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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINB3 Gene

protein-coding   GIFtS: 61
GCID: GC18M061295

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbols: SCC, SCCA1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 31 2     SCCA-12 3
SCCA11 2 3 5     HsT11962
SCC1 2     SCCA-PD2
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 31 2     T4-A2
Protein T4-A2 3     Serpin B32
Squamous Cell Carcinoma Antigen 12 3     SCCA3

External Ids:    HGNC: 105691   Entrez Gene: 63172   Ensembl: ENSG000000571497   OMIM: 6005175   UniProtKB: P295083   

Export aliases for SERPINB3 gene to outside databases

Previous GC identifers: GC18M061161 GC18M059455 GC18M059457 GC18M059473 GC18M058022


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SERPINB3 Gene: 
SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3) is a protein-coding gene. Diseases associated with SERPINB3 include cervical squamous cell carcinoma, and squamous cell carcinoma. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and virus receptor activity. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508
Function: May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor
cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun
NH(2)-terminal kinase (JNK1)

Gene Wiki entry for SERPINB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_025028.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINB3 gene promoter:
         SRF   Pax-6   SRF (504 AA)   HNF-4alpha2   Ik-3   POU3F2   HNF-4alpha1   AREB6   HFH-1   Sox9   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.3

SERPINB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB3 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M061295:  view genomic region     (about GC identifiers)

Start:
61,322,431 bp from pter      End:
61,329,197 bp from pter
Size:
6,767 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508 (See protein sequence)
Recommended Name: Serpin B3  
Size: 390 amino acids; 44565 Da
Subunit: Interacts with MAPK8/JNK1
Subcellular location: Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level
Developmental stage: Its expression is closely related to cellular differentiation in both normal and malignant
squamous cells
Sequence caution: Sequence=AAO11731.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SERPINB3:
2ZV6 (3D)    
Secondary accessions: A6NDM2 B2RBT5 B3W5Y6 Q53H28 Q53YB5 Q86VF3 Q86W04 Q8IWL4 Q8IXI3 Q96J21
Q9BYF8
Alternative splicing: 2 isoforms:  P29508-1   P29508-2   

Explore the universe of human proteins at neXtProt for SERPINB3: NX_P29508

Explore proteomics data for SERPINB3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P29508

  • SERPINB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERPINB3 Protein Expression
    REFSEQ proteins: NP_008850.1  
    ENSEMBL proteins: 
     ENSP00000283752   ENSP00000329498  

    Human Recombinant Protein Products for SERPINB3: 
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    Sino Biological Recombinant Protein for SERPINB3
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IBA--
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA--

    SERPINB3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P29508

    ProtoNet protein and cluster: P29508

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    SERPINB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPB3_HUMAN, P29508
    Function: May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor
    cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun
    NH(2)-terminal kinase (JNK1)
    Induction: Strongly up-regulated in the upper epidermis of sun-exposed skin

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IDA12975381
    GO:0004867serine-type endopeptidase inhibitor activity NAS7724531
         
    SERPINB3 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SERPINB3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Amoebiasis
    Amoebiasis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for SERPINB3):
        Amoebiasis


    SERPINB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/12 Interacting proteins for SERPINB3 (P295082, 3 ENSP000002837524) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF1BP203332, 3MINT-49424 I2D: score=2 
    CTSKP432353, ENSP000002716514I2D: score=2 STRING: ENSP00000271651
    CTSLP077113, ENSP000003453444I2D: score=2 STRING: ENSP00000345344
    CTSSP257743, ENSP000003579814I2D: score=2 STRING: ENSP00000357981
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615response to virus IDA12975381
    GO:0010466negative regulation of peptidase activity IDA12949073
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--
    GO:0043086negative regulation of catalytic activity IDA10956412

    SERPINB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINB3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINB3 (SPB3)

    2 DrugBank Compounds for SERPINB3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    D-Serine-- 312-84-5target--10592235
    Phosphonoserine-- --target--10592235

    3 Novoseek inferred chemical compound relationships for SERPINB3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scca1 99.3 245 20089382 (12), 12949073 (8), 10653592 (7), 14630915 (7) (see all 50)
    serine 66 27 10653592 (2), 9817977 (2), 9008232 (1), 20527027 (1) (see all 21)
    cysteine 54.4 20 10852705 (4), 10653592 (2), 9548757 (2), 14630915 (1) (see all 13)

    Search CenterWatch for drugs/clinical trials and news about SERPINB3 / SPB3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERPINB3 gene: 
    NM_006919.2  

    Unigene Cluster for SERPINB3:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 3
    Hs.227948  [show with all ESTs]
    Unigene Representative Sequence: NM_006919
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283752(uc002lji.3 uc010dqa.3 uc010dqb.3 uc010dqc.2)
    ENST00000332821
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB046399.1 AF428135.1 AF428136.1 AF428137.1 AF428138.1 AF428139.1 AF461146.1 AJ515706.1 
    AK222746.1 AK222753.1 AK307261.1 AK308383.1 AK310948.1 AK314805.1 AY190327.1 AY245778.1 
    AY245781.1 BC005224.1 BC008483.1 BT006748.1 EU852041.1 S66896.1 U19556.1 

    5 DOTS entries:

    DT.453388  DT.100788918  DT.92432754  DT.97774794  DT.97811603 

    24/135 AceView cDNA sequences (see all 135):

    AB046399 S66896 X89015 AI081890 BT006748 BM975848 BU685771 BU686141 
    BQ028405 BE720615 BC005224 BC008483 AA398883 BU674965 U19557 BX477537 
    CB129418 BM978687 BM968451 U19556 BU676264 BE156503 AB046400 BU687165 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB3 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
    SP1:                                                                                            -                                 
    SP2:                    -           -                                                                                             
    SP3:                    -           -     -     -     -     -     -     -     -     -     -     -     -     -                     
    SP4:                    -                                                                                                         
    SP5:                    -     -     -     -     -     -     -     -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for SERPINB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINB3 expression in normal human tissues (normalized intensities)      SERPINB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SERPINB3 Expression
    About this image


    SERPINB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Lung (Respiratory System)
             Trachea   
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
     
     Epithelium (Endocrine System)
             Human Prostate Epithelial Cells (HPrEpiC)   
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   
     
     Prostate (Endocrine System)
             Human Prostate Epithelial Cells (HPrEpiC)   

    See SERPINB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINB3

    SOURCE GeneReport for Unigene cluster: Hs.227948

    UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508
    Tissue specificity: Squamous cells. Expressed in some hepatocellular carcinoma (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINB3 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpinb3d1 , 5 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), more1, 5 71.5(n)1
    60.1(a)1
      1 (50.34 cM)5
    3942521  NM_201376.11  NP_958764.11 
     1070781935 
    chicken
    (Gallus gallus)
    Aves SERPINB66
    serpin B6
    51(a)
    possible ortholog
    2(67719974-67729598)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    48(a)
    48(a)
    (see all 3)
    many ↔ many
    possible ortholog
    (see all 3)
    GL343311.1(566764-578510)
    GL343311.1(703856-715609)
    zebrafish
    (Danio rerio)
    Actinopterygii serpinb1l16
    serpinb16
    (see all 7)
    serpin peptidase inhibitor, clade B (ovalbumin), m...
    serpin peptidase inhibitor, clade B (ovalbumin), m...
    (see all 7)
    49(a)
    47(a)
    (see all 7)
    possible ortholog
    many ↔ many
    (see all 7)
    16(54874440-54879870)
    20(26910467-26916434)


    ENSEMBL Gene Tree for SERPINB3 (if available)
    TreeFam Gene Tree for SERPINB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINB3 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINB112  SERPINE32  
    SERPINB132  SERPINB82  
    18/33 SIMAP similar genes for SERPINB3 using alignment to 1 protein entry:     SPB3_HUMAN(see all similar genes):
    SCCA2    SERPINB4    SERPINB13    SERPINB11    DKFZp686O07189    SERPINB1
    SERPINB7    SERPINB6    SERPINB8    SERPINB12    SERPINB9    SERPINB10
    SERPINB5    SERPINI2    SERPINB2    SERPINA3    SERPINA5    SERPINC1

    SERPINB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/326 SNPs in SERPINB3 are shown (see all 326)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739623261,2
    C,F--61322037(+) ATTCTG/CCCAGG 1 -- ds50013Minor allele frequency- C:0.22WA CSA 122
    rs49412101,2
    C,F,A,H--61322043(+) CCAGGC/TTGTTT 1 -- ds500126Minor allele frequency- T:0.46NS EA NA MN WA 2744
    rs116591651,2
    C,H--61322103(+) TATGGC/TAACCA 1 -- ds50010--------
    rs1836110871,2
    --61322202(+) ACAAAC/TAACCA 1 -- ds50010--------
    rs1885547151,2
    --61322276(+) CAAGGC/TTCCTC 1 -- ds50010--------
    rs1445857671,2
    --61322278(+) AGGCTC/TCTCCT 1 -- ds50010--------
    rs1484099801,2
    --61322346(+) CCTTTA/GTTTGT 1 -- ds50010--------
    rs739623301,2
    C,F--61322348(+) TTTGTT/ATGTGA 1 -- ds50013Minor allele frequency- A:0.22WA CSA 122
    rs1425020021,2
    --61322350(+) TGTTTA/GTGATT 1 -- ds50010--------
    rs6019001,2
    --61322372(-) AAAGAC/TAATTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SERPINB3 (61322431 - 61329197 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SERPINB3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717205CNV Deletion23290073
    nsv833672CNV Gain17160897


    Human Gene Mutation Database (HGMD): SERPINB3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600517    OMIM disorders: --

    20/40 diseases for SERPINB3 (see all 40):    About MalaCards
    cervical squamous cell carcinoma    squamous cell carcinoma    inverted papilloma    oral squamous cell carcinoma
    oral cancer    idiopathic pulmonary fibrosis    allergic asthma    esophageal squamous cell carcinoma
    cervical cancer    papilloma    cervicitis    pulmonary fibrosis
    leiomyosarcoma    laryngitis    esophageal cancer    psoriasis
    hepatocellular carcinoma    benign tumors    hepatitis b    transitional cell carcinoma

    2 diseases from the University of Copenhagen DISEASES database for SERPINB3:
    Urinary bladder cancer     Carcinoma

    SERPINB3 for disorders           About GeneDecksing

    10/25 Novoseek inferred disease relationships for SERPINB3 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 84 118 11182054 (5), 10653592 (2), 7687515 (2), 12743426 (2) (see all 74)
    cervical squamous cell carcinoma 65 4 18097581 (2), 9817979 (1), 10873412 (1)
    hepatocellular carcinoma 55.1 7 16550605 (1), 18638391 (1), 14993646 (1), 19956912 (1) (see all 6)
    squamous cell cancer 46.5 1 11241309 (1)
    cirrhosis 40.7 6 18657489 (1), 15887222 (1)
    tumors 35.9 32 2020345 (2), 1725572 (2), 12437110 (2), 17238969 (2) (see all 25)
    cancer 33.1 31 11369142 (3), 11241309 (2), 15286970 (2), 17364691 (1) (see all 18)
    cervical cancer 33.1 4 16641548 (3), 17291250 (1)
    psoriasis 31.8 3 18385761 (1), 16641548 (1), 20089382 (1)
    chronic liver disease 31.4 2 18638391 (1), 18657489 (1)

    Genetic Association Database (GAD): SERPINB3
    Human Genome Epidemiology (HuGE) Navigator: SERPINB3 (4 documents)

    Export disorders for SERPINB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINB3 gene, integrated from 9 sources (see all 148):
    (articles sorted by number of sources associating them with SERPINB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PubMed id 7724531)1, 2, 3, 9 Schneider S.S.... Silverman G.A. (1995)
    2. Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. (PubMed id 14970861)1, 2, 9 Pontisso P....Fassina G. (2004)
    3. Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease. (PubMed id 18657489)1, 4, 9 Turato C....Pontisso P. (2009)
    4. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. (PubMed id 10956412)1, 2, 9 Uemura Y.... Silverman G.A. (2000)
    5. Increased antiprotease activity of the SERPINB3 polym orphic variant SCCA-PD. (PubMed id 21383048)1, 2 Turato C....Pontisso P. (2011)
    6. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    7. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Binding of HBV to cells is mediated by SCCA1 but does not require the reactive site loop. (PubMed id 12975381)1, 2 Moore P.L.... Harrison T.J. (2003)
    10. Squamous cell carcinoma antigen is a new member of the serine protease inhibitors. (PubMed id 1958219)1, 2 Suminami Y.... Kato H. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6317 HGNC: 10569 AceView: SERPINB4andSERPINB3 Ensembl:ENSG00000057149 euGenes: HUgn6317
    ECgene: SERPINB3 Kegg: 6317 H-InvDB: SERPINB3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERPINB3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERPINB3 gene:
    Search GeneIP for patents involving SERPINB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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