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Aliases for SERPINB8 Gene

Aliases for SERPINB8 Gene

  • Serpin Family B Member 8 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 8 2 3 5
  • Cytoplasmic Antiproteinase 2 2 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 8 2 3
  • Peptidase Inhibitor 8 3 4
  • CAP2 3 4
  • PI-8 3 4
  • PI8 3 4
  • Protease Inhibitor 8 (Ovalbumin Type) 3
  • CAP-2 4

External Ids for SERPINB8 Gene

Previous HGNC Symbols for SERPINB8 Gene

  • PI8

Previous GeneCards Identifiers for SERPINB8 Gene

  • GC18P061476
  • GC18P061610
  • GC18P061422
  • GC18P059786
  • GC18P059295
  • GC18P059788
  • GC18P061637
  • GC18P058338

Summaries for SERPINB8 Gene

Entrez Gene Summary for SERPINB8 Gene

  • The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]

GeneCards Summary for SERPINB8 Gene

SERPINB8 (Serpin Family B Member 8) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

Gene Wiki entry for SERPINB8 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB8 Gene

Genomics for SERPINB8 Gene

Regulatory Elements for SERPINB8 Gene

Enhancers for SERPINB8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SERPINB8 on UCSC Golden Path with GeneCards custom track

Promoters for SERPINB8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SERPINB8 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERPINB8 Gene

63,969,925 bp from pter
64,006,821 bp from pter
36,897 bases
Plus strand

Genomic View for SERPINB8 Gene

Genes around SERPINB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB8 Gene

Proteins for SERPINB8 Gene

  • Protein details for SERPINB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serpin B8
    Protein Accession:
    Secondary Accessions:
    • B4DTW2
    • Q7Z2V6
    • Q8N178

    Protein attributes for SERPINB8 Gene

    374 amino acids
    Molecular mass:
    42767 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB8 Gene


neXtProt entry for SERPINB8 Gene

Proteomics data for SERPINB8 Gene at MOPED

Post-translational modifications for SERPINB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for SERPINB8 (Serpin B8/Proteinase Inhibitor 8)

No data available for DME Specific Peptides for SERPINB8 Gene

Domains & Families for SERPINB8 Gene

Gene Families for SERPINB8 Gene

Protein Domains for SERPINB8 Gene


Suggested Antigen Peptide Sequences for SERPINB8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serpin family. Ov-serpin subfamily.
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB8: view

Function for SERPINB8 Gene

genes like me logo Genes that share phenotypes with SERPINB8: view

Animal Model Products

CRISPR Products

miRNA for SERPINB8 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERPINB8 Gene

Localization for SERPINB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB8 Gene


Subcellular locations from

Jensen Localization Image for SERPINB8 Gene COMPARTMENTS Subcellular localization image for SERPINB8 gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 2
nucleus 2
plasma membrane 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SERPINB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 8530382
genes like me logo Genes that share ontologies with SERPINB8: view

Pathways & Interactions for SERPINB8 Gene

genes like me logo Genes that share pathways with SERPINB8: view

Pathways by source for SERPINB8 Gene

2 Reactome pathways for SERPINB8 Gene
1 GeneGo (Thomson Reuters) pathway for SERPINB8 Gene

Gene Ontology (GO) - Biological Process for SERPINB8 Gene


No data available for SIGNOR curated interactions for SERPINB8 Gene

Drugs & Compounds for SERPINB8 Gene

No Compound Related Data Available

Transcripts for SERPINB8 Gene

Unigene Clusters for SERPINB8 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB8 Gene

No ASD Table

Relevant External Links for SERPINB8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERPINB8 Gene

mRNA expression in normal human tissues for SERPINB8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB8 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x4.8).

Protein differential expression in normal tissues from HIPED for SERPINB8 Gene

This gene is overexpressed in Monocytes (18.1), Peripheral blood mononuclear cells (15.9), and Platelet (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERPINB8 Gene

SOURCE GeneReport for Unigene cluster for SERPINB8 Gene Hs.368077

genes like me logo Genes that share expression patterns with SERPINB8: view

Protein tissue co-expression partners for SERPINB8 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SERPINB8 Gene

Orthologs for SERPINB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SERPINB8 35
  • 85.29 (n)
  • 82.89 (a)
  • 83 (a)
(Canis familiaris)
Mammalia SERPINB8 35
  • 84.58 (n)
  • 83.42 (a)
  • 83 (a)
(Mus musculus)
Mammalia Serpinb8 35
  • 81.11 (n)
  • 78.34 (a)
Serpinb8 16
Serpinb8 36
  • 78 (a)
(Pan troglodytes)
Mammalia SERPINB8 35
  • 99.38 (n)
  • 99.2 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Serpinb8 35
  • 81.11 (n)
  • 77.27 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6687 37
  • 31 (a)
CG6717 37
  • 29 (a)
CG7722 37
  • 28 (a)
CG9455 37
  • 34 (a)
CG9460 37
  • 31 (a)
Spn1 37
  • 34 (a)
Spn2 37
  • 34 (a)
Spn3 37
  • 35 (a)
Spn43Aa 37
  • 33 (a)
Spn5 37
  • 30 (a)
Spn6 37
  • 33 (a)
Species with no ortholog for SERPINB8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINB8 Gene

Gene Tree for SERPINB8 (if available)
Gene Tree for SERPINB8 (if available)

Paralogs for SERPINB8 Gene Pseudogenes for SERPINB8 Gene

genes like me logo Genes that share paralogs with SERPINB8: view

Variants for SERPINB8 Gene

Sequence variations from dbSNP and Humsavar for SERPINB8 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1944270 - 63,979,835(-) AACCT(C/T)GGTGA reference, missense, utr-variant-5-prime
rs1648493 - 63,983,628(-) ACCAG(C/G)TTTGT reference, missense, utr-variant-5-prime
rs3169983 - 63,987,063(+) TGTCA(A/G)CTGAG intron-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs3826616 - 63,987,229(+) CAGGC(A/G)CCACA intron-variant, reference, missense, utr-variant-3-prime
rs213065 -- 64,004,712(-) TGTGG(A/C)ACCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINB8 Gene

Variant ID Type Subtype PubMed ID
esv21739 CNV Gain 19812545
nsv909693 CNV Gain 21882294
nsv833673 CNV Gain 17160897

Variation tolerance for SERPINB8 Gene

Residual Variation Intolerance Score: 65.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.37; 81.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SERPINB8 Gene

Disorders for SERPINB8 Gene

Relevant External Links for SERPINB8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SERPINB8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINB8 Gene

Publications for SERPINB8 Gene

  1. Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. (PMID: 8530382) Sprecher C.A. … Kisiel W. (J. Biol. Chem. 1995) 2 3 4 23 67
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  3. Distribution of the human intracellular serpin protease inhibitor 8 in human tissues. (PMID: 12417609) Strik M.C. … Kummer J.A. (J. Histochem. Cytochem. 2002) 3 23
  4. Inhibition of soluble recombinant furin by human proteinase inhibitor 8. (PMID: 9442015) Dahlen J.R. … Kisiel W. (J. Biol. Chem. 1998) 3 23
  5. Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3. (PMID: 9268635) Bartuski A.J. … Silverman G.A. (Genomics 1997) 2 3

Products for SERPINB8 Gene

Sources for SERPINB8 Gene