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Aliases for SERPINB4 Gene

Aliases for SERPINB4 Gene

  • Serpin Family B Member 4 2 3 5
  • Squamous Cell Carcinoma Antigen 2 2 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 4 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 4 2 3
  • Peptidase Inhibitor 11 3 4
  • LEUPIN 3 4
  • SCCA-2 3 4
  • SCCA2 3 4
  • PI11 3 4
  • Protease Inhibitor (Leucine-Serpin) 3
  • Squamous Cell Carcinoma Antigen 1 3
  • SCCA2/SCCA1 Fusion Protein 3
  • Serpin B4 3
  • SCCA1 3
  • PI-11 4

External Ids for SERPINB4 Gene

Previous HGNC Symbols for SERPINB4 Gene

  • SCCA2

Previous GeneCards Identifiers for SERPINB4 Gene

  • GC18M061143
  • GC18M061277
  • GC18M059456
  • GC18M059419
  • GC18M059458
  • GC18M059459
  • GC18M058004

Summaries for SERPINB4 Gene

Entrez Gene Summary for SERPINB4 Gene

  • The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]

GeneCards Summary for SERPINB4 Gene

SERPINB4 (Serpin Family B Member 4) is a Protein Coding gene. Diseases associated with SERPINB4 include Squamous Cell Carcinoma and Chromosome 18Q Deletion Syndrome. Among its related pathways are Amoebiasis. Gene Ontology (GO) annotations related to this gene include enzyme binding and protease binding. An important paralog of this gene is SERPINB3.

UniProtKB/Swiss-Prot for SERPINB4 Gene

  • May act as a protease inhibitor to modulate the host immune response against tumor cells.

Gene Wiki entry for SERPINB4 Gene

Additional gene information for SERPINB4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB4 Gene

Genomics for SERPINB4 Gene

GeneHancer (GH) Regulatory Elements for SERPINB4 Gene

Promoters and enhancers for SERPINB4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I063644 Promoter 0.5 EPDnew 550.8 +0.0 43 0.1 SERPINB4 SERPINB13
GH18I063603 Enhancer 0.8 Ensembl ENCODE 0.3 +39.8 39842 2.6 USF1 JUNB BATF ATF2 IRF4 JUND ZFHX2 BCL11A SERPINB11 SERPINB13 SERPINB4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERPINB4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINB4 gene promoter:

Genomic Locations for SERPINB4 Gene

Genomic Locations for SERPINB4 Gene
7,061 bases
Minus strand

Genomic View for SERPINB4 Gene

Genes around SERPINB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB4 Gene

Proteins for SERPINB4 Gene

  • Protein details for SERPINB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serpin B4
    Protein Accession:
    Secondary Accessions:
    • A8K847

    Protein attributes for SERPINB4 Gene

    390 amino acids
    Molecular mass:
    44854 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERPINB4 Gene

Post-translational modifications for SERPINB4 Gene

No Post-translational modifications

Other Protein References for SERPINB4 Gene

No data available for DME Specific Peptides for SERPINB4 Gene

Domains & Families for SERPINB4 Gene

Gene Families for SERPINB4 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SERPINB4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serpin family. Ov-serpin subfamily.
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB4: view

Function for SERPINB4 Gene

Molecular function for SERPINB4 Gene

UniProtKB/Swiss-Prot Function:
May act as a protease inhibitor to modulate the host immune response against tumor cells.

Gene Ontology (GO) - Molecular Function for SERPINB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 21857942
GO:0004867 serine-type endopeptidase inhibitor activity NAS 7589435
GO:0019899 enzyme binding IPI 23382074
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB4: view

Phenotypes for SERPINB4 Gene

genes like me logo Genes that share phenotypes with SERPINB4: view

Animal Models for SERPINB4 Gene

MGI Knock Outs for SERPINB4:

Animal Model Products

CRISPR Products

miRNA for SERPINB4 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINB4 Gene

Localization for SERPINB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB4 Gene

Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB4 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
plasma membrane 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SERPINB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA,IBA --
GO:0005622 intracellular IDA 21857942
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with SERPINB4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINB4 Gene

Pathways & Interactions for SERPINB4 Gene

SuperPathways for SERPINB4 Gene

SuperPathway Contained pathways
1 Amoebiasis
genes like me logo Genes that share pathways with SERPINB4: view

Pathways by source for SERPINB4 Gene

1 KEGG pathway for SERPINB4 Gene

Gene Ontology (GO) - Biological Process for SERPINB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IDA,IEA 12949073
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0030162 regulation of proteolysis NAS 7589435
GO:0042270 protection from natural killer cell mediated cytotoxicity IMP 21857942
genes like me logo Genes that share ontologies with SERPINB4: view

No data available for SIGNOR curated interactions for SERPINB4 Gene

Drugs & Compounds for SERPINB4 Gene

(2) Drugs for SERPINB4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SERPINB4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB4: view

Transcripts for SERPINB4 Gene

Unigene Clusters for SERPINB4 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB4 Gene

No ASD Table

Relevant External Links for SERPINB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERPINB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB4 Gene

This gene is overexpressed in Vagina (x20.0), Esophagus - Mucosa (x13.4), Cervix - Ectocervix (x12.7), and Minor Salivary Gland (x5.2).

Protein differential expression in normal tissues from HIPED for SERPINB4 Gene

This gene is overexpressed in Cervix (24.7), Nasal epithelium (19.0), and Stomach (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINB4 Gene

Protein tissue co-expression partners for SERPINB4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERPINB4 Gene:


SOURCE GeneReport for Unigene cluster for SERPINB4 Gene:


mRNA Expression by UniProt/SwissProt for SERPINB4 Gene:

Tissue specificity: Squamous cells.

Evidence on tissue expression from TISSUES for SERPINB4 Gene

  • Bone marrow(4)
  • Skin(2.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with SERPINB4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB4 Gene

Orthologs for SERPINB4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERPINB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERPINB4 33
  • 98.03 (n)
(Canis familiaris)
Mammalia SERPINB4 33
  • 77.69 (n)
-- 34
  • 63 (a)
(Bos Taurus)
Mammalia LOC100337240 33
  • 75.32 (n)
-- 34
  • 68 (a)
-- 34
  • 66 (a)
  • 66 (a)
-- 34
  • 64 (a)
-- 34
  • 64 (a)
(Mus musculus)
Mammalia Serpinb3a 33 16 34
  • 71.68 (n)
Serpinb3d 34
  • 60 (a)
Serpinb3b 34
  • 59 (a)
Serpinb3c 34
  • 58 (a)
(Rattus norvegicus)
Mammalia Serpinb3a 33
  • 71.16 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
-- 34
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
(Gallus gallus)
Aves OVALY 33 34
  • 56.88 (n)
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 50 (a)
-- 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490314 33
  • 55.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta Spn42Dd 33
  • 49.38 (n)
Spn4 35
  • 37 (a)
Spn1 35
  • 36 (a)
CG9455 35
  • 34 (a)
serpin-27A 35
  • 34 (a)
Spn2 35
  • 34 (a)
Spn6 35
  • 34 (a)
CG9460 35
  • 33 (a)
Spn3 35
  • 33 (a)
Spn43Aa 35
  • 32 (a)
CG6717 35
  • 30 (a)
Spn5 35
  • 29 (a)
CG7722 35
  • 28 (a)
nec 35
  • 28 (a)
CG6687 35
  • 27 (a)
Spn43Ab 35
  • 27 (a)
(Caenorhabditis elegans)
Secernentea srp-5 33
  • 49.09 (n)
srp-7 35
  • 32 (a)
srp-1 35
  • 29 (a)
srp-6 35
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SRP3 33
  • 47.47 (n)
(Oryza sativa)
Liliopsida Os03g0610700 33
  • 47.62 (n)
Species where no ortholog for SERPINB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINB4 Gene

Gene Tree for SERPINB4 (if available)
Gene Tree for SERPINB4 (if available)

Paralogs for SERPINB4 Gene

Variants for SERPINB4 Gene

Sequence variations from dbSNP and Humsavar for SERPINB4 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs193921093 uncertain-significance, Malignant tumor of prostate 63,639,770(-) A/T coding_sequence_variant, missense_variant
rs1000251482 -- 63,640,185(-) G/C intron_variant
rs1000308317 -- 63,644,790(-) A/G upstream_transcript_variant
rs1000360039 -- 63,644,466(-) A/G upstream_transcript_variant
rs1000643908 -- 63,643,526(-) G/A coding_sequence_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for SERPINB4 Gene

Variant ID Type Subtype PubMed ID
dgv621e214 CNV loss 21293372
dgv994e212 CNV loss 25503493
esv2313855 CNV deletion 18987734
esv2717205 CNV deletion 23290073
esv3642777 CNV loss 21293372
esv3642778 CNV loss 21293372
esv3642779 CNV gain 21293372
nsv1066552 CNV gain 25217958
nsv833672 CNV gain 17160897
nsv978638 CNV duplication 23825009

Variation tolerance for SERPINB4 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINB4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB4 Gene

Disorders for SERPINB4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SERPINB4 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
squamous cell carcinoma
  • epidermoid carcinoma
chromosome 18q deletion syndrome
  • chromosome 18q- syndrome
lubs x-linked mental retardation syndrome
  • mrxsl
cervical cancer
  • cervical cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERPINB4

genes like me logo Genes that share disorders with SERPINB4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB4 Gene

Publications for SERPINB4 Gene

  1. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PMID: 7724531) Schneider SS … Silverman GA (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 22 58
  2. The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1. (PMID: 14630915) Sakata Y … Izuhara K (The Journal of biological chemistry 2004) 2 3 22 58
  3. Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter. (PMID: 11267667) Hamada K … Ito M (Biochimica et biophysica acta 2001) 3 4 22 58
  4. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. (PMID: 10956412) Uemura Y … Silverman GA (International journal of cancer 2000) 3 4 22 58
  5. Identification of a novel human serpin gene; cloning sequencing and expression of leupin. (PMID: 7589435) Barnes RC … Worrall DM (FEBS letters 1995) 3 4 22 58

Products for SERPINB4 Gene

Sources for SERPINB4 Gene

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