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SERPINB8 Gene

protein-coding   GIFtS: 59
GCID: GC18P061637

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: PI8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 81 2     Peptidase Inhibitor 82 3
PI81 2 3 5     PI-82 3
Cytoplasmic Antiproteinase 21 2 3     Protease Inhibitor 8 (Ovalbumin Type)2
CAP22 3 5     Serpin B82
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 81 2     CAP-23

External Ids:    HGNC: 89521   Entrez Gene: 52712   Ensembl: ENSG000001664017   OMIM: 6016975   UniProtKB: P504523   

Export aliases for SERPINB8 gene to outside databases

Previous GC identifers: GC18P061476 GC18P061610 GC18P061422 GC18P059786 GC18P059295 GC18P059788 GC18P058338


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SERPINB8 Gene:
The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of
intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular
differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a
tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 (PubMed
2690952)). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease
inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1
(MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal
extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate
position (summary by Bartuski et al., 1997 (PubMed 9268635)).(supplied by OMIM, Jan 2010)

GeneCards Summary for SERPINB8 Gene:
SERPINB8 (serpin peptidase inhibitor, clade B (ovalbumin), member 8) is a protein-coding gene. Diseases associated with SERPINB8 include kimura disease, and neuroendocrine tumor. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB7.

Gene Wiki entry for SERPINB8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERPINB8 gene promoter:
         RP58   POU3F1   NF-E2 p45   Tal-1beta   YY1   E47   MEF-2A   aMEF-2   Msx-1   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINB8 promoter sequence
   Search Chromatin IP Primers for SERPINB8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERPINB8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.1   Ensembl cytogenetic band:  18q22.1   HGNC cytogenetic band: 18q22.1

SERPINB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB8 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P061637:  view genomic region     (about GC identifiers)

Start:
61,637,159 bp from pter      End:
61,672,278 bp from pter
Size:
35,120 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SPB8_HUMAN, P50452 (See protein sequence)
Recommended Name: Serpin B8  
Size: 374 amino acids; 42767 Da
Secondary accessions: Q7Z2V6 Q8N178
Alternative splicing: 2 isoforms:  P50452-1   P50452-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SERPINB8: NX_P50452

Explore proteomics data for SERPINB8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SERPINB8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001027018.1  NP_001263419.1  NP_002631.3  NP_942130.1  

    ENSEMBL proteins: 
     ENSP00000381072   ENSP00000381075   ENSP00000414580   ENSP00000393456   ENSP00000295211  
     ENSP00000331368   ENSP00000438328  
    Reactome Protein details: P50452

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Serpin_CS
     IPR000215 Serpin_fam
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry P50452

    ProtoNet protein and cluster: P50452

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: SPB8_HUMAN, P50452
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    SERPINB8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IDA8530382
    GO:0005515protein binding IPI8530382
         
    SERPINB8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SERPINB8:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERPINB8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SERPINB8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINB8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERPINB8

    miRNA
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    Block miRNA regulation of human, mouse, rat SERPINB8 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SERPINB8:
    hsa-miR-607 hsa-miR-3688-3p hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidSERPINB8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SERPINB8
    Predesigned siRNA for gene silencing in human, mouse, rat SERPINB8

    Gene Editing
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    Sino Biological Human cDNA Clone for SERPINB8
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    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPB8_HUMAN, P50452: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular2
    golgi apparatus1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005829cytosol IDA8530382

    SERPINB8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SERPINB8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Dissolution of Fibrin Clot
    Dissolution of Fibrin Clot
    3CFTR dependent regulation of ion channels in Airway Epithelium norm and CF
    CFTR dependent regulation of ion channels in Airway Epithelium norm and CF

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for SERPINB8
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)


    1 Reactome Pathway for SERPINB8
        Dissolution of Fibrin Clot



    SERPINB8 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERPINB8
    Interactions:

        GeneGlobe Interaction Network for SERPINB8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SERPINB8 (P504523 ENSP000003313684) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FURINP099583, ENSP000002681714I2D: score=3 STRING: ENSP00000268171
    BCL2P104153, ENSP000003296234I2D: score=1 STRING: ENSP00000329623
    F2P007343, ENSP000003085414I2D: score=1 STRING: ENSP00000308541
    F10P007423, ENSP000003647094I2D: score=2 STRING: ENSP00000364709
    PRSS1P074773, ENSP000003087204I2D: score=2 STRING: ENSP00000308720
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity IDA8530382
    GO:0030162regulation of proteolysis IBA--

    SERPINB8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERPINB8 (SPB8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SERPINB8 gene (4 alternative transcripts): 
    NM_001031848.1  NM_001276490.1  NM_002640.3  NM_198833.1  

    Unigene Cluster for SERPINB8:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 8
    Hs.368077  [show with all ESTs]
    Unigene Representative Sequence: NM_198833
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397985(uc002lju.3 uc010xex.2) ENST00000397988(uc002ljt.3)
    ENST00000448851 ENST00000441827(uc002ljs.1) ENST00000295211 ENST00000493661
    ENST00000353706(uc002ljv.3) ENST00000542677
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate SERPINB8:
    hsa-miR-607 hsa-miR-3688-3p hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidSERPINB8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SERPINB8
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB8
    Primer
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    OriGene qPCR primer pairs and template standards for SERPINB8
    OriGene qSTAR qPCR primer pairs in human, mouse for SERPINB8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERPINB8
      QuantiTect SYBR Green Assays in human, mouse, rat SERPINB8
      QuantiFast Probe-based Assays in human, mouse, rat SERPINB8

    Additional mRNA sequence: 

    AK300391.1 AK313782.1 BC034528.1 BX571754.1 DQ656055.2 L40377.1 U92984.1 

    5 DOTS entries:

    DT.209901  DT.95269447  DT.95269448  DT.92004519  DT.303141 

    Selected AceView cDNA sequences (see all 66):

    AA972628 CK904586 AL711105 AA360401 NM_198833 CF130399 BC034528 CK904587 
    CB122815 NM_002640 BM696260 BQ003005 AL597104 AL121194 AI095851 BM991416 
    BG499418 AI925897 AA373798 W61361 U92984 CD369662 BI756040 BQ435307 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERPINB8 expression in normal human tissues (normalized intensities)      SERPINB8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTGTTGAT
    SERPINB8 Expression
    About this image


    SERPINB8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    SERPINB8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERPINB8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368077
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINB8 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpinb81 , 5 serine (or cysteine) peptidase inhibitor, clade B, more1, 5 81.11(n)1
    78.34(a)1
      1 (50.34 cM)5
    207251  NM_011459.41  NP_035589.11 
     1075900065 
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054232.12   -- 73.33(n)    BC054232.1 


    ENSEMBL Gene Tree for SERPINB8 (if available)
    TreeFam Gene Tree for SERPINB8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERPINB8 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB32  SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINB112  
    SERPINE32  SERPINB132  
    Selected SIMAP similar genes for SERPINB8 using alignment to 5 protein entries:     SPB8_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O07189    SERPINB9    SERPINB6    PLANH2    HMSD    SCCA1
    SERPINB1    SERPINB10    SERPINB3    SERPINB12    SERPINB11    DKFZp686D06190
    SERPINB4    SCCA2    SERPINB5    SERPINC1    SERPINA1    AT3

    SERPINB8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SERPINB8
    PGOHUM00000243470


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERPINB8 (see all 543)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs744724451,2
    C,F--61635298(+) CTTTGA/TTTCTT 4 -- us2k12Minor allele frequency- T:0.06NA EA 122
    rs6095441,2
    H--61635314(-) AGGAAG/CAGGGA 4 -- us2k1 trp34Minor allele frequency- C:0.00NS EA 402
    rs1818598981,2
    --61635352(+) TTATGC/TCCTGG 4 -- us2k10--------
    rs617445681,2
    C,F--61635387(+) TCTCCA/TTTTCT 4 -- us2k13Minor allele frequency- T:0.27NS WA NA 316
    rs1496496761,2
    --61635430(+) TCTCAC/TCCATG 4 -- us2k10--------
    rs1874110151,2
    --61635434(+) ATCCAC/TGCTGC 4 -- us2k10--------
    rs1170300631,2
    C,F--61635485(+) ATATAC/TTCCAT 4 -- us2k11Minor allele frequency- T:0.01NA 120
    rs6086391,2
    C,H--61635543(-) ttaagC/Ttgggg 4 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs1124067251,2
    F--61635584(+) GGGAAT/CGAAGA 4 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1918069561,2
    --61635696(+) GCCTGA/GATACG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for SERPINB8 (61637159 - 61672278 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SERPINB8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv21739CNV Gain19812545
    nsv909693CNV Gain21882294
    nsv833673CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SERPINB8
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINB8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601697    OMIM disorders: --

    4 diseases for SERPINB8:    About MalaCards
    kimura disease    neuroendocrine tumor    myocardial infarction    psoriasis


    SERPINB8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SERPINB8
    Human Genome Epidemiology (HuGE) Navigator: SERPINB8 (4 documents)

    Export disorders for SERPINB8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERPINB8 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with SERPINB8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. (PubMed id 8530382)1, 2, 3, 9 Sprecher C.A.... Kisiel W. (J. Biol. Chem. 1995)
    2. Update of the human and mouse SERPIN gene superfamily. (PubMed id 24172014)1, 3 Heit C....Vasiliou V. (Hum. Genomics 2013)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Association analyses identify six new psoriasis susceptibility loci in the Chinese population. (PubMed id 20953187)1, 4 Sun L.D....Zhang X.J. (Nat. Genet. 2010)
    5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    6. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    7. Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3. (PubMed id 9268635)1, 3 Bartuski A.J....Silverman G.A. (Genomics 1997)
    8. Distribution of the human intracellular serpin protease inhibitor 8 in human tissues. (PubMed id 12417609)1, 9 Strik M.C....Kummer J.A. (J. Histochem. Cytochem. 2002)
    9. Inhibition of soluble recombinant furin by human proteinase inhibitor 8. (PubMed id 9442015)1, 9 Dahlen J.R....Kisiel W. (J. Biol. Chem. 1998)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5271 HGNC: 8952 AceView: SERPINB8 Ensembl:ENSG00000166401 euGenes: HUgn5271
    ECgene: SERPINB8 H-InvDB: SERPINB8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERPINB8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERPINB8 gene:
    Search GeneIP for patents involving SERPINB8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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