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SERPINB8 Gene

protein-coding   GIFtS: 59

GC18P059788
serpin peptidase inhibitor, clade B (ovalbumin), member 8
(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PI8)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CAP-2 3
CAP2 1, 2, 3, 5
OTTHUMP00000067001 2
PI8 2, 3, 5
Descriptions
Cytoplasmic antiproteinase 2 2, 3
Proteinase inhibitor 8 3
protease inhibitor 8 (ovalbumin type) 2
serine (or cysteine) proteinase inhibitor, clade B
(ovalbumin), member 8 1, 2
serpin peptidase inhibitor, clade B (ovalbumin), member 8 2
External Ids
HGNC: 89521
Entrez Gene: 52712
UniProtKB: P504523
Ensembl: ENSG000001664017
Search outside databases for aliases for SERPINB8 gene

Previous GC identifers: GC18P061476 GC18P061610 GC18P061422 GC18P059786 GC18P059295

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for SERPINB8
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SERPINB8 gene  

Entrez Gene cytogenetic band: 18q21.3   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.3

SERPINB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P059788:     (about GC identifiers)

Start:
59,788,238 bp from pter
End:
59,807,588 bp from pter
Size:
19,351 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000018.8  NT_025028.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SPB8_HUMAN, P50452 (See protein sequence)
Recommended Name: Serpin B8  
Size: 374 amino acids; 42767 Da
Subcellular location: Cytoplasm
Secondary accessions: Q7Z2V6

REFSEQ proteins (3 alternative transcripts): 
NP_001027018.1  NP_002631.3  NP_942130.1  


ENSEMBL proteins: 
ENSP00000331368 ENSP00000295211 ENSP00000381072 ENSP00000381075 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (SerpinB8)
Human Recombinant Proteins from Abnova (SERPINB8)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
GO:0005829 cytosol TAS8530382
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Antibodies for SERPINB8: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for SERPINB8
R&D Systems Antibodies for SERPINB8 (Serpin B8/Proteinase Inhibitor 8)
Antibodies from Abcam (SerpinB8), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (SERPINB8)
Novus Biologicals Antibody for SERPINB8

Assays for SERPINB8: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR000215 Protease_inhib_I4_serpin


   GeneDecks  SERPINB8 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P50452

ProtoNet protein and cluster: P50452

1 Blocks protein family: IPB000215 Serpin

UniProtKB/Swiss-Prot: SPB8_HUMAN, P50452
Similarity: Belongs to the serpin family. Ov-serpin subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (SERPINB8)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (SERPINB8)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002640

              Applied Biosystems Silencer® siRNAs for SERPINB8

              Sigma-Aldrich siRNA and siRNA Panels for SERPINB8  
                     Sigma-Aldrich shRNA for SERPINB8  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for SERPINB8
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001031848
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001031848
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001031848 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_002640

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity TAS8530382
GO:0005515 protein binding TAS8530382
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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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 Gene Network CentralTM Interacting Genes and Proteins Network for  SERPINB8 


1 Interacting protein for SERPINB8 (ENSP000002952113) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
--ensp: ENSP000003313683STRING (score=)
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SERPINB8

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (SERPINB8)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (SERPINB8)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002640

              Sigma-Aldrich siRNA and siRNA Panels for SERPINB8  
                     Sigma-Aldrich shRNA for SERPINB8  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001031848  NM_002640  NM_198833  

REFSEQ mRNAs for SERPINB8 gene (3 alternative transcripts): 

NM_001031848.1   NM_002640.3   NM_198833.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001031848  NM_002640  NM_198833  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001031848
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001031848
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001031848 

Additional cDNA sequence: 

AK300391.1 AK313782.1 BC034528.1 BX571754.1 DQ656055.2 L40377.1 U92984.1 

6 DOTS entries:

DT.209901  DT.95269447  DT.95269448  DT.92004519  DT.75174437  DT.303141 

24/66 AceView cDNA sequences (see all 66 ):

AL711105 CB122815 AA972628 BM696260 CF130399 BC034528 NM_198833 CK904587 
AA360401 NM_002640 CK904586 W61361 CB962380 AI925897 U92984 BQ435307 
CD369662 BM987817 AI095851 L40377 BQ003005 AF118928 BX571754 BQ929418 

highest scoring ESTs for SERPINB8:

AL121194 L40377 AA360401 AA373798 AA853496 AF118928 AI074846 AI675932 AI767324 AI925897 

Unigene Cluster for SERPINB8:

Serpin peptidase inhibitor, clade B (ovalbumin), member 8
Hs.368077  [show with all ESTs]
Unigene Representative Sequence: NM_198833


GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:
ENST00000353706  ENST00000295211  ENST00000397985  ENST00000397988  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SERPINB8 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for SERPINB8

1 / 2 / 3

5 probe-sets matching SERPINB8 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

36312_at2, 3 U95-A 1 1.00 1.00 0.90 0.79 L40377 1.00 0.90 0.95 1
81485_at2, 3 U95-E 1 1.00 1.00 0.93 1.23 AL121194 1.00 0.90 0.95 1

206034_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002640 0.60 0.83 0.73 1

206034_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1554616_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  SERPINB8 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
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Data from (Publications) and GNF BioGPS
    About these images
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CGAP SAGE TAG: ATTTGTTGAT

SOURCE GeneReport for Unigene cluster: Hs.368077

Expression variation in blood from EXPOLDB for SERPINB8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for SERPINB8 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
SERPINB81   -- serpin peptidase inhibitor, clade B (ovalbumin), member more 84.31(n)
83.16(a)
607205  XM_851819.1  XP_856912.1 
chimpanzee
(Pan troglodytes)
SERPINB81   -- serpin peptidase inhibitor, clade B (ovalbumin), member more 99.38(n)
99.2(a)
455461  XM_512167.2  XP_512167.2 
cow
(Bos taurus)
SERPINB81   -- serpin peptidase inhibitor, clade B (ovalbumin), member more 85.29(n)
82.89(a)
513825  NM_001035287.1  NP_001030364.1 
rat
(Rattus norvegicus)
Serpinb81   -- serine (or cysteine) peptdiase inhibitor, clade B, more 81.02(n)
77.01(a)
288937  XM_222490.4  XP_222490.4 
mouse
(Mus musculus)
Serpinb81, 5 15
serine (or cysteine) peptidase inhibitor, clade B, more5
serine (or cysteine) peptdiase inhibitor, clade B, more1
81.11(n)1
78.34(a)1
207251  NM_011459.31  NP_035589.11 
 AK0326595  AK0368115  (see all 10)
About this table        Species with no ortholog for SERPINB8

ENSEMBL Gene Tree for SERPINB8
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for SERPINB8 gene
SERPINB72  SERPINB92  SERPINB62  SERPINB132  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/149 NCBI SNPs in SERPINB8 are shown (see all 149 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 104)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 18 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs19442701,2
A,C,F,H,O59798049(-) AACCTC/TGGTGA 3 R/Q mis1 ese315Minor allele frequency- N:0.00NA EA EU WA 2106
rs31699831,2
C,F,H,O59805277(+) TGTCAA/GCTGAG 3 T/A mis1 ng31 ese317Minor allele frequency- G:0.19MN NA EU EA WA 1658
rs38266161,2
A,C,F,H59805443(+) CAGGCA/GCCACA 2 H/R mis1 ese314Minor allele frequency- N:0.00EA NA EU WA 2618
--
rs65674071,2
A,C,F,H59788205(+) TGCCCA/GCAGAC 3 -- ng514Minor allele frequency- G:0.34EU EA WA 412
rs37449581,2
A,C,F,H59805309(+) GTTGCC/TCACAA 3 A/A syn1 ng31 ese39Minor allele frequency- T:0.07EA NA EU WA 2104
rs99615321,2
A,C,F,H59806180(+) CTTACG/ACAACA 2 -- ut3112Minor allele frequency- A:0.19EU EA WA NA 1188
rs16484931,2
C,F,H59801842(-) ACCAGC/GTTTGT 3 K/N mis1 ese312Minor allele frequency- G:0.05EA NA MN EU WA 1036
rs5977751,2
C,F,H59806646(-) CAGCAT/CAATAT 2 -- ut313Minor allele frequency- C:0.31EA WA 260
rs5143151,2
C,F,H59807765(+) ttctcT/Ccttct 2 -- ng318Minor allele frequency- C:0.41EU EA WA 784
rs72273661,2
C,F,H59804737(+) CACTCA/GCAGTA 3 -- int1 ut317Minor allele frequency- G:0.01EU EA WA NA 560
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HapMap Linkage Disequilibrium images for SERPINB8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601697

1 PharmGKB disease relationship for SERPINB8 gene
Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
About this table

Human Genome Epidemiology Navigator: SERPINB8 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/21 PubMed articles for SERPINB8 gene (see all 21 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5271 HGNC: 8952 AceView: SERPINB8 Ensembl:ENSG00000166401 euGenes: HUgn5271
ECgene: SERPINB8 H-InvDB: SERPINB8
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for SERPINB8:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SERPINB8-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for SERPINB8 Antibodies for SERPINB8
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for SERPINB8 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search OriGene for SERPINB8
 Search Tocris compounds for SERPINB8




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for SERPINB8

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