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Aliases for SERPINB3 Gene

Aliases for SERPINB3 Gene

  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 2 3
  • SCCA1 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 3 2 3
  • Squamous Cell Carcinoma Antigen 1 3 4
  • Protein T4-A 3 4
  • SCCA-1 3 4
  • Serpin B3 3
  • HsT1196 3
  • SCCA-PD 3
  • T4-A 3
  • SCCA 4
  • SCC 3

External Ids for SERPINB3 Gene

Previous HGNC Symbols for SERPINB3 Gene

  • SCC
  • SCCA1

Previous GeneCards Identifiers for SERPINB3 Gene

  • GC18M061161
  • GC18M061295
  • GC18M059455
  • GC18M059457
  • GC18M059473
  • GC18M058022
  • GC18M061322

Summaries for SERPINB3 Gene

GeneCards Summary for SERPINB3 Gene

SERPINB3 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3) is a Protein Coding gene. Diseases associated with SERPINB3 include cervical squamous cell carcinoma and oral cancer. Among its related pathways are Amoebiasis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and virus receptor activity. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB3 Gene

  • May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).

Gene Wiki entry for SERPINB3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB3 Gene

Genomics for SERPINB3 Gene

Regulatory Elements for SERPINB3 Gene

Genomic Location for SERPINB3 Gene

Start:
63,637,719 bp from pter
End:
63,661,963 bp from pter
Size:
24,245 bases
Orientation:
Minus strand

Genomic View for SERPINB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB3 Gene

Proteins for SERPINB3 Gene

  • Protein details for SERPINB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29508-SPB3_HUMAN
    Recommended name:
    Serpin B3
    Protein Accession:
    P29508
    Secondary Accessions:
    • A6NDM2
    • B2RBT5
    • B3W5Y6
    • Q53H28
    • Q53YB5
    • Q86VF3
    • Q86W04
    • Q8IWL4
    • Q8IXI3
    • Q96J21
    • Q9BYF8

    Protein attributes for SERPINB3 Gene

    Size:
    390 amino acids
    Molecular mass:
    44565 Da
    Quaternary structure:
    • Interacts with MAPK8/JNK1.
    SequenceCaution:
    • Sequence=AAO11731.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SERPINB3 Gene

    Alternative splice isoforms for SERPINB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB3 Gene

Proteomics data for SERPINB3 Gene at MOPED

Post-translational modifications for SERPINB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINB3 Gene

Domains for SERPINB3 Gene

Gene Families for SERPINB3 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINB3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINB3 Gene

Graphical View of Domain Structure for InterPro Entry

P29508

UniProtKB/Swiss-Prot:

SPB3_HUMAN :
  • P29508
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB3: view

Function for SERPINB3 Gene

Molecular function for SERPINB3 Gene

UniProtKB/Swiss-Prot Function: May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).
UniProtKB/Swiss-Prot Induction: Strongly up-regulated in the upper epidermis of sun-exposed skin.

Gene Ontology (GO) - Molecular Function for SERPINB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IDA 12975381
GO:0002020 protease binding IPI 21383048
GO:0004867 serine-type endopeptidase inhibitor activity NAS 7724531
GO:0004869 cysteine-type endopeptidase inhibitor activity IMP 21383048
genes like me logo Genes that share ontologies with SERPINB3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINB3 Gene

Localization for SERPINB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB3 Gene

Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB3 Gene COMPARTMENTS Subcellular localization image for SERPINB3 gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 3
golgi apparatus 2
nucleus 2
chloroplast 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SERPINB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IBA --
GO:0005634 nucleus IDA 20527027
GO:0005737 cytoplasm IDA 20527027
GO:0031410 cytoplasmic vesicle IDA 21383048
genes like me logo Genes that share ontologies with SERPINB3: view

Pathways for SERPINB3 Gene

SuperPathways for SERPINB3 Gene

Superpath Contained pathways
1 Amoebiasis
genes like me logo Genes that share pathways with SERPINB3: view

Pathways by source for SERPINB3 Gene

1 KEGG pathway for SERPINB3 Gene

Gene Ontology (GO) - Biological Process for SERPINB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 20527027
GO:0009615 response to virus --
GO:0010466 negative regulation of peptidase activity IDA 12949073
GO:0010718 positive regulation of epithelial to mesenchymal transition IMP 20527027
GO:0010950 positive regulation of endopeptidase activity IDA 20527027
genes like me logo Genes that share ontologies with SERPINB3: view

Compounds for SERPINB3 Gene

(2) Drugbank Compounds for SERPINB3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
D-Serine
312-84-5 target
Phosphonoserine
target

(3) Novoseek inferred chemical compound relationships for SERPINB3 Gene

Compound -log(P) Hits PubMed IDs
scca1 99.3 167
serine 66 23
cysteine 54.4 18
genes like me logo Genes that share compounds with SERPINB3: view

Transcripts for SERPINB3 Gene

mRNA/cDNA for SERPINB3 Gene

Unigene Clusters for SERPINB3 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: -
SP2: - -
SP3: - - - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - -
SP6:
SP7:
SP8:
SP9: - - -

Relevant External Links for SERPINB3 Gene

GeneLoc Exon Structure for
SERPINB3
ECgene alternative splicing isoforms for
SERPINB3

Expression for SERPINB3 Gene

mRNA expression in normal human tissues for SERPINB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB3 Gene

This gene is overexpressed in Vagina (18.3), Esophagus - Mucosa (17.9), and Cervix - Ectocervix (12.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINB3 Gene

SOURCE GeneReport for Unigene cluster for SERPINB3 Gene Hs.227948

mRNA Expression by UniProt/SwissProt for SERPINB3 Gene

P29508-SPB3_HUMAN
Tissue specificity: Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).
genes like me logo Genes that share expressions with SERPINB3: view

Orthologs for SERPINB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB3 35
  • 97.95 (n)
  • 96.67 (a)
SERPINB3 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
SERPINB4 36
  • 67 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Serpinb3a 36
  • 60 (a)
ManyToMany
Serpinb3b 36
  • 58 (a)
ManyToMany
Serpinb3c 36
  • 56 (a)
ManyToMany
Serpinb3d 35
  • 71.5 (n)
  • 60.1 (a)
Serpinb3d 16
Serpinb3d 36
  • 59 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves OVALY 36
  • 45 (a)
ManyToMany
SERPINB14 36
  • 39 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Spn43Ab 37
  • 26 (a)
serpin-27A 37
  • 34 (a)
Spn5 37
  • 28 (a)
Spn3 37
  • 33 (a)
Spn2 37
  • 32 (a)
Spn43Aa 37
  • 31 (a)
CG9455 37
  • 33 (a)
CG9460 37
  • 33 (a)
CG6687 37
  • 27 (a)
Spn1 37
  • 36 (a)
nec 37
  • 27 (a)
CG6717 37
  • 29 (a)
Spn6 37
  • 33 (a)
CG7722 37
  • 27 (a)
Spn4 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea srp-7 37
  • 31 (a)
srp-1 37
  • 29 (a)
srp-6 37
  • 29 (a)
Species with no ortholog for SERPINB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINB3 Gene

ENSEMBL:
Gene Tree for SERPINB3 (if available)
TreeFam:
Gene Tree for SERPINB3 (if available)

Paralogs for SERPINB3 Gene

genes like me logo Genes that share paralogs with SERPINB3: view

Variants for SERPINB3 Gene

Sequence variations from dbSNP and Humsavar for SERPINB3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs925 -- 63,655,534(-) ATGAT(A/C)GTCAT utr-variant-3-prime
rs470750 -- 63,661,943(-) AGGGA(A/G)AGGCA utr-variant-5-prime
rs601777 -- 63,655,210(-) AAATA(A/G)TGACA utr-variant-3-prime
rs601862 -- 63,655,165(-) AAGGG(A/C)AAGTG downstream-variant-500B
rs601888 -- 63,655,147(-) ACACA(C/T)AGGAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SERPINB3 Gene

Variant ID Type Subtype PubMed ID
nsv833672 CNV Gain 17160897
esv2717205 CNV Deletion 23290073

Relevant External Links for SERPINB3 Gene

HapMap Linkage Disequilibrium report
SERPINB3
Human Gene Mutation Database (HGMD)
SERPINB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB3 Gene

Disorders for SERPINB3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for SERPINB3 Gene including...

Search for SERPINB3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for SERPINB3 Gene

(25) Novoseek inferred disease relationships for SERPINB3 Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 84 89
cervical squamous cell carcinoma 65 4
hepatocellular carcinoma 55.1 6
squamous cell cancer 46.5 1
cirrhosis 40.7 2

Relevant External Links for SERPINB3

Genetic Association Database (GAD)
SERPINB3
Human Genome Epidemiology (HuGE) Navigator
SERPINB3
genes like me logo Genes that share disorders with SERPINB3: view

No data available for UniProtKB/Swiss-Prot for SERPINB3 Gene

Publications for SERPINB3 Gene

  1. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PMID: 7724531) Schneider S.S. … Silverman G.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23
  2. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. (PMID: 10956412) Uemura Y. … Silverman G.A. (Int. J. Cancer 2000) 3 4 23
  3. Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. (PMID: 14970861) Pontisso P. … Fassina G. (Br. J. Cancer 2004) 3 4 23
  4. Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease. (PMID: 18657489) Turato C. … Pontisso P. (Dig Liver Dis 2009) 3 23 48
  5. Humoral autoimmune responses to the squamous cell carcinoma antigen protein family in psoriasis. (PMID: 18385761) El-Rachkidy R.G. … Camp R.D. (J. Invest. Dermatol. 2008) 3 23

Products for SERPINB3 Gene

Sources for SERPINB3 Gene

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