrome    inferior vena cava interruption
    lymphangitis    carotid artery thrombosis    metabolic syndrome x    amaurosis fugax
    familial encephalopathy with neuroserpin inclusion bodies    hepatic vein thrombosis    neonatal stroke    paranasal sinus disease
    central retinal artery occlusion    thromboangiitis obliterans    coronary thrombosis    thrombophilia
    legg-calve-perthes disease    angiodysplasia    vascular disease    thromboembolism

    12 diseases from the University of Copenhagen DISEASES database for SERPINE1:
    Heart disease     Diabetes mellitus     Atherosclerosis     Hypertension
    Thrombophilia     Cerebrovascular accident     Kidney disease     Hyperinsulinism
    Hyperglycemia     Lung disease     Hemorrhagic disease     Polycystic ovary syndrome

    SERPINE1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/95 Novoseek inferred disease relationships for SERPINE1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 78.2 427 1916049 (5), 11849662 (5), 11719834 (5), 8862693 (4) (see all 99)
    thrombophilia 78 35 14653439 (4), 11525850 (1), 8003387 (1), 8522567 (1) (see all 27)
    thrombosis 76.6 210 8379599 (4), 9631870 (3), 17896948 (3), 15820196 (3) (see all 99)
    cardiovascular diseases 75.2 192 18050673 (3), 9187410 (2), 10695479 (2), 16039281 (2) (see all 99)
    atherosclerosis 72.2 179 14593385 (4), 9187938 (4), 9159836 (3), 10064006 (2) (see all 99)
    venous occlusion 69.3 77 1631786 (6), 12067144 (3), 1783249 (2), 8259554 (2) (see all 43)
    insulin sensitivity 68.3 96 8049187 (6), 9484991 (5), 8104834 (4), 9102176 (3) (see all 54)
    obesity 66.4 305 11816701 (5), 10764686 (5), 16293162 (4), 18175742 (4) (see all 99)
    niddm 64.1 175 8633110 (7), 8822587 (5), 9187410 (4), 9126661 (4) (see all 66)
    hyperinsulinemia 64.1 75 10867719 (2), 8633110 (2), 8036449 (2), 8387542 (2) (see all 46)

    Genetic Association Database (GAD): SERPINE1
    Human Genome Epidemiology (HuGE) Navigator: SERPINE1 (508 documents)

    Export disorders for SERPINE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINE1 gene, integrated from 9 sources (see all 3906):
    (articles sorted by number of sources associating them with SERPINE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of human plasminogen activator-inhibitor from endothelial cells. (PubMed id 3097076)1, 2, 3 Ginsburg D.... Gelehrter T.D. (1986)
    2. The plasminogen activator inhibitor-1 (PAI-1) promoter haplotype is related to PAI-1 plasma concentrations in lean individuals. (PubMed id 16039281)1, 4, 9 Verschuur M....de Maat M.P. (2005)
    3. Plasminogen activator inhibitor activity, 4G5G polymorphism of the plasminogen activator inhibitor 1 gene, and first-trimester miscarriage in women with polycystic ovary syndrome. (PubMed id 16483878)1, 4, 9 Glueck C.J....Wang P. (2006)
    4. Plasma PAI-1 levels in obese children--effect of weight loss and influence of PAI-1 promoter 4G/5G genotype. (PubMed id 11522017)1, 4, 9 Estelles A....Aznar J. (2001)
    5. Investigation of SERPINE1 genetic polymorphism in Mac edonian patients with occlusive artery disease and deep vein thrombosis. (PubMed id 20017074)1, 4, 9 Spiroski I....Spiroski M. (2009)
    6. Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene. (PubMed id 9207454)1, 2, 9 Fay W.P....Shapiro A.D. (1997)
    7. The -675 4G/5G polymorphism at the Plasminogen Activator Inhibitor 1 (PAI-1) gene modulates plasma Plasminogen Activator Inhibitor 1 concentrations in response to dietary fat consumption. (PubMed id 17903340)1, 4, 9 Perez-Martinez P....Perez-Jimenez F. (2008)
    8. Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. (PubMed id 17119035)1, 4, 9 Sternlicht M.D....Werb Z. (2006)
    9. Plasminogen activator inhibitor-1 and outcome after femoropopliteal angioplasty: analysis of genotype and plasma levels. (PubMed id 14515194)1, 4, 9 Mlekusch W....Wagner O. (2003)
    10. Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population. (PubMed id 18953568)1, 4, 9 Schoenhard J.A....Williams S.M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5054 HGNC: 8583 AceView: SERPINE1 Ensembl:ENSG00000106366 euGenes: HUgn5054
    ECgene: SERPINE1 Kegg: 5054 H-InvDB: SERPINE1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINE1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERPINE1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SERPINE1
    Wikipedia http://en.wikipedia.org/wiki/Plasminogen_activator_inhibitor-1
    SeattleSNPshttp://pga.gs.washington.edu/data/serpine1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERPINE1 gene:
    Search GeneIP for patents involving SERPINE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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