Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINB9 Gene

protein-coding   GIFtS: 59
GCID: GC06M002887

serpin peptidase inhibitor, clade B (ovalbumin), member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: PI9)
 Explore 23 diseases affiliated with
SERPINB9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SERPINB9    

Aliases
for SERPINB9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 91 2     CAP-32 3
CAP31 2 3 5     PI-92 3
PI91 2 3 5     Protease Inhibitor 9 (Ovalbumin Type)2
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 91 2     Serpin B92
Cytoplasmic Antiproteinase 32 3     Serpin Peptidase Inhibitor, Clade B, Member 92
Peptidase Inhibitor 92 3     

External Ids:    HGNC: 89551   Entrez Gene: 52722   Ensembl: ENSG000001705427   OMIM: 6017995   UniProtKB: P504533   

Export aliases for SERPINB9 gene to outside databases

Previous GC identifers: GC06M002872 GC06M002832 GC06M002760


Summaries
for SERPINB9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SERPINB9:
This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein
belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme
B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A
pseudogene of this gene is found on chromosome 6. (provided by RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: SPB9_HUMAN, P50453
Function: Granzyme B inhibitor

Gene Wiki entry for SERPINB9


Genomic Views
for SERPINB9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINB9 gene promoter:
         TBP   MEF-2   MEF-2A   TFIID   FOXJ2 (long isoform)   FOXO1a   SEF-1 (1)   aMEF-2   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SERPINB9 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINB9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25.2

SERPINB9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB9 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M002887:  view genomic region     (about GC identifiers)

Start:
 2,887,500 bp from pter      End:
 2,903,545 bp from pter
Size:
 16,046 bases      Orientation:
 minus strand

Proteins
for SERPINB9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPB9_HUMAN, P50453 (See protein sequence)
Recommended Name: Serpin B9  
Size: 376 amino acids; 42404 Da
Subcellular location: Cytoplasm
Secondary accessions: B2RBW3 Q5TD03

Explore the universe of human proteins at neXtProt for SERPINB9: NX_P50453

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P50453

    • SERPINB9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004146.1  
    ENSEMBL proteins: 
     ENSP00000370074  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SERPINB9
    OriGene Protein Over-expression Lysate: SERPINB9
    OriGene Custom Protein Services for SERPINB9 
    GenScript Custom Purified and Recombinant Proteins Services for SERPINB9
    Novus Biologicals SERPINB9 Proteins
    Novus Biologicals SERPINB9 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SERPINB9

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA16267761
    GO:0005634nucleus IDA11485349
    GO:0005737cytoplasm IDA15739160
    GO:0005829cytosol IDA11485349


    SERPINB9 for ontologies           About GeneDecksing



    SERPINB9 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: SERPINB9
    OriGene Custom Antibody Services for SERPINB9 
    GenScript Custom Superior Antibodies Services for SERPINB9
    Novus Biologicals SERPINB9 Antibodies
    Abcam antibodies for SERPINB9 
    Uscn Antibodies for SERPINB9
    ThermoFisher Antibodies for SERPINB9

    Assay Products for SERPINB9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SERPINB9
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SERPINB9

    Protein Domains /
    Families
    for SERPINB9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SERPINB9 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000240 Serpin_B9/Maspin
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P50453

    ProtoNet protein and cluster: P50453

    2 Blocks protein families:
    IPB000215 Serpin
    IPB000240 Maspin signature


    UniProtKB/Swiss-Prot: SPB9_HUMAN, P50453
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    Function
    for SERPINB9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPB9_HUMAN, P50453
    Function: Granzyme B inhibitor

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SERPINB9
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB9
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINB9:
    hsa-miR-539 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SERPINB9 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB9 (see all 7)
    OriGene shRNA RFP: SERPINB9
    OriGene siRNA: SERPINB9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB9

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SERPINB9

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB9 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB9
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SERPINB9 (NM_004155)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB9 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SERPINB9
    Search LifeMap BioReagents cell lines for SERPINB9

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB9

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI16267761
    GO:0004867serine-type endopeptidase inhibitor activity IDA8910377
    GO:0005515protein binding IPI17479112
    GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP17479112


    SERPINB9 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SERPINB9:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Serpinb9tm1Arp for SERPINB9
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Serpinb9):
     cellular  hematopoietic system  homeostasis/metabolism  immune system 

    SERPINB9 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SERPINB9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amoebiasis
    		Amoebiasis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for SERPINB9):
        Amoebiasis


    SERPINB9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINB9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/39 Interacting proteins for SERPINB9 (P504532, 3 ENSP000003700744) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAPDHP044062, 3, ENSP000002292394MINT-63813 I2D: score=5 STRING: ENSP00000229239
    BRD7Q9NPI12, 3MINT-63831 I2D: score=5 
    C14orf1Q9UKR52, 3MINT-63832 I2D: score=5 
    CCDC90BQ9GZT62, 3MINT-63828 I2D: score=5 
    COPS6Q7L5N12, 3MINT-63823 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002448mast cell mediated immunity IEP15739160
    GO:0006955immune response IDA16306080
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--
    GO:0043066negative regulation of apoptotic process IMP17237823


    SERPINB9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SERPINB9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINB9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINB9
    8 Novoseek chemical compound relationships for SERPINB9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    moxestrol 83.7 3 14617632 (2)
    serine 60.3 11 15128837 (2), 11856484 (1), 10556578 (1), 14729651 (1) (see all 8)
    4-hydroxytamoxifen 58.1 5 10681578 (1), 18669594 (1), 14617632 (1)
    raloxifene 48.5 6 17237823 (1), 18669594 (1), 14617632 (1)
    tetrapeptide 38.4 1 10477277 (1)
    estrogen 26.5 30 10681578 (5), 17237823 (5), 11682627 (3), 16306080 (3) (see all 7)
    cycloheximide 12.4 3 10681578 (1), 16487253 (1)
    tamoxifen 10.8 8 17237823 (2), 17490628 (1)

    Search CenterWatch for drugs/clinical trials and news about SERPINB9 / SPB9 

    Transcripts
    for SERPINB9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SERPINB9 gene: 
    NM_004155.5  

    Unigene Cluster for SERPINB9:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 9
    Hs.104879  [show with all ESTs]
    Unigene Representative Sequence: NM_004155
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380698(uc003muf.3 uc003mug.3 uc003muh.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SERPINB9
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB9
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINB9:
    hsa-miR-539 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SERPINB9 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB9 (see all 7)
    OriGene shRNA RFP: SERPINB9
    OriGene siRNA: SERPINB9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB9
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB9 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB9
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SERPINB9 (NM_004155)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB9 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB9
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERPINB9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB9

    Additional cDNA sequence: 

    AB060690.1 AK314842.1 AY927513.1 BC002538.2 BT006673.1 BX640606.1 CR407627.1 L40378.1 
    U71364.1 

    11 DOTS entries:

    DT.100751046  DT.95269320  DT.100659231  DT.100751047  DT.100759181  DT.100777552  DT.106085  DT.97787939 
    DT.40188731  DT.102828835  DT.40281138 

    24/136 AceView cDNA sequences (see all 136):

    BT006673 BQ061375 CR407627 BG236422 L40378 CR613727 BF513799 CR616287 
    BU509026 AA709293 BX446545 AA368555 CK904427 BX506490 BM023157 CD520974 
    CD643312 BQ029632 BM996560 NM_004155 BM955982 AL049245 BG029349 AL045841 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB9    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
    SP1:                                            -               
    SP2:                                                            


    ECgene alternative splicing isoforms for SERPINB9

    Expression
    for SERPINB9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINB9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATCAACACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SERPINB9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Definitive Endoderm (Generation of beta c...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SERPINB9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINB9

    SOURCE GeneReport for Unigene cluster: Hs.104879
        SABiosciences Expression via Pathway-Focused PCR Array including SERPINB9: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB9
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERPINB9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB9
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB9

    Orthologs
    for SERPINB9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINB9 gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1P1L8_CHICK6
    		 serine (or cysteine) proteinase inhibitor, clade B...
    		 54(a)
    		 1 → many
    		 2(68854258-68863717)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 46(a)
    		 1 → many
    		 GL343311.1(705019-715600)
    zebrafish
    (Danio rerio)    		 Actinopterygii serpinb1l16
    si:ch73-303g23.46
    (see all 5)    		 si:ch73-303g23.4
    (see all 5)    		 50(a)
    46(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 16(54874440-54879870)
    16(54891752-54902149)


    ENSEMBL Gene Tree for SERPINB9 (if available)
    TreeFam Gene Tree for SERPINB9 (if available) 

    Paralogs
    for SERPINB9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINB9 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB32  SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINE12  SERPINE32  SERPINB132  
    SERPINB82  
    18/32 SIMAP similar genes for SERPINB9 using alignment to 1 protein entry:     SPB9_HUMAN(see all similar genes):
    DKFZp686O07189    SERPINB8    SERPINB6    SERPINB1    SERPINB10    SERPINB3
    SERPINB12    SERPINB5    SERPINB11    SERPINB2    SERPINB13    SERPINB4
    SCCA2    SERPINA9    SERPINB7    SERPINA12    SERPINA5    SERPINI1

    SERPINB9 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SERPINB9
    PGOHUM00000243041


    Genomic Variants
    for SERPINB9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/387 NCBI SNPs in SERPINB9 are shown (see all 387)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs3184741,2
    		C,F,A,H,--2887040(+) TAGGAT/CTTATA 1 -- ds500112Minor allele frequency- C:0.48NS NA WA EA 466
    rs2230411,2
    		C,F,A,H,--2887047(+) TATATG/TGAAAA 1 -- ds50019Minor allele frequency- T:0.13EA NS NA WA 526
    rs1500704291,2
    		C,--2887059(+) AACTC-/AAAAAA 1 -- ds50010--------
    rs728386791,2
    		C,--2887085(+) GTAGTG/ATAGAA 1 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs1445542981,2
    		C,--2887130(+) CCTTA-/ATGAG 
                ATGAC     		1 -- ds50010--------
    rs721730361,2
    		C,--2887134(+) AATGA-/GATGACTA 1 -- ds50010--------
    rs3184751,2
    		C,F,A,H,--2887261(+) CTAAAA/GTTCAC 1 -- ds500119Minor allele frequency- G:0.45NS EA NA WA 1008
    rs1843266441,2
    		--2887370(+) TTCCAA/TGTGAA 1 -- ds50010--------
    rs3184761,2
    		C,A,H,--2887409(+) TTAGAA/GAAAAA 1 -- ds50016Minor allele frequency- G:0.46NA WA EA 364
    rs1876880151,2
    		--2887417(+) AAAACG/TATTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SERPINB9 (2887500 - 2903545 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SERPINB9: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINB9
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINB9

    Disorders / Diseases
    for SERPINB9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SERPINB9 for disorders           About GeneDecksing

    OMIM gene information: 601799    OMIM disorders: --

    20/23 diseases for SERPINB9 (see all 23):    About MalaCards
    diffuse large b-cell lymphoma    non-small cell lung carcinoma    b-cell lymphomas    anaplastic large cell lymphoma
    eosinophilic pneumonia    chronic eosinophilic pneumonia    cytomegalovirus infection    acute lymphoblastic leukemia
    lymphoblastic leukemia    hodgkin's lymphoma    lung carcinoma    pneumonia
    breast cancer    leukemia    choroiditis    nasopharyngitis
    melanoma    sarcoma    carcinoma    retinitis

    9 Novoseek disease relationships for SERPINB9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma large cell 39.2 2 11756176 (1), 14712286 (1)
    tumors 15.3 14 11756176 (3), 17077322 (2), 11562487 (1), 16144945 (1) (see all 9)
    hodgkin disease 11.1 3 11756176 (2), 14712286 (1)
    lymphoma 10.2 10 16373664 (5), 11756176 (2), 17077322 (1)
    breast cancer 3.17 11 18669594 (6), 17237823 (2), 17490628 (1)
    leukemia 0 3 15531453 (1), 8910377 (1)
    shock 0 1 12748950 (1)
    inflammation 0 2 12177049 (1)
    cancer 0 4 11856484 (3), 19956856 (1)


    Export disorders for SERPINB9 gene to outside databases

    Publications
    for SERPINB9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINB9 gene, integrated from 9 sources (see all 85):
    (articles sorted by number of sources associating them with SERPINB9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. (PubMed id 8530382)1, 2, 3, 9 Sprecher C.A.... Kisiel W. (1995)
    2. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. (PubMed id 8910377)1, 2, 9 Sun J.... Bird P.I. (1996)
    3. A serpin gene cluster on human chromosome 6p25 contai ns PI6, PI9 and ELANH2 which have a common structure almost identical to the 18 q21 ovalbumin serpin genes. (PubMed id 9858835)1, 3, 9 Sun J....Bird P.I. (1998)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The granzyme B inhibitor, PI-9, is differentially expressed during placental development and up-regulated in hydatidiform moles. (PubMed id 16310039)1, 9 Buzza M.S....Bird P.I. (2006)
    6. The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias. (PubMed id 15531453)1, 9 Classen C.F....Debatin K.M. (2004)
    7. Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells. (PubMed id 10681578)1, 9 Kanamori H....Shapiro D.J. (2000)
    8. Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells. (PubMed id 18669594)1, 9 Jiang X....Shapiro D.J. (2008)
    9. The granzyme B inhibitor proteinase inhibitor 9 (PI9) is expressed by human mast cells. (PubMed id 15739160)1, 9 Bladergroen B.A....Hack C.E. (2005)
    10. The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. (PubMed id 12517944)1, 9 Hirst C.E....Bird P.I. (2003)

    External Searches for SERPINB9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SERPINB9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5272 HGNC: 8955 AceView: SERPINB9 Ensembl:ENSG00000170542 euGenes: HUgn5272
    ECgene: SERPINB9 Kegg: 5272 H-InvDB: SERPINB9

    Other Databases showing SERPINB9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SERPINB9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINB9 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SERPINB9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SERPINB9 gene:
    Search GeneIP for patents involving SERPINB9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SERPINB9 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for SERPINB9   OriGene shRNA RFP for SERPINB9  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB9   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB9  
     OriGene Protein Over-expression Lysate for SERPINB9   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SERPINB9   OriGene 3'-UTR Clone for SERPINB9  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB9   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB9  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SERPINB9   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SERPINB9   OriGene Custom Protein Services for SERPINB9  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERPINB9
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINB9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB9
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB9
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB9
     GenScript Custom Purified and Recombinant Proteins Services for SERPINB9 GenScript cDNA clones with any tag delivered in your preferred vector for SERPINB9
     GenScript Custom Assay Services for SERPINB9 GenScript Custom Superior Antibodies Services for SERPINB9
     GenScript Custom overexpressing Cell Line Services for SERPINB9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SERPINB9 promoter
     Search Chromatin IP Primers for SERPINB9
     RT2 qPCR Primer Assay in human, mouse, rat SERPINB9
     GNC Network for SERPINB9
     SABiosciences PCR Arrays including human, mouse, rat SERPINB9
     Search Tocris compounds for SERPINB9
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SERPINB9 antibodies
     SERPINB9 proteins
     SERPINB9 lysates
     Antibodies for SERPINB9
     See all of Abcam's Antibodies, Kits and Proteins for SERPINB9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SERPINB9 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SERPINB9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB9
     SwitchGear 3'UTR luciferase reporter plasmids for SERPINB9
     SwitchGear Promoter luciferase reporter plasmids for SERPINB9
     ThermoFisher Antibodies for SERPINB9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB9
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SERPINB9 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4