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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINB8 Gene

protein-coding   GIFtS: 60
GCID: GC18P061637

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: PI8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 81 2     Peptidase Inhibitor 82 3
PI81 2 3 5     PI-82 3
Cytoplasmic Antiproteinase 21 2 3     Protease Inhibitor 8 (Ovalbumin Type)2
CAP22 3 5     Serpin B82
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 81 2     CAP-23

External Ids:    HGNC: 89521   Entrez Gene: 52712   Ensembl: ENSG000001664017   OMIM: 6016975   UniProtKB: P504523   

Export aliases for SERPINB8 gene to outside databases

Previous GC identifers: GC18P061476 GC18P061610 GC18P061422 GC18P059786 GC18P059295 GC18P059788 GC18P058338


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SERPINB8 Gene:
The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of
intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular
differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a
tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 (PubMed
2690952)). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease
inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1
(MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal
extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate
position (summary by Bartuski et al., 1997 (PubMed 9268635)).(supplied by OMIM, Jan 2010)

GeneCards Summary for SERPINB8 Gene: 
SERPINB8 (serpin peptidase inhibitor, clade B (ovalbumin), member 8) is a protein-coding gene. Diseases associated with SERPINB8 include kimura disease, and neuroendocrine tumor, and among its related super-pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and protein binding. An important paralog of this gene is SERPINB7.

Gene Wiki entry for SERPINB8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_025028.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINB8 gene promoter:
         RP58   POU3F1   NF-E2 p45   Tal-1beta   YY1   E47   MEF-2A   aMEF-2   Msx-1   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINB8 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINB8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.1   Ensembl cytogenetic band:  18q22.1   HGNC cytogenetic band: 18q22.1

SERPINB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB8 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P061637:  view genomic region     (about GC identifiers)

Start:
61,637,159 bp from pter      End:
61,672,278 bp from pter
Size:
35,120 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPB8_HUMAN, P50452 (See protein sequence)
Recommended Name: Serpin B8  
Size: 374 amino acids; 42767 Da
Subcellular location: Cytoplasm
Secondary accessions: Q7Z2V6 Q8N178
Alternative splicing: 2 isoforms:  P50452-1   P50452-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SERPINB8: NX_P50452

Explore proteomics data for SERPINB8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50452

  • SERPINB8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERPINB8 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001027018.1  NP_001263419.1  NP_002631.3  NP_942130.1  

    ENSEMBL proteins: 
     ENSP00000381072   ENSP00000381075   ENSP00000414580   ENSP00000393456   ENSP00000295211  
     ENSP00000331368   ENSP00000438328  
    Reactome Protein details: P50452
    Human Recombinant Protein Products for SERPINB8: 
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    Novus Biologicals SERPINB8 Protein
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    Sino Biological Recombinant Protein for SERPINB8
    Sino Biological Cell Lysate for SERPINB8 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005829cytosol IDA8530382

    SERPINB8 for ontologies           About GeneDecksing



    SERPINB8 Antibody Products: 
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    Assay Products for SERPINB8: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P50452

    ProtoNet protein and cluster: P50452

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: SPB8_HUMAN, P50452
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    SERPINB8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IDA8530382
    GO:0005515protein binding IPI8530382
         
    SERPINB8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SERPINB8:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SERPINB8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERPINB8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINB8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERPINB8 

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINB8:
    hsa-miR-607 hsa-miR-3688-3p hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidSERPINB8 3' UTR sequence
    Inhib. RNA
    Products:
        
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                         Customized lentivirus expression plasmids for stable overexpression of SERPINB8 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SERPINB8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Platelet activation, signaling and aggregation
    Hemostasis0.43
    2Dissolution of Fibrin Clot
    Dissolution of Fibrin Clot
    3CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
    CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for SERPINB8
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)


    2        Reactome Pathways for SERPINB8
        Hemostasis
    Dissolution of Fibrin Clot



    SERPINB8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINB8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for SERPINB8 (P504523 ENSP000003313684) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FURINP099583, ENSP000002681714I2D: score=3 STRING: ENSP00000268171
    BCL2P104153, ENSP000003296234I2D: score=1 STRING: ENSP00000329623
    F2P007343, ENSP000003085414I2D: score=1 STRING: ENSP00000308541
    F10P007423, ENSP000003647094I2D: score=2 STRING: ENSP00000364709
    PRSS1P074773, ENSP000003087204I2D: score=2 STRING: ENSP00000308720
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity IDA8530382
    GO:0030162regulation of proteolysis IBA--

    SERPINB8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINB8 (SPB8)

    Search CenterWatch for drugs/clinical trials and news about SERPINB8 / SPB8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERPINB8 gene (4 alternative transcripts): 
    NM_001031848.1  NM_001276490.1  NM_002640.3  NM_198833.1  

    Unigene Cluster for SERPINB8:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 8
    Hs.368077  [show with all ESTs]
    Unigene Representative Sequence: NM_198833
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397985(uc002lju.3 uc010xex.2) ENST00000397988(uc002ljt.3)
    ENST00000448851 ENST00000441827(uc002ljs.1) ENST00000295211 ENST00000493661
    ENST00000353706(uc002ljv.3) ENST00000542677
    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINB8:
    hsa-miR-607 hsa-miR-3688-3p hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidSERPINB8 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB8
    Sirion Biotech Customized lentivirus for stable overexpression of SERPINB8 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB8

    Additional mRNA sequence: 

    AK300391.1 AK313782.1 BC034528.1 BX571754.1 DQ656055.2 L40377.1 U92984.1 

    5 DOTS entries:

    DT.209901  DT.95269447  DT.95269448  DT.92004519  DT.303141 

    24/66 AceView cDNA sequences (see all 66):

    AL711105 BM696260 CK904587 AA360401 AA972628 NM_002640 CK904586 CB122815 
    CF130399 BC034528 NM_198833 AL708543 CB151896 BQ003005 AW205887 BQ929418 
    BG742444 BX098348 CB962380 W61361 AI767324 AL121194 BQ435307 BM987817 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINB8 expression in normal human tissues (normalized intensities)      SERPINB8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTGTTGAT
    SERPINB8 Expression
    About this image


    SERPINB8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             bone marrow-derived macrophages   
     
     Uterus (Reproductive System)
             endometrial endothelial cell   
     
     Chorion (Extraembryonic Tissues)
             chorion villus cells   
     
     Fibroblast (Uncategorized)
             Human Ovarian Fibroblasts (HOF)   
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...

    See SERPINB8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINB8

    SOURCE GeneReport for Unigene cluster: Hs.368077
        SABiosciences Custom PCR Arrays for SERPINB8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINB8 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpinb81 , 5 serine (or cysteine) peptidase inhibitor, clade B, more1, 5 81.11(n)1
    78.34(a)1
      1 (50.34 cM)5
    207251  NM_011459.41  NP_035589.11 
     1075900065 
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054232.12   -- 73.33(n)    BC054232.1 


    ENSEMBL Gene Tree for SERPINB8 (if available)
    TreeFam Gene Tree for SERPINB8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINB8 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB32  SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINB112  
    SERPINE32  SERPINB132  
    18/37 SIMAP similar genes for SERPINB8 using alignment to 5 protein entries:     SPB8_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O07189    SERPINB9    SERPINB6    PLANH2    HMSD    SCCA1
    SERPINB1    SERPINB10    SERPINB3    SERPINB12    SERPINB11    DKFZp686D06190
    SERPINB4    SCCA2    SERPINB5    SERPINC1    SERPINA1    AT3

    SERPINB8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SERPINB8
    PGOHUM00000243470


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/543 SNPs in SERPINB8 are shown (see all 543)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs744724451,2
    C,F--61635298(+) CTTTGA/TTTCTT 4 -- us2k12Minor allele frequency- T:0.06NA EA 122
    rs6095441,2
    H--61635314(-) AGGAAG/CAGGGA 4 -- us2k1 trp34Minor allele frequency- C:0.00NS EA 402
    rs1818598981,2
    --61635352(+) TTATGC/TCCTGG 4 -- us2k10--------
    rs617445681,2
    C,F--61635387(+) TCTCCA/TTTTCT 4 -- us2k13Minor allele frequency- T:0.27NS WA NA 316
    rs1496496761,2
    --61635430(+) TCTCAC/TCCATG 4 -- us2k10--------
    rs1874110151,2
    --61635434(+) ATCCAC/TGCTGC 4 -- us2k10--------
    rs1170300631,2
    C,F--61635485(+) ATATAC/TTCCAT 4 -- us2k11Minor allele frequency- T:0.01NA 120
    rs6086391,2
    C,H--61635543(-) ttaagC/Ttgggg 4 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs1124067251,2
    F--61635584(+) GGGAAT/CGAAGA 4 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1918069561,2
    --61635696(+) GCCTGA/GATACG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for SERPINB8 (61637159 - 61672278 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SERPINB8:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv21739CNV Gain19812545
    nsv909693CNV Gain21882294
    nsv833673CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601697    OMIM disorders: --

    3 diseases for SERPINB8:    About MalaCards
    kimura disease    neuroendocrine tumor    myocardial infarction


    SERPINB8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SERPINB8
    Human Genome Epidemiology (HuGE) Navigator: SERPINB8 (4 documents)

    Export disorders for SERPINB8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINB8 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with SERPINB8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. (PubMed id 8530382)1, 2, 3, 9 Sprecher C.A.... Kisiel W. (1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Association analyses identify six new psoriasis susce ptibility loci in the Chinese population. (PubMed id 20953187)1, 4 Sun L.D....Zhang X.J. (2010)
    4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
    5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (2008)
    6. Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3. (PubMed id 9268635)1, 3 Bartuski A.J....Silverman G.A. (1997)
    7. Distribution of the human intracellular serpin protease inhibitor 8 in human tissues. (PubMed id 12417609)1, 9 Strik M.C....Kummer J.A. (2002)
    8. Inhibition of soluble recombinant furin by human proteinase inhibitor 8. (PubMed id 9442015)1, 9 Dahlen J.R....Kisiel W. (1998)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (PubMed id 22837378)1 Wilk J.B....Stricker B.H. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5271 HGNC: 8952 AceView: SERPINB8 Ensembl:ENSG00000166401 euGenes: HUgn5271
    ECgene: SERPINB8 H-InvDB: SERPINB8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINB8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERPINB8 gene:
    Search GeneIP for patents involving SERPINB8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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