Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINB7 Gene

protein-coding   GIFtS: 50
GCID: GC18P061394

serpin peptidase inhibitor, clade B (ovalbumin), member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
 Explore 9 diseases affiliated with
SERPINB7 via our new
 Human Malady Compendium 
Biological research products
for SERPINB7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 71 2     Mesangium Predominant Gene, Megsin2
MEGSIN1 2 5     Serpin B72
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 71 2     Megsin3
TP552 3     

External Ids:    HGNC: 139021   Entrez Gene: 87102   Ensembl: ENSG000001663967   OMIM: 6033575   UniProtKB: O756353   

Export aliases for SERPINB7 gene to outside databases

Previous GC identifers: GC18P061281 GC18P059569 GC18P059571 GC18P058121


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SPB7_HUMAN, O75635
Function: Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes
via its action as a serpin

Gene Wiki entry for SERPINB7


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINB7 gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINB7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINB7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.33   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.33

SERPINB7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB7 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P061394:  view genomic region     (about GC identifiers)

Start:
61,420,169 bp from pter      End:
61,472,604 bp from pter
Size:
52,436 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPB7_HUMAN, O75635 (See protein sequence)
Recommended Name: Serpin B7  
Size: 380 amino acids; 42905 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: B4DUW8 F5GZC0 Q1ED45 Q3KPG4
Alternative splicing: 2 isoforms:  O75635-1   O75635-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SERPINB7: NX_O75635

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75635

  • SERPINB7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001035237.1  NP_001248759.1  NP_001248760.1  NP_003775.1  

    ENSEMBL proteins: 
     ENSP00000397301   ENSP00000381101   ENSP00000402362   ENSP00000393947   ENSP00000337212  
     ENSP00000444572   ENSP00000444861  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): SERPINB7
    OriGene Custom Protein Services for SERPINB7 
    GenScript Custom Purified and Recombinant Proteins Services for SERPINB7
    Novus Biologicals SERPINB7 Protein
    Novus Biologicals SERPINB7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SERPINB7

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--


    SERPINB7 for ontologies           About GeneDecksing



    SERPINB7 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SERPINB7 
    GenScript Custom Superior Antibodies Services for SERPINB7
    Novus Biologicals SERPINB7 Antibodies
    Search for Antibodies for SERPINB7 at Abcam  
    Uscn Antibodies for SERPINB7
    Search ThermoFisher Antibodies for SERPINB7

    Assay Products for SERPINB7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SERPINB7
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SERPINB7


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SERPINB7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry O75635

    ProtoNet protein and cluster: O75635

    2 Blocks protein families:
    IPB000215 Serpin
    IPB000240 Maspin signature


    UniProtKB/Swiss-Prot: SPB7_HUMAN, O75635
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SPB7_HUMAN, O75635
    Function: Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes
    via its action as a serpin

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB7
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINB7:
    hsa-miR-548am hsa-miR-493* hsa-miR-548x hsa-miR-2278
    SwitchGear 3'UTR luciferase reporter plasmidSERPINB7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB7 (see all 7)
    OriGene shRNA RFP: SERPINB7
    OriGene siRNA: SERPINB7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SERPINB7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB7 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB7 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SERPINB7 (NM_003784)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SERPINB7
    Search LifeMap BioReagents cell lines for SERPINB7

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB7

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--


    SERPINB7 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERPINB7

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--


    SERPINB7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINB7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINB7
    1 Novoseek chemical compound relationship for SERPINB7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 58.4 18 14586725 (1), 18645605 (1), 11527413 (1), 9710452 (1) (see all 14)

    Search CenterWatch for drugs/clinical trials and news about SERPINB7 / SPB7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERPINB7 gene (4 alternative transcripts): 
    NM_001040147.2  NM_001261830.1  NM_001261831.1  NM_003784.3  

    Unigene Cluster for SERPINB7:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 7
    Hs.138202  [show with all ESTs]
    Unigene Representative Sequence: BX641156
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425392 ENST00000398019(uc002ljm.3 uc010xet.2 uc010dqg.3)
    ENST00000447428 ENST00000431370 ENST00000336429(uc002ljl.3) ENST00000540675
    ENST00000546027

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB7
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINB7:
    hsa-miR-548am hsa-miR-493* hsa-miR-548x hsa-miR-2278
    SwitchGear 3'UTR luciferase reporter plasmidSERPINB7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB7 (see all 7)
    OriGene shRNA RFP: SERPINB7
    OriGene siRNA: SERPINB7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB7
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB7 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB7 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SERPINB7 (NM_003784)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB7 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERPINB7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB7

    Additional cDNA sequence: 

    AF027866.1 AK290673.1 AK290876.1 AK300828.1 BC069417.1 BC069442.1 BC069547.1 BC106743.2 
    BC106744.2 BX641156.1 D88575.1 

    5 DOTS entries:

    DT.102820873  DT.121102852  DT.40296454  DT.101975076  DT.91803422 

    24/30 AceView cDNA sequences (see all 30):

    AI742488 BP371954 BC069547 BC069417 BP374157 AA374189 CB305524 BG319597 
    AI123041 BI335844 BP364497 AI608986 BG682538 BX641156 D88575 AU100197 
    BI871335 BC069442 BF435195 BX284040 BG185954 CA314431 NM_003784 CD702645 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINB7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCCGTCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SERPINB7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    Adult human kidney epithelial cells (Primary Cell)Kidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SERPINB7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINB7

    SOURCE GeneReport for Unigene cluster: Hs.138202

    UniProtKB/Swiss-Prot: SPB7_HUMAN, O75635
    Tissue specificity: Predominantly expressed in mesangial cells

        SABiosciences Custom PCR Arrays for SERPINB7
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERPINB7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINB7 gene from 2/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves F1NHK4_CHICK6
    F1NJA4_CHICK6
    (see all 3)
    Uncharacterized protein
    serine (or cysteine) proteinase inhibitor, clade B...
    (see all 3)
    39(a)
    38(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    2(68937683-68942886)
    2(68923804-68930456)
    zebrafish
    (Danio rerio)
    Actinopterygii serpinb1l16
    zgc:1737296
    (see all 5)
    zgc:173729
    (see all 5)
    40(a)
    35(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    16(54874440-54879870)
    16(54858268-54864487)


    ENSEMBL Gene Tree for SERPINB7 (if available)
    TreeFam Gene Tree for SERPINB7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINB7 gene
    SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  SERPINB32  
    SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINE32  SERPINB132  
    SERPINB82  
    18/28 SIMAP similar genes for SERPINB7 using alignment to 3 protein entries:     SPB7_HUMAN (see all proteins) (see all similar genes):
    DKFZp686D06190    SCCA1    SERPINB11    SERPINB3    SERPINB13    SERPINB4
    SCCA2    SERPINB1    SERPINB10    SERPINB12    SERPINC1    SERPINB6
    SERPINB9    SERPINI1    SERPINI2    SERPINA3    SERPINA5    SERPINB8

    SERPINB7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1146 NCBI SNPs in SERPINB7 are shown (see all 1146    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1457440141,2
    --61418402(+) ACCATC/TCCACA 1 -- us2k10--------
    rs1847983401,2
    --61418458(+) CCATCA/GCCTGC 1 -- us2k10--------
    rs768182101,2
    C,F,--61418572(+) GGAAGT/CTTCCC 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs99481251,2
    C,A,H,--61418658(+) TTTCCA/TAAACT 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1900126461,2
    --61418746(+) CTCACA/GAAGCC 1 -- us2k10--------
    rs170716921,2
    C,F,H,--61418760(+) ACCATA/GTTCAA 1 -- us2k19Minor allele frequency- G:0.02NA NS EA WA 792
    rs1808529841,2
    --61418778(+) GTTAAA/GATGGC 1 -- us2k10--------
    rs177079641,2
    C,F,H,--61418880(+) AGGAAC/TTGTTA 1 -- us2k113Minor allele frequency- T:0.02NA NS EA 1484
    rs1495785441,2
    --61419018(+) TAAAAC/TAGCAT 1 -- us2k10--------
    rs771943001,2
    --61419078(+) GTGACG/ATAAGT 1 -- us2k11Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for SERPINB7 (61420169 - 61472604 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SERPINB7
         2 CNVs: 67377 5059

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINB7
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINB7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SERPINB7 for disorders           About GeneDecksing

    OMIM gene information: 603357    OMIM disorders: --

    9 diseases for SERPINB7:    About MalaCards
    familial encephalopathy with neuroserpin inclusion bodies    iga glomerulonephritis    rhabdoid tumors    nephropathy
    nephritis    glomerulonephritis    kidney disease    ovarian cancer
    lung cancer

    1 disease from the University of Copenhagen DISEASES database for SERPINB7:
    IgA glomerulonephritis

    10 Novoseek disease relationships for SERPINB7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nephropathy iga 80.5 17 10977777 (3), 11527413 (2), 9710452 (2), 16796905 (2) (see all 9)
    diabetic nephropathies 61.6 11 16037283 (4), 17595191 (1), 18363646 (1), 10589701 (1) (see all 6)
    nephrotic syndrome minimal change 60.5 2 11527413 (1), 10589701 (1)
    proteinuria 52.7 1 17595191 (1)
    nephritis 50.2 2 11473647 (2)
    glomerulosclerosis 49.5 3 17595191 (1), 11473647 (1)
    nephropathy membranous 48 2 11527413 (1), 10589701 (1)
    renal disease 47.7 15 17595191 (4), 18645605 (2), 18471408 (2), 15213261 (1) (see all 6)
    renal failure chronic 29.7 2 17595191 (1), 10589701 (1)
    tumors 0 2 12397041 (1)

    Human Genome Epidemiology (HuGE) Navigator: SERPINB7 (8 documents)

    Export disorders for SERPINB7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINB7 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with SERPINB7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy. (PubMed id 9710452)1, 2, 9 Miyata T.... Kurokawa K. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Purification, cDNA cloning, and characterization of a new serpin with megakaryocyte maturation activity. (PubMed id 9182567)1, 2 Tsujimoto M.... Yamaguchi N. (1997)
    4. Transcriptional regulation of a mesangium-predominant gene, megsin. (PubMed id 12397041)1, 9 Inagi R....Kurokawa K. (2002)
    5. The Influence of Two megsin Polymorphisms on the Progression of IgA Nephropathy. (PubMed id 18498720)1, 9 Maixnerova D....Tesar V. (2008)
    6. Mesangial cell-predominant gene, megsin. (PubMed id 12386281)1, 9 Inagi R....Kurokawa K. (2002)
    7. [Correlation between traditional Chinese medicine syndromes in primary immunoglobulin A nephropathy and A267G in 5'-untranslated region within exonal of megsin gene] (PubMed id 18471408)1, 9 Zhong Y.F....Wang Z.H. (2008)
    8. [Association of single nucleotide polymorphism of megsin gene with IgA nephropathy] (PubMed id 16796905)1, 9 Wang Z.H....Han B. (2006)
    9. Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene. (PubMed id 15213261)1, 9 Li Y.J....Wang Y. (2004)
    10. Specific tissue distribution of megsin, a novel serpin, in the glomerulus and its up-regulation in IgA nephropathy. (PubMed id 11527413)1, 9 Inagi R....Kurokawa K. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8710 HGNC: 13902 AceView: SERPINB7 Ensembl:ENSG00000166396 euGenes: HUgn8710
    ECgene: SERPINB7 H-InvDB: SERPINB7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINB7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERPINB7 gene:
    Search GeneIP for patents involving SERPINB7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SERPINB7  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB7   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB7  
     OriGene Protein Over-expression Lysate for SERPINB7   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SERPINB7   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB7   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB7  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SERPINB7   OriGene Custom Protein Services for SERPINB7  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERPINB7
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINB7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB7
     GenScript Custom Purified and Recombinant Proteins Services for SERPINB7 GenScript cDNA clones with any tag delivered in your preferred vector for SERPINB7
     GenScript Custom Assay Services for SERPINB7 GenScript Custom Superior Antibodies Services for SERPINB7
     GenScript Custom overexpressing Cell Line Services for SERPINB7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SERPINB7 promoter
     Search Chromatin IP Primers for SERPINB7
     RT2 qPCR Primer Assay in human, mouse, rat SERPINB7
     Search GNC Networks for SERPINB7
     SABiosciences Custom PCR Arrays for SERPINB7
     Search Tocris compounds for SERPINB7
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SERPINB7 antibodies
     SERPINB7 proteins
     SERPINB7 lysates
     Search for Antibodies for SERPINB7 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SERPINB7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SERPINB7 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SERPINB7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB7
     SwitchGear 3'UTR luciferase reporter plasmids for SERPINB7
     SwitchGear Promoter luciferase reporter plasmids for SERPINB7
     Search ThermoFisher Antibodies for SERPINB7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB7
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SERPINB7 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4