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SERPINB5 Gene

protein-coding   GIFtS: 66
GCID: GC18P061117

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: PI5)
  See SERPINB5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 51 2     PI-52 3
PI51 2 3 5     maspin2
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 51 2     Serpin B52
Protease Inhibitor 5 (Maspin)1 2     Maspin3
Peptidase Inhibitor 52 3     

External Ids:    HGNC: 89491   Entrez Gene: 52682   Ensembl: ENSG000002060757   OMIM: 1547905   UniProtKB: P369523   

Export aliases for SERPINB5 gene to outside databases

Previous GC identifers: GC18P060982 GC18P059293 GC18P059297 GC18P057843


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERPINB5 Gene:
SERPINB5 (serpin peptidase inhibitor, clade B (ovalbumin), member 5) is a protein-coding gene. Diseases associated with SERPINB5 include polymorphous low-grade adenocarcinoma, and bone carcinoma. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952
Function: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it
does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it
exhibits no serine protease inhibitory activity

Gene Wiki entry for SERPINB5 (Maspin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERPINB5 gene promoter:
         C/EBPbeta   p53   AML1a   Sp1   p300   ATF-2   C/EBPalpha   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINB5 promoter sequence
   Search Chromatin IP Primers for SERPINB5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERPINB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.33   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.33

SERPINB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB5 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P061117:  view genomic region     (about GC identifiers)

Start:
61,143,994 bp from pter      End:
61,172,318 bp from pter
Size:
28,325 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952 (See protein sequence)
Recommended Name: Serpin B5  
Size: 375 amino acids; 42100 Da
Subunit: Interacts with IRF6
4 PDB 3D structures from and Proteopedia for SERPINB5:
1WZ9 (3D)        1XQG (3D)        1XQJ (3D)        1XU8 (3D)    
Secondary accessions: B2R6Y4 Q6N0B4 Q8WW89
Alternative splicing: 2 isoforms:  P36952-1   P36952-2   

Explore the universe of human proteins at neXtProt for SERPINB5: NX_P36952

Explore proteomics data for SERPINB5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn99, Asn133, Asn188, Asn361
  • Modification sites at PhosphoSitePlus

  • See SERPINB5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002630.2  
    ENSEMBL proteins: 
     ENSP00000372221   ENSP00000467158   ENSP00000408821  

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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SERPINB5 

     
    antibodies-online proteins for SERPINB5 (18 products) 

     
    antibodies-online peptides for SERPINB5

    SERPINB5 Antibody Products:

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    antibodies-online kits for SERPINB5 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SERPIN: Serine (or cysteine) peptidase inhibitors

    4 InterPro protein domains:
     IPR000240 Serpin_B9/Maspin
     IPR023795 Serpin_CS
     IPR000215 Serpin_fam
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry P36952

    ProtoNet protein and cluster: P36952

    2 Blocks protein domains:
    IPB000215 Serpin
    IPB000240 Maspin signature


    UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    Find genes that share domains with SERPINB5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPB5_HUMAN, P36952
    Function: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it
    does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it
    exhibits no serine protease inhibitory activity

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--
    GO:0005515protein binding IPI16049006
         
    Find genes that share ontologies with SERPINB5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERPINB5:
     Decreased number of cells in m  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Serpinb5):
     cellular  embryogenesis  mortality/aging 

    Find genes that share phenotypes with SERPINB5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Serpinb5tm1Zha for SERPINB5

       genOway: Develop your customized and physiologically relevant rodent model for SERPINB5

    miRNA
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    miRTarBase miRNAs that target SERPINB5:
    hsa-mir-21-5p (MIRT003567), hsa-mir-16-5p (MIRT031536), hsa-mir-30a-5p (MIRT028408), hsa-mir-26b-5p (MIRT029183), hsa-mir-335-5p (MIRT017272), hsa-mir-1 (MIRT002776)

    Block miRNA regulation of human, mouse, rat SERPINB5 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate SERPINB5:
    hsa-miR-16-2* hsa-miR-195* hsa-miR-3190
    SwitchGear 3'UTR luciferase reporter plasmidSERPINB5 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Sino Biological Human cDNA Clone for SERPINB5
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12247) for SERPINB5 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPB5_HUMAN, P36952: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton2
    cytosol2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with SERPINB5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SERPINB5 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    p53 signaling pathway0.41
    2Selected targets of p53
    Selected targets of p53
    3MicroRNAs in cancer
    MicroRNAs in cancer
    4Direct p53 effectors
    Direct p53 effectors
    5ATF-2 transcription factor network
    ATF-2 transcription factor network


    Find genes that share SuperPaths with SERPINB5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for SERPINB5
        Apoptosis and Autophagy
    Angiogenesis

    2 BioSystems Pathways for SERPINB5
        Direct p53 effectors
    ATF-2 transcription factor network



    2 Kegg Pathways  (Kegg details for SERPINB5):
        p53 signaling pathway
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SERPINB5: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SERPINB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for SERPINB5 (P369521, 2, 3 ENSP000003722214) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRSS21Q9Y6M01, 2, 3, ENSP000000059954EBI-2371394,EBI-7054564 MINT-7712188 MINT-7712162 MINT-7712176 MINT-7712215 MINT-7712147 MINT-7712115 MINT-7712128 I2D: score=1 STRING: ENSP00000005995
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    IRF6O148963I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002009morphogenesis of an epithelium IEA--
    GO:0006928cellular component movement TAS8290962
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--
    GO:0030198extracellular matrix organization IEA--

    Find genes that share ontologies with SERPINB5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERPINB5 (SPB5)

    1 DrugBank Compound for SERPINB5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S,S-(2-Hydroxyethyl)Thiocysteine-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for SERPINB5 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 74.3 90 16329135 (2), 18439947 (2), 7797587 (2), 11788595 (1) (see all 81)
    5-aza-2'deoxycytidine 74 18 16457875 (2), 18291368 (2), 14732229 (1), 15063388 (1) (see all 13)
    scca1 66.7 4 14647462 (2), 9817977 (1)
    matrigel 40 3 11601042 (1), 9433491 (1), 8814994 (1)
    depsipeptide 34.7 4 15063388 (3), 12455031 (1)
    vegf 31.8 33 17174141 (7), 16400477 (6), 19462894 (3), 15309707 (3) (see all 12)
    estrogen 25.9 11 15145521 (4), 16625090 (1), 19421758 (1), 16397038 (1) (see all 7)
    pdtc 22.3 2 12964023 (1), 14532972 (1)
    cytosine 17.8 10 10709100 (4), 16457875 (2), 14670180 (1), 12789271 (1)
    p002 15.3 3 16918974 (1), 17174141 (1), 14647462 (1)



    Find genes that share compounds with SERPINB5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SERPINB5 gene: 
    NM_002639.4  

    Unigene Cluster for SERPINB5:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 5
    Hs.55279  [show with all ESTs]
    Unigene Representative Sequence: BX640597
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382771(uc002liz.4) ENST00000489441(uc002liy.2) ENST00000424602
    ENST00000588986 ENST00000465652 ENST00000464346
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    Additional mRNA sequence: 

    AF086216.1 AK301667.1 AK312765.1 BC020713.1 BX640597.1 U04313.1 

    8 DOTS entries:

    DT.97838665  DT.212509  DT.100664178  DT.121103123  DT.95160144  DT.95262537  DT.91674020  DT.121103126 

    Selected AceView cDNA sequences (see all 54):

    BX282484 CB140067 BU623286 CA429745 BM955647 CB119707 T27595 AL701226 
    AL602439 BF056445 NM_002639 AW951580 CB122437 BP352906 CA450305 AL703138 
    CB144455 CB122679 CB122363 AL602554 BC020713 BG741238 BM821493 BM836962 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERPINB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTGTAAAT
    SERPINB5 Expression
    About this image


    SERPINB5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Basal Cells Trachea
             Trachea
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
    SERPINB5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERPINB5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.55279

    UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952
    Tissue specificity: Normal mammary epithelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SERPINB5: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Angiogenesis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SERPINB5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpinb51 , 5 serine (or cysteine) peptidase inhibitor, clade B, more1, 5 86.58(n)1
    89.07(a)1
      1 (50.34 cM)5
    207241  NM_009257.31  NP_033283.11 
     1068611735 
    chicken
    (Gallus gallus)
    Aves SERPINB51 serpin peptidase inhibitor, clade B (ovalbumin), member more 69.42(n)
    64.53(a)
      420900  XM_418986.3  XP_418986.3 
    lizard
    (Anolis carolinensis)
    Reptilia SERPINB56
    serpin peptidase inhibitor, clade B (ovalbumin), m...
    59(a)
    1 ↔ 1
    GL343247.1(1924750-1948671)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia serpinb51 serpin peptidase inhibitor, clade B (ovalbumin), member more 61.87(n)
    53.87(a)
      496735  NM_001011282.1  NP_001011282.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spn63 serpin 30(a)
    (best of 4)
      55B7   --


    ENSEMBL Gene Tree for SERPINB5 (if available)
    TreeFam Gene Tree for SERPINB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERPINB5 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB122  SERPINI22  SERPINB22  SERPINB102  SERPINB32  
    SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINB112  SERPINE32  
    SERPINB132  SERPINB82  
    Selected SIMAP similar genes for SERPINB5 using alignment to 2 protein entries:     SPB5_HUMAN (see all proteins) (see all similar genes):
    SCCA1    PLANH2    SERPINB1    SERPINB3    SERPINB9    SERPINB6
    DKFZp686O07189    SERPINB2    SERPINI2    SERPINB8    SERPINB12    SERPINB11
    SCCA2    SERPINB4    SERPINA1    SERPINB10    SERPINI1    SERPINH1

    Find genes that share paralogs with SERPINB5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERPINB5 (see all 752)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80977741,2
    C,F,H--61142199(+) AATCAC/TCCAAA 1 -- us2k135Minor allele frequency- T:0.28NS NA EA WA CSA 2974
    rs1399508661,2
    --61142345(+) CTCTAC/TCATTT 1 -- us2k10--------
    rs1140598721,2
    F--61142436(+) AATAAC/TATGCT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1493595941,2
    --61142516(+) AGGAAA/GCACAT 1 -- us2k10--------
    rs72443691,2
    C,F,A,H--61142647(+) TGAAGC/ATAAAG 1 -- us2k118Minor allele frequency- A:0.26NS EA NA WA CSA 771
    rs72439521,2
    C,F,H--61142736(+) ATTCTC/TATTTT 1 -- us2k15Minor allele frequency- T:0.04NS EA WA 530
    rs792497731,2
    F--61142957(+) AGTTGC/TTCTTA 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs1833630451,2
    --61142966(+) TATTCA/GTTACT 1 -- us2k10--------
    rs1446652441,2
    --61142978(+) AACAAA/GCACTT 1 -- us2k10--------
    rs1873500271,2
    --61143019(+) CCAAGA/CTTTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SERPINB5 (61143994 - 61172318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SERPINB5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv26779CNV Loss19812545
    nsv131597CNV Loss16902084

    Human Gene Mutation Database (HGMD): SERPINB5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SERPINB5
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINB5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 154790    OMIM disorders: --

    10 diseases for SERPINB5:    
    About MalaCards
    polymorphous low-grade adenocarcinoma    bone carcinoma    laryngeal carcinoma    myoepithelioma
    actinic cheilitis    cheilitis    salivary gland cancer    bladder carcinoma
    prostate cancer    breast cancer


    Find genes that share disorders with SERPINB5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SERPINB5 gene (see all 62)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 68.6 137 17352241 (6), 18367129 (5), 12507299 (4), 16540429 (4) (see all 91)
    tumors 66.6 482 17396143 (8), 16799655 (7), 12011991 (7), 12425757 (6) (see all 99)
    breast cancer 63.8 155 12493023 (8), 16491398 (7), 11440731 (7), 12220518 (6) (see all 63)
    carcinoma 61.2 85 15009909 (5), 18236066 (5), 15608662 (4), 17936671 (4) (see all 39)
    myoepithelioma 60.9 2 12610349 (1), 11795829 (1)
    prostate cancer 57.7 77 12006534 (6), 18931702 (6), 19285254 (6), 17458898 (4) (see all 35)
    cancer 54.9 100 9299418 (3), 14991928 (3), 11309327 (2), 15872371 (2) (see all 63)
    breast carcinoma 53.6 12 9865722 (2), 12425757 (1), 12231537 (1), 17001697 (1) (see all 8)
    adenoma follicular 52.5 4 12964023 (1), 15009909 (1), 16892558 (1), 14532972 (1)
    adenocarcinoma 52 77 17396143 (7), 12969792 (4), 17536309 (4), 15197584 (4) (see all 26)

    Human Genome Epidemiology (HuGE) Navigator: SERPINB5 (2 documents)

    Export disorders for SERPINB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERPINB5 gene, integrated from 10 sources (see all 376):
    (articles sorted by number of sources associating them with SERPINB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. (PubMed id 8290962)1, 2, 3, 9 Zou Z.... Sager R. (Science 1994)
    2. The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. (PubMed id 15760906)1, 2, 9 Law R.H.... Whisstock J.C. (J. Biol. Chem. 2005)
    3. The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin. (PubMed id 7797587)1, 2, 9 Pemberton P.A.... Barr P.J. (J. Biol. Chem. 1995)
    4. Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells. (PubMed id 16720730)1, 3, 9 Cella N....Zhang M. (FASEB J. 2006)
    5. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PubMed id 7724531)1, 3, 9 Schneider S.S.... Silverman G.A. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    6. Update of the human and mouse SERPIN gene superfamily. (PubMed id 24172014)1, 3 Heit C....Vasiliou V. (Hum. Genomics 2013)
    7. Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership. (PubMed id 16049006)1, 2 Bailey C.M....Hendrix M.J.C. (J. Biol. Chem. 2005)
    8. The paradoxical expression of maspin in ovarian carcinoma. (PubMed id 12231537)1, 9 Sood A.K....Hendrix M.J. (Clin. Cancer Res. 2002)
    9. Maspin expression and its clinicopathological significance in tumorigenesis and progression of gastric cancer. (PubMed id 14991928)1, 9 Wang M.C....Li Y. (World J. Gastroenterol. 2004)
    10. Tamoxifen induces the expression of maspin through estrogen receptor-alpha. (PubMed id 15145521)1, 9 Liu Z....Zhang M. (Cancer Lett. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5268 HGNC: 8949 AceView: SERPINB5 Ensembl:ENSG00000206075 euGenes: HUgn5268
    ECgene: SERPINB5 Kegg: 5268 H-InvDB: SERPINB5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERPINB5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERPINB5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERPINB5 gene:
    Search GeneIP for patents involving SERPINB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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