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Aliases for SERPINB5 Gene

Aliases for SERPINB5 Gene

  • Serpin Family B Member 5 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 5 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5 2 3
  • Protease Inhibitor 5 (Maspin) 2 3
  • Peptidase Inhibitor 5 3 4
  • Maspin 3 4
  • PI-5 3 4
  • PI5 3 4
  • Serpin B5 3

External Ids for SERPINB5 Gene

Previous HGNC Symbols for SERPINB5 Gene

  • PI5

Previous GeneCards Identifiers for SERPINB5 Gene

  • GC18P060982
  • GC18P061117
  • GC18P059293
  • GC18P059297
  • GC18P057843

Summaries for SERPINB5 Gene

GeneCards Summary for SERPINB5 Gene

SERPINB5 (Serpin Family B Member 5) is a Protein Coding gene. Diseases associated with SERPINB5 include Syringoma and Bone Squamous Cell Carcinoma. Among its related pathways are Direct p53 effectors and DNA Damage Response. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB1.

UniProtKB/Swiss-Prot for SERPINB5 Gene

  • Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Gene Wiki entry for SERPINB5 Gene

Additional gene information for SERPINB5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB5 Gene

Genomics for SERPINB5 Gene

GeneHancer (GH) Regulatory Elements for SERPINB5 Gene

Promoters and enhancers for SERPINB5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I063475 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 563 +2.3 2270 7.3 KLF1 MAX YY1 ZNF316 POLR2A SMC3 RCOR1 ZSCAN29 NFE2 NFE2L2 SERPINB5 ATP5MC1P6 SERPINB8 ENSG00000269989
GH18I063451 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -23.1 -23139 4.9 MEIS2 KLF1 PKNOX1 FEZF1 E2F1 ZNF335 KLF7 FOS CHD2 TCF7L2 SERPINB5 SERPINB12 SERPINB10 VPS4B
GH18I063443 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.1 -32.0 -31994 3.4 MEIS2 MXI1 PKNOX1 USF1 JUN MAX EBF1 RAD21 RFX5 POLR2A SERPINB5 VPS4B
GH18I063438 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.5 -36.6 -36617 2.5 CTCF ZNF654 ZNF449 TRIM22 MAX REST BATF RAD21 ZNF585B IKZF1 SERPINB5 VPS4B
GH18I063470 Enhancer 0.7 ENCODE dbSUPER 12.8 -4.6 -4587 3.6 MAFF KLF1 POLR2A MAX PRDM10 PRDM1 SERPINB5 VPS4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERPINB5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINB5 gene promoter:

Genomic Locations for SERPINB5 Gene

Genomic Locations for SERPINB5 Gene
chr18:63,476,761-63,505,085
(GRCh38/hg38)
Size:
28,325 bases
Orientation:
Plus strand
chr18:61,143,994-61,172,318
(GRCh37/hg19)

Genomic View for SERPINB5 Gene

Genes around SERPINB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB5 Gene

Proteins for SERPINB5 Gene

  • Protein details for SERPINB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36952-SPB5_HUMAN
    Recommended name:
    Serpin B5
    Protein Accession:
    P36952
    Secondary Accessions:
    • B2R6Y4
    • Q6N0B4
    • Q8WW89

    Protein attributes for SERPINB5 Gene

    Size:
    375 amino acids
    Molecular mass:
    42100 Da
    Quaternary structure:
    • Interacts with IRF6.

    Three dimensional structures from OCA and Proteopedia for SERPINB5 Gene

    Alternative splice isoforms for SERPINB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB5 Gene

Post-translational modifications for SERPINB5 Gene

  • Glycosylation at isoforms=299, isoforms=2133, posLast=188188, and isoforms=361

Other Protein References for SERPINB5 Gene

No data available for DME Specific Peptides for SERPINB5 Gene

Domains & Families for SERPINB5 Gene

Gene Families for SERPINB5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SERPINB5 Gene

Suggested Antigen Peptide Sequences for SERPINB5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36952

UniProtKB/Swiss-Prot:

SPB5_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB5: view

Function for SERPINB5 Gene

Molecular function for SERPINB5 Gene

UniProtKB/Swiss-Prot Function:
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Phenotypes From GWAS Catalog for SERPINB5 Gene

Gene Ontology (GO) - Molecular Function for SERPINB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA,IBA --
GO:0005515 protein binding IPI 16049006
genes like me logo Genes that share ontologies with SERPINB5: view
genes like me logo Genes that share phenotypes with SERPINB5: view

Animal Models for SERPINB5 Gene

MGI Knock Outs for SERPINB5:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINB5 Gene

Localization for SERPINB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB5 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB5 gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SERPINB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,IEA --
GO:0005737 cytoplasm IDA 16049006
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with SERPINB5: view

Pathways & Interactions for SERPINB5 Gene

genes like me logo Genes that share pathways with SERPINB5: view

Pathways by source for SERPINB5 Gene

2 Cell Signaling Technology pathways for SERPINB5 Gene
2 BioSystems pathways for SERPINB5 Gene
2 KEGG pathways for SERPINB5 Gene

Gene Ontology (GO) - Biological Process for SERPINB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002009 morphogenesis of an epithelium IEA --
GO:0006928 movement of cell or subcellular component TAS 8290962
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0030198 extracellular matrix organization IEA --
GO:0050678 regulation of epithelial cell proliferation IEA --
genes like me logo Genes that share ontologies with SERPINB5: view

No data available for SIGNOR curated interactions for SERPINB5 Gene

Drugs & Compounds for SERPINB5 Gene

(9) Drugs for SERPINB5 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S,S-(2-Hydroxyethyl)Thiocysteine Experimental Pharma Target 0

(12) Additional Compounds for SERPINB5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB5: view

Transcripts for SERPINB5 Gene

Unigene Clusters for SERPINB5 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB5 Gene

No ASD Table

Relevant External Links for SERPINB5 Gene

GeneLoc Exon Structure for
SERPINB5
ECgene alternative splicing isoforms for
SERPINB5

Expression for SERPINB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x13.8), Skin - Not Sun Exposed (Suprapubic) (x13.7), Esophagus - Mucosa (x10.4), Minor Salivary Gland (x5.7), and Vagina (x4.4).

Protein differential expression in normal tissues from HIPED for SERPINB5 Gene

This gene is overexpressed in Cervix (20.8) and Oral epithelium (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SERPINB5 Gene



NURSA nuclear receptor signaling pathways regulating expression of SERPINB5 Gene:

SERPINB5

SOURCE GeneReport for Unigene cluster for SERPINB5 Gene:

Hs.55279

mRNA Expression by UniProt/SwissProt for SERPINB5 Gene:

P36952-SPB5_HUMAN
Tissue specificity: Normal mammary epithelial cells.

Evidence on tissue expression from TISSUES for SERPINB5 Gene

  • Intestine(4.4)
  • Lung(3)
  • Skin(2.9)
genes like me logo Genes that share expression patterns with SERPINB5: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB5 Gene

Orthologs for SERPINB5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB5 33 34
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia SERPINB5 33 34
  • 90.22 (n)
cow
(Bos Taurus)
Mammalia SERPINB5 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinb5 33 16 34
  • 86.58 (n)
rat
(Rattus norvegicus)
Mammalia Serpinb5 33
  • 85.96 (n)
oppossum
(Monodelphis domestica)
Mammalia SERPINB5 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINB5 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERPINB5 33 34
  • 69.42 (n)
lizard
(Anolis carolinensis)
Reptilia SERPINB5 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serpinb5 33
  • 61.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta Spn6 35 34
  • 30 (a)
CG6717 35
  • 29 (a)
Spn1 34
  • 29 (a)
ManyToMany
Spn2 34
  • 29 (a)
ManyToMany
Spn3 34
  • 29 (a)
ManyToMany
Spn7 34
  • 28 (a)
ManyToMany
Spn43Ab 35 34
  • 27 (a)
CG7722 35
  • 26 (a)
Spn28Db 34
  • 26 (a)
ManyToMany
Spn28Da 34
  • 25 (a)
ManyToMany
Spn42Dc 34
  • 25 (a)
ManyToMany
Spn43Aa 34
  • 25 (a)
ManyToMany
Spn42De 34
  • 24 (a)
ManyToMany
Spn47C 34
  • 24 (a)
ManyToMany
Spn42Db 34
  • 23 (a)
ManyToMany
Spn4 34
  • 22 (a)
ManyToMany
nec 34
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
Species where no ortholog for SERPINB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINB5 Gene

ENSEMBL:
Gene Tree for SERPINB5 (if available)
TreeFam:
Gene Tree for SERPINB5 (if available)

Paralogs for SERPINB5 Gene

Variants for SERPINB5 Gene

Sequence variations from dbSNP and Humsavar for SERPINB5 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000046856 -- 63,496,530(+) T/C intron_variant
rs1000147541 -- 63,487,356(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000158872 -- 63,487,693(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000164703 -- 63,479,530(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000259247 -- 63,481,220(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINB5 Gene

Variant ID Type Subtype PubMed ID
esv26779 CNV loss 19812545
esv2763190 CNV loss 21179565
esv3334527 CNV duplication 20981092
nsv1066552 CNV gain 25217958
nsv131597 CNV deletion 16902084

Variation tolerance for SERPINB5 Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.19; 96.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINB5 Gene

Human Gene Mutation Database (HGMD)
SERPINB5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB5 Gene

Disorders for SERPINB5 Gene

MalaCards: The human disease database

(25) MalaCards diseases for SERPINB5 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
syringoma
  • syringomas
bone squamous cell carcinoma
mandibular cancer
  • malignant neoplasm of inferior maxilla
pleomorphic adenoma
  • mixed tumor of the salivary gland
salivary gland cancer
  • malignant neoplasm of major salivary gland
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERPINB5

genes like me logo Genes that share disorders with SERPINB5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB5 Gene

Publications for SERPINB5 Gene

  1. Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells. (PMID: 16720730) Cella N … Zhang M (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 2 3 22 58
  2. The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. (PMID: 15760906) Law RH … Whisstock JC (The Journal of biological chemistry 2005) 3 4 22 58
  3. The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin. (PMID: 7797587) Pemberton PA … Barr PJ (The Journal of biological chemistry 1995) 3 4 22 58
  4. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. (PMID: 8290962) Zou Z … Sager R (Science (New York, N.Y.) 1994) 2 3 4 58
  5. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3 58

Products for SERPINB5 Gene

Sources for SERPINB5 Gene

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