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Aliases for SERPINB9 Gene

Aliases for SERPINB9 Gene

  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 2 3
  • PI9 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 9 2 3
  • Cytoplasmic Antiproteinase 3 3 4
  • Peptidase Inhibitor 9 3 4
  • CAP-3 3 4
  • CAP3 3 4
  • PI-9 3 4
  • Serpin Peptidase Inhibitor, Clade B, Member 9 3
  • Protease Inhibitor 9 (Ovalbumin Type) 3
  • Serpin B9 3
  • CAP3, 6

External Ids for SERPINB9 Gene

Previous Symbols for SERPINB9 Gene

  • PI9

Summaries for SERPINB9 Gene

Entrez Gene Summary for SERPINB9 Gene

  • This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

GeneCards Summary for SERPINB9 Gene

SERPINB9 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9) is a Protein Coding gene. Among its related pathways are Amoebiasis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB9 Gene

  • Granzyme B inhibitor

Gene Wiki entry for SERPINB9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB9 Gene

Genomics for SERPINB9 Gene

Genomic Location for SERPINB9 Gene

Start:
2,887,265 bp from pter
End:
2,903,312 bp from pter
Size:
16,048 bases
Orientation:
Minus strand

Genomic View for SERPINB9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB9 Gene

Regulatory Elements for SERPINB9 Gene

Proteins for SERPINB9 Gene

  • Protein details for SERPINB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50453-SPB9_HUMAN
    Recommended name:
    Serpin B9
    Protein Accession:
    P50453
    Secondary Accessions:
    • B2RBW3
    • Q5TD03

    Protein attributes for SERPINB9 Gene

    Size:
    376 amino acids
    Molecular mass:
    42404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERPINB9 Gene

Proteomics data for SERPINB9 Gene at MOPED

Post-translational modifications for SERPINB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINB9 Gene

Domains for SERPINB9 Gene

Gene Families for SERPINB9 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINB9 Gene

UniProtKB/Swiss-Prot:

SPB9_HUMAN
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.:
    • P50453
genes like me logo Genes that share domains with SERPINB9: view

Function for SERPINB9 Gene

Molecular function for SERPINB9 Gene

UniProtKB/Swiss-Prot Function: Granzyme B inhibitor

Gene Ontology (GO) - Molecular Function for SERPINB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 16267761
GO:0004867 serine-type endopeptidase inhibitor activity IDA 11485349
GO:0005515 protein binding IPI 17479112
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP 17479112
genes like me logo Genes that share ontologies with SERPINB9: view

Phenotypes for SERPINB9 Gene

genes like me logo Genes that share phenotypes with SERPINB9: view

Animal Models for SERPINB9 Gene

MGI Knock Outs for SERPINB9:

miRNA for SERPINB9 Gene

miRTarBase miRNAs that target SERPINB9

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SERPINB9 Gene

Localization for SERPINB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB9 Gene COMPARTMENTS Subcellular localization image for SERPINB9 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SERPINB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16267761
GO:0005622 intracellular IDA 21795594
GO:0005634 nucleus IDA 11463822
GO:0005737 cytoplasm IDA 11463822
GO:0005829 cytosol IDA 11485349
genes like me logo Genes that share ontologies with SERPINB9: view

Pathways for SERPINB9 Gene

SuperPathways for SERPINB9 Gene

Superpath Contained pathways
1 Amoebiasis
genes like me logo Genes that share pathways with SERPINB9: view

Pathways by source for SERPINB9 Gene

1 KEGG pathway for SERPINB9 Gene

Gene Ontology (GO) - Biological Process for SERPINB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002448 mast cell mediated immunity IEP 15739160
GO:0006955 immune response IDA 16306080
GO:0009617 response to bacterium IDA 22090449
GO:0010628 positive regulation of gene expression IMP 22090449
GO:0010951 negative regulation of endopeptidase activity IMP 21795594
genes like me logo Genes that share ontologies with SERPINB9: view

Compounds for SERPINB9 Gene

(8) Novoseek inferred chemical compound relationships for SERPINB9 Gene

Compound -log(P) Hits PubMed IDs
moxestrol 83.7 2
serine 60.3 9
4-hydroxytamoxifen 58.1 3
raloxifene 48.5 3
tetrapeptide 38.4 1
genes like me logo Genes that share compounds with SERPINB9: view

Transcripts for SERPINB9 Gene

mRNA/cDNA for SERPINB9 Gene

Unigene Clusters for SERPINB9 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: -
SP2:

Relevant External Links for SERPINB9 Gene

GeneLoc Exon Structure for
SERPINB9
ECgene alternative splicing isoforms for
SERPINB9

Expression for SERPINB9 Gene

mRNA expression in normal human tissues for SERPINB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB9 Gene

This gene is overexpressed in Nerve - Tibial (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERPINB9 Gene

SOURCE GeneReport for Unigene cluster for SERPINB9 Gene Hs.104879

genes like me logo Genes that share expressions with SERPINB9: view

Orthologs for SERPINB9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB9 36
  • 99.56 (n)
  • 98.94 (a)
SERPINB9 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINB9 36
  • 74.15 (n)
  • 67.91 (a)
SERPINB9 37
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINB9 36
  • 78.99 (n)
  • 74.47 (a)
SERPINB9 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm11397 37
  • 62 (a)
OneToMany
Serpinb9 36
  • 78.25 (n)
  • 68.98 (a)
Serpinb9 16
Serpinb9 37
  • 69 (a)
OneToMany
Serpinb9b 37
  • 66 (a)
OneToMany
Serpinb9c 37
  • 61 (a)
OneToMany
Serpinb9d 37
  • 64 (a)
OneToMany
Serpinb9e 37
  • 63 (a)
OneToMany
Serpinb9f 37
  • 63 (a)
OneToMany
Serpinb9g 37
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 57 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Serpinb9 36
  • 78.34 (n)
  • 69.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spn43Ab 38
  • 27 (a)
Spn5 38
  • 29 (a)
Spn2 38
  • 32 (a)
Spn43Aa 38
  • 32 (a)
CG9455 38
  • 32 (a)
CG9460 38
  • 31 (a)
CG6687 38
  • 27 (a)
Spn1 38
  • 34 (a)
CG7722 38
  • 28 (a)
Species with no ortholog for SERPINB9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINB9 Gene

ENSEMBL:
Gene Tree for SERPINB9 (if available)
TreeFam:
Gene Tree for SERPINB9 (if available)

Paralogs for SERPINB9 Gene

Pseudogenes.org Pseudogenes for SERPINB9 Gene

genes like me logo Genes that share paralogs with SERPINB9: view

Variants for SERPINB9 Gene

Sequence variations from dbSNP and Humsavar for SERPINB9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs318492 -- 2,902,097(+) TCCAG(A/C)CTCAC intron-variant
rs318493 -- 2,904,557(+) caatt(A/G)ttctc upstream-variant-2KB
rs2236275 -- 2,903,347(+) GCAGG(A/G)TCGGG upstream-variant-2KB
rs2236276 -- 2,903,350(+) GGGTC(A/G)GGCGC upstream-variant-2KB
rs2745398 -- 2,903,695(+) AAGTA(C/G)AAAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SERPINB9 Gene

Variant ID Type Subtype PubMed ID
nsv830575 CNV Loss 17160897
nsv883396 CNV Loss 21882294
nsv348854 CNV Insertion 16902084

Relevant External Links for SERPINB9 Gene

HapMap Linkage Disequilibrium report
SERPINB9

Disorders for SERPINB9 Gene

(9) Novoseek inferred disease relationships for SERPINB9 Gene

Disease -log(P) Hits PubMed IDs
lymphoma large cell 39.2 2
tumors 15.3 12
hodgkin disease 11.1 3
lymphoma 10.2 8
breast cancer 3.17 9
genes like me logo Genes that share disorders with SERPINB9: view

No data available for UniProtKB/Swiss-Prot for SERPINB9 Gene

Publications for SERPINB9 Gene

  1. Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. (PMID: 8530382) Sprecher C.A. … Kisiel W. (J. Biol. Chem. 1995) 2 3 4 23
  2. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. (PMID: 8910377) Sun J. … Bird P.I. (J. Biol. Chem. 1996) 3 4 23
  3. A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes. (PMID: 9858835) Sun J. … Bird P.I. (Cytogenet. Cell Genet. 1998) 2 3 23
  4. Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9. (PMID: 10477277) Annand R.R. … Giegel D.A. (Biochem. J. 1999) 3 23
  5. Chromosomal mapping of the gene (PI9) encoding the intracellular serpin proteinase inhibitor 9 to 6p25 by fluorescence in situ hybridization. (PMID: 8938458) Eyre H.J. … Bird P. (Genomics 1996) 3 23

Products for SERPINB9 Gene

Sources for SERPINB9 Gene

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