SERPINB8 Gene
protein-coding GIFtS : 59
GC18P059788
serpin peptidase inhibitor, clade B (ovalbumin), member 8 (Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8 )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: PI8 )
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Aliases & Descriptions for SERPINB8
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CAP-2 3 CAP2 1 , 2 , 3 , 5 OTTHUMP00000067001 2 PI8 2 , 3 , 5
Descriptions Cytoplasmic antiproteinase 2 2 , 3 Proteinase inhibitor 8 3 protease inhibitor 8 (ovalbumin type) 2 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8 1 , 2 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2
Search outside databases for aliases for SERPINB8 genePrevious GC identifers: GC18P061476 GC18P061610 GC18P061422 GC18P059786 GC18P059295
Summaries for SERPINB8 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Gene Wiki entry for SERPINB8
Genomic Location for SERPINB8
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the SERPINB8 gene Entrez Gene cytogenetic band: 18q21.3 Ensembl cytogenetic band: 18q21.33 HGNC cytogenetic band: 18q21.3 SERPINB8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure
GeneLoc location for GC18P059788:
(about GC identifiers )
Start:
59,788,238 bp from pter
End:
59,807,588 bp from pter
Size:
19,351 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000018.8 NT_025028.13 Proteins for SERPINB8
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: SPB8_HUMAN, P50452 (See
protein sequence )Recommended Name: Serpin B8 Size : 374 amino acids; 42767 Da
Subcellular location : Cytoplasm
Secondary accessions : Q7Z2V6
REFSEQ proteins (3 alternative transcripts):
NP_001027018.1 NP_002631.3 NP_942130.1 ENSEMBL proteins: ENSP00000331368 ENSP00000295211 ENSP00000381072 ENSP00000381075 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for SERPINB8: Assays for SERPINB8:
Protein
Domains/ Families for SERPINB8(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P50452 ProtoNet protein and cluster: P50452
1 Blocks protein family : IPB000215 Serpin UniProtKB/Swiss-Prot: SPB8_HUMAN, P50452 Similarity : Belongs to the serpin family. Ov-serpin subfamily
Gene Function for SERPINB8
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_002640 Applied Biosystems Silencer ® siRNAs for SERPINB8 Sigma-Aldrich siRNA and siRNA Panels for SERPINB8 Sigma-Aldrich shRNA for SERPINB8 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001031848                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001031848                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001031848  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002640 2 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for SERPINB8
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for SERPINB8 1 Interacting protein for SERPINB8 (ENSP00000295211 3 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for SERPINB8 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for SERPINB8
Transcripts for SERPINB8(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_002640 Sigma-Aldrich siRNA and siRNA Panels for SERPINB8 Sigma-Aldrich shRNA for SERPINB8 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001031848 NM_002640 NM_198833
REFSEQ mRNAs for SERPINB8 gene (3 alternative transcripts): NM_001031848.1 NM_002640.3 NM_198833.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001031848 NM_002640 NM_198833
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001031848                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001031848                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001031848  
Additional cDNA sequence: AK300391.1 AK313782.1 BC034528.1 BX571754.1 DQ656055.2 L40377.1 U92984.1
6 DOTS entries : DT.209901 DT.95269447 DT.95269448 DT.92004519 DT.75174437 DT.303141
24/66 AceView cDNA sequences (see all 66
):AL711105 CB122815 AA972628 BM696260 CF130399 BC034528 NM_198833 CK904587 AA360401 NM_002640 CK904586 W61361 CB962380 AI925897 U92984 BQ435307 CD369662 BM987817 AI095851 L40377 BQ003005 AF118928 BX571754 BQ929418
highest scoring ESTs for SERPINB8 :AL121194 L40377 AA360401 AA373798 AA853496 AF118928 AI074846 AI675932 AI767324 AI925897
Unigene Cluster for SERPINB8: Serpin peptidase inhibitor, clade B (ovalbumin), member 8 Hs.368077 [show with all ESTs ] Unigene Representative Sequence: NM_198833 GeneLoc Exon Structure 4 Ensembl transcripts including schematic representations : ENST00000353706
ENST00000295211
ENST00000397985
ENST00000397988
Expression for SERPINB8
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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SERPINB8 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for SERPINB8 1 / 2 / 3
5 probe-sets matching SERPINB8 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: ATTTGTTGATSOURCE GeneReport for Unigene cluster: Hs.368077 Expression variation in blood from EXPOLDB for SERPINB8
Orthologs for SERPINB8
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for SERPINB8 gene from 5/7 species (see all 7
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
SERPINB81
--
serpin peptidase inhibitor, clade B (ovalbumin), member more
84.31(n) 83.16(a)
607205 XM_851819.1 XP_856912.1
chimpanzee (Pan troglodytes)
SERPINB81
--
serpin peptidase inhibitor, clade B (ovalbumin), member more
99.38(n) 99.2(a)
455461 XM_512167.2 XP_512167.2
cow (Bos taurus)
SERPINB81
--
serpin peptidase inhibitor, clade B (ovalbumin), member more
85.29(n) 82.89(a)
513825 NM_001035287.1 NP_001030364.1
rat (Rattus norvegicus)
Serpinb81
--
serine (or cysteine) peptdiase inhibitor, clade B, more
81.02(n) 77.01(a)
288937 XM_222490.4 XP_222490.4
mouse (Mus musculus)
Serpinb81 , 5
15
serine (or cysteine) peptidase inhibitor, clade B, more 5 serine (or cysteine) peptdiase inhibitor, clade B, more 1
81.11(n) 1 78.34(a) 1
20725 1 NM_011459.3 1 NP_035589.1 1 AK032659 5 AK036811 5 (see all 10 )
About this table Species with no ortholog for SERPINB8 ENSEMBL Gene Tree for SERPINB8 Paralogs for SERPINB8 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for SERPINB8 gene SERPINB7 2 SERPINB9 2 SERPINB6 2 SERPINB13 2
SNPs/Variants for SERPINB8 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for SERPINB8 (up to first 250kb)
Disorders & Mutations for SERPINB8
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 601697 1 PharmGKB disease relationship for SERPINB8 gene About this table Human Genome Epidemiology Navigator: SERPINB8 (2 documents)
Medical News for SERPINB8 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for SERPINB8 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/21 PubMed articles for SERPINB8 gene (see all 21
):
Search for SERPINB8
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SERPINB8
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing SERPINB8
(According to HUGE )
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--
Specialized Databases showing SERPINB8 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for SERPINB8 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for SERPINB8:
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