Aliases for SERPIND1 Gene
External Ids for SERPIND1 Gene
Previous HGNC Symbols for SERPIND1 Gene
Previous GeneCards Identifiers for SERPIND1 Gene
This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]
GeneCards Summary for SERPIND1 Gene
SERPIND1 (Serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1) is a Protein Coding gene. Diseases associated with SERPIND1 include thrombophilia due to heparin cofactor ii deficiency and hydrolethalus syndrome 2. Among its related pathways are Hemostasis and Complement and coagulation cascades. GO annotations related to this gene include heparin binding and endopeptidase inhibitor activity. An important paralog of this gene is SERPINA10.
UniProtKB/Swiss-Prot for SERPIND1 Gene
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.