Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERPINB7 Gene

Aliases for SERPINB7 Gene

  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 7 2 3
  • MEGSIN 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 7 2 3
  • Tp55 3 4
  • PPKN 3 6
  • Mesangium Predominant Gene, Megsin 3
  • Serpin B7 3

External Ids for SERPINB7 Gene

Previous GeneCards Identifiers for SERPINB7 Gene

  • GC18P061281
  • GC18P061394
  • GC18P059569
  • GC18P059571
  • GC18P058121

Summaries for SERPINB7 Gene

Entrez Gene Summary for SERPINB7 Gene

  • This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for SERPINB7 Gene

SERPINB7 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 7) is a Protein Coding gene. Diseases associated with SERPINB7 include palmoplantar keratoderma, nagashima type and iga glomerulonephritis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB7 Gene

  • Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin

Gene Wiki entry for SERPINB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB7 Gene

Genomics for SERPINB7 Gene

Regulatory Elements for SERPINB7 Gene

Transcription factor binding sites by QIAGEN in the SERPINB7 gene promoter:

Genomic Location for SERPINB7 Gene

63,752,935 bp from pter
63,805,376 bp from pter
52,442 bases
Plus strand

Genomic View for SERPINB7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB7 Gene

Proteins for SERPINB7 Gene

  • Protein details for SERPINB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serpin B7
    Protein Accession:
    Secondary Accessions:
    • B4DUW8
    • F5GZC0
    • Q1ED45
    • Q3KPG4

    Protein attributes for SERPINB7 Gene

    380 amino acids
    Molecular mass:
    42905 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB7 Gene


neXtProt entry for SERPINB7 Gene

Proteomics data for SERPINB7 Gene at MOPED

Post-translational modifications for SERPINB7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SERPINB7 Gene

Domains for SERPINB7 Gene

Gene Families for SERPINB7 Gene

  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINB7 Gene

Suggested Antigen Peptide Sequences for SERPINB7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O75635
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB7: view

Function for SERPINB7 Gene

Molecular function for SERPINB7 Gene

UniProtKB/Swiss-Prot Function: Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin

Gene Ontology (GO) - Molecular Function for SERPINB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINB7 Gene

Localization for SERPINB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB7 Gene


Subcellular locations from

Jensen Localization Image for SERPINB7 Gene COMPARTMENTS Subcellular localization image for SERPINB7 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SERPINB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SERPINB7: view

Pathways for SERPINB7 Gene

SuperPathways for SERPINB7 Gene

No Data Available

Interacting Proteins for SERPINB7 Gene

Gene Ontology (GO) - Biological Process for SERPINB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IBA --
GO:0030162 regulation of proteolysis --
GO:0032914 positive regulation of transforming growth factor beta1 production IEA --
GO:0032967 positive regulation of collagen biosynthetic process IEA --
GO:0072126 positive regulation of glomerular mesangial cell proliferation IEA --
genes like me logo Genes that share ontologies with SERPINB7: view

No data available for Pathways by source for SERPINB7 Gene

Compounds for SERPINB7 Gene

(1) Novoseek inferred chemical compound relationships for SERPINB7 Gene

Compound -log(P) Hits PubMed IDs
serine 58.4 14
genes like me logo Genes that share compounds with SERPINB7: view

Transcripts for SERPINB7 Gene

Unigene Clusters for SERPINB7 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINB7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SERPINB7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB7 Gene

No ASD Table

Relevant External Links for SERPINB7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERPINB7 Gene

mRNA expression in normal human tissues for SERPINB7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB7 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (26.2) and Skin - Not Sun Exposed (Suprapubic) (20.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERPINB7 Gene

SOURCE GeneReport for Unigene cluster for SERPINB7 Gene Hs.138202

mRNA Expression by UniProt/SwissProt for SERPINB7 Gene

Tissue specificity: Predominantly expressed in mesangial cells. Expressed in the epidermis of the whole body.
genes like me logo Genes that share expressions with SERPINB7: view

In Situ Assay Products

Orthologs for SERPINB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERPINB7 35
  • 99.47 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia SERPINB7 35
  • 83.77 (n)
  • 79.74 (a)
  • 80 (a)
(Canis familiaris)
Mammalia SERPINB7 35
  • 85.44 (n)
  • 82.63 (a)
  • 83 (a)
(Mus musculus)
Mammalia Serpinb7 35
  • 80.18 (n)
  • 73.95 (a)
Serpinb7 16
Serpinb7 36
  • 74 (a)
(Monodelphis domestica)
Mammalia SERPINB7 36
  • 65 (a)
(Rattus norvegicus)
Mammalia Serpinb7 35
  • 78.77 (n)
  • 73.68 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
fruit fly
(Drosophila melanogaster)
Insecta nec 36
  • 21 (a)
Spn1 36
  • 28 (a)
Spn2 36
  • 26 (a)
Spn28Da 36
  • 24 (a)
Spn28Db 36
  • 23 (a)
Spn3 36
  • 26 (a)
Spn4 36
  • 25 (a)
Spn42Db 36
  • 25 (a)
Spn42Dc 36
  • 27 (a)
Spn42De 36
  • 28 (a)
Spn43Aa 36
  • 25 (a)
Spn43Ab 36
  • 22 (a)
Spn47C 36
  • 25 (a)
Spn6 36
  • 28 (a)
Spn7 36
  • 25 (a)
Spn5 37
  • 28 (a)
(Caenorhabditis elegans)
Secernentea srp-7 37
  • 30 (a)
srp-6 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for SERPINB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINB7 Gene

Gene Tree for SERPINB7 (if available)
Gene Tree for SERPINB7 (if available)

Paralogs for SERPINB7 Gene

genes like me logo Genes that share paralogs with SERPINB7: view

Variants for SERPINB7 Gene

Sequence variations from dbSNP and Humsavar for SERPINB7 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs906118 -- 63,755,880(-) GTCTC(A/G)CTTTG intron-variant
rs970677 -- 63,779,674(-) GCTTA(A/G)GTAAG intron-variant
rs1055900 -- 63,805,179(+) GGACC(A/T)ACCAA utr-variant-3-prime
rs1055901 -- 63,805,221(+) TTTGG(C/T)CTTTC utr-variant-3-prime
rs1055902 -- 63,805,309(+) CATAT(C/T)TCATA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SERPINB7 Gene

Variant ID Type Subtype PubMed ID
nsv833672 CNV Gain 17160897
esv21739 CNV Gain 19812545
esv1109412 CNV Insertion 17803354

Relevant External Links for SERPINB7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB7 Gene

Disorders for SERPINB7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for SERPINB7 Gene including...

Search for SERPINB7 Gene in MalaCards »

(1) OMIM Diseases for SERPINB7 Gene (603357)


  • Keratoderma, palmoplantar, Nagashima type (PPKN) [MIM:615598]: An autosomal recessive, non-syndromic, diffuse palmoplantar keratosis characterized by well-demarcated diffuse erythematous hyperkeratosis expanding onto the dorsal surfaces of the palms and feet and the Achilles tendon area. Hyperkeratosis is mild and non-progressive. {ECO:0000269 PubMed:24207119}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for SERPINB7 Gene

(10) Novoseek inferred disease relationships for SERPINB7 Gene

Disease -log(P) Hits PubMed IDs
nephropathy iga 80.5 14
diabetic nephropathies 61.6 9
nephrotic syndrome minimal change 60.5 2
proteinuria 52.7 1
nephritis 50.2 2

Relevant External Links for SERPINB7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SERPINB7: view

Publications for SERPINB7 Gene

  1. A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy. (PMID: 9710452) Miyata T. … Kurokawa K. (J. Clin. Invest. 1998) 3 4 23
  2. Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy. (PMID: 16431886) Xia Y. … Wang Y. (Nephrol. Dial. Transplant. 2006) 3 23 48
  3. [Association of single nucleotide polymorphism of megsin gene with IgA nephropathy]. (PMID: 16796905) Wang Z.H. … Han B. (Zhonghua Yi Xue Za Zhi 2006) 3 23 48
  4. [Correlation between traditional Chinese medicine syndromes in primary immunoglobulin A nephropathy and A267G in 5'-untranslated region within exonal of megsin gene]. (PMID: 18471408) Zhong Y.F. … Wang Z.H. (Zhong Xi Yi Jie He Xue Bao 2008) 3 23 48
  5. The influence of two megsin polymorphisms on the progression of IgA nephropathy. (PMID: 18498720) MaixnerovA! D. … Tesar V. (Folia Biol. (Praha) 2008) 3 23 48

Products for SERPINB7 Gene

Sources for SERPINB7 Gene

Back to Top