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Aliases for SERPINB9 Gene

Aliases for SERPINB9 Gene

  • Serpin Family B Member 9 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 9 2 3
  • Cytoplasmic Antiproteinase 3 3 4
  • Peptidase Inhibitor 9 3 4
  • CAP-3 3 4
  • CAP3 3 4
  • PI-9 3 4
  • PI9 3 4
  • Serpin Peptidase Inhibitor, Clade B, Member 9 3
  • Protease Inhibitor 9 (Ovalbumin Type) 3
  • Testicular Tissue Protein Li 180 3

External Ids for SERPINB9 Gene

Previous HGNC Symbols for SERPINB9 Gene

  • PI9

Previous GeneCards Identifiers for SERPINB9 Gene

  • GC06M002872
  • GC06M002832
  • GC06M002760

Summaries for SERPINB9 Gene

Entrez Gene Summary for SERPINB9 Gene

  • This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

GeneCards Summary for SERPINB9 Gene

SERPINB9 (Serpin Family B Member 9) is a Protein Coding gene. Among its related pathways are Amoebiasis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB9 Gene

  • Granzyme B inhibitor.

Gene Wiki entry for SERPINB9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB9 Gene

Genomics for SERPINB9 Gene

Regulatory Elements for SERPINB9 Gene

Enhancers for SERPINB9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SERPINB9 on UCSC Golden Path with GeneCards custom track

Promoters for SERPINB9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SERPINB9 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERPINB9 Gene

Chromosome:
6
Start:
2,887,265 bp from pter
End:
2,903,312 bp from pter
Size:
16,048 bases
Orientation:
Minus strand

Genomic View for SERPINB9 Gene

Genes around SERPINB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB9 Gene

Proteins for SERPINB9 Gene

  • Protein details for SERPINB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50453-SPB9_HUMAN
    Recommended name:
    Serpin B9
    Protein Accession:
    P50453
    Secondary Accessions:
    • B2RBW3
    • Q5TD03

    Protein attributes for SERPINB9 Gene

    Size:
    376 amino acids
    Molecular mass:
    42404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERPINB9 Gene

Proteomics data for SERPINB9 Gene at MOPED

Post-translational modifications for SERPINB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINB9 Gene

Domains & Families for SERPINB9 Gene

Gene Families for SERPINB9 Gene

Protein Domains for SERPINB9 Gene

Suggested Antigen Peptide Sequences for SERPINB9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50453

UniProtKB/Swiss-Prot:

SPB9_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB9: view

Function for SERPINB9 Gene

Molecular function for SERPINB9 Gene

UniProtKB/Swiss-Prot Function:
Granzyme B inhibitor.

Gene Ontology (GO) - Molecular Function for SERPINB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP 17479112
genes like me logo Genes that share ontologies with SERPINB9: view
genes like me logo Genes that share phenotypes with SERPINB9: view

Animal Models for SERPINB9 Gene

MGI Knock Outs for SERPINB9:

Animal Model Products

CRISPR Products

miRNA for SERPINB9 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINB9 Gene

Localization for SERPINB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB9 Gene COMPARTMENTS Subcellular localization image for SERPINB9 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SERPINB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11463822
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SERPINB9: view

Pathways & Interactions for SERPINB9 Gene

SuperPathways for SERPINB9 Gene

Superpath Contained pathways
1 Amoebiasis
genes like me logo Genes that share pathways with SERPINB9: view

Pathways by source for SERPINB9 Gene

1 KEGG pathway for SERPINB9 Gene

Gene Ontology (GO) - Biological Process for SERPINB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IMP 22090449
GO:0010951 negative regulation of endopeptidase activity IMP 21795594
GO:0033668 negative regulation by symbiont of host apoptotic process IMP 22090449
GO:0042270 protection from natural killer cell mediated cytotoxicity IMP 21795594
GO:0043066 negative regulation of apoptotic process IMP 17237823
genes like me logo Genes that share ontologies with SERPINB9: view

No data available for SIGNOR curated interactions for SERPINB9 Gene

Drugs & Compounds for SERPINB9 Gene

(5) Drugs for SERPINB9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for SERPINB9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB9: view

Transcripts for SERPINB9 Gene

mRNA/cDNA for SERPINB9 Gene

Unigene Clusters for SERPINB9 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: -
SP2:

Relevant External Links for SERPINB9 Gene

GeneLoc Exon Structure for
SERPINB9
ECgene alternative splicing isoforms for
SERPINB9

Expression for SERPINB9 Gene

mRNA expression in normal human tissues for SERPINB9 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINB9 Gene

This gene is overexpressed in Nerve - Tibial (x4.9).

Protein differential expression in normal tissues from HIPED for SERPINB9 Gene

This gene is overexpressed in Tlymphocyte (8.5), Peripheral blood mononuclear cells (8.4), Testis (7.1), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERPINB9 Gene



SOURCE GeneReport for Unigene cluster for SERPINB9 Gene Hs.104879

genes like me logo Genes that share expression patterns with SERPINB9: view

Protein tissue co-expression partners for SERPINB9 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SERPINB9 Gene

Orthologs for SERPINB9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SERPINB9 35
  • 74.15 (n)
  • 67.91 (a)
SERPINB9 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINB9 35
  • 78.99 (n)
  • 74.47 (a)
SERPINB9 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinb9 35
  • 78.25 (n)
  • 68.98 (a)
Serpinb9 16
Gm11397 36
  • 62 (a)
OneToMany
Serpinb9 36
  • 69 (a)
OneToMany
Serpinb9b 36
  • 66 (a)
OneToMany
Serpinb9c 36
  • 61 (a)
OneToMany
Serpinb9d 36
  • 64 (a)
OneToMany
Serpinb9e 36
  • 63 (a)
OneToMany
Serpinb9f 36
  • 63 (a)
OneToMany
Serpinb9g 36
  • 62 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SERPINB9 35
  • 99.56 (n)
  • 98.94 (a)
SERPINB9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpinb9 35
  • 78.34 (n)
  • 69.79 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6687 37
  • 27 (a)
CG7722 37
  • 28 (a)
CG9455 37
  • 32 (a)
CG9460 37
  • 31 (a)
Spn1 37
  • 34 (a)
Spn2 37
  • 32 (a)
Spn43Aa 37
  • 32 (a)
Spn43Ab 37
  • 27 (a)
Spn5 37
  • 29 (a)
Species with no ortholog for SERPINB9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINB9 Gene

ENSEMBL:
Gene Tree for SERPINB9 (if available)
TreeFam:
Gene Tree for SERPINB9 (if available)

Paralogs for SERPINB9 Gene

Pseudogenes.org Pseudogenes for SERPINB9 Gene

genes like me logo Genes that share paralogs with SERPINB9: view

Variants for SERPINB9 Gene

Sequence variations from dbSNP and Humsavar for SERPINB9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9503331 -- 2,901,758(+) CTCTA(C/T)GCCCA intron-variant, upstream-variant-2KB
rs9503332 -- 2,901,934(+) CCCAG(C/T)CACCC intron-variant, upstream-variant-2KB
rs6916568 -- 2,904,665(+) gcaaa(C/T)tgaat upstream-variant-2KB
rs12192148 -- 2,903,278(+) GGACC(C/G)GGCCC upstream-variant-2KB, utr-variant-5-prime
rs2236275 -- 2,903,347(+) GCAGG(A/G)TCGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SERPINB9 Gene

Variant ID Type Subtype PubMed ID
nsv830575 CNV Loss 17160897
nsv883396 CNV Loss 21882294
nsv348854 CNV Insertion 16902084

Variation tolerance for SERPINB9 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SERPINB9 Gene

Disorders for SERPINB9 Gene

Relevant External Links for SERPINB9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINB9

No disorders were found for SERPINB9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINB9 Gene

Publications for SERPINB9 Gene

  1. Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. (PMID: 8530382) Sprecher C.A. … Kisiel W. (J. Biol. Chem. 1995) 2 3 4 23 67
  2. A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes. (PMID: 9858835) Sun J. … Bird P.I. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  4. Expression of proteinase inhibitor-9/serpinB9 in non-small cell lung carcinoma cells and tissues. (PMID: 19956856) Rousalova I. … Benkova K. (Int. J. Oncol. 2010) 3 23
  5. Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells. (PMID: 18669594) Jiang X. … Shapiro D.J. (Endocrinology 2008) 3 23

Products for SERPINB9 Gene

Sources for SERPINB9 Gene

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