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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINB5 Gene

protein-coding   GIFtS: 66
GCID: GC18P061117

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: PI5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 51 2     PI-52 3
PI51 2 3 5     maspin2
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 51 2     Serpin B52
Protease Inhibitor 5 (Maspin)1 2     Maspin3
Peptidase Inhibitor 52 3     

External Ids:    HGNC: 89491   Entrez Gene: 52682   Ensembl: ENSG000002060757   OMIM: 1547905   UniProtKB: P369523   

Export aliases for SERPINB5 gene to outside databases

Previous GC identifers: GC18P060982 GC18P059293 GC18P059297 GC18P057843


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SERPINB5 Gene: 
SERPINB5 (serpin peptidase inhibitor, clade B (ovalbumin), member 5) is a protein-coding gene. Diseases associated with SERPINB5 include gastric adenocarcinoma, and pancreatic ductal adenocarcinoma, and among its related super-pathways are DNA damage response. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and protein binding. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952
Function: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it
does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it
exhibits no serine protease inhibitory activity

Gene Wiki entry for SERPINB5 (Maspin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.2  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINB5 gene promoter:
         C/EBPbeta   p53   AML1a   Sp1   p300   ATF-2   C/EBPalpha   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINB5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINB5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.33   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.33

SERPINB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB5 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P061117:  view genomic region     (about GC identifiers)

Start:
61,143,994 bp from pter      End:
61,172,318 bp from pter
Size:
28,325 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952 (See protein sequence)
Recommended Name: Serpin B5  
Size: 375 amino acids; 42100 Da
Subunit: Interacts with IRF6
Subcellular location: Secreted, extracellular space
4 PDB 3D structures from and Proteopedia for SERPINB5:
1WZ9 (3D)        1XQG (3D)        1XQJ (3D)        1XU8 (3D)    
Secondary accessions: B2R6Y4 Q6N0B4 Q8WW89
Alternative splicing: 2 isoforms:  P36952-1   P36952-2   

Explore the universe of human proteins at neXtProt for SERPINB5: NX_P36952

Explore proteomics data for SERPINB5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P36952

  • SERPINB5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERPINB5 Protein Expression
    REFSEQ proteins: NP_002630.2  
    ENSEMBL proteins: 
     ENSP00000372221   ENSP00000467158   ENSP00000408821  

    Human Recombinant Protein Products for SERPINB5: 
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    Novus Biologicals SERPINB5 Proteins
    Novus Biologicals SERPINB5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SERPINB5
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IDA--

    SERPINB5 for ontologies           About GeneDecksing



    SERPINB5 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SERPINB5 

    Assay Products for SERPINB5: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SERPIN: Serine (or cysteine) peptidase inhibitors

    4 InterPro protein domains:
     IPR000240 Serpin_B9/Maspin
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P36952

    ProtoNet protein and cluster: P36952

    2 Blocks protein domains:
    IPB000215 Serpin
    IPB000240 Maspin signature


    UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    SERPINB5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPB5_HUMAN, P36952
    Function: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it
    does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it
    exhibits no serine protease inhibitory activity

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--
    GO:0005515protein binding IPI16049006
         
    SERPINB5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERPINB5:
     Decreased number of cells in m  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Serpinb5):
     cellular  embryogenesis  mortality/aging 

    SERPINB5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Serpinb5tm1Zha for SERPINB5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SERPINB5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERPINB5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINB5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERPINB5 

    miRNA
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    miRTarBase miRNAs that target SERPINB5:
    hsa-mir-21 (MIRT003567), hsa-mir-1 (MIRT002776)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB5
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINB5:
    hsa-miR-16-2* hsa-miR-195* hsa-miR-3190
    SwitchGear 3'UTR luciferase reporter plasmidSERPINB5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SERPINB5 (NM_002639)
    Sino Biological Human cDNA Clone for SERPINB5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB5
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                         Customized lentivirus expression plasmids for stable overexpression of SERPINB5 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SERPINB5 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    p53 signaling pathway0.41
    2MicroRNAs in cancer
    MicroRNAs in cancer
    3Direct p53 effectors
    Direct p53 effectors
    4Apoptosis and Autophagy
    Apoptosis and Autophagy
    5Angiogenesis
    Angiogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SERPINB5
        Selected targets of p53


    2 Cell Signaling Technology (CST) Pathways for SERPINB5
        Apoptosis and Autophagy
    Angiogenesis

    2 BioSystems Pathways for SERPINB5
        ATF-2 transcription factor network
    Direct p53 effectors



    2         Kegg Pathways  (Kegg details for SERPINB5):
        p53 signaling pathway
    MicroRNAs in cancer


    SERPINB5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for SERPINB5 (P369522, 3 ENSP000003722214) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRSS21Q9Y6M02, 3, ENSP000000059954MINT-7712188 MINT-7712162 MINT-7712176 MINT-7712215 MINT-7712147 MINT-7712115 MINT-7712128 I2D: score=1 STRING: ENSP00000005995
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    IRF6O148963I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002009morphogenesis of an epithelium IEA--
    GO:0006928cellular component movement TAS8290962
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--
    GO:0030198extracellular matrix organization IEA--

    SERPINB5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINB5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINB5 (SPB5)

    1 DrugBank Compound for SERPINB5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S,S-(2-Hydroxyethyl)Thiocysteine-- --target--17139284 17016423

    10/20 Novoseek inferred chemical compound relationships for SERPINB5 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 74.3 90 16329135 (2), 18439947 (2), 7797587 (2), 11788595 (1) (see all 81)
    5-aza-2'deoxycytidine 74 18 16457875 (2), 18291368 (2), 14732229 (1), 15063388 (1) (see all 13)
    scca1 66.7 4 14647462 (2), 9817977 (1)
    matrigel 40 3 11601042 (1), 9433491 (1), 8814994 (1)
    depsipeptide 34.7 4 15063388 (3), 12455031 (1)
    vegf 31.8 33 17174141 (7), 16400477 (6), 19462894 (3), 15309707 (3) (see all 12)
    estrogen 25.9 11 15145521 (4), 16625090 (1), 19421758 (1), 16397038 (1) (see all 7)
    pdtc 22.3 2 12964023 (1), 14532972 (1)
    cytosine 17.8 10 10709100 (4), 16457875 (2), 14670180 (1), 12789271 (1)
    p002 15.3 3 16918974 (1), 17174141 (1), 14647462 (1)

    Search CenterWatch for drugs/clinical trials and news about SERPINB5 / SPB5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERPINB5 gene: 
    NM_002639.4  

    Unigene Cluster for SERPINB5:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 5
    Hs.55279  [show with all ESTs]
    Unigene Representative Sequence: BX640597
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382771(uc002liz.4) ENST00000489441(uc002liy.2) ENST00000424602
    ENST00000588986 ENST00000465652 ENST00000464346
    miRNA
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    hsa-miR-16-2* hsa-miR-195* hsa-miR-3190
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF086216.1 AK301667.1 AK312765.1 BC020713.1 BX640597.1 U04313.1 

    8 DOTS entries:

    DT.97838665  DT.212509  DT.100664178  DT.121103123  DT.95160144  DT.95262537  DT.91674020  DT.121103126 

    24/54 AceView cDNA sequences (see all 54):

    CB140067 BX282484 BQ217236 CA429745 BG677400 AL602554 BQ228585 CB122437 
    NM_002639 BG402793 CB119707 BM836962 BG677096 AW951580 CA450305 U04313 
    BF056445 AA294992 AL701226 BM955647 BU623286 CB144455 AL703138 BP352906 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINB5 expression in normal human tissues (normalized intensities)      SERPINB5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTGTAAAT
    SERPINB5 Expression
    About this image


    SERPINB5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Epithelium
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Trachea
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Oral Cavity (Integumentary System)    fully expand to see all 3 entries
             Human Oral Keritinocytes (HOK)   
             mouth   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/naso-lacrimal duct   

    See SERPINB5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINB5

    SOURCE GeneReport for Unigene cluster: Hs.55279

    UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952
    Tissue specificity: Normal mammary epithelial cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including SERPINB5: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Angiogenesis in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SERPINB5 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpinb51 , 5 serine (or cysteine) peptidase inhibitor, clade B, more1, 5 86.58(n)1
    89.07(a)1
      1 (50.34 cM)5
    207241  NM_009257.31  NP_033283.11 
     1068611735 
    chicken
    (Gallus gallus)
    Aves SERPINB51 serpin peptidase inhibitor, clade B (ovalbumin), member more 69.42(n)
    64.53(a)
      420900  XM_418986.2  XP_418986.2 
    lizard
    (Anolis carolinensis)
    Reptilia SERPINB56
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    59(a)
    28(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    GL343247.1(1924750-1948671)
    GL343247.1(1727253-1737245)
    fruit fly
    (Drosophila melanogaster)
    Insecta Spn63 serpin 30(a)
    (best of 4)
      55B7   --


    ENSEMBL Gene Tree for SERPINB5 (if available)
    TreeFam Gene Tree for SERPINB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINB5 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB122  SERPINI22  SERPINB22  SERPINB102  SERPINB32  
    SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINB112  SERPINE32  
    SERPINB132  SERPINB82  
    18/27 SIMAP similar genes for SERPINB5 using alignment to 2 protein entries:     SPB5_HUMAN (see all proteins) (see all similar genes):
    SCCA1    PLANH2    SERPINB1    SERPINB3    SERPINB9    SERPINB6
    DKFZp686O07189    SERPINB2    SERPINI2    SERPINB8    SERPINB12    SERPINB11
    SCCA2    SERPINB4    SERPINA1    SERPINB10    SERPINI1    SERPINH1

    SERPINB5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/752 SNPs in SERPINB5 are shown (see all 752)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80977741,2
    C,F,H--61142199(+) AATCAC/TCCAAA 1 -- us2k135Minor allele frequency- T:0.28NS NA EA WA CSA 2974
    rs1399508661,2
    --61142345(+) CTCTAC/TCATTT 1 -- us2k10--------
    rs1140598721,2
    F--61142436(+) AATAAC/TATGCT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1493595941,2
    --61142516(+) AGGAAA/GCACAT 1 -- us2k10--------
    rs72443691,2
    C,F,A,H--61142647(+) TGAAGC/ATAAAG 1 -- us2k118Minor allele frequency- A:0.26NS EA NA WA CSA 771
    rs72439521,2
    C,F,H--61142736(+) ATTCTC/TATTTT 1 -- us2k15Minor allele frequency- T:0.04NS EA WA 530
    rs792497731,2
    F--61142957(+) AGTTGC/TTCTTA 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs1833630451,2
    --61142966(+) TATTCA/GTTACT 1 -- us2k10--------
    rs1446652441,2
    --61142978(+) AACAAA/GCACTT 1 -- us2k10--------
    rs1873500271,2
    --61143019(+) CCAAGA/CTTTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SERPINB5 (61143994 - 61172318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SERPINB5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv26779CNV Loss19812545
    nsv131597CNV Loss16902084


    Human Gene Mutation Database (HGMD): SERPINB5
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 154790    OMIM disorders: --

    20/60 diseases for SERPINB5 (see all 60):    About MalaCards
    gastric adenocarcinoma    pancreatic ductal adenocarcinoma    laryngeal carcinoma    cheilitis
    actinic cheilitis    mucoepidermoid carcinoma    adenoiditis    salivary gland cancer
    myoepithelioma    tongue cancer    bladder carcinoma    edwards syndrome
    adenoid cystic carcinoma    polymorphous low-grade adenocarcinoma    cholelithiasis    oral squamous cell carcinoma
    pleomorphic adenoma    gallbladder cancer    papillary thyroid carcinoma    thyroid cancer


    SERPINB5 for disorders           About GeneDecksing

    10/62 Novoseek inferred disease relationships for SERPINB5 gene (see all 62)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 68.6 137 17352241 (6), 18367129 (5), 12507299 (4), 16540429 (4) (see all 91)
    tumors 66.6 482 17396143 (8), 16799655 (7), 12011991 (7), 12425757 (6) (see all 99)
    breast cancer 63.8 155 12493023 (8), 16491398 (7), 11440731 (7), 12220518 (6) (see all 63)
    carcinoma 61.2 85 15009909 (5), 18236066 (5), 15608662 (4), 17936671 (4) (see all 39)
    myoepithelioma 60.9 2 12610349 (1), 11795829 (1)
    prostate cancer 57.7 77 12006534 (6), 18931702 (6), 19285254 (6), 17458898 (4) (see all 35)
    cancer 54.9 100 9299418 (3), 14991928 (3), 11309327 (2), 15872371 (2) (see all 63)
    breast carcinoma 53.6 12 9865722 (2), 12425757 (1), 12231537 (1), 17001697 (1) (see all 8)
    adenoma follicular 52.5 4 12964023 (1), 15009909 (1), 16892558 (1), 14532972 (1)
    adenocarcinoma 52 77 17396143 (7), 12969792 (4), 17536309 (4), 15197584 (4) (see all 26)

    Human Genome Epidemiology (HuGE) Navigator: SERPINB5 (2 documents)

    Export disorders for SERPINB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINB5 gene, integrated from 9 sources (see all 370):
    (articles sorted by number of sources associating them with SERPINB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. (PubMed id 8290962)1, 2, 3, 9 Zou Z.... Sager R. (1994)
    2. The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. (PubMed id 15760906)1, 2, 9 Law R.H.... Whisstock J.C. (2005)
    3. The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin. (PubMed id 7797587)1, 2, 9 Pemberton P.A.... Barr P.J. (1995)
    4. Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells. (PubMed id 16720730)1, 3, 9 Cella N....Zhang M. (2006)
    5. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PubMed id 7724531)1, 3, 9 Schneider S.S.... Silverman G.A. (1995)
    6. Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership. (PubMed id 16049006)1, 2 Bailey C.M....Hendrix M.J.C. (2005)
    7. The paradoxical expression of maspin in ovarian carcinoma. (PubMed id 12231537)1, 9 Sood A.K....Hendrix M.J. (2002)
    8. Maspin expression and its clinicopathological significance in tumorigenesis and progression of gastric cancer. (PubMed id 14991928)1, 9 Wang M.C....Li Y. (2004)
    9. Tamoxifen induces the expression of maspin through estrogen receptor-alpha. (PubMed id 15145521)1, 9 Liu Z....Zhang M. (2004)
    10. Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin. (PubMed id 11751384)1, 9 Biliran H. and Sheng S. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5268 HGNC: 8949 AceView: SERPINB5 Ensembl:ENSG00000206075 euGenes: HUgn5268
    ECgene: SERPINB5 Kegg: 5268 H-InvDB: SERPINB5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINB5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERPINB5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERPINB5 gene:
    Search GeneIP for patents involving SERPINB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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