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Aliases for SERPINB3 Gene

Aliases for SERPINB3 Gene

  • Serpin Family B Member 3 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 3 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 2 3
  • Squamous Cell Carcinoma Antigen 1 3 4
  • Protein T4-A 3 4
  • SCCA-1 3 4
  • SCCA1 3 4
  • Serpin B3 3
  • HsT1196 3
  • SCCA-PD 3
  • SSCA1 3
  • T4-A 3
  • SCCA 4
  • SCC 3

External Ids for SERPINB3 Gene

Previous HGNC Symbols for SERPINB3 Gene

  • SCC
  • SCCA1

Previous GeneCards Identifiers for SERPINB3 Gene

  • GC18M061161
  • GC18M061295
  • GC18M059455
  • GC18M059457
  • GC18M059473
  • GC18M058022
  • GC18M061322

Summaries for SERPINB3 Gene

GeneCards Summary for SERPINB3 Gene

SERPINB3 (Serpin Family B Member 3) is a Protein Coding gene. Diseases associated with SERPINB3 include Squamous Cell Carcinoma and Anus Cancer. Among its related pathways are Innate Immune System and Amoebiasis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB4.

UniProtKB/Swiss-Prot for SERPINB3 Gene

  • May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).

Gene Wiki entry for SERPINB3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB3 Gene

Genomics for SERPINB3 Gene

Regulatory Elements for SERPINB3 Gene

Enhancers for SERPINB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G063680 1.4 FANTOM5 Ensembl ENCODE 17.1 -20.7 -20691 3.4 TBP FOXA2 TAF1 JUN TEAD4 MAX BRCA1 YY1 NCOR1 HNF4G SERPINB3 SERPINB7 SERPINB12 SERPINB11 SERPINB5 GC18P063715 GC18P063716
GH18G063762 0.6 ENCODE dbSUPER 4.4 -100.8 -100814 1.5 MAFK SERPINB3 SERPINB7 SERPINB2
GH18G063708 0.5 ENCODE 0.2 -47.0 -47019 0.7 JUN FOS MAFK SERPINB11 GC18P063715 GC18P063716 SERPINB3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERPINB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERPINB3 Gene

Chromosome:
18
Start:
63,655,197 bp from pter
End:
63,661,963 bp from pter
Size:
6,767 bases
Orientation:
Minus strand

Genomic View for SERPINB3 Gene

Genes around SERPINB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB3 Gene

Proteins for SERPINB3 Gene

  • Protein details for SERPINB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29508-SPB3_HUMAN
    Recommended name:
    Serpin B3
    Protein Accession:
    P29508
    Secondary Accessions:
    • A6NDM2
    • B2RBT5
    • B3W5Y6
    • Q53H28
    • Q53YB5
    • Q86VF3
    • Q86W04
    • Q8IWL4
    • Q8IXI3
    • Q96J21
    • Q9BYF8

    Protein attributes for SERPINB3 Gene

    Size:
    390 amino acids
    Molecular mass:
    44565 Da
    Quaternary structure:
    • Interacts with MAPK8/JNK1.
    SequenceCaution:
    • Sequence=AAO11731.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SERPINB3 Gene

    Alternative splice isoforms for SERPINB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB3 Gene

Post-translational modifications for SERPINB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SERPINB3 (Serpin B3/SCCA1)

Protein Products

Assay Products

No data available for DME Specific Peptides for SERPINB3 Gene

Domains & Families for SERPINB3 Gene

Gene Families for SERPINB3 Gene

Protein Domains for SERPINB3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P29508

UniProtKB/Swiss-Prot:

SPB3_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB3: view

Function for SERPINB3 Gene

Molecular function for SERPINB3 Gene

UniProtKB/Swiss-Prot Function:
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).
UniProtKB/Swiss-Prot Induction:
Strongly up-regulated in the upper epidermis of sun-exposed skin.

Gene Ontology (GO) - Molecular Function for SERPINB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IDA 12975381
GO:0002020 protease binding IPI 21383048
GO:0004867 serine-type endopeptidase inhibitor activity NAS 7724531
GO:0004869 cysteine-type endopeptidase inhibitor activity IMP 21383048
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB3: view
genes like me logo Genes that share phenotypes with SERPINB3: view

Animal Model Products

CRISPR Products

miRNA for SERPINB3 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERPINB3 Gene

Localization for SERPINB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB3 Gene

Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB3 gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 5
cytosol 4
plasma membrane 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SERPINB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005634 nucleus IDA 20527027
GO:0005737 cytoplasm IDA,IEA 20527027
GO:0031410 cytoplasmic vesicle IDA 21383048
genes like me logo Genes that share ontologies with SERPINB3: view

Pathways & Interactions for SERPINB3 Gene

genes like me logo Genes that share pathways with SERPINB3: view

Pathways by source for SERPINB3 Gene

3 Reactome pathways for SERPINB3 Gene
1 KEGG pathway for SERPINB3 Gene

Gene Ontology (GO) - Biological Process for SERPINB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 20527027
GO:0010466 negative regulation of peptidase activity IEA,IDA 12949073
GO:0010718 positive regulation of epithelial to mesenchymal transition IMP 20527027
GO:0010950 positive regulation of endopeptidase activity IDA 20527027
GO:0010951 negative regulation of endopeptidase activity IMP 21383048
genes like me logo Genes that share ontologies with SERPINB3: view

No data available for SIGNOR curated interactions for SERPINB3 Gene

Drugs & Compounds for SERPINB3 Gene

(4) Drugs for SERPINB3 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-serine Experimental Pharma Agonist, Target 0
Phosphonoserine Experimental Pharma Target 0

(1) Additional Compounds for SERPINB3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB3: view

Transcripts for SERPINB3 Gene

mRNA/cDNA for SERPINB3 Gene

(1) REFSEQ mRNAs :
(23) Additional mRNA sequences :
(135) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINB3 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: -
SP2: - -
SP3: - - - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - -
SP6:
SP7:
SP8:
SP9: - - -

Relevant External Links for SERPINB3 Gene

GeneLoc Exon Structure for
SERPINB3
ECgene alternative splicing isoforms for
SERPINB3

Expression for SERPINB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB3 Gene

This gene is overexpressed in Vagina (x18.3), Esophagus - Mucosa (x17.9), and Cervix - Ectocervix (x12.4).

Protein differential expression in normal tissues from HIPED for SERPINB3 Gene

This gene is overexpressed in Stomach (19.2), Esophagus (11.6), Oral epithelium (8.5), and Urine (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINB3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SERPINB3 Gene:

SERPINB3

SOURCE GeneReport for Unigene cluster for SERPINB3 Gene:

Hs.227948

mRNA Expression by UniProt/SwissProt for SERPINB3 Gene:

P29508-SPB3_HUMAN
Tissue specificity: Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).

Evidence on tissue expression from TISSUES for SERPINB3 Gene

  • Lung(4.5)
  • Liver(4.2)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with SERPINB3: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB3 Gene

Orthologs for SERPINB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB3 34 35
  • 97.95 (n)
mouse
(Mus musculus)
Mammalia Serpinb3d 34 16 35
  • 71.5 (n)
Serpinb3a 35
  • 60 (a)
ManyToMany
Serpinb3b 35
  • 58 (a)
ManyToMany
Serpinb3c 35
  • 56 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 69 (a)
ManyToMany
SERPINB4 35
  • 67 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves OVALY 35
  • 45 (a)
ManyToMany
SERPINB14 35
  • 39 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Spn1 36
  • 36 (a)
Spn4 36
  • 36 (a)
serpin-27A 36
  • 34 (a)
CG9455 36
  • 33 (a)
CG9460 36
  • 33 (a)
Spn3 36
  • 33 (a)
Spn6 36
  • 33 (a)
Spn2 36
  • 32 (a)
Spn43Aa 36
  • 31 (a)
CG6717 36
  • 29 (a)
Spn5 36
  • 28 (a)
CG6687 36
  • 27 (a)
CG7722 36
  • 27 (a)
nec 36
  • 27 (a)
Spn43Ab 36
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea srp-7 36
  • 31 (a)
srp-1 36
  • 29 (a)
srp-6 36
  • 29 (a)
Species where no ortholog for SERPINB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINB3 Gene

ENSEMBL:
Gene Tree for SERPINB3 (if available)
TreeFam:
Gene Tree for SERPINB3 (if available)

Paralogs for SERPINB3 Gene

Variants for SERPINB3 Gene

Sequence variations from dbSNP and Humsavar for SERPINB3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000864610 -- 63,662,721(+) GGGGC(C/T)GGTCT upstream-variant-2KB
rs1000939413 -- 63,662,470(+) ATACT(A/G)TGGAG upstream-variant-2KB
rs1001149611 -- 63,658,240(+) GTGGA(C/G)ACAAG intron-variant
rs1001283829 -- 63,655,996(+) ACACG(G/T)GTCTC reference, synonymous-codon
rs1001518757 -- 63,658,433(+) CCCAT(G/T)GTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINB3 Gene

Variant ID Type Subtype PubMed ID
dgv621e214 CNV loss 21293372
esv2717205 CNV deletion 23290073
esv3642778 CNV loss 21293372
esv3642779 CNV gain 21293372
nsv1057179 CNV loss 25217958
nsv1066552 CNV gain 25217958
nsv833672 CNV gain 17160897

Variation tolerance for SERPINB3 Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.28; 70.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINB3 Gene

Human Gene Mutation Database (HGMD)
SERPINB3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB3 Gene

Disorders for SERPINB3 Gene

MalaCards: The human disease database

(12) MalaCards diseases for SERPINB3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
squamous cell carcinoma
  • epidermoid carcinoma
anus cancer
  • anal cancer
cervical squamous cell carcinoma
  • squamous cell carcinoma of cervix
anal carcinoma in situ
  • anal carcinoma stage 0
anal canal squamous cell carcinoma
  • squamous cell carcinoma of anal canal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SERPINB3

Genetic Association Database (GAD)
SERPINB3
Human Genome Epidemiology (HuGE) Navigator
SERPINB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINB3
genes like me logo Genes that share disorders with SERPINB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB3 Gene

Publications for SERPINB3 Gene

  1. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PMID: 7724531) Schneider S.S. … Silverman G.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 22 64
  2. Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease. (PMID: 18657489) Turato C. … Pontisso P. (Dig Liver Dis 2009) 3 22 46 64
  3. Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. (PMID: 14970861) Pontisso P. … Fassina G. (Br. J. Cancer 2004) 3 4 22 64
  4. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. (PMID: 10956412) Uemura Y. … Silverman G.A. (Int. J. Cancer 2000) 3 4 22 64
  5. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3 64

Products for SERPINB3 Gene

Sources for SERPINB3 Gene

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