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Aliases for SERPINB9 Gene

Aliases for SERPINB9 Gene

  • Serpin Family B Member 9 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 9 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 2 3
  • Cytoplasmic Antiproteinase 3 3 4
  • Peptidase Inhibitor 9 3 4
  • CAP-3 3 4
  • CAP3 3 4
  • PI-9 3 4
  • PI9 3 4
  • Serpin Peptidase Inhibitor, Clade B, Member 9 3
  • Protease Inhibitor 9 (Ovalbumin Type) 3
  • Testicular Tissue Protein Li 180 3
  • Serpin B9 3

External Ids for SERPINB9 Gene

Previous HGNC Symbols for SERPINB9 Gene

  • PI9

Previous GeneCards Identifiers for SERPINB9 Gene

  • GC06M002872
  • GC06M002832
  • GC06M002760

Summaries for SERPINB9 Gene

Entrez Gene Summary for SERPINB9 Gene

  • This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

GeneCards Summary for SERPINB9 Gene

SERPINB9 (Serpin Family B Member 9) is a Protein Coding gene. Among its related pathways are Amoebiasis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is SERPINB6.

UniProtKB/Swiss-Prot for SERPINB9 Gene

  • Granzyme B inhibitor.

Gene Wiki entry for SERPINB9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB9 Gene

Genomics for SERPINB9 Gene

Regulatory Elements for SERPINB9 Gene

Enhancers for SERPINB9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F002874 1.2 FANTOM5 Ensembl ENCODE 47 +25.2 25218 7.9 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP5 SERPINB9P1 SERPINB9 SERPINB1 ENSG00000232999 NQO2 SERPINB6 LOC105374891 LINC01011 PSMG4 MYLK4
GH06F002872 1 FANTOM5 ENCODE 40.9 +30.6 30632 0.6 RAD51 ETV6 EBF1 KDM1A MNT MGA SERPINB9 ENSG00000232999 SERPINB9P1 SERPINB1 RIPK1 NQO2 PIR60730 PIR43328
GH06F002869 0.8 FANTOM5 Ensembl 40.3 +34.5 34512 0.4 SERPINB9 SERPINB1 SERPINB9P1 ENSG00000232999 NQO2 LINC01011 RIPK1 PIR60730 PIR43328
GH06F002864 1 FANTOM5 Ensembl ENCODE 40.2 +37.4 37368 2.3 ELF3 PKNOX1 ATF1 RARA JUNB TBX21 TGIF2 SP1 NFIL3 IKZF1 SERPINB9 SERPINB1 ENSG00000232999 LINC01011 NQO2 SERPINB9P1 RIPK1 PIR43328 PIR60730
GH06F002885 1.3 FANTOM5 Ensembl 40.1 +17.1 17053 0.9 TFE3 KLF1 SAP130 HLF CEBPB CEBPG RARA IRF9 ZNF766 ATF3 SERPINB9 SERPINB9P1 ENSG00000232999 NQO2 SERPINB6 LINC01011 SERPINB1 RIPK1 LOC101927730
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SERPINB9 on UCSC Golden Path with GeneCards custom track

Promoters for SERPINB9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001209118 512 2401 HDGF ATF1 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF48

Genomic Location for SERPINB9 Gene

Chromosome:
6
Start:
2,887,265 bp from pter
End:
2,903,312 bp from pter
Size:
16,048 bases
Orientation:
Minus strand

Genomic View for SERPINB9 Gene

Genes around SERPINB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB9 Gene

Proteins for SERPINB9 Gene

  • Protein details for SERPINB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50453-SPB9_HUMAN
    Recommended name:
    Serpin B9
    Protein Accession:
    P50453
    Secondary Accessions:
    • B2RBW3
    • Q5TD03

    Protein attributes for SERPINB9 Gene

    Size:
    376 amino acids
    Molecular mass:
    42404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERPINB9 Gene

Post-translational modifications for SERPINB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB9 Gene

No data available for DME Specific Peptides for SERPINB9 Gene

Domains & Families for SERPINB9 Gene

Gene Families for SERPINB9 Gene

Protein Domains for SERPINB9 Gene

Suggested Antigen Peptide Sequences for SERPINB9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50453

UniProtKB/Swiss-Prot:

SPB9_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB9: view

Function for SERPINB9 Gene

Molecular function for SERPINB9 Gene

UniProtKB/Swiss-Prot Function:
Granzyme B inhibitor.

Gene Ontology (GO) - Molecular Function for SERPINB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 16267761
GO:0004867 serine-type endopeptidase inhibitor activity IDA 8910377
GO:0005515 protein binding IPI 17479112
GO:0030414 peptidase inhibitor activity IEA --
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP 17479112
genes like me logo Genes that share ontologies with SERPINB9: view
genes like me logo Genes that share phenotypes with SERPINB9: view

Animal Models for SERPINB9 Gene

MGI Knock Outs for SERPINB9:

Animal Model Products

miRNA for SERPINB9 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINB9 Gene

Localization for SERPINB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB9 Gene COMPARTMENTS Subcellular localization image for SERPINB9 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SERPINB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16267761
GO:0005622 intracellular IDA 21795594
GO:0005634 nucleus IDA 11463822
GO:0005737 cytoplasm IEA,IDA 11463822
GO:0005829 cytosol IDA 11485349
genes like me logo Genes that share ontologies with SERPINB9: view

Pathways & Interactions for SERPINB9 Gene

SuperPathways for SERPINB9 Gene

SuperPathway Contained pathways
1 Amoebiasis
genes like me logo Genes that share pathways with SERPINB9: view

Pathways by source for SERPINB9 Gene

1 KEGG pathway for SERPINB9 Gene

Gene Ontology (GO) - Biological Process for SERPINB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002448 mast cell mediated immunity IEP 15739160
GO:0006915 apoptotic process IEA --
GO:0006955 immune response IDA 16306080
GO:0009617 response to bacterium IDA 22090449
GO:0010466 negative regulation of peptidase activity IEA --
genes like me logo Genes that share ontologies with SERPINB9: view

No data available for SIGNOR curated interactions for SERPINB9 Gene

Drugs & Compounds for SERPINB9 Gene

(4) Drugs for SERPINB9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for SERPINB9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB9: view

Transcripts for SERPINB9 Gene

mRNA/cDNA for SERPINB9 Gene

Unigene Clusters for SERPINB9 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 9:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: -
SP2:

Relevant External Links for SERPINB9 Gene

GeneLoc Exon Structure for
SERPINB9
ECgene alternative splicing isoforms for
SERPINB9

Expression for SERPINB9 Gene

mRNA expression in normal human tissues for SERPINB9 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINB9 Gene

This gene is overexpressed in Nerve - Tibial (x4.9).

Protein differential expression in normal tissues from HIPED for SERPINB9 Gene

This gene is overexpressed in Tlymphocyte (8.5), Peripheral blood mononuclear cells (8.4), Testis (7.1), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SERPINB9 Gene



Protein tissue co-expression partners for SERPINB9 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERPINB9 Gene:

SERPINB9

SOURCE GeneReport for Unigene cluster for SERPINB9 Gene:

Hs.104879
genes like me logo Genes that share expression patterns with SERPINB9: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SERPINB9 Gene

Orthologs for SERPINB9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB9 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia SERPINB9 34 35
  • 78.99 (n)
rat
(Rattus norvegicus)
Mammalia Serpinb9 34
  • 78.34 (n)
mouse
(Mus musculus)
Mammalia Serpinb9 34 16 35
  • 78.25 (n)
Serpinb9b 35
  • 66 (a)
OneToMany
Serpinb9d 35
  • 64 (a)
OneToMany
Serpinb9e 35
  • 63 (a)
OneToMany
Serpinb9f 35
  • 63 (a)
OneToMany
Gm11397 35
  • 62 (a)
OneToMany
Serpinb9g 35
  • 62 (a)
OneToMany
Serpinb9c 35
  • 61 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SERPINB9 34 35
  • 74.15 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Spn1 36
  • 34 (a)
CG9455 36
  • 32 (a)
Spn2 36
  • 32 (a)
Spn43Aa 36
  • 32 (a)
CG9460 36
  • 31 (a)
Spn5 36
  • 29 (a)
CG7722 36
  • 28 (a)
CG6687 36
  • 27 (a)
Spn43Ab 36
  • 27 (a)
Species where no ortholog for SERPINB9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINB9 Gene

ENSEMBL:
Gene Tree for SERPINB9 (if available)
TreeFam:
Gene Tree for SERPINB9 (if available)

Paralogs for SERPINB9 Gene

Variants for SERPINB9 Gene

Sequence variations from dbSNP and Humsavar for SERPINB9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10458067 -- 2,890,880(+) GTTTT(C/T)TTTTC intron-variant
rs1052886 -- 2,889,956(-) GACCA(C/T)AATGA intron-variant, utr-variant-3-prime
rs10714355 -- 2,889,716(+) CTCAG(-/A)AAAAA intron-variant, utr-variant-3-prime
rs111230228 -- 2,901,673(+) CTGAC(C/T)CCTCC intron-variant, upstream-variant-2KB
rs111236932 -- 2,900,574(+) GGCGT(A/G)TGGCA nc-transcript-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SERPINB9 Gene

Variant ID Type Subtype PubMed ID
esv3378500 CNV insertion 20981092
esv3570730 CNV loss 25503493
nsv348854 CNV insertion 16902084
nsv830575 CNV loss 17160897

Variation tolerance for SERPINB9 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINB9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINB9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB9 Gene

Disorders for SERPINB9 Gene

Relevant External Links for SERPINB9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINB9

No disorders were found for SERPINB9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINB9 Gene

Publications for SERPINB9 Gene

  1. Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. (PMID: 8530382) Sprecher C.A. … Kisiel W. (J. Biol. Chem. 1995) 2 3 4 22 64
  2. A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes. (PMID: 9858835) Sun J. … Bird P.I. (Cytogenet. Cell Genet. 1998) 2 3 22 64
  3. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. (PMID: 8910377) Sun J. … Bird P.I. (J. Biol. Chem. 1996) 3 4 22 64
  4. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3 64
  5. Expression of proteinase inhibitor-9/serpinB9 in non-small cell lung carcinoma cells and tissues. (PMID: 19956856) Rousalova I. … Benkova K. (Int. J. Oncol. 2010) 3 22 64

Products for SERPINB9 Gene

Sources for SERPINB9 Gene

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