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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINB3 Gene

protein-coding   GIFtS: 61
GCID: GC18M061295

serpin peptidase inhibitor, clade B (ovalbumin), member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbols: SCC, SCCA1)
 Explore 45 diseases affiliated with
SERPINB3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SERPINB3    

Aliases
for SERPINB3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 31 2     Protein T4-A2 3
SCCA11 2 3 5     Squamous Cell Carcinoma Antigen 12 3
HsT11961 2     SCCA-12 3
SCC1 2     SCCA-PD2
T4-A1 2     Serpin B32
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 31 2     SCCA3

External Ids:    HGNC: 105691   Entrez Gene: 63172   Ensembl: ENSG000000571497   OMIM: 6005175   UniProtKB: P295083   

Export aliases for SERPINB3 gene to outside databases

Previous GC identifers: GC18M061161 GC18M059455 GC18M059457 GC18M059473 GC18M058022


Summaries
for SERPINB3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508
Function: May act as a protease inhibitor to modulate the host immune response against tumor cells

Gene Wiki entry for SERPINB3


Genomic Views
for SERPINB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINB3 gene promoter:
         SRF   Pax-6   SRF (504 AA)   HNF-4alpha2   Ik-3   POU3F2   HNF-4alpha1   AREB6   HFH-1   Sox9   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SERPINB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.3

SERPINB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB3 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M061295:  view genomic region     (about GC identifiers)

Start:
 61,322,431 bp from pter      End:
 61,329,197 bp from pter
Size:
 6,767 bases      Orientation:
 minus strand

Proteins
for SERPINB3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508 (See protein sequence)
Recommended Name: Serpin B3  
Size: 390 amino acids; 44565 Da
Subcellular location: Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level
Developmental stage: Its expression is closely related to cellular differentiation in both normal and malignant
squamous cells
Sequence caution: Sequence=AAO11731.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SERPINB3:
2ZV6 (3D)    
Secondary accessions: A6NDM2 B2RBT5 B3W5Y6 Q53H28 Q53YB5 Q86VF3 Q86W04 Q8IWL4 Q8IXI3 Q96J21 Q9BYF8
Alternative splicing: 2 isoforms:  P29508-1   P29508-2   

Explore the universe of human proteins at neXtProt for SERPINB3: NX_P29508

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P29508

    • SERPINB3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008850.1  
    ENSEMBL proteins: 
     ENSP00000283752   ENSP00000329498  

    Human Recombinant Protein Products: 
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    Novus Biologicals SERPINB3 Proteins
    Novus Biologicals SERPINB3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SERPINB3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IBA--
    GO:0005737cytoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA--


    SERPINB3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SERPINB3

    Protein Domains /
    Families
    for SERPINB3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SERPINB3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P29508

    ProtoNet protein and cluster: P29508

    1 Blocks protein family: IPB000215 Serpin

    UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    Function
    for SERPINB3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508
    Function: May act as a protease inhibitor to modulate the host immune response against tumor cells

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618viral receptor activity IDA12975381
    GO:0004867serine-type endopeptidase inhibitor activity NAS7724531


    SERPINB3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SERPINB3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amoebiasis
    		Amoebiasis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for SERPINB3):
        Amoebiasis


    SERPINB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/12 Interacting proteins for SERPINB3 (P295082, 3 ENSP000002837524) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF1BP203332, 3MINT-49424 I2D: score=2 
    CTSKP432353, ENSP000002716514I2D: score=2 STRING: ENSP00000271651
    CTSL1P077113, ENSP000003453444I2D: score=2 STRING: ENSP00000345344
    CTSSP257743, ENSP000003579814I2D: score=2 STRING: ENSP00000357981
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615response to virus IDA12975381
    GO:0010466negative regulation of peptidase activity IDA12949073
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--
    GO:0043086negative regulation of catalytic activity IDA10956412


    SERPINB3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SERPINB3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINB3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINB3

    2 DrugBank Compounds for SERPINB3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    D-Serine-- 312-84-5target--10592235
    Phosphonoserine-- --target--10592235

    3 Novoseek chemical compound relationships for SERPINB3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scca1 99.3 245 20089382 (12), 12949073 (8), 10653592 (7), 14630915 (7) (see all 50)
    serine 66 27 10653592 (2), 9817977 (2), 9008232 (1), 20527027 (1) (see all 21)
    cysteine 54.4 20 10852705 (4), 10653592 (2), 9548757 (2), 14630915 (1) (see all 13)

    Search CenterWatch for drugs/clinical trials and news about SERPINB3 / SPB3 

    Transcripts
    for SERPINB3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SERPINB3 gene: 
    NM_006919.2  

    Unigene Cluster for SERPINB3:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 3
    Hs.227948  [show with all ESTs]
    Unigene Representative Sequence: NM_006919
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283752(uc002lji.3 uc010dqa.3 uc010dqb.3 uc010dqc.2)
    ENST00000332821

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: SERPINB3
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB3
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    Additional cDNA sequence: 

    AB046399.1 AF428135.1 AF428136.1 AF428137.1 AF428138.1 AF428139.1 AF461146.1 AJ515706.1 
    AK222746.1 AK222753.1 AK307261.1 AK308383.1 AK310948.1 AK314805.1 AY190327.1 AY245778.1 
    AY245781.1 BC005224.1 BC008483.1 BT006748.1 EU852041.1 S66896.1 U19556.1 

    4 DOTS entries:

    DT.453388  DT.100788918  DT.92432754  DT.97774794 

    24/135 AceView cDNA sequences (see all 135):

    BU687165 BU685771 AI081890 BC005224 U19557 BT006748 BC008483 AB046400 
    U19556 BM968451 BQ028405 BE156503 BM975848 AA398883 X89015 BU674965 
    AA861180 BU676264 BM968440 CB129418 BM978687 BX477537 BE720615 NM_006919 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB3 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
    SP1:                                                                                            -                                 
    SP2:                    -           -                                                                                             
    SP3:                    -           -     -     -     -     -     -     -     -     -     -     -     -     -                     
    SP4:                    -                                                                                                         
    SP5:                    -     -     -     -     -     -     -     -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for SERPINB3

    Expression
    for SERPINB3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SERPINB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINB3

    SOURCE GeneReport for Unigene cluster: Hs.227948

    UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508
    Tissue specificity: Squamous cells. Expressed in some hepatocellular carcinoma (at protein level)

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    In Situ
    Assay Products:     
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    Orthologs
    for SERPINB3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINB3 gene from 2/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 49(a)
    48(a)
    		 many ↔ many
    many ↔ many
    		 GL343311.1(570280-578337)
    GL343311.1(623565-636049)
    zebrafish
    (Danio rerio)    		 Actinopterygii serpinb1l16
    zgc:1737296
    (see all 5)    		 zgc:173729
    (see all 5)    		 50(a)
    45(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 16(54874440-54879870)
    16(54858268-54864487)


    ENSEMBL Gene Tree for SERPINB3 (if available)
    TreeFam Gene Tree for SERPINB3 (if available) 

    Paralogs
    for SERPINB3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINB3 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINE32  SERPINB132  
    SERPINB82  
    18/33 SIMAP similar genes for SERPINB3 using alignment to 1 protein entry:     SPB3_HUMAN(see all similar genes):
    SCCA2    SERPINB4    SERPINB13    SERPINB11    DKFZp686O07189    SERPINB1
    SERPINB7    SERPINB6    SERPINB8    SERPINB12    SERPINB9    SERPINB10
    SERPINB5    SERPINI2    SERPINB2    SERPINA3    SERPINA5    SERPINC1

    SERPINB3 for paralogs           About GeneDecksing



    Genomic Variants
    for SERPINB3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/254 NCBI SNPs in SERPINB3 are shown (see all 254)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs739623261,2
    		C,F,--61322037(+) ATTCTG/CCCAGG 1 -- ds50013Minor allele frequency- C:0.22WA CSA 122
    rs49412101,2
    		C,F,A,H,--61322043(+) CCAGGC/TTGTTT 1 -- ds500126Minor allele frequency- T:0.46NS EA NA MN WA 2744
    rs116591651,2
    		C,H--61322103(+) TATGGC/TAACCA 1 -- ds50010--------
    rs1836110871,2
    		--61322202(+) ACAAAC/TAACCA 1 -- ds50010--------
    rs1885547151,2
    		--61322276(+) CAAGGC/TTCCTC 1 -- ds50010--------
    rs1445857671,2
    		--61322278(+) AGGCTC/TCTCCT 1 -- ds50010--------
    rs1484099801,2
    		--61322346(+) CCTTTA/GTTTGT 1 -- ds50010--------
    rs739623301,2
    		C,F,,--61322348(+) TTTGTT/ATGTGA 1 -- ds50013Minor allele frequency- A:0.22WA CSA 122
    rs1425020021,2
    		--61322350(+) TGTTTA/GTGATT 1 -- ds50010--------
    rs6019001,2
    		--61322372(-) AAAGAC/TAATTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SERPINB3 (61322431 - 61329197 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SERPINB3
         1 CNV: 5059
    Human Gene Mutation Database (HGMD): SERPINB3

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    Disorders / Diseases
    for SERPINB3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SERPINB3 for disorders           About GeneDecksing

    OMIM gene information: 600517    OMIM disorders: --

    20/45 diseases for SERPINB3 (see all 45):    About MalaCards
    squamous cell carcinoma    carcinoma    ovarian sex cord tumors    cervical squamous cell carcinoma
    inverted papilloma    idiopathic pulmonary fibrosis    urinary bladder cancer    oral squamous cell carcinoma
    esophageal squamous cell carcinoma    pulmonary fibrosis    atopic dermatitis    transitional cell carcinoma
    allergic asthma    cervicitis    laryngeal cancer    papilloma
    laryngitis    hepatitis b    oral cancer    liver disease

    2 diseases from the University of Copenhagen DISEASES database for SERPINB3:
    Urinary bladder cancer     Carcinoma

    10/25 Novoseek disease relationships for SERPINB3 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 84 118 11182054 (5), 10653592 (2), 7687515 (2), 12743426 (2) (see all 74)
    cervical squamous cell carcinoma 65 4 18097581 (2), 9817979 (1), 10873412 (1)
    hepatocellular carcinoma 55.1 7 16550605 (1), 18638391 (1), 14993646 (1), 19956912 (1) (see all 6)
    squamous cell cancer 46.5 1 11241309 (1)
    cirrhosis 40.7 6 18657489 (1), 15887222 (1)
    tumors 35.9 32 2020345 (2), 1725572 (2), 12437110 (2), 17238969 (2) (see all 25)
    cancer 33.1 31 11369142 (3), 11241309 (2), 15286970 (2), 17364691 (1) (see all 18)
    cervical cancer 33.1 4 16641548 (3), 17291250 (1)
    psoriasis 31.8 3 18385761 (1), 16641548 (1), 20089382 (1)
    chronic liver disease 31.4 2 18638391 (1), 18657489 (1)

    Human Genome Epidemiology (HuGE) Navigator: SERPINB3 (4 documents)

    Export disorders for SERPINB3 gene to outside databases

    Publications
    for SERPINB3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINB3 gene, integrated from 9 sources (see all 144):
    (articles sorted by number of sources associating them with SERPINB3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PubMed id 7724531)1, 2, 3, 9 Schneider S.S.... Silverman G.A. (1995)
    2. Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. (PubMed id 14970861)1, 2, 9 Pontisso P....Fassina G. (2004)
    3. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. (PubMed id 10956412)1, 2, 9 Uemura Y.... Silverman G.A. (2000)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Binding of HBV to cells is mediated by SCCA1 but does not require the reactive site loop. (PubMed id 12975381)1, 2 Moore P.L.... Harrison T.J. (2003)
    6. Squamous cell carcinoma antigen is a new member of the serine protease inhibitors. (PubMed id 1958219)1, 2 Suminami Y.... Kato H. (1991)
    7. Up-regulation of serpin SCCA1 is associated with epid ermal barrier disruption. (PubMed id 20089382)1, 9 Katagiri C....Hibino T. (2010)
    8. Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus. (PubMed id 14993646)1, 9 Ruvoletto M.G....Pontisso P. (2004)
    9. Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. (PubMed id 10653592)1, 9 Cataltepe S....Upton M.P. (2000)
    10. Expression pattern of squamous cell carcinoma antigen in oesophageal dysplasia and squamous cell carcinoma. (PubMed id 17523076)1, 9 Parenti A....De Caro R. (2007)

    External Searches for SERPINB3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing SERPINB3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6317 HGNC: 10569 AceView: SERPINB4andSERPINB3 Ensembl:ENSG00000057149 euGenes: HUgn6317
    ECgene: SERPINB3 Kegg: 6317 H-InvDB: SERPINB3

    Other Databases showing SERPINB3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SERPINB3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERPINB3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SERPINB3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SERPINB3 gene:
    Search GeneIP for patents involving SERPINB3

    GeneCards and IP:
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