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SERPINB9 Gene

protein-coding   GIFtS: 59
GCID: GC06M002887

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: PI9)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 91 2     CAP-32 3
PI91 2 3 5     PI-92 3
CAP32 3 5     Protease Inhibitor 9 (Ovalbumin Type)2
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 91 2     Serpin B92
Cytoplasmic Antiproteinase 32 3     Serpin Peptidase Inhibitor, Clade B, Member 92
Peptidase Inhibitor 92 3     

External Ids:    HGNC: 89551   Entrez Gene: 52722   Ensembl: ENSG000001705427   OMIM: 6017995   UniProtKB: P504533   

Export aliases for SERPINB9 gene to outside databases

Previous GC identifers: GC06M002872 GC06M002832 GC06M002760


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SERPINB9 Gene:
This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded
protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector
molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain
tumor cells. A pseudogene of this gene is found on chromosome 6. (provided by RefSeq, Mar 2012)

GeneCards Summary for SERPINB9 Gene:
SERPINB9 (serpin peptidase inhibitor, clade B (ovalbumin), member 9) is a protein-coding gene. Diseases associated with SERPINB9 include chronic eosinophilic pneumonia, and eosinophilic pneumonia. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: SPB9_HUMAN, P50453
Function: Granzyme B inhibitor

Gene Wiki entry for SERPINB9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERPINB9 gene promoter:
         TBP   MEF-2   MEF-2A   TFIID   FOXJ2 (long isoform)   FOXO1a   SEF-1 (1)   aMEF-2   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SERPINB9 promoter sequence
   Search Chromatin IP Primers for SERPINB9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERPINB9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25.2

SERPINB9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB9 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M002887:  view genomic region     (about GC identifiers)

Start:
2,887,500 bp from pter      End:
2,903,545 bp from pter
Size:
16,046 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SPB9_HUMAN, P50453 (See protein sequence)
Recommended Name: Serpin B9  
Size: 376 amino acids; 42404 Da
Secondary accessions: B2RBW3 Q5TD03

Explore the universe of human proteins at neXtProt for SERPINB9: NX_P50453

Explore proteomics data for SERPINB9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SERPINB9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004146.1  
    ENSEMBL proteins: 
     ENSP00000370074  

    SERPINB9 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

    SERPINB9 Antibody Products:

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    Abcam antibodies for SERPINB9
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    ThermoFisher Antibodies for SERPINB9
    LSBio Antibodies in human, mouse, rat for SERPINB9

    SERPINB9 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SERPIN: Serine (or cysteine) peptidase inhibitors

    4 InterPro protein domains:
     IPR000240 Serpin_B9/Maspin
     IPR023795 Serpin_CS
     IPR000215 Serpin_fam
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry P50453

    ProtoNet protein and cluster: P50453

    2 Blocks protein domains:
    IPB000215 Serpin
    IPB000240 Maspin signature


    UniProtKB/Swiss-Prot: SPB9_HUMAN, P50453
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    SERPINB9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPB9_HUMAN, P50453
    Function: Granzyme B inhibitor

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI16267761
    GO:0004867serine-type endopeptidase inhibitor activity IDA11485349
    GO:0005515protein binding IPI17479112
    GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP17479112
         
    SERPINB9 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERPINB9:
     G0/1 arrest  Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Serpinb9):
     cellular  hematopoietic system  homeostasis/metabolism  immune system 

    SERPINB9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Serpinb9tm1Arp for SERPINB9

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERPINB9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SERPINB9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINB9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERPINB9

    miRNA
    Products:
        
    miRTarBase miRNAs that target SERPINB9:
    hsa-mir-335-5p (MIRT018626)

    Block miRNA regulation of human, mouse, rat SERPINB9 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SERPINB9:
    hsa-miR-539 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidSERPINB9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SERPINB9
    Predesigned siRNA for gene silencing in human, mouse, rat SERPINB9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SERPINB9

    Clone
    Products:
         
    OriGene clones in human, mouse for SERPINB9 (see all 6)
    OriGene ORF clones in mouse, rat for SERPINB9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SERPINB9 (NM_004155)
    Sino Biological Human cDNA Clone for SERPINB9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB9

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SERPINB9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPB9_HUMAN, P50453: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular5
    nucleus5
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA16267761
    GO:0005634nucleus IDA11463822
    GO:0005737cytoplasm IDA11463822
    GO:0005829cytosol IDA11485349
    GO:0070062extracellular vesicular exosome IDA--

    SERPINB9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SERPINB9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Amoebiasis
    Amoebiasis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for SERPINB9):
        Amoebiasis


    SERPINB9 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SERPINB9: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SERPINB9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SERPINB9 (P504532, 3 ENSP000003700744) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAPDHP044062, 3, ENSP000002292394MINT-63813 I2D: score=5 STRING: ENSP00000229239
    BRD7Q9NPI12, 3MINT-63831 I2D: score=5 
    C14orf1Q9UKR52, 3MINT-63832 I2D: score=5 
    CCDC90BQ9GZT62, 3MINT-63828 I2D: score=5 
    COPS6Q7L5N12, 3MINT-63823 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002448mast cell mediated immunity IEP15739160
    GO:0006955immune response IDA16306080
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--
    GO:0043066negative regulation of apoptotic process IMP17237823

    SERPINB9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERPINB9 (SPB9)

    8 Novoseek inferred chemical compound relationships for SERPINB9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    moxestrol 83.7 3 14617632 (2)
    serine 60.3 11 15128837 (2), 11856484 (1), 10556578 (1), 14729651 (1) (see all 8)
    4-hydroxytamoxifen 58.1 5 10681578 (1), 18669594 (1), 14617632 (1)
    raloxifene 48.5 6 17237823 (1), 18669594 (1), 14617632 (1)
    tetrapeptide 38.4 1 10477277 (1)
    estrogen 26.5 30 10681578 (5), 17237823 (5), 11682627 (3), 16306080 (3) (see all 7)
    cycloheximide 12.4 3 10681578 (1), 16487253 (1)
    tamoxifen 10.8 8 17237823 (2), 17490628 (1)



    SERPINB9 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SERPINB9 gene: 
    NM_004155.5  

    Unigene Cluster for SERPINB9:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 9
    Hs.104879  [show with all ESTs]
    Unigene Representative Sequence: NM_004155
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380698(uc003muf.3 uc003mug.3 uc003muh.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SERPINB9 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SERPINB9:
    hsa-miR-539 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidSERPINB9 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SERPINB9
    Predesigned siRNA for gene silencing in human, mouse, rat SERPINB9
    Clone
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    OriGene clones in human, mouse for SERPINB9 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SERPINB9 (NM_004155)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB9
    Primer
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    OriGene qPCR primer pairs and template standards for SERPINB9
    OriGene qSTAR qPCR primer pairs in human, mouse for SERPINB9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERPINB9
      QuantiTect SYBR Green Assays in human, mouse, rat SERPINB9
      QuantiFast Probe-based Assays in human, mouse, rat SERPINB9

    Additional mRNA sequence: 

    AB060690.1 AK314842.1 AY927513.1 BC002538.2 BT006673.1 BX640606.1 CR407627.1 L40378.1 
    U71364.1 

    11 DOTS entries:

    DT.100751046  DT.95269320  DT.100659231  DT.100751047  DT.100759181  DT.100777552  DT.106085  DT.97787939 
    DT.40188731  DT.102828835  DT.40281138 

    Selected AceView cDNA sequences (see all 136):

    CR616287 BF513799 CR407627 BQ061375 CR613727 L40378 BU509026 BT006673 
    BG236422 AL049245 BE279919 BX952279 CF994840 AA632416 AB060690 AI199860 
    AI653230 BC002538 NM_004155 CB994941 AI650687 AA709293 BX411689 AA885793 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB9    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
    SP1:                                            -               
    SP2:                                                            


    ECgene alternative splicing isoforms for SERPINB9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERPINB9 expression in normal human tissues (normalized intensities)      SERPINB9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCAACACT
    SERPINB9 Expression
    About this image


    SERPINB9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Placenta (Extraembryonic Tissues)
    SERPINB9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERPINB9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.104879
        Pathway & Disease-focused RT2 Profiler PCR Array including SERPINB9: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SERPINB9
    OriGene qSTAR qPCR primer pairs in human, mouse for SERPINB9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERPINB9
    QuantiTect SYBR Green Assays in human, mouse, rat SERPINB9
    QuantiFast Probe-based Assays in human, mouse, rat SERPINB9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SERPINB9 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpinb91 , 5 serine (or cysteine) peptidase inhibitor, clade B, more1, 5 78.25(n)1
    68.98(a)1
      13 (13.79 cM)5
    207231  NM_009256.31  NP_033282.11 
     330032505 


    ENSEMBL Gene Tree for SERPINB9 (if available)
    TreeFam Gene Tree for SERPINB9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERPINB9 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB32  SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINE12  SERPINB112  SERPINE32  
    SERPINB132  SERPINB82  
    Selected SIMAP similar genes for SERPINB9 using alignment to 1 protein entry:     SPB9_HUMAN(see all similar genes):
    DKFZp686O07189    SERPINB8    SERPINB6    SERPINB1    SERPINB10    SERPINB3
    SERPINB12    SERPINB5    SERPINB11    SERPINB2    SERPINB13    SERPINB4
    SCCA2    SERPINA9    SERPINB7    SERPINA12    SERPINA5    SERPINI1

    SERPINB9 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SERPINB9
    PGOHUM00000243041


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERPINB9 (see all 496)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3184741,2
    C,F,A,H--2887040(+) TAGGAT/CTTATA 1 -- ds500112Minor allele frequency- C:0.48NS NA WA EA 466
    rs2230411,2
    C,F,A,H--2887047(+) TATATG/TGAAAA 1 -- ds50019Minor allele frequency- T:0.13EA NS NA WA 526
    rs1500704291,2
    C--2887059(+) AACTC-/AAAAAA 1 -- ds50010--------
    rs728386791,2
    C,F--2887085(+) GTAGTG/ATAGAA 1 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs1445542981,2
    C--2887130(+) CCTTA-/ATGAG 
            
    ATGAC
    1 -- ds50010--------
    rs580976411,2
    C--2887134(+) AATGA-/GATGA 
            
    CTAAA
    1 -- ds50010--------
    rs721730361,2
    C--2887134(+) AATGA-/GATGACTA 1 -- ds50010--------
    rs559684361,2
    C--2887136(+) TGAGA-/TGACTAAA 1 -- ds50010--------
    rs3184751,2
    C,F,A,H--2887261(+) CTAAAA/GTTCAC 1 -- ds500119Minor allele frequency- G:0.45NS EA NA WA 1008
    rs1843266441,2
    --2887370(+) TTCCAA/TGTGAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SERPINB9 (2887500 - 2903545 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SERPINB9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv348854CNV Insertion16902084
    nsv883396CNV Loss21882294
    nsv830575CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601799    OMIM disorders: --

    Selected diseases for SERPINB9 (see all 24):    About MalaCards
    chronic eosinophilic pneumonia    eosinophilic pneumonia    pneumonia    cytomegalovirus infection
    anaplastic large cell lymphoma    diffuse large b-cell lymphoma    b-cell lymphomas    choroiditis
    nasopharyngitis    lymphoblastic leukemia    hodgkin's lymphoma    tuberculosis
    retinitis    leukemia    endotheliitis    breast cancer
    sarcoma    melanoma    lung cancer    adenocarcinoma


    SERPINB9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    9 Novoseek inferred disease relationships for SERPINB9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma large cell 39.2 2 11756176 (1), 14712286 (1)
    tumors 15.3 14 11756176 (3), 17077322 (2), 11562487 (1), 16144945 (1) (see all 9)
    hodgkin disease 11.1 3 11756176 (2), 14712286 (1)
    lymphoma 10.2 10 16373664 (5), 11756176 (2), 17077322 (1)
    breast cancer 3.17 11 18669594 (6), 17237823 (2), 17490628 (1)
    leukemia 0 3 15531453 (1), 8910377 (1)
    shock 0 1 12748950 (1)
    inflammation 0 2 12177049 (1)
    cancer 0 4 11856484 (3), 19956856 (1)


    Export disorders for SERPINB9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERPINB9 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with SERPINB9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. (PubMed id 8530382)1, 2, 3, 9 Sprecher C.A.... Kisiel W. (J. Biol. Chem. 1995)
    2. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. (PubMed id 8910377)1, 2, 9 Sun J.... Bird P.I. (J. Biol. Chem. 1996)
    3. A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes. (PubMed id 9858835)1, 3, 9 Sun J....Bird P.I. (Cytogenet. Cell Genet. 1998)
    4. Update of the human and mouse SERPIN gene superfamily. (PubMed id 24172014)1, 3 Heit C....Vasiliou V. (Hum. Genomics 2013)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The granzyme B inhibitor, PI-9, is differentially expressed during placental development and up-regulated in hydatidiform moles. (PubMed id 16310039)1, 9 Buzza M.S....Bird P.I. (Placenta 2006)
    7. The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias. (PubMed id 15531453)1, 9 Classen C.F....Debatin K.M. (Haematologica 2004)
    8. Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells. (PubMed id 10681578)1, 9 Kanamori H....Shapiro D.J. (J. Biol. Chem. 2000)
    9. Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells. (PubMed id 18669594)1, 9 Jiang X....Shapiro D.J. (Endocrinology 2008)
    10. The granzyme B inhibitor proteinase inhibitor 9 (PI9) is expressed by human mast cells. (PubMed id 15739160)1, 9 Bladergroen B.A....Hack C.E. (Eur. J. Immunol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5272 HGNC: 8955 AceView: SERPINB9 Ensembl:ENSG00000170542 euGenes: HUgn5272
    ECgene: SERPINB9 Kegg: 5272 H-InvDB: SERPINB9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERPINB9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERPINB9 gene:
    Search GeneIP for patents involving SERPINB9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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