Aliases for SERPINB4 Gene
External Ids for SERPINB4 Gene
Previous HGNC Symbols for SERPINB4 Gene
Previous GeneCards Identifiers for SERPINB4 Gene
The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]
GeneCards Summary for SERPINB4 Gene
SERPINB4 (Serpin Family B Member 4) is a Protein Coding gene. Diseases associated with SERPINB4 include Squamous Cell Carcinoma and Chromosome 18Q Deletion Syndrome. Among its related pathways are Amoebiasis. Gene Ontology (GO) annotations related to this gene include enzyme binding and protease binding. An important paralog of this gene is SERPINB3.
UniProtKB/Swiss-Prot for SERPINB4 Gene
May act as a protease inhibitor to modulate the host immune response against tumor cells.