Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SERPINB5 Gene

protein-coding GIFtS: 65
GCID: GC18P061117

serpin peptidase inhibitor, clade B (ovalbumin), member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: PI5)

Explore 70 diseases affiliated with
SERPINB5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5¹ ²		PI-5² ³
PI5¹ ² ³ ⁵		Protease Inhibitor 5 (Maspin)²
Maspin³		Serpin B5²
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 5¹ ²		Maspin³
Peptidase Inhibitor 5² ³

External Ids:	HGNC: 8949¹	Entrez Gene: 5268²	Ensembl: ENSG00000206075⁷	OMIM: 154790⁵	UniProtKB: P36952³

Export aliases for SERPINB5 gene to outside databases

Previous GC identifers: GC18P060982 GC18P059293 GC18P059297 GC18P057843

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952

Function: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not

undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no

serine protease inhibitory activity

Gene Wiki entry for SERPINB5 (Maspin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_025028.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SERPINB5 gene promoter:
C/EBPbeta p53 AML1a Sp1 p300 ATF-2 C/EBPalpha HFH-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SERPINB5 promoter sequence

Search SABiosciences Chromatin IP Primers for SERPINB5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.33 Ensembl cytogenetic band: 18q21.33 HGNC cytogenetic band: 18q21.33

SERPINB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB5 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P061117: view genomic region (about GC identifiers)

Start:	61,143,994 bp from pter	End:	61,172,318 bp from pter
Size:	28,325 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952 (See protein sequence)

Recommended Name: Serpin B5

Size: 375 amino acids; 42100 Da

Subunit: Interacts with IRF6

Subcellular location: Secreted, extracellular space

4 PDB 3D structures from and Proteopedia for SERPINB5:

1WZ9 (3D)

1XQG (3D)

1XQJ (3D)

1XU8 (3D)

Secondary accessions: B2R6Y4 Q6N0B4 Q8WW89

Alternative splicing: 2 isoforms: P36952-1 P36952-2

Explore the universe of human proteins at neXtProt for SERPINB5: NX_P36952

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P36952

SERPINB5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002630.2

ENSEMBL proteins:

ENSP00000372221 ENSP00000467158 ENSP00000408821

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SERPINB5 OriGene Protein Over-expression Lysate: SERPINB5 OriGene Custom Protein Services for SERPINB5
	GenScript Custom Purified and Recombinant Proteins Services for SERPINB5
	Novus Biologicals SERPINB5 Proteins Novus Biologicals SERPINB5 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for SERPINB5
	Uscn Proteins for SERPINB5

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	IDA	--

SERPINB5 for ontologies About GeneDecksing

SERPINB5 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SERPINB5
	R&D Systems Antibodies for SERPINB5 (Serpin B5/Maspin)
	Cell Signaling Technology (CST) Antibodies for SERPINB5 (maspin)
	OriGene Antibodies: SERPINB5 OriGene Custom Antibody Services for SERPINB5
	GenScript Custom Superior Antibodies Services for SERPINB5
	Novus Biologicals SERPINB5 Antibodies
	Search for Antibodies for SERPINB5 at Abcam
	Uscn Antibodies for SERPINB5
	ThermoFisher Antibodies for SERPINB5

Assay Products for SERPINB5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for SERPINB5 (Serpin B5/Maspin)
	GenScript Custom Assay Services for SERPINB5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SERPINB5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SERPINB5 for domains About GeneDecksing

4 InterPro domains/families:

IPR000240 Serpin_B9/Maspin

IPR023795 Protease_inhib_I4_serpin_CS

IPR023796 Serpin_dom

IPR000215 Serpin_fam

Graphical View of Domain Structure for InterPro Entry P36952

ProtoNet protein and cluster: P36952

2 Blocks protein families:

IPB000215 Serpin

IPB000240 Maspin signature

UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952

Similarity: Belongs to the serpin family. Ov-serpin subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952

Function: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not

undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no

serine protease inhibitory activity

miRNA Products:		miRTarBase miRNAs that target SERPINB5: hsa-mir-21 (MIRT003567), hsa-mir-1 (MIRT002776)

		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB5
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINB5:
		hsa-miR-16-2* hsa-miR-195* hsa-miR-3190
		SwitchGear 3'UTR luciferase reporter plasmid: SERPINB5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB5 (see all 7) OriGene shRNA RFP: SERPINB5 OriGene siRNA: SERPINB5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB5

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SERPINB5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB5 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SERPINB5 (NM_002639)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SERPINB5
		Search LifeMap BioReagents cell lines for SERPINB5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB5

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004867	serine-type endopeptidase inhibitor activity	IBA	--
GO:0005515	protein binding	IPI	16049006

SERPINB5 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SERPINB5:

Decreased number of cells in m

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Serpinb5^tm1Zha for SERPINB5
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Serpinb5):

cellular

embryogenesis

mortality/aging

SERPINB5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Angiogenesis

Angiogenesis

1.00

ATF-2 transcription factor network

ATF-2 transcription factor network

1.00

Direct p53 effectors

Direct p53 effectors

1.00

p53 signaling pathway

p53 signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SERPINB5

Selected targets of p53

2 Cell Signaling Technology (CST) Pathways for SERPINB5

	Apoptosis and Autophagy
	Angiogenesis

2 BioSystems Pathways for SERPINB5

	Direct p53 effectors
	ATF-2 transcription factor network

1 Kegg Pathway (Kegg details for SERPINB5):

p53 signaling pathway

SERPINB5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SERPINB5

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/7 Interacting proteins for SERPINB5 (P36952^{2, 3} ENSP00000372221⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRSS21	Q9Y6M0²^,³, ENSP00000005995⁴	MINT-7712188 MINT-7712162 MINT-7712176 MINT-7712215 MINT-7712147 MINT-7712115 MINT-7712128 I2D: score=1 STRING: ENSP00000005995
SLX4	Q8IY92³, ENSP00000294008⁴	I2D: score=1 STRING: ENSP00000294008
HDAC1	Q13547³, ENSP00000362649⁴	I2D: score=1 STRING: ENSP00000362649
UCHL5	Q9Y5K5³, ENSP00000356425⁴	I2D: score=1 STRING: ENSP00000356425
IRF6	O14896³	I2D: score=1

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002009	morphogenesis of an epithelium	IEA	--
GO:0006928	cellular component movement	TAS	8290962
GO:0010951	negative regulation of endopeptidase activity	IBA	--
GO:0030162	regulation of proteolysis	IBA	--
GO:0030198	extracellular matrix organization	IEA	--

SERPINB5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SERPINB5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SERPINB5

1 DrugBank Compound for SERPINB5 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
S,S-(2-Hydroxyethyl)Thiocysteine	--	--	target	--	17139284 17016423

10/20 Novoseek chemical compound relationships for SERPINB5 gene (see all 20) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	74.3	90	16329135 (2), 18439947 (2), 7797587 (2), 11788595 (1) (see all 81)
5-aza-2'deoxycytidine	74	18	16457875 (2), 18291368 (2), 14732229 (1), 15063388 (1) (see all 13)
scca1	66.7	4	14647462 (2), 9817977 (1)
matrigel	40	3	11601042 (1), 9433491 (1), 8814994 (1)
depsipeptide	34.7	4	15063388 (3), 12455031 (1)
vegf	31.8	33	17174141 (7), 16400477 (6), 19462894 (3), 15309707 (3) (see all 12)
estrogen	25.9	11	15145521 (4), 16625090 (1), 19421758 (1), 16397038 (1) (see all 7)
pdtc	22.3	2	12964023 (1), 14532972 (1)
cytosine	17.8	10	10709100 (4), 16457875 (2), 14670180 (1), 12789271 (1)
p002	15.3	3	16918974 (1), 17174141 (1), 14647462 (1)

Search CenterWatch for drugs/clinical trials and news about SERPINB5 / SPB5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SERPINB5 gene:

NM_002639.4

Unigene Cluster for SERPINB5:

Serpin peptidase inhibitor, clade B (ovalbumin), member 5

Hs.55279 [show with all ESTs]

Unigene Representative Sequence: BX640597

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000382771(uc002liz.4) ENST00000489441(uc002liy.2) ENST00000424602

ENST00000588986 ENST00000465652 ENST00000464346

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB5
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINB5:
		hsa-miR-16-2* hsa-miR-195* hsa-miR-3190
		SwitchGear 3'UTR luciferase reporter plasmid: SERPINB5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB5 (see all 7) OriGene shRNA RFP: SERPINB5 OriGene siRNA: SERPINB5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB5 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SERPINB5 (NM_002639)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SERPINB5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB5

Additional cDNA sequence:

AF086216.1 AK301667.1 AK312765.1 BC020713.1 BX640597.1 U04313.1

8 DOTS entries:

DT.97838665 DT.212509 DT.100664178 DT.121103123 DT.95160144 DT.95262537 DT.91674020 DT.121103126

24/54 AceView cDNA sequences (see all 54):

BX282484 CB140067 CB122679 T27595 CB122363 AL701226 BC020713 AW951580

CB122437 BF056445 AI989728 AL602439 BM836962 CA450305 AL703138 CB144455

BM821493 BG741238 BQ228585 BG677400 CA429745 BU685516 BM955647 AL602554

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SERPINB5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTGTAAAT

About this image

SERPINB5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Sertoli cells

Testis

Lung

Trachea

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SERPINB5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SERPINB5

SOURCE GeneReport for Unigene cluster: Hs.55279

UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952

Tissue specificity: Normal mammary epithelial cells

SABiosciences Expression via Pathway-Focused PCR Arrays including SERPINB5:

Oncogenes & Tumor Suppressor Genes in human mouse rat

p53 Signaling Pathway in human mouse rat

Angiogenesis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SERPINB5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERPINB5 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SERPINB5¹	serpin peptidase inhibitor, clade B (ovalbumin), member more	69.42(n) 64.53(a)		420900 XM_418986.2 XP_418986.2
lizard (Anolis carolinensis)	Reptilia	SERPINB5⁶ -- (see all 3)	--	59(a) 30(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	GL343247.1(1924750-1937174) GL343247.1(1728142-1737245)
fruit fly (Drosophila melanogaster)	Insecta	Spn6³	serpin	30(a) (best of 4)		55B7 --
worm (Caenorhabditis elegans)	Secernentea	srp-1⁶ srp-2⁶ (see all 6)	SeRPin family member (srp-2) (see all 6)	23(a) 23(a) (see all 6)	possible ortholog possible ortholog (see all 6)	V(753335-755049) V(762735-764658)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G64010⁶ AT1G47710⁶ (see all 10)	serpin-ZX (see all 10)	24(a) 23(a) (see all 10)	many ↔ many many ↔ many (see all 10)	1(23750884-23751441) 1(17558209-17560269)
rice (Oryza sativa)	Liliopsida	-- -- (see all 16)	serpin domain containing protein, putative, expres... serpin domain containing protein, putative, expres... (see all 16)	25(a) 22(a) (see all 16)	many ↔ many many ↔ many (see all 16)	3(23053071-23066803) 11(6388536-6390505)

ENSEMBL Gene Tree for SERPINB5 (if available)
TreeFam Gene Tree for SERPINB5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SERPINB5 gene

SERPINB7² SERPINB1² SERPINI1² SERPINB12² SERPINI2² SERPINB2² SERPINB10² SERPINB3²

SERPINB4² SERPINE2² SERPINB6² SERPINC1² SERPINB9² SERPINE1² SERPINE3² SERPINB13²

SERPINB8²

18/27 SIMAP similar genes for SERPINB5 using alignment to 2 protein entries: SPB5_HUMAN (see all proteins) (see all similar genes):

SCCA1 PLANH2 SERPINB1 SERPINB3 SERPINB9 DKFZp686O07189

SERPINB2 SERPINB6 SERPINI2 SERPINB8 SERPINB12 SERPINB11

SCCA2 SERPINB4 SERPINA1 SERPINB10 SERPINI1 SERPINH1

SERPINB5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8097774^1,2	C,F,H,	--	61142199(+)	`AATCAC/TCCAAA`	1	--	us2k¹		35		NS NA EA WA CSA	2974
rs139950866^1,2		--	61142345(+)	`CTCTAC/TCATTT`	1	--	us2k¹		0	--	--	--	--
rs114059872^1,2		--	61142436(+)	`AATAAC/TATGCT`	1	--	us2k¹		1		WA	118
rs149359594^1,2		--	61142516(+)	`AGGAAA/GCACAT`	1	--	us2k¹		0	--	--	--	--
rs7244369^1,2	C,F,A,H,	--	61142647(+)	`TGAAGC/ATAAAG`	1	--	us2k¹		18		NS EA NA WA CSA	771
rs7243952^1,2	C,F,H,	--	61142736(+)	`ATTCTC/TATTTT`	1	--	us2k¹		5		NS EA WA	530
rs79249773^1,2	F,	--	61142957(+)	`AGTTGC/TTCTTA`	1	--	us2k¹		1		WA	118
rs183363045^1,2		--	61142966(+)	`TATTCA/GTTACT`	1	--	us2k¹		0	--	--	--	--
rs144665244^1,2		--	61142978(+)	`AACAAA/GCACTT`	1	--	us2k¹		0	--	--	--	--
rs187350027^1,2		--	61143019(+)	`CCAAGA/CTTTGG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SERPINB5 (61143994 - 61172318 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SERPINB5
2 CNVs: 5918 73157
Human Gene Mutation Database (HGMD): SERPINB5

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINB5

DNA2.0 Custom Variant and Variant Library Synthesis for SERPINB5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SERPINB5 for disorders           About GeneDecksing

OMIM gene information: 154790    OMIM disorders: --

20/70 diseases for SERPINB5 (see all 70):    About MalaCards

actinic cheilitis salivary gland cancer myoepithelioma cheilitis

gastrointestinal stromal tumor carcinoma adenoid cystic carcinoma oral squamous cell carcinoma

edwards syndrome squamous cell carcinoma adenoiditis pancreatic ductal adenocarcinoma

pleomorphic adenoma inflammatory bowel disease papillary thyroid carcinoma chronic lymphocytic leukemia

laryngeal carcinoma bladder carcinoma intrahepatic cholangiocarcinoma epithelial ovarian cancer

10/62 Novoseek disease relationships for SERPINB5 gene (see all 62) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	68.6	137	17352241 (6), 18367129 (5), 12507299 (4), 16540429 (4) (see all 91)
tumors	66.6	482	17396143 (8), 16799655 (7), 12011991 (7), 12425757 (6) (see all 99)
breast cancer	63.8	155	12493023 (8), 16491398 (7), 11440731 (7), 12220518 (6) (see all 63)
carcinoma	61.2	85	15009909 (5), 18236066 (5), 15608662 (4), 17936671 (4) (see all 39)
myoepithelioma	60.9	2	12610349 (1), 11795829 (1)
prostate cancer	57.7	77	12006534 (6), 18931702 (6), 19285254 (6), 17458898 (4) (see all 35)
cancer	54.9	100	9299418 (3), 14991928 (3), 11309327 (2), 15872371 (2) (see all 63)
breast carcinoma	53.6	12	9865722 (2), 12425757 (1), 12231537 (1), 17001697 (1) (see all 8)
adenoma follicular	52.5	4	12964023 (1), 15009909 (1), 16892558 (1), 14532972 (1)
adenocarcinoma	52	77	17396143 (7), 12969792 (4), 17536309 (4), 15197584 (4) (see all 26)

Human Genome Epidemiology (HuGE) Navigator: SERPINB5 (2 documents)

Export disorders for SERPINB5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SERPINB5 gene, integrated from 9 sources (see all 365):
(articles sorted by number of sources associating them with SERPINB5)

Utopia: connect your pdf to the dynamic
world of online information

Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. (PubMed id 8290962)^{1, 2, 3, 9} Zou Z.... Sager R. (1994)
The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. (PubMed id 15760906)^{1, 2, 9} Law R.H.... Whisstock J.C. (2005)
The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin. (PubMed id 7797587)^{1, 2, 9} Pemberton P.A.... Barr P.J. (1995)
Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells. (PubMed id 16720730)^{1, 3, 9} Cella N....Zhang M. (2006)
A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PubMed id 7724531)^{1, 3, 9} Schneider S.S.... Silverman G.A. (1995)
Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership. (PubMed id 16049006)^{1, 2} Bailey C.M....Hendrix M.J.C. (2005)
The paradoxical expression of maspin in ovarian carcinoma. (PubMed id 12231537)^{1, 9} Sood A.K....Hendrix M.J. (2002)
Maspin expression and its clinicopathological significance in tumorigenesis and progression of gastric cancer. (PubMed id 14991928)^{1, 9} Wang M.C....Li Y. (2004)
Tamoxifen induces the expression of maspin through estrogen receptor-alpha. (PubMed id 15145521)^{1, 9} Liu Z....Zhang M. (2004)
Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin. (PubMed id 11751384)^{1, 9} Biliran H. and Sheng S. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5268	HGNC: 8949	AceView: SERPINB5	Ensembl:ENSG00000206075	euGenes: HUgn5268
ECgene: SERPINB5	Kegg: 5268	H-InvDB: SERPINB5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SERPINB5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SERPINB5	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SERPINB5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SERPINB5 gene:
Search GeneIP for patents involving SERPINB5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of SERPINB5
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for SERPINB5 (Serpin B5/Maspin)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for SERPINB5 (Serpin B5/Maspin)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for SERPINB5		OriGene shRNA RFP for SERPINB5
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB5		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB5
	OriGene Protein Over-expression Lysate for SERPINB5		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SERPINB5		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB5		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB5
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for SERPINB5		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SERPINB5		OriGene Custom Protein Services for SERPINB5
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERPINB5
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINB5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB5
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB5
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB5

	GenScript Custom Purified and Recombinant Proteins Services for SERPINB5		GenScript cDNA clones with any tag delivered in your preferred vector for SERPINB5
	GenScript Custom Assay Services for SERPINB5		GenScript Custom Superior Antibodies Services for SERPINB5
	GenScript Custom overexpressing Cell Line Services for SERPINB5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for SERPINB5 (maspin)

	Regulatory tfbs in SERPINB5 promoter
	Search Chromatin IP Primers for SERPINB5
	RT² qPCR Primer Assay in human, mouse, rat SERPINB5
	GNC Network for SERPINB5
	SABiosciences PCR Arrays including human, mouse, rat SERPINB5

Search Tocris compounds for SERPINB5

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SERPINB5 antibodies
	SERPINB5 proteins
	SERPINB5 lysates

	Search for Antibodies for SERPINB5 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SERPINB5
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for SERPINB5

SERPINB5 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SERPINB5

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB5

	SwitchGear 3'UTR luciferase reporter plasmids for SERPINB5
	SwitchGear Promoter luciferase reporter plasmids for SERPINB5

ThermoFisher Antibodies for SERPINB5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB5

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SERPINB5 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SERPINB5 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member...

Aliases
for SERPINB5 gene

Summaries
for SERPINB5 gene

Genomic Views
for SERPINB5 gene

Proteins
for SERPINB5 gene

Protein Domains /
Families
for SERPINB5 gene

Function
for SERPINB5 gene

Pathways & Interactions
for SERPINB5 gene

Drugs & Compounds
for SERPINB5 gene

Transcripts
for SERPINB5 gene

Expression
for SERPINB5 gene

Orthologs
for SERPINB5 gene

Paralogs
for SERPINB5 gene

Genomic Variants
for SERPINB5 gene

Disorders / Diseases
for SERPINB5 gene

Publications
for SERPINB5 gene

External Searches for SERPINB5 gene

Genome Databases showing SERPINB5 gene

Other Databases showing SERPINB5 gene

Specialized Databases showing SERPINB5 gene

Intellectual Property
for SERPINB5 gene

Products
for SERPINB5 gene

View Random Gene

Gastric Cancer
BREAST CARCINOMA
Melanoma
Colon Cancer
bladder cancer
Microsatellite Instability
Adenoma Follicular
Hyperplasia
dysplasia
BONE TUMOR
Carcinoma
aggressiveness
Thyroid Cancer
epithelial tumor
PROSTATE CARCINOMA
LARYNGEAL CARCINOMA
Breast Cancer
Metaplasia
primary tumor
NSCLC
Carcinoma Papillary
Adenoma Pleomorphic
Adenocarcinoma
HEPATOCELLULAR CARCINOMA
THYROID PAPILLARY CARCINOMA
Cancer
Pancreatic Cancer
Colorectal Carcinoma
Cancer Lung
chronic pancreatitis
ADENOCARCINOMA GASTRIC
mammary tumor
GASTRIC CARCINOMA
Ovarian Cancer
Carcinoma Undifferentiated
Shock
Pancreatic tumor
Precancerous lesions
Adenoma
Colorectal Cancer
Carcinoma Adenoid Cystic
OVARIAN CARCINOMA
Inflammation
Thyroid Neoplasms
invasive cancer
Carcinoma Squamous Cell
Bladder Tumors
Carcinoma Intraductal
BLADDER CARCINOMA
PANCREATIC CARCINOMA
prostate cancer
Tumors
Carcinoma Lobular
Metastasis
residual disease
Carcinoma Ductal
Sarcoma
breast cancer metastatic
THYROID CARCINOMA
Endometrial Cancer
Myoepithelioma
Choriocarcinoma

Advanced Search

Export list of displayed genes

SERPINB5 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member...

Aliasesfor SERPINB5 gene

Summariesfor SERPINB5 gene

Genomic Viewsfor SERPINB5 gene

Proteinsfor SERPINB5 gene

Protein Domains /Familiesfor SERPINB5 gene

Functionfor SERPINB5 gene

Pathways & Interactionsfor SERPINB5 gene

Drugs & Compoundsfor SERPINB5 gene

Transcriptsfor SERPINB5 gene

Expression for SERPINB5 gene

Orthologsfor SERPINB5 gene

Paralogsfor SERPINB5 gene

Genomic Variantsfor SERPINB5 gene

Disorders / Diseasesfor SERPINB5 gene

Publicationsfor SERPINB5 gene

External Searches for SERPINB5 gene

Genome Databases showing SERPINB5 gene

Other Databases showing SERPINB5 gene

Specialized Databases showing SERPINB5 gene

Intellectual Propertyfor SERPINB5 gene

Productsfor SERPINB5 gene

View Random Gene

Aliases
for SERPINB5 gene

Summaries
for SERPINB5 gene

Genomic Views
for SERPINB5 gene

Proteins
for SERPINB5 gene

Protein Domains /
Families
for SERPINB5 gene

Function
for SERPINB5 gene

Pathways & Interactions
for SERPINB5 gene

Drugs & Compounds
for SERPINB5 gene

Transcripts
for SERPINB5 gene

Expression
for SERPINB5 gene

Orthologs
for SERPINB5 gene

Paralogs
for SERPINB5 gene

Genomic Variants
for SERPINB5 gene

Disorders / Diseases
for SERPINB5 gene

Publications
for SERPINB5 gene

Intellectual Property
for SERPINB5 gene

Products
for SERPINB5 gene