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SERPINB4 Gene

protein-coding   GIFtS: 52
GCID: GC18M061277

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: SCCA2)
  See SERPINB4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 41 2     LEUPIN2
SCCA21 2 3 5     SCCA12
Squamous Cell Carcinoma Antigen 21 2 3     Protease Inhibitor (Leucine-Serpin)2
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 41 2     SCCA2/SCCA1 Fusion Protein2
Peptidase Inhibitor 112 3     Serpin B42
PI-112 3     Squamous Cell Carcinoma Antigen 12
PI112 3     Leupin3
SCCA-22 3     

External Ids:    HGNC: 105701   Entrez Gene: 63182   Ensembl: ENSG000002060737   OMIM: 6005185   UniProtKB: P485943   

Export aliases for SERPINB4 gene to outside databases

Previous GC identifers: GC18M061143 GC18M059456 GC18M059419 GC18M059458 GC18M059459 GC18M058004


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERPINB4 Gene:
SERPINB4 (serpin peptidase inhibitor, clade B (ovalbumin), member 4) is a protein-coding gene. Diseases associated with SERPINB4 include inverted papilloma, and burns. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: SPB4_HUMAN, P48594
Function: May act as a protease inhibitor to modulate the host immune response against tumor cells

Gene Wiki entry for SERPINB4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERPINB4 gene promoter:
         SRF   Pax-6   SRF (504 AA)   HNF-4alpha2   POU3F2   HNF-4alpha1   HEN1   HFH-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SERPINB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERPINB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.33

SERPINB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB4 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M061277:  view genomic region     (about GC identifiers)

Start:
61,304,493 bp from pter      End:
61,311,532 bp from pter
Size:
7,040 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPB4_HUMAN, P48594 (See protein sequence)
Recommended Name: Serpin B4  
Size: 390 amino acids; 44854 Da
Secondary accessions: A8K847

Explore the universe of human proteins at neXtProt for SERPINB4: NX_P48594

Explore proteomics data for SERPINB4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SERPINB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002965.1  
    ENSEMBL proteins: 
     ENSP00000343445   ENSP00000398645   ENSP00000399796   ENSP00000348795  

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    Search eBioscience for ELISAs for SERPINB4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Serpin_CS
     IPR000215 Serpin_fam
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry P48594

    ProtoNet protein and cluster: P48594

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: SPB4_HUMAN, P48594
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    Find genes that share domains with SERPINB4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPB4_HUMAN, P48594
    Function: May act as a protease inhibitor to modulate the host immune response against tumor cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity NAS7589435
         
    Find genes that share ontologies with SERPINB4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERPINB4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINB4
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPB4_HUMAN, P48594: Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol2
    nucleus2
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IBA--
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with SERPINB4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SERPINB4 About    
    See pathways by source

    SuperPathContained pathways About
    1Amoebiasis
    Amoebiasis


    Find genes that share SuperPaths with SERPINB4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for SERPINB4):
        Amoebiasis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERPINB4
    Interactions:

        GeneGlobe Interaction Network for SERPINB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SERPINB4 (P485943 ENSP000003434454) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2973, ENSP000003592064I2D: score=2 STRING: ENSP00000359206
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    CTSSP257743, ENSP000003579814I2D: score=1 STRING: ENSP00000357981
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    USF2Q158533, ENSP000002223054I2D: score=2 STRING: ENSP00000222305
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response ----
    GO:0010466negative regulation of peptidase activity IDA12949073
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis NAS7589435

    Find genes that share ontologies with SERPINB4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERPINB4 (SPB4)

    3 Novoseek inferred chemical compound relationships for SERPINB4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scca1 99.4 216 20527047 (9), 10956412 (8), 11267667 (8), 10653592 (7) (see all 47)
    serine 66.8 30 10653592 (2), 9548757 (2), 9811823 (2), 9817977 (2) (see all 17)
    cysteine 59.8 28 9811823 (4), 10852705 (4), 10653592 (2), 9548757 (1) (see all 14)



    Find genes that share compounds with SERPINB4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SERPINB4 gene: 
    NM_002974.2  

    Unigene Cluster for SERPINB4:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 4
    Hs.123035  [show with all ESTs]
    Unigene Representative Sequence: BC017401
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341074(uc002lje.3 uc002ljf.3 uc002ljg.3) ENST00000413673
    ENST00000436264 ENST00000498496 ENST00000356424
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SERPINB4
      QuantiFast Probe-based Assays in human, mouse, rat SERPINB4

    Additional mRNA sequence: 

    AB046400.1 AF461147.1 AK292212.1 AY245780.1 AY245782.1 BC008399.1 BC017401.1 U19557.1 
    X89015.1 

    6 DOTS entries:

    DT.92432754  DT.453388  DT.92432755  DT.97774794  DT.97811603  DT.100788918 

    Selected AceView cDNA sequences (see all 135):

    BE720615 BM975848 BU685771 AA861180 AI081890 BU674965 NM_006919 BX477537 
    BU676264 U19557 U19556 S66896 BU686141 BM968451 BQ028405 BM968440 
    BC008483 BM978687 AB046399 BU687165 AB046400 CB129418 BE156503 BC005224 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERPINB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SERPINB4 Expression
    About this image


    SERPINB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
    SERPINB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERPINB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.123035

    UniProtKB/Swiss-Prot: SPB4_HUMAN, P48594
    Tissue specificity: Squamous cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SERPINB4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpinb3c5
    Serpinb3a1
    serine (or cysteine) peptidase inhibitor, clade B, more5
    serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), more1
    71.68(n)1
    60.88(a)1
      1 (50.34 cM)5
    202481  NM_009126.31  NP_033152.31 
     1072712015 
    chicken
    (Gallus gallus)
    Aves OVALY1 ovalbumin-related protein Y (SERPINB14B) 56.88(n)
    45.71(a)
      420897  NM_001031001.1  NP_001026172.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    50(a)
    49(a)
    many ↔ many
    many ↔ many
    GL343311.1(566764-578510)
    GL343311.1(595295-637065)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004903141 serpin B4-like 55.07(n)
    43.3(a)
      100490314  XM_002936419.2  XP_002936465.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spn43
    Spn42Dd1
    serpin3
    Serpin 42Dd1
    37(a)
    (best of 15)3
    49.38(n)1
    39.6(a)1
      42D43
    498081  NM_001169596.31  NP_001163067.11 
    worm
    (Caenorhabditis elegans)
    Secernentea srp-73
    srp-51
    serine protease inhibitor3
    srp-51
    32(a)
    (best of 3)3
    49.09(n)1
    38.18(a)1
      V(8184025-8185481)3
    1919591  NM_072488.31  NP_504889.21 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SRP31 SRP3 47.47(n)
    37.15(a)
      842706  NM_105076.1  NP_176586.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g06107001 Os03g0610700 47.62(n)
    42.35(a)
      4333433  NM_001057186.1  NP_001050651.1 


    ENSEMBL Gene Tree for SERPINB4 (if available)
    TreeFam Gene Tree for SERPINB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERPINB4 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB32  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINB112  SERPINE32  
    SERPINB132  SERPINB82  
    Selected SIMAP similar genes for SERPINB4 using alignment to 6 protein entries:     SPB4_HUMAN (see all proteins) (see all similar genes):
    SCCA1    HUR 7    SCCA2    SERPINB3    SERPINB13    DKFZp686O07189
    PLANH2    SERPINB11    DKFZp686D06190    SERPINB10    SERPINB1    SERPINB7
    SERPINB12    SERPINB8    SERPINB6    HMSD    SERPINB9    SERPINB2

    Find genes that share paralogs with SERPINB4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERPINB4 (see all 300)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1401161711,2
    --61304021(+) ACAAGA/GTATTC 1 -- int10--------
    rs765183331,2
    --61304029(+) TTCTTC/GCATCC 1 -- int10--------
    rs1473375321,2
    --61304158(+) TTTATA/GTATGG 1 -- int10--------
    rs1908366771,2
    --61304162(+) TATATC/GGTAAC 1 -- int10--------
    rs43639411,2
    A,H--61304177(+) CTGTTC/GTTTCC 1 -- int14Minor allele frequency- G:0.00NS EA 416
    rs111523971,2
    C,F--61304185(+) TCCTCG/ACATCC 1 -- int13Minor allele frequency- A:0.20WA CSA 122
    rs1113304441,2
    F--61304246(+) TTTTAG/TGCCCC 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs1139662851,2
    F--61304248(+) TTATGC/ACCCTC 1 -- int12Minor allele frequency- A:0.50CSA 4
    rs1826110321,2
    --61304299(+) CCCTTC/TAGCAT 1 -- int10--------
    rs1410183521,2
    --61304394(+) GTTTTA/TAATTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SERPINB4 (61304493 - 61311532 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SERPINB4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717205CNV Deletion23290073
    esv2313855CNV Deletion18987734
    nsv833672CNV Gain17160897

    Human Gene Mutation Database (HGMD): SERPINB4
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600518    OMIM disorders: --

    5 diseases for SERPINB4:    
    About MalaCards
    inverted papilloma    burns    allergic asthma    idiopathic pulmonary fibrosis
    cervical cancer


    Find genes that share disorders with SERPINB4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SERPINB4 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 79.4 59 20527047 (5), 11267667 (3), 16006770 (2), 15192315 (2) (see all 27)
    squamous cell cancer 52.2 3 11241309 (1), 16710347 (1)
    cervical cancer 34.3 7 18497852 (2), 16641548 (2), 17291250 (1), 10873412 (1)
    tumors 23.5 16 12437110 (3), 12702576 (2), 10956412 (2), 10217177 (1) (see all 11)
    cancer 21.5 16 19125792 (3), 17016656 (2), 18097581 (2), 17549365 (1) (see all 7)
    asthma 12.7 3 14630915 (1), 16238792 (1)
    cancer lung 2.33 2 16710347 (1)
    necrosis 0 1 11722574 (1)
    adenocarcinoma 0 7 11267667 (3), 14647462 (1)
    metastasis 0 7 18097581 (3), 17016656 (1)

    Human Genome Epidemiology (HuGE) Navigator: SERPINB4 (1 document)

    Export disorders for SERPINB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERPINB4 gene, integrated from 10 sources (see all 91):
    (articles sorted by number of sources associating them with SERPINB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PubMed id 7724531)1, 2, 3, 9 Schneider S.S.... Silverman G.A. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    2. Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter. (PubMed id 11267667)1, 2, 9 Hamada K.... Ito M. (Biochim. Biophys. Acta 2001)
    3. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. (PubMed id 10956412)1, 2, 9 Uemura Y.... Silverman G.A. (Int. J. Cancer 2000)
    4. The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1. (PubMed id 14630915)1, 3, 9 Sakata Y....Izuhara K. (J. Biol. Chem. 2004)
    5. Identification of a novel human serpin gene; cloning sequencing and expression of leupin. (PubMed id 7589435)1, 2, 9 Barnes R.C. and Worrall D.M. (FEBS Lett. 1995)
    6. Update of the human and mouse SERPIN gene superfamily. (PubMed id 24172014)1, 3 Heit C....Vasiliou V. (Hum. Genomics 2013)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage. (PubMed id 10852705)1, 9 Luke C....Silverman G.A. (Biochemistry 2000)
    9. Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis. (PubMed id 12437110)1, 9 Takeda A....Hibino T. (Biol. Chem. 2002)
    10. Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. (PubMed id 10653592)1, 9 Cataltepe S....Upton M.P. (J. Histochem. Cytochem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6318 HGNC: 10570 AceView: SERPINB4andSERPINB3 Ensembl:ENSG00000206073 euGenes: HUgn6318
    ECgene: SERPINB4 Kegg: 6318 H-InvDB: SERPINB4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERPINB4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERPINB4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERPINB4 gene:
    Search GeneIP for patents involving SERPINB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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