Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINB4 Gene

protein-coding   GIFtS: 52
GCID: GC18M061277

serpin peptidase inhibitor, clade B (ovalbumin), member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: SCCA2)
 Explore 20 diseases affiliated with
SERPINB4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SERPINB4    

Aliases
for SERPINB4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 41 2     Squamous Cell Carcinoma Antigen 22 3
SCCA21 2 3 5     PI-112 3
PI111 2 3     Protease Inhibitor (Leucine-Serpin)2
SCCA-21 2 3     SCCA2/SCCA1 Fusion Protein2
LEUPIN1 2     Serpin B42
SCCA11 2     Squamous Cell Carcinoma Antigen 12
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 41 2     Leupin3
Peptidase Inhibitor 112 3     

External Ids:    HGNC: 105701   Entrez Gene: 63182   Ensembl: ENSG000002060737   OMIM: 6005185   UniProtKB: P485943   

Export aliases for SERPINB4 gene to outside databases

Previous GC identifers: GC18M061143 GC18M059456 GC18M059419 GC18M059458 GC18M059459 GC18M058004


Summaries
for SERPINB4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SPB4_HUMAN, P48594
Function: May act as a protease inhibitor to modulate the host immune response against tumor cells

Gene Wiki entry for SERPINB4


Genomic Views
for SERPINB4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINB4 gene promoter:
         SRF   Pax-6   SRF (504 AA)   HNF-4alpha2   POU3F2   HNF-4alpha1   HEN1   HFH-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SERPINB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.33

SERPINB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB4 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M061277:  view genomic region     (about GC identifiers)

Start:
 61,304,493 bp from pter      End:
 61,311,532 bp from pter
Size:
 7,040 bases      Orientation:
 minus strand

Proteins
for SERPINB4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPB4_HUMAN, P48594 (See protein sequence)
Recommended Name: Serpin B4  
Size: 390 amino acids; 44854 Da
Subcellular location: Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level

Explore the universe of human proteins at neXtProt for SERPINB4: NX_P48594

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48594

    • SERPINB4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002965.1  
    ENSEMBL proteins: 
     ENSP00000343445   ENSP00000398645   ENSP00000399796   ENSP00000348795  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SERPINB4
    OriGene Protein Over-expression Lysate: SERPINB4
    OriGene Custom Protein Services for SERPINB4 
    GenScript Custom Purified and Recombinant Proteins Services for SERPINB4
    Novus Biologicals SERPINB4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SERPINB4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IBA--
    GO:0005737cytoplasm NAS--


    SERPINB4 for ontologies           About GeneDecksing



    SERPINB4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 8): SERPINB4
    OriGene Custom Antibody Services for SERPINB4 
    GenScript Custom Superior Antibodies Services for SERPINB4
    Novus Biologicals SERPINB4 Antibodies
    Search for Antibodies for SERPINB4 at Abcam  
    Uscn Antibodies for SERPINB4
    Search ThermoFisher Antibodies for SERPINB4

    Assay Products for SERPINB4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SERPINB4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SERPINB4

    Protein Domains /
    Families
    for SERPINB4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SERPINB4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P48594

    ProtoNet protein and cluster: P48594

    1 Blocks protein family: IPB000215 Serpin

    UniProtKB/Swiss-Prot: SPB4_HUMAN, P48594
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    Function
    for SERPINB4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPB4_HUMAN, P48594
    Function: May act as a protease inhibitor to modulate the host immune response against tumor cells

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SERPINB4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SERPINB4
    SwitchGear 3'UTR luciferase reporter plasmid: SERPINB4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB4 (see all 4)
    OriGene shRNA RFP: SERPINB4
    OriGene siRNA: SERPINB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SERPINB4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB4 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB4 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SERPINB4 (NM_002974)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SERPINB4
    Search LifeMap BioReagents cell lines for SERPINB4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB4

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity NAS7589435


    SERPINB4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SERPINB4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amoebiasis
    		Amoebiasis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for SERPINB4):
        Amoebiasis


    SERPINB4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/11 Interacting proteins for SERPINB4 (P485943 ENSP000003434454) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2973, ENSP000003592064I2D: score=2 STRING: ENSP00000359206
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    CTSSP257743, ENSP000003579814I2D: score=1 STRING: ENSP00000357981
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    USF2Q158533, ENSP000002223054I2D: score=2 STRING: ENSP00000222305
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS--
    GO:0010466negative regulation of peptidase activity IDA12949073
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis NAS7589435


    SERPINB4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SERPINB4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINB4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINB4
    3 Novoseek chemical compound relationships for SERPINB4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scca1 99.4 216 20527047 (9), 10956412 (8), 11267667 (8), 10653592 (7) (see all 47)
    serine 66.8 30 10653592 (2), 9548757 (2), 9811823 (2), 9817977 (2) (see all 17)
    cysteine 59.8 28 9811823 (4), 10852705 (4), 10653592 (2), 9548757 (1) (see all 14)

    Search CenterWatch for drugs/clinical trials and news about SERPINB4 / SPB4 

    Transcripts
    for SERPINB4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SERPINB4 gene: 
    NM_002974.2  

    Unigene Cluster for SERPINB4:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 4
    Hs.123035  [show with all ESTs]
    Unigene Representative Sequence: BC017401
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341074(uc002lje.3 uc002ljf.3 uc002ljg.3) ENST00000413673
    ENST00000436264 ENST00000498496 ENST00000356424

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SERPINB4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SERPINB4
    SwitchGear 3'UTR luciferase reporter plasmid: SERPINB4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB4 (see all 4)
    OriGene shRNA RFP: SERPINB4
    OriGene siRNA: SERPINB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB4 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB4 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SERPINB4 (NM_002974)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERPINB4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB4

    Additional cDNA sequence: 

    AB046400.1 AF461147.1 AK292212.1 AY245780.1 AY245782.1 BC008399.1 BC017401.1 U19557.1 
    X89015.1 

    6 DOTS entries:

    DT.92432754  DT.453388  DT.92432755  DT.97811603  DT.97774794  DT.100788918 

    24/135 AceView cDNA sequences (see all 135):

    BC008483 U19557 BT006748 BC005224 U19556 BU685771 AI081890 BU687165 
    BM978687 BE720615 AB046399 BM968440 NM_006919 CB129418 BU676264 BX477537 
    BU686141 AB046400 S66896 BE156503 BQ028405 BU674965 BM968451 AA398883 

    GeneLoc Exon Structure


    Expression
    for SERPINB4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SERPINB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINB4

    SOURCE GeneReport for Unigene cluster: Hs.123035

    UniProtKB/Swiss-Prot: SPB4_HUMAN, P48594
    Tissue specificity: Squamous cells

        SABiosciences Custom PCR Arrays for SERPINB4
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERPINB4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB4

    Orthologs
    for SERPINB4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SERPINB4 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SERPINB14B1 serpin peptidase inhibitor, clade B (ovalbumin), member more 56.45(n)
    45.45(a)    		   420897  NM_001031001.1  NP_001026172.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 50(a)
    50(a)
    		 many ↔ many
    many ↔ many
    		 GL343311.1(570280-578337)
    GL343311.1(623565-636049)
    zebrafish
    (Danio rerio)    		 Actinopterygii serpinb1l16
    zgc:1737296
    (see all 5)    		 zgc:173729
    (see all 5)    		 49(a)
    45(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 16(54874440-54879870)
    16(54858268-54864487)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Spn43
    Spn11    		 serpin3
    Serine protease inhibitor 11    		 37(a)
    (best of 15)3
    49.38(n)1
    39.6(a)1    		   42D43
    498081  NM_001169596.21  NP_001163067.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea srp-73
    srp-51    		 serine protease inhibitor3
    Protein SRP-51    		 32(a)
    (best of 3)3
    48.79(n)1
    38.18(a)1    		   V(8184025-8185481)3
    1919591  NM_072488.21  NP_504889.21 


    ENSEMBL Gene Tree for SERPINB4 (if available)
    TreeFam Gene Tree for SERPINB4 (if available) 

    Paralogs
    for SERPINB4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINB4 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB32  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINE32  SERPINB132  
    SERPINB82  
    18/39 SIMAP similar genes for SERPINB4 using alignment to 6 protein entries:     SPB4_HUMAN (see all proteins) (see all similar genes):
    SCCA1    HUR 7    SCCA2    SERPINB3    SERPINB13    DKFZp686O07189
    PLANH2    SERPINB11    DKFZp686D06190    SERPINB10    SERPINB1    SERPINB7
    SERPINB12    SERPINB8    SERPINB6    HMSD    SERPINB9    SERPINB2

    SERPINB4 for paralogs           About GeneDecksing



    Genomic Variants
    for SERPINB4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/227 NCBI SNPs in SERPINB4 are shown (see all 227)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1401161711,2
    		--61304021(+) ACAAGA/GTATTC 1 -- int10--------
    rs765183331,2
    		--61304029(+) TTCTTC/GCATCC 1 -- int10--------
    rs1473375321,2
    		--61304158(+) TTTATA/GTATGG 1 -- int10--------
    rs1908366771,2
    		--61304162(+) TATATC/GGTAAC 1 -- int10--------
    rs43639411,2
    		A,H--61304177(+) CTGTTC/GTTTCC 1 -- int14Minor allele frequency- G:0.00NS EA 416
    rs111523971,2
    		C,F,,--61304185(+) TCCTCG/ACATCC 1 -- int13Minor allele frequency- A:0.20WA CSA 122
    rs1113304441,2
    		F--61304246(+) TTTTAG/TGCCCC 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs1139662851,2
    		F--61304248(+) TTATGC/ACCCTC 1 -- int12Minor allele frequency- A:0.50CSA 4
    rs1826110321,2
    		--61304299(+) CCCTTC/TAGCAT 1 -- int10--------
    rs1410183521,2
    		--61304394(+) GTTTTA/TAATTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SERPINB4 (61304493 - 61311532 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SERPINB4
         2 CNVs: 43971 5059

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINB4
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINB4

    Disorders / Diseases
    for SERPINB4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SERPINB4 for disorders           About GeneDecksing

    OMIM gene information: 600518    OMIM disorders: --

    20 diseases for SERPINB4:    About MalaCards
    squamous cell carcinoma    carcinoma    ovarian sex cord tumors    oral squamous cell carcinoma
    cervical squamous cell carcinoma    bronchial asthma    atopic dermatitis    allergic asthma
    asthma    cervical cancer    cervicitis    dermatitis
    adenoiditis    hepatitis b    sinusitis    hepatocellular carcinoma
    lung cancer    breast cancer    hepatitis    esophagitis

    10/11 Novoseek disease relationships for SERPINB4 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 79.4 59 20527047 (5), 11267667 (3), 16006770 (2), 15192315 (2) (see all 27)
    squamous cell cancer 52.2 3 11241309 (1), 16710347 (1)
    cervical cancer 34.3 7 18497852 (2), 16641548 (2), 17291250 (1), 10873412 (1)
    tumors 23.5 16 12437110 (3), 12702576 (2), 10956412 (2), 10217177 (1) (see all 11)
    cancer 21.5 16 19125792 (3), 17016656 (2), 18097581 (2), 17549365 (1) (see all 7)
    asthma 12.7 3 14630915 (1), 16238792 (1)
    cancer lung 2.33 2 16710347 (1)
    necrosis 0 1 11722574 (1)
    adenocarcinoma 0 7 11267667 (3), 14647462 (1)
    metastasis 0 7 18097581 (3), 17016656 (1)

    Human Genome Epidemiology (HuGE) Navigator: SERPINB4 (1 document)

    Export disorders for SERPINB4 gene to outside databases

    Publications
    for SERPINB4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINB4 gene, integrated from 9 sources (see all 85):
    (articles sorted by number of sources associating them with SERPINB4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PubMed id 7724531)1, 2, 3, 9 Schneider S.S.... Silverman G.A. (1995)
    2. Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter. (PubMed id 11267667)1, 2, 9 Hamada K.... Ito M. (2001)
    3. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. (PubMed id 10956412)1, 2, 9 Uemura Y.... Silverman G.A. (2000)
    4. The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1. (PubMed id 14630915)1, 3, 9 Sakata Y....Izuhara K. (2004)
    5. Identification of a novel human serpin gene; cloning sequencing and expression of leupin. (PubMed id 7589435)1, 2, 9 Barnes R.C. and Worrall D.M. (1995)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage. (PubMed id 10852705)1, 9 Luke C....Silverman G.A. (2000)
    8. Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis. (PubMed id 12437110)1, 9 Takeda A....Hibino T. (2002)
    9. Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. (PubMed id 10653592)1, 9 Cataltepe S....Upton M.P. (2000)
    10. A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases. (PubMed id 9828132)1, 9 Bartuski A.J....Silverman G.A. (1998)

    External Searches for SERPINB4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SERPINB4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6318 HGNC: 10570 AceView: SERPINB4andSERPINB3 Ensembl:ENSG00000206073 euGenes: HUgn6318
    ECgene: SERPINB4 Kegg: 6318 H-InvDB: SERPINB4

    Other Databases showing SERPINB4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SERPINB4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINB4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERPINB4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SERPINB4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SERPINB4 gene:
    Search GeneIP for patents involving SERPINB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SERPINB4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for SERPINB4   OriGene shRNA RFP for SERPINB4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB4  
     OriGene Protein Over-expression Lysate for SERPINB4   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SERPINB4   OriGene 3'-UTR Clone for SERPINB4  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SERPINB4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SERPINB4   OriGene Custom Protein Services for SERPINB4  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERPINB4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINB4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB4
     GenScript Custom Purified and Recombinant Proteins Services for SERPINB4 GenScript cDNA clones with any tag delivered in your preferred vector for SERPINB4
     GenScript Custom Assay Services for SERPINB4 GenScript Custom Superior Antibodies Services for SERPINB4
     GenScript Custom overexpressing Cell Line Services for SERPINB4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SERPINB4 promoter
     Search Chromatin IP Primers for SERPINB4
     RT2 qPCR Primer Assay in human, mouse, rat SERPINB4
     GNC Network for SERPINB4
     SABiosciences Custom PCR Arrays for SERPINB4
     Search Tocris compounds for SERPINB4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SERPINB4 antibodies
     SERPINB4 lysates
     Search for Antibodies for SERPINB4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SERPINB4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SERPINB4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SERPINB4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB4
     SwitchGear 3'UTR luciferase reporter plasmids for SERPINB4
     Browse SwitchGear Promoter luciferase reporter plasmids for SERPINB4
     Search ThermoFisher Antibodies for SERPINB4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB4
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SERPINB4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4