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SERPINC1 Gene

protein-coding GIFtS: 63

GC01M172139

serpin peptidase inhibitor, clade C (antithrombin), member 1
(Previous names: serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: AT3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AT3 ^², ³
ATIII ^¹, ², ³
MGC22579 ^¹, ²
OTTHUMP00000035393 ^²

Descriptions
antithrombin (aa 375-432) ^²
antithrombin III ^²
coding sequence signal peptide antithrombin part 1 ^²
serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 ^¹, ²
serpin peptidase inhibitor, clade C (antithrombin), member 1 ^²
serpin peptidase inhibitor, clade C, member 1 ^²
signal peptide antithrombin part 1 ^²

External Ids
HGNC: 775¹
Entrez Gene: 462²
UniProtKB: P01008³
Ensembl: ENSG00000117601⁷

Search outside databases for aliases for SERPINC1 gene

Previous GC identifers: GC01M171412 GC01M169301 GC01M170453 GC01M171112 GC01M170604

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ANT3_HUMAN, P01008

Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation

cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is

greatly enhanced in the presence of heparin

Gene Wiki entry for SERPINC1 (Antithrombin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SERPINC1 gene

Entrez Gene cytogenetic band: 1q23-q25.1 Ensembl cytogenetic band: 1q25.1 HGNC cytogenetic band: 1q23-q25.1

SERPINC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M172139: (about GC identifiers)

Start:	172,139,562 bp from pter
End:	172,153,096 bp from pter
Size:	13,535 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ANT3_HUMAN, P01008 (See protein sequence)

Recommended Name: Antithrombin-III precursor

Size: 464 amino acids; 52602 Da

Subcellular location: Secreted, extracellular space

Mass spectrometry: Mass=57863; Method=Electrospray; Range=33-464; Source=PubMed:7734359;

Mass spectrometry: Mass=57911; Method=Electrospray; Range=33-464; Note=Variant Thr-414;

Source=PubMed:7734359;

PDB structures from and Proteopedia :

1ANT (3D)

1ATH (3D)

1AZX (3D)

1BR8 (3D)

1DZG (3D)

1DZH (3D)

1E03 (3D)

1E04 (3D)

1E05 (3D)

1JVQ (3D)

1LK6 (3D)

1NQ9 (3D)

1OYH (3D)

1R1L (3D)

1SR5 (3D)

1T1F (3D)

1TB6 (3D)

2ANT (3D)

2B4X (3D)

2B5T (3D)

2BEH (3D)

2GD4 (3D)

2HIJ (3D)

2ZNH (3D)

3EVJ (3D)

Secondary accessions: B2R6P0 P78439 P78447 Q13815 Q5TC78 Q7KZ43 Q7KZ97 Q9UC78

REFSEQ proteins: NP_000479.1

ENSEMBL proteins:

ENSP00000356671 ENSP00000307953

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for SERPINC1
	R&D Systems Recombinant & Natural Proteins for SERPINC1 (Serpin C1/Antithrombin-III)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Antithrombin III)
	Human Recombinant Proteins from Abnova (SERPINC1)

OriGene Purified Recombinant Human Protein: SERPINC1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005886	plasma membrane	EXP	12907439

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Antibodies for SERPINC1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of SERPINC1
	Sigma-Aldrich Antibodies for SERPINC1
	R&D Systems Antibodies for SERPINC1 (Serpin C1/Antithrombin-III)
	Antibodies from Abcam (Antithrombin III), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for SERPINC1

Assays for SERPINC1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01008

ProtoNet protein and cluster: P01008

1 Blocks protein family: IPB000215 Serpin

UniProtKB/Swiss-Prot: ANT3_HUMAN, P01008

Similarity: Belongs to the serpin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SERPINC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SERPINC1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000488

Applied Biosystems Silencer® siRNAs for SERPINC1

Sigma-Aldrich siRNA and siRNA Panels for SERPINC1

Sigma-Aldrich shRNA Panels and shRNA for SERPINC1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SERPINC1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000488
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000488
untagged cDNA clone in CMV expression vector: NM_000488

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000488

UniProtKB/Swiss-Prot: ANT3_HUMAN, P01008

Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation

cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is

greatly enhanced in the presence of heparin

15 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Serpinc1):

	embryogenesis	hematopoietic system	homeostasis/metabolism	immune system
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	muscle
nervous system	pigmentation	renal/urinary system	reproductive system	vision/eye

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IPI	15853774
GO:0004867	serine-type endopeptidase inhibitor activity	NAS	12878203
GO:0005515	protein binding	IPI	12878203
GO:0008201	heparin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for SERPINC1 (Your Favorite Gene powered by Ingenuity)

Coagulation System

GeneDecks SERPINC1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for SERPINC1

5/62 Interacting proteins for SERPINC1 (P01008¹ ENSP00000356671³) via UniProtKB, MINT, and/or STRING (see all 62 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLCG1	P19174¹	EBI-1039832, EBI-79387
F10	ENSP00000364709³	STRING (score=.999)
PLG	ENSP00000308938³	STRING (score=.996)
F9	ENSP00000218099³	STRING (score=.993)
PROC	ENSP00000234071³	STRING (score=.993)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007596	blood coagulation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SERPINC1
10/17 Novoseek chemical compound relationships for SERPINC1 gene (see all 17 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	93.44	1250	9746270 (5), 8545565 (5), 18728028 (5), 16444428 (4) (see all 99)
heparin pentasaccharide	90.27	42	9242619 (3), 12353073 (2), 9541411 (2), 10433728 (1) (see all 30)
hirugen	71.48	8	8706141 (2), 7781782 (1), 14512086 (1), 10457984 (1) (see all 6)
heparan sulfate	67.22	83	11006120 (3), 7542805 (2), 12138164 (2), 9213829 (2) (see all 56)
homocysteine	65.69	112	12080632 (3), 8176841 (3), 17669712 (2), 15934123 (2) (see all 88)
p-amino benzamidine	64.65	1	10648407 (1)
4-vinylaniline	61.98	1	1457941 (1)
fibrinopeptide a	61.26	7	7516205 (1), 9769933 (1), 7952409 (1), 7603735 (1) (see all 5)
glycosaminoglycan	59.01	32	7888673 (2), 1740413 (2), 7806495 (2), 8429040 (1) (see all 22)
rivaroxaban	57.96	3	17404541 (1), 19170587 (1), 17701479 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SERPINC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SERPINC1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000488

Sigma-Aldrich siRNA and siRNA Panels for SERPINC1

Sigma-Aldrich shRNA Panels and shRNA for SERPINC1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000488

REFSEQ mRNAs for SERPINC1 gene:

NM_000488.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000488

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000488
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000488
                                 untagged cDNA clone in CMV expression vector: NM_000488

Additional cDNA sequence:

AF130100.1 AK312654.1 BC022309.1 CR619869.1 D29832.1

9 DOTS entries:

DT.417074 DT.95152449 DT.91754456 DT.100815145 DT.91754464 DT.95226132 DT.100815146 DT.91754455

DT.121424933

24/60 AceView cDNA sequences (see all 60 ):

AV646887 AV656549 AV654825 AV661445 AL532135 AV691715 AV648982 AV647437

AV686233 AV648634 BC022309 BG567450 AV653713 BG564842 AV655960 AV695001

AV657158 BG567126 AV682951 AV684449 AV661758 AV647404 BG617043 AV647313

highest scoring ESTs for SERPINC1:

AL532135 AV686225 AV690770 AV691885 BE971193 BG562782 BG563372 BG564415 BG564766 BG567126

Unigene Cluster for SERPINC1:

Serpin peptidase inhibitor, clade C (antithrombin), member 1

Hs.75599 [show with all ESTs]

Unigene Representative Sequence: AF130100

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINC1

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9
SP1:							-		-		-
SP2:							-		-		-										-		-		-		-
SP3:							-
SP4:							-		-
SP5:											-

About this scheme

ECgene alternative splicing isoforms for SERPINC1

2 Ensembl transcripts including schematic representations:

ENST00000367698 ENST00000351522

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SERPINC1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SERPINC1

¹ / ² / ³

4 probe-sets matching SERPINC1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37175_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L00190	0.20	1.00	0.72	1
210049_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D29832	0.80	1.00	0.91	1
1554491_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210049_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SERPINC1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCAGAGTAG

SOURCE GeneReport for Unigene cluster: Hs.75599
Expression variation in blood from EXPOLDB for SERPINC1
UniProtKB/Swiss-Prot: ANT3_HUMAN, P01008
Tissue specificity: Found in plasma

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SERPINC1 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SERPINC1¹	--	serpin peptidase inhibitor, clade C (antithrombin), more	86.44(n) 87.01(a)	480066 XM_845386.1 XP_850479.1
chimpanzee (Pan troglodytes)	SERPINC1¹	--	serpin peptidase inhibitor, clade C (antithrombin), more	99.43(n) 99.57(a)	457528 XM_001151521.1 XP_001151521.1
cow (Bos taurus)	SERPINC1¹	--	serpin peptidase inhibitor, clade C (antithrombin), more	87.69(n) 87.26(a)	540261 NM_001034698.1 NP_001029870.1
rat (Rattus norvegicus)	Serpinc1¹	--	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), more	84.74(n) 85.96(a)	304917 NM_001012027.1 NP_001012027.1
mouse (Mus musculus)	Serpinc1^{1, 5}	1 (84.60 cM)⁵	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), more^{1, 5}	85.6(n)¹ 87.69(a)¹	11905¹ NM_080844.3¹ NP_543120.1¹ AB043785⁵ AI114908⁵ (see all 11)

About this table Species with no ortholog for SERPINC1

ENSEMBL Gene Tree for SERPINC1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SERPINC1 gene

SERPINH1² SERPINB5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/104 NCBI SNPs in SERPINC1 are shown (see all 104 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 58)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2227624^1,2	C,F,H	172150633(-)	`CTGCGT/AGACCT`	1	E/V	mis¹ ese³		9	NS EA WA EU	800
	rs2227588^1,2	C,F,H	172154066(-)	`CATGGA/GGGGCT`	1	--	ng3¹		7	NS EU EA WA	1620
--	rs2227606^1,2	C,F,H	172147745(-)	`AGAAAA/GCATCT`	1	T/A	mis¹ ese³		19	NS EU EA WA NA	1734
	rs11582923^1,2	C,H	172154964(+)	`GAACAT/ACGCTG`	1	--	ng3¹		4	EU EA WA	416
	rs2227587^1,2	F,H	172154247(-)	`CCCCCG/AAATGG`	1	--	ng3¹		6	NS EU EA WA	498
	rs2227619^1,2	H	172139067(-)	`CTCTTT/GCTTTG`	1	--	ng5¹		6	NS EU EA WA	484
--	rs2227586^1,2	F	172154297(-)	`CACCAC/TGCTTG`	1	--	ng3¹		2	NS	94
	rs5877^1,2	A,C,F,H	172145485(-)	`AAGGTG/AGAGAA`	1	V/V	syn¹ trp³		14	MN NS EU EA WA	1448
	rs5878^1,2	A,C,F,H	172145455(-)	`CTGCAG/AGAGTG`	1	Q/Q	syn¹		12	MN NS NA EA EU WA	1159
	rs5879^1,2	F	172139695(-)	`CTGAAC/TACTAT`	1	N/N	syn¹ ese³		2	MN	200

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HapMap Linkage Disequilibrium images for SERPINC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 107300

UniProtKB/Swiss-Prot: ANT3_HUMAN, P01008

Defects in SERPINC1 are the cause of antithrombin-III deficiency (AT3D) [MIM:107300]. AT3D

is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a

tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50%

decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding

domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are

normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations

10/99 Novoseek disease relationships for SERPINC1 gene (see all 99 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
antithrombin iii deficiency	96.25	262	12897104 (4), 18926244 (3), 10987006 (3), 9479609 (3) (see all 99)
thrombophilia	93.85	205	10625206 (3), 9630308 (2), 17107615 (2), 18760065 (2) (see all 99)
protein s deficiency	91.98	147	15706484 (3), 9746774 (3), 9003158 (2), 11486107 (2) (see all 99)
apc resistance	91.64	166	16422365 (2), 8834124 (2), 9865798 (2), 10195932 (2) (see all 99)
thrombosis	89.29	332	12888870 (5), 8148939 (4), 18575842 (4), 9764672 (3) (see all 99)
protein c deficiency	88.92	80	2363123 (2), 17244921 (2), 12542252 (2), 9158617 (2) (see all 75)
disseminated intravascular coagulation	88.01	111	8572009 (3), 8813091 (3), 9662467 (2), 9577159 (2) (see all 82)
thromboembolism	86.89	123	19132194 (4), 10515862 (3), 11127851 (2), 9342999 (2) (see all 91)
venous thrombosis	86.32	144	1696577 (4), 12542252 (3), 9479609 (3), 12492585 (2) (see all 99)
coagulopathy	81.89	50	7514043 (3), 1638825 (1), 8419725 (1), 9008760 (1) (see all 42)

About this table

Human Gene Mutation Database: SERPINC1
Genetic Association Database: SERPINC1
Human Genome Epidemiology Navigator: SERPINC1 (8 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/2302 PubMed articles for SERPINC1 gene (see all 2302 ):

Antithrombin Phe229Leu: a new homozygous variant leading to spontaneous antithrombin polymerization in vivo associated with severe childhood thrombosis. (PubMed id 12595305)^{1, 3, 4, 6} Picard V.... Aiach M. (2003)
Antithrombin III Nagasaki (Ser116-Pro): a heterozygous variant with defective heparin binding associated with thrombosis. (PubMed id 8443391)^{1, 3, 4, 6} Okajima K.... Takatsuki K. (1993)
Three novel missense mutations in the antithrombin III (AT3) gene causing recurrent venous thrombosis. (PubMed id 7959685)^{1, 3, 4} Millar D.S.... Cooper D.N. (1994)
Site-directed mutagenesis of alanine-382 of human antithrombin III. (PubMed id 2013320)^{1, 3, 4} Austin R.C.... Blachjman M.A. (1991)
Retinal vein occlusion associated with antithrombin deficiency secondary to a novel G9840C missense mutation. (PubMed id 16908819)^{1, 3, 4} Kuhli C.... Hattenbach L.-O. (2006)
Antithrombin 'DREUX' (Lys 114Glu): a variant with complete loss of heparin affinity. (PubMed id 12353073)^{1, 3, 4} Mushunje A.... Carrell R.W. (2002)
Antithrombin III Kumamoto II; a single mutation at Arg393-His increased the affinity of antithrombin III for heparin. (PubMed id 7832187)^{1, 3, 4} Okajima K.... Takatsuki K. (1995)
Antithrombin Cambridge II, 384 Ala to Ser. Further evidence of the role of the reactive centre loop in the inhibitory function of the serpins. (PubMed id 1906811)^{1, 3, 4} Perry D.J....Carrell R.W. (1991)
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{3, 4} Lewandrowski U.... Sickmann A. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 462	HGNC: 775	AceView: SERPINC1	Ensembl:ENSG00000117601	euGenes: HUgn462
ECgene: SERPINC1	H-InvDB: SERPINC1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Antithrombin
Antithrombin mutation database	http://www1.imperial.ac.uk/medicine/about/divisions/is/haemo/coag/antithrombin/
GeneReviews	http://www.genetests.org/query?gene=SERPINC1
SeattleSNPs	http://pga.gs.washington.edu/data/serpinc1/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=SERPINC1

Licensable Technologies for SERPINC1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SERPINC1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SERPINC1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SERPINC1		Antibodies for SERPINC1
	Explore super-pooled esiRNAs		Proteins for SERPINC1
	Lentivirus-delivered shRNAs for SERPINC1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SERPINC1)
	Search for Antibodies
	Chimera RNAi (SERPINC1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Antithrombin III)
	Antibodies (Antithrombin III)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for SERPINC1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SERPINC1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
SERPINC1 Gene at Home site.
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SERPINC1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for SERPINC1

Summaries
for SERPINC1

Genomic Location
for SERPINC1

Proteins
for SERPINC1

Protein Domains/
Families
for SERPINC1

Gene Function
for SERPINC1

Pathways & Interactions
for SERPINC1

Drugs & Compounds
for SERPINC1

Transcripts
for SERPINC1

Expression
for SERPINC1

Orthologs
for SERPINC1

Paralogs
for SERPINC1

SNPs/Variants
for SERPINC1

Disorders & Mutations
for SERPINC1

Medical News
for SERPINC1

Publications
for SERPINC1

Search for SERPINC1

Genome Databases showing SERPINC1

Other Databases showing SERPINC1

Specialized Databases showing SERPINC1

Licensable Technologies
for SERPINC1

Services
for SERPINC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SERPINC1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor SERPINC1

Summariesfor SERPINC1

Genomic Locationfor SERPINC1

Proteinsfor SERPINC1

Protein Domains/Familiesfor SERPINC1

Gene Functionfor SERPINC1

Pathways & Interactionsfor SERPINC1

Drugs & Compoundsfor SERPINC1

Transcriptsfor SERPINC1

Expression for SERPINC1

Orthologsfor SERPINC1

Paralogsfor SERPINC1

SNPs/Variantsfor SERPINC1

Disorders & Mutationsfor SERPINC1

Medical Newsfor SERPINC1

Publicationsfor SERPINC1

Search for SERPINC1

Genome Databases showing SERPINC1

Other Databases showing SERPINC1

Specialized Databases showing SERPINC1

Licensable Technologiesfor SERPINC1

Servicesfor SERPINC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SERPINC1

Summaries
for SERPINC1

Genomic Location
for SERPINC1

Proteins
for SERPINC1

Protein Domains/
Families
for SERPINC1

Gene Function
for SERPINC1

Pathways & Interactions
for SERPINC1

Drugs & Compounds
for SERPINC1

Transcripts
for SERPINC1

Expression
for SERPINC1

Orthologs
for SERPINC1

Paralogs
for SERPINC1

SNPs/Variants
for SERPINC1

Disorders & Mutations
for SERPINC1

Medical News
for SERPINC1

Publications
for SERPINC1

Licensable Technologies
for SERPINC1

Services
for SERPINC1